Polymorphisms of Genes Related to Function and Metabolism of Vitamin D in Esophageal Adenocarcinoma
ConclusionsSpecific polymorphisms in vitamin D metabolism-related genes are associated with the likelihood of reflux –BE–EAC progression. Identifying such polymorphisms may aid in development of better surveillance and diagnostic and therapeutic protocols. (Source: Journal of Gastrointestinal Cancer)
Source: Journal of Gastrointestinal Cancer - September 5, 2018 Category: Cancer & Oncology Source Type: research

Correlation of sleep-disordered breathing and laryngopharyngeal reflux: a two-channel triple-sensor pHmetry catheter study
ConclusionThe prevalence of GER and LPR is found to be high in patients with sleep-disordered breathing. There is no significant relationship between OSAS severity and GER and LPR grade or respiratory events and reflux episodes with regard to timing. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - September 4, 2018 Category: ENT & OMF Source Type: research

The Effect of Alginate in Gastroesophageal Reflux in Infants
AbstractBackgroundGuidelines are contradictory regarding the use of alginate in infants with persisting gastroesophageal reflux (GER). While The British National Institute for Health and Care (NICE) guidelines consider alginate as a treatment option, the guidelines of the European and North-American Societies for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN, NASPGHAN) do not recommend alginates.AimsWe assessed the efficacy of alginate to reduce GER episodes in infants.MethodsIn a prospective, observational study, we consecutively enrolled all infants referred for pH-multiple intraluminal impedance (pH-MII)...
Source: Pediatric Drugs - September 4, 2018 Category: Pediatrics Source Type: research

The Effect of Alginate in Gastroesophageal Reflux in Infants.
Abstract BACKGROUND: Guidelines are contradictory regarding the use of alginate in infants with persisting gastroesophageal reflux (GER). While The British National Institute for Health and Care (NICE) guidelines consider alginate as a treatment option, the guidelines of the European and North-American Societies for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN, NASPGHAN) do not recommend alginates. AIMS: We assessed the efficacy of alginate to reduce GER episodes in infants. METHODS: In a prospective, observational study, we consecutively enrolled all infants referred for pH-multiple int...
Source: Paediatric Drugs - September 4, 2018 Category: Pediatrics Authors: Salvatore S, Ripepi A, Huysentruyt K, van de Maele K, Nosetti L, Agosti M, Salvatoni A, Vandenplas Y Tags: Paediatr Drugs Source Type: research

The Effect of Alginate in Gastroesophageal Reflux in Infants
AbstractBackgroundGuidelines are contradictory regarding the use of alginate in infants with persisting gastroesophageal reflux (GER). While The British National Institute for Health and Care (NICE) guidelines consider alginate as a treatment option, the guidelines of the European and North-American Societies for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN, NASPGHAN) do not recommend alginates.AimsWe assessed the efficacy of alginate to reduce GER episodes in infants.MethodsIn a prospective, observational study, we consecutively enrolled all infants referred for pH-multiple intraluminal impedance (pH-MII)...
Source: Pediatric Drugs - September 4, 2018 Category: Pediatrics Source Type: research

Feasibility Trial of the Newly Introduced Optical Enhancement Technology in Patients with Gastroesophageal Reflux Disease
Conclusions: The newly introduced OE technology significantly improves the diagnosis of GERD compared to HD-WLE. The results should be confirmed in a multicenter trial.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - September 2, 2018 Category: Gastroenterology Source Type: research

On-Demand Therapy with Proton Pump Inhibitors for Maintenance Treatment of Nonerosive Reflux Disease or Mild Erosive Esophagitis: A Systematic Review and Meta-Analysis.
Conclusions: On-demand PPI treatment is effective for many patients with NERD or mild EE. Although not FDA-approved, it may be adequate for those patients whose symptoms are controlled to their satisfaction. PMID: 30158966 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - September 1, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Aspiration: /aspə’rāSH(ə)n/ Noun An Ambiguous Term Used for a Diagnosis of Uncertainty
This article reviews the literature and classifies 13 distinct syndromes, grouped into 3 categories to help delineate the different disease states associated with pulmonary aspiration. Chronic anaerobic pulmonary infection should be most precisely referred to as anaerobic pneumonia. The commonly used term, aspiration pneumonia, is misleading to clinicians and should be abandoned. (Source: Clinical Pulmonary Medicine)
Source: Clinical Pulmonary Medicine - September 1, 2018 Category: Respiratory Medicine Tags: Topics in Pulmonary Medicine Source Type: research

