A141 Laparoscopic vertical gastric clip B-Clamp ® for weight loss: a first European experience
We report the short-term Results of our initial experience in LVGC. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Fr édéric Borel, Patrick Noel, Grégory Baud, Hélène Verkindt, Pamela Nesslany, Naïma Oukhouya Daoud, Moises Jacobs, François Pattou, Robert Caiazzo Source Type: research

A106 Gastroesophageal reflux disease in patients with severe obesity and type 2 diabetes one year after sleeve gastrectomy or Roux-en-Y gastric bypass. A randomized controlled trial.
To compare the effects of sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB) on gastroesophageal reflux disease (GERD) one year after surgery. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - October 1, 2019 Category: Surgery Authors: Jolanta Lorentzen, Asle W. Medhus, Jens Kristoffer Hertel, Tor-Ivar Karlsen, Heidi Borgeraas, Rune Sandbu, Marius Svanevik, Dag Hofs ø, Jøran Hjelmesæth, Birgitte Seip Tags: Tuesday, November 5, 2019 1:30 PM - 3:00 PM Source Type: research

Is there any relation between connective tissue growth factor and scar tissue in vesicoureteral reflux?
Ş Abstract Gültekin ND, Benzer M, Tekin-Neijmann Ş. Is there any relation between connective tissue growth factor and scar tissue in vesicoureteral reflux. Turk J Pediatr 2019; 61: 71-78. Vesicoureteral reflux (VUR) is the most common uropathy in childhood which leads to increased frequency of urinary tract infection (UTI) and renal scarring. Connective tissue growth factor (CTGF) plays an important role in the development of glomerular and tubulointerstitial fibrosis in progressive kidney diseases. The aim of this study was to investigate the relation between urinary CTGF and renal damage resulted from VU...
Source: The Turkish Journal of Pediatrics - September 29, 2019 Category: Pediatrics Authors: Gültekin ND, Benzer M, Tekin-Neijmann Ş Tags: Turk J Pediatr Source Type: research

Cough presentation in primary care and the identification of chronic cough: a need for diagnostic clarity?
Conclusions: The prevalence of CC was lower than reported in previous studies. People with possible CC had higher rates of underlying conditions associated with CC. These observations may suggest poor recognition and/or under-recording of CC in primary care. PMID: 31558053 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 29, 2019 Category: Research Tags: Curr Med Res Opin Source Type: research

Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China.
This study aimed to investigate the changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China, and to explore the clinical significance. Methods: Medical records of 1,311 patients with chronic cough who visit our hospital between January 2009 and December 2016 were retrospectively reviewed. The etiologies of chronic cough were identified according to a standardized step-by-step diagnostic protocol and the changes in the etiological frequency of chronic cough over the years were using the Chi-squared (χ2) test. Results: Cough variant asthma (CVA) (449/1,311, 34.2%), gastroesophage...
Source: Journal of Thoracic Disease - September 28, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The “Silk Road”: A Novel Method for Inserting Transpyloric Feeding Tubes in Low Resource Settings
Transpyloric tube (TPT) feeding is used in a multitude of conditions including gastroesophageal reflux disease. We here describe a new simple method to insert TPTs. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - September 28, 2019 Category: Surgery Authors: Mahmood Kaddah, Naser El-mefleh, Muhammad Eyad Ba'Ath Tags: Case Series Source Type: research

Value of Exhaled Nitric Oxide and FEF25-75 in Identifying Factors Associated With Chronic Cough in Allergic Rhinitis.
CONCLUSIONS: NAEB, CVA, and UACS are common causes of chronic cough in patients with AR. FeNO can first be used to discriminate patients with CVA/NAEB, then FEF25-75 (or combined with FeNO) can further discriminate patients with CVA from those with CVA/NAEB. PMID: 31552718 [PubMed] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - September 27, 2019 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Contribution of magnetic resonance imaging to the management of esophageal diseases: A systematic review
ConclusionMR Esophagography might become a non-invasive, non-irradiating technique of choice following diagnostic esophagogastroduodenoscopy for the assessment of esophageal diseases. (Source: European Journal of Radiology)
Source: European Journal of Radiology - September 27, 2019 Category: Radiology Source Type: research

