Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease.
Authors: Khoury T, Mari A, Amara H, Jabaren M, Watad A, Nseir W, Sbeit W, Mahamid M Abstract Background and Aims: We aimed to assess whether chronic statins used (> 6 months) were protective of the development of esophagitis in patients with gastroesophageal reflux disease. In the presence of esophagitis, complications such as strictures, Barrett's esophagus, and adenocarcinoma were the most common. Statins, lipid lowering drugs with a pleiotropic effect, are recently implicated in various pathologies. Nevertheless, the possible impact of statins in esophagitis development has never been assessed. Methods: W...
Source: Canadian Journal of Gastroenterology - March 13, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

The effectiveness of mindfulness meditation in relief of symptoms of depression and quality of life in patients with gastroesophageal reflux disease
In this study, we looked at the effectiveness of mindfulness-based stress reduction (MBSR) in relieving the symptoms of depression and the health-related quality of life of these patients.MethodsA longitudinal, interventional open-label study was carried out on 60 patients with GERD and 60 controls. Zung Self-Rating Depression Scale (ZSDS) was used for assessing depression before and after the intervention. The GERD-Health-Related Quality of Life (GERD-HRQL) questionnaire was used to assess the health-related quality of life and the Freiburg Mindfulness Inventory (FMI) to quantify the amount of mindfulness over the study p...
Source: Indian Journal of Gastroenterology - March 13, 2019 Category: Gastroenterology Source Type: research

Synthesis of Novel Bis-pyrazole Derivatives as Antimicrobial Agents.
CONCLUSION: The good results of the antimicrobial examination of the new synthesized bis-pyrazoles is the considerable evidence of the importance of bis-heterocyclic compounds which encourage us to continue to design and synthesis a novel series with potent biological activity in the future. PMID: 30864524 [PubMed - as supplied by publisher] (Source: Molecular Medicine)
Source: Molecular Medicine - March 12, 2019 Category: Molecular Biology Authors: Muhammad ZA, Alshehrei F, Zayed MEM, Farghaly TA, Abdallah MA Tags: Mini Rev Med Chem Source Type: research

Correction to: Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study
In the original publication of this article, Tables 2, 3, 4, 5 and 6 were published incorrectly. The correct tables are given below. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 11, 2019 Category: Gastroenterology Source Type: research

Role of Late DMSA Renal Scan in Detecting High-Grade Vesicoureteral Reflux
ConclusionsIn older children, the normal late DMSA scan predicted the absence of high-grade VUR, obviating the need for a VCUG. This approach could be a possible strategy for children not studied at acute infection time. (Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - March 11, 2019 Category: Pediatrics Source Type: research

Can Impedance-pH Testing on Medications Reliably Identify Patients with GERD as Defined by Pathologic Esophageal Acid Exposure off Medications?
ConclusionMII-pH testingon medications in patients with refractory GERD symptoms does not reliably correlate with a diagnosis of GERD as defined by pathologic esophageal acid exposure off medications. The commonly used abnormal MII-pH test value of ≥ 48 total reflux episodes is not validated and should not be used. However, in our series, patients with>  73 total reflux episodes had a high likelihood of having pathologic acid exposure off medications. Overall, the preferred strategy to evaluate patients with persistent GERD symptoms on acid suppression therapy should be pH testingoff medications. (Sourc...
Source: Journal of Gastrointestinal Surgery - March 11, 2019 Category: Surgery Source Type: research

Lifetime-filtered laser-induced exciplex fluorescence for crosstalk-free liquid-vapor imaging
Laser-induced exciplex fluorescence is a well-established technique for liquid-vapor imaging in evaporating sprays that offers phase-dependent spectrally separated emission. However, the accuracy of this approach is limited by substantial crosstalk from the liquid to vapor phase signals. This ... (Source: Optics Letters)
Source: Optics Letters - March 8, 2019 Category: Physics Authors: Alber Douglawi Venkat Athmanathan Mikhail N. Slipchenko James R. Gord Terrence R. Meyer Source Type: research

Relationship Between Torticollis and Gastroesophageal Reflux Disorder in Infants.
CONCLUSIONS: The increased likelihood of infants with CMT also having GERD has clinical implications for the pediatric physical therapist. PMID: 30865145 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Source: Physical Therapy - March 8, 2019 Category: Physiotherapy Authors: Bercik D, Diemer S, Westrick S, Worley S, Suder R Tags: Pediatr Phys Ther Source Type: research

Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for obesity (YOMEGA): a multicentre, randomised, open-label, non-inferiority trial
This study is registered with ClinicalTrials.gov, number NCT02139813, and is now completed.FindingsFrom May 13, 2014, to March 2, 2016, of 261 patients screened for eligibility, 253 (97%) were randomly assigned to OAGB (n=129) or RYGB (n=124). Five patients did not undergo their assigned surgery, and after undergoing their surgery 14 were excluded from the per-protocol analysis (seven due to pregnancy, two deaths, one withdrawal, and four revisions from OAGB to RYGB) In the per-protocol population (n=117 OAGB, n=117 RYGB), mean age was 43·5 years (SD 10·8), mean BMI was 43·9 kg/m2 (SD 5·6), 176 ...
Source: The Lancet - March 7, 2019 Category: General Medicine Source Type: research

Lacrimal Drainage Obstruction and Gastroesophageal Reflux Disease: A Nationwide Longitudinal Cohort Study
This study aimed to evaluate the association between gastroesophageal reflux disease (GERD) and development of lacrimal drainage obstruction (LDO). Background: It has been hypothesized that GERD may contribute toward the development of LDO. Study: This was a retrospective study of Koreans aged 40 to 79 years registered in the Korean National Health Screening Cohort from 2002 to 2013. Incident cases of LDO were identified according to the Korean Classification of Disease. We compared hazard ratios (HRs) for LDO between 22,570 patients with GERD and 112,850 patients without GERD by 1:5 propensity score-matched analysis...
Source: Journal of Clinical Gastroenterology - March 7, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Unilateral Versus Bilateral Lung Transplantation: Do Different Esophageal Risk Factors Predict Chronic Allograft Failure?
Conclusion: The type of LTx performed seems to lead to different risk factors for the development of o-CLAD. Physicians should be aware of these differences, as they may need to be taken into account when managing patient’s post-LTx. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 7, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Gastro-oesophageal reflux in children: surgical management
Publication date: Available online 5 March 2019Source: Surgery (Oxford)Author(s): Dhanya Mullassery, Matthew O. JonesAbstractGastro-oesophageal reflux disease (GORD) is symptomatic reflux of gastric contents into the oesophagus. Factors predisposing to GORD are loss of the physiological antireflux barrier and anatomic abnormalities of the oesophagus or diaphragm. Conservative measures and medical management results in resolution of symptoms in a majority of children. Surgery is indicated in the event of failure of medical management or severe complications. Surgical procedures include open or laparoscopic fundoplication in...
Source: Surgery (Oxford) - March 6, 2019 Category: Surgery Source Type: research

Why chronic cough in children is different
Publication date: Available online 6 March 2019Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Ahmad Kantar, Manuela SeminaraAbstractRecently, there have been robust changes in our knowledge of the neurophysiology of cough and novel clinical etiologies. Specifically, cough hypersensitivity in adults and protracted bacterial bronchitis (PBB) in children have been increasingly investigated, and differences between chronic cough in children and adults have been widely reported. In young children, postinfectious cough, bronchiectasis, airway malacia, PBB, and asthma appear to be the main causes of cough; however, b...
Source: Pulmonary Pharmacology and Therapeutics - March 6, 2019 Category: Respiratory Medicine Source Type: research

Quantitative femtosecond, two-photon laser-induced fluorescence of atomic oxygen in high-pressure flames
Quantitative femtosecond two-photon laser-induced fluorescence of atomic oxygen was demonstrated in an H_2/air flame at pressures up to 10   atm. Femtosecond excitation at 226.1   nm was used to pump the 3pP3_J^ ′ =0,1,2 ← ← 2pP3_J^ ′ ′ =0,1,2 electronic ... (Source: Applied Optics)
Source: Applied Optics - March 6, 2019 Category: Physics Authors: K. Arafat Rahman Venkat Athmanathan Mikhail N. Slipchenko Sukesh Roy James R. Gord Zhili Zhang Terrence R. Meyer Source Type: research

