Molecules, Vol. 24, Pages 2368: Optimization of Ultrasonic-Assisted Extraction of Total Phenolics from Citrus aurantium L. Blossoms and Evaluation of Free Radical Scavenging, Anti-HMG-CoA Reductase Activities
The objective of this study was to develop an ultrasonic-assisted procedure for the extraction of total phenolics from Citrus aurantium L. blossoms (CAB) and evaluate the free radical scavenging activity and anti-HMG-CoA reductase activity of the total phenolics. In this work, a Box– Behnken design based on single-factor experiments was used to explore the optimum extraction process. Under the optimum conditions (extraction solvent 70.31% ethanol, extraction temperature 61.94 °C, extraction time 51.73 min, and liquid-to-solid ratio 35.63 mL/g), the extraction yield of total phenolics ...
Source: Molecules - June 26, 2019 Category: Chemistry Authors: Hao Hu Hou Cao Wang Guan Zhang Wang Yu Guo Tags: Article Source Type: research

Use of the PEPTEST ™ tool for the diagnosis of GERD in the Emergency Department
Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal disorders in the general population, with a prevalence of 8.8% –25.9% in Europe [1]. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - June 25, 2019 Category: Emergency Medicine Authors: Angela Saviano, Carmine Petruzziello, Mattia Brigida, Ilaria Tersigni, Alessio Migneco, Andrea Piccioni, Luisa Saviano, Marcello Covino, Francesco Franceschi, Veronica Ojetti Source Type: research

[Emerging Issues in Esophageal Motility Diseases].
Abstract With the advances in technology and medical knowledge, new diseases are being identified and investigated. Esophageal motility disorders have been re-defined using high-resolution manometry and their pathogenesis are being better understood. The use of opioid analgesics is increasing worldwide, particularly in the United States, but their chronic use can cause opioid-induced esophageal dysfunction, which mimics spastic motor disorders, including achalasia type 3 or 2 and esophagogastric junction outflow obstruction. Eosinophilic esophagitis is identified by eosinophilic infiltration confirmed on a patholo...
Source: Korean J Gastroenter... - June 25, 2019 Category: Gastroenterology Authors: Kim GH, Jung KW Tags: Korean J Gastroenterol Source Type: research

A Reminder From the Past: Unsuspected Splenic Calcified Granulomatosis Decades After Pulmonary Tuberculosis
A healthy 51-year-old man was referred for chest computed tomography (CT) after complaining of chronic cough without history of smoking, atopy, drug treatment, or gastroesophageal reflux. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - June 24, 2019 Category: General Medicine Authors: Ami Schattner, Yair Glick, Inna Kapelyan Tags: Clinical Communication to the Editor Source Type: research

Characterization of Esophageal Motility in Infants With Congenital Diaphragmatic Hernia Using High-resolution Manometry
Conclusions: Normal esophageal wave patterns are present in the investigated patients with iCDH. EGJ end-expiratory pressure seems lower in patients with iCDH without patch suggesting a decreased EGJ barrier function hence increased vulnerability to gastroesophageal reflux. Patch repair appears to increase end-expiratory pressure at the EGJ above that of controls suggesting that patch surgery tightens the EGJ, thereby increasing flow resistance. This is in line with the increased Pressure Flow Index. In infants with a patch, the inspiration-expiration pressure difference is lower, reflecting diminished activity of the cr...
Source: Journal of Pediatric Gastroenterology and Nutrition - June 23, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Effect of Gastric Acid Suppressants on Response to a Physical Activity Intervention and Major Mobility Disability in Older Adults: Results from the Lifestyle Interventions for Elders (LIFE) Study
ConclusionsCompared to non ‐users, participants using either PPIs or H2RAs had increased risk of MMD, pMMD, and injurious falls. It is not known if these effects are related to the individual pharmacology of each medication, reduced acid secretion, or the underlying disease state. Further study is required to determine caus ality.This article is protected by copyright. All rights reserved. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - June 23, 2019 Category: Drugs & Pharmacology Authors: Patrick J Squires, Marco Pahor, Todd M Manini, Joshua D Brown Tags: Original Research Article Source Type: research

