Clinical outcomes of gastroesophageal reflux disease-related chronic cough following antireflux fundoplication
ConclusionsAntireflux surgery, although less predictable, is effective for the treatment of gastroesophageal reflux disease-related chronic cough. (Source: Esophagus)
Source: Esophagus - October 15, 2019 Category: Gastroenterology Source Type: research

Proton Pump Inhibitors and Radiofrequency Ablation for Treatment of Barrett's Esophagus.
Abstract Gastroesophageal reflux disease (GERD) is characterized by acid and bile reflux in the distal oesophagus, and this may cause the development of reflux esophagitis and Barrett's oesophagus (BE). The natural histological course of untreated BE is non-dysplastic or benign BE (ND) than low-grade (LGD), and high-grade dysplastic (HGD) BE, with the expected increase in malignancy transfer to oesophagal adenocarcinoma (EAC). The gold standard for BE diagnostics involves high-resolution white-light endoscopy, followed by uniform endoscopy findings description (Prague classification) with biopsy performance accord...
Source: Mini Reviews in Medicinal Chemistry - October 15, 2019 Category: Chemistry Authors: Dugalic P, Djuranovic S, Pavlovic-Markovic A, Dugalic V, Tomasevic R, Gluvic Z, Obradovic M, Bajic V, Isenovic ER Tags: Mini Rev Med Chem Source Type: research

Statins and gastroesophageal reflux disease: A meta-analysis
Conclusions: The current meta-analysis found that the risk of GERD was numerically lower among statin users although the pooled result did not reach statistical significance. Therefore, more studies are still needed to further clarify this potential benefit of statins. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - October 14, 2019 Category: Internal Medicine Authors: K Wijarnpreecha P Panjawatanan L Leelasinjaroen P Ungprasert Source Type: research

Post-reflux swallow-induced peristaltic wave index and mean nocturnal baseline impedance predict PPI response in GERD patients with extra esophageal symptoms
Mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index are able to increase the diagnostic yield of impedance-pH and are associated to proton pump inhibitor (PPI) response. Few data concerning these variables in patients with extra-esophageal symptoms (EES) are available. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - October 14, 2019 Category: Gastroenterology Authors: Mentore Ribolsi, Michele Pier Luca Guarino, Alessandro Tullio, Michele Cicala Tags: Alimentary Tract Source Type: research

Associations between the severity of reflux esophagitis in children and changes in oxidative stress, serum inflammation, vasoactive intestinal peptide and motilin.
Authors: Deng Y, Pan L, Qian W Abstract Changes in the levels of serum oxidative stress indexes, gastrointestinal hormones and inflammatory factors in children with different severity of reflux esophagitis (RE) were detected. Sixty child patients diagnosed with gastroesophageal reflux disease (GERD) via gastroscopy were selected and divided into non-erosive reflux disease group (NERD group, n=12) and RE group (n=48) according to whether there was esophageal mucosal injury. In RE group, the patients were further divided into grade I RE group (n=15), grade II RE group (n=18) and grade III RE group (n=15) based on the...
Source: Experimental and Therapeutic Medicine - October 12, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Peroral endoscopic myotomy for esophageal motility disorders
ConclusionsPOEM can be a new option for the treatment of esophageal movement disorders, but large sample, multi-center, long-term study reports are needed, and it promotes the development of NOTES technology. (Source: Esophagus)
Source: Esophagus - October 12, 2019 Category: Gastroenterology Source Type: research

Personal, academic and stress correlates of gastroesophageal Reflux Disease among college students in southwestern Saudi Arabia: A cross-section study
ConclusionGERD is a prevalent problem among college students in southwestern Saudi Arabia as it affects about one third of the students. Considering high prevalence of GERD, associated daily life impacts, young age of the studied subject and the risk of future complications, this condition could represent a challenging health and economic problem. The risk of GERD is higher among; males, smokers, former smokers, non-health care colleges students and subjects exposed to high perceived stress. (Source: Annals of Medicine and Surgery)
Source: Annals of Medicine and Surgery - October 11, 2019 Category: General Medicine Source Type: research

