Safety considerations when managing gastro-esophageal reflux disease in infants.
Authors: Vandenplas Y, Levy E, Simon M Abstract INTRODUCTION: Gastro-esophageal reflux disease (GERD) in infants is worldwide diagnosed with increasing frequency, resulting in an increasing number of infants exposed to treatment. In this review, we focus on the safety of therapeutic options. AREAS COVERED: English articles were searched from 1990 until May 2020 in PubMed and Google Scholar. Evidence suggests that non-pharmacological treatment is often effective and safe. Guidelines restrict pharmacological treatment to acid-suppressive medication, which is associated with adverse effects, often related to gastr...
Source: Expert Opinion on Drug Safety - October 30, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

The Usefulness of the Measurement of Esophagogastric Junction Distensibility by EndoFLIP in the Diagnosis of Gastroesophageal Reflux Disease.
Authors: Lee JM, Yoo IK, Kim E, Hong SP, Cho JY Abstract Background/Aims: : Increased esophagogastric junction (EGJ) relaxation is the most important mechanism involved in gastroesophageal reflux disease (GERD). An endoscopic functional luminal imaging probe (EndoFLIP®) is a device used to quantify EGJ distensibility in routine endoscopy. The aim of the current study was to assess the usefulness of EndoFLIP® for the diagnosis of GERD compared to normal controls. Methods: We analyzed EndoFLIP® data from 204 patients with erosive reflux disease (ERD), 310 patients with nonerosive reflux disease (NERD)...
Source: Gut and Liver - October 30, 2020 Category: Gastroenterology Tags: Gut Liver Source Type: research

[Esophageal pH-impedance monitoring of reflux patterns in non-erosive reflux disease, reflux hypersensitivity and functional heartburn].
Abstract OBJECTIVE: To analyze the differences in reflux patterns in 24-hour esophageal pH-impedance monitoring in patients with non-erosive reflux disease (NERD), reflux hypersensitivity (RH) and functional heartburn (FH) and explore the possible mechanism of symptoms in patients with heartburn and negative endoscopic findings. METHODS: Seventy-nine patients with heartburn as the main symptoms but negative endoscopic findings, including 35 with NERD, 16 with RH and 28 with FH, were enrolled in this study.All the patients underwent 24-h esophageal pH-impedance monitoring and esophagogastroscopy, and the resul...
Source: Journal of Southern Medical University - October 30, 2020 Category: Universities & Medical Training Authors: Zhang A, Yao W, Di J, Cui M, Zhang M, Zhang J Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

Efficacy of DA-5204 (Stillen 2X) for patients with gastroesophageal reflux disease: A randomized, double-blind, placebo-controlled pilot study
Conclusion: Combined therapy with PPI and DA-5204 has no additional effect on the endoscopic healing rate compared to PPI alone. However, it may be beneficial in resolving minimal change. (Source: Medicine)
Source: Medicine - October 29, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Gastroesophageal Reflux Disease and Barrett Esophagus in the Elderly
As our population continues to age, the early diagnosis and optimal management of patients with gastroesophageal reflux disease becomes paramount. Maintaining a low threshold for evaluating atypical symptoms in this population is key to improving outcomes. Should patients develop complications including severe esophagitis, peptic stricture, or Barrett esophagus, then a discussion of medical, endoscopic, and surgical treatments that accounts for patient ’s comorbidities and survival is important. Advances in screening, surveillance, and endoscopic treatment of Barrett esophagus have allowed us to dispel concerns of fu...
Source: Clinics in Geriatric Medicine - October 29, 2020 Category: Geriatrics Authors: Fouad Otaki, Prasad G. Iyer Source Type: research

Community-dwelling older adults ’ awareness of the inappropriate use of proton pump inhibitors
Proton pump inhibitors (PPIs) are effective in treating gastroesophageal reflux, peptic ulcers, and esophagitis. However, the long-term use of PPIs by older adults is associated with adverse health outcomes. T... (Source: BMC Geriatrics)
Source: BMC Geriatrics - October 29, 2020 Category: Geriatrics Authors: Mohammad Rababa and Abeer Rababa ’h Tags: Research article Source Type: research