Correlation between esophageal pH-metry and esophagitis in gastroesophageal reflux disease in children
Gastroesophageal reflux (GER) is the intermittent or permanent passage of stomach content into the esophagus and gastroesophageal reflux disease (GERD) is the reflux which triggers a whole set of symptoms or complications. The study compares the 24-hours esophageal pH-metry, used for diagnosis of the GERD, with the esophagitis degree observed at the upper digestive endoscopy. 72 children were included, aged over 4 years old, admitted in a pediatric gastroenterology regional center in Northeast Romania, diagnosed with GERD by 24 hours pH-metry (with a positive Boix–Ochoa score), which also underwent the upper diges...
Source: Medicine - September 1, 2018 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Vonoprazan versus proton pump inhibitors for the management of gastroesophageal reflux disease: A protocol for a systematic review with meta-analysis
Conclusion: To our knowledge, this systematic review and meta-analysis will be the first to evaluate existing research comparing Vonoprazan and PPIs in GERD. Our study will provide information about the effect of vonoprazan and PPIs in GERD in RCTs. The review will benefit patients, healthcare providers, and policymakers. (Source: Medicine)
Source: Medicine - September 1, 2018 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Smokeless Tobacco and Cigar and/or Pipe Are Risk Factors for Barrett Esophagus in Male Patients With Gastroesophageal Reflux  Disease
To investigate the effect of smokeless tobacco (ST), cigar and/or pipe smoking (CP) on the development of Barrett esophagus (BE) in white male patients with gastroesophageal reflux disease (GERD). (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - September 1, 2018 Category: Internal Medicine Authors: Wytske M. Westra, Lori S. Lutzke, Nahid S. Mostafavi, Alev L. Roes, Silvia Calpe, Kenneth K. Wang, Kausilia K. Krishnadath Tags: Original article Source Type: research

Advising patients about acidic exposure and dental erosion
Dental erosion can occur after exposure to acids either in the diet or as a result of physical conditions. Extrinsic dietary acids come from foods or beverages that are consumed. Exposures to these acids can be increased by specific behaviors such as holding liquids in the mouth or swishing with them. In contrast, teeth are exposed to intrinsic acids when the patient has disorders such as anorexia nervosa, bulimia nervosa, rumination syndrome, or gastroesophageal reflux. The science supporting the role of dietary risk factors for erosion and the actions clinicians can take to protect patients at risk for erosion were explo...
Source: Dental Abstracts - September 1, 2018 Category: Dentistry Tags: Hands On Source Type: research

Comment on: Acid and non-acid gastroesophageal reflux after single anastomosis gastric bypass.
PMID: 30268322 [PubMed - in process] (Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery)
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - September 1, 2018 Category: Surgery Authors: Deitel M, Rheinwalt KP, Musella M, Weiner R, Kular KS, Peraglia C, Prasad A, Luciani RC, Sakran N, Plamper A Tags: Surg Obes Relat Dis Source Type: research

Comment on: Acid and non-acid gastroesophageal reflux after single anastomosis gastric bypass
The article on gastroesophageal reflux (GER) after single anastomosis gastric bypass by Doulami et al [1] is based on an erroneous operative technique. They cite papers which use the correct SAGB technique, but their own SAGB operation uses techniques that lead to problems. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - September 1, 2018 Category: Surgery Authors: M. Deitel, K.P. Rheinwalt, M. Musella, R. Weiner, K.S. Kular, C. Peraglia, A. Prasad, R.C. Luciani, N. Sakran, A. Plamper Tags: Letter to the Editor Source Type: research

Gastroesophageal reflux disease: from heartburn to Barrett esophagus, and beyond
(Source: Updates in Surgery)
Source: Updates in Surgery - September 1, 2018 Category: Surgery Source Type: research