Phase 4 Study in Patients From Asia With Gastroesophageal Reflux Disease Treated With Dexlansoprazole.
Conclusions: In Asian patients with GERD, treatment with dexlansoprazole modified-release indicates a favorable efficacy and safety profile in relieving heartburn and acid regurgitation symptoms. PMID: 31597230 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 11, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

4D spatiotemporal evolution of liquid spray using kilohertz-rate x-ray computed tomography
Four-dimensional (x,y,z,t) x-ray computed tomography was demonstrated in an optically complex spray using an imaging system consisting of ... (Source: Optics Letters)
Source: Optics Letters - October 10, 2019 Category: Physics Authors: B. R. Halls N. Rahman M. N. Slipchenko J. W. James A. McMaster M. D. A. Ligthfoot J. R. Gord T. R. Meyer Source Type: research

Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
We read with interest the recent article by Perotin et al. [1], which investigated epithelial dysregulation in obese severe asthma patients with gastro-oesophageal reflux. The researchers found that bronchial epithelial gene expression, sampled by airway brushing, identified an endotype defined by epithelial dysregulation associated with obesity, gastro-oesophageal reflux and use of proton pump inhibitors (OGP cluster). Relative to non-asthmatic healthy controls, pathway signature analysis indicated that the wingless tail (WNT)/β-catenin pathway was the top epithelial pathway dysregulated in the OGP cluster. The clust...
Source: European Respiratory Journal - October 10, 2019 Category: Respiratory Medicine Authors: Ward, C., Kharaba, Z. J. Tags: Original Articles: Correspondence Source Type: research

Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
We thank C. Ward and Z.J. Kharaba for their interesting comments on the OGP endotype of severe asthma that we recently described [1]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 10, 2019 Category: Respiratory Medicine Authors: Perotin, J.-M., Djukanovic, R., Davies, D. E. Tags: Original Articles: Correspondence Source Type: research

Risk factors predisposing to cardia gastric adenocarcinoma: Insights and new perspectives
The etiology of adenocarcinoma of the cardia and the gastroesophageal junction (GEJ) is not known and is doubted. It is thought that cardia gastric adenocarcinoma (CGA) is distinct from adenocarcinomas located in the esophagus or distal stomach, both epidemiologically and biologically. Moreover, CGA is often identified in the advanced stage having a poor prognosis. In this paper, we would like to ascertain the possible role of GC family history, lifestyle, demographics, gastroesophageal reflux disease,Helicobacter pylori infection, and multiple genetic and epigenetic risk factors as well as several predisposing conditions ...
Source: Cancer Medicine - October 10, 2019 Category: Cancer & Oncology Authors: Esmat Abdi, Saeid Latifi ‐Navid, Saber Zahri, Abbas Yazdanbod, Farhad Pourfarzi Tags: REVIEW Source Type: research

Chronic Obstructive Pulmonary Disease and the Risk of Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Primary Care Case-Control Study
Background: Chronic gastroesophageal reflux predisposes to the development of esophageal adenocarcinoma (EAC). Asthma and medication to treat it are associated with gastroesophageal reflux and EAC. We studied subjects with chronic obstructive pulmonary disease (COPD) to examine the relationship between COPD and medication used to treat it, and the risk of reflux esophagitis, Barrett’s esophagus, and EAC. Methods: A case-control study from the UK General Practice Research Database was conducted. Cases were aged 50 or above with a diagnosis of COPD and were matched with controls without a diagnosis of COPD by age,...
Source: Journal of Clinical Gastroenterology - October 9, 2019 Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research

Association of Vitamin D and Parathyroid Hormone With Barrett’s Esophagus
Conclusions: Contrary to our hypothesis, we found an inverse association between serum PTH and Barrett’s esophagus. Validation of the finding and the mechanism of that association deserves further study. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - October 9, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

[The value of DMSA scintigraphy in the diagnostic evaluation of vesicoureteric reflux].
Abstract In terms of treatment planning, the radiologic phenomenon of vesicoureteric reflux has become less important than its inherent risk of further urinary tract infections and loss of renal function. Whilst radiologic and sonographic voiding cystourethrography continues to be the gold standard in the mere detection of vesicoureteric reflux, dimercaptosuccinic acid scanning is important for risk stratification. Also it serves to confirm renal involvement in uncertain situations with urinary tract infection and fever. In older children, it is the standard in primary diagnostics. Furthermore, it enables the diag...
Source: Aktuelle Urologie - October 9, 2019 Category: Urology & Nephrology Authors: Haid B Tags: Aktuelle Urol Source Type: research

