Managing radioiodine refractory thyroid cancer: the role of dosimetry and redifferentiation on subsequent I-131 therapy.
We describe the role of dosimetry in redifferentiation and subsequent I-131 therapy in RAI-R thyroid cancer, explain different dosimetry approaches and discuss limitations and considerations in the field. PMID: 32744039 [PubMed - in process] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - August 4, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Using 99mTc-(V)-DMSA to follow the vascular calcification process in vascular smooth muscle cells based on pit-1 expression.
Authors: Bonnefoy PB, Jacqueroux E, Delavenne X, Roche F, Clotagatide A, Mismetti P, Prevot N, Perek N Abstract BACKGROUND: Vascular calcification is an established feature of atherosclerosis process. The sodium/phosphate transporter PiT-1 acts as a biosensor in vascular calcification of VSMCs. [99mTc]-Pentavalent dimercaptosuccinic acid (99mTc-(V)-DMSA) was mediated by PiT-1 transporter in tumoral cells and we propose its evaluation in a vascular calcification in vitro model. The aim of this study was to determine if 99mTc-(V)-DMSA can follow the vascular calcification process in vascular smooth muscle cells (VSMC...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - June 18, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Choline PET/CT features to predict survival outcome in high risk prostate cancer restaging: a preliminary machine-learning radiomics study.
CONCLUSIONS: An artificial intelligence model demonstrated to be feasible and able to select a panel of 18F-Cho PET/CT features with valuable association with PCa patients' outcome. PMID: 32543166 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - June 18, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Targeted Alpha Therapy: a critical review of translational dosimetry research with emphasis on Actinium-225.
Authors: Seoane DC, De Saint-Hubert M, Crabbe M, Struelens L, Koole M Abstract This review provides a general overview of the current achievements and challenges in translational dosimetry for Targeted Alpha therapy (TAT). The concept of Targeted Radionuclide Therapy (TRNT) is described with an overview of its clinical applicability and the added value of TAT is discussed. For TAT, we focused on 225Ac (actinium-225) as an example for alpha particle emitting radionuclides and their features, such as limited range within tissue and high linear energy transfer, which make alpha particle emissions more effective in tar...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - May 24, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Prognostic and predictive role of the tumor immune landscape.
Authors: Haanen JB, Blank CU Abstract Cancer immunotherapy utilizing immune checkpoint inhibitors, has become mainstay for a growing number of cancer types. However, in general, the objective response rate and survival is only improved in a minority of cancer patients. Many of the biomarkers to select patients that either benefit or do not, have next to being predictive also prognostic value, are continuous instead of categorical, and are therefore difficult to use in daily practice. Currently, PD-L1 by immunohistochemical staining is the only approved biomarker to select metastatic non-small cell lung cancer patie...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - May 19, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Molecular imaging of norepinephrine transporter-expressing tumors: current status and future prospects.
Authors: Pauwels E, van Aerde M, Bormans G, Deroose CM Abstract The human norepinephrine transporter (hNET) is a transmembrane protein responsible for reuptake of norepinephrine in presynaptic sympathetic nerve terminals and adrenal chromaffin cells. Neural crest tumors, such as neuroblastoma, paraganglioma and pheochromocytoma often show high hNET expression. Molecular imaging of these tumors can be done using radiolabeled norepinephrine analogs that target hNET. Currently, the most commonly used radiopharmaceutical for hNET imaging is meta-[123I]iodobenzylguanidine ([123I]MIBG) and this has been the case since it...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - May 15, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Nuclear medicine radiomics in precision medicine: why we can't do without artificial intelligence.
Authors: Noortman WA, Vriens D, Grootjans W, Tao Q, De Geus-Oei LF, van Velden FH Abstract In recent years, radiomics, defined as the extraction of large amounts of quantitative features from medical images, has gained emerging interest. Radiomics consists of the extraction of handcrafted features combined with sophisticated statistical methods or machine learning algorithms for modelling, or deep learning algorithms that both learn features from raw data and perform modelling. These features have the potential to serve as non-invasive biomarkers for tumour characterisation, prognostic stratification and response p...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - May 15, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Nuclear medicine in precision oncology.
