#12 Proposed randomised controlled feasibility trial of a novel polyvinylideneflouride (PVDF) mesh (Dynamesh ®-HIATUS) cruroplasty versus suture-only repair of large hiatus hernia: the DYNAMIC Study (oral presentation)
Background: Gastro-oesophageal reflux disease (GORD) is a significant health problem affecting up to 25% of adults. Keyhole surgical treatment of chronic GORD has become an alternative to medical treatment over the past 20 years. However, patients with large hiatus hernias more than 5cm in size appear to have poorer results with recurrence in up to half of the patients. The use of mesh reinforcement has been considered to improve this, as this has been efficacious in other hernia repairs. However, with hiatal hernia repair there have been concerns about risks of mesh erosion and infection, and results to date have been equ...
Source: International Journal of Surgery - November 1, 2018 Category: Surgery Authors: S. Toh, B. Knight, C. Fogg, E. Baddesley, A. Higginson, R. Beable, S. Babu, E. Hawes, M. Moon, J. Shoebridge, P. Meredith, M. Amos-Lyons, P. May-Miller Source Type: research

Lymphocytic gastritis induced by pembrolizumab in a patient with metastatic melanoma
We present the case of a 44-year-old man with advanced melanoma and recurrent lung metastases who developed symptoms of dyspepsia and gastroesophageal reflux disease after 1 month of therapy with pembrolizumab. Gastric biopsy showed histologic features consistent with lymphocytic gastritis, which was absent on a biopsy 2 months before initiation of therapy. Lymphocytic infiltrates likely secondary to increased autoimmunity after use of immunotherapy have been observed in the colon; however, such histologic findings in the upper gastrointestinal tract have yet to be described. Here, we present a case of lymphocytic gastriti...
Source: Melanoma Research - October 31, 2018 Category: Cancer & Oncology Tags: SHORT COMMUNICATIONS Source Type: research

Can Freehand Elastosonography Be an Alternative to Renal Scintigraphy in Pediatric Vesicoureteral Reflux Cases?
Conclusion In this study, we could not find any significant difference in term of tissue tension values (ST and SI) measured by freehand elastosonography between renal units with and without scar formation in renal scan. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - October 31, 2018 Category: Surgery Authors: Karabulut, Bilge Bayram, Gulsah Oztorun, Can Ihsan Ozcift, Burak Tiryaki, Tu ğrul Hüseyin Tags: Original Article Source Type: research

ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats
This report offers a consensus opinion on the rational administration of GI protectants to dogs and cats, with an emphasis on proton pump inhibitors (PPIs), histamine type ‐2 receptor antagonists (H2RAs), misoprostol, and sucralfate. These medications decrease gastric acidity or promote mucosal protective mechanisms, transforming the management of dyspepsia, peptic ulceration, and gastroesophageal reflux disease. In contrast to guidelines that have been established in people for the optimal treatment of gastroduodenal ulcers and gastroesophageal reflux disease, effective clinical dosages of antisecretory drugs have not b...
Source: Journal of Veterinary Internal Medicine - October 31, 2018 Category: Veterinary Research Authors: Stanley L. Marks, Peter H. Kook, Mark G. Papich, M. Katherine Tolbert, Michael D. Willard Tags: CONSENSUS STATEMENT Source Type: research

Laparoscopic placement of the linx® system in management of severe reflux after sleeve gastrectomy
ConclusionThe LINX® system may be used as an alternative to RYGB conversion in managing refractory post-SG reflux. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - October 30, 2018 Category: Surgery Source Type: research

Endosheath ultrathin transnasal endoscopy is a cost-effective method for screening for Barrett ’s esophagus in patients with GERD symptoms
In this study, we determined the cost-utility of uTNE in a high-risk subgroup compared with no screening or screening with standard endoscopy (SE). (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - October 29, 2018 Category: Gastroenterology Authors: Judith Honing, Wietske Kievit, Jan Bookelaar, Yonne Peters, Prasad G. Iyer, Peter D. Siersema Source Type: research

