Esophageal schwannomas: A rarity beneath benign esophageal tumors a case report
ConclusionThe knowledge about a new case, impacts in obtaining more information about the clinical course and surgical treatment of this tumor. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - April 19, 2019 Category: Surgery Source Type: research

Laparoscopic Heller Myotomy: A Fundoplication Is Necessary to Control Gastroesophageal Reflux
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - April 19, 2019 Category: Surgery Authors: Marco Di Corpo Timothy M. Farrell Marco G. Patti Source Type: research

Laparoscopic Heller Myotomy: A Fundoplication Is Necessary to Control Gastroesophageal Reflux
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic and Advanced Surgical Techniques)
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - April 19, 2019 Category: Surgery Authors: Marco Di Corpo Timothy M. Farrell Marco G. Patti Source Type: research

Gastroesophageal reflux and serum biomarkers in systemic sclerosis ‐related interstitial lung disease. Reply
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2019 Category: Rheumatology Authors: Muriel Elhai, Anna Maria Hoffmann ‐Vold, Yannick Allanore Tags: Reply to Letter to the Editor Source Type: research

Revision of Sleeve Gastrectomy with Hiatal Repair with Gastropexy for Gastroesophageal Reflux Disease
ConclusionHiatal repair with gastropexy is an acceptable treatment option for GERD after LSG but not very effective because of partial remission of symptoms. (Source: Obesity Surgery)
Source: Obesity Surgery - April 17, 2019 Category: Surgery Source Type: research

Characteristics and Findings of Childhood Urinary Tract Infection in the Last Decade
Conclusions: First UTI in a group of Thai children occurred in approximately equal proportion in boys and girls but boys were younger at diagnosis. Kidney and urinary tract anomalies were detected in half of the children.Urol Int (Source: Urologia Internationalis)
Source: Urologia Internationalis - April 16, 2019 Category: Urology & Nephrology Source Type: research

Juvenile-onset mixed connective tissue disease associated with macrophage activation syndrome: A case with refractory Raynaud’s phenomenon
ConclusionMCTD may present with a myriad of rheumatic manifestations and in association with MAS the diagnosis and management may be challenging. Refractory Raynauds’ phenomenon may remarkably improve on transthoracic sympathectomy. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - April 16, 2019 Category: Rheumatology Source Type: research

Addition of the Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m to Prolonged and Moderate Exercise Training Enhanced Protection of the Rat Heart From Type-1 Diabetes
Bartolo Ferraro1,2, Maria Donniacuo3, Loredana Sodano3, Franca Ferraraccio4, Rosa Maisto3, Eliana Gulotta5, Gorizio Pieretti6, Michele D’Amico3*, Maria Consiglia Trotta3 and Barbara Rinaldi3 1Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University of Munich, Munich, Germany 2DZHK, Partner Site Munich Heart Alliance, Munich, Germany 3Department of Experimental Medicine, Pharmacology Division, University of Campania “L. Vanvitelli”, Naples, Italy 4Department of Clinical, Public and Preventive Medicine, University of Campania “L. Vanvitelli”, Naples, Italy 5Departm...
Source: Frontiers in Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Sleep Is Compromised in −12° Head Down Tilt Position
Sleep Is Compromised in −12° Head Down Tilt Position Alessa L. Boschert1*, David Elmenhorst2,3, Peter Gauger1, Zhili Li4, Maria T. Garcia-Gutierrez5, Darius Gerlach1, Bernd Johannes1, Jochen Zange1, Andreas Bauer2,6 and Jörn Rittweger1,7 1Department of Muscle and Bone Metabolism, German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany 2Forschungszentrum Jülich, Institute of Neuroscience and Medicine (INM-2), Jülich, Germany 3Division of Medical Psychology, University of Bonn, Bonn, Germany 4State Key Laboratory of Space Medicine Fundamentals and Application, China ...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release
Alyce M. Martin1, Emily W. Sun1, Geraint B. Rogers2,3 and Damien J. Keating1,4* 1Molecular and Cellular Physiology Laboratory, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia 2Microbiome Research Laboratory, Flinders University, Adelaide, SA, Australia 3Infection and Immunity, South Australian Health and Medical Research Institute, Adelaide, SA, Australia 4Nutrition and Metabolism, South Australian Health and Medical Research Institute, Adelaide, SA, Australia The microbial community of the gut conveys significant benefits to host physiology. A clear relationship has now bee...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