Gastroesophageal Reflux Induces Protein Adducts in the Esophagus.
PMID: 30827415 [PubMed - in process] (Source: Molecular Medicine)
Source: Molecular Medicine - March 6, 2019 Category: Molecular Biology Authors: Caspa Gokulan R, Adcock JM, Zagol-Ikapitte I, Mernaugh R, Williams P, Washington KM, Boutaud O, Oates JA, Dikalov SI, Zaika AI Tags: Cell Mol Gastroenterol Hepatol Source Type: research

Comparison of Partial vs Total Fundoplication for the Treatment of Gastroesophageal Reflux Disease
This randomized clinical trial attempts to determine whether partial or total fundoplication is superior for treating gastroesophageal reflux disease. (Source: JAMA Surgery)
Source: JAMA Surgery - March 6, 2019 Category: Sports Medicine Source Type: research

Similar Effectiveness of Total and 270 ° Posterior Fundoplication for Gastroesophageal Reflux Disease
This study confirms the results of a randomized clinical trial of open total and posterior partial fundoplication with 2 decades of follow-up, which showed that the 2 procedures result in similar control of reflux. The results of the study by Håkanson et al are also supported by randomized trials and meta-analysis. (Source: JAMA Surgery)
Source: JAMA Surgery - March 6, 2019 Category: Sports Medicine Source Type: research

Screening for Barrett's Esophagus--Balancing Clinical Value and Cost-effectiveness.
Authors: Patel A, Gyawali CP Abstract In predisposed individuals with long standing gastroesophageal reflux disease (GERD), esophageal squamous mucosa can transform into columnar mucosa with intestinal metaplasia, commonly called Barrett's esophagus (BE). Barrett's mucosa can develop dysplasia, which can be a precursor for esophageal adenocarcinoma (EAC). However, most EAC cases are identified when esophageal symptoms develop, without prior BE or GERD diagnoses. While several gastrointestinal societies have published BE screening guidelines, these vary, and many recommendations are not based on high quality evidenc...
Source: Journal of Neurogastroenterology and Motility - March 6, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Surgical outcomes and risk assessment for anastomotic complications after laparoscopic proximal gastrectomy with double-flap technique for upper-third gastric cancer
This study was a retrospective review aimed to demonstrate details of surgical outcomes and to assess risk factors for anastomotic complications using pre-operative CT image after LPG with DFT (LPG –DFT).MethodsPatient background data, surgical outcomes, post-operative courses, and complications for patients who underwent LPG –DFT from January 2013 to June 2017 were collected. In addition to the details of short-term outcomes, risk factors for anastomotic stricture and gastroesophageal reflux were analyzed.ResultsThe study sample was 147 patients, including 139 patients with upper-third gastric cancer and 8 pat...
Source: Gastric Cancer - March 6, 2019 Category: Gastroenterology Source Type: research

CuCl/bpy-promoted unusual Z-stereoselective synthesis of trichloroacetic acid phenyl ester for Hirshfeld surface analysis and DFT study
Publication date: Available online 2 March 2019Source: Journal of Molecular StructureAuthor(s): Ram Kumar Tittal, Ram Nath Ram, Ayushi Nirwan, Vikas D. Ghule, Satish KumarAbstractA trichloromethyl ester devoid of suitably substituted CC bond, any leaving group or a H-atom at the β-position to the radical, which are otherwise known for ATRA/ATRC, 1,2-rearrangement/fragmentation or simple 1,2-H shift respectively, in a reaction of trichloro-acetic acid phenyl ester with 2 mol equiv CuCl/bpy in reflux DCE or benzene under inert N2 condition resulted to stereoselective synthesis of Z-2,3-dichloro-but-2-enedioic acid dip...
Source: Journal of Molecular Structure - March 5, 2019 Category: Molecular Biology Source Type: research

Gastro-oesophageal reflux in children: surgical management
Gastro-oesophageal reflux disease (GORD) is symptomatic reflux of gastric contents into the oesophagus. Factors predisposing to GORD are loss of the physiological antireflux barrier and anatomic abnormalities of the oesophagus or diaphragm. Conservative measures and medical management results in resolution of symptoms in a majority of children. Surgery is indicated in the event of failure of medical management or severe complications. Surgical procedures include open or laparoscopic fundoplication in children with normal neurology; fundoplication with or without vagotomy and pyloroplasty; surgical feeding jejunostomy and o...
Source: Surgery (Medicine Publishing) - March 5, 2019 Category: Surgery Authors: Dhanya Mullassery, Matthew O. Jones Tags: Paediatric surgery – I Source Type: research

