Neuroendocrine cell hyperplasia of infancy: An unusual cause of unresolving tachypnea in infancy
A 6-month-old full-term male patient was born uneventfully through vaginal delivery. At the age of 3 months, he began experiencing unresolving dry cough and poor feeding. During respiratory auscultation, tachypnea without adventitious breath sounds was noted. Chest radiograph (CxR) based from the latest admission revealed ground-glass opacity (GGO) and hyperinflation in bilateral lung fields (Supplement Fig.). Meanwhile, echocardiogram showed a patent foramen ovale, while esophagogram was negative for tracheoesophageal fistula or gastroesophageal reflux. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 6, 2019 Category: Perinatology & Neonatology Authors: Sui-Ling Liao, Shen-Hao Lai Tags: Letter to the Editor Source Type: research

Short-Term and Long-Term Outcomes of Paraesophageal Hernia Repair
The assessment of outcome after paraesophageal repair is difficult and complex. There is a wide range of reported outcomes that are not consistently defined. The focus of this article is on short-term ( ≤5 years) and long-term (>5  year) outcomes after laparoscopic paraesophageal repair and reviews key patient-reported outcomes (gastroesophageal reflux disease [GERD]–related and non–GERD-related symptoms), radiologic recurrence, additional therapy, and objective measurements. Overall, patients reported an excellent impro vement in their quality of life after repair that remains durable. Recurren...
Source: Thoracic Surgery Clinics - September 6, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Anne-Sophie Laliberte, Brian E. Louie Source Type: research

Management of Paraesophageal Hernia in the Morbidly Obese Patient
Gastroesophageal reflux disease (GERD) is common in the morbidly obese population, and hiatal hernias are encountered in 20% to 52% of patients. Primary surgical repair of hiatal hernias, in particular the paraesophageal type, is associated with a higher recurrence rate in obese patients. Concomitant weight loss surgery may be advisable. Combined sleeve gastrectomy and paraesophageal hiatal hernia repair is feasible but can induce or worsen preexisting GERD. A Roux-en-Y gastric bypass offers advantages of more pronounced excess weight loss and better symptom control, albeit with a potentially higher rate of morbidity compa...
Source: Thoracic Surgery Clinics - September 6, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Charles T. Bakhos, Shrey P. Patel, Roman V. Petrov, Abbas E. Abbas Source Type: research

Non-canonical Wnt Signaling through Ryk Regulates the Generation of Somatostatin- and Parvalbumin-Expressing Cortical Interneurons
Publication date: 4 September 2019Source: Neuron, Volume 103, Issue 5Author(s): Melissa G. McKenzie, Lucy V. Cobbs, Patrick D. Dummer, Timothy J. Petros, Michael M. Halford, Steven A. Stacker, Yimin Zou, Gord J. Fishell, Edmund AuSummaryGABAergic interneurons have many important functions in cortical circuitry, a reflection of their cell diversity. The developmental origins of this diversity are poorly understood. Here, we identify rostral-caudal regionality in Wnt exposure within the interneuron progenitor zone delineating the specification of the two main interneuron subclasses. Caudally situated medial ganglionic eminen...
Source: Neuron - September 5, 2019 Category: Neuroscience Source Type: research

Effect of Acid Suppression on Peripheral T-Lymphocyte Subsets and Immunohistochemical Esophageal Mucosal Changes in Patients With Gastroesophageal Reflux Disease
Background and Aims: Gastroesophageal reflux disease (GERD) is a common prevalent disease. We aimed to assess the dynamic changes in the peripheral T lymphocytes and lymphocytes infiltrating the esophageal mucosa after treatment with proton-pump inhibitor (PPI) in patients with GERD. Patients and Methods: A total of 200 patients who presented with upper GIT symptoms were included in this prospective study. All patients were subjected to full history taking, clinical examination, and complete blood count. Upper endoscopy was performed to detect the grade of GERD, followed by 4 quadrant biopsies before and 1 month after...
Source: Journal of Clinical Gastroenterology - September 5, 2019 Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research

Impact Of Fundoplication For Gastroesophageal Reflux In The Outcome Of Benign Tracheal Stenosis
This study focuses on the impact of anti-reflux surgery in the outcome of tracheal stenosis. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - September 5, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Edno Tales Bianchi, Paulo Francisco Guerreiro Cardoso, Helio Minamoto, Benoit Jacques Bibas, Michele Salati, Paulo Manuel Pego-Fernandes Source Type: research