Feeding patterns and outcomes of enterally tube fed paediatric kidney transplant recipients
ConclusionsSeventy percent of children stopped ETF by a median of 6 weeks post-renal transplant. A good nutritional status pre-transplant may reduce the duration of ETF following transplantation. Four children experienced behavioural feeding issues post-transplant and required further specialist support. Future multi-centre research is required to support these findings to provide a more robust indication of time to achieve full oral feeding.Graphical abstract (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - October 28, 2020 Category: Urology & Nephrology Source Type: research

Effect of continuous positive airway pressure on gastroesophageal reflux in patients with  obstructive sleep apnea: a meta-analysis
In this study, we utilized meta-analysis to investigate whether or not CPAP tre atment reduces the incidence of reflux.MethodsTwo independent reviewers obtained the data sources from the database of PubMed, Elsevier, Cochrane library, and CNKI  using search terms, and then filtered the target articles based on the inclusion and exclusion criteria. RevMan (version 5.3) and STATA (version 12.0) were used for data synthesis. The effect of CPAP treatment on GERD was studied by calculating the weighted mean difference (WMD) and standard devia tion (SD) before and after CPAP treatment.ResultsTen studies involving a tot...
Source: Sleep and Breathing - October 28, 2020 Category: Respiratory Medicine Source Type: research

30-day Readmissions After Acute Exacerbations of COPD: How Relevant Are Comorbidities?
Conclusions: Cardiovascular diseases were highly prevalent and acute heart failure was an important cause of 30-day readmission among AECOPD patients. GERD may complicate AECOPD recovery and patients with previous stroke may be at higher risk of a fatal outcome. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Freitas, C., Dias, J., Leuschner, P. Tags: Monitoring airway disease Source Type: research

Clusters of comorbidities in idiopathic pulmonary fibrosis
Conclusions: The majority of IPF patients suffered from multimorbidity and cardiovascular, respiratory and gastro-intestinal comorbidities were common. The four comorbidity clusters could represent phenotypes in patients with IPF. Prevention and treatment of comorbidities will benefit from increased awareness and knowledge of comorbidities in patients with IPF. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Prior, T. S., Hoyer, N., Hilberg, O., Shaker, S., Davidsen, J. R., Rasmussen, F., Bendstrup, E. Tags: Idiopathic interstitial pneumonias Source Type: research

Role and impact of chronic cough in obese individuals from the general population
The aim of this study was to investigate the role and impact of chronic cough in obese individuals from the general population.For this purpose we recorded chronic cough, body mass index and other clinical conditions associated with chronic cough in a nested cohort of 33,577 adults from the Copenhagen General Population Study. Mediation analyses were used to investigate the causative pathway from obesity to chronic cough. Individuals with asthma and chronic obstructive pulmonary disease were excluded from the statistical analyses.The adjusted odds ratios for chronic cough in the general population were 1.38 (1.22-1.56) in ...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Landt, E., Colak, Y., Nordestgaard, B. G., Lange, P., Dahl, M. Tags: Epidemiology Source Type: research

The association between airflow limitation and dyspnea and comorbidity related to COPD in the Nagahama study
Background: Comorbidities of COPD may be affected with underlying conditions of COPD, such as older age, male sex, or smoking history. Meanwhile, evidence on the relationship between airflow limitation (AL), underlying conditions, and comorbidities in preclinical COPD is limited. Moreover, the effect of comorbidities on dyspnea is unclear. The aim of this study is to reveal associations between comorbidities and AL or dyspnea.Methods: This community-based Nagahama study in Japan enrolled 9789 inhabitants. Subjects under 40 years of age or having asthma were excluded. We conducted self-reporting questionnaires and lung func...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kogo, M., Sato, S., Muro, S., Nomura, N., Tashima, N., Oguma, T., Murase, K., Kawaguchi, T., Tabara, Y., Matsuda, F., Chin, K., Hirai, T., Matsumoto, H. Tags: Epidemiology Source Type: research