History of gastroesophageal reflux disease in patients with suspected coronary artery disease
AbstractIt is well known that patients with gastroesophageal reflux disease (GERD) experience GERD-related chest pain, but little is known about the relationship between GERD and coronary artery disease (CAD). We evaluated medical history of GERD in patients with suspected CAD and its association with types of CAD. We enrolled 236 patients who underwent coronary angiography (CAG). We assessed past medical history of each patient, making note of esophageal or stomach diseases such as GERD including reflux esophagitis and non-erosive reflux disease. The patients were divided into the following three subgroups based on the CA...
Source: Heart and Vessels - April 16, 2019 Category: Cardiology Source Type: research

Higher clinical suspicion is needed for prompt diagnosis of esophageal adenocarcinoma in young patients
Esophageal cancer is considered a disease of the elderly. Although the incidence of esophageal adenocarcinoma in young patients is increasing, guidelines for endoscopic evaluation of gastroesophageal reflux disease and Barrett ’s esophagus include age as a cutoff. There is a paucity of data on the presentation and treatment of esophageal cancer in young patients. Most studies are limited by small sample sizes and conflicting findings are reported regarding delayed diagnosis and survival compared to older patients. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 16, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Tamar Nobel, Michael Curry, Renee Gennarelli, David Jones, Daniela Molena Source Type: research

Chronic cough and gastroesophageal reflux in children - CHEST Guideline and Expert Panel Report.
CONCLUSION: The panelists endorsed that: (1) treatment(s) for GERD should not be used when there are no clinical features of GERD and; (2) pediatric GERD guidelines should be used to guide treatment and investigations. PMID: 31002783 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 16, 2019 Category: Respiratory Medicine Authors: Chang AB, Oppenheimer JJ, Kahrilas PJ, Kantar A, Rubin BK, Weinberger M, Irwin RS, CHEST Expert Cough Panel Tags: Chest Source Type: research

The Rationale and Efficacy of Primary and Secondary Prevention in Adenocarcinomas of the Upper Gastrointestinal Tract
While the primary risk factor for oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett ’s oesophagus (BO) is gastro-oesophageal reflux, the infection withHelicobacter pylori (H. pylori) is the dominant risk factor for gastric cancer. Reduction of reflux by dietary measures and proton pump inhibitors has some merits in OAC prevention, and the chemopreventive effect of Aspirin and statins is being widely investigated; however, improved outcome in OAC occurs primarily as the result of secondary prevention. Early detection of neoplastic lesions in Barrett ’s metaplasia can be achieved by surveillance e...
Source: Digestive Diseases - April 15, 2019 Category: Gastroenterology Source Type: research

High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett ’s Esophagus via IL8 and Alterations to the Gut Microbiome
Barrett ’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased abdominal pressure and gastroesophageal reflux disease, although this pathogenic mechanism has not been proven. We investigated whether environme ntal or dietary factors associated with obesity contribute to progression of BE to EAC in mice. (Source: Gastroenterology)
Source: Gastroenterology - April 15, 2019 Category: Gastroenterology Authors: Natasha Stephens M ünch, Hsin-Yu Fang, Jonas Ingermann, H. Carlo Maurer, Akanksha Anand, Victoria Kellner, Vincenz Sahm, Maria Wiethaler, Theresa Baumeister, Frederik Wein, Henrik Einwächter, Florian Bolze, Martin Klingenspor, Dirk Haller, Maria Kavanag Source Type: research

High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett ’s Esophagus via Interleukin 8 and Alterations to the Gut Microbiome
Barrett ’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased abdominal pressure and gastroesophageal reflux disease, although this pathogenic mechanism has not been proven. We investigated whether environme ntal or dietary factors associated with obesity contribute to the progression of BE to EAC in mice. (Source: Gastroenterology)
Source: Gastroenterology - April 15, 2019 Category: Gastroenterology Authors: Natasha Stephens M ünch, Hsin-Yu Fang, Jonas Ingermann, H. Carlo Maurer, Akanksha Anand, Victoria Kellner, Vincenz Sahm, Maria Wiethaler, Theresa Baumeister, Frederik Wein, Henrik Einwächter, Florian Bolze, Martin Klingenspor, Dirk Haller, Maria Kavanag Tags: Basic and Translational —Alimentary Tract Source Type: research