The diagnostic value of GerdQ in subjects with atypical symptoms of gastro-esophageal reflux disease.
CONCLUSIONS: GerdQ has a diagnostic value in an unselected population presenting with typical and/or atypical symptoms of GERD, but a low sensitivity for diagnosis of GERDpH was found in subjects with predominant symptoms such as cough, dysphagia and globus. PMID: 30353750 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - October 27, 2018 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Pneumomediastinum as a complication of esophageal intramural pseudodiverticulosis.
We report esophageal intramural pseudodiverticulosis (EIPD) as a cause of dysphagia that is less known by physicians and it is rarely described in the literature. EIPD is characterized by multiple, segmental or diffuse, flask-like outpouchings in the esophageal wall corresponding to dilated and inflamed excretory ducts of the submucosal esophageal glands. The underlying etiology remains unclear. Esophageal strictures, esophageal candidiasis and gastroesophageal reflux disease are often associated. The diagnosis can be made by upper gastrointestinal endoscopy, but barium esophagography is the modality of choice. Complicatio...
Source: Acta Gastro-Enterologica Belgica - October 25, 2018 Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research

A Multifaceted Intervention to Reduce Pediatric Acid-Suppressant Prescriptions for Gastroesophageal Reflux: What Have We Learned?
Conclusion: This multifaceted implementation strategy did not lead to a significant difference in acid-suppressant prescriptions by tertiary care clinicians of whom the majority was familiar with the gastroesophageal reflux disease guideline. Future studies should clarify, which implementation strategies are most effective in reducing inappropriate prescribing of acid suppressants for children. Uniform registration of prescriptions and indications in a national database will enable monitoring of the intervention effect. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 25, 2018 Category: Gastroenterology Tags: Original Article: Gastroenterology Source Type: research

Early Infant Risk Factors for Pediatric Eosinophilic Esophagitis
Conclusions: Acid-blocking medications and antibiotics during infancy were associated with later diagnosis of EoE. Erythema toxicum neonatorum, an eosinophilic immune phenomenon, was strongly associated with EoE. Identifying early infant risk factors for EoE may help to risk stratify the need for endoscopy. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 25, 2018 Category: Gastroenterology Tags: Original Article: Gastroenterology: Eosinophilic GI Disease Source Type: research

Potent Acid Suppression with PPIs and P-CABs: What ’s New?
AbstractPurpose of the reviewAcid suppression treatment has revolutionized the management of the acid-related disorders since the introduction of the H2-receptor antagonists (H2-RAs) and the proton pump inhibitors (PPIs). However, there has been increasing identification of needs for improvement in antisecretory therapy, especially in gastroesophageal reflux disease (GERD), the eradication ofHelicobacter pylori (H. pylori), protection from aspirin (ASA) and non-steroidal inflammatory drug (NSAID) injury and the management of upper gastrointestinal (UGI) bleeding. There have also been increasing publications addressing safe...
Source: Current Treatment Options in Gastroenterology - October 25, 2018 Category: Gastroenterology Source Type: research

Comparative study of acid functionalization of carbon nanotube via ultrasonic and reflux mechanism
Publication date: October 2018Source: Journal of Environmental Chemical Engineering, Volume 6, Issue 5Author(s): Lau Yien Jun, N.M. Mubarak, Lau Sie Yon, Chua Han Bing, Mohammad Khalid, E.C. AbdullahAbstractMulti-walled carbon nanotubes (MWCNTs) have a great potential in wide applications due to their extraordinary physical, thermal and mechanical properties. However, the known shortcomings, such as hydrophobic nature, poor solubility and dispersibility in most solvents have impeded the technology to further develop. In the present study, various types of acid functionalized MWNCTs (f-MWCNTs) samples were prepared. The inv...
Source: Journal of Environmental Chemical Engineering - October 24, 2018 Category: Chemistry Source Type: research

Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study.
Conclusion: This cross-sectional study revealed that anxiety and depression levels were significantly higher in subjects with GERD (notably in the NERD) than in controls. PMID: 30347938 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 24, 2018 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Development and Psychometric Assessment of a Self-evaluation Questionnaire for Gastroesophageal Reflux Disease.
This study was conducted to develop an instrument and to determine of the definition of respondent for a patient reported outcomes to assess the efficacy of a treatment used for GERD treatment. Methods: A structural process has developed a self-evaluation questionnaire for GERD (SEQ-GERD); health-related quality of life questionnaire for GERD (GERD-QOL) was translated through cross-cultural validation. Two-week reproducibility was evaluated and construct validity was assessed by correlating the SEQ-GERD with the Patient Assessment of Gastrointestinal Disorders (PAGI-SYM), the reflux disease questionnaire (RDQ), and GER...
Source: Journal of Neurogastroenterology and Motility - October 24, 2018 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Pathophysiology of Potassium-competitive Acid Blocker-refractory Gastroesophageal Reflux and the Potential of Potassium-competitive Acid Blocker Test.
Conclusions: Intra-gastric pH and acid reflux were strongly suppressed by 20-mg vonoprazan. When patients with gastroesophageal reflux disease present symptoms after administration of 20-mg vonoprazan, the possibility of pathophysiologies other than acid reflux should be considered. PMID: 30347936 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 24, 2018 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The Changing Epidemiology of Gastroesophageal Reflux Disease: Are Patients Getting Younger?
Authors: Yamasaki T, Hemond C, Eisa M, Ganocy S, Fass R Abstract Background/Aims: Gastroesophageal reflux disease (GERD) is a common disease globally with increasing prevalence and consequently greater burden on the Healthcare system. Traditionally, GERD has been considered a disease of middle-aged and older people. Since risk factors for GERD affect a growing number of the adult population, concerns have been raised that increasingly younger people may develop GERD. We aim to determine if the proportion of younger patients has increased among the GERD population. Methods: The incidence of GERD as well as sever...
Source: Journal of Neurogastroenterology and Motility - October 24, 2018 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

It Is Time to Meet the Challenges of the Changing Epidemiology of Gastroesophageal Reflux Disease.
Authors: Kim GH PMID: 30347932 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - October 24, 2018 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

The effect of dietary carbohydrate on gastroesophageal reflux disease
ConclusionMore acid reflux symptoms are found after high carbohydrate diet. High carbohydrate diet could induce more acid reflux in low esophagus and more reflux symptoms in patients with gastroesophageal reflux disease. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - October 24, 2018 Category: General Medicine Source Type: research

An improved surgical procedure to establish a gastroesophageal reflux model with a high incidence of Barrett's esophagus in rats.
Authors: Wen H, Liu T, Liu H, Teng JH, Li SB Abstract Barrett's esophagus (BE) is a complication of gastroesophageal reflux disease and is a precursor lesion of esophageal adenocarcinoma. In existing BE models, the incidence of BE is typically low and induction is usually time consuming. In the present study, a gastroesophageal reflux model with a high incidence of BE in rats. Rats were divided into a model group and a sham operation group, and anesthetized with an inhalation anesthesia machine. Stomach-jejunal anastomosis (SJA) and esophagus-jejunal anastomosis (EJA) were simultaneously performed in the model grou...
Source: Experimental and Therapeutic Medicine - October 24, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Independent factors associated with the impact of gastroesophageal reflux disease on health-related quality of life.
Authors: Zatarain Valles A, Serrano Falcón B, Álvarez Sánchez Á, Rey Díaz-Rubio E Abstract BACKGROUND: although a number of factors have been associated with a deterioration in quality of life in gastroesophageal reflux disease, it is not known which has an independent influence. OBJECTIVE: to evaluate factors independently associated with the impact of gastroesophageal reflux disease on health-related quality of life. METHODS: a post-hoc analysis of a prospective cohort of patients diagnosed with gastroesophageal reflux disease was performed. The patients completed valida...
Source: Revista Espanola de Enfermedades Digestivas - October 24, 2018 Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research

Esophageal adenocarcinoma in Barrett’s esophagus after sleeve gastrectomy: Case report and literature review
Conclusion: Preoperative endoscopy should be performed in order to detect GERD, BE, and potential carcinomas of the upper gastrointestinal tract before undergoing bariatric surgery. The long-term monitoring after SG is essential. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - October 23, 2018 Category: Surgery Source Type: research

Gastroesophageal and Laryngopharyngeal Reflux Associated with Laryngeal Malignancy: A Systematic Review and Meta-Analysis
Gastric reflux could lead to chronic mucosal inflammation and contribute to development of laryngeal malignancies, although there is controversy over this association. We performed a systematic review and meta-analysis to assess this relationship and determine risk of laryngeal malignancy in patients with reflux disease. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 23, 2018 Category: Gastroenterology Authors: Sean M. Parsel, Eric L. Wu, Charles A. Riley, Edward D. McCoul Source Type: research

Gastroesophageal and Laryngopharyngeal Reflux Associated  With Laryngeal Malignancy: A Systematic Review and Meta-Analysis
Gastric reflux could lead to chronic mucosal inflammation and contribute to development of laryngeal malignancies, although there is controversy over this association. We performed a systematic review and meta-analysis to assess this relationship and determine the risk of laryngeal malignancy in patients with reflux disease. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 23, 2018 Category: Gastroenterology Authors: Sean M. Parsel, Eric L. Wu, Charles A. Riley, Edward D. McCoul Source Type: research