Protein expression of TRP channels in the esophagus of patients with gastroesophageal reflux (GER)-associated cough
We reported an increased gene expression of TRPV1 and TRPV4 in the esophagus of GER patients with cough ERS 2019. However, association between protein expression of these channels in the esophagus and GER-associated cough is still unknown.Method: We prospectively recruited untreated GER patients with (n=32, C+) and without (n=5, C-) cough. Esophageal endoscopy was performed to determine the presence and severity of reflux esophagitis (RE), and to obtain biopsy specimens, which were examined for TRPV1 and TRPV4 protein expression by western blot analysis.Result: Age, sex distribution, smoking history, prevalence/severity of...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Takeda, N., Ueda, T., Go Yap, J. M., Nishiyama, H., Kurokawa, R., Fukumitsu, K., Kanemitsu, Y., Kubota, E., Kamiya, T., Takemura, M., Niimi, A. Tags: Allergy and immunology Source Type: research

Mepolizumab in real-life treatment of severe eosinophilic asthma
Conclusion: Our experience confirms effect of mepolizumab treatment to improving of astma control and reducing of OCS use in real-life severe eosinophilic astma patients. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Volakova, E., Zatloukal, J. Tags: Airway pharmacology and treatment Source Type: research

Effetiveness of biological treatment in severe asthma difficult to control (SADC)
Conclusions: Biological treatments are effective in SADC and are well tolerated.Comorbidities are common in the SADC.We have to keep learning about biological therapies to improve their use. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Moron Ortiz, M. A., Hilares Vera, J., Lancha Dominguez, J., Puchaes Manchon, C., Sanchez-Ramos, J. L., Pereira Vega, A. Tags: Airway pharmacology and treatment Source Type: research

Relation between pulmonary function tests (PFTs) and severe asthma difficult to control
Introduction: The severity of asthma is defined by clinical characteristics and PFTs. There may be some mismatch between the PFTs and the clinic of patients with Severe Asthma Difficult to Control (SADC). Biological treatment: Omalizumab (O), Mepolizumab (M) and Benralizumab (B) may improve in PFTs in patients with SADC.Objectives: Determine the degree of bronchial obstruction in patients with SADC. Show relationship between the degree of obstruction and clinical control of asthma, as measured by the ACT questionnaire. Assess the possible improvement of PFTs after biological treatment.Material and Methods: We evaluated spi...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Urizar Catalan, B. E., Moron Ortiz, M., Puchaes Manchon, C., Romero Lopez, J., Pereira-Vega, A., Sanchez Ramos, J. L. Tags: Monitoring airway disease Source Type: research

Personalizing asthma care base on Asthma Control Test (ACT) correlation with treatment of asthma comorbidities in a Malaysian cohort
Introduction: Optimized asthma control is evidenced by ACT score of 20 and above. However, poor asthma control can be due to the co-morbidities. We sought to correlate ACT score and treatment of asthma co-morbidities in order to achieve optimal asthma control.Methods: Retrospective analysis of the baseline and subsequent visits (after 6 months and 1 year) of patients who attended our chest clinic from 2015 till 2018. Besides clinical assessments, patients also filled up the Asthma Control Test (ACT) score form, and were given appropriate treatment. Patients’ information and clinical data were obtained from the clinic...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Yaqeen, N., Ismail, A. I. Tags: Monitoring airway disease Source Type: research

Effect of obstructive sleep apnea on asthma control
Aim: To assess relationship between obstructive sleep apnea (OSA) risk and uncontrolled asthma.Methods: Asthma control test (ACT) and Berlin Questionnaire (BQ) was performed on subjects with asthma who had regular inhaler use with appropriate technique and did not have an exacerbation in the last 8 weeks. Demographic and clinical characteristics and OSA-risk of subjects were compared between controlled and uncontrolled asthmatics. Association between asthma control and OSA risk was assessed.Results: Asthmatics aged 44.5 ± 11.5 years (male/female=37/100) were included in the study. Asthma was under control (ACT ≥2...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Mat, D. O., Fırat, S., Aksu, K., Aksu, F., Sahin Duyar, S. Tags: Monitoring airway disease Source Type: research