Gastroesophageal reflux and Barrett ’s esophagus: a pathway to esophageal adenocarcinoma
AbstractThe incidence of esophageal adenocarcinoma (EAC) has increased significantly in Western countries. The rising prevalence of gastroesophageal reflux disease (GERD) and obesity has played a major role in the increasing numbers of EAC. Approximately 10 –15% of patients with GERD will develop Barrett’s esophagus (BE). This metaplastic transformation is due to the chronic injury produced by repeated reflux episodes and involves genetic mutations that can lead to a malignant transformation. Ultimately, the development of EAC is characterized by t he sequence BE metaplasia–dysplasia–invasive carcin...
Source: Updates in Surgery - September 1, 2018 Category: Surgery Source Type: research

Pathophysiology of gastroesophageal reflux disease: how an antireflux procedure works (or does not work)
AbstractThe pathophysiology of gastroesophageal reflux disease is complex and linked to an intricate valve mechanism at the level of the esophagogastric junction that must counteract a trans-diaphragmatic pressure gradient, which is constantly forcing gastric contents upwards. Surgical antireflux therapy is usually aimed towards reinforcement of this valve mechanism. The valve mechanism is made up by the intra-abdominal length of the esophagus; the diaphragmatic sphincter, the angle of His, and the lower esophageal sphincter: all these elements must be restored with an antireflux procedure. Hiatal approximation and fundopl...
Source: Updates in Surgery - September 1, 2018 Category: Surgery Source Type: research

Laparoscopic antireflux surgery: how I do it?
AbstractGastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the US, and its prevalence is increasing worldwide. Lifestyle modifications and proton pump inhibitors (PPI) are effective in the majority of patients. However, some patients will become candidates for surgical intervention, because they have partial control of symptoms, do not want to be on long-term medical treatment, or suffer complications related to PPI. In these patients, a properly executed laparoscopic antireflux surgery controls esophageal and extra-esophageal symptoms and avoids life-long medical therapy. Important techni...
Source: Updates in Surgery - September 1, 2018 Category: Surgery Source Type: research

Comparison of the outcome of laparoscopic procedures for GERD
AbstractA total laparoscopic fundoplication has become the procedure of choice for the surgical treatment of gastroesophageal reflux disease in patients with normal esophageal motility, with reduced postoperative pain, faster recovery and similar long-term outcomes compared to conventional open total fundoplication. Most controversial surgical aspects are the division of the short gastric vessels and the insertion of a bougie to calibrate the wrap. The anterior 180 ° and the posterior partial fundoplications lead to similar control of heartburn when compared to total fundoplication with lower risk of dysphagia. However...
Source: Updates in Surgery - September 1, 2018 Category: Surgery Source Type: research

Magnetic sphincter augmentation for gastroesophageal reflux disease: review of clinical studies
AbstractUse of the magnetic sphincter augmentation (MSA) device for the laparoscopic treatment of gastroesophageal reflux disease is increasing since the first clinical implant performed a decade ago. The MSA procedure is a minimally invasive and highly standardized surgical option for patients who are partially responders to proton-pump inhibitors, which have troublesome regurgitation or develop progressive symptoms despite continuous medical therapy. The procedure has proven to be highly effective in improving typical reflux symptoms, reducing the use of proton-pump inhibitors, and decreasing esophageal acid exposure. Ob...
Source: Updates in Surgery - September 1, 2018 Category: Surgery Source Type: research

Chromosome 16p13.11 Microdeletion Syndrome in a Newborn: A Case Study.
We present a case report of an infant diagnosed with chromosome 16p13.11 microdeletion. A discussion of genetic influences, associated clinical manifestations, diagnostics, management, and health promotion strategies are presented to establish core knowledge of chromosome 16p13.11 microdeletion. PMID: 30567812 [PubMed - in process] (Source: Neonatal Network)
Source: Neonatal Network - September 1, 2018 Category: Perinatology & Neonatology Authors: Smith AE, Jnah A, Newberry D Tags: Neonatal Netw Source Type: research

