Endoscopic magnet placement into sub-adventitial tunnels for augmenting lower esophageal sphincter using submucosal endoscopy: ex vivo and in vivo study in a porcine model (with video)
This study aimed to determine if magnets could be placed endoscopically using the adventitial layer creating a sub-adventitial space near the esophagogastric junction to augment the lower esophageal sphincter using the submucosal endoscopy. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - September 24, 2018 Category: Gastroenterology Authors: Akira Dobashi, Shu-Wei Wu, Jodie L. Deters, Charles A. Miller, Mary A. Knipschield, Graham P. Cameron, Lichun Lu, Elizabeth Rajan, Christopher J. Gostout Source Type: research

Correction to: Gastroesophageal reflux disease: from heartburn to Barrett esophagus, and beyond
The author name Marco G. Patti was incorrectly published. (Source: Updates in Surgery)
Source: Updates in Surgery - September 21, 2018 Category: Surgery Source Type: research

Gastroesophageal reflux disease and its related factors among women of reproductive age: Korea Nurses ’ Health Study
Recently, the number of patients diagnosed with gastroesophageal reflux disease (GERD) has increased in Korea. Risk factors of GERD include age, sex, medication use, lack of physical exercise, increased psycho... (Source: BMC Public Health)
Source: BMC Public Health - September 21, 2018 Category: Consumer Health News Authors: Oksoo Kim, Hee Jung Jang, Sue Kim, Hea-Young Lee, Eunyoung Cho, Jung Eun Lee, Heeja Jung and Jiyoung Kim Tags: Research article Source Type: research

Current Indications for Transnasal Esophagoscopy: An American Broncho-Esophagological Association Survey.
Abstract INTRODUCTION: The aim of this study was to evaluate the current indications for and clinical factors influencing the use of transnasal esophagoscopy (TNE). METHODS: An online survey was sent to American Broncho-Esophagological Association members, including questions on demographics, indications, and factors influencing the use of TNE. RESULTS: Sixty of 251 members (24%) completed the survey. Ninety-three percent of respondents reported academic practices, while 98% practice in medium to large urban settings. Thirty-five (58%) completed laryngology fellowships. Mean monthly TNE procedure count was 7.15 (range,
Source: The Annals of Otology, Rhinology, and Laryngology - September 21, 2018 Category: ENT & OMF Authors: Best AR, Halum SL, Parker NP Tags: Ann Otol Rhinol Laryngol Source Type: research

Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study.
Abstract AIM: To clarify the role of serum anti-Helicobacter pylori (H. pylori) antibody titers in gastric cancer. METHODS: In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophagogastroduodenoscopy and their first evaluation for H. pylori infection using a serum antibody test. We excluded patients with a history of eradication therapy. The participants were divided into four groups according to their E-plate serum antibody titer. Patients with serum antibody titers
Source: World Journal of Gastroenterology : WJG - September 21, 2018 Category: Gastroenterology Authors: Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Takahashi Y, Yamamichi N, Hata K, Seto Y, Koike K, Watanabe H, Suzuki H Tags: World J Gastroenterol Source Type: research

Correction to: Gastroesophageal reflux disease: from heartburn to Barrett esophagus, and beyond
The author name Marco G. Patti was incorrectly published. (Source: Updates in Surgery)
Source: Updates in Surgery - September 21, 2018 Category: Surgery Source Type: research

Lung Transplantation in Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)
AbstractPurpose of ReviewConnective tissue disease-related interstitial lung disease (CTD-ILD) previously was a relative contraindication to lung transplantation primarily due to extra-pulmonary involvement of the disease. Recent published information focusing on the diagnosis and management of the extra-pulmonary complexities associated with CTD-ILD that challenge the success of lung transplantation indicate similar outcomes when compared to idiopathic causes of interstitial lung disease. Recent literature examining appropriate wait-listing criteria, disease management, and outcomes after lung transplantation are discusse...
Source: Current Respiratory Care Reports - September 20, 2018 Category: Respiratory Medicine Source Type: research