Blood eosinophil count as a predictor of treatment response in adult patients with chronic cough
The new 2019 ERS guidelines on the diagnosis and treatment of chronic cough (CC) reported the lack of evidence on the role of blood eosinophil count (BEC) as a predictor of treatment response.The study was aimed to assess a relationship between BEC and the efficacy of CC treatment.Data on 142 non-smoking patients with CC and a normal chest x-ray, prospectively observed between 2014 and 2019, were analyzed. At least a 20 mm decrease in CC severity measured in visual analogue scale (VAS) was classified as good response to CC treatment. Receiver operating characteristic (ROC) curve was constructed to evaluate usefulness of BE...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Rybka, A., Dabrowska, M., Grabczak, E. M., Bialek-Gosk, K., Klimowicz, K., Truba, O., Krenke, R. Tags: Airway pharmacology and treatment Source Type: research

Determination of levels of markers of systemic inflammation in patients with chronic bronchitis in combination with concomitant gastroesophageal reflux disease
Chronic bronchitis (CB) combined with gastroesophageal reflux disease (GERD) is an example of a combined pathology that leads to an aggravating course of each other. The prolonged chronic inflammatory process triggers the activation of systemic inflammation, so determining the markers of inflammation in patients with CB in combination with GERD is relevant for studying the disease course and effective treatment correction.Aim: Evaluation of serum levels TNF-α and CRP in patients with CB in combination with GERD.Materials and Methods: 34 patients with CB with concomitant GERD together with general clinical examination...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Shevchuk-Budz, U., Ostrovskyy, M., Varunkiv, O., Savelikhina, I., Makoyda, I., Ostrovska, K. Tags: Airway cell biology and immunopathology Source Type: research

Bronchoalveolar lavage amylase levels can be a biomarker of aspiration pneumonia
Conclusion: BALF amylase seems to be a useful biomarker for microaspiration. These results suggest microaspiration occurs not only from reflux, but also from droplets of saliva. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Suzuki, T., Saitou, M., Utano, Y., Utano, K., Niitsuma, K. Tags: Respiratory infections Source Type: research

Prevalence of gastroesophageal reflux symptoms in obstructive sleep apnea
Introduction: Obstructive sleep apnea (OSA) and gastroesophageal reflux (GER) disease are both common diseases sharing overlapping signs and symptoms. Data on the prevalence of GER symptoms in patients with OSA are limited.Aim: To investigate the prevalence of GER symptoms in a broad number of patients with OSA.Methods: This was a cross-sectional, observational study of 1802 consecutive patients (mean age±SD: 62±12 years, 68% males) evaluated for suspected sleep-disordered breathing. All patients underwent home sleep cardiorespiratory polygraphy, Epworth Sleepiness Scale (ESS) and Gerd Questionnaire (GerdQ), ...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Pini, S., Rizzi, M., Saad, M., Gaboardi, P., Pecis, M., Radovanovic, D., Santus, P. Tags: Sleep and control of breathing Source Type: research

Study to evaluate clinical burden related with oral corticosteroids treatment of severe asthma in Spain (LEVANTE)
Conclusion: The burden of asthma persists without differences between patients receiving maintenance or OCS courses for 6-month follow up (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Munoz Gall, X., Dominguez Ortega, J., Pascual Erquicia, S., Cabrera Lopez, C., Martin Panadero, C. J., Monteagudo Ruiz, G., Resler, G. Tags: Airway pharmacology and treatment Source Type: research

Impeding progress or a useful test? Impedance studies in paediatric respiratory patients
Conclusion: Impedance studies had a high failure rate. In those in whom they were successful, the result changed little clinical management. Careful consideration should be given to performing impedance studies in the best interests of the child and cost effectiveness. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Selby, L., Heuschkel, R. Tags: Clinical problems Source Type: research