[TECHNIQUES] Use of Bioelectronics in the Gastrointestinal Tract
Gastrointestinal (GI) motility disorders are major contributing factors to functional GI diseases that account for>40% of patients seen in gastroenterology clinics and affect>20% of the general population. The autonomic and enteric nervous systems and the muscles within the luminal GI tract have key roles in motility. In health, this complex integrated system works seamlessly to transport liquid, solid, and gas through the GI tract. However, major and minor motility disorders occur when these systems fail. Common functional GI motility disorders include dysphagia, gastroesophageal reflux disease, functional dyspepsia...
Source: Cold Spring Harbor perspectives in medicine - September 3, 2019 Category: Research Authors: Miller, L., Farajidavar, A., Vegesna, A. Tags: Bioelectronic Medicine TECHNIQUES Source Type: research

Per-oral endoscopic myotomy and gastroesophageal reflux: Where do we stand after a decade of “POETRY”?
AbstractPer-oral endoscopic myotomy (POEM) was introduced nearly a decade ago. Since then, the literature on its safety and efficacy has been ever increasing. Initial studies focused solely on the feasibility and efficacy of this procedure in patients with idiopathic achalasia. Subsequent studies analyzed the incidence of gastroesophageal reflux disease (GERD) in addition to the efficacy of POEM. These studies depict a high incidence of GERD after POEM. However, vast majority of these studies lacked a comprehensive evaluation of GERD after POEM. Consequently, it is difficult to provide a true estimate of the incidence of G...
Source: Indian Journal of Gastroenterology - September 2, 2019 Category: Gastroenterology Source Type: research

Barrett Esophagus
Barrett esophagus is a metaplastic change in the lining of the distal esophageal epithelium, characterized by replacement of the normal squamous epithelium by specialized intestinal metaplasia. The presence of Barrett esophagus increases the risk of esophageal adenocarcinoma several-fold. Esophageal adenocarcinoma is a malignancy with rapidly rising incidence and persistently poor outcomes when diagnosed after the onset of symptoms. Risk factors for Barrett esophagus include chronic gastroesophageal reflux, central obesity, white race, male gender, older age, smoking, and a family history of Barrett esophagus or esophageal...
Source: Mayo Clinic Proceedings - September 1, 2019 Category: Internal Medicine Authors: Prasad G. Iyer, Vivek Kaul Tags: Thematic review on gastroenterological diseases Source Type: research

[A Difficult-to-Treat Asthma Bronchiale Is Not Necessarily a Severe Asthma].
Abstract A Difficult-to-Treat Asthma Bronchiale Is Not Necessarily a Severe Asthma Abstract. New biologicals offer the opportunity for treatment of 'difficult-to-treat' asthma. Before prescribing these medications, each 'difficult-to-treat' asthma bronchiale has to be checked for factors aggravating asthma control (e.g. insufficient inhalation technique and adherence, persistent allergen exposure) and asthma-related comorbidities (e.g. rhinosinusitis, gastro-esophageal reflux disease or obstructive sleep apnea) rendering the asthma 'controlled'. Asthma phenotyping s essential for the understanding of different tre...
Source: Praxis - September 1, 2019 Category: General Medicine Authors: Nussbaumer-Ochsner Y Tags: Praxis (Bern 1994) Source Type: research

[The Mysterious Cough - a Case-Based Proposal of Differential Diagnosis].
Abstract The Mysterious Cough - a Case-Based Proposal of Differential Diagnosis Abstract. Cough is a frequent complaint in the general practice. Avoidance of overdiagnosis and underdiagnosis is essential. In case of acute cough or subacute (8 week duration) and normal baseline examination and after cessation of smoking and medication with ACE-I, cough-variant asthma, gastro-esophageal reflux disease and upper airway cough syndrome are the main causes and should be assessed and empirically treated in a systematic manner. PMID: 31480953 [PubMed - in process] (Source: Praxis)
Source: Praxis - September 1, 2019 Category: General Medicine Authors: Wieser S Tags: Praxis (Bern 1994) Source Type: research