Tracer-free liquid – vapor imaging using lifetime-filtered planar laser-induced fluorescence
The separation of liquid phase and vapor phase laser-induced fluorescence (LIF) signals using tracer species suffers from uncertainties in tracer – fuel coevaporation, as well as a disparity in liquid and vapor signals. This work demonstrates the use of a simple technique, referred to as ... (Source: Optics Letters)
Source: Optics Letters - April 14, 2019 Category: Physics Authors: Alber Douglawi Anthony McMaster Megan E. Paciaroni James B. Michael Benjamin R. Halls James R. Gord Terrence R. Meyer Source Type: research

Foregut Function Before and After Lung Transplant
Esophageal dysmotility and gastroesophageal reflux disease (GERD) are common in patients with advanced lung disease, and can potentially affect outcomes of lung transplant (LTx); however, the effects of LTx on foregut function remain unknown. We assessed foregut function before and after bilateral LTx. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Takahiro Masuda, Sumeet K. Mittal, Bal ázs Kovács, Michael A. Smith, Rajat Walia, Jasmine L. Huang, Ross M. Bremner Source Type: research

A novel endoloop pretest to treat severe gastroesophageal reflux disease symptoms before anti-reflux mucosectomy
Endoscopy DOI: 10.1055/a-0861-9849 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - April 12, 2019 Category: Gastroenterology Authors: Min, Min Liu, Yan Tags: E-Videos Source Type: research

Preliminary optimization of acupuncture regimen at Nèiguān (PC 6) for gastroesophageal reflux disease
ConclusionIn the observation of five factors and two levels, the optimal regimen of acupuncture for GERD includes reducing technique by rotating needle at PC 6, the time of rotating needle for 60 s, Zúsānlĭ (足三里 ST 36) and Tàichōng (太冲 LR 3) as the supplementary acupoints, needle retention for 30 min and treatment interval of 24 h. (Source: World Journal of Acupuncture Moxibustion)
Source: World Journal of Acupuncture Moxibustion - April 11, 2019 Category: Complementary Medicine Source Type: research

Evaluation of Baseline Impedance During Water-perfused High Resolution Impedance Manometry in Patients With Symptomatic GERD
Goals: We aimed to investigate the hypothesis whether baseline impedance measured during water-perfused high resolution impedance manometry (HRIM) can help discriminate patients with reflux symptoms from the controls and predict the response to the proton pump inhibitors (PPIs). Background/Aim: Baseline impedance measured during solid-state HRIM can reliably discriminate patients with gastroesophageal reflux disease (GERD) from controls. Study: We enrolled consecutive patients with typical reflux symptoms and healthy controls for the measurement of baseline impedance during the landmark period of HRIM. All patients...
Source: Journal of Clinical Gastroenterology - April 10, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Evaluation of Important Analytical Parameters of the Peptest Immunoassay that Limit its Use in Diagnosing Gastroesophageal Reflux Disease
Conclusions: The Peptest assay’s sensitivity and specificity is low, the results are highly variable and it should not be used as a near-patient diagnostic method in primary care. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 10, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Functional Gastrointestinal Disease in Autism Spectrum Disorder: A Retrospective Descriptive Study in a Clinical Sample
Conclusions: Almost one-third of ASD patients in our sample had at least one fGID. The presence of fGID was associated with ID, sleep problems and with behavioral problems (as measured by the prescription of psychotropic drugs). This subsample of ASD patients with fGID deserves particular attention in future research projects, focusing on specific phenotypic characteristics and overlapping biological markers that may underlie both pathologies. Introduction Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by impairments in social communication and restricted, repetitive patterns ...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Outcomes of One Anastomosis Gastric Bypass in the IFSO Middle East North Africa (MENA) Region
AbstractIntroductionSince it was first described in 2001, the one anastomosis gastric bypass (OAGB) has been gaining popularity in the Middle East region and worldwide. We designed a survey to evaluate the trends, techniques, and outcomes of OAGB in our region.MethodsA questionnaire to study OAGB was sent to the members of the IFSO MENA chapter.ResultsOne-hundred and forty-eight surgeons (74%) responded. Forty-six percent of all respondents (64 surgeons) performed OAGB routinely. The most commonly performed procedures were the laparoscopic sleeve gastrostomy (LSG), followed by OAGB, and then Roux-en-Y (RYGB). Of the surgeo...
Source: Obesity Surgery - April 10, 2019 Category: Surgery Source Type: research