The Role of Barium Swallow in Determining the Aetiology of Bronchiectasis. A RetrospectiveReview
Conclusion: Barium swallow is a safe investigation and its use may reduce rates of idiopathic bronchiectasis and lead to further treatment modalities. The presence of abnormalities tends towards worse lung function, supporting the role of reflux or pulmonary micro-aspirations in bronchiectasis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Campbell, C. D., Rutherford, R. M. Tags: Clinical problems Source Type: research

Respiratory muscle function in patients with gastroesophageal reflux disease with extraesophageal symptoms
Introduction: Prevalence of respiratory muscle dysfunction has been shown to be higher in patients with respiratory diseases than in subjects without, but comprehensive investigations of respiratory muscle function in patients with gastroesophageal reflux disease (GERD) with extraesophageal symptoms have not yet been performed.Methods: We assessed respiratory muscle function of 18 patients with GERD (FVC=101.0±17.5% predicted; 11 females/7 males) and 18 healthy controls (FVC=102.0±9.9% predicted; 11 females/7 males), who were matched for age and BMI. Patients with GERD underwent a combination of postural and ...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Neumannova, K., Zatloukal, J., Horova, P., Michalcikova, T., Dvoracek, M. Tags: Physiotherapists Source Type: research

Non-tuberculous mycobacteria: five year experience
Conclusions: Our results confirme the role of increased prevalence of chronic lung disease and immunosuppressive conditions in the pathogenesis of NTM infection. According with literature, MAC account for the majority of NTM isolated in our hospital. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Conceicao, M., Cunha, A. D., Ferro, R., Guerra, S., Correia, J. B., Reis, A., Torres, A. S. Tags: Respiratory infections Source Type: research

FVC decline in patients with SSc-ILD by use of anti-acid therapy
Conclusion: Post-hoc analyses of data from the SENSCIS trial suggest that the effect of nintedanib on reducing FVC decline in patients with SSc-ILD was similar between patients taking and not taking AAT at baseline. Confounding factors limit interpretation of the differences observed between subgroups based on use of AAT. The effects of GERD and AAT in patients with SSc-ILD warrant further study. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kreuter, M., Nunes, H., Criner, G. J., Sfikakis, P., Stevens, W., Miede, C., Quaresma, M., Alves, M., Raghu, G. Tags: Rare ILD / DPLD Source Type: research

Rerationship between interstitial pneumonia related systemic sclerosis and esophageal motility abnormalities
Interstitial pneumonia and esophageal motility abnormalities (EMAs) are often seen in patients with systemic sclerosis (SSc). SSc-interstitial lung disease(SSc-LLD) is mainly characterized by non-specific interstitial pneumonia(NSIP) and usual interstitial pneumonia(UIP) pattern. But it is not fully understood if the classification of interstitial pneumonia is related to gastroesophageal reflux (GER) events. A total of 74 patients with SSc-ILD who underwent high resolution manometry(HRM) were enrolled retrospectively.The type of esophageal motility was assigned normal esophageal motility(N) group, ineffective esophageal mo...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Hara, K., Yamaguchi, K., Yatomi, M., Tsurumaki, H., Hisada, T., Maeno, T. Tags: Rare ILD / DPLD Source Type: research

Comorbidities in unclassifiable interstitial lung disease
Conclusion: Comorbidities were common in uILD, but the presence of specific comorbidities did not affect survival nor did the cumulative number of comorbidities. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Hyldgaard, C., Torrisi, S., Kronborg-White, S., Ganter, C., Bendstrup, E., Kreuter, M. Tags: Rare ILD / DPLD Source Type: research

Bronchiectasis in children: a risky evolution of recurrent respiratory infection
The most frequent cause of bronchiectasis in children is cystic fibrosis. Several underlying conditions in patients with non-CF bronchiectasis should be excluded: recurrent respiratory infection (RRI), aspiration, ciliary dyskinesia, primary and secondary immunodeficiency, congenital malformations and others.We retrospectively analyzed 155 children with non-CF bronchiectasis attending our department in the last 20 years.In our series, 62.5% had RRI, 13.8% specific diseases (bronchopulmonary dysplasia 4.5%, malformations 7.4%, post infectious bronchiolitis obliterans 1.3%, alpha1antitripsin deficiency 0.6%), 9.1% inhalation...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Cammi, G. M. L., Paradiso, L., Longoni, E., Ghezzi, M., Morelli, M., Farolfi, A., D'Auria, E. C., Zuccotti, G. Tags: Paediatric bronchology Source Type: research

Tracheomalacia: our ten years experience in Milan
Tracheomalacia(TM) is an anomaly of upper respiratory tract characterized by weakness of tracheal walls associated with dynamic collapse during breathing. Tracheo-bronchomalacia(TBM) is the extension of this anomaly to part of bronchial walls.There are many causes of both congenital and acquired TBM: idiophatic, intrinsic defect of cartilagineous portion of the trachea; cardiovascular anomalies or extrinsic compression by heart and vessels anomalies, tumors, lymphonodes or masses; syndromes; prolonged positive pressure ventilation in premature infants with broncho-pulmonary dysplasia. Furthermore it can be a complication o...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Paradiso, L., Cammi, G. M. L., Longoni, E., Ghezzi, M., Morelli, M., Farolfi, A., D'Auria, E. C., Zuccotti, G. Tags: Paediatric bronchology Source Type: research

Idiopathic pulmonary fibrosis and gastroesophageal reflux disease: A population-based case-control study
The objective of this population-based study was to investigate if patients with IPF were at increased risk of GERD exposure(within 5 years prior to the diagnosis) compared to age and sex matched two groups of controls.The two groups of controls were: interstitial lung disease(ILD)other than IPF and subjects with no diagnosed lung disease (population controls).Rochester Epidemiology Project (REP)was used to identify cases of IPF as well as controls (matching between cases and controls 1:2).American Thoracic Society/European Respiratory Society criteria for the diagnosis of IPF were used.A total of 113 IPF cases were identi...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Baqir, M., Vu, A., Moua, T., Vasireddy, A., Chamberlain, A., Frank, R., Ryu, J. Tags: ILD / DPLD of known origin Source Type: research

Idiopathic pulmonary fibrosis and systemic sclerosis-interstitial lung disease: features at admission to a tertiary pulmonology unit
Background: Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-interstitial lung disease (SSc-ILD) are chronic fibrotic disorders that, despite sharing common profibrotic pathways, display differences in epidemilogy and clinical presentation.Objective: To investigate features of IPF and SSc-ILD patients admitted to a tertiary pulmonology unit for a recent onset/worsening dyspnea.Methods: Fourty-one IPF and 39 SSc-ILD patients visited over 1 year were investigated for lung function and comorbidities frequently associated with both conditions.Results: As expected, SSc-ILD were predominantly females and younger (media...
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Vettori, S., Lanza, M., Annunziata, A., Cauteruccio, R., Coppola, A., Di Spirito, V., De Simone, F., Gioia, S., Imitazione, P., Stefanelli, F., Fiorentino, G. Tags: ILD / DPLD of known origin Source Type: research

Adult Bronchiectasis in the Northern Territory of Australia: The Aboriginal and Non-aboriginal comparative study
Conclusions: There were 388 patients diagnosed to have bronchiectasis, of them 258 (66.5%) were Aboriginal Australians. Aboriginal patients were on an average 11 years younger, have higher rates of self-reported alcohol consumption(p
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Mehra, S., Chor, L., Campbell, S., Heraganahally, S. Tags: Respiratory infections Source Type: research

The use of combined endoscopy in a UK paediatric aerodigestive program
Conclusion: In our experience combining endoscopic procedures after an MDT discussion can identify help clarify and identify multiple co-existing pathologies without patients having to undergo multiple general anaesthetics. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Mussell, G., Wall, G., Thevasagayam, R., Campbell, D., Kansra, S. Tags: Paediatric bronchology Source Type: research