Possible application of trefoil factor family peptides in gastroesophageal reflux and Barrett’s esophagus
Publication date: Available online 1 March 2019Source: PeptidesAuthor(s): Adam Fabisiak, Adrian Bartoszek, Grzegorz Kardas, Natalia Fabisiak, Jakub FichnaAbstractGastroesophageal reflux disease (GERD) is a chronic disorder of the digestive tract characterised mainly by a heartburn. Being one of the most common gastrointestinal diseases, the prevalence of GERD reaches up to 25.9% in Europe. Barrett’s esophagus (BE) is an acquired condition characterized by the replacement of the normal stratified squamous epithelium with metaplastic columnar epithelium. BE is believed to develop mainly from chronic GERD and is the mos...
Source: Peptides - March 4, 2019 Category: Biochemistry Source Type: research

Altered T Cell Migratory Capacity in the Progression from Barrett Oesophagus to Oesophageal Adenocarcinoma
This study examined the chemokine networks governing T cell migration to oesophageal tissue during disease progression. Here, we have identified that circulating T cells in OAC patients, exhibit impaired migratory capacity with decreased frequencies of Th1-associated CXCR3+ and Th17-associated CCR6+ cells. Despite the abundance of Th1 chemokines RANTES (CCL5) and MIP-1 α (CCL3) in OAC tumour, enrichments of intratumoural T cells expressing corresponding receptors were not observed. These data suggest that T cell infiltration of oesophageal tissue is compromised in OAC and suggest that future therapies targeting T cel...
Source: Cancer Microenvironment - March 4, 2019 Category: Cancer & Oncology Source Type: research

Overview of eosinophilic oesophagitis.
Abstract Eosinophilic oesophagitis is a disease that has been recognized in the past 30 years. It causes dysphagia and other symptoms of oesophageal dysfunction. Eosinophilic oesophagitis presents either with a chronic feeling of difficulty swallowing, with food moving slowly through the oesophagus, or as an acute food bolus obstruction requiring emergency attention. Patients may also experience chest pain at this time. It is an inflammatory disorder, thought to be driven by food or environmental antigens, where the most distinctive cell type is eosinophils. Eosinophilic oesophagitis is mediated through a local Ig...
Source: British Journal of Hospital Medicine - March 2, 2019 Category: Internal Medicine Authors: Attwood SE Tags: Br J Hosp Med (Lond) Source Type: research

Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate
Publication date: Available online 1 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Arun Kumar Awasthi, Lalit Kumar, Punit Tripathi, Madhava Golla, Cirandur Suresh Reddy, Pramod KumarAbstractPantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopeia (USP) specified six impurities, viz.; impurities A, B, C, D, E and F, respectively for this active pharmaceutical in...
Source: Journal of Pharmaceutical Analysis - March 1, 2019 Category: Drugs & Pharmacology Source Type: research

Association between tea consumption and gastroesophageal reflux disease: A meta-analysis: Erratum
No abstract available (Source: Medicine)
Source: Medicine - March 1, 2019 Category: Internal Medicine Tags: Erratum Source Type: research

Gastroesophageal reflux disease
No abstract available (Source: Gastroenterology Nursing)
Source: Gastroenterology Nursing - March 1, 2019 Category: Nursing Tags: Departments: Focus on Clinical Assessment Source Type: research

Co-existing pediatric ureteropelvic junction obstruction and vesicoureteric reflux: Prevalence and implications
Conclusion: The prevalence of VUR was 25.9% in this study and 33.3% in ≤1 year age group. There was a loss of function in delayed presenters with associated ipsilateral VUR. There was delayed drainage postpyeloplasty in patients with VUR. A preoperative voiding cystourethrogram should be done in children <1 year age before pyeloplasty so that associated VUR if detected can be concurrently managed along with pyeloplasty and preserve nephrons affected by the dual pathology. (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - March 1, 2019 Category: Surgery Authors: Shalini Hegde Prema Menon Katragadda Lakshmi Narasimha Rao Source Type: research