Definition of excessive daytime sleepiness in the general population: Feeling sleepy relates better to sleep-related symptoms and quality of life than the Epworth Sleepiness Scale score. Results from an epidemiological study.
Abstract Many different subjective tools are being used to measure excessive daytime sleepiness (EDS) but the most widely used is the Epworth Sleepiness Scale (ESS). However, it is unclear if using the ESS is adequate on its own when assessing EDS. The aim of this study was to estimate the characteristics and prevalence of EDS using the ESS and the Basic Nordic Sleep Questionnaire (BNSQ) in general population samples. Participants aged 40 years and older answered questions about sleepiness, health, sleep-related symptoms and quality of life. Two groups were defined as suffering from EDS: those who scored>1...
Source: Journal of Sleep Research - April 10, 2019 Category: Sleep Medicine Authors: Thorarinsdottir EH, Bjornsdottir E, Benediktsdottir B, Janson C, Gislason T, Aspelund T, Kuna ST, Pack AI, Arnardottir ES Tags: J Sleep Res Source Type: research

Magnesium alginate in children with uncontrolled asthma.
Authors: Miraglia Del Giudice M, Indolfi C, Ciprandi G, Decimo F, Campana G, Umano GR, Giannetti E, Maglione M Abstract Gastroesophageal reflux disease (GERD) may be frequently associated with asthma in children and may affect asthma control. Proton pump inhibitors (PPI) are commonly prescribed in asthmatic children, despite uncertain efficacy on respiratory symptoms and risk of relevant adverse effects. PMID: 30945510 [PubMed - as supplied by publisher] (Source: Journal of Biological Regulators and Homeostatic Agents)
Source: Journal of Biological Regulators and Homeostatic Agents - April 6, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research

Esophageal Impedance-pH Monitoring and Pharyngeal pH Monitoring in the Diagnosis of Extraesophageal Reflux in Children.
Authors: Plocek A, Gębora-Kowalska B, Białek J, Fendler W, Toporowska-Kowalska E Abstract Various clinical symptoms are attributed to extraesophageal reflux disease (EERD). Multichannel intraluminal impedance-pH monitoring (MII-pH) is considered to correlate symptoms with acid and nonacid gastroesophageal reflux (GER) events. Pharyngeal pH monitoring (Dx-pH) is considered to correlate the decrease in the pH level in the oropharynx with reported symptoms and to diagnose supraesophageal reflux. We aimed to assess the correlation between acid reflux episodes recorded by Dx-pH and GER detected via MII-pH in children ...
Source: Gastroenterology Research and Practice - April 6, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

A Prospective Randomized Trial to Assess the Antireflux Effect of Antireflux Mucosectomy in the Porcine Model.
Conclusion: Our study demonstrated the potential antireflux effect of ARMS. We also recommend the 2/3 circumference resection of mucosa at 3 cm distance from the GEJ. PMID: 30944560 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - April 6, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Preliminary optimization of acupuncture regimen at Nèiguān(PC 6) for gastroesophageal reflux disease
ConclusionIn the observation of five factors and two levels, the optimal regimen of acupuncture for GERD includes reducing technique by rotating needle at PC 6, the time of rotating needle for 60 s, Zúsānlĭ (足三里 ST 36) and Tàichōng (太冲 LR 3) as the supplementary acupoints, needle retention for 30 min and treatment interval of 24 h. (Source: World Journal of Acupuncture Moxibustion)
Source: World Journal of Acupuncture Moxibustion - April 6, 2019 Category: Complementary Medicine Source Type: research