Does acid reflux precipitate ischaemia in subjects with acute coronary syndrome?
CONCLUSIONS: Although GORD is common in subjects with ACS, we have not been able to show that GORD may serve as a trigger for ischaemia in these subjects. PMID: 31591635 [PubMed - as supplied by publisher] (Source: Cardiovascular Journal of Africa)
Source: Cardiovascular Journal of Africa - September 27, 2019 Category: Cardiology Authors: George SK, Tlou B, Ponnusamy S, Naidoo DP Tags: Cardiovasc J Afr Source Type: research

Statement for gastroesophageal reflux disease after peroral endoscopic myotomy from an international multicenter experience
AbstractIt has been 10  years since peroral endoscopic myotomy (POEM) was reported for the first time, and POEM has currently become the standard treatment for achalasia and related disorders globally because it is less invasive and has a higher curative effect than conventional therapeutic methods. However, there are li mited studies comparing the long-term outcomes of POEM with those of conventional therapeutic methods, particularly in the occurrence of gastroesophageal reflux disease (GERD) after therapy. With this background, we held a consensus meeting to discuss the pathophysiology and management of GERD after P...
Source: Esophagus - September 26, 2019 Category: Gastroenterology Source Type: research

Is the stomach a way to one's heart? Gastric autonomic activity and AF susceptibility in gastroesophageal reflux disease
Journal of Cardiovascular Electrophysiology, EarlyView. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - September 25, 2019 Category: Cardiology Authors: Varun Malik, Dennis H Lau, Dominik Linz, Melissa E. Middeldorp, Prashanthan Sanders Tags: EDITORIAL – INVITED Source Type: research

An Apparent Large Pericardial Effusion: A Consequence of Dual Antiplatelet Therapy or an Entirely Different Diagnosis?
A 71-YEAR-OLD, 67 kg, 170 cm man presented to the authors ’ institution for evaluation of atypical chest pain of 6 months duration. The patient described his chest discomfort as relatively mild. It seldomly persisted for more than a few seconds; was confined to the left chest without radiation; and was not related to activity, position, or breathing. He denied dysphagia, odynophagia, and symptoms of gastroesophageal reflux disease. The patient had a history of chronic atrial fibrillation and peripheral vascular disease for which he received chronic dual antiplatelet therapy (apixaban and clopidogrel). (Source: Journa...
Source: Journal of Cardiothoracic and Vascular Anesthesia - September 24, 2019 Category: Anesthesiology Authors: Paul S. Pagel, Hana T. Millen, Trevor S. Peterson, Sweeta D. Gandhi, Nicole L. Lohr, G. Hossein Almassi Tags: Diagnostic Dilemma Source Type: research

4-Carboxyphenylboronic acid-decorated, redox-sensitive rod-shaped nano-micelles fabricated through co-assembling strategy for active targeting and synergistic co-delivery of camptothecin and gemcitabine.
Abstract To achieve redox-controlled and tumor active targeting synergistic self-delivery of camptothecin and gemcitabine, redox-sensitive rod-shaped nano-micelles are fabricated through co-assembling between camptothecin-disulfide bond-PEG2000-4-carboxyphenylboronic acid and camptothecin-disulfide bond-gemcitabine conjugate. Most of all, for multidrug resistant cancer cell line MCF-7/ADR which is more resistant against CPT, increasing content of CPT in the formulation is favorable for synergistic effect of CPT and GEM drug combination. Benefiting from simple co-assembling strategy, it is easy and convenient to ad...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 24, 2019 Category: Drugs & Pharmacology Authors: Xu Y, Huang Y, Lu W, Liu S, Xiao Y, Yu J Tags: Eur J Pharm Biopharm Source Type: research