Robot-assisted Toupet fundoplication and associated cholecystectomy in symptomatic giant hiatal hernia with situs viscerum inversus—A case report and literature review
ConclusionIn challenging cases as the giant hernias ad rare anomaly as situs viscerum inversus, the surgical treatment can be facilitated by the use of robotic technology. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - June 22, 2019 Category: Surgery Source Type: research

Mean platelet volume and red cell distribution width as potential new biomarkers in children with gastroesophageal reflux disease.
Authors: Sevencan NO, Cesur O, Cakar M, Dogan E, Ozkan AE, Benli AR Abstract The aim of this study was to calculate the corrected rate of reflux in children with gastroesophageal reflux (GER)-like complaints by 24-hour pH monitoring and esophagogastroduodenoscopy (EGD), and to determine the utility of mean platelet volume (MPV) and red cell distribution width (RDW) as diagnostic biomarkers of GER disease (GERD) in children. The subjects in this prospective study were 109 children, 6 to 18 years old. Of them, 74 subjects were with GER symptoms and 35 healthy controls. The subjects were divided into three groups: tho...
Source: American Journal of Translational Research - June 22, 2019 Category: Research Tags: Am J Transl Res Source Type: research

The combination of wheat peptides and fucoidan protects against chronic superficial gastritis and alters gut microbiota: a double-blinded, placebo-controlled study
AbstractPurposeChronic gastritis is observed in almost half world population. Traditional medications against chronic gastritis might produce adverse effects, so alternative nutritional strategies are needed to prevent the aggravation of gastric mucosal damage. The aim of this study is to evaluate the protective effect of the combination of wheat peptides and fucoidan (WPF) on adults diagnosed with chronic superficial gastritis in a randomized, double-blind, placebo-controlled clinical trial.MethodsParticipants were randomized to receive WPF (N  =  53) or placebo (N  =  53) once daily for 45&nbs...
Source: European Journal of Nutrition - June 22, 2019 Category: Nutrition Source Type: research

Clinical and pathophysiological outcomes of the robotic-assisted Heller –Dor myotomy for achalasia: a single-center experience
AbstractLaparoscopic Heller myotomy and Dor fundoplication is considered a safe and effective treatment for achalasia. Robotic-assisted Heller –Dor procedure (RAHD) has emerged as an alternative approach due to improved visualization and fine motor control. The aim of this prospective study was to evaluate clinical, and functional results of RAHD. We evaluated a group of 66 patients with achalasia that underwent robotic-assisted Heller– Dor operation. Before treatment all patients underwent a diagnostic work-up such as upper endoscopy, esophageal barium swallow and high resolution manometry. The presence of pos...
Source: Journal of Robotic Surgery - June 22, 2019 Category: Surgery Source Type: research

Hypopharyngeal Diverticulum: Toward a Unified Understanding of Its Etiopathogenesis
We report using laser endoscopy to divide the inter-diverticular septum followed by transmucosal cricopharyngeus myotomy. Presentation of a rare, bilobed diverticulum emphasizes the importance of the midline prevertebral raphe in anchoring the pharyngeal constrictor muscl es with respect to the CPM. This lends support to the hypothesis that the etiopathogenesis of ZD is multifactorial while guiding us to a unified understanding of ZD. (Source: Dysphagia)
Source: Dysphagia - June 22, 2019 Category: Speech-Language Pathology Source Type: research

Diagnostic performance of the endoscopic pressure study integrated system (EPSIS): a novel diagnostic tool for gastroesophageal reflux disease
Endoscopy DOI: 10.1055/a-0938-2777 Background The endoscopic pressure study integrated system (EPSIS) is a prototypic system for monitoring intragastric pressure (IGP) fluctuations that result from opening of the cardia during gastric distension. The performance of EPSIS for the diagnosis of gastroesophageal reflux disease (GERD) was evaluated. Methods A retrospective analysis was conducted of data prospectively collected over a 2-year period from 59 patients who underwent gastroscopy, EPSIS, and 24-hour pH monitoring. Using a dedicated electronic device and a through-the-scope catheter, maximum IGP (IGPmax...
Source: Endoscopy - June 19, 2019 Category: Gastroenterology Authors: Inoue, Haruhiro Shimamura, Yuto de Santiago, Enrique Rodriguez Kobayashi, Yasutoshi Ominami, Masaki Fujiyoshi, Yusuke Sumi, Kazuya Ikeda, Haruo Onimaru, Manabu Manolakis, Anastassios C Tags: Innovations and brief communications Source Type: research