Asthma COPD overlap: Impact of associated comorbidities
The objective of this review is to describe current knowledge and clinical implications of the overlapping features of asthma and COPD, and discuss the prevalence and impact of comorbidities, such as osteoporosis, cardiovascular disease, gastroesophageal reflux disease, and depression, in this subgroup of patients. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 31, 2018 Category: Respiratory Medicine Source Type: research

Evaluation of resection of the gastroesophageal junction and jejunal interposition (Merendino procedure) as a rescue procedure in patients with a failed redo antireflux procedure. A single-center experience
Primary antireflux surgery has high success rates but 5 to 20% of patients undergoing antireflux operations can experience recurrent reflux and dysphagia, requiring reoperation. Different surgical approaches a... (Source: BMC Surgery)
Source: BMC Surgery - August 30, 2018 Category: Surgery Authors: Apostolos Analatos, Mats Lindblad, Ioannis Rouvelas, Peter Elbe, Lars Lundell, Magnus Nilsson, Andrianos Tsekrekos and Jon A. Tsai Tags: Research article Source Type: research

Model to Select On-Therapy vs Off-Therapy Tests for Patients with Refractory Esophageal or Extra-Esophageal Symptoms
It is not clear whether we should test for reflux in patients with refractory heartburn or extra-esophageal reflux (EER) symptoms, such as cough, hoarseness, or asthma. Guidelines recommend testing patients by pH monitoring when they are on or off acid-suppressive therapies based on pre-test probability of reflux, determined by expert consensus. However, it is not clear what constitutes a low or high pre-test probability of reflux in these patients. We aimed to develop a model that clinicians can use at bedside to estimate pre-test probability of abnormal reflux. (Source: Gastroenterology)
Source: Gastroenterology - August 28, 2018 Category: Gastroenterology Authors: Dhyanesh A. Patel, Rohit Sharda, Yash A. Choksi, James C. Slaughter, Tina Higginbotham, C Gaelyn Garrett, David O. Francis, Karthik Ravi, Stephen Hasak, David Katzka, C. Prakash Gyawali, Michael F. Vaezi Source Type: research

Airway inflammation and injury in children with prevalent weakly acidic gastroesophageal refluxes
In children with gastroesophageal reflux (GER) both acid refluxes (AR) and weakly acidic refluxes (WAR) can induce respiratory symptoms (RS). (Source: Respiratory Medicine)
Source: Respiratory Medicine - August 28, 2018 Category: Respiratory Medicine Authors: Oliviero Sacco, Michela Silvestri, Michele Ghezzi, Antonino Capizzi, Giovanni A. Rossi Source Type: research

Model to Select On-Therapy vs Off-Therapy Tests for Patients With Refractory Esophageal or Extraesophageal Symptoms
It is not clear whether we should test for reflux in patients with refractory heartburn or extraesophageal reflux (EER) symptoms, such as cough, hoarseness, or asthma. Guidelines recommend testing patients by pH monitoring when they are on or off acid-suppressive therapies based on pretest probability of reflux, determined by expert consensus. However, it is not clear what constitutes a low or high pretest probability of reflux in these patients. We aimed to develop a model that clinicians can use at bedside to estimate pretest probability of abnormal reflux. (Source: Gastroenterology)
Source: Gastroenterology - August 28, 2018 Category: Gastroenterology Authors: Dhyanesh A. Patel, Rohit Sharda, Yash A. Choksi, James C. Slaughter, Tina Higginbotham, C. Gaelyn Garrett, David O. Francis, Karthik Ravi, Stephen Hasak, David Katzka, C. Prakash Gyawali, Michael F. Vaezi Tags: Clinical —Alimentary Tract Source Type: research

Interactions between Helicobacter pylori and gastroesophageal reflux disease
In conclusion, as the determinative factors affecting GERD involving in HP, detailed data on the location of gastric inflammation and CagA positivity should be obtained by the studies at future. (Source: Esophagus)
Source: Esophagus - August 27, 2018 Category: Gastroenterology Source Type: research