Laryngotracheal Stenosis Management: A 16-Year Experience.
Abstract In recent years, it has become increasingly apparent that the laryngotracheal stenosis (LTS) cohort comprises distinct etiological subgroups; however, treatment of the disease remains heterogeneous with limited research to date assessing predictors of treatment outcome. We aim to assess clinical and surgical predictors of endoscopic treatment outcome for LTS, as well as to further characterize the disease population. A retrospective chart review of adult patients with LTS presenting over a 16-year period was conducted. Seventy-five patients were identified and subdivided into 4 etiologic subgroups: iatrog...
Source: Ear, Nose and Throat Journal - September 23, 2019 Category: ENT & OMF Authors: Woliansky J, Paddle P, Phyland D Tags: Ear Nose Throat J Source Type: research

Chinese Medicine JQ Granule Combined with Half-dose Omeprazole for Nonerosive Reflux Disease: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial Study Protocol
This study will evaluate in a large, independent, randomized controlled trial (RCT) the comparative effectiveness of a specific type of Chinese herbal granule with half-dose PPI and full-dose PPI in managing nonerosive reflux disease.Methods and analysisThis trial will be a multicenter, randomized, double-blind, placebo-controlled RCT. A total of 204 participants will be enrolled and randomized (1:1) to each group: herb granules plus 10 mg omeprazole plus 10 mg dummy omeprazole; and dummy herb granules plus 20 mg omeprazole. The efficacy measures will be the changes in scores in the Gastroesophageal Re...
Source: European Journal of Integrative Medicine - September 22, 2019 Category: Complementary Medicine Source Type: research

Review article: Contribution of magnetic resonance imaging to the management of esophageal diseases: a systematic review
ConclusionMR Esophagography might become a non-invasive, non-irradiating technique of choice following diagnostic esophagogastroduodenoscopy for the assessment of esophageal diseases. (Source: European Journal of Radiology)
Source: European Journal of Radiology - September 22, 2019 Category: Radiology Source Type: research

Eosinophilic esophagitis in children: current knowledge to open new horizons.
Authors: Alterio T, Cardile S, Trayers C, Valenti S, Loddo I, Mardare R, Mosca A, Nobili V Abstract Eosinophilic Esophagitis (EoE) is a chronic immune/antigen-mediated condition which is also driven by genetic and environmental factors. It has been deeply investigated over the last years and its incidence is widely increasing in childhood. Although atopic diseases are closely linked with EoE, it does not recognize a classical IgE-mediate immune pathogenesis but it is rather a T helper type 2 inflammatory process. Familial clustering supports genetic predisposition in EoE and recent advances in understanding the gen...
Source: Scandinavian Journal of Gastroenterology - September 21, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Reflux esophagitis, functional and non-functional
Publication date: Available online 17 September 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Serhat BorAbstractThe pathogenesis of gastroesophageal reflux disease has been explained by acid-peptic model. However, related with the progress of the diagnostic modalities, another phenotypical group of patients were defined and called “functional disorders of the esophagus”. These patients are important because diagnosis is particularly difficult, co-morbid disorders especially psychiatric diseases are common, proton pump inhibitor response is low, and surgical results are very poor. ...
Source: Best Practice and Research Clinical Gastroenterology - September 21, 2019 Category: Gastroenterology Source Type: research

Management of Gastroesophageal Reflux Disease in the Elderly Patient
AbstractGastroesophageal reflux disease (GERD) is an especially common disorder in the elderly population. Its presentation in this population is often different  from that in younger patients. A greater proportion of patients experience atypical GERD symptoms rather than heartburn or regurgitation, increasing the likelihood the diagnosis will be missed or overlooked. Elderly patients more commonly present with severe erosive esophagitis and GERD complicati ons compared with younger patients, and thus may require more aggressive therapy. While diagnostic work-up and management of GERD in elderly patients is similar to...
Source: Drugs and Aging - September 21, 2019 Category: Geriatrics Source Type: research