The impact of cervical lymph node dissection on acid and duodenogastroesophageal reflux after intrathoracic esophagogastrostomy following transthoracic esophagectomy
ConclusionCervical lymph node dissection increases acid reflux and DGER and can lead to an increase in the incidence of reflux esophagitis in patients undergoing intrathoracic esophagogastrostomy. (Source: Surgery Today)
Source: Surgery Today - June 19, 2019 Category: Surgery Source Type: research

Long-term (15-year) objective evaluation of 150 patients after laparoscopic Nissen fundoplication
Laparoscopic Nissen fundoplication is the preferred operative treatment for patients with gastroesophageal reflux disease. The most recent published results only refer to clinical evaluations and few discuss objective measurements. Our purpose was to determine the late results of laparoscopic Nissen fundoplication, performing clinical, endoscopic, histologic, and functional studies. (Source: Surgery)
Source: Surgery - June 19, 2019 Category: Surgery Authors: Attila Csendes, Omar Orellana, Nicole Cuneo, Gustavo Mart ínez, Manuel Figueroa Source Type: research

[Uncontrolled occupational asthma: Talking about comorbidities].
CONCLUSIONS: As with all cases of severe asthma, the assessment of comorbidities must be systematic in the presence of an occupational asthma which persists after the cessation of the occupational exposure. The management of these comorbidities can lead to an improvement in asthma control and severity. PMID: 31204233 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - June 18, 2019 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Development of visual scoring system with Tc-99m DMSA renal scintigraphy to predict the risk of recurrence of symptomatic urinary tract infections in pediatric patients
AbstractObjectiveVesicoureteral reflux (VUR) is a major risk factor for recurrent symptomatic urinary tract infection (UTI) in pediatric patients. In addition, dimercaptosuccinic acid renal scintigraphy (DMSA) is an important diagnostic modality of VUR. However, the value of DMSA for predicting recurrent pediatric UTI has not been studied. Therefore, we aimed to develop visual scoring system (VSS) with DMSA to predict the risk of recurrence of symptomatic urinary tract infection in pediatric patient under the age of 24  months.MethodsPediatric UTI patients who visited our tertiary hospital emergency department and und...
Source: Annals of Nuclear Medicine - June 18, 2019 Category: Nuclear Medicine Source Type: research

Standard protocol devised by the Japanese Pediatric Impedance Working Group for combined multichannel intraluminal impedance-pH measurements in children
AbstractMultichannel intraluminal impedance-pH measurements (MII-pH) are useful for evaluating acid and non-acid gastroesophageal reflux (GER). However, the use of MIH-pH is not yet established in Japan. The Japanese Pediatric Impedance Working Group (Japanese-PIG) convened to devise a standard protocol for MII-pH in Japanese children. The expert members of the Japanese-PIG collected data on pediatric MII-pH from the relevant literature in English, including the standard protocol of MII-pH presented by the European PIG, and the insights of international experts. The resultant consensus was included in the contents of the s...
Source: Surgery Today - June 18, 2019 Category: Surgery Source Type: research

Swallowing MRI for GERD —diagnosis and treatment monitoring
ConclusionReal-time MRI swallowing, as a  noninvasive and nonionizing method, offers a new perspective for the combined anatomic and functional visualization of GERD, with the possibility of direct visualization of the surrounding structures. (Source: European Surgery)
Source: European Surgery - June 17, 2019 Category: Surgery Source Type: research

