P.01.20 e-cadherin and epidermal growth factor (egf) as non-invasive biomarkers predictive of gastro-esophageal reflux disease
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: E. Sanvito, M. Antonelli, L. Ciavarella, G. Distefano, G. Mazzoleni, C. Belloni, R. Daverio, M. Locatelli, P.A. Testoni, S. Passaretti Tags: Posters Source Type: research

P.01.9 effectiveness of pepsino ®, a novel medical device containing hyaluronic acid and alginate, for the treatment of laryngopharyngeal reflux symptoms
(Source: Digestive and Liver Disease)
Source: Digestive and Liver Disease - March 25, 2019 Category: Gastroenterology Authors: F. Ingravalle, C. Tosetti, E. Benedetto, G. Casella, M. Zamparella, P. Gambaro, E. Savarino, R. De Bastiani Tags: Posters Source Type: research

Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications
AbstractAllergic eosinophilic esophagitis (EoE) is a chronic, allergen-mediated inflammatory disease of the esophagus, and the most common cause of prolonged dysphagia in children and young adults in the developed world. While initially undistinguished from gastroesophageal reflux disease-associated esophageal eosinophilia, EoE is now recognized as a clinically distinct entity that shares fundamental inflammatory features of other allergic conditions and is similarly increasing in incidence and prevalence. The clinical and epidemiologic associations between EoE and other allergic manifestations are well established. In add...
Source: Clinical Reviews in Allergy and Immunology - March 22, 2019 Category: Allergy & Immunology Source Type: research

Duodenogastric biliary reflux assessed by scintigraphic scan in patients with reflux symptoms after sleeve gastrectomy: preliminary results
Bile reflux is a factor in the appearance of severe esophagitis and Barrett ´s esophagus which have been reported after a sleeve gastrectomy (SG). Incompetent lower esophageal sphincter and increased gastroesophageal acid reflux have been demonstrated after this operation. Some reports have shown bile content in the antrum during endoscopic control but there are no investi gations that objectively confirm the presence of duodenogastric bile reflux in these patients. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - March 22, 2019 Category: Surgery Authors: Dr. Italo Braghetto, Patricio Gonzalez, Cesar Lovera, Manuel Figueroa-Giralt, Amy Pi ñeres Tags: Original articles Source Type: research

Effect of EP1 Receptor Antagonist on Transient Lower Esophageal Sphincter Relaxations in Humans
Conclusions: ONO-8539 suppressed TLESRs mildly. EP1 receptor may be involved with the mechanism of human TLESRs.Digestion (Source: Digestion)
Source: Digestion - March 21, 2019 Category: Gastroenterology Source Type: research

Efficacy of Vonoprazan, a Novel Potassium-Competitive Acid Blocker, in Patients with Proton Pump Inhibitor-Refractory Acid Reflux
Conclusion: In patients with PPI-refractory GERD, VPZ provides more potent gastric acid suppression, more effective EAE control, enhanced symptom improvement, and better esophagitis healing than PPIs.Digestion (Source: Digestion)
Source: Digestion - March 21, 2019 Category: Gastroenterology Source Type: research

Association between endoscopic findings of eosinophilic esophagitis and responsiveness to proton pump inhibitors
This study included 106 patients with esophageal eosinophilia. Esophageal eosinophilia was defined as a condition where the maximum number of intraepithelial eosinophils was ≥ 15 per high-power field. LEoE was defined as an endoscopic lesion confined to one-third of the esophagus: upper, middle, or lower. Esophageal eosinophilia encompassing more than two-thirds of the esophagus was defined as DEoE. We retrospectively compared LEoE and DEoE in terms of clinical characteristics, histologic findings, and proportion of proton pump inhibitor (PPI) responders. Results Of 106 patients, 12 were classified as having ...
Source: Endoscopy International Open - March 21, 2019 Category: Gastroenterology Authors: Sawada, Akinari Hashimoto, Atsushi Uemura, Risa Otani, Koji Tanaka, Fumio Nagami, Yasuaki Yamagami, Hirokazu Tanigawa, Tetsuya Watanabe, Toshio Fujiwara, Yasuhiro Tags: Original article Source Type: research

Large Hiatal Hernia Repair with Urinary Bladder Matrix Graft Reinforcement and Concomitant Sleeve Gastrectomy.
Conclusion: In this series of 32 cases, laparoscopic cruroplasty with UBM graft reinforcement has been effective and durable at 12 months of followup. This technique may offer one satisfactory solution for large hiatal hernia repair concomitant with laparoscopic sleeve gastrectomy that may achieve a durable repair with low GERD symptoms. PMID: 30880900 [PubMed - in process] (Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons)
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - March 19, 2019 Category: Surgery Tags: JSLS Source Type: research