Mucosal impedance testing: A new diagnostic testing in gastroesophageal reflux disease
In conclusion, endoscopic MIT measurement can differentiate esophageal disorders instantly during endoscopy. It may not only serve as an important tool in diagnosing of GERD but also help guide therapy in clinically difficult situations as a surrogate to predict the treatment response. (Source: Journal of the Formosan Medical Association)
Source: Journal of the Formosan Medical Association - September 20, 2019 Category: General Medicine Source Type: research

Left Transthoracic Approach for Magnetic Sphincter Augmentation Device LINX Implantation
Publication date: October 2019Source: The Annals of Thoracic Surgery, Volume 108, Issue 4Author(s): Saleh A. Alnasser, Hai V. Salfity, Jacob A. Klapper, Matthew G. HartwigMagnetic sphincter augmentation with the LINX Reflux Management System (Torax Medical, St. Paul, MN) is a recently introduced surgical option with comparable therapeutic efficacy for medically refractory gastroesophageal reflux disease. An appropriately sized LINX device is usually placed around the gastroesophageal junction through a laparoscopic approach. In general, redo abdominal surgeries are technically challenging, with a higher risk of associated ...
Source: The Annals of Thoracic Surgery - September 20, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Epidemiology of idiopathic pulmonary fibrosis: a population-based study in primary care
AbstractIdiopathic pulmonary fibrosis (IPF) is a chronic disease with unknown etiology and poor prognosis. Little is known about the epidemiology of this disease; most of the studies are limited by small and restricted cohort studies. We aim to investigate the epidemiology of IPF in the Italian primary care setting using the Health Search Database (HSD) between January 2002 and June 2017. In an attempt to define cases of IPF we adopted iterative combinations of International Classification of Diseases Ninth Revision (ICD-9-CM) and other clinical investigations according to three different operational Algorithms. Incidence ...
Source: Internal and Emergency Medicine - September 20, 2019 Category: Emergency Medicine Source Type: research

“Reflux esophagitis, functional and non-functional”
Publication date: Available online 17 September 2019Source: Best Practice & Research Clinical GastroenterologyAuthor(s): Serhat BorABSTRACT:The pathogenesis of gastroesophageal reflux disease has been explained by acid-peptic model. However, related with the progress of the diagnostic modalities, another phenotypical group of patients were defined and called “functional disorders of the esophagus”. These patients are important because diagnosis is particularly difficult, co-morbid disorders especially psychiatric diseases are common, proton pump inhibitor response is low, and surgical results are very poor....
Source: Best Practice and Research Clinical Gastroenterology - September 19, 2019 Category: Gastroenterology Source Type: research

42 - A Multicentre, Prospective, Observational Study of Diabetes Self-Management and Behavioural Change in Newly Referred Patients to Diabetes Education Centres
Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7, SupplementAuthor(s): James M. Bowen, Robert B. Hopkins, LIFENG Xie, Gord Blackhouse, Daria J. O’reilly (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - September 19, 2019 Category: Endocrinology Source Type: research

The Role of Gastroesophageal Reflux in Patients with Acquired Tracheal Stenosis
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - September 19, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Benny Weksler Source Type: research

Commentary: The role of gastroesophageal reflux in patients with acquired tracheal stenosis
Gastroesophageal reflux (GERD) has been associated with several pulmonary and airway pathologies, including asthma, subglottic stenosis, pulmonary fibrosis, and bronchiolitis obliterans in patients who had a lung transplantation. Surgical treatment of GERD improves survival in patients with pulmonary fibrosis,1 improves lung allograft function,2 and decreases the need for steroids in patients with asthma.3 Idiopathic tracheal stenosis appears to be associated with GERD,4 and the treatment of GERD might improve outcomes. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - September 19, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Benny Weksler Tags: Commentary Source Type: research