Can Chinese T2D patients with BMI 20-32.5 kg/m2 benefit from loop  duodenojejunal bypass with sleeve gastrectomy?
This study investigated the therapeutic outcomes of LDJB-SG and predictors of type 2 diabetes (T2D) remission in Chinese patients with a body mass index (BMI) of 20 to 32.5 kg/m2. SETTING: A university hospital. METHODS: This retrospective study included 28 T2D patients with a BMI of 20 to 32.5 kg/m2 who underwent LDJB-SG. T2DM remission, weight loss, postoperative nutrition status, and complications at 1- and 3-year follow-up were assessed. Remission of T2DM was defined as a fasting blood glucose
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - September 1, 2019 Category: Surgery Authors: Lin S, Yang N, Guan W, Liang H Tags: Surg Obes Relat Dis Source Type: research

Characterization of Gender-Related Disparity in Gastroesophageal Reflux Disease: Surgical Perspective from a Rural High-Volume Antireflux Program.
PMID: 31638552 [PubMed - in process] (Source: The American Surgeon)
Source: The American Surgeon - September 1, 2019 Category: Surgery Authors: Fanous M, Jaehne A, Williams S, Lambert A Tags: Am Surg Source Type: research

Laparoendoscopic Single-Site (LESS) versus Robotic "Redo" Hiatal Hernia Repair with Fundoplication: Which Approach Is Better?
This study was undertaken to evaluate the robotic approach versus laparoendoscopic single-site (LESS) approach for redo fundoplications. With an Institutional Review Board approval, 64 patients undergoing LESS (n = 32) or robotic (n = 32) redo antireflux operations were prospectively followed up. Data are presented as median (mean + SD). For LESS versus robotic redo operations, the operative duration was 145 (143 ± 33.5) versus 196 (208 ± 76.7) minutes (P
Source: The American Surgeon - September 1, 2019 Category: Surgery Authors: Giovannetti A, Craigg D, Castro M, Ross S, Sucandy I, Rosemurgy A Tags: Am Surg Source Type: research

Quality of Life before and after Sleeve Gastrectomy in Lebanese Population.
Authors: Alkassis M, Haddad FG, Gharios J, Noun R, Chakhtoura G Abstract Introduction: Obesity is increasing worldwide and in Lebanon with a negative impact on the quality of life. The primary objective of this study is to measure the quality of life in obese subjects before and after bariatric surgery, depending on age, sex, and degree of weight loss. A secondary objective is to determine the impact of bariatric surgery on comorbidities associated with obesity. Materials and methods: Patients undergoing laparoscopic sleeve gastrectomy for BMI ≥ 30 kg/m2 between August 2016 and April 201...
Source: Journal of Obesity - August 31, 2019 Category: Eating Disorders & Weight Management Tags: J Obes Source Type: research

Etiologies associated with chronic cough and its clinical characteristics in school-age children.
Conclusions: The common etiologies of chronic cough in school-age children were UACS, CVA, and PB, while EB and GERD were rare. PMID: 31463138 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - August 31, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Mid-Term Outcome of Mandibular Distraction Osteogenesis in Pierre Robin Sequence
The aim of the present study was to present a single center's experience with mandibular distraction osteogenesis (MDO) in Pierre Robin sequence (PRS) patients. A retrospective chart review was performed to identify patients with PRS that underwent MDO at our institution from 2003 to 2012. Inclusion criteria were as follows: All pediatric patients with PRS who were not adequately managed with conservative therapy;Those who underwent MDO with internal mandibular distractors;Not previous treatment elsewhere andPatients were followed for ≥3 years. Evaluation included demographic information, postoperative complications, ...
Source: Journal of Craniofacial Surgery - August 30, 2019 Category: Surgery Tags: Original Articles Source Type: research

Z-line alterations and gastroesophageal reflux: an endoscopic population-based prospective cohort study.
Conclusions: In a general community, the only endoscopic alteration to the Z-line definitely linked to longstanding GER symptoms was the presence of obvious tongues of metaplastic columnar epithelium (ZAP II/III). PMID: 31453726 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 29, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Modified Sleeve Gastrectomy Combined with Laparoscopic Rossetti Fundoplication and Vascularization Assessment with Indocyanine Green
ConclusionThe modified sleeve gastrectomy combined with laparoscopic Rossetti fundoplication seems to be a safe, effective procedure and a suitable alternative to gastric bypass in obese patients with GERD. (Source: Obesity Surgery)
Source: Obesity Surgery - August 29, 2019 Category: Surgery Source Type: research

Exposure to Bile Leads to the Emergence of Adaptive Signaling Variants in the Opportunistic Pathogen Pseudomonas aeruginosa
The chronic colonisation of the respiratory tract by the opportunistic pathogen Pseudomonas aeruginosa is the primary cause of morbidity and mortality in Cystic Fibrosis (CF) patients. P. aeruginosa has been shown to undergo extensive genomic adaptation facilitating its persistence within the CF lung allowing it to evade the host immune response and outcompete co-colonising residents of the lung microbiota. However, whilst several studies have described the various mutations that frequently arise in clinical isolates of P. aeruginosa, the environmental factors governing the emergence of these genetic variants is less well ...
Source: Frontiers in Microbiology - August 29, 2019 Category: Microbiology Source Type: research

New optically active camphor-derived cyclopalladated complexes with an asymmetric carbon bonded to the metal
Publication date: Available online 27 August 2019Source: Journal of Organometallic ChemistryAuthor(s): Purna Chandra Rao Vasireddy, Gerard C. Dickmu, Angel Ugrinov, Irina P. SmoliakovaAbstractN,N-Dimethylhydrazone of D-camphor 1 was obtained as the single E isomer in 80% yield by treating the enantiopure ketone with N,N-dimethylhydrazine in the presence of an equimolar amount of p-toluenesulfonic acid in ethanol. Direct cyclopalladation of hydrazone 1 was accomplished at the C(3)H2 group using [Pd(MeCN)2Cl2] and NaOAc in MeCN at the reflux temperature. The product of the reaction, dinuclear cyclopalladated complex 2, was i...
Source: Journal of Organometallic Chemistry - August 28, 2019 Category: Chemistry Source Type: research

Is sleeve gastrectomy over-criticized? a single center indian experience with 5 years follow up results
Bariatric surgery has seen a sharp rise in numbers worldwide in the last decade. Being a popular procedure, sleeve gastrectomy(SG) has been widely studied over the years for its efficacy, potential of weight regain, metabolic impact and de novo Gastro-esophageal reflux disease (GERD). (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - August 28, 2019 Category: Surgery Authors: Amrit Manik Nasta, Sharmila Vyas, Madhu Goel, Ramen Goel Tags: Original articles Source Type: research

Is sleeve gastrectomy overcriticized? A single-center Indian experience with 5-year follow-up results
Bariatric surgery has seen a sharp rise in numbers worldwide in the last decade. Being a popular procedure, sleeve gastrectomy (SG) has been widely studied over the years for its efficacy, potential for weight regain, metabolic impact, and de novo gastroesophageal reflux disease (GERD). (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - August 28, 2019 Category: Surgery Authors: Amrit Manik Nasta, Sharmila Vyas, Madhu Goel, Ramen Goel Tags: Original article Source Type: research

Eosinophilic esophagitis: Current concepts in diagnosis and treatment.
-Mindiola A Abstract Eosinophilic esophagitis is an immune-allergic pathology of multifactorial etiology (genetic and environmental) that affects both pediatric and adult patients. Its symptoms, which include heartburn, regurgitation, and esophageal stenosis (with dysphagia being more frequent in eosinophilic esophagitis in young adults and children), are similar to those of gastroesophageal reflux disease, causing delays in diagnosis and treatment. Although endoscopic findings such as furrows, esophageal mucosa trachealization, and whitish exudates may suggest its presence, this diagnosis should be confirmed hist...
Source: World Journal of Gastroenterology : WJG - August 28, 2019 Category: Gastroenterology Authors: Gómez-Aldana A, Jaramillo-Santos M, Delgado A, Jaramillo C, Lúquez-Mindiola A Tags: World J Gastroenterol Source Type: research

Internal hernia following laparoscopic roux-en-y gastric by-pass: indicative factors for early repair
CONCLUSION: The presence of recurrent abdominal pain is one of the main indicators for the diagnosis of IH after LRYGB. Patients operated at an early stage, even with negative imaging tests for this disease, benefited from rapid and simple procedures without major complications.RESUMO CONTEXTO: H érnia interna (HI) após bypass gástrico em Y de Roux laparoscópico (BGYRL) é uma complicação importante que desafia o cirurgião devido à sua apresentação inespecífica e necessidade de reparo precoce. Um diagnóstico e intervençã...
Source: Arquivos de Gastroenterologia - August 27, 2019 Category: Gastroenterology Source Type: research

Historical perspective of gastroesophageal reflux disease clinical treatment
CONCLUSION: Recognizing the historical evolution of GERD management can help care providers to better understand therapeutic options for their patients, as well as focus on unmet needs that deserve further attention. PPIs are still the first choice therapy, with good evidence in favor of their efficacy, despite some safety concerns. However, as with any medical intervention, it is recommended to prescribe PPIs for patients with clear indication, using adequate dosing and monitoring for adverse events.RESUMO CONTEXTO: A doen ça do refluxo gastroesofágico (DRGE) é uma das doenças gastrointestinais...
Source: Arquivos de Gastroenterologia - August 27, 2019 Category: Gastroenterology Source Type: research

Reaction to articles on high resolution manometry, the length of the lower esophageal sphincter and the diagnosis of gastroesophageal reflux disease
CONCLUSION: Recognizing the historical evolution of GERD management can help care providers to better understand therapeutic options for their patients, as well as focus on unmet needs that deserve further attention. PPIs are still the first choice therapy, with good evidence in favor of their efficacy, despite some safety concerns. However, as with any medical intervention, it is recommended to prescribe PPIs for patients with clear indication, using adequate dosing and monitoring for adverse events.RESUMO CONTEXTO: A doen ça do refluxo gastroesofágico (DRGE) é uma das doenças gastrointestinais...
Source: Arquivos de Gastroenterologia - August 27, 2019 Category: Gastroenterology Source Type: research

In defense of four decades of esophageal function tests. reply to reaction to articles on high resolution manometry, the length of the lower esophageal sphincter and the diagnosis of gastroesophageal reflux disease
CONCLUSION: Recognizing the historical evolution of GERD management can help care providers to better understand therapeutic options for their patients, as well as focus on unmet needs that deserve further attention. PPIs are still the first choice therapy, with good evidence in favor of their efficacy, despite some safety concerns. However, as with any medical intervention, it is recommended to prescribe PPIs for patients with clear indication, using adequate dosing and monitoring for adverse events.RESUMO CONTEXTO: A doen ça do refluxo gastroesofágico (DRGE) é uma das doenças gastrointestinais...
Source: Arquivos de Gastroenterologia - August 27, 2019 Category: Gastroenterology Source Type: research

[Ineffective esophageal motility].
Abstract Ineffective esophageal motility is the most frequent esophageal motility disorder. It is currently defined by 50% or more ineffective esophageal contractions and a normal lower esophageal sphincter relaxation on high-resolution esophageal manometry. Although reported in patients without symptoms, it is typically associated with gastro-esophageal reflux disease, and might be a consequence of the reflux. Ineffective esophageal motility can account for a certain degree of dysphagia, and is associated with a more severe gastroesophageal reflux. Todate, no specific endoscopic or pharmacologic treatment is avai...
Source: Presse Medicale - August 27, 2019 Category: General Medicine Authors: Leandri C, Guillaumot MA, Dohan A, Leconte M, Coriat R, Chaussade S, Barret M Tags: Presse Med Source Type: research

Risk factors predisposing to cardia gastric adenocarcinoma: Insights and new perspectives
The etiology of adenocarcinoma of the cardia and the gastroesophageal junction (GEJ) is not known and is doubted. It is thought that cardia gastric adenocarcinoma (CGA) is distinct from adenocarcinomas located in the esophagus or distal stomach, both epidemiologically and biologically. Moreover, CGA is often identified in the advanced stage having a poor prognosis. In this paper, we would like to ascertain the possible role of GC family history, lifestyle, demographics, gastroesophageal reflux disease,Helicobacter pylori infection, and multiple genetic and epigenetic risk factors as well as several predisposing conditions ...
Source: Cancer Medicine - August 25, 2019 Category: Cancer & Oncology Authors: Esmat Abdi, Saeid Latifi ‐Navid, Saber Zahri, Abbas Yazdanbod, Farhad Pourfarzi Tags: REVIEW Source Type: research

Issue Highlights
Dysphagia is one of the most common postoperative symptoms reported by patients following antireflux surgery. A recent paper in Clinical Gastroenterology and Hepatology provided a comprehensive overview of recent advances in the management of esophageal motility disorders in general.1 In this issue, Hasak and colleagues2 report outcomes of adults who developed dysphagia following antireflux surgery for treatment of gastroesophageal reflux disease. Of 157 patients, 64.3% reported postoperative dysphagia; about half reported clinically significant dysphagia, defined as a score ≥ 2 on a 5-point Likert scale. (Source: Clini...
Source: Clinical Gastroenterology and Hepatology - August 23, 2019 Category: Gastroenterology Authors: Ziad Gellad Tags: Issue highlights Source Type: research

Can the Reflux Finding Score and Reflux Symptom Index Be Used to Evaluate the Severity of Esophagitis in Children?
Laryngopharyngeal reflux (LPR), a growing issue in ear, nose, and throat (ENT) and pediatric medicine, is the backflow of stomach contents into the laryngopharynx. Patients present with frequent upper and/or lower respiratory tract infections and coughs, associated with acid- and pepsin-mediated injury to the mucosae of the larynx and pharynx. LPR is associated with rhinosinusitis, laryngitis, pneumonia, and asthma. Children with LPR often fail to exhibit classic gastroesophageal reflux disease symptoms, or such symptoms may be intermittent. (Source: Journal of Voice)
Source: Journal of Voice - August 23, 2019 Category: ENT & OMF Authors: Meltem Korkut Ugras, Muzeyyen Dogan, D. Yavuz Selim Pata, Ferda Ozkan Source Type: research

The influence of gastroesophageal reflux symptoms on patient satisfaction after sleeve gastrectomy
Sleeve gastrectomy has become the most common procedure performed for weight loss. But emerging data indicate that this procedure can result in lifestyle-limiting gastroesophageal reflux disease. The influence of these gastroesophageal reflux disease symptoms on patient satisfaction with the procedure has not been explored. (Source: Surgery)
Source: Surgery - August 22, 2019 Category: Surgery Authors: Inga A. Van Wieren, Jyothi R. Thumma, Nabeel R. Obeid, Oliver A. Varban, Justin B. Dimick Source Type: research

The Case | An 82-year-old male with worsening kidney function
An 82-year-old male, with a history of bowel cancer with partial colectomy, gastroesophageal reflux disease, remote partial gastrectomy for peptic ulcer disease, and no documented prior kidney disease, presents with several months of fatigue and subacute decline in kidney function. He had no history of diabetes, hypertension, kidney stones, or prior urinary tract infections. He denied use of nonsteroidal anti-inflammatory agents, herbal medications, and recent antibiotics. There was no family history of renal disease. (Source: Kidney International)
Source: Kidney International - August 21, 2019 Category: Urology & Nephrology Authors: George L. Worthen, Laurette Geldenhuys, Karthik K. Tennankore Tags: Make Your Diagnosis Source Type: research

Total gastrectomy in systemic scleroderma when anti-reflux surgery is not viable: a case report
DiscussionWe suggest an open gastrectomy with roux-en-Y anastomosis as an alternative to the Nissen fundoplication for patients with connective tissue disease that develop terminal pulmonary consequences and require a lung transplant. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - August 20, 2019 Category: Surgery Source Type: research

The outcomes of fundoplication and gastrostomy in neurologically impaired children in a tertiary care hospital in Saudi Arabia.
Conclusions: Fundoplication with GT is effective in reducing hospital admissions and emergency department visits from GER and seizures in NI children. Because of high mortality within a year of fundoplication and GT in DNR children, anti-reflux medications with GT might be an alternative. PMID: 31423518 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - August 20, 2019 Category: Middle East Health Tags: Saudi Med J Source Type: research