Esophageal Melanosis: A Rare Condition of Undetermined Significance
A 57-year-old woman underwent elective esophagogastroduodenoscopy as part of the workup for iron deficiency anemia. She denied abdominal pain, gastroesophageal reflux disease, dysphagia, or weight loss. Esophagogastroduodenoscopy showed a darkly pigmented desquamated patch of approximately 3 cm in the mid-esophagus (Figure A). Biopsy of the patch showed unusual hyperpigmentation at the basal layer of the epithelium (Figure B) with no atypia, and immunohistochemistry stain for melanocytes was positive (Figure C), consistent with esophageal melanosis. (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - March 19, 2019 Category: Gastroenterology Authors: Navroop Nagra, Gaurav Singhvi, Lucilene Tolentino Tags: Electronic Image of the Month Source Type: research

Diagnosis and Management of Gastroesophageal Reflux Disease
This Clinical Guideline Synopsis discusses the 2018 Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - March 18, 2019 Category: Pediatrics Source Type: research

Boix-Ochoa (Partial Fundoplication) Treats Reflux, Even in Neurologically Impaired Patients. Can it Take the Title of “Gold Standard” from Total Fundoplication?
ConclusionAlthough there has not any literature demonstrating significant benefits of one procedure, we detected with this largest study in the pediatric literature about Boix-Ochoa fundoplication (more physiologic and easily performed) that it was successful (95%) in protecting reflux even in neurologically impaired patients (98%). We consider Boix-Ochoa (partial fundoplication) to be an alternative method to Nissen (complete fundoplication), and it can be done safely with a high success rate. (Source: Journal of Gastrointestinal Surgery)
Source: Journal of Gastrointestinal Surgery - March 18, 2019 Category: Surgery Source Type: research

Total esophagogastric dissociation (TEGD): Lessons from two decades of experience
We describe our institution ’s experience of TEGD in this selected cohort of patients. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - March 18, 2019 Category: Surgery Authors: Riccardo Coletta, Bashar Aldeiri, Raef Jackson, Antonino Morabito Source Type: research

Left Trans-thoracic Approach for Magnetic Sphincter Augmentation Device LINX® Implantation
Publication date: Available online 16 March 2019Source: The Annals of Thoracic SurgeryAuthor(s): S.A. Alnasser, H.V. Salfity, J.A. Klapper, M.G. HartwigAbstractMagnetic Sphincter augmentation with the LINX® Reflux Management System is a recently introduced surgical option with comparable therapeutic efficacy for medically refractory gastroesophageal reflux disease. An appropriately sized LINX® device is usually placed around the gastroesophageal junction through laparoscopic approach. In general, redo abdominal surgeries are technically challenging with a higher risk of associated morbidity. This highlights the nee...
Source: The Annals of Thoracic Surgery - March 17, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research

Effects of Nissen Fundoplication on Markers of Microaspiration and Inflammation after Lung Transplantation
Gastroesophageal reflux disease (GERD) is prevalent after lung transplantation (LTx) and has been associated with allograft injury and chronic lung allograft dysfunction (CLAD) presumably through chronic microaspiration of bile acids and other gastric contents with subsequent innate immune activation. Anti-reflux surgery is widely used at some centers to treat GERD in LTx; however, its role in inflammation or aspiration is unknown. Our objective was to examine the effects of early anti-GERD surgery in LTx recipients on markers of microaspiration and inflammation in the bronchoalveolar lavage (BAL). (Source: The Journal of ...
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: K.C. Zhang, S.E. Hunter, E. Huszti, M. Ahmed, L. Levy, K.M. Boonstra, A.T. Sage, S. Azad, R. Zamel, C. Frankel, M. Budev, P. Shah, L.D. Snyder, J. Belperio, L.G. Singer, S.S. Weigt, J.L. Todd, S. Keshavjee, S.M. Palmer, T. Martinu, for the CTOT-20 Investi Tags: 157 Source Type: research