Gastric cancer and gastrin: on the interaction of Helicobacter pylori gastritis and acid inhibitory induced hypergastrinemia.
Authors: Waldum HL, Rehfeld JF Abstract Gastric cancer, a disease with a reduced frequency for decades, now appears to be on the rise again in young Americans. The epidemiology of gastric cancer differs between tumors in the cardia and those of the more distal parts of the stomach. The tumors are divided into the intestinal type showing glandular growth pattern and the diffuse type with a different pattern. The latter often expresses neuroendocrine and more specifically ECL-cell markers suggesting that they originate from the ECL cell, the target cell for the antral hormone, gastrin. Helicobacter pylori gastritis i...
Source: Scandinavian Journal of Gastroenterology - September 18, 2019 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Mucosal impedance testing: A new diagnostic testing in gastroesophageal reflux disease.
In conclusion, endoscopic MIT measurement can differentiate esophageal disorders instantly during endoscopy. It may not only serve as an important tool in diagnosing of GERD but also help guide therapy in clinically difficult situations as a surrogate to predict the treatment response. PMID: 31542333 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - September 18, 2019 Category: General Medicine Authors: Lei WY, Vaezi MF, Naik RD, Chen CL Tags: J Formos Med Assoc Source Type: research

Simple Niobium Catalysts Applied in Reflux and Ultrasound-Assisted Systems for Biofuel Synthesis
Using niobium compounds as heterogeneous catalysts in biodiesel production is a promising methodology from economic and environmental viewpoints. However, the application of niobium catalysts still is a challenge due to the high temperatures and pressures for moderate biofuel yields. Therefore, easily handled and applied materials have been developed to optimize biofuel production, which is the goal of this study. Nb2O5 and ammonium niobium oxalate (AmNO) were activated in reflux and ultrasound-assisted system. Nb2O5 showed better activity under reflux, using methanol. The characterizations conclude that the Lewis-acid sit...
Source: Journal of the Brazilian Chemical Society - September 17, 2019 Category: Chemistry Source Type: research

Concomitant endoscopic fundoplication – can it reduce the risk of gastroesophageal reflux following peroral endoscopic myotomy?
Endoscopy DOI: 10.1055/a-1000-8196 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - September 17, 2019 Category: Gastroenterology Authors: Bapaye, Amol Dharamsi, Siddharth Jain, Rishabh Basava, Guru Bapaye, Jay A. Pujari, Rajendra Gadhikar, Harshal Tags: E-Videos Source Type: research

108 A Prospective Audit and Review of Proton Pump Inhibitors (PPIs) in Older Adults in a Reablement Unit
ConclusionMost patients on a PPI did not have a clear indication.The majority of inappropriate PPIs were deemed suitable for review and were subsequently dose reduced or discontinued.Some patients were unsuitable for PPI review due to multiple risk factors or ongoing symptoms of reflux.The continued need for PPIs should be assessed regularly and a risk-benefit analysis should be carried out. (Source: Age and Ageing)
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

193 Audit on Inappropriate Prescribing of Proton Pump Inhibitors Amongst Patients over 65 Years in an Acute Rehabilitation Hospital
ConclusionThis audit highlighted the inappropriate prescribing of PPI ’s in the older person. By providing education to Doctors about NICE PPI prescribing guidelines, overall rate of inappropriate prescribing of PPI decreased by 28.4% and accurate dosing of PPI improved by 21.2%. (Source: Age and Ageing)
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

Bariatric Surgery After Previous Antireflux Surgery Without Takedown of the Previous Fundoplication: a Prospective Study
ConclusionBariatric surgery is possible after fundoplication without taking down the fundoplication. It appears to be a viable alternative in patients seeking weight loss surgery after fundoplication, which is currently assumed contraindicated. (Source: Obesity Surgery)
Source: Obesity Surgery - September 16, 2019 Category: Surgery Source Type: research