Gastroesophageal Reflux After Sleeve Gastrectomy
This essay discusses the benefits and risks of gastric bypass vs sleeve gastrectomy for inducing weight loss among individuals with morbid obesity with or without gastroesophageal reflux disease. (Source: JAMA Surgery)
Source: JAMA Surgery - September 19, 2018 Category: Sports Medicine Source Type: research

Spontaneous Giant Laryngeal Granuloma in the Absence of Laryngeal Injury
We report a case of spontaneous development of multiple granulomas in a female with no history of intubation who presented with hoarseness and massive bilateral supraglottic masses obscuring her glottis. The disparity between the massive lesions and asymptomatic reflux highlights the need for further research in the pathophysiology of laryngeal granulomas. (Source: Journal of Voice)
Source: Journal of Voice - September 19, 2018 Category: ENT & OMF Authors: Ravi R. Shah, Natasha A. Mirza Source Type: research

Effect of wu chu yu tang on gastroesophageal reflux disease: randomized, double-blind, placebo-controlled trial
Publication date: Available online 18 September 2018Source: PhytomedicineAuthor(s): Yi-Sing Shih, Chang-Hai Tsai, Tsai-Chung Li, Cheng-Ju Yu, Jen-Wei Chou, Chun-Lung Feng, Kun-Teng Wang, Hsueh-Chou Lai, Ching-Liang HsiehAbstractBackgroundThe main symptoms of gastroesophageal reflux disease GERD are heartburn and acid regurgitation. Proton-pump inhibitors (PPI) are considered to be safe and effective for the treatment of GERD. In traditional Chinese medicine, wu chu yu tang (WCYT) is used to treat nausea after eating, vomiting, and diarrhea.PurposeWe designed a randomized, double-blind, placebo-controlled clinical trial to ...
Source: Phytomedicine - September 18, 2018 Category: Drugs & Pharmacology Source Type: research

Simultaneous LIBS signal and plasma density measurement for quantitative insight into signal instability at elevated pressure
Laser-induced breakdown spectroscopy (LIBS) evaluates the emission spectra of ions, radicals, and atoms generated from the breakdown of molecules by the incident laser; however, the LIBS signal is unstable at elevated pressures. To understand the cause of the signal instability, we perform ... (Source: Optics Express)
Source: Optics Express - September 18, 2018 Category: Physics Authors: Anil K. Patnaik Yue Wu Paul S. Hsu Mark Gragston Zhili Zhang James R. Gord Sukesh Roy Source Type: research

Aspiration and Dysphagia in the Neonatal Patient
Dysphagia and aspiration are commonly encountered problems in the neonatal population. It is often multifactorial in nature and management should be tailored to the individual patient. Multiple causes should be considered, including anatomic abnormalities, neurologic/developmental delay, cardiopulmonary disease/infection, and gastroesophageal reflux disease, in addition to those cases where a definitive reason may not be identified. Management should be multidisciplinary in nature and surgical intervention may be indicated in certain populations of patients. Here, we discuss the presentation, workup, and management of the ...
Source: Clinics in Perinatology - September 18, 2018 Category: Perinatology & Neonatology Authors: Nikhila Raol, Thomas Schrepfer, Christopher Hartnick Source Type: research

Refractory GERD, beyond proton pump inhibitors.
Abstract Pharmacologic therapy, surgery, minimally invasive therapies, and alternative therapies are different options available for the management of refractory GERD. The choice may depend on the cause of refractoriness. Increased gastric acid suppression therapy might be useful in the rare patients with persistent elevated esophageal acid exposure on proton pump inhibitors (PPI). Potassium-competitive acid blockers (P-CAB) might induce a more important acid inhibition than PPI. Baclofen might act as a reflux inhibitor and demonstrates a significant efficacy in rumination syndrome. The role of topical antacid-alg...
Source: Current Opinion in Pharmacology - September 18, 2018 Category: Drugs & Pharmacology Authors: Roman S, Mion F Tags: Curr Opin Pharmacol Source Type: research