Authors: de Geus-Oei LF, Deroose CM PMID: 32343513 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - April 29, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Characterization of heterogeneity of hypoxia with 18FMISO PET/CT, BOLD fMRI and immunohistochemistry in human breast tumor xenograft: initial study.
Authors: Cheng J, Zhang J, He S, Qi M, Zhang Y, Zhu X, Zhang Y, Zhang J, Geng D Abstract BACKGROUND: To demonstrate that both 18F-fluoromisonidazole positron emission tomography computed tomography (18F-MISO PET/CT) and function magnetic resonance imaging blood oxygenation level dependent (fMRI BOLD) can map intratumoral sub-region of hypoxia consistently. METHODS: The MCF-7 xenograft was established and hypoxia were divided into three subtypes by animal 18F-MISO PET/CT scan. Using tumor to background ratio (TBR)>1.40 and hypoxia sub-volume (HSV) / tumor volume (TV) ≧ 50% as threshold, hypoxia was divided ...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - April 15, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Volumetric 68Ga-DOTA-TATE PET/CT for assessment of whole-body tumor burden as a quantitative imaging biomarker in patients with metastatic gastroenteropancreatic neuroendocrine tumors.
CONCLUSIONS: SSR-derived volumetric parameters provide a quantitative imaging biomarker for whole-body tumor burden, and may hold potential as a clear-cut measure for assessment of treatment response. PMID: 32286768 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - April 15, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Preclinical imaging for targeting cancer immune evasion.
Authors: Terlizzi C, De Rosa V, Iommelli F, Altobelli GG, Fonti R, Del Vecchio S Abstract Novel anticancer immunotherapy strategies such as immune checkpoint blockade have been successfully employed in patients with a variety of cancers and became a therapeutic option in the treatment of several malignancies. However, long-term durable responses to immune checkpoint inhibitors are currently limited to a fraction of patients raising the need of an accurate selection of potentially responding patients. Although several biomarkers have been proposed for patient selection and prediction of response to immune checkpoint...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - April 15, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Immunoscore and its introduction in clinical practice.
Authors: Galon J, Lanzi A Abstract Current cancer classification is based on intrinsic tumor parameters such as characteristic of tumor cells, tumor progression, tumor invasion and the presence of distant metastases, as summarized by the AJCC/UICC-TNM stratification system. There is currently no immune- based classification of cancer. We provided evidence that the immune contexture, as defined by the type, density, functional immune orientation and the location of immune cells within tumor, strongly influences the outcome of colorectal cancer (CRC) patients. To translate this information to the clinic, we developed...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 29, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

The LIPI score and inflammatory biomarkers for selection of patients with solid tumors treated with checkpoint inhibitors.
Authors: Benitez JC, Recondo G, Rassy E, Mezquita L Abstract In the last decade, immune checkpoint inhibitors (ICI) have completely changed the treatment strategy and the prognosis of several solid cancer types. There is a lack of biomarkers to differ between responders and non-responders to these therapies. The development of biomarkers for immunotherapy has been mainly focused on tumor-related factors. The role of PD-L1 expression or tumor mutational burden (TMB) as potential predictive biomarkers for ICI efficacy is not universal and remains controversial. Moreover, leukocyte and neutrophil counts in blood sampl...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 29, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Update on tumor metabolism and patterns of response to immunotherapy.
Authors: Castello A, Lopci E Abstract Immune checkpoint inhibitors (ICI) represent a cornerstone in cancer treatment. However, the peculiarity of immune response, determining distinctive response patterns and toxicity events, challenges the conventional response criteria. Therefore, the effective tumor response and the real clinical benefit cannot be demonstrated adequately. In this context, recent studies using 2-deoxy-2-[18F]fluoro-D-glucose ([18F]) positron emission tomography/computed tomography (PET/CT) have shown promising results for therapeutic monitoring during ICI, although further research is needed to c...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 29, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Cancer management in the era of immunotherapy: "much more than what strikes the eyes".