Demographics and Clinical and Endoscopic Characteristics of Patients with Helicobacter pylori Infection and Gastroesophageal Reflux Disease: A Case-Control Study.
This study was aimed at assessing the role of H. pylori infection in GERD utilizing a large cohort of patients diagnosed with GERD. Methods and Materials: All patients who underwent gastroscopy for an indication of GERD during the study period between 2015 and 2017 at the EMMS Nazareth Hospital were considered eligible for the study and therefore were included. H. pylori infection was determined by the rapid urease test or histology. Severity of esophagitis was assessed using the Los Angeles classification. Univariate analysis was performed to figure out differences between patients according to H. pylori infection sta...
Source: Gastroenterology Research and Practice - June 16, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Clinical and immunological features in a cohort of patients with partial DiGeorge syndrome followed at a single center
DiGeorge syndrome (DGS) is a primary immunodeficiency characterized by various degrees of T-cell deficiency. In partial DGS (pDGS), other risk factors could predispose to recurrent infections, autoimmunity, and allergy. The aim of this study was to assess the effect of different factors in the development of infections, autoimmunity, and/or allergy in patients with pDGS. We studied 467 pDGS patients in follow-up at Great Ormond Street Hospital. Using a multivariate approach, we observed that palatal anomalies represent a risk factor for the development of recurrent otitis media with effusion. Gastroesophageal reflux/dyspha...
Source: Blood - June 13, 2019 Category: Hematology Authors: Giardino, G., Radwan, N., Koletsi, P., Morrogh, D. M., Adams, S., Ip, W., Worth, A., Jones, A., Meyer-Parsonson, I., Gaspar, H. B., Gilmour, K., Davies, E. G., Ladomenou, F. Tags: Pediatric Hematology, Immunobiology and Immunotherapy Source Type: research

Impact of a 6-Month Micronutrient-Dense Plant-Rich Nutrition Intervention on Health and Well-Being at the Worksite.
Authors: Sutliffe JT, Gardner JC, Gorman MM, Carnot MJ, Wetzel WS, Fortin T, Sutliffe CA, Adams A Abstract This nonrandomized pilot study utilized the health belief model and the theory of planned behavior to assess the effectiveness of perceived behavioral control to determine the impact of a micronutrient-dense plant-rich (mNDPR) dietary intervention on employee health and wellness at the worksite. Seventy-one employees and/or spouses (≥18 years) who met the inclusion criteria were recruited from a regional medical center and a local university. Participants were provided more than 14 hours of in...
Source: Journal of Nutrition and Metabolism - June 12, 2019 Category: Nutrition Tags: J Nutr Metab Source Type: research

Overlapping of irritable bowel syndrome with erosive esophagitis and the performance of Rome criteria in diagnosing IBS in a clinical setting.
Authors: El-Salhy M, Gilja OH, Hatlebakk JG Abstract Irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD) overlap. It is not clear whether GERD is caused by non‑erosive esophagitis, or erosive esophagitis. The Rome criteria are not widely used for the diagnosis of IBS in the clinic. In total, 1,489 IBS patients without red flags were included in the present retrospective study. They comprised of 1,331 females and 158 males with a mean age of 51 years. The diagnosis of IBS was verified by endoscopic and histopathological examinations. Whereas erosive esophagitis occurred in 97% of patient...
Source: Molecular Medicine Reports - June 12, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

The Effect of Trimebutine and/or Helicobacter pylori Eradication on the Gastroesophageal Reflux Disease, Irritable Bowel Syndrome, and Functional Dyspepsia Overlapping Disorders.
Authors: Kountouras J, Gavalas E, Doulberis M, Polyzos SA, Papaefthimiou A, Touloumtsi M, Vardaka E, Kountouras K, Papanikolopoulou K, Katsinelos P PMID: 31177649 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - June 12, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Gastroesophageal Reflux Events Occurring During a Meal Can Still Be Temporally Associated With a Symptom Even When Analysis Settings Are Set to Exclude Meals.
Authors: Woodley FW PMID: 31177648 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - June 12, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Vonoprazan versus Lansoprazole for the Initial Treatment of Reflux Esophagitis: A Cost-effectiveness Analysis in Japan.
Conclusion The P-CAB strategy was consistently superior to the conventional PPI strategy using the original LPZ in terms of cost-effectiveness and the number of days for which medication was required. Thus, VPZ appears to be the drug of choice for the acute medical treatment of reflux esophagitis. PMID: 31178490 [PubMed - as supplied by publisher] (Source: Internal Medicine)
Source: Internal Medicine - June 12, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research