A Combination of Delayed Gastric Emptying and Gastroesophageal Reflux Disease is Associated with Worse Outcomes in Lung Transplantation
Gastroparesis and GERD are very common conditions in patients with end-stage lung disease and can be exacerbated after lung transplantation (LTx). At our center, we routinely test lung transplant recipients (LTRs) for gastric emptying abnormalities and for GERD at 3 months post-transplant. We hypothesized that LTRs with significant gastroparesis and/or GERD are more likely to develop lung injury leading to subsequent CLAD and death. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: J. Fernandez-Castillo, E. Huszti, K.C. Zhang, R. Ghany, L. Levy, D.R. Darley, C. Chaparro, J. Tikkanen, S. Keshavjee, L. Singer, J.C. Yeung, T. Martinu Tags: 275 Source Type: research

Lung Bile Acid as Biomarker of Microaspiration and Its Relationship to Lung Inflammation
Gastroesophageal reflux disease (GERD) is thought to expose the lungs to refluxed gastric contents leading to injury and chronic lung allograft dysfunction (CLAD) in lung transplant recipients (LTRs). Prior small studies showed correlations between lung bile acids and CLAD/survival. The goal of this study was to determine whether bile acid levels in the bronchoalveolar lavage (BAL) correlate with GERD, concurrent lung allograft inflammation, or development of CLAD. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - March 16, 2019 Category: Transplant Surgery Authors: M. Ahmed, L. Levy, S.E. Hunter, K.C. Zhang, E. Huszti, K.M. Boonstra, A.T. Sage, S. Azad, R. Zamel, R. Ghany, J.C. Yeung, O.M. Crespin, C. Frankel, M. Budev, P. Shah, L.D. Snyder, J. Belperio, L.G. Singer, S.S. Weigt, J.L. Todd, S.M. Palmer, S. Keshavjee, Tags: 625 Source Type: research

Update on the clinical development of gefapixant, a P2X3 receptor antagonist for the treatment of refractory chronic cough
Publication date: Available online 14 March 2019Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): David Muccino, Stuart GreenAbstractChronic cough, or cough lasting>8 weeks, is often associated with underlying medical conditions (ie, asthma, gastroesophageal reflux disease, nonasthmatic eosinophilic bronchitis, and upper-airway cough syndrome). In some patients with chronic cough, treatment of these underlying conditions does not resolve the cough (refractory chronic cough [RCC]), or none of these conditions are present (unexplained chronic cough [UCC]). Despite appropriate medical evaluation, patients with RC...
Source: Pulmonary Pharmacology and Therapeutics - March 16, 2019 Category: Respiratory Medicine Source Type: research

Risk factors for incident central serous retinopathy: case-control analysis of a US national managed care population.
Abstract AIM: To evaluate clinical comorbidities and steroid use as risk factors for central serous retinopathy (CSR). METHODS: Using national insurance databases, we conducted a case-control study of beneficiaries with an incident diagnosis of CSR between 2007 and 2015 (n=35 492) and randomly selected controls matched on age-based and sex-based propensity scores (n=1 77 460). RESULTS: The mean age (SD) of cases was 49.1 (12.2) years, and the majority (69.2%) were male. Cases were more likely to have received steroids in the past year (OR 1.14, 95% CI 1.09 to 1.19, p
Source: The British Journal of Ophthalmology - March 14, 2019 Category: Opthalmology Authors: Zhou M, Bakri SJ, Pershing S Tags: Br J Ophthalmol Source Type: research

Impact of Chronic Statins Use on the Development of Esophagitis in Patients with Gastroesophageal Reflux Disease.
Authors: Khoury T, Mari A, Amara H, Jabaren M, Watad A, Nseir W, Sbeit W, Mahamid M Abstract Background and Aims: We aimed to assess whether chronic statins used (> 6 months) were protective of the development of esophagitis in patients with gastroesophageal reflux disease. In the presence of esophagitis, complications such as strictures, Barrett's esophagus, and adenocarcinoma were the most common. Statins, lipid lowering drugs with a pleiotropic effect, are recently implicated in various pathologies. Nevertheless, the possible impact of statins in esophagitis development has never been assessed. Methods: W...
Source: Canadian Journal of Gastroenterology - March 13, 2019 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

The effectiveness of mindfulness meditation in relief of symptoms of depression and quality of life in patients with gastroesophageal reflux disease
In this study, we looked at the effectiveness of mindfulness-based stress reduction (MBSR) in relieving the symptoms of depression and the health-related quality of life of these patients.MethodsA longitudinal, interventional open-label study was carried out on 60 patients with GERD and 60 controls. Zung Self-Rating Depression Scale (ZSDS) was used for assessing depression before and after the intervention. The GERD-Health-Related Quality of Life (GERD-HRQL) questionnaire was used to assess the health-related quality of life and the Freiburg Mindfulness Inventory (FMI) to quantify the amount of mindfulness over the study p...
Source: Indian Journal of Gastroenterology - March 13, 2019 Category: Gastroenterology Source Type: research