Cancer management in the era of immunotherapy: "much more than what strikes the eyes". Q J Nucl Med Mol Imaging. 2020 Feb 27;: Authors: Lopci E, Haanen J PMID: 32107905 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 29, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Clinical imaging of cardiovascular inflammation.
Authors: Calcagno C, Fayad ZA Abstract Cardiovascular disease due to atherosclerosis is the number one cause of morbidity and mortality worldwide. In the past twenty years, compelling preclinical and clinical data have indicated that a maladaptive inflammatory response plays a crucial role in the development of atherosclerosis initiation and progression in the vasculature, all the way to the onset of life-threatening cardiovascular events. Furthermore, inflammation is key to heart and brain damage and healing after myocardial infarction or stroke. Recent evidence indicates that this interplay between the vasculatur...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Current and novel radiopharmaceuticals for imaging cardiovascular inflammation.
Authors: Heo GS, Sultan D, Liu Y Abstract Cardiovascular disease (CVD) remains the leading cause of death worldwide despite advances in diagnostic technologies and treatment strategies. The underlying cause of most CVD is atherosclerosis, a chronic disease driven by inflammatory reactions. Atherosclerotic plaque rupture could cause arterial occlusion leading to ischemic tissue injuries such as myocardial infarction (MI) and stroke. Clinically, most imaging modalities are based on anatomy and provide limited information about the on-going molecular activities affecting the vulnerability of atherosclerotic lesion for...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Inflammation imaging to define vulnerable plaque or vulnerable patient.
Authors: Vigne J, Hyafil F Abstract The role of nuclear imaging in the characterization of high risk atherosclerotic plaque is increasing thanks to its high sensitivity to detect radiopharmaceuticals signal in tissues. Currently, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) is the most studied and widely used radiopharmaceutical for the molecular imaging of atherosclerotic plaques with positron emission tomography (PET). [18F]FDG PET is a valuable tool to non-invasively detect, monitor and quantify inflammatory processes occurring in atherosclerotic plaques. The aim of this review is to gather insights provided by [1...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Imaging inflammation after myocardial infarction. Implications for prognosis and therapeutic guidance.
Authors: Iking J, Klose J, Staniszewska M, Fendler W, Herrmann K, Rischpler C Abstract Inflammation after myocardial infarction (MI) has been in the focus of cardiovascular research for several years as it influences the remodelling process of the ischaemic heart and thereby critically determines the clinical outcome of the patient. Today, it is well appreciated that inflammation is a crucial necessity for the initiation of the natural wound healing process; however, excessive inflammation can have detrimental effects and might result in adverse ventricular remodelling which is associated with an increased risk of ...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Predictive factors of preoperative sentinel lymph node detection in intermediate and high-risk endometrial cancer.
Authors: Angeles MA, Migliorelli F, León Ramírez LF, Ros C, Perissinotti A, Tapias A, Casanueva-Eliceiry S, Pahisa J, Torné A, Vidal-Sicart S, Del Pino M, Paredes P Abstract BACKGROUND: In endometrial cancer (EC), sentinel lymph node (SLN) mapping has emerged as an alternative to systematic lymphadenectomy. Little is known about factors that might influence SLN preoperative detection. The aim of our study is to evaluate the clinical and technical variables that may influence on the success of SLN detection in preoperative lymphatic mapping in patients with intermediate and high-risk EC when per...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 22, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Imaging inflammation in cardiovascular disease: translational perspective and overview.
Authors: Thackeray JT, Taqueti VR PMID: 32043341 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - February 12, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Benefit of including CT urography in 68Ga-PSMA-11 PET/CT with low-dose CT: first results from a larger prostate cancer cohort analysis.