Management of uncomplicated gastric ulcer in community pharmacy: a pseudo-patient study
ConclusionThe questioning skill of the  community pharmacists in this setting was poor. Few community pharmacists diagnosed the pseudo-patients’ minor ailment correctly. Also, recommendations were mostly inappropriate compared with the standard treatment guideline. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - September 16, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluating the Effect of Oral Gabapentin on the Improvement of Gastrointestinal Symptoms in Patients with Functional Dyspepsia Resistant to Conventional Treatments.
Conclusion: Gabapentin as an adjunctive drug could be more effective in reducing the severity of GI symptoms in patients with dyspepsia, especially neurological symptoms (such as pain, reflux, and indigestion). PMID: 31516891 [PubMed] (Source: Biomed Res)
Source: Biomed Res - September 15, 2019 Category: Research Authors: Shafigh-Ardestani MH, Karami-Horestani M, Emami B, Arjmandpour A Tags: Adv Biomed Res Source Type: research

Regioselective hydroxylation pathway of tenatoprazole to produce human metabolites by Bacillus megaterium CYP102A1
In conclusion, an enzymatic synthesis of 5’-OH tenatoprazole, a major human metabolite of tenatoprazole, was developed by using mutants of CYP102A1 from Bacillus megaterium as a biocatalyst and tenatoprazole as a substrate.Graphical abstract (Source: Process Biochemistry)
Source: Process Biochemistry - September 15, 2019 Category: Biochemistry Source Type: research

Esophageal pH-impedance monitoring in children: position paper on indications, methodology and interpretation by the SIGENP working group
Multichannel intraluminal impedance pH (MII-pH) monitoring currently represents the gold standard diagnostic technique for the detection of gastro-esophageal reflux (GER), since it allows to quantify and characterize all reflux events and their possible relation with symptoms. Over the last ten years, thanks to its strengths and along with the publication of several clinical studies, its worldwide use has gradually increased, particularly in infants and children. Nevertheless, factors such as the limited pediatric reference values and limited therapeutic options still weaken its current clinical impact. (Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - September 13, 2019 Category: Gastroenterology Authors: Paolo Quitadamo, Renato Tambucci, Valentina Mancini, Fernanda Cristofori, Mariella Baldassarre, Licia Pensabene, Ruggiero Francavilla, Giovanni Di Nardo, Tamara Caldaro, Paolo Rossi, Saverio Mallardo, Elena Maggiora, Annamaria Staiano, Francesco Cresi, Si Tags: Position Paper Source Type: research

Is the stomach a way to one's heart? Gastric autonomic activity and AF susceptibility in gastro ‐esophageal reflux disease
This article is protected by copyright. All rights reserved. (Source: Journal of Cardiovascular Electrophysiology)
Source: Journal of Cardiovascular Electrophysiology - September 13, 2019 Category: Cardiology Authors: Varun Malik, Dennis H Lau, Dominik Linz, Melissa E. Middeldorp, Prashanthan Sanders Tags: EDITORIAL – INVITED Source Type: research

Development of scores assessing the refluxogenic potential of diet of patients with laryngopharyngeal reflux
ConclusionREDS, RESDI and GRES are proposed as objective scores for assessing the refluxogenic potential of F&B composing a dish or the overall diet of LPR patients. Future studies are needed to study the correlation between these scores and the development of LPR according to impedance –pH study. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - September 12, 2019 Category: ENT & OMF Source Type: research

Gastroesophageal Reflux Disease and Atrial fibrillation: Insight from Autonomic Cardiogastric Neural Interaction
In this study, we investigated the effects of acid reflux on the intrinsic cardiac autonomic nervous system, atrial/ventricular electrophysiology, and AF inducibility.MethodsEighteen rabbits were randomized into three groups: acid reflux (group 1, n = 6), control (group 2, n = 6), and acid reflux with periesophageal vagal blockade (group 3, n = 6). Atrial and ventricular effective refractory periods (ERPs) and AF inducibility were checked at baseline and then hourly until 5 hours after the experiment.ResultsThree hours after the experiment, atrial ERP prolongation was noted in groups 2 and 3 (P
Source: Journal of Cardiovascular Electrophysiology - September 12, 2019 Category: Cardiology Authors: Ting ‐Chun Huang, Li‐Wei Lo, Shinya Yamada, Yu‐Hui Chou, Wei‐Lun Lin, Shih‐Lin Chang, Yenn‐Jiang Lin, Shin‐Huei Liu, Wen‐Han Cheng, Tsung‐Ying Tsai, Ping‐Yen Liu, Shih‐Ann Chen Tags: ORIGINAL ‐ EXPERIMENTAL Source Type: research