Long-Term Effectiveness of Antireflux Surgery in Esophageal Atresia Patients
Conclusion In the long term, ARP is not effective in reducing GERD as measured as Ri in EA patients. The ARP group had significantly lower weight at 1 and 7 years of age than the non-ARP group, but this was not the case at the age of 15. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - March 1, 2019 Category: Surgery Authors: J önsson, Linus Dellenmark-Blom, Michaela Enoksson, Oskar Friberg, Lars G öran Gatzinsky, Vladimir Sandin, Anders Abrahamsson, Kate Tags: Original Article Source Type: research

[Barrett-Screening: Rational, current concepts and perspectives].
ockel I Abstract Though showing an increasing incidence over the past 20 years, esophageal adenocarcinoma (EAC) remains a rather uncommon cancer (i. e., compared to colorectal and gastric cancer). Once detected, the prognosis of this cancer entity is still very poor. Hence, in spite of some unfavorable prerequisites to systematic screening, the development of a screening concept for Barrett's esophagus (BE) and EAC seems worthwhile. Nowadays, screening for BE and EAC is based on conventional endoscopy, mostly conducted individually in patients with reflux complaints (gastroesophageal reflux disease-GERD). B...
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Weismüller J, Thieme R, Hoffmeister A, Weismüller T, Gockel I Tags: Z Gastroenterol Source Type: research

Peroral endoscopic myotomy versus pneumatic dilation - result from a retrospective study with 1-year follow-up.
Abstract BACKGROUND AND AIMS:  On the basis of lesser rates of major adverse events and a short-term efficacy as Heller's myotomy, there is a growing enthusiasm in favor of peroral endoscopic myotomy (POEM), whereas study comparing POEM and pneumatic dilatation (PD) is quite rare. The aim of this study was to evaluate the efficacy of POEM and PD in Chinese achalasia patients in a retrospectively designed study. METHODS:  Patients with achalasia, who underwent either PD (n = 26) or POEM (n = 40) were retrospectively recruited from September 2010 through March 2016 at a single tertiary cente...
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Zheng Z, Zhao C, Su S, Fan X, Zhao W, Wang B, Jin H, Zhang L, Wang T, Wang B Tags: Z Gastroenterol Source Type: research

Eosinophilic esophagitis: Pathophysiology, diagnosis, and management.
Abstract Eosinophilic esophagitis (EoE) is a multifactorial esophageal inflammation, with a genetic predisposition, which combines a deficient esophageal mucosal barrier, an abnormal immune reaction to environmental allergens mediated by Th2 interleukins, immediate esophageal lesions and dysmotility, with secondary remodeling and fibrosis. Symptoms include reflux, abdominal pain, and food impaction, with a variation according to age. Fibroscopy shows major and minor endoscopic and histologic criteria, with a mucosal count≥15 eosinophils/high power field (Eo/hpf). A new entity has been defined, where gastroesoph...
Source: Archives de Pediatrie - February 28, 2019 Category: Pediatrics Authors: Vinit C, Dieme A, Courbage S, Dehaine C, Dufeu CM, Jacquemot S, Lajus M, Montigny L, Payen E, Yang DD, Dupont C Tags: Arch Pediatr Source Type: research

Per-Oral Pyloromyotomy (POP) for Medically Refractory Post-Surgical Gastroparesis
ConclusionPOP is a safe and effective endoscopic therapy for patients with psGP. POP should be considered a reasonable first-line option for patients with medically refractory psGP and may allow stomach preservation. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - February 26, 2019 Category: Surgery Source Type: research

A Cross-sectional Survey of the Clinical Manifestations and Underlying Illness of Cough
Conclusion: The specific items on our questionnaire relating to patient characteristics, complications, and triggers of cough, represent useful tools for diagnosing the primary disease producing cough. (Source: In Vivo)
Source: In Vivo - February 25, 2019 Category: Research Authors: OTOSHI, T., NAGANO, T., FUNADA, Y., TAKENAKA, K., NAKATA, H., OHNISHI, H., NISHIUMA, T., NAKAJIMA, T., KAGESHITA, T., TSUCHIYA, T., YAMAMOTO, M., KOBAYASHI, K., NISHIMURA, Y. Tags: Clinical Studies Source Type: research