CONCLUSIONS: CT urography benefits the interpretation of 68Ga-PSMA-11 PET/CT with low-dose CT and leads to discrepant patient treatment in a small but significant subset of patients (12% in our cohort). The implementation of CT urography into standard protocols of 68Ga-PSMA-11 PET/CT with low-dose CT is recommended. PMID: 31992688 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - January 30, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Imaging cardiac sarcoidosis and infiltrative diseases: diagnosis and therapeutic response.
Authors: Elwazir MY, Bois JP, Abouezzeddine OF, Chareonthaitawee P Abstract Infiltrative heart disease is an encompassing term referring to different pathological entities that involve infiltration of the myocardium by either abnormal substances or inflammatory cells. These infiltrates can impair cellular function, induce necrosis and fibrosis, or otherwise disrupt myocardial architecture resulting in a wide spectrum of structural and functional impairment. Depending on the specific disorder and stage of disease, patients may present with minimal cardiac abnormalities, or may have findings of advanced restrictive a...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - January 30, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Respiratory gated multistatic PET reconstructions to delineate radiotherapy target volume in patients with mobile lung tumours.
Authors: Hapdey S, Bouyeure-Petit AC, Chastan M, Thureau S, Gouel P, Edet-Sanson A, Becker S, Dubray B, Vera P Abstract BACKGROUND: PET-CT with 18F-FDG or other radiopharmaceuticals is a recommended tool to help the delineation of lung cancers candidate to radiotherapy. The motion artifacts caused by respiratory movements are reduced by 4D acquisitions. We introduced an extended reconstruction algorithm (Multiple Reconstruct Register and Average: Multi-RRA) which requires much shorter acquisition times than standard 4D PET-CT. Our aim was to evaluate the interest on multi-RRA images as an alternative of 3D and 4D P...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - January 12, 2020 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Uptake pattern of [68Ga]Ga-DOTA-NOC in tissues: implications for inflammatory diseases.
CONCLUSIONS: Tissues in which lymphocytic infiltration may occur show that SUVmax is tissue-dependent. Within tissue variability, an SUVmax greater than the mean +3SD is rarely found amongst patients without a symptomatic chronic inflammatory process but, when found, may highlight a chronic inflammatory condition. PMID: 31833738 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - December 14, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Changes over the years in radiopharmaceutical design.
Authors: Eckelman WC, Kuwert T, Ciarmiello A, Riondato M, Mansi L Abstract Of the many uses of radiopharmaceuticals, developing radiotracers that contribute significantly to diagnosis and therapy of patients has been a major focus. This requires a broad spectrum of expertise including that of the attending physician who lends insight to an unmet clinical need neither addressed by other imaging techniques nor by analysis of tissue, blood, and urine for diagnostics and addressed by pharmaceuticals for therapeutic applications. The design criteria have depended on radiochemistry, on matching the radiopharmaceutical wi...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - December 14, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

82Rubidium chloride PET discrimination of recurrent intracranial malignancy from radiation necrosis.
CONCLUSIONS: 82RbCl PET produces high-contrast uptake of both recurrent disease and radiation necrosis compared to normal brain. However, no statistically significant difference was found between recurrent tumor and radiation necrosis. PMID: 31820882 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - December 12, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Prognostic importance of PSA response in patients who received Lutetium-177 PSMA treatment for castration resistant prostate cancer.
This study aims to analyze the prognostic importance of serum PSA response in patients who received radioligand therapy (RLT) with Lu-177 Prostate-specific membrane antigen (PSMA) for their castration-resistant prostate cancer. METHODS: Thirty consecutive patients who received Lu-177 PSMA treatment for their castration-resistant prostate carcinoma were included. All the patients had undergone Ga-68 PSMA PET/CT scanning before Lu-177 PSMA therapy, which revealed multiple metastases. Patients were treated with a fixed dose (180 mCi) of Lu-177 PSMA at six to eight weeks intervals. Prostate specific antigen (PSA) response ...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - October 13, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Fully integrated 18F-FDG PET/MR in large vessel vasculitis.