Increase in lumbar kyphosis and spinal inclination, declining back muscle strength, and sarcopenia are risk factors for onset of GERD: a 5-year prospective longitudinal cohort study
The objective was to identify risk factors for new development of gastroesophageal reflux disease (GERD) 5  years later in a prospective longitudinal cohort study.MethodsA total of 178 subjects (male 72, female 106, mean age 68  years) without GERD in 2013 were examined for GERD in 2018. A Frequency Scale for Symptoms of GERD score ≥ 8 was used for diagnosis of GERD. Body mass index, spinal alignment, muscle strength, physical ability, number of oral drugs per day, sarcopenia, and frailty determined in 2013 and 2018 w ere compared between the GERD(+) and GERD(−) groups in 2018. Aggravation of lumb...
Source: European Spine Journal - September 10, 2019 Category: Orthopaedics Source Type: research

Magnetic Sphincter Augmentation Superior to Proton Pump Inhibitors for Regurgitation in a 1-year Randomized Trial
Regurgitative gastroesophageal reflux disease (GERD) refractive to medical treatment is common and caused by mechanical failure of the anti-reflux barrier. We compared the effects of magnetic sphincter augmentation (MSA) with those of proton-pump inhibitors (PPIs) in a randomized trial. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - September 10, 2019 Category: Gastroenterology Authors: Reginald Bell, John Lipham, Brian E. Louie, Valerie Williams, James Luketich, Michael Hill, William Richards, Christy Dunst, Dan Lister, Lauren McDowell-Jacobs, Patrick Reardon, Karen Woods, Jon Gould, F. Paul Buckley, Shanu Kothari, Leena Khaitan, C. Dan Source Type: research

Role and safety of fundoplication in esophageal disease and dysmotility syndromes.
Authors: Bakhos CT, Petrov RV, Parkman HP, Malik Z, Abbas AE Abstract Gastroesophageal reflux disease (GERD) is quite prevalent worldwide, especially in the western hemisphere. The pathophysiology of GERD is complex, involving an incompetent esophagogastric junction (EGJ) as an anti-reflux barrier, as well as other co-morbid conditions such as gastroparesis, hiatal herniation or hyper acid secretion. Esophageal dysmotility is also frequently encountered in GERD, further contributing to the disease in the form of fragmented peristalsis, ineffective esophageal motility (IEM) or the more severe aperistalsis. The latte...
Source: Journal of Thoracic Disease - September 7, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The role of diet in the development and management of gastroesophageal reflux disease: why we feel the burn.
Authors: Newberry C, Lynch K Abstract Gastroesophageal reflux disease (GERD) is a common esophageal disorder that is characterized by troublesome symptoms associated with increased esophageal acid exposure. Cornerstones of therapy include acid suppressive agents like proton pump inhibitors (PPI) and lifestyle modifications including dietary therapy, although the latter is not well defined. As concerns regarding long term PPI use continue to be explored, patients and providers are becoming increasingly interested in the role of diet in disease management. The following is a review of dietary therapy for GERD with an...
Source: Journal of Thoracic Disease - September 7, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Associations of the microbiome and esophageal disease.
Authors: Okereke I, Hamilton C, Wenholz A, Jala V, Giang T, Reynolds S, Miller A, Pyles R Abstract The incidence of esophageal diseases such as esophageal adenocarcinoma (EAC) and gastroesophageal reflux disease (GERD) have been increasing over the last 40 years. The esophageal microbiome appears to have a role in the development of some disease processes, and could also serve as markers of early diseases of the esophagus. A literature review was performed examining the role of the microbiome in the development of esophageal disease. In addition, the results of several studies and experiments were included in the r...
Source: Journal of Thoracic Disease - September 7, 2019 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Gastroesophageal reflux disease, obesity and laparoscopic sleeve gastrectomy: The burning questions.
Abstract Obesity is a global health epidemic with considerable economic burden. Surgical solutions have become increasingly popular following technical advances leading to sustained efficacy and reduced risk. Sleeve gastrectomy accounts for almost half of all bariatric surgeries worldwide but concerns regarding its relationship with gastroesophageal reflux disease (GERD) has been a topic of debate. GERD, including erosive esophagitis, is highly prevalent in the obese population. The role of pre-operative endoscopy in bariatric surgery has been controversial. Two schools of thought exist on the matter, one that bel...
Source: World Journal of Gastroenterology - September 7, 2019 Category: Gastroenterology Authors: Bou Daher H, Sharara AI Tags: World J Gastroenterol Source Type: research