Exam 1: Low Prevalence of Suspected Barrett's Esophagus in Gastroesophageal Reflux Disease Without Alarm Symptoms
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 25, 2019 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research

[Functional Dyspepsia].
Abstract Dyspepsia is a common problem, and when dyspeptic symptoms develop within a short period of time, organic diseases such as gastroesophageal reflux disease, peptic ulcer diseases, pancreatoduodenal diseases, and gastrointestinal cancers should be suspected. Furthermore, functional dyspepsia (FD) should be considered if chronic or recurrent symptoms persist after eliminating underlying disease. FD is classified as epigastric pain syndrome (EPS) or postprandial distress syndrome (PDS), but these two conditions may overlap. Patients with the EPS subtype can be treated with proton pump inhibitors (PPIs), where...
Source: Korean J Gastroenter... - February 25, 2019 Category: Gastroenterology Authors: Oh JH, Kwon JG Tags: Korean J Gastroenterol Source Type: research

[Gastroesophageal Reflux Disease].
Abstract Gastroesophageal reflux disease (GERD) is a condition that develops when reflux of stomach contents causes troublesome symptoms and/or complications. The prevalence of GERD is increasing worldwide and in Asia-Pacific. The latest Korean guidelines for GERD were published in 2012, and several international guidelines and consensus statements for the management of GERD have also been recently published. Here, we review these guidelines and consensus statements in order to provide a better understanding of the diagnosis and treatment of GERD. PMID: 30845382 [PubMed - in process] (Source: Korean J Gastroenter...)
Source: Korean J Gastroenter... - February 25, 2019 Category: Gastroenterology Authors: Park CH, Lee SK Tags: Korean J Gastroenterol Source Type: research

Exam 1: Low Prevalence of Suspected Barrett's Esophagus in Patients With Gastroesophageal Reflux Disease Without Alarm Symptoms
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - February 25, 2019 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activity Source Type: research

Perspectives on the interlinked nature of systemic sclerosis and reflux disease.
Authors: Chwiesko A, Kowal-Bielecka O, Sierakowski S Abstract INTRODUCTION: Systemic sclerosis (SSc) is a multisystem connective tissue disease, characterized by chronic inflammation and vascular changes that result in esophageal smooth muscle atrophy and fibrosis. Subsequent progressive loss of peristalsis in the distal esophagus and loss of lower esophageal sphincter function lead to problems with the protective barrier and exposure of sensitive tissues to the gastroduodenal contents, a disorder called reflux disease. Areas covered: Depending on the range, nature and symptoms of the disease, the term 'reflux dise...
Source: Expert Review of Gastroenterology and Hepatology - February 24, 2019 Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research

Intrauterine left gastric artery infarct as the primary etiology for congenital nonsyndromic microgastria
We present the first case of a newborn female patient diagnosed with isolated microgastria caused by a vascular accident in utero with absence of the left gastric artery. The patient had a 2 month history of gastroesophageal reflux, postprandial emesis, diarrhea, and failure to thrive. It was sequentially treated with nutritional optimization via a Bishop-Koop type proximal jejunal feeding stoma, and subsequent Hunt-Lawrence gastric augmentation. The patient has recovered from surgery and caught up in terms of weight expectancy for age. (Source: Journal of Pediatric Surgery Case Reports)
Source: Journal of Pediatric Surgery Case Reports - February 23, 2019 Category: Surgery Source Type: research

Upper Esophageal Sphincter Dysfunction in Gastroesophageal Reflux Disease
(Source: Dysphagia)
Source: Dysphagia - February 23, 2019 Category: Speech-Language Pathology Source Type: research

Facile reflux synthesis of polyethyleneimine ‐capped fluorescent carbon dots for sequential bioassays toward Cu2+/H2S and its application for a logic system
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - February 22, 2019 Category: Biochemistry Authors: Zi ‐Han Chen, Xin‐Yue Han, Zi‐Yang Lin, Yu‐Lin Fan, Guoyue Shi, Shengqiang Zhang, Min Zhang Tags: Original Article Source Type: research