Persistent Dysphagia Rate After Antireflux Surgery is Similar for Nissen Fundoplication and Partial Fundoplication
This study aimed to determine risk factors for persistent postoperative dysphagia, specifically examining the type of fundoplication. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - October 23, 2018 Category: Surgery Authors: Kara Vande Walle, Luke M. Funk, Yiwei Xu, Kevin D. Davies, Jacob Greenberg, Amber Shada, Anne Lidor Tags: Gastrointestinal Source Type: research

Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder.
This study describes the development of a brief, parent-report screen that relies minimally upon the child's ability to report or localize pain for identifying children with ASD at risk for one of three common gastrointestinal disorders (functional constipation, functional diarrhea, and gastroesophageal reflux disease). In a clinical sample of children with ASD, this 17-item screen identified children having one or more of these disorders with a sensitivity of 84%, specificity of 43%, and a positive predictive value of 67%. If found to be valid in an independent sample of children with ASD, the screen will be useful in bot...
Source: Journal of Autism and Developmental Disorders - October 22, 2018 Category: Psychiatry Authors: Margolis KG, Buie TM, Turner JB, Silberman AE, Feldman JF, Murray KF, McSwiggan-Hardin M, Levy J, Bauman ML, Veenstra-VanderWeele J, Whitaker AH, Winter HS Tags: J Autism Dev Disord Source Type: research

Gastrointestinal Disorders in Peritoneal Dialysis Patients
Background: Gastrointestinal (GI) disorders in peritoneal dialysis (PD) patients are relatively understudied in the literature, even though they have a serious impact in the morbidity parameters and the quality of life for this group of patients. Various diagnostic tools have been used, including instrumental methods and questionnaires, invariably validated in comparative studies.Summary: The prevalence of GI disorders is very high in PD patients. Compared to the haemodialysis patients they present a higher prevalence of reflux, eating dysfunction, gastroesophageal reflux, intestinal obstruction or adhesions and abdominal ...
Source: American Journal of Nephrology - October 19, 2018 Category: Neurology Source Type: research

One-year outcomes in children with eosinophilic esophagitis
ConclusionsAbsence of symptoms does not indicate mucosal healing; therefore, patients should be followed up endoscopically. Additionally, despite restricted diet, nutritional status remains unaffected. Finally, patients with EoE can develop significant GERD even years after the EoE diagnosis. (Source: Esophagus)
Source: Esophagus - October 19, 2018 Category: Gastroenterology Source Type: research

Gastrointestinal Disorders in Peritoneal Dialysis Patients.
Abstract BACKGROUND: Gastrointestinal (GI) disorders in peritoneal dialysis (PD) patients are relatively understudied in the literature, even though they have a serious impact in the morbidity parameters and the quality of life for this group of patients. Various diagnostic tools have been used, including instrumental methods and questionnaires, invariably validated in comparative studies. SUMMARY: The prevalence of GI disorders is very high in PD patients. Compared to the haemodialysis patients they present a higher prevalence of reflux, eating dysfunction, gastroesophageal reflux, intestinal obstruction or ...
Source: American Journal of Nephrology - October 19, 2018 Category: Urology & Nephrology Authors: Kosmadakis G, Albaret J, da Costa Correia E, Somda F, Aguilera D Tags: Am J Nephrol Source Type: research

The Pregnant Patient: Managing Common Acute Medical Problems.
Abstract Women often see their primary care physicians for common acute conditions during pregnancy. These conditions may be caused by pregnancy (obstetric problems) or worsened by pregnancy (obstetrically aggravated problems), or they may require special consideration during pregnancy because of maternal or fetal risks (nonobstetric problems). Primary care physicians should know the differential diagnosis for common conditions during pregnancy and recognize the important findings of obstetric and urgent nonobstetric problems. The family physician can evaluate and treat most nonobstetric problems, although obstetr...
Source: American Family Physician - October 17, 2018 Category: Primary Care Authors: Gregory DS, Wu V, Tuladhar P Tags: Am Fam Physician Source Type: research