Use of Esophageal pH Monitoring to Minimize Proton-Pump Inhibitor Utilization in Patients with Gastroesophageal Reflux Symptoms
ConclusionsIn patients with GER symptoms, esophageal pHmetry may avert PPI use in 50%. In the era of caution regarding PPIs, early testing may provide assurance and justification. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - September 15, 2018 Category: Gastroenterology Source Type: research

Impact of Helicobacter pylori and/or Helicobacter pylori ‐related metabolic syndrome on gastroesophageal reflux disease‐ Barrett's esophagus‐ esophageal adenocarcinoma sequence
Helicobacter, EarlyView. (Source: Helicobacter)
Source: Helicobacter - September 13, 2018 Category: Gastroenterology Authors: Michael Doulberis , Jannis Kountouras , Stergios A. Polyzos , Dimitri Tzivras , Elizabeth Vardaka , Constantinos Kountouras , Dimitrios Tzilves , Georgios Kotronis , Efimia Boutsikou , Dimitra Gialamprinou , Aristo Source Type: research

Eosinophilic Esophagitis - Pathophysiology and its Clinical Implications.
Abstract Eosinophilic Esophagitis is an antigen mediated chronic disease that is distinct from gastroesophageal reflux disease. EoE an emerging clinical problem that is rapidly growing in incidence and in recognition. It is characterized clinically by feeding dysfunction, dysphagia and reflux-like symptoms. Histologically EoE is identifiable by a dense epithelial eosinophilic infiltrate. Experimental modeling and clinical studies over the last decade have greatly improved our understanding of this disease and led to improvements in clinical understanding and the assessment of therapeutic options for patients and t...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 13, 2018 Category: Physiology Authors: Inage E, Furuta GT, Menard-Katcher C, Masterson JC Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

The first one-pot synthesis of undoped and Eu doped β-NaYF4 nanocrystals and their evaluation as efficient dyes for nanomedicine
Publication date: 1 January 2019Source: Materials Science and Engineering: C, Volume 94Author(s): Walid Mnasri, Lotfi Ben Tahar, Michel Boissière, Darine Abi Haidar, Souad AmmarAbstractPolygonal-shaped about 75 nm sized and highly crystallized Eu3+-doped β-NaYF4 particles were directly prepared under mild conditions using the polyol process. A set of operating parameters were optimized for such a purpose. A conventional heating under reflux for 30 min of a mixture of Y(III) and Eu(III) acetate, ammonium fluoride, sodium hydroxide and oleic acid (OA) dissolved in ethyleneglycol offered a pertinent material p...
Source: Materials Science and Engineering: C - September 12, 2018 Category: Materials Science Source Type: research

Impact of Toupet Versus Nissen Fundoplication on Dysphagia in Patients With Gastroesophageal Reflux Disease and Associated Preoperative Esophageal Dysmotility: A Systematic Review and Meta-Analysis.
Abstract BACKGROUND: Controversy exists regarding the best surgical approach for the management of gastroesophageal reflux disease (GORD) and associated preoperative esophageal dysmotility. Our aim was to conduct a systematic review and meta-analysis to compare the outcomes of Toupet fundoplication (TF) and Nissen fundoplication (NF) in patients with GORD and coexistent preoperative esophageal dysmotility. METHODS: We conducted a systematic search of electronic information sources, including MEDLINE, EMBASE, CINAHL, CENTRAL, ClinicalTrials.gov , and bibliographic reference lists. We applied a combination of f...
Source: Surgical Innovation - September 12, 2018 Category: Surgery Authors: Hajibandeh S, Hajibandeh S, Pugh M, Winters D, Hobbs N, Tarazi M, Panda N, Dalmia S, Mansour M, Malik S Tags: Surg Innov Source Type: research