Effect of continuous positive airway pressure on gastroesophageal reflux in patients with  obstructive sleep apnea: a meta-analysis.
In this study, we utilized meta-analysis to investigate whether or not CPAP treatment reduces the incidence of reflux. METHODS: Two independent reviewers obtained the data sources from the database of PubMed, Elsevier, Cochrane library, and CNKI using search terms, and then filtered the target articles based on the inclusion and exclusion criteria. RevMan (version 5.3) and STATA (version 12.0) were used for data synthesis. The effect of CPAP treatment on GERD was studied by calculating the weighted mean difference (WMD) and standard deviation (SD) before and after CPAP treatment. RESULTS: Ten studies in...
Source: Sleep and Breathing - October 28, 2020 Category: Sleep Medicine Authors: Li C, Wu ZH, Pan XL, Yuan K Tags: Sleep Breath Source Type: research

Gastro-esophageal reflux disease: Key messages for clinicians.
Authors: Saracco M, Savarino V, Bodini G, Saracco GM, Pellicano R Abstract Gastroesophageal reflux disease (GERD) is a chronic common disorder for which patients often refer to specialists. In the last decades, numerous studies helped to clarify the pathophysiology and the natural history of this disease. Currently, in the clinical setting, GERD is defined by the presence of symptoms that, when endoscopic investigation is required, permit to distinguish between cases with or without associated esophageal mucosal injuries. These conditions are called erosive reflux disease and non-erosive reflux disease (NERD), resp...
Source: Minerva Gastroenterologica e Dietologica - October 27, 2020 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Do Volume of Injection and Learning Curve Influence the Results of Endoscopic Correction of Vesicoureteric Reflux Using Dextranomer/Hyaluronic Acid? A Single Surgeon Experience
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - October 27, 2020 Category: Surgery Authors: VVS Chandrasekharam Source Type: research

pH Impedance Parameters Associated with Improvement in GERD Health-Related Quality of Life Following Anti-reflux Surgery
ConclusionsOf the four pH impedance parameters that were investigated, a normal preoperative acid exposure time was associated with greater improvement in quality of life after anti-reflux surgery. Further investigation into the critical parameters on preoperative pH impedance testing using a multi-institutional cohort is warranted. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - October 27, 2020 Category: Surgery Source Type: research

Do Volume of Injection and Learning Curve Influence the Results of Endoscopic Correction of Vesicoureteric Reflux Using Dextranomer/Hyaluronic Acid? A Single Surgeon Experience
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic and Advanced Surgical Techniques)
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - October 27, 2020 Category: Surgery Authors: VVS Chandrasekharam Source Type: research

Linked color imaging improves visibility of reflux esophagitis
With more prevalent gastroesophageal reflux disease comes increased cases of Barrett's esophagus and esophageal adenocarcinoma. Image-enhanced endoscopy using linked-color imaging (LCI) differentiates between ... (Source: BMC Gastroenterology)
Source: BMC Gastroenterology - October 27, 2020 Category: Gastroenterology Authors: Tsutomu Takeda, Daisuke Asaoka, Daiki Abe, Maiko Suzuki, Yuta Nakagawa, Hitoshi Sasaki, Yoshihiro Inami, Muneo Ikemura, Hisanori Utsunomiya, Shotaro Oki, Nobuyuki Suzuki, Atsushi Ikeda, Noboru Yatagai, Hiroyuki Komori, Yoichi Akazawa, Kohei Matsumoto & he Tags: Research article Source Type: research

Reflex Gastroesophageal Disorders and Functional Dyspepsia: Potential Confounding Variables for the Progression of Chronic Periodontitis: A Clinical Study
Conclusion: GERD was linked to incremental incidences of chronic periodontitis and was established as an independent risk ‑raising factor. (Source: International Journal of Preventive Medicine)
Source: International Journal of Preventive Medicine - October 25, 2020 Category: International Medicine & Public Health Source Type: research