Clinical Characteristics and Outcomes of Patients With Post-Fundoplication Dysphagia
Dysphagia is a consequence of anti-reflux surgery (ARS) for gastroesophageal reflux disease (GERD). We studied patient management and symptomatic outcomes. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 17, 2018 Category: Gastroenterology Authors: Stephen Hasak, L. Michael Brunt, Dan Wang, C. Prakash Gyawali Source Type: research

Clinical Characteristics and Outcomes of Patients With Postfundoplication Dysphagia
Dysphagia is a consequence of antireflux surgery (ARS) for gastroesophageal reflux disease (GERD). We studied patient management and symptomatic outcomes. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - October 17, 2018 Category: Gastroenterology Authors: Stephen Hasak, L. Michael Brunt, Dan Wang, C. Prakash Gyawali Source Type: research

Adverse effects of proton pump inhibitors: fact or fake news?
Purpose of review The present review summarizes the past year's literature, both clinical and basic science, regarding potential adverse effects of proton pump inhibitors. Recent findings Proton pump inhibitors are amongst the most widely prescribed and overprescribed medications worldwide. Although generally considered well tolerated, epidemiologic studies mining large databases have reported a panoply of purported serious adverse effects associated with proton pump inhibitors, including chronic kidney disease, cognitive decline, myocardial infarction, stroke, bone fracture and even death. It should be noted that the...
Source: Current Opinion in Gastroenterology - October 16, 2018 Category: Gastroenterology Tags: STOMACH AND DUODENUM: Edited by Mitchell L. Schubert Source Type: research

Globus: Current Concepts and Dilemmas
Globus is an area of interest for many medical specialists including otorhinolaryngologists, gastroenterologist, allergists, and psychiatrists. It may be caused by an organic disease, but it is not uncommon that an underlying etiology remains unidentified even after a full workup has been performed. Patients who suffer from globus usually visit several physicians from different specialties without finding a solution for their symptoms. Identifying the underlying cause of globus is not always a simple task; therefore, structural or functional abnormalities of the thyroid, larynx, pharynx, and esophagus should be investigate...
Source: Journal of Clinical Gastroenterology - October 16, 2018 Category: Gastroenterology Tags: CLINICAL REVIEWS Source Type: research

Throat Clearing, Frequently Reported, But is it GERD Related?
Conclusion: Although TC is often considered a possible GERD-related symptom, we found a low probability of objective association. TC is not likely to be the only presenting symptom, and if it happens, it is unlikely to be associated with GERD. Perhaps, TC should not be considered as a GERD symptom, even as an atypical one. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - October 16, 2018 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Gastroesophageal Reflux Frequency, Severity, Age of Onset, Family History and Acid Suppressive Therapy Predict Barrett Esophagus in a Large Population
Conclusions: Severe and frequent GERD symptoms are strongly associated with increased risk of BE in the general population, especially in the absence of frequent PPI use. Among people with GERD, family history of BE and early age of symptom onset were stronger predictors of BE. These findings may improve identification of patients at highest risk for BE. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - October 16, 2018 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Risk Factors for the Development of Idiopathic Pulmonary Fibrosis: a Review
AbstractPurpose of ReviewIdiopathic pulmonary fibrosis (IPF) is an invariably progressive disease. Current treatment options simply slow disease progression, and better therapeutic options are needed. We aimed to review an emerging literature on risk factors associated with the development of IPF.Recent FindingsThere is increasing data to support the role of intrinsic risk factors (e.g., genetics, aging, sex, lung microbiome), comorbidities (e.g., gastroesophageal reflux, obstructive sleep apnea, diabetes mellitus, herpes virus infection), and extrinsic risk factors (e.g., cigarette smoking, environmental exposures, air po...
Source: Current Respiratory Care Reports - October 16, 2018 Category: Respiratory Medicine Source Type: research

American Gastroenterological Association Institute Technical Review on the Medical Management of Opioid-Induced Constipation
Opioid medications are some of the most commonly prescribed medications for acute and chronic pain in the United States. In 2016, nearly 92 million US adults, or approximately 38% of the population, were prescribed opioids, according to results from the National Survey on Drug Use and Health.1 As a result of the widespread use of opioids, the prevalence of opioid-related adverse effects has increased markedly. Gastrointestinal (GI) side effects, such as nausea, vomiting, gastroesophageal reflux, gastroparesis, anorexia, bloating, abdominal spasms, and constipation, are  common and collectively referred to as opioid-in...
Source: Gastroenterology - October 16, 2018 Category: Gastroenterology Authors: Brian Hanson, Shazia Mehmood Siddique, Yolanda Scarlett, Shahnaz Sultan, American Gastroenterological Association Institute Clinical Guidelines Committee Tags: AGA Section Source Type: research