Comment On: Gastro-esophageal reflux related physiological changes following sleeve gastrectomy and Roux-en-Y gastric bypass: A prospective comparative study
I would like to congratulate the authors on a very well written and well-designed study.i I believe the question that is being asked and subsequently answered in this paper is of paramount importance. Over the last several years there has been a paucity of data that is contradictory in the area of reflux after sleeve gastrectomy. However, in the most recent literature it would appear that the incidence of gastroesophageal reflux (GERD) is significant. A recent meta-analysis just released and ahead of print in the Annals of Surgery by Yeung et al, identified 46 studies with 10,000 plus patients and found an increase in post...
Source: Surgery for Obesity and Related Diseases - June 12, 2019 Category: Surgery Authors: Richard M. Peterson Source Type: research

Comment On: gastroesophageal reflux related physiologic changes after sleeve gastrectomy and Roux-en-Y gastric bypass: a prospective comparative study
I would like to congratulate the authors on a very well-written and well-designed study [1]. I believe the question that is being asked and subsequently answered in this paper is of paramount importance. Over the last several years, there has been a paucity of data that are contradictory in the area of reflux after sleeve gastrectomy. However, in the most recent literature it would appear that the incidence of gastroesophageal reflux (GERD) is significant. A recent meta-analysis in the Annals of Surgery by Yeung et  al. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - June 12, 2019 Category: Surgery Authors: Richard M. Peterson Tags: Editorial comment Source Type: research

Comment On: gastroesophageal reflux related physiologic changes after sleeve gastrectomy and Roux-en-Y gastric bypass: a prospective comparative study.
PMID: 31288971 [PubMed - as supplied by publisher] (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - June 12, 2019 Category: Surgery Authors: Peterson RM Tags: Surg Obes Relat Dis Source Type: research

Comment on: Gastroesophageal reflux –related physiologic changes after sleeve gastrectomy and Roux-en-Y gastric bypass: a prospective comparative study
I would like to congratulate the authors on a very well-written and well-designed study [1]. I believe the question that is being asked and subsequently answered in this paper is of paramount importance. Over the last several years, there has been a paucity of data that are contradictory in the area of reflux after sleeve gastrectomy. However, in the most recent literature it would appear that the incidence of gastroesophageal reflux (GERD) is significant. A recent meta-analysis in the Annals of Surgery by Yeung et  al. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - June 12, 2019 Category: Surgery Authors: Richard M. Peterson Tags: Editorial comment Source Type: research

The potential role of potassium-competitive acid blockers in the treatment of gastroesophageal reflux disease
Purpose of review Gastroesophageal reflux disease (GERD) is primarily a motor disorder, but its pathogenesis is multifactorial. Although gastric acid secretion is usually normal in GERD patients, treatment with proton pump inhibitors (PPIs) has become the standard of care, despite increasing awareness of their shortcomings. In this article, a new class of antisecretory drugs (namely potassium-competitive acid blockers, P-CABs), developed to overcome these limitations, is discussed. Recent findings P-CABs block the K+ exchange channel of the proton pump, resulting in rapid, competitive, reversible inhibition of acid se...
Source: Current Opinion in Gastroenterology - June 11, 2019 Category: Gastroenterology Tags: ESOPHAGUS: Edited by Stuart J. Spechler Source Type: research

Management of achalasia in 2019
Purpose of review The purpose of this review is to discuss the efficacy, morbidity and side-effects of innovative management strategies for achalasia that include high-resolution manometry (HRM), pneumatic dilatation, laparoscopic Heller's myotomy (LHM), injection of botulinum toxin into the lower esophageal sphincter and peroral endoscopic myotomy (POEM). Recent findings HRM has enabled identification of achalasia subtypes that have important prognostic implications. Pneumatic dilatation is a commonly-used and cost-effective method of treating achalasia but has shown poor longevity of symptom relief compared with oth...
Source: Current Opinion in Gastroenterology - June 11, 2019 Category: Gastroenterology Tags: ESOPHAGUS: Edited by Stuart J. Spechler Source Type: research