Role of Esophageal Mean Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Discriminating Chinese Patients With Heartburn.
Authors: Sun YM, Gao Y, Gao F Abstract Background/Aims: Recently, esophageal mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index have been proposed, which can increase the diagnostic role of multichannel intraluminal impedance and pH recording (MII/pH) for differentiating patients with heartburn. Therefore, our aim is to investigate the role of esophageal proximal MNBI, distal MNBI, and PSPW index in differentiating Chinese patients with heartburn. Methods: Patients with heartburn from the Beijing Anzhen Hospital, who underwent upper gastrointestinal endoscopy ...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives.
Authors: Lin S, Li H, Fang X Abstract Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophageal sphincter, frequent transient lower esophageal sphincter relaxation, esophageal hypersensitivity, reduced resistance of the esophageal mucosa against the refluxed contents, ineffective esophageal motility, abnormal bolus transport, deficits initiating secondary p...
Source: Journal of Neurogastroenterology and Motility - October 8, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Mechanism Underlying the Formation of a Cluster of Metabolic Syndrome.
CONCLUSIONS: The paper demonstrates that the autonomic dysfunction of nervous system (on a par with insulin resistance) is the main link in the development of MetS. This provides the basis for including the mentioned states - cardiac autonomic neuropathy, lower urinary tract symptoms and gastroesophageal reflux disease - into the MetS cluster. PMID: 31589129 [PubMed - as supplied by publisher] (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 8, 2019 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

Concurrent Magnetic Sphincter Augmentation and Hiatal Hernia Repair for Refractory GERD Following Laparoscopic Sleeve Gastrectomy
Gastroesophageal reflux disease (GERD) has a reported incidence of between 10 to 20% in western populations with an even higher incidence in populations with obesity (1). The vast majority of patients are managed medically with surgical intervention undertaken in those with recalcitrant GERD. Populations with obesity and recalcitrant GERD who are interested in weight loss surgery have historically undergone Laparoscopic Roux En Y Gastric Bypass (LRYGB). De Goot et al in their 2009 meta-analysis demonstrated improvement in GERD in people with obesity following LRYGB(2). (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 8, 2019 Category: Surgery Authors: Gordian U. Ndubizu, Anthony T. Petrick, Ryan Horsley Source Type: research

Concurrent magnetic sphincter augmentation and hiatal hernia repair for refractory GERD after laparoscopic sleeve gastrectomy
Gastroesophageal reflux disease (GERD) has a reported incidence of between 10% and 20% in Western populations with an even higher incidence in populations with obesity [1]. The vast majority of patients are managed medically with surgical intervention undertaken in those with recalcitrant GERD. Populations with obesity and recalcitrant GERD who are interested in weight loss surgery have historically undergone laparoscopic Roux-en-Y gastric bypass (LRYGB). De Goot et  al. [2], in their 2009 meta-analysis, demonstrated improvement in GERD in people with obesity after LRYGB. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 8, 2019 Category: Surgery Authors: Gordian U. Ndubizu, Anthony T. Petrick, Ryan Horsley Tags: Video case report Source Type: research

Therapeutic Options for Early Cancer of the Esophagogastric Junction
Publication date: Available online 6 October 2019Source: Cirugía Española (English Edition)Author(s): Félix Junquera, Sonia Fernández-Ananín, Carmen BalaguéAbstractEarly-stage (T1) esophagogastric junction cancer continues to represent 2%–3% of all cases. Adenocarcinoma is the most frequent and important type, the main risk factors for which are gastroesophageal reflux and Barrett's esophagus with dysplasia.Patients with mucosal (T1a) or submucosal (T1b) involvement initially require a thorough digestive endoscopy, and narrow-band imaging can improve visualization. Endoscopic...
Source: Cirugia Espanola - October 7, 2019 Category: Surgery Source Type: research