Some of the effective factors in the pathogenesis of gastro-oesophageal reflux disease.
Abstract Oesophageal adenocarcinoma is one of the most fatal tumours to affect the digestive tract and is the eighth most common malignancy worldwide. Gastro-oesophageal reflux has an important role in the incidence of adenocarcinoma of the oesophagus. Gastro-oesophageal reflux disease (GERD) is a multifactorial, acid-peptic disorder that results from the reflux of noxious material from the stomach into the oesophagus. The refluxed material causes the occurrence of oesophageal inflammation which creates a condition that is called reflux oesophagitis. The prevalence of this disease has increased dramatically in rec...
Source: J Cell Mol Med - October 15, 2018 Category: Molecular Biology Authors: Nejat Pish-Kenari F, Qujeq D, Maghsoudi H Tags: J Cell Mol Med Source Type: research

Retraction: Randomised clinical trial: The clinical efficacy and safety of an alginate ‐antacid (Gaviscon Double Action) versus placebo, for decreasing upper gastrointestinal symptoms in symptomatic gastroesophageal reflux disease (GERD) in China by J. Sun, C. Yang, H. Zhao, P. Zheng, J. Wilkinson, B. Ng, Y. Yuan. Aliment Pharmacol Ther. 2015;42:845‐854.
Alimentary Pharmacology&Therapeutics,Volume 48, Issue 9, Page 1039-1039, November 2018. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - October 15, 2018 Category: Drugs & Pharmacology Source Type: research

Esophageal adenocarcinoma in Barrett's esophagus after sleeve gastrectomy: Case report and literature review
Conclusion: Preoperative endoscopy should be performed in order to detect GERD, BE, and potential carcinomas of the upper gastrointestinal tract before undergoing bariatric surgery. The long-term monitoring after SG is essential. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - October 13, 2018 Category: Surgery Source Type: research

KAAACI Evidence-Based Clinical Practice Guidelines for Chronic Cough in Adults and Children in Korea.
Authors: Song DJ, Song WJ, Kwon JW, Kim GW, Kim MA, Kim MY, Kim MH, Kim SH, Kim SH, Kim SH, Kim ST, Kim SH, Kim JK, Kim JH, Kim HJ, Kim HB, Park KH, Yoon JK, Lee BJ, Lee SE, Lee YM, Lee YJ, Lim KH, Jeon YH, Jo EJ, Jee YK, Jin HJ, Choi SH, Hur GY, Cho SH, Kim SH, Lim DH Abstract Chronic cough is common in the community and causes significant morbidity. Several factors may underlie this problem, but comorbid conditions located at sensory nerve endings that regulate the cough reflex, including rhinitis, rhinosinusitis, asthma, eosinophilic bronchitis, and gastroesophageal reflux disease, are considered important. Howe...
Source: Allergy, Asthma and Immunology Research - October 13, 2018 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

The Influence of Antireflux Surgery on Esophageal Cancer Risk in England: National Population-based Cohort Study
Conclusion: Antireflux surgery may be associated with a reduced risk of esophageal cancer risk, however it remains primarily an operation for symptomatic relief. (Source: Annals of Surgery)
Source: Annals of Surgery - October 13, 2018 Category: Surgery Tags: ESA Papers Source Type: research

Nocturnal gastroesophageal reflux increases the risk of daytime sleepiness in women
Daytime sleepiness is common in women and has negative health effects. Nocturnal gastroesophageal reflux (nGER) and snoring are risk factors for daytime sleepiness, but the effect of their interaction remains unknown. The aim of this study was to examine how nGER and snoring combined affected daytime sleepiness and involuntary falling asleep in women. (Source: Sleep Medicine)
Source: Sleep Medicine - October 13, 2018 Category: Sleep Medicine Authors: Shadi Amid H ägg, Össur I. Emilsson, Karl Franklin, Christer Janson, Eva Lindberg Tags: Original Article Source Type: research