Synthesis of Novel Bis-pyrazole Derivatives as Antimicrobial Agents.
CONCLUSION: The good results of the antimicrobial examination of the new synthesized bis-pyrazoles is the considerable evidence of the importance of bis-heterocyclic compounds which encourage us to continue to design and synthesis a novel series with potent biological activity in the future. PMID: 30864524 [PubMed - as supplied by publisher] (Source: Molecular Medicine)
Source: Molecular Medicine - March 12, 2019 Category: Molecular Biology Authors: Muhammad ZA, Alshehrei F, Zayed MEM, Farghaly TA, Abdallah MA Tags: Mini Rev Med Chem Source Type: research

Correction to: Proton pump inhibitor monotherapy is effective to attenuate dyspepsia symptoms associated with gastroesophageal reflux disease: a multicenter prospective observational study
In the original publication of this article, Tables 2, 3, 4, 5 and 6 were published incorrectly. The correct tables are given below. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - March 11, 2019 Category: Gastroenterology Source Type: research

Role of Late DMSA Renal Scan in Detecting High-Grade Vesicoureteral Reflux
ConclusionsIn older children, the normal late DMSA scan predicted the absence of high-grade VUR, obviating the need for a VCUG. This approach could be a possible strategy for children not studied at acute infection time. (Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - March 11, 2019 Category: Pediatrics Source Type: research

Can Impedance-pH Testing on Medications Reliably Identify Patients with GERD as Defined by Pathologic Esophageal Acid Exposure off Medications?
ConclusionMII-pH testingon medications in patients with refractory GERD symptoms does not reliably correlate with a diagnosis of GERD as defined by pathologic esophageal acid exposure off medications. The commonly used abnormal MII-pH test value of ≥ 48 total reflux episodes is not validated and should not be used. However, in our series, patients with>  73 total reflux episodes had a high likelihood of having pathologic acid exposure off medications. Overall, the preferred strategy to evaluate patients with persistent GERD symptoms on acid suppression therapy should be pH testingoff medications. (Sourc...
Source: Journal of Gastrointestinal Surgery - March 11, 2019 Category: Surgery Source Type: research

Lifetime-filtered laser-induced exciplex fluorescence for crosstalk-free liquid-vapor imaging
Laser-induced exciplex fluorescence is a well-established technique for liquid-vapor imaging in evaporating sprays that offers phase-dependent spectrally separated emission. However, the accuracy of this approach is limited by substantial crosstalk from the liquid to vapor phase signals. This ... (Source: Optics Letters)
Source: Optics Letters - March 8, 2019 Category: Physics Authors: Alber Douglawi Venkat Athmanathan Mikhail N. Slipchenko James R. Gord Terrence R. Meyer Source Type: research

Relationship Between Torticollis and Gastroesophageal Reflux Disorder in Infants.
CONCLUSIONS: The increased likelihood of infants with CMT also having GERD has clinical implications for the pediatric physical therapist. PMID: 30865145 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Source: Physical Therapy - March 8, 2019 Category: Physiotherapy Authors: Bercik D, Diemer S, Westrick S, Worley S, Suder R Tags: Pediatr Phys Ther Source Type: research

Efficacy and safety of one anastomosis gastric bypass versus Roux-en-Y gastric bypass for obesity (YOMEGA): a multicentre, randomised, open-label, non-inferiority trial
This study is registered with ClinicalTrials.gov, number NCT02139813, and is now completed.FindingsFrom May 13, 2014, to March 2, 2016, of 261 patients screened for eligibility, 253 (97%) were randomly assigned to OAGB (n=129) or RYGB (n=124). Five patients did not undergo their assigned surgery, and after undergoing their surgery 14 were excluded from the per-protocol analysis (seven due to pregnancy, two deaths, one withdrawal, and four revisions from OAGB to RYGB) In the per-protocol population (n=117 OAGB, n=117 RYGB), mean age was 43·5 years (SD 10·8), mean BMI was 43·9 kg/m2 (SD 5·6), 176 ...
Source: The Lancet - March 7, 2019 Category: General Medicine Source Type: research

Lacrimal Drainage Obstruction and Gastroesophageal Reflