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miR-378a-5p represses Barrett's esophagus cells proliferation, migration and invasion through targeting TSPAN8
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):97-103. doi: 10.14715/cmb/2024.70.2.14.ABSTRACTBarrett's esophagus (BE) belongs to a pathological phenomenon occurring in the esophagus, this paper intended to unveil the underlying function of miR-378a-5p and its target TSPAN8 in BE progression. GEO analysis was conducted to determine differentially expressed genes in BE samples. Non-dysplastic metaplasia BE samples, high-grade dysplastic BE samples and controls were collected from subjects. CP-A and CP-B cells were exposed to bile acids (BA) to mimic gastroesophageal reflux in BE cells. RT-qPCR as well as western blot wer...
Source: Mol Biol Cell - March 2, 2024 Category: Molecular Biology Authors: Xudong Xie Duo Wei Source Type: research

miR-378a-5p represses Barrett's esophagus cells proliferation, migration and invasion through targeting TSPAN8
Cell Mol Biol (Noisy-le-grand). 2024 Feb 29;70(2):97-103. doi: 10.14715/cmb/2024.70.2.14.ABSTRACTBarrett's esophagus (BE) belongs to a pathological phenomenon occurring in the esophagus, this paper intended to unveil the underlying function of miR-378a-5p and its target TSPAN8 in BE progression. GEO analysis was conducted to determine differentially expressed genes in BE samples. Non-dysplastic metaplasia BE samples, high-grade dysplastic BE samples and controls were collected from subjects. CP-A and CP-B cells were exposed to bile acids (BA) to mimic gastroesophageal reflux in BE cells. RT-qPCR as well as western blot wer...
Source: Cellular and Molecular Biology - March 2, 2024 Category: Molecular Biology Authors: Xudong Xie Duo Wei Source Type: research

Cystic fibrosis and fat malabsorption: Pathophysiology of the cystic fibrosis gastrointestinal tract and the impact of highly effective CFTR modulator therapy
Nutr Clin Pract. 2024 Apr;39 Suppl 1:S57-S77. doi: 10.1002/ncp.11122.ABSTRACTCystic fibrosis (CF) is a progressive, genetic, multi-organ disease affecting the respiratory, digestive, endocrine, and reproductive systems. CF can affect any aspect of the gastrointestinal (GI) tract, including the esophagus, stomach, small intestine, colon, pancreas, liver, and gall bladder. GI pathophysiology associated with CF results from CF membrane conductance regulator (CFTR) dysfunction. The majority of people with CF (pwCF) experience exocrine pancreatic insufficiency resulting in malabsorption of nutrients and malnutrition. Additional...
Source: Nutrition in Clinical Practice - March 2, 2024 Category: Nutrition Authors: Catherine M McDonald Elizabeth K Reid John F Pohl Tatiana K Yuzyuk Laura M Padula Kay Vavrina Kimberly Altman Source Type: research

Multicystic renal dysplasia, a histomorphological spectrum: Seven years experience from a tertiary care hospital
CONCLUSION: This series has been presented to highlight the various histomorphological features of MCDK. MCDK can be managed conservatively in most of cases due to autoinvolution and, hence, needs to be differentiated from other close differentials like polycystic kidney disease, cystic nephroma, and cystic partially differentiated nephroblastoma in order to avoid unnecessary surgical intervention.PMID:38427756 | DOI:10.4103/ijpm.ijpm_202_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - March 1, 2024 Category: Pathology Authors: Kanika Gupta Shramana Mandal Varuna Mallya Meeta Singh Nita Khurana Yogesh K Sarin Source Type: research