Comparative study of acid functionization of carbon nanotube via ultrasonic and reflux mechanism
Publication date: Available online 10 September 2018Source: Journal of Environmental Chemical EngineeringAuthor(s): Lau Yien Jun, N.M. Mubarak, Lau Sie Yon, Chua Han Bing, Mohammad Khalid, E.C. AbdullahAbstractMulti-walled carbon nanotubes (MWCNTs) have a great potential in wide applications due to their extraordinary physical, thermal and mechanical properties. However, the known shortcomings, such as hydrophobic nature, poor solubility and dispersibility in most solvents have impeded the technology to further develop. In the present study, various types of acid functionalized MWNCTs (f-MWCNTs) samples were prepared. The ...
Source: Journal of Environmental Chemical Engineering - September 11, 2018 Category: Chemistry Source Type: research

Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders
AbstractAtopic disorders and gastroesophageal reflux disease (GERD) are some of the most common medical conditions treated by primary care physicians and specialists alike. The observation that atopic disorders, like asthma, allergic rhinitis and sinusitis, food allergies, atopic dermatitis, contact dermatitis, and eosinophilic esophagitis are common comorbidities in patients with GERD raises the question of the nature of the relationship that may exist between GERD and atopic disorders. In this article, we review the pathophysiology of GERD, its effect on the immune system, the effect of acid-blocking medications on aller...
Source: Clinical Reviews in Allergy and Immunology - September 11, 2018 Category: Allergy & Immunology Source Type: research

Endoscopic augmentation of gastroesophageal junction using a full-thickness endoscopic suturing device
Conclusions The use of a novel endoscopic suturing technique for the treatment of GERD is feasible and safe. The procedure resulted in short-term GERD symptom improvement. Further prospective studies using refined techniques are currently underway to improve durability and to prove efficacy. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - September 11, 2018 Category: Gastroenterology Authors: Han, Jimin Chin, Matthew Fortinsky, Kyle J. Sharaiha, Reem Gostout, Christopher J. Chang, Kenneth J. Tags: Original article Source Type: research

Synthesis, molecular modeling and biological evaluation of 5-arylidene-N,N-diethylthiobarbiturates as potential α-glucosidase inhibitors.
CONCLUSION Our present study has shown that Compunds 6, 5, 17, 11 exhibited IC50 values of 0.0006 ± 0.0002, 18.91 ± 0.005, 19.18 ± 0.002, 36.91 ± 0.003 μM, respectively. The studies were supported by in silico data analysis. PMID: 30207240 [PubMed - as supplied by publisher] (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - September 11, 2018 Category: Chemistry Authors: Khan M, Khan S, Ul Mulk A, Ur Rahman A, Wadood A, Shams S, Ashraf M, Rahman J, Hameed A, Hussain Z, Khan A, Zaman K, Khan KM, Perveen S Tags: Med Chem Source Type: research

Mucosal permeability and mast cells as targets for functional gastrointestinal disorders.
rholm JD Abstract The intestinal mucosa is constantly exposed to harmful luminal content, and uptake is closely controlled and regulated by neuro-immune factors. If control is broken, it might lead to ongoing enhanced mucosal permeability, potentially resulting in functional gastrointestinal disorders. The importance of mast cells in the regulation of the mucosal barrier has become obvious, and increased numbers and more activated mast cells have been observed in irritable bowel syndrome, functional dyspepsia and gastroesophageal reflux disease. To target the disturbed mucosal permeability, directly or via mast ce...
Source: Current Opinion in Pharmacology - September 11, 2018 Category: Drugs & Pharmacology Authors: Keita ÅV, Söderholm JD Tags: Curr Opin Pharmacol Source Type: research

Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders
AbstractAtopic disorders and gastroesophageal reflux disease (GERD) are some of the most common medical conditions treated by primary care physicians and specialists alike. The observation that atopic disorders, like asthma, allergic rhinitis and sinusitis, food allergies, atopic dermatitis, contact dermatitis, and eosinophilic esophagitis are common comorbidities in patients with GERD raises the question of the nature of the relationship that may exist between GERD and atopic disorders. In this article, we review the pathophysiology of GERD, its effect on the immune system, the effect of acid-blocking medications on aller...
Source: Clinical Reviews in Allergy and Immunology - September 11, 2018 Category: Allergy & Immunology Source Type: research