Prevalence and characterization of chronic rhinosinusitis in patients with non ‒cystic fibrosis bronchiectasis at a tertiary care center in the United States
BackgroundChronic rhinosinusitis (CRS) is associated with bronchiectasis; however, this relationship has not been well studied in the United States (US) population. In this work we aimed to determine the prevalence of CRS among patients with bronchiectasis affiliated with a US tertiary medical center and identify which comorbid diseases are associated with the presence of CRS in patients with bronchiectasis.MethodsThis was a retrospective cohort study in which data were obtained from a large database warehouse at a tertiary care center. Patients with bronchiectasis were identified from 2007 to 2017 using diagnosis codes fr...
Source: International Forum of Allergy and Rhinology - October 7, 2019 Category: Allergy & Immunology Authors: Shaan N. Somani, Jason H. Kwah, Chen Yeh, David B. Conley, Leslie C. Grammer, Robert C. Kern, Michelle Prickett, Robert P. Schleimer, Stephanie S. Smith, Whitney W. Stevens, Bruce K. Tan, Kevin C. Welch, Anju T. Peters Tags: ORIGINAL ARTICLE Source Type: research

Botox Injection into the Lower Esophageal Sphincter Induces Hiatal Paralysis and Gastroesophageal Reflux.
CONCLUSION: ISIB, in addition to decreasing LES pressure, paralyzes the esophageal hiatus (crural diaphragm) and induces GER. PMID: 31589467 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 7, 2019 Category: Physiology Authors: Kumar D, Zifan A, Mittal RK Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Esophagitis After Bariatric Surgery: Large Cross-sectional Assessment of an Endoscopic Database
ConclusionEE is more prevalent after SG compared with RYGB in a pre-bariatric surgery cohort with GERD. SG is associated with significant esophageal physiologic changes conducive to GERD and its clinical consequences. (Source: Obesity Surgery)
Source: Obesity Surgery - October 4, 2019 Category: Surgery Source Type: research

Clinical, Endoscopic, and Histologic Findings at the Distal Esophagus and Stomach Before and Late (10.5  Years) After Laparoscopic Sleeve Gastrectomy: Results of a Prospective Study with 93% Follow-Up
ConclusionsPatients submitted to LSG showed a significant and progressive increase in the presence of “de novo” GERD. Also, an increased duodenogastric reflux was seen through an open and immobile pylorus. Therefore, based on these results, it seems like LSG is a “pro-reflux” surgical procedure, which should be continuously evaluated late after surgery. (Source: Obesity Surgery)
Source: Obesity Surgery - October 3, 2019 Category: Surgery Source Type: research

Isorhamnetin alleviates esophageal mucosal injury in a chronic model of reflux esophagitis.
In conclusion, isorhamnetin attenuated esophageal mucosal injury in rats with chronic RE, possibly by suppressing formation of cytokines and infiltration of inflammatory cells, inhibiting p38 and NFκB pathways, and enhancing HO-1 activity. PMID: 31586635 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - October 3, 2019 Category: Drugs & Pharmacology Authors: Liu G, Jiang C, Li D, Yao L, Lin Y, Guo B, Qiu J, Wang W, Wang W Tags: Eur J Pharmacol Source Type: research

Barrett's esophagus: "All diseases are divine and all are human".
In conclusion, BE may have two different presentations: environmental ("human", reflux) or sporadic BE, which is the most common form, and genetic ("divine", inherited) or familiar BE, less common but with a greater risk for malignancy. As they might be two different diseases, surveillance programs and treatments should also be different. PMID: 31566411 [PubMed - as supplied by publisher] (Source: Revista Espanola de Enfermedades Digestivas)
Source: Revista Espanola de Enfermedades Digestivas - October 2, 2019 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

CSACI position statement: Newer generation H1-antihistamines are safer than first-generation H1-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria
Oral H1-antihistamines (AHs) are the most commonly used therapy to treat allergic rhinitis and chronic urticaria. Older, first-generation AHs (e.g. diphenhydramine, hydroxyzine) have significant and common side e... (Source: Allergy, Asthma and Clinical Immunology)
Source: Allergy, Asthma and Clinical Immunology - October 1, 2019 Category: Allergy & Immunology Authors: Michael N. Fein, David A. Fischer, Andrew W. O ’Keefe and Gord L. Sussman Tags: Review Source Type: research