A comparison between dextranomer/ hyaluronic acid and polyacrylate polyalcohol copolymer as bulking agents for treating primary vesicoureteral reflux.
Abstract PURPOSE: In recent years, endoscopic subureteral injection has gained popularity as a therapeutic alternative to open surgery because of its high success rates and low morbidity. We compared the success and complication rates of Polyacrylate polyalcohol copolymer (PPC) and Dextranomer/Hyaluronic acid (Dx/HA) in the endoscopic treatment of VUR. MATERIALS & METHODS: We retrospectively reviewed the patients who underwent endoscopic correction of their VUR by subureteric injection of PPC or Dx/HA from Jan 2010 to April 2016. The injection technique was STING (subureteric), distal HIT (intraureteric),...
Source: Urology Journal - August 26, 2018 Category: Urology & Nephrology Authors: Alizadeh F, Omidi I, Haghdani S, Hatef Khorrami M, Izadpanahi MH, Mohammadi Sichani M Tags: Urol J Source Type: research

Evaluation of the intravesical ureters after failed endoscopic treatment of vesicoureteral reflux with dextranomer/hyaluronic acid in children via light and transmission electron microscopic analysis. A Matched Case-Control Study.
Abstract INTRODUCTION: The cytokine profile and the ultrastructural changes of refluxing ureterovesical junctions(UVJs) of children treated with failed dextranomer/hyaluronic-acid (Dx/HA) injections were investigated using immunohistochemical methods and transmission electron microscopy(TEM). PATIENTS AND METHODS: Eighteen children who underwent ureteroneocystostomy were included the study. The smooth muscle arrangement of the ureteral wall, transforming growth factor-?(TGF-?1),vascular-endothelial-growth factor(VEGF) and CD34 were evaluated immunohistochemically, and the results were compared with 10 age-mat...
Source: Urology Journal - August 26, 2018 Category: Urology & Nephrology Authors: Izol V, Kuyucu Y, Acikalin A, Deger M, Aridogan IA, Polat S, Satar N Tags: Urol J Source Type: research

Giant gastric lipoma successfully removed by endoscopic submucosal dissection: case report and systematic review.
CONCLUSION: Our findings support the conclusion that ESD may be a safe alternative to conventional surgery for removal of large symptomatic gastric lipomas. PMID: 30134740 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - August 25, 2018 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

A proposed scheme to cope with comorbidities in asthma
Publication date: Available online 25 August 2018Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Luane Marques de Mello, Álvaro A. CruzAbstractThe prevalence of non-communicable chronic diseases has been on the rise and the co-occurrence of morbidities is becoming more common. Multimorbidities are found more frequently among women, those with a history of mental disorders, lower level of schooling, and unfavorable socioeconomic condition. Physical inactivity, smoking and obesity are also associated with multimorbidities. Its occurrence is directly related to the age, affecting the majority of the individ...
Source: Pulmonary Pharmacology and Therapeutics - August 25, 2018 Category: Respiratory Medicine Source Type: research

Circumferential distribution and clinical characteristics of esophageal cancer in lower esophagus: differences related to histological subtype
ConclusionOur results showed no circumferential predilection for ESCC in the lower esophagus, suggesting that development of this type of lesion may be less affected by gastroesophageal reflux. In addition, EAC at the EGJ was frequently found on the right-anterior wall irrespective of BE length. (Source: Esophagus)
Source: Esophagus - August 25, 2018 Category: Gastroenterology Source Type: research

Gastroesophageal reflux disease: from heartburn to Barrett esophagus, and beyond
(Source: Updates in Surgery)
Source: Updates in Surgery - August 24, 2018 Category: Surgery Source Type: research

Gastroesophageal reflux disease and morbid obesity: evaluation and treatment
AbstractGastroesophageal reflux disease (GERD) is markedly increased among the obese population being recognized as one of the many obesity-related comorbidities. This concept should raise awareness, making physicians investigate more profoundly about this disease in this kind of patients. Currently, bariatric surgery is considered the gold standard treatment for morbid obesity. However, not all the operations are appropriate for the treatment of GERD and not all the patients are willing to receive bariatric surgery for the treatment of GERD. Even though sleeve gastrectomy has emerged as a suitable treatment option for mor...
Source: Updates in Surgery - August 24, 2018 Category: Surgery Source Type: research