How to choose among fundoplication, magnetic sphincter augmentation or transoral incisionless fundoplication
Purpose of review To examine current trends and research in nonmedical approaches to the treatment of gastroesophageal reflux disease (GERD). Recent findings Long-term studies of GERD patients treated with transoral incisionless fundoplication (TIF) have found that a large portion of patients resume proton pump inhibitor therapy. In patients with uncomplicated GERD, magnetic sphincter augmentation (MSA) shows excellent short-term results in both patient satisfaction and physiologic measures of GERD, with fewer postoperative side-effects than fundoplication, although dysphagia can be problematic. Summary Fundoplicat...
Source: Current Opinion in Gastroenterology - June 11, 2019 Category: Gastroenterology Tags: ESOPHAGUS: Edited by Stuart J. Spechler Source Type: research

Esophagitis in patients without gastroesophageal reflux disease or eosinophilic esophagitis: diagnostic considerations
Purpose of review A multitude of inflammatory diseases other than gastroesophageal reflux disease (GERD) and eosinophilic esophagitis can affect the esophagus. Despite the deceptively simple organization of squamous mucosa and its limited number of inflammatory responses, a wide array of histologic patterns can be seen in inflammatory disorders involving the esophagus. Each such histologic pattern is associated with a limited number of underlying conditions, and the clinician can use this information to narrow the differential diagnosis. The purpose of this review is to review and discuss the pathologic diagnosis of esop...
Source: Current Opinion in Gastroenterology - June 11, 2019 Category: Gastroenterology Tags: ESOPHAGUS: Edited by Stuart J. Spechler Source Type: research

Multicenter collaborative retrospective evaluation of peroral endoscopic myotomy for esophageal achalasia: analysis of data from more than 1300 patients at eight facilities in Japan
ConclusionOur results confirmed the safety and efficacy of POEM in a large patient series and support POEM as the first-line and standard treatment for esophageal achalasia. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - June 10, 2019 Category: Surgery Source Type: research

On the Allylic Oxidation of Ent-kaurenic Acid Methyl Ester with Lead Tetra-acetate.
Authors: Rojas J, Aparicio R, Usubillaga A Abstract In this paper, results obtained upon treatment of the methyl ester of ent-kaur-16-en-19-oic acid (1b) with lead tetra-acetate under reflux in glacial acetic acid solution and an argon atmosphere are described. After 30 minutes reflux, GC-MS analysis of the product indicated the presence of three substances, the initial compound (1b, 7 %), the methyl ester of ent-kaur-16-en-15-O-acetyl-19-oic acid (2a, C₂₃H₃₀0₄, 45 %), and its isomer, the methyl ester of ent-kaur-15-en-17- 0-acetyl-19-oic acid (3a, 47 %). Flash chromatography over silica gel containing 20...
Source: Natural Product Communications - June 9, 2019 Category: Biochemistry Tags: Nat Prod Commun Source Type: research

Enhanced oral delivery and anti-gastroesophageal reflux activity of curcumin by binary mixed micelles.
Authors: Sun Y, Li Y, Shen Y, Wang J, Tang J, Zhao Z Abstract The aim of this study was to improve the solubility, oral bioavailability, and anti-gastroesophageal reflux activity of curcumin by preparing two curcumin-loaded, novel, binary mixed micelles (CM-M). The two CM-M were prepared by ethanol thin-film hydration method. One (CM-T) was prepared using D-alpha-tocopheryl polyethylene glycol 1000 succinate and Solutol®HS15, and the other (CM-F) was prepared using Pluronic®F127 and Solutol®HS15. The entrapment efficiency and drug loading of CM-T were 83.61 ± 0.54% and 2.20 &...
Source: Drug Development and Industrial Pharmacy - June 8, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research

Characteristics of Chinese chronic cough patients
Publication date: Available online 6 June 2019Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Li Long, Kefang LaiAbstractChronic cough is one of the most common complains for patients seeking medical attention in both general practice and respiratory specialist clinics. Cough variant asthma, eosinophilic bronchitis, upper airway cough syndrome, as well as gastro-esophageal reflux disease are common conditions associated with chronic cough, and cough variant asthma, eosinophilic bronchitis account for a higher proportion of patients with chronic cough in China than in Western countries. An older female predomina...
Source: Pulmonary Pharmacology and Therapeutics - June 7, 2019 Category: Respiratory Medicine Source Type: research