Effects of Laparoscopic Sleeve Gastrectomy on Quality of Life Related to Gastroesophageal Reflux Disease
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - October 1, 2019 Category: Surgery Authors: Andrea Balla Silvia Quaresima Livia Palmieri Ardit Seitaj Annamaria Pronio Danilo Badiali Abe Fingerhut Pietro Ursi Alessandro M. Paganini Source Type: research

Effects of Laparoscopic Sleeve Gastrectomy on Quality of Life Related to Gastroesophageal Reflux Disease
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic and Advanced Surgical Techniques)
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - October 1, 2019 Category: Surgery Authors: Andrea Balla Silvia Quaresima Livia Palmieri Ardit Seitaj Annamaria Pronio Danilo Badiali Abe Fingerhut Pietro Ursi Alessandro M. Paganini Source Type: research

Thickened Feedings for Infants with Gastroesophageal Reflux.
PMID: 31573169 [PubMed - in process] (Source: American Family Physician)
Source: American Family Physician - October 1, 2019 Category: Primary Care Authors: Finck A, Morris L Tags: Am Fam Physician Source Type: research

A666 Laparoscopic Nissen Fundoplication with Roux en Y Gastric bypass is a proper surgery for Morbid Obesity & intractable GERD (Video presentation)
Persistent Gastro-esophageal reflux symptoms for more than 4ys in spite of different medical treatment with persistent endoscopic signs of reflux esophagitis and gastritis especially in patient with BMI> 35 kg/m2 need special concern when seek for surgical management of obesity. Laparoscopic Roux-en-Y gastric bypass has been reported to be the most effective and less debatable option for effective treatment of morbid obesity with persistent GERD (Gastro-esophageal reflux disease). It may be associated with antireflux surgery or not. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Ayman Soliman Source Type: research

A641 Less is More: Avoiding Conversion to RYGB with LINX placement after Sleeve Gastrectomy
Laparoscopic sleeve gastrectomy (LSG) is a commonly performed bariatric procedure in obesity management. Gastroesophageal reflux disease (GERD) in this population has reported rates of 23-100% GERD after LSG . GERD after LSG has been noted with recent studies demonstrating de novo reflux or symptom exacerbation despite weight loss. Fundoplication is not an option, and medically refractory GERD after LSG is usually treated with conversion to Roux-en-Y gastric bypass (RYGB). This video demonstrates the placement of a magnetic sphincter augmentation device after LSG as an alternative to conversion to RYGB. (Source: Surgery fo...
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Arielle Lee, Ryan Broderick, Joslin Cheverie, Bryan Sandler, Garth Jacobsen, Santiago Horgan Source Type: research

A637 Magnetic Sphincter Augmentation for Treatment of Gastroesophageal Reflux Disease after Roux-En-Y Gastric Bypass
We present a video of a 42-year old female who underwent laparoscopic MSA placement for the treatment of GERD after prior Roux-en-Y gastric bypass (RYGB) for morbid obesity. The patient had an initial body mass index of 35.8 kg/m2 and underwent a RYGB in 2006. She developed dumping syndrome treated with sclerotherapy of the gastro-jejunal anastomosis in 2009. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Catherine Tsai, Joerg Zehetner Source Type: research

A627 Converting Old Procedures. Conversion of a Failed Vertical-Banded Gastroplaty to a Vertical Sleeve Gastrectomy
54 years old female from Calgary Alberta Canada who had a Vertical Banded Gastroplasty (VBG) in 2002 in Canada; in 2011 she requested me a revision from VBG to a gastric band due to weight regain with modest results and ultimately regaining all her weight back and developing gastro-esophageal reflux, GERD) she came back for a second revision in 2018 requesting a laparoscopic sleeve gastrectomy (LSG). Her initial BMI was 42 with two major co-morbidities diabetes mellitus (DMII) and high blood pressure (HBP)that went under remission with the primary surgery ; but due to de novo GERD and weight regain due to a band revision s...
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Jaime Ramos-Kelly Source Type: research