CONCLUSIONS: PET/MR is a safe imaging technique capable of detecting inflammation in aortic wall. Low radiological exposure of PET/MR should be considered especially in young women receiving follow-up studies. PMID: 31602964 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - October 13, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Dosimetrically determined activities in advanced differentiated thyroid carcinoma: controversies.
Authors: Finessi M, Liberini V, Deandreis D Abstract The 2013/59 EURATOM directive defines all nuclear medicine applications for therapeutic purpose as a form of radiotherapy and underlines the need of both justification and optimization of these procedures, including radioactive iodine therapy (RAIT) with [131I] for metastatic differentiated thyroid cancer (DTC), In metastatic DTC, optimal activity to be administered to achieve the best response rate with limited toxicity is still a matter of debate and international guidelines do not provide univocal recommendations on the preferable use of empiric versus a dosim...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - September 28, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Radiomics in nuclear medicine and hybrid imaging: current standings on clinical applicability.
Authors: Veit-Haibach P, El Naqa I, Visvikis D PMID: 31560184 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - September 28, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

CT radiomics and PET radiomics: ready for clinical implementation?
Authors: Bogowicz M, Vuong D, Huellner MW, Pavic M, Andratschke N, Gabrys HS, Guckenberger M, Tanadini-Lang S Abstract Today, rapid technical and clinical developments result in an increasing number of treatment options for oncological diseases. Thus, decision support systems are needed to offer the right treatment to the right patient. Imaging biomarkers hold great promise in patient-individual treatment guidance. Routinely performed for diagnosis and staging, imaging datasets are excepted to hold more information than used in the clinical practice. Radiomics describes the extraction of a large number of meaningfu...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - September 20, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Are radiomics ready for clinical prime-time in PET/CT imaging?
Authors: Cheze Le Rest C, Hustinx R Abstract Over the last few years the field of radiomics has been gaining ground in the field of nuclear medicine and in multimodality imaging. Within this context, numerous studies have exploited the potential interest of radiomics in clinical practice, within the diagnostic field as well as in prognostic and predictive modeling of patient response. Although these studies have showed some interesting results, there are also persistent conflicting conclusions. Most of these studies suffer from consistently low number of patients, lack of external dataset based validation of most f...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - September 20, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Machine learning for radiomics-based multi-modality and multi-parametric modeling.
Authors: Wei L, Osman S, Hatt M, El Naqa I Abstract Due to the recent developments of both hardware and software technologies, multimodality medical imaging techniques have been increasingly applied in clinical practice and research studies. Previously, the application of multimodality imaging in oncology has been mainly related to combining anatomical and functional imaging to improve diagnostic specificity and/or target definition, such as positron emission tomography/computed tomography (PET/CT) and single-photon emission computed tomography (SPECT)/CT. More recently, the fusion of various images, such as multi-...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - September 20, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Integrating radiomics into clinical trial design.
Authors: Waninger JJ, Green M, Cheze Le Rest C, Rosen B, El Naqa I Abstract In radiomics, quantitative features that describe phenotypic tumor characteristics are derived from radiographic images. Because radiomics generates information from routine medical images, it is a powerful way to non-invasively examine the spatial and temporal heterogeneity of disease, and thus has potential to significantly impact clinical trial design, execution, and ultimately patient care. The aim of this review article is to discuss how radiomics may address some of the current challenges in clinical randomized control trials, and the...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - September 20, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Role of intravoxel incoherent motion parameters in gastro-esophageal cancer: relationship with 18F-FDG-PET, CT perfusion and MR perfusion imaging parameters.