Interneurons: Learning on the Job
Publication date: 5 June 2019Source: Neuron, Volume 102, Issue 5Author(s): Renata Batista-Brito, Gord FishellIn this issue, Wester et al. (2019) examine the obligate relationship between cortical interneurons and pyramidal neurons. By genetically converting superficial IT pyramidal cells into PT-like deep-layer pyramidal cells, they alter the position, connectivity, and gene expression within CGE-derived interneurons. (Source: Neuron)
Source: Neuron - June 7, 2019 Category: Neuroscience Source Type: research

Biliary tumorigenic effect on hypopharyngeal cells is significantly enhanced by pH reduction
In this study, repetitive applications of conjugated primary bile acids with unconjugated secondary bile acid, deoxycholic acid (DCA), on human hypopharyngeal primary cells reveal that strongly acidic pH (4.0) optimally enhances the tumorigenic effect of bile, by inducing activation of NF‐κB, STAT3 nuclear translocation, bcl‐2 overexpression and significant overexpression of the oncogenic mRNA phenotype, compared to weakly acidic pH (5.5) or neutral pH (7.0). As the pH b ecomes less acidic the partially activated primary bile acids and activated DCA begin to exert their influence; however, with significantly less...
Source: Cancer Medicine - June 7, 2019 Category: Cancer & Oncology Authors: Sotirios G. Doukas, Bruno Cardoso, Jacob I. Tower, Dimitra P. Vageli, Clarence T. Sasaki Tags: ORIGINAL RESEARCH Source Type: research

What is causing the rising incidence of esophageal adenocarcinoma in the West and will it also happen in the East?
AbstractIn the West, the incidence of esophageal adenocarcinoma, which is a long-term complication of damage by gastroesophageal reflux, has been rising over recent decades. Two main factors are likely to account for this increase. The first is the rising incidence of central obesity which promotes gastroesophageal reflux. The second is the falling incidence ofH. pylori infection and associated atrophic gastritis which reduces the acidity and peptic activity of gastric juice, the main factors damaging to the esophageal mucosa. The rise in esophageal adenocarcinoma has been mirrored by a fall in gastric cancer consistent wi...
Source: Journal of Gastroenterology - June 6, 2019 Category: Gastroenterology Source Type: research

Increased number of regulatory T cells in esophageal tissue of patients with eosinophilic esophagitis in comparison to gastro esophageal reflux disease and control groups.
In this study, we enumerated and compared T lymphocytes and Tregs in esophageal tissue of patients with EoE, gastroesophageal reflux disease (GERD) and normal controls. METHODS: Ten patients with EoE, ten patients with GERD and eight normal controls were included. Immunohistochemistry staining was used to enumerate T lymphocytes and Tregs. CD3+ cells were considered as T cells and FOXP3+, CD3+ cells were considered as Tregs. T cells and Tregs were counted in 10 high power fields (HPF) (×400) for each patient and the average of 10 HPFs was recorded. RESULTS: The mean±SEM of Tregs in esophageal tissue ...
Source: Allergologia et Immunopathologia - June 6, 2019 Category: Allergy & Immunology Authors: Mousavinasab F, Babaie D, Nilipour Y, Mansouri M, Imanzadeh F, Dara N, Rohani P, Khatami K, Sayyari A, Khoddami M, Kazemiaghdam M, Mesdaghi M Tags: Allergol Immunopathol (Madr) Source Type: research

A prospective study of gastro-oesophageal reflux disease symptoms and quality of life 1-year post-laparoscopic sleeve gastrectomy
Conclusion: GORD symptoms improve for most patients' 1-year post-operatively. A small proportion of patients will develop troublesome GORD, but overall satisfaction remains high. (Source: Journal of Minimal Access Surgery)
Source: Journal of Minimal Access Surgery - June 4, 2019 Category: Surgery Authors: Andrew G.N. Robertson Andrew J Cameron Brian Joyce Phil Le Page Bruce Tulloh Andrew C de Beaux Peter J Lamb Source Type: research