Objective tongue color and gastroesophageal reflux disease: Cross ‐sectional study
This study was done to investigate the utility of tongue color (TC) and FSSG in the diagnosis of GERD.MethodsA total of 886 healthy Japanese residents aged 28 –86 years had a photograph of the tongue taken, completed the FSSG, and underwent esophagogastroduodenoscopy. FSSG ≥8 was defined as GERD, mucosal break on endoscopy as reflux esophagitis (RE), and no erosive esophagitis as non‐erosive reflux disease (NERD). TC was measured using the device‐ independent International Commission on Illumination (CIE) 1976 L*a*b* color space standards at four points.ResultsA total of 152 (17.2%) of the subjec...
Source: Traditional and Kampo Medicine - February 22, 2019 Category: Complementary Medicine Authors: Mosaburo Kainuma, Norihiro Furusyo, Yoshihisa Urita, Hiroaki Ikezaki, Kazuya Ura, Toshiya Nakaguchi, Takao Namiki Tags: ORIGINAL ARTICLE Source Type: research

Facile reflux synthesis of polyethyleneimine ‐capped fluorescent carbon dots for sequential bioassays toward Cu2+/H2S and its application for a logic system
This article is protected by copyright. All rights reserved (Source: Biotechnology and Applied Biochemistry)
Source: Biotechnology and Applied Biochemistry - February 22, 2019 Category: Biochemistry Authors: Zi ‐Han Chen, Xin‐Yue Han, Zi‐Yang Lin, Yu‐Lin Fan, Guoyue Shi, Shengqiang Zhang, Min Zhang Tags: Original Article Source Type: research

A case report of esophageal actinomycosis in an immunocompetent patient and review of the literature.
We report a case of esophageal actinomycosis in an immunocompetent 23-year-old man. The patient was admitted with symptoms of gastro-esophageal reflux disease (GERD), that had subsequently worsened. Histological and microbiological investigations revealed the presence of Actinomyces spp. A review of the literature regarding the clinical features, diagnosis, and management of this infection is also discussed. PMID: 30785207 [PubMed - as supplied by publisher] (Source: New Microbiologica)
Source: New Microbiologica - February 21, 2019 Category: Microbiology Tags: New Microbiol Source Type: research

Prevalence and factors associated with gastroesophageal reflux disease in southern India: A community-based study
ConclusionSymptomatic GERD was found in 8.2% of respondents in this representative southern Indian community, being more prevalent in urban residents, women, older, and obese individuals. (Source: Indian Journal of Gastroenterology)
Source: Indian Journal of Gastroenterology - February 21, 2019 Category: Gastroenterology Source Type: research

Host factors influence Barrett ’s carcinogenesis: findings from a mouse gastroduodenal reflux model
ConclusionsWe showed the effects of TCA in cancer progression in vitro. However, Barrett ’s adenocarcinoma onset rates differ between mice and rats despite undergoing similar reflux stimulation including taurine-conjugated bile acids being detected in mouse bile juice. These results suggest that host factors seem to influence Barrett’s carcinogenesis. (Source: Esophagus)
Source: Esophagus - February 21, 2019 Category: Gastroenterology Source Type: research

Nutrient drink test: A promising new tool for irritable bowel syndrome diagnosis.
CONCLUSION: A high NDT merits further evaluation as a diagnostic tool for IBS. PMID: 30809083 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - February 21, 2019 Category: Gastroenterology Authors: Estremera-Arevalo F, Barcelo M, Serrano B, Rey E Tags: World J Gastroenterol Source Type: research

[Guidelines of the German Respiratory Society for Diagnosis and Treatment of Adults Suffering from Acute, Subacute and Chronic Cough].
Authors: Kardos P, Dinh QT, Fuchs KH, Gillissen A, Klimek L, Koehler M, Sitter H, Worth H Abstract The present 2019 S2k consensus guideline of the German Respiratory Society was written - in contrast to the predecessor more general S3 guidelines from 2004 and 2010 - for pneumologists, since 2014 the German College of General Practitioners and Family Physicians (DEGAM) published his own cough guidelines.The guideline contains 48 recommendations agreed by consensus and 16 statements, which are explained in the background text in the following nine chapters: epidemiology, physiology, classification, acute, subacute or...
Source: Pneumologie - February 20, 2019 Category: Respiratory Medicine Tags: Pneumologie Source Type: research