This study evaluated the relationship of multimodality parameters derived from intravoxel incoherent motion method (IVIM), 18F- FDG-PET, CT perfusion and dynamic contrast enhanced MRI in patients with gastro- esophageal cancer and investigated their histopathological correlation. METHODS: Thirty-one consecutive patients (28 male; median age 63.9 years; range 37-84 years) with gastro-esophageal adenocarcinoma (n=22) and esophageal squamous cell carcinoma (n=9) were analyzed. IVIM parameters: pseudodiffusion (D*), perfusion fraction (fp), true diffusion (D) and the threshold b-value (bval); PET-parameters: SUVmax, metabo...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - September 11, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

PET imaging of Dopamine Transporter with [18F]LBT-999: initial evaluation in healthy volunteers.
CONCLUSIONS: These findings support the usefulness of [18F]LBT-999 for a quantitative clinical evaluation of presynaptic dopaminergic innervation. PMID: 31496203 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - September 11, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Evaluation of quantitative imaging parameters in head and neck squamous cell carcinoma.
CONCLUSIONS: Functional imaging represents an attractive and non-invasive modality to assess complex biological phenomena in solid tumors. Larger tumor volume and increasing hypoxia emerged as putative prognostic imaging biomarkers in HNSCC. PMID: 31496204 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - September 11, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Sterility assurance of technetium-99m radiopharmaceuticals: no specific air conditions are required for their preparation, storage and dispensation.
CONCLUSIONS: This study strongly supports that it is not necessary any special ambient air conditions to prepare, store and dispense extemporaneous technetium-99m radiopharmaceuticals in order to preserve their sterility when the basic aseptic rules for closed procedures are followed. PMID: 31359743 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - August 1, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

PSMA uptake on [68Ga]-PSMA-11-PET/CT positively corrects with prostate cancer aggressiveness.
This study is to validate the relationship between SUVs with prostate cancer (PCa) aggressiveness and its role in evaluation of clinically significant PCa (csPCa) and risk stratification. METHODS: We retrospectively enrolled 51 patients who underwent [68Ga]-PSMA PET/CT (PET/CT) before radical prostatectomy (RP). PET/CT results were corrected with whole mount histology. The relationship between SUVs and aggressiveness related indictors including Gleason score, T stage, initial PSA and tumor size were analyzed. The cutoff value for detection of overall PCa, csPCa and intermediate/high-risk PCa were calculated by receiver...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - August 1, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Radioiodine dosimetry in advanced thyroid cancer.
Authors: Giovanella L, Lassmann M Abstract PMID: 31333007 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 25, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Physics aspects of setting up a multi-centre clinical trial involving internal dosimetry of radioiodine treatment of differentiated thyroid cancer.
Authors: Taprogge J, Leek F, Flux GD Abstract The field of molecular radiotherapy is expanding rapidly, with the advent of many new radiotherapeutics for the treatment of common as well as for rare cancers. Treatment outcome is dependent on the absorbed doses delivered to target volumes and to healthy organs-at-risk, which are shown to vary widely from fixed administrations of activity. There have been significant developments in quantitative imaging and internal dosimetry in recent years, although clinical implementation of these methods has been slow in comparison with external beam radiotherapy, partly due to th...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 19, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Molecular imaging of bone metastases using tumor-targeted tracers.
Authors: Karamzade-Ziarati N, Manafi-Farid R, Ataeinia B, Langsteger W, Pirich C, Mottaghy FM, Beheshti M Abstract Bone metastasis is a disastrous manifestation of most malignancies, especially in breast, prostate and lung cancers. Since asymptomatic bone metastases are not uncommon, early detection, precise assessment, and localization of them are very important. Various imaging modalities have been employed in the setting of diagnosis of bone metastasis, from plain radiography and bone scintigraphy to SPECT, SPECT/CT, PET/CT, MRI. However, each modality showed its own limitation providing accurate diagnostic perf...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 19, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Radionuclide imaging and therapy of bone metastases in the era of targeted therapy.