Correlates of gastroenterology health-services utilization among patients with gastroesophageal reflux disease: a large database analysis
ConclusionsPatient and physician ’s characteristics were related to high utilization of gastroenterology services among GERD patients. The associations with age and country of birth might reflect more severe disease. The regional differences warrant further research and interventions at the district level. Training in gastroenter ology of primary care physicians without a board certification is warranted. (Source: Israel Journal of Health Policy Research)
Source: Israel Journal of Health Policy Research - August 20, 2019 Category: International Medicine & Public Health Source Type: research

Higher Esophageal Symptom Burden in Obese Subjects Results From Increased Esophageal Acid Exposure and Not From Dysmotility
We examined the relationships among symptom burden, EMD, acid exposure time (AET), symptom association probability, and body mass index (BMI). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 20, 2019 Category: Gastroenterology Authors: Benjamin D. Rogers, Amit Patel, Dan Wang, Gregory S. Sayuk, C. Prakash Gyawali Source Type: research

Laparoscopic Hiatal Hernia Repair Followed by Transoral Incisionless Fundoplication With EsophyX Device (HH + TIF): Efficacy and Safety in Two Community Hospitals.
This study examined the safety and efficacy when repairing defects in 2 anatomical structures (hiatus and lower esophageal sphincter) in a concomitant set of procedures in patients with hiatal hernias between 2 and 5 cm. Methods. Prospective data were collected from 99 patients who underwent hiatal hernia repair followed immediately by the TIF procedure (HH + -TIF). GERD-HRQL (Health-Related Quality of Life), RSI (Reflux Symptom Index), and GERSS (Gastroesophageal Reflux Symptom Score) questionnaires were administered before the procedure and mailed at 6 and 12 months. Results. Ninety-nine patients were enrolled, and all w...
Source: Surgical Innovation - August 20, 2019 Category: Surgery Authors: Janu P, Shughoury AB, Venkat K, Hurwich D, Galouzis T, Siatras J, Streeter D, Korman K, Mavrelis G, Mavrelis P Tags: Surg Innov Source Type: research

Gastro-oesophageal reflux disease symptoms and associated risk factors among medical students, Saudi Arabia
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - August 19, 2019 Category: General Medicine Tags: International Journal of General Medicine Source Type: research

Associations among gastroesophageal reflux disease, mental disorders, sleep and chronic temporomandibular disorder: a case-control study.
Abstract BACKGROUND: Temporomandibular disorders (TMDs) are a family of pain-related disorders associated with impaired function in the jaw, temporomandibular joint and muscles of mastication. Our objectives were to evaluate the association between chronic TMD and gastresophageal reflux disease (GERD) and to determine whether mental disorders or undermined sleep mediates this association. METHODS: We conducted a case-control study involving 1522 consecutive adult patients with chronic TMD and 1522 matched controls from 2 hospitals in China. All participants were aged between 18 and 70 years and were recruited...
Source: cmaj - August 19, 2019 Category: General Medicine Authors: Li Y, Fang M, Niu L, Fan Y, Liu Y, Long Y, Liu X, Tay FR, Chen J Tags: CMAJ Source Type: research

Gastric Acid and Pepsin Work Together in Simulated Gastric Acid Inhalation Leading to Pulmonary Fibrosis in Rats.
CONCLUSIONS The study demonstrates that aspiration of gastric contents can cause pulmonary fibrosis, and mixed aspiration of pepsin and gastric fluid can accelerate this process. This study provides strong evidence in support of a potential association between human GERD and IPF. PMID: 31419218 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Managing End-Stage Renal Disease: An Alphabetized Mnemonic Strategy
The objective of this article is to provide a structured and applicable approach to managing ESRD that is up-to-date and evidence based. To achieve this objective, we created an alphabetized mnemonic and synthesized our discussion to address Anemia, Bone health, Cardiovascular issues, vitamin D deficiency, Electrolytes imbalances, Fluid overload, and Gastroesophageal reflux in patients with ESRD. (Source: The Journal for Nurse Practitioners)
Source: The Journal for Nurse Practitioners - August 16, 2019 Category: Nursing Authors: Mohamed Toufic El Hussein, Lauren Kilfoil Tags: Feature Article Source Type: research

Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran.
Authors: Mohammadifard M, Saremi Z, Rastgoo M, Akbari E Abstract There is evidence that infection by H. pylori can have a critical proportion in the development of hepatocyte injury and both noncancerous and malignant liver conditions including non-alcoholic fatty liver disease (NAFLD). This is attributed to several mechanisms, the most important one being the toxic products of the bacterium H. pylori and oxidative injury for hepatocytes which promotes hepatic injury. The present research was aimed at determining the association between H. pylori infection and the prevalence of NAFLD in Birjand, Iran. Two groups we...
Source: Journal of Medicine and Life - August 15, 2019 Category: General Medicine Tags: J Med Life Source Type: research

[Pharyngeal acid load and different functional endoscopy findings].
Authors: Michel F, Dannesberger R, Stroh T, Fritsche R, Ahrens P Abstract The findings of functional endoscopy (upper esophageal sphincter insufficiency, cardia insufficiency, esophagitis, gastric heterotopia, axial sliding hernia, and visible aerosols) can be traced back to pharyngeal acid exposure by oropharyngeal pH measurement. Significantly increased pharyngeal acid loads are seen in gastric heterotopy and axial sliding hernia. For all measured statistics, the pharyngeal acid load is in the pathological or even very pathological range. The value of functional endoscopy in the context of laryngopharyngeal reflu...
Source: HNO - August 14, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Long-Term Results After Laparoscopic Sleeve Gastrectomy with Concomitant Posterior Cruroplasty: 5-Year Follow-up
AbstractBackgroundHiatal hernia (HH) repair during laparoscopic sleeve gastrectomy (LSG) has been advocated to reduce the incidence of postoperative gastroesophageal reflux disease (GERD) and/or intrathoracic migration (ITM). The necessity of intraoperative repair in asymptomatic patients is still controversial. Previous, mid-term results of a prospective, comparative study evaluating posterior cruroplasty concomitant with LSG (group A 48 patients with simple vs. group B 48 reinforced with bioabsorbable mesh) confirmed the safety and effectiveness of simultaneous procedures. Present aim was to report the 60  months fo...
Source: Journal of Gastrointestinal Surgery - August 13, 2019 Category: Surgery Source Type: research

Novel insights into the Dispersed and Acid-mediated Surface Modification of the Carbon Nanofibers
Publication date: Available online 6 August 2019Source: Materials Chemistry and PhysicsAuthor(s): Kamini Turan, Prabhsharan Kaur, Dinesh Manhas, Jadab Sharma, Gaurav VermaCarbon nanofibers (CNF) are the state of art materials owing to their special morphological features. In the pristine form, they exhibit strong van der Waals interactions which keep them agglomerated. The actual potential of these nanofibers could be realized once these are unbundled. In this work, CNF have been dispersed with Triton X-100 during ultrasonication, and further functionalized using 3:1 mixture of H2SO4 and HNO3 via reflux method. The effects...
Source: Materials Chemistry and Physics - August 9, 2019 Category: Materials Science Source Type: research

Cost-utility analysis of a ‘vonoprazan-first’ strategy versus ‘esomeprazole- or rabeprazole-first’ strategy in GERD
ConclusionsVonoprazan-first strategy increased QALYs and appeared to be cost-effective for GERD patients compared with the esomeprazole- or rabeprazole-first strategies. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 8, 2019 Category: Gastroenterology Source Type: research

Clinico-radiologic Features of Lung Disease Associated with Aspiration Identified on Lung Biopsy.
CONCLUSIONS: Aspiration can occur in the absence of subjective or demonstrable swallowing difficulties and manifest a broad spectrum of clinico-radiologic presentations. PMID: 31398348 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - August 6, 2019 Category: Respiratory Medicine Authors: Ryu AJ, Navin PJ, Hu X, Yi ES, Hartman TE, Ryu JH Tags: Chest Source Type: research

Recurrent Febrile Urinary Tract Infections and Renal Scarring
In this issue of JAMA Pediatrics, Shaikh et al continue to shed light on important aspects of urinary tract infections (UTIs) in children based on data gleaned from the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) and Careful Urinary Tract Infection Evaluation (CUTIE) trials. The study by Shaikh et al addresses the likelihood of new renal scars developing after a first febrile UTI and after recurrent UTIs. Three decades ago, the pioneering group in Sweden identified a slight increase in renal scarring from the first UTI to the second and from the second to the third; only after 3 UTIs did the rat...
Source: JAMA Pediatrics - August 5, 2019 Category: Pediatrics Source Type: research