IJERPH, Vol. 16, Pages 1229: The Association between Health Conditions in World Trade Center Responders and Sleep-Related Quality of Life and Sleep Complaints
Conclusions: Sleep complaints are common and related to several health conditions seen in WTC responders. Initial interventions in symptomatic patients with both OSA and comorbid conditions may need to be directed at sleep duration, insomnia or the comorbid condition itself, in combination with intervention for OSA. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - April 6, 2019 Category: Environmental Health Authors: Indu Ayappa Yingfeng Chen Nisha Bagchi Haley Sanders Kathleen Black Akosua Twumasi David M. Rapoport Shou-En Lu Jag Sunderram Tags: Article Source Type: research

[Tooth Erosions Associated with Gastroesophageal Reflux: Cause, Prevention and Restorative Therapy].
Abstract Tooth Erosions Associated with Gastroesophageal Reflux: Cause, Prevention and Restorative Therapy Abstract. Dental erosions are caused by the recurring contact of solutions which are unsaturated in tooth minerals,ith hard tooth substances. This initially leads to softening and later to an irreversible loss of hard tooth substance. Erosion is observed particularly with excessive consumption of acidic foods (e.g. soft drinks or citrus fruits) but also in connection with gastrointestinal (gastroesophageal reflux disease) or psychosomatic diseases (anorexia nervosa or bulimia nervosa). The aim of this article...
Source: Praxis - April 5, 2019 Category: General Medicine Authors: Wegehaupt FJ, Attin T Tags: Praxis (Bern 1994) Source Type: research

Jackhammer Esophagus: From Manometric Diagnosis to Clinical Presentation.
Conclusions and Inferences: Jackhammer esophagus represents 3% of the HRM diagnoses in this study, with a significant female preponderance. In more than two-thirds of cases, the clinical presentation of Jackhammer esophagus is dysphagia. PMID: 30941328 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - April 5, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Identification and structural characterization of stress degradation products of omeprazole using Q-TOF-LC-ESI-MS/MS and NMR experiments: Evaluation of toxicity of degradation products
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ00932A, PaperShankar G, Roshan M Borkar, Suresh U, Marumudi Kanakaraju, Ganji Saicharan, Sunil Misra, Srinivas R. Omeprazole (OMP), a prototype proton pump inhibitor used for the treatment of peptic ulcers and gastroesophageal reflux disease(GERD), was subjected to forced degradation studies as per ICH guidelines Q1A (R2).... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 5, 2019 Category: Chemistry Authors: Shankar G Source Type: research

Exam 1: Gastroesophageal and Laryngopharyngeal Reflux Associated With Laryngeal Malignancy: A Systematic Review and Meta-analysis
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - April 5, 2019 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activity Source Type: research

Healthcare spending and utilization following antireflux surgery: examining costs and reasons for readmission
ConclusionThe majority of patients undergoing ARS do not require additional care within 90  days of surgery. Patients who are readmitted accrue costs that almost double the overall cost of care compared to the initial hospitalization. Measures to attenuate potentially preventable readmissions after ARS may reduce healthcare utilization in this patient population. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 5, 2019 Category: Surgery Source Type: research

Gastro-oesophageal reflux disease and hiatus hernia
Gastro-oesophageal reflux disease (GORD) is a common disorder with an increasing prevalence in th UK. The presence of a hiatus hernia is the strongest risk factor for developing GORD, although not essential. The most common symptoms experienced by patients with GORD are heartburn and acid regurgitation. Diagnosis of GORD is usually made from the clinical history. Endoscopy and ambulatory pH monitoring are adjunctive tests that can influence management decisions. The main goals of treatment are symptom control and the prevention of complications such as Barrett's oesophagus and peptic stricture. (Source: Medicine)
Source: Medicine - April 5, 2019 Category: Internal Medicine Authors: Hannah Cheston, Philip Woodland Tags: Mouth and oesophagus Source Type: research

Conversion of Sleeve Gastrectomy to One Anastomosis Gastric Bypass for Weight Loss Failure
ConclusionThis study shows that the conversion of SG to OAGB is feasible and safe allowing significant weight loss and improvement in comorbidities. Weight loss seems comparable between the 150-cm and 200-cm BPL. (Source: Obesity Surgery)
Source: Obesity Surgery - April 4, 2019 Category: Surgery Source Type: research