A603 Long-term use of acid suppression therapy does not differ between gastric bypass and sleeve gastrectomy patients
Gastroesophageal reflux disease (GERD) is common in patients with obesity and different bariatric procedures have different effects on the symptoms. There is little long-term data regarding acid suppression therapy (AST: proton pump inhibitor or H2-blocker) use after bariatric surgery. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Xiaoxi Feng, Stacy Brethauer, Ali Aminian, Toms Augustin Source Type: research

A590 Initial Experience of a Single Institution Utilizing Anatomy-Based Sleeve Gastrectomy: A MBSAQIP Database Analysis
We present our institution ’s initial experience using this technique. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: HINALI ZAVERI, Aaron Hoffman, Jonathan Thompson, Arianne Train, Dennis Hanseman, Amit Surve Source Type: research

A571 Oesophageal adenocarcinoma after conversion of sleeve gastrectomy to Roux-Y gastric bypass for gastroesophageal reflux. A case report.
Incidence of gastroesophageal reflux (GER) after sleeve gastrectomy (SG) is a concern considering the popularity of this procedure, lack of long-term data and theoretical risk of esophageal cancer development. Gastric bypass is considered the best therapeutic option for persisting reflux after SG. However up to 30% of patients suffer from post-operative GER. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Michele Podetta, Anne-Sophie Studer, Theodoros Thomopoulos, Ronald Denis, Henri Atlas, Pierre Garneau, Radu Pescarus Source Type: research

A560 Laparoscopic magnetic sphincter augmentation system for the treatment of severe GERD post Sleeve Gastrectomy
We present the first series of cases with severe GERD post Sleeve, that underwent this surgery. To verify the efficacy of the MSA for the treatment of pathological GERD in patients with previous sleeve gastrectomy, with no weight regain. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Marcos Berry, Lionel Urrutia, Rodrigo Lynch Source Type: research

A555 Endoscopic plication of gastrojejunostomy and gastric pouch after gastric bypass for severe gastroesophageal reflux disease
We present our experience with endoscopic plication of the gastrojejunostomy and gastric pouch as a treatment for postoperative GERD in bypass patients. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Kellen Hayes, George Eid Source Type: research

A535 Hiatal Hernia Repair and Conversion to Omega Loop Bypass after Sleeve Gastrectomy
Sleeve Gastrectomy alters the normal stomach anatomy resulting in a significant incidence of hiatal hernia and gastroesophageal reflux disease. Although many patients remain asymptomatic, many complain of severe reflux symptoms not responsive to medical management. To describe the diagnosis and treatment of hiatus hernia after sleeve gastrectomy with conversion to Omega Loop Bypass and using fixation suture technique. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Enas Alawi Source Type: research

A510 Impact of Preoperative BMI, Hiatal Hernia Repair and Long-term %Excess Weight Loss Impact on GERD Symptoms after Sleeve Gastrectomy
Sleeve gastrectomy (SG) patients often present with gastroesophageal reflux (GERD) symptoms postoperatively. Our aim was to evaluate factors that impact GERD recidivism or de novo after SG. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Bhavani Pokala, Priscila Armijo, Laura Flores, Dmitry Oleyniov, Vishal Kothari Source Type: research

A470 Reflux disease after Sleevegastrectomy – a quality of life assessment
Morbidly obese patients are affected by gastroesophageal reflux disease (GERD) more frequently than lean patients. Because of conflicting results, the indication to sleeve gastrectomy (SG) in patients with GERD is still debated. Aim of the study was to evaluate the de novo incidence of GERD and the resulting quality of life in patients undergoing sleeve gastrectomy. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Anna Dupree, Stefan Wolter, Oliver Mann Source Type: research

A463 Anatomy-based sleeve gastrectomy superior to sleeve gastrectomy with bougie in a retrospective cohort analysis
Sleeve gastrectomy pouch imperfections have been implicated in postoperative gastroesophageal reflux disease (GERD) and other complications. Anatomy-based sleeve gastrectomy (ABS) has been developed to improve the shape, volume and anatomic consistency of the laparoscopic sleeve gastrectomy (LSG) pouch. In ABS, a pouch is created by applying a clamp 1-cm from the gastroesophageal junction, 3-cm from the incisura, 6-cm from the pylorus and stapling adjacent to the clamp. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Amit Surve, Jonathan Thompson, Dennis Hanseman, Aaron Hoffman, Arianne Train, HINALI ZAVERI Source Type: research