Optimizing the Use of Medications and Other Therapies in Infant Gastroesophageal Reflux
AbstractGastroesophageal reflux (GER) is the retrograde movement of gastric (and sometimes duodenal) contents into the esophagus. While the majority of GER is physiologic, for patients, it can be associated with symptoms. While some symptoms are merely bothersome (crying), others can be life threatening (cough, gagging, choking). The main driver of GER in infants is the frequent feedings that produce increased intra-abdominal pressure, which is known to trigger transient relaxations of the lower esophageal sphincter. The recent 2018 clinical practice guidelines reported by the North American and European Societies for Pedi...
Source: Pediatric Drugs - September 10, 2018 Category: Pediatrics Source Type: research

An Unanticipated Airway Finding After Orotracheal Intubation With a GlideScope Videolaryngoscope
A 57-year-old, 119-kg, 170-cm (body mass index of 41) man with a history of atypical chest pain, hypertension, hyperlipidemia, severe obstructive sleep apnea treated with continuous positive airway pressure, gastroesophageal reflux disease, chronic cervical radiculopathy, and alcohol use disorder presented to the authors ’ institution with acute periumbilical and right-sided abdominal pain, nausea, vomiting, and diaphoresis. He denied fever, new chest pain or pressure, and other gastrointestinal complaints. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - September 10, 2018 Category: Anesthesiology Authors: Paul S. Pagel, Marc A. Chapel, Alexander R. Georgeson, Elizabeth A. Traudt, Ryan E. Little, Todd A. Loehrl, Lewis B. Somberg Tags: Diagnostic Dilemma Source Type: research

Mapping of the Gastrointestinal Short Form Questionnaire (GSF-Q) into EQ-5D-3L and SF-6D in patients with gastroesophageal reflux disease
The short, self-administered Gastroesophageal Reflux Disease (GERD) Symptom Frequency Questionnaire (GSFQ) is a specific Quality of Life (QoL) instrument which measures the impact of GERD symptoms on QoL. This... (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - September 10, 2018 Category: International Medicine & Public Health Authors: Manuel Monroy, Miguel A. Ruiz, Javier Rejas and Javier Soto Tags: Research Source Type: research

Optimizing the Use of Medications and Other Therapies in Infant Gastroesophageal Reflux.
Abstract Gastroesophageal reflux (GER) is the retrograde movement of gastric (and sometimes duodenal) contents into the esophagus. While the majority of GER is physiologic, for patients, it can be associated with symptoms. While some symptoms are merely bothersome (crying), others can be life threatening (cough, gagging, choking). The main driver of GER in infants is the frequent feedings that produce increased intra-abdominal pressure, which is known to trigger transient relaxations of the lower esophageal sphincter. The recent 2018 clinical practice guidelines reported by the North American and European Societie...
Source: Paediatric Drugs - September 10, 2018 Category: Pediatrics Authors: Ciciora SL, Woodley FW Tags: Paediatr Drugs Source Type: research

Optimizing the Use of Medications and Other Therapies in Infant Gastroesophageal Reflux
AbstractGastroesophageal reflux (GER) is the retrograde movement of gastric (and sometimes duodenal) contents into the esophagus. While the majority of GER is physiologic, for patients, it can be associated with symptoms. While some symptoms are merely bothersome (crying), others can be life threatening (cough, gagging, choking). The main driver of GER in infants is the frequent feedings that produce increased intra-abdominal pressure, which is known to trigger transient relaxations of the lower esophageal sphincter. The recent 2018 clinical practice guidelines reported by the North American and European Societies for Pedi...
Source: Pediatric Drugs - September 10, 2018 Category: Pediatrics Source Type: research

Prospective Single Arm Study on the Effect of Ilaprazole in Patients with Heartburn but No Reflux Esophagitis.
Abstract PURPOSE: Patients with gastroesophageal reflux disease without esophagitis show varying responses to proton pump inhibitors (PPIs). The aim of this study was to objectively evaluate the effect of a new PPI, ilaprazole, on patients with heartburn but without reflux esophagitis. MATERIALS AND METHODS: This prospective study was performed on 20 patients with heartburn but without reflux esophagitis. All patients underwent upper endoscopy and 24-hr combined multichannel intraluminal impedance and pH esophageal monitoring (MII-pH). They were then treated with ilaprazole (20 mg) once daily for 4 weeks. The...
Source: Yonsei Medical Journal - September 8, 2018 Category: Universities & Medical Training Authors: Song IJ, Kim HK, Lee NK, Lee SK Tags: Yonsei Med J Source Type: research

Outcomes After Metabolic Surgery in Asians —a Meta-analysis
ConclusionRYGB results in better weight loss compared to SG in Asians, but the rate of T2DM resolution/improvement and improvement of hypertension appears to be similar. In Asian patients without symptoms of gastro-esophageal reflux disease in whom metabolic surgery is performed mainly for T2DM and metabolic syndrome, SG may be the surgery of choice. (Source: Obesity Surgery)
Source: Obesity Surgery - September 8, 2018 Category: Surgery Source Type: research

Convenient Method of Measuring Baseline Impedance for Distinguishing Patients with Functional Heartburn from those with Proton Pump Inhibitor-Resistant Endoscopic Negative Reflux Disease
Conclusion: Measuring the simple MBI is a quick method and is useful for distinguishing patients with FH from those in a cohort with PPI-refractory NERD.Digestion (Source: Digestion)
Source: Digestion - September 7, 2018 Category: Gastroenterology Source Type: research

Non-metal-templated approaches to bis(borane) derivatives of macrocyclic dibridgehead diphosphines via alkene metathesis
Abstract Two routes to the title compounds are evaluated. First, a ca. 0.01 M CH2Cl2 solution of H3B·P((CH2)6CH=CH2)3 (1·BH3) is treated with 5 mol % of Grubbs' first generation catalyst (0 °C to reflux), followed by H2 (5 bar) and Wilkinson's catalyst (55 °C). Column chromatography affords H3B·P(n-C8H17)3 (1%), H3B·P((CH2)13CH2)(n-C8H17) (8%; see text for tie bars that indicate additional phosphorus–carbon linkages, which are coded in the abstract with italics), H3B·P((CH2)13CH2)((CH2)14)P((CH2)13CH2)·BH3 (6·2BH3, 10%), in,out-H3B·P((CH2)14)3P&m...
Source: Beilstein Journal of Organic Chemistry - September 7, 2018 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: alkene metathesis crystal structures homeomorphic isomerization hydrogenation in/out isomers phosphine boranes Full Research Paper Source Type: research

Congenital myopathies: general and ryr1
Mutations in genes that impair sarcomeric force generation and affect muscle contraction cause myopathies of variable severity. TNNC2 encodes fast skeletal troponin C, an important component of the troponin complex, for which human disease mutations have not yet been reported. Here we report two families with a distinct, dominantly-inherited congenital myopathy with rare, heterozygous, predicted-to-be-damaging mutations in TNNC2. Patient 1 (P1) of Family 1 (F1) is a 26-year-old male who presented with maternal polyhydramnios treated with serial amniocenteses, significant congenital onset weakness, vocal cord paralysis and ...
Source: Neuromuscular Disorders - September 6, 2018 Category: Neurology Authors: S. Donkervoort, P. Mohassel, N. Voermans, C. Quinn, M. van de Locht, J. de Winter, S. Conijn, M. Helmes, L. Medne, O. Lopes Abath Neto, S. Moore, C. Ottenheijm, A.R. Foley, C. B önnemann Source Type: research