Laparoscopic antireflux surgery (LARS) is highly effective in the treatment of select patients with chronic cough
We present the largest single-center study to date of surgical and quality-of-life outcomes among patients treated with laparoscopic antireflux surgery for reflux-associated chronic cough. Extraesophageal manifestations of chronic gastroesophageal reflux are increasingly recognized, among which chronic cough may substantially compromise patient quality of life. Although the benefits of antireflux surgery are well documented in patients with typical symptoms of gastroesophageal reflux disease, less is known about the short-term impact of antireflux surgery on associated chronic cough. (Source: Surgery)
Source: Surgery - April 4, 2019 Category: Surgery Authors: Adrian Park, Adam S. Weltz, Zachary Sanford, Alex Addo, H. Reza Zahiri Source Type: research

Bronchodilators in subjects with asthma-related comorbidities
Asthma is often associated with different comorbidities such as cardiovascular diseases, depression, diabetes mellitus, dyslipidaemia, osteoporosis, rhinosinusitis and mainly gastro-oesophageal reflux disease and allergic rhinitis. Although bronchodilators play an important role in the treatment of asthma, there is no overall description of their impact on comorbid asthma, regardless of whether favourable or negative. This narrative review examines the potential effects of bronchodilators on comorbidities of asthma. (Source: Respiratory Medicine)
Source: Respiratory Medicine - April 3, 2019 Category: Respiratory Medicine Authors: Mario Cazzola, Paola Rogliani, Luigino Calzetta, Maria Gabriella Matera Tags: Review article Source Type: research

Barrett's oesophagus and oesophageal adenocarcinoma
Oesophageal adenocarcinoma (OAC) has increased dramatically in Western countries, including the UK, over the past 30 years. It usually presents de novo, but is often preceded by Barrett's oesophagus (BO), a premalignant condition whereby the normal squamous epithelium is replaced by columnar lined epithelium with intestinal metaplasia. The main risk factors for BO include male sex, obesity and chronic gastro-oesophageal reflux of acid and bile. The estimated annual risk of BO progression is 0.3%, increasing substantially, up to 30%, when dysplasia is present. (Source: Medicine)
Source: Medicine - April 3, 2019 Category: Internal Medicine Authors: Wladyslaw Januszewicz, Rebecca C. Fitzgerald Tags: Mouth and oesophagus Source Type: research

Clinical Outcomes of Minimally Invasive Enucleation of Leiomyoma of the Esophagus and Esophagogastric Junction
AbstractObjectiveMinimally invasive enucleation is the treatment of choice in symptomatic patients with esophageal leiomyoma. Comprehensive long-term follow-up data are lacking. Aim of this study was to review the clinical outcomes of three procedures for enucleation of leiomyoma of the esophagus and esophagogastric junction.MethodsA single institution retrospective review was performed using a prospectively collected research database and individual medical records. Demographics, presenting symptoms, use of proton-pump inhibitors (PPI), tumor location and size, treatment modalities, and subjective and objective clinical o...
Source: Journal of Gastrointestinal Surgery - April 2, 2019 Category: Surgery Source Type: research

Relationship between esophageal motility abnormalities and skin or lung involvements in patients with systemic sclerosis
AbstractBackgroundEsophageal motility abnormalities (EMAs) and interstitial lung diseases (ILDs) are often seen in patients with systemic sclerosis (SSc). Gastroesophageal reflux disease (GERD) could be associated with ILDs, but it is not fully understood if ILDs are caused by GERD or SSc itself.MethodsA total of 109 patients with SSc who underwent high-resolution manometry were enrolled. Esophageal motility was diagnosed with the Chicago classification v3.0. The severity of skin thickness was evaluated by the modified Rodnan total skin thickness score (mRSS). The severity of ILDs was assessed with the chest high-resolutio...
Source: Journal of Gastroenterology - April 1, 2019 Category: Gastroenterology Source Type: research