Laryngopharyngeal Reflux and GERD: Correlation Between Reflux Symptom Index and Reflux Finding Score
This study also illustrates the importance of PPI therapy in LPR patients with no evidence of GERD. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - August 23, 2018 Category: ENT & OMF Source Type: research

Haiti's rural Central Plateau: Baseline data from mobile health clinics.
This study provides valuable baseline health data for those providing medical care in the Central Plateau of Haiti. Effective health care targets include intestinal parasitic infections and malnourishment for children; hypertension and GERD for adults. PMID: 30122678 [PubMed - in process] (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - August 22, 2018 Category: International Medicine & Public Health Authors: Crenshaw M, Gribbin M, Qasmieh S, Heil J, Ward C, Kariya S, Kern J Tags: J Health Care Poor Underserved Source Type: research

[Minimally invasive robot-assisted gastric bypass after open Mason reduction gastroplasty].
CONCLUSION: This preliminary experience suggests that robotic revisional surgery can be performed safely even after complicated bariatric operations. PMID: 30135966 [PubMed - as supplied by publisher] (Source: Der Chirurg)
Source: Der Chirurg - August 22, 2018 Category: Surgery Authors: Hesse U, Lenz J, Thumfart L, Stein H Tags: Chirurg Source Type: research

[EndoStim ® treatment-a new minimally invasive technology in antireflux surgery].
CONCLUSION: Electrical neuromodulation is a technique that successfully provides patients with GERD with control of their reflux symptoms. The technique requires interdisciplinary patient selection, comprehensive patient education, and comprehensive surgical training. The method is not free of postoperative problems. The electrical neuromodulation of the LES should therefore be used especially in centers with high expertise in reflux therapy. PMID: 30132169 [PubMed - as supplied by publisher] (Source: Der Chirurg)
Source: Der Chirurg - August 21, 2018 Category: Surgery Authors: Stephan D, Attwood S, Labenz J, Willeke F Tags: Chirurg Source Type: research

Antibiotics in Early Life and Allergic Disorders
To the Editor We read with interest the Mitre et al article describing associations between acid-suppressive medications, antibiotics, and subsequent pediatric allergic disease. Because histamine-2-receptor antagonists (H2RAs) are commonly prescribed for children with gastroesophageal reflux disease (GERD), the authors presented analyses of associations between H2RAs and allergic diseases, including food allergy, for all children, and only those dwho received a diagnosis of GERD. However, compared with any food allergy or individual foods among children given H2RAs, milk allergy has both a higher incidence and higher hazar...
Source: JAMA Pediatrics - August 20, 2018 Category: Pediatrics Source Type: research

Efficacy and safety of endoscopic dilatation in the management of esophageal strictures in children.
CONCLUSION: Endoscopic dilatation is a safe and effective intervention in the management of esophageal strictures in children, with minimal complications when conducted by experts. PMID: 30106416 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - August 16, 2018 Category: Middle East Health Tags: Saudi Med J Source Type: research

Esophageal Manometry for Diagnosing GERD
A 22-year-old man with a 10-year history of gastroesophageal reflux disease (GERD) –like symptoms and taking 20 mg/d of omeprazole had a normal esophagogastroduodenoscopy (EGD) and was diagnosed with achalasia following a high-resolution manometry (HRM) study. What would you do next? (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - August 16, 2018 Category: General Medicine Source Type: research