Scleroderma and other connective tissue disorders
Gastrointestinal symptoms are common in both inflammatory and non-inflammatory connective tissue disorders and can involve any part of the gastrointestinal tract from the mouth to the anus. Dysphagia, gastrooesophageal reflux, nausea, vomiting, abdominal pain and change in bowel habit are common symptoms and usually arise from gastrointestinal dysmotility and altered visceral sensitivity. In scleroderma, sensorimotor dysfunction is pronounced and can result in complications such as Barrett's oesophagus, gastroparesis, small intestinal bacterial overgrowth, malabsorption and malnutrition, with an associated reduction in sur...
Source: Medicine - June 3, 2019 Category: Internal Medicine Authors: Asma Fikree Tags: New advances Source Type: research

Techno-economic modeling and optimization of catalytic reactive distillation for the esterification reactions in bio-oil upgradation
Publication date: Available online 31 May 2019Source: Chemical Engineering Research and DesignAuthor(s): M. Arif Khan, Yusuf G. AdewuyiAbstractEquilibrium reactive distillation (RD) process simulation and economic evaluation were carried out for the esterification of complex mixtures of several fatty acids and water (representative of crude bio-oils) with n-butanol using Aspen PLUS process simulator and economic analyzer. Complete design and optimization were carried out using evolutionary techniques from simplest system to the most rigorous one with introduction of intermittent progressive complexity. Prior to distillatio...
Source: Chemical Engineering Research and Design - June 2, 2019 Category: Chemistry Source Type: research

Changing Trends of Color of Different Laryngeal Regions in Laryngopharyngeal Reflux Disease.
CONCLUSION: Hue values of separate laryngeal regions are different. In negative group, the hue values of interarytenoid region are similar with positive group, and the sensitivity to the acid are different from different regions. The sensitivity in the true vocal folds may be present. PMID: 31155940 [PubMed - as supplied by publisher] (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - June 2, 2019 Category: ENT & OMF Authors: Du C, Thayer P, Yan Y, Liu Q, Wang L, Jiang J Tags: Ear Nose Throat J Source Type: research

Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease.
This study was conducted on a health cohort consisting of 10,158 participants who underwent comprehensive health screening. Lifestyles and gastrointestinal symptoms were investigated using a self-reported structured questionnaire. Questionnaires about menstrual status were added for the women. RESULTS: The prevalence of RE in men was significantly higher than that in women (10.6% vs. 2.0%, P
Source: Journal of Korean Medical Science - June 1, 2019 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Omentopexy in Sleeve Gastrectomy Reduces Early Gastroesophageal Reflux Symptoms
Introduction: Laparoscopic sleeve gastrectomy (LSG) is one of the surgical procedures indicated in the treatment of obesity. The occurrence of gastroesophageal reflux (GER) in the postoperative period of this surgery is related to a reduction in the lower esophageal sphincter (LES) tone and the presence of gastric residual fundus (RF) associated with increased gastric intraluminal pressure. Fixation of the remaining gastric reservoir to the gastrosplenic and gastrocolic ligaments (omentopexy) has emerged as a technical option to avoid or decrease GER in the postoperative period of LSG. Objective: To evaluate the prese...
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - June 1, 2019 Category: Surgery Tags: Original Articles Source Type: research

Post-operative giant hiatal hernia: A single center experience
To verify the results of the treatment of post-operative giant hiatal hernia (POGH). The POGH becomes each time more frequent after surgical treatment of the gastroesophageal reflux. Fifteen patients (6 females and 9 males; 43.66 ± 5.05 years old; BMI 22.13 ± 1.92) were referred to our Service, for surgical treatment of a type III POGH 30.4 ± 1.76 months after treatment of gastroesophageal reflux disease. The need for a reoperation was determined mainly by dysphagia. Reoperation was completed laparoscopically in all patients and the mean postoperative hospital stay was 3.2 ± 1...
Source: Medicine - June 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Association of serum gastric inhibitory polypeptide and pancreatic polypeptide levels with prolonged esophageal acid exposure time in refractory gastroesophageal reflux disease
Conclusion: The serum levels of GIP and PP in refractory GERD patients with prolongation of AET are significantly elevated, mainly in the upright position. (Source: Medicine)
Source: Medicine - June 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research