Authors: van den Wyngaert T, Paycha F Abstract PMID: 31315348 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 19, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

The role of 124I PET/CT lesion dosimetry in differentiated thyroid cancer.
Authors: Weber M, Binse I, Nagarajah J, Bockisch A, Herrmann K, Jentzen W Abstract Radioiodine therapy of thyroid cancer was the first successful radionuclide therapy in the treatments of cancer, although its clinical use is empirical and not based on precise dosimetry. 124I is a positron- emitting radionuclide and positron emission tomography/computed tomography (PET/CT) with 124I currently provides the most accurate estimation of the absorbed (radiation) dose to thyroid cancer lesions. In the application, serial 124I PET/CT scans are performed to determine the time uptake curves and to delineate the volumes of th...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 13, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Bone metastases in the era of targeted treatments: insights from molecular biology.
Authors: Dewulf J, Vangestel C, Verhoeven Y, van Dam P, Elvas F, van den Wyngaert T, Clézardin P Abstract Bone metastases remain a common feature of advanced cancers and are associated with significant morbidity and mortality. Recent research has identified promising novel treatment targets to improve current treatment strategies for bone metastatic disease. This review summarizes the well-known and recently discovered molecular biology pathways in bone that govern normal physiological remodelling or drive the pathophysiological changes observed when bone metastases are present. In the rapidly changing world...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 13, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Quantitative radionuclide imaging of bone metastases.
Authors: De Schepper S, Ritt P, van den Wyngaert T, Kuwert T Abstract By improving the localization of foci of pathological tracer uptake and offering information on their CT morphology, SPECT/CT hybrid imaging has considerably improved the diagnostic accuracy of skeletal scintigraphy. SPECT/CT also has the potential to measure tracer uptake in vivo in absolute units. The present article reviews the methodology for and the potential clinical impact of quantitative skeletal scintigraphy. PMID: 31298016 [PubMed - as supplied by publisher] (Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging)
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 13, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

The changing role of radium-223 in mCRPC: has the European Medicines Agency missed the mark with revising the label?
Authors: van den Wyngaert T, Tombal B Abstract Radium-223 is a life prolonging treatment in symptomatic men with metastatic castrate resistant prostate cancer (mCRPC) and bone metastases, but no visceral disease, regardless of prior treatment with docetaxel. Together with four other drugs (i.e. abiraterone, cabazitaxel, docetaxel, enzalutamide), it has been available for clinical use since 2013 and has been shown to also provide benefits in quality-of-life and societal benefits. However, in 2018 the European Medicines Agency (EMA) ruled to restrict the use of radium-223 to a more advanced disease setting after at l...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 13, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Response assessment of bone metastatic disease: seeing the forest for the trees - RECIST, PERCIST, iRECIST, and PCWG-2.
Authors: Castello A, Lopci E Abstract Tumor response is often used as a surrogate marker for survival practically in all clinical trials. Therefore robust and valid response criteria during the course of trials are fundamental for the assessment of response to therapy. This aspect, however, becomes particularly challenging when it comes to bone metastases. In the era of targeted therapies and immune-checkpoint inhibitors (ICI), response assessment by morphologic-based criteria cannot detect the real tumor response and, consequently, fail to demonstrate the actual clinical benefit. This review will focus on some of ...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 11, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research

Molecular imaging of bone metastases using bone targeted tracers.
Authors: Vaz S, Sharjeel U, Gnanasegaran G, Paycha F, van der Wyngaert T Abstract Molecular imaging using bone targeted tracers has been used in clinical practice for almost fifty years and still plays an essential role in the diagnosis and follow-up of bone metastases. It includes both [99mTc]bisphosphonates for bone scan and [18F]NaF for PET/CT which are very sensitive to detect osteoblastic activity, but it is important to consider several aspects to increase the specificity of reported findings (such as specific tracer characteristics and mechanism of action, patient's clinical history, common metastatic patter...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - July 11, 2019 Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research