The "Aachen sings" study ("Aachen choir engagement study into GERD symptoms"): moderate singing and breathing exercises in a choir reduce reflux symptoms - a cohort study in non-specialist choristers.
The "Aachen sings" study ("Aachen choir engagement study into GERD symptoms"): moderate singing and breathing exercises in a choir reduce reflux symptoms - a cohort study in non-specialist choristers. Z Gastroenterol. 2019 Apr;57(4):491-496 Authors: Dietrich CG, Kottmann T, Labenz J, Streetz K, Hellebrandt P Abstract BACKGROUND:  The influence of singing activities and breathing exercises on the presence of gastroesophageal reflux disease (GERD) symptoms is not clear. While an Austrian study found symptom reduction, an Italian study showed more symptoms in professional opera c...
Source: Zeitschrift fur Gastroenterologie - April 1, 2019 Category: Gastroenterology Authors: Dietrich CG, Kottmann T, Labenz J, Streetz K, Hellebrandt P Tags: Z Gastroenterol Source Type: research

Objective tongue color and gastroesophageal reflux disease: Cross ‐sectional study
This study was done to investigate the utility of tongue color (TC) and FSSG in the diagnosis of GERD.MethodsA total of 886 healthy Japanese residents aged 28 –86 years had a photograph of the tongue taken, completed the FSSG, and underwent esophagogastroduodenoscopy. FSSG ≥8 was defined as GERD, mucosal break on endoscopy as reflux esophagitis (RE), and no erosive esophagitis as non‐erosive reflux disease (NERD). TC was measured using the device‐ independent International Commission on Illumination (CIE) 1976 L*a*b* color space standards at four points.ResultsA total of 152 (17.2%) of the subjec...
Source: Traditional and Kampo Medicine - April 1, 2019 Category: Complementary Medicine Authors: Mosaburo Kainuma, Norihiro Furusyo, Yoshihisa Urita, Hiroaki Ikezaki, Kazuya Ura, Toshiya Nakaguchi, Takao Namiki Tags: ORIGINAL ARTICLE Source Type: research

Investigating the association of proton pump inhibitors with chronic kidney disease and its impact on clinical practice and future research: a review
ConclusionsThe current evidence related to the potential association of CKD with PPI use remains inconclusive in establishing true causality. Further prospective studies including randomised controlled trials and cohort studies would be required to confirm the findings reported in this review and to draw any conclusions. (Source: Journal of Pharmaceutical Policy and Practice)
Source: Journal of Pharmaceutical Policy and Practice - March 29, 2019 Category: Pharmaceuticals Source Type: research

Commentary: Differential foregut function based on type of lung disease —Does it really matter?
Gastroesophageal reflux (GERD) is a frequent issue for patients with end-stage pulmonary disease,1-3 and its impact on outcomes for patients undergoing lung transplantation represents an important area of investigation. Among transplant recipients, GERD has been identified as a contributor to bronchiolitis obliterans syndrome and chronic pulmonary allograft dysfunction.4,5 The link between benign esophageal disease and end-stage lung failure touches on 2 key areas of clinical relevance for thoracic surgeons, taking the stage as a topic of significant interest in our specialty. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - March 29, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Mara B. Antonoff Tags: Commentary Source Type: research

Commentary on “Relationship Between Torticollis and Gastroesophageal Reflux Disorder in Infants”
No abstract available (Source: Pediatric Physical Therapy)
Source: Pediatric Physical Therapy - March 28, 2019 Category: Pediatrics Tags: RESEARCH REPORTS: CLINICAL BOTTOM LINE Source Type: research

Relationship Between Torticollis and Gastroesophageal Reflux Disorder in Infants
Conclusions: The increased likelihood of infants with CMT also having GERD has clinical implications for the pediatric physical therapist. (Source: Pediatric Physical Therapy)
Source: Pediatric Physical Therapy - March 28, 2019 Category: Pediatrics Tags: RESEARCH REPORTS Source Type: research

The Influences of Visceral Fat Area on the Sites of Esophageal Mucosal Breaks in Subjects with Gastroesophageal Reflux Diseases.
Conclusion: The VAT and the VAT/SAT ratio were significantly associated with the mucosal breaks in the LC of EGJ. Visceral obesity could influence the location of the mucosal breaks on EGJ. PMID: 30911296 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - March 28, 2019 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

What Is the Best Operation for Proximal Gastric Cancer and Distal Esophageal Cancer?
This article summarizes the available evidence on this topic, and highlights specific areas for further research. (Source: Surgical Clinics of North America)
Source: Surgical Clinics of North America - March 28, 2019 Category: Surgery Authors: Laura M. Mazer, George A. Poultsides Source Type: research