Laparoscopic Hill repair: 25-year follow-up
ConclusionLHR shows excellent long-term durability and quality of life similar to the open Hill repair, with 85% good to excellent results at a median follow-up of 19  years and a reoperation rate under 10%. It is surmised that Hill suture fixation of the gastroesophageal junction to the preaortic fascia may confer unique structural integrity compared to other repairs. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - September 6, 2018 Category: Surgery Source Type: research

Comorbidities of IPF: How do they impact on prognosis
Publication date: Available online 5 September 2018Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Sebastiano Emanuele Torrisi, Ada Vancheri, Mauro Pavone, Gianluca Sambataro, Stefano Palmucci, Carlo VancheriAbstractIdiopathic Pulmonary Fibrosis (IPF) is a severe parenchymal lung disease characterized by an intense deposition of collagen in the interstitial spaces. The introduction of anti-fibrotic drugs increased patients' life expectancy highlighting the role of comorbidities in patients' management and prognosis. IPF is frequently associated with other diseases mainly because of its onset during middle age a...
Source: Pulmonary Pharmacology and Therapeutics - September 6, 2018 Category: Respiratory Medicine Source Type: research

Low Prevalence of Suspected Barrett ’s Esophagus in Gastroesophageal Reflux Disease Without Alarm Symptoms
Esophagogastroduodenoscopy (EGD) is frequently used to evaluate gastroesophageal reflux disease (GERD) without alarm symptoms, although the benefits are not clear. We aimed determine the prevalence of uncomplicated GERD as an indication for EGD, the demographic characteristics of these patients, and the endoscopic outcomes of these procedures. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 6, 2018 Category: Gastroenterology Authors: Emery C. Lin, Jennifer Holub, David Lieberman, Chin Hur Source Type: research

Visceral and neural manipulation in children with cerebral palsy and chronic constipation: five case reports
In many children with cerebral palsy (CP), constipation is chronic, adversely affecting their quality of life. Treatment may require invasive measures beyond diet such as medications, digital stimulation, enemas, and hospitalization. Children with cerebral palsy and chronic constipation often have resulting co-morbidities such as increased frequency of seizures, abdominal pain, decreased appetite, increased gastro-esophageal reflux, increased irritability, hospitalizations, and possible need for surgery. (Source: Explore)
Source: Explore - September 6, 2018 Category: Nursing Authors: Jean Anne Zollars, Margaret Armstrong, Sandra Whisler, Susan Williamson Tags: Case Report Source Type: research

Low Prevalence of Suspected Barrett ’s Esophagus in Patients with Gastroesophageal Reflux Disease Without Alarm Symptoms
Esophagogastroduodenoscopy (EGD) is frequently used to evaluate gastroesophageal reflux disease (GERD) without alarm symptoms, although the benefits are not clear. We aimed to determine the prevalence of uncomplicated GERD as an indication for EGD, the demographic characteristics of these patients, and the endoscopic outcomes of these procedures. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 6, 2018 Category: Gastroenterology Authors: Emery C. Lin, Jennifer Holub, David Lieberman, Chin Hur Source Type: research

Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma
ConclusionsSpecific polymorphisms in vitamin D metabolism-related genes are associated with the likelihood of reflux –BE–EAC progression. Identifying such polymorphisms may aid in development of better surveillance and diagnostic and therapeutic protocols. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 5, 2018 Category: Cancer & Oncology Source Type: research

Correlation of sleep-disordered breathing and laryngopharyngeal reflux: a two-channel triple-sensor pHmetry catheter study
ConclusionThe prevalence of GER and LPR is found to be high in patients with sleep-disordered breathing. There is no significant relationship between OSAS severity and GER and LPR grade or respiratory events and reflux episodes with regard to timing. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - September 4, 2018 Category: ENT & OMF Source Type: research