Vertical and Circumferential Localization of Esophageal Mucosal Breaks in Patients with Mild Reflux Esophagitis.
Conclusion Esophageal mucosal breaks occurring relatively near the esophagogastric junction mainly exist on the right anterior wall, whereas those farther from that junction tend to exist on the posterior wall of the esophagus. The circumferential location of esophageal mucosa highly exposed to refluxed gastric contents changes based on the distance from the esophagogastric junction. PMID: 30101941 [PubMed - as supplied by publisher] (Source: Internal Medicine)
Source: Internal Medicine - August 15, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Meta-Analysis of Gastroesophageal Reflux Disease and Idiopathic Pulmonary Fibrosis.
acute;, Lacasse Y Abstract BACKGROUND: The relationship between gastroesophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF) is controversial. Current guidelines recommend that clinicians use regular antacid treatment, while 2 recent meta-analyses of antacid therapy in IPF were inconclusive. Our objective was to examine the evidence regarding the association between GERD and IPF through a systematic review and a meta-analysis, with special reference to the methodological quality of the observational studies. METHODS: We searched Medline, Embase, Ovid and Web of Science (1966 - May 2018) for ...
Source: Chest - August 15, 2018 Category: Respiratory Medicine Authors: Bédard Méthot D, Leblanc É, Lacasse Y Tags: Chest Source Type: research

A Common Condition with an Uncommon Presentation
​BY ARJUN BHARAD​WAJ​ & AHMED RAZIUDDIN, MD​A 41-year-old man who recently immigrated from Africa came to the ED with abdominal pain. The patient primarily spoke Tigrinya, and an interpreter was used in taking a history. The patient's abdominal pain had started four hours earlier, which he described as squeezing or cramping mid-epigastric and umbilical pain. The pain did not change or radiate.He had also had three episodes of nonbloody emesis. This was a new problem for him, and he hadn't encountered anyone sick or with similar symptoms. His last bowel movement was the previous night, and no changes in bowel or...
Source: The Case Files - August 14, 2018 Category: Emergency Medicine Tags: Blog Posts Source Type: research

The added value of magnifying endoscopy in diagnosing patients with certain gastroesophageal reflux disease
ConclusionsMagnifying endoscopy reveals abnormalities that can be used as additional endoscopic diagnostic criteria of gastroesophageal reflux disease. (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - August 14, 2018 Category: Biomedical Science Source Type: research

Per-oral endoscopic myotomy in achalasia: Which way to go —anterior or posterior?
We read with great interest the article by Tan et  al1 wherein the authors have compared the efficacy and safety of per-oral endoscopic myotomy (POEM) by an anterior versus a posterior approach. The authors concluded that POEM is equally safe and effective when performed by an anterior or a posterior approach. In addition, the incidence of gastroe sophageal reflux disease (GERD) was equal in both groups (anterior, 26.7%; posterior, 33.3%). (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - August 14, 2018 Category: Gastroenterology Authors: Zaheer Nabi, Mohan Ramchandani, D. Nageshwar Reddy Tags: Letter to the Editor Source Type: research

Heat transfer and entropy generation of the nanofluid flow inside sinusoidal wavy channels
Publication date: 1 November 2018Source: Journal of Molecular Liquids, Volume 269Author(s): Reza Dormohammadi, Mahmood Farzaneh-Gord, Amir Ebrahimi-Moghadam, Mohammad Hossein AhmadiAbstractCorrugating channel walls is a way to enhance heat transfer in heat exchangers. In the current investigation, the entropy generation minimization approach has been employed to optimize heat transfer and fluid flow within a wavy channel. A numerical method has been built to compute entropy generation rate in a sinusoidal wavy-wall channel with copper-water (Cu-water) nanofluid flow. The governing equations have been discretized using fini...
Source: Journal of Molecular Liquids - August 14, 2018 Category: Molecular Biology Source Type: research

Gastroesophageal reflux in children with neurological impairment: a systematic review and meta-analysis
AbstractNeurologically impaired children (NIC) suffer severe gastroesophageal reflux (GER) with poor fundoplication outcome. Aims of the study were: (1) to determine the recurrence of GER after fundoplication in NIC; (2) to compare fundoplication versus gastro-jejunal tube feeding insertion (GJ) and fundoplication versus total esophagogastric dissociation (TEGD) in primarily treating GER in NIC. Using defined search strategy, two investigators identified all comparative studies reporting the mentioned procedures to primarily treat GER in NIC. The study was conducted under PRISMA guidelines. The meta-analysis was performed ...
Source: Pediatric Surgery International - August 13, 2018 Category: Surgery Source Type: research