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Proton Pump Inhibitors and Kidney Disease: Fact or Fiction?
Am J Nephrol. 2024 Apr 6. doi: 10.1159/000538755. Online ahead of print.ABSTRACTBACKGROUND: Proton pump inhibitors (PPI) are commonly prescribed medications for dyspepsia and gastroesophageal reflux. There are concerns about their use in the development of chronic kidney disease (CKD).SUMMARY: The available published literature fails to support an association with PPI and the development of CKD. Placebo-controlled trials demonstrate no difference on the incidence of CKD between placebo and PPI. If one examines the data according to the Bradford Hill perspective incorporating temporal relationship, strength of association, ...
Source: American Journal of Nephrology - April 7, 2024 Category: Urology & Nephrology Authors: Matthew Ryan Weir Source Type: research

Prediction, prevention and management of gastroesophageal reflux after per-oral endoscopic myotomy: An update
World J Gastroenterol. 2024 Mar 7;30(9):1096-1107. doi: 10.3748/wjg.v30.i9.1096.ABSTRACTAchalasia cardia, the most prevalent primary esophageal motility disorder, is predominantly characterized by symptoms of dysphagia and regurgitation. The principal therapeutic approaches for achalasia encompass pneumatic dilatation (PD), Heller's myotomy, and the more recent per-oral endoscopic myotomy (POEM). POEM has been substantiated as a safe and efficacious modality for the management of achalasia. Although POEM demonstrates superior efficacy compared to PD and an efficacy parallel to Heller's myotomy, the incidence of gastroesoph...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Zaheer Nabi Pradev Inavolu Nageshwar Reddy Duvvuru Source Type: research

Prediction, prevention and management of gastroesophageal reflux after per-oral endoscopic myotomy: An update
World J Gastroenterol. 2024 Mar 7;30(9):1096-1107. doi: 10.3748/wjg.v30.i9.1096.ABSTRACTAchalasia cardia, the most prevalent primary esophageal motility disorder, is predominantly characterized by symptoms of dysphagia and regurgitation. The principal therapeutic approaches for achalasia encompass pneumatic dilatation (PD), Heller's myotomy, and the more recent per-oral endoscopic myotomy (POEM). POEM has been substantiated as a safe and efficacious modality for the management of achalasia. Although POEM demonstrates superior efficacy compared to PD and an efficacy parallel to Heller's myotomy, the incidence of gastroesoph...
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Zaheer Nabi Pradev Inavolu Nageshwar Reddy Duvvuru Source Type: research