The Effect of Alginate in Gastroesophageal Reflux in Infants
AbstractBackgroundGuidelines are contradictory regarding the use of alginate in infants with persisting gastroesophageal reflux (GER). While The British National Institute for Health and Care (NICE) guidelines consider alginate as a treatment option, the guidelines of the European and North-American Societies for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN, NASPGHAN) do not recommend alginates.AimsWe assessed the efficacy of alginate to reduce GER episodes in infants.MethodsIn a prospective, observational study, we consecutively enrolled all infants referred for pH-multiple intraluminal impedance (pH-MII)...
Source: Pediatric Drugs - September 4, 2018 Category: Pediatrics Source Type: research

The Effect of Alginate in Gastroesophageal Reflux in Infants.
Abstract BACKGROUND: Guidelines are contradictory regarding the use of alginate in infants with persisting gastroesophageal reflux (GER). While The British National Institute for Health and Care (NICE) guidelines consider alginate as a treatment option, the guidelines of the European and North-American Societies for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN, NASPGHAN) do not recommend alginates. AIMS: We assessed the efficacy of alginate to reduce GER episodes in infants. METHODS: In a prospective, observational study, we consecutively enrolled all infants referred for pH-multiple int...
Source: Paediatric Drugs - September 4, 2018 Category: Pediatrics Authors: Salvatore S, Ripepi A, Huysentruyt K, van de Maele K, Nosetti L, Agosti M, Salvatoni A, Vandenplas Y Tags: Paediatr Drugs Source Type: research

The Effect of Alginate in Gastroesophageal Reflux in Infants
AbstractBackgroundGuidelines are contradictory regarding the use of alginate in infants with persisting gastroesophageal reflux (GER). While The British National Institute for Health and Care (NICE) guidelines consider alginate as a treatment option, the guidelines of the European and North-American Societies for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN, NASPGHAN) do not recommend alginates.AimsWe assessed the efficacy of alginate to reduce GER episodes in infants.MethodsIn a prospective, observational study, we consecutively enrolled all infants referred for pH-multiple intraluminal impedance (pH-MII)...
Source: Pediatric Drugs - September 4, 2018 Category: Pediatrics Source Type: research

Feasibility Trial of the Newly Introduced Optical Enhancement Technology in Patients with Gastroesophageal Reflux Disease
Conclusions: The newly introduced OE technology significantly improves the diagnosis of GERD compared to HD-WLE. The results should be confirmed in a multicenter trial.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - September 2, 2018 Category: Gastroenterology Source Type: research

On-Demand Therapy with Proton Pump Inhibitors for Maintenance Treatment of Nonerosive Reflux Disease or Mild Erosive Esophagitis: A Systematic Review and Meta-Analysis.
Conclusions: On-demand PPI treatment is effective for many patients with NERD or mild EE. Although not FDA-approved, it may be adequate for those patients whose symptoms are controlled to their satisfaction. PMID: 30158966 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - September 1, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Aspiration: /aspə’rāSH(ə)n/ Noun An Ambiguous Term Used for a Diagnosis of Uncertainty
This article reviews the literature and classifies 13 distinct syndromes, grouped into 3 categories to help delineate the different disease states associated with pulmonary aspiration. Chronic anaerobic pulmonary infection should be most precisely referred to as anaerobic pneumonia. The commonly used term, aspiration pneumonia, is misleading to clinicians and should be abandoned. (Source: Clinical Pulmonary Medicine)
Source: Clinical Pulmonary Medicine - September 1, 2018 Category: Respiratory Medicine Tags: Topics in Pulmonary Medicine Source Type: research

Correlation between esophageal pH-metry and esophagitis in gastroesophageal reflux disease in children
Gastroesophageal reflux (GER) is the intermittent or permanent passage of stomach content into the esophagus and gastroesophageal reflux disease (GERD) is the reflux which triggers a whole set of symptoms or complications. The study compares the 24-hours esophageal pH-metry, used for diagnosis of the GERD, with the esophagitis degree observed at the upper digestive endoscopy. 72 children were included, aged over 4 years old, admitted in a pediatric gastroenterology regional center in Northeast Romania, diagnosed with GERD by 24 hours pH-metry (with a positive Boix–Ochoa score), which also underwent the upper diges...
Source: Medicine - September 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research