Does Combined Multichannel Intraluminal Impedance and pH (MII-pH) Testing Improve Clinical Outcomes in Children With Gastroesophageal Reflux Disease?
Objectives: The aim of the study was to investigate the role of combined multichannel intraluminal impedance and pH (MII-pH) testing in clinical management of children with gastroesophageal reflux disease (GERD) by exploring the impact of treatment changes made based on MII-pH testing results on symptoms and quality of life outcomes. Methods: All patients ( (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Association between gastroesophageal reflux disease and depression disorder: A protocol for systematic review and meta-analysis
Conclusions: The results of this study will provide helpful evidence to explore the association between GERD and DD. Registration number: INPLASY202090026. (Source: Medicine)
Source: Medicine - October 23, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Magnetic sphincter augmentation at the time of bariatric surgery: an analysis of the MBSAQIP
Magnetic sphincter augmentation (MSA) has gained popularity as a treatment for gastroesophageal reflux disease. The role of MSA in treating GERD in metabolic and bariatric surgery (MBS) patients at the time of primary MBS is unknown. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 23, 2020 Category: Surgery Authors: Benjamin Clapp, Christopher Dodoo, Brittany Harper, Jisoo Kim, Christian Castro, Marah Hamadan, Sam Grasso, Brian Davis Tags: Original articles Source Type: research

Acid-suppressive agents and survival outcomes in patients with cancer: a systematic review and meta-analysis
ConclusionsMeta-analysis showed that ASAs significantly associated with an increased mortality risk in lung cancer patients treated TKIs, but not in patients with esophageal/gastric, colorectal, or kidney cancer. Until further studies confirm these results, caution should be used when administering ASAs and TKIs to patients with lung cancer. (Source: International Journal of Clinical Oncology)
Source: International Journal of Clinical Oncology - October 22, 2020 Category: Cancer & Oncology Source Type: research

Muscle Tension Dysphagia: Contributing Factors and Treatment Efficacy.
CONCLUSION: The study results suggest an association between laryngeal muscle tension and these patients' dysphagia symptoms regardless of associated conditions. Speech-language pathology intervention showed high treatment efficacy. LEVEL OF EVIDENCE: 2c- Outcomes research. PMID: 33090008 [PubMed - as supplied by publisher] (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - October 22, 2020 Category: ENT & OMF Authors: Kang CH, Zhang N, Lott DG Tags: Ann Otol Rhinol Laryngol Source Type: research

Endoscopic Screening for Barrett ’s Esophagus and Esophageal Adenocarcinoma
Barrett ’s esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC), a cancer with increasing incidence and poor survival. Risk of EAC in patients with BE is higher compared with the general population. Endoscopic screening for BE is performed to identify patients earlier in the metap lasia-dysplasia-carcinoma sequence from BE to EAC to enable eradication therapy. BE screening should be considered in individuals with multiple risk factors for BE and EAC. Challenges to BE screening include the absence of a cost-effective, widely applicable minimally invasive screening tool, gastro esophageal reflu...
Source: Gastrointestinal Endoscopy Clinics of North America - October 21, 2020 Category: Gastroenterology Authors: Amrit K. Kamboj, David A. Katzka, Prasad G. Iyer Source Type: research

Epidemiology of Barrett's Esophagus and Esophageal Adenocarcinoma
In the United States, the incidence of esophageal adenocarcinoma increased markedly since the 1970s with a recent stabilization. Despite evolving screening and surveillance strategies to diagnose, risk triage, and intervene in Barrett ’s esophagus patients to prevent esophageal adenocarcinoma, most cases present with advanced disease and poor resultant survival. Epidemiologic studies have identified the main risk factors for these conditions, including increasing age, male sex, white race, gastroesophageal reflux disease, abdom inal obesity, cigarette smoking, and lack of infection with Helicobacter pylori. This revi...
Source: Gastrointestinal Endoscopy Clinics of North America - October 21, 2020 Category: Gastroenterology Authors: Michael B. Cook, Aaron P. Thrift Source Type: research