Obesity and increased risk of esophageal adenocarcinoma.
Authors: Elliott JA, Donohoe CL, Reynolds JV Abstract There has been a substantial increase in the incidence of esophageal adenocarcinoma over the past 40 years. Meta-analyses of large prospective cohorts and population-based case-control studies demonstrate consistent associations between obesity and the development of adenocarcinoma of the esophagus and esophago-gastric junction, with an approximate doubling of risk of esophageal adenocarcinoma among patients who are obese, and an almost five-fold increased risk among those with BMI>40 kg/m2. The pathologic precursor, specialized intestinal metaplasia in Barre...
Source: Expert Review of Endocrinology and Metabolism - October 13, 2018 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons
Publication date: Available online 11 October 2018Source: NeuronAuthor(s): Brie Wamsley, Xavier Hubert Jaglin, Emilia Favuzzi, Giulia Quattrocolo, Maximiliano José Nigro, Nusrath Yusuf, Alireza Khodadadi-Jamayran, Bernardo Rudy, Gord FishellSummaryCortical interneurons display a remarkable diversity in their morphology, physiological properties, and connectivity. Elucidating the molecular determinants underlying this heterogeneity is essential for understanding interneuron development and function. We discovered that alternative splicing differentially regulates the integration of somatostatin- and parvalbumin-expre...
Source: Neuron - October 12, 2018 Category: Neuroscience Source Type: research

Gastroesophageal Reflux Disease in Idiopathic Pulmonary Fibrosis: Uncertainties and Controversies
The mechanisms of idiopathic pulmonary fibrosis (IPF), a rare, devastating disease with a median survival of 3 –5 years, are not fully understood. Gastroesophageal reflux disease (GERD) is a frequent comorbidity encountered in IPF. Hypothetically, GERD-associated microaspiration may lead to persistent inflammation impairing lung infrastructure, thereby possibly accelerating the progression of IPF. IPF may increase intrathoracic pressure, which can aggravate GERD and vice versa. On the basis of the possible beneficial effects of antireflux or antacid therapy on lung function, acute exacerbation, and survival, the rece...
Source: Respiration - October 11, 2018 Category: Respiratory Medicine Source Type: research

The Effects of Esophageal Acidification on Esophageal Reflexes Controlling the Upper Esophageal Sphincter.
Abstract The aim of this study was to determine the effects of esophageal acid exposure on esophago-UES relaxation (EURR) and contractile (EUCR) reflexes. Cats, decerebrate (N=27) or chronic (N=4), were implanted with EMG electrodes on pharynx, larynx and esophagus. The esophagus was infused with either NaCl (0.9%) or HCl (0.1 N). The EUCR was activated by balloon distension in acute cats and slow air injection in chronic cats, and the EURR was activated by rapid air injection in both sets of cats. We found that NaCl infused for 15 or 30 minutes had no effect on EUCR or EURR in acute cats. HCl infused for 15, 30 o...
Source: Am J Physiol Gastroi... - October 11, 2018 Category: Gastroenterology Authors: Lang IM, Medda BK, Shaker R Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Minimally Invasive Intragastric Approach to Gastroesophageal Junction Pathology
ConclusionsResection of selected intramural GEJ pathology using a minimally invasive trans-gastric approach can be performed safely with acceptable morbidity and good long-term results. The approach allows preservation of the LES and vagi, a potential advantage compared to other surgical alternatives to resection in this region. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 10, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research

Negative payoffs of upper gastrointestinal endoscopy in patients admitted under observation status.
CONCLUSIONS: Upper gastrointestinal endoscopy in patients with atypical chest pain of GI origin as an initial step is a significant healthcare burden and contradicts the currently recommended High Value Care recommendations. Our study delineates this large negative financial impact when performing upper endoscopies under observation status. Such patients should be started on an empirical trial of PPI, and endoscopy should be reserved for patients whose symptoms are unresponsive to PPIs or have alarm features. PMID: 30293414 [PubMed - as supplied by publisher] (Source: Minerva Gastroenterologica e Dietologica)
Source: Minerva Gastroenterologica e Dietologica - October 10, 2018 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Minimally Invasive Intragastric Approach to Gastroesophageal Junction Pathology.
CONCLUSIONS: Resection of selected intramural GEJ pathology using a minimally invasive trans-gastric approach can be performed safely with acceptable morbidity and good long-term results. The approach allows preservation of the LES and vagi, a potential advantage compared to other surgical alternatives to resection in this region. PMID: 30315795 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - October 10, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Villano AM, Lofthus A, Watson TJ, Haddad NG, Marshall MB Tags: Ann Thorac Surg Source Type: research