A370 Revisional surgery in 2000 consecutive Patients Who Had Sleeve Gastrectomy for Morbid Obesity in a Single Center.
Laparoscopic sleeve gastrectomy (SG) is the most commonly performed bariatric procedure in France. Despite its safety and efficacy, long-term complications of SG are not rare including gastro-esophageal reflux disease (GERD), twisting, stenosis, insufficient weight loss, and weight regain. The goal of this study was to analyze the pattern and short-term results of surgical revision in patients with SG. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Elie Chouillard Source Type: research

A331 Standard Laparoscopic Sleeve Gastrectomy vs Laparoscopic Sleeve Gastro-Omento-Pexy Technique and GERD: A Retrospective Case Control Study
Laparoscopic sleeve gastrectomy (LSG) affords patients excellent long term excess weight loss; however, one of the primary problems reported with this procedure is new onset or worsening gastro-esophageal reflux (GERD). Studies show the rate of de novo reflux after LSG to be 47.8%. Long-term GERD portends poor quality of life and increases the risk of esophageal cancer. We propose modifying the LSG by reattaching the omentum to the “new” greater portion of the sleeve stomach reduces the incidence of GERD by restoring natural anatomy. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Caitlin Polistena, Caroline Dong, Candice Chipman, Jack Liu, Erin Moran-Atkin, Jenny Choi Source Type: research

A242 sadi-s to rygb for severe reflux and esophagitis
Sleeve gastrectomy is clearly related to gastroesophageal reflux and esophagitis. This complication may apply also for malabsorptive procedures that include sleeve gastrectomy as SADIS. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Amador Garcia Ruiz de Gordejuela, Ramon Vilallonga Puy, Renato Roriz da Silva, Enric Caubet Busquet, Oscar Gonz ález López, Miquel Kraft Carre, Ruth Blanco-Colino, Rocío Martín Sánchez, Carlos Petrola, Jose Fort López-Barajas Source Type: research

A237 Laparoscopic conversion to Roux en Y Gastric Bypass and Ligamentum Teres Cardiopexy for Gastroesophageal and Bile Reflux after Sleeve Gastrectomy
Subtle aberrations in the post-sleeve stomach may result in severe gastroesophageal and bile reflux. Cardiopexy of the stomach with the ligamentum teres, initially described in 1964 by Pedinielli, has been used to reinforce the lower esophageal sphincter and hinders mediastinal retraction of the stomach. However, diversion of duodenal contents is required for definitive treatment of bile reflux. The presented video depicts a case of 37 year-old female presenting with frequent regurgitation and reflux refractory to medical therapy 5 years after laparoscopic sleeve gastrectomy. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Aaron Sabbota, Amy Yetasook, Pearl Ma, Keith Boone, Kelvin Higa, Amarita Klar Source Type: research

A177 Better or Worse? A State-wide Analysis of Patient Reported Reflux Symptoms Before and After Bariatric Surgery
Gastroesophageal reflux can improve or worsen after bariatric surgery depending on procedure type. Our goal was to compare patient reported symptoms of reflux after gastric bypass (GB) and sleeve gastrectomy (SG) based on preoperative symptom severity. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Oliver Varban, Jyothi Thumma, Dana Telem, Nabeel Obeid, Jonathan Finks, Amir Ghaferi, Justin Dimick Source Type: research

A165 long term results after laparoscopic sleeve gastrectomy with concomitant posterior cruroplasty: five-year follow-up update
Hiatal hernia (HH) repair during laparoscopic sleeve gastrectomy (LSG) has been advocated to reduce postoperative gastroesophageal reflux disease (GERD) and/or intrathoracic migration (ITM) incidence. Previous,mid-term Results of a prospective, comparative study evaluating posterior cruroplasty concomitant with LSG (group A 48 patients with simple vs. group B 48 reinforced with bioabsorbable mesh) confirmed the safety and effectiveness of simultaneous procedures. Present aim: to report the 60 months follow-up update, evaluating GERD, esophageal lesions ’ incidence and HH’s recurrence. (Source: Surgery for Obesi...
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Gianfranco Silecchia, Cristian Eugeniu Boru Source Type: research