Oesophageal intramural pseudodiverticulosis: a rare endoscopic finding.
This report highlights the occurrence of this rare and benign cause of dysphagia in Nigeria. Funding: None declared. PMID: 31481816 [PubMed - in process] (Source: Ghana Medical Journal)
Source: Ghana Medical Journal - September 6, 2019 Category: African Health Tags: Ghana Med J Source Type: research

Neuroendocrine cell hyperplasia of infancy: An unusual cause of unresolving tachypnea in infancy
A 6-month-old full-term male patient was born uneventfully through vaginal delivery. At the age of 3 months, he began experiencing unresolving dry cough and poor feeding. During respiratory auscultation, tachypnea without adventitious breath sounds was noted. Chest radiograph (CxR) based from the latest admission revealed ground-glass opacity (GGO) and hyperinflation in bilateral lung fields (Supplement Fig.). Meanwhile, echocardiogram showed a patent foramen ovale, while esophagogram was negative for tracheoesophageal fistula or gastroesophageal reflux. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - September 6, 2019 Category: Perinatology & Neonatology Authors: Sui-Ling Liao, Shen-Hao Lai Tags: Letter to the Editor Source Type: research

Short-Term and Long-Term Outcomes of Paraesophageal Hernia Repair
The assessment of outcome after paraesophageal repair is difficult and complex. There is a wide range of reported outcomes that are not consistently defined. The focus of this article is on short-term ( ≤5 years) and long-term (>5  year) outcomes after laparoscopic paraesophageal repair and reviews key patient-reported outcomes (gastroesophageal reflux disease [GERD]–related and non–GERD-related symptoms), radiologic recurrence, additional therapy, and objective measurements. Overall, patients reported an excellent impro vement in their quality of life after repair that remains durable. Recurren...
Source: Thoracic Surgery Clinics - September 6, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Anne-Sophie Laliberte, Brian E. Louie Source Type: research

Management of Paraesophageal Hernia in the Morbidly Obese Patient
Gastroesophageal reflux disease (GERD) is common in the morbidly obese population, and hiatal hernias are encountered in 20% to 52% of patients. Primary surgical repair of hiatal hernias, in particular the paraesophageal type, is associated with a higher recurrence rate in obese patients. Concomitant weight loss surgery may be advisable. Combined sleeve gastrectomy and paraesophageal hiatal hernia repair is feasible but can induce or worsen preexisting GERD. A Roux-en-Y gastric bypass offers advantages of more pronounced excess weight loss and better symptom control, albeit with a potentially higher rate of morbidity compa...
Source: Thoracic Surgery Clinics - September 6, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Charles T. Bakhos, Shrey P. Patel, Roman V. Petrov, Abbas E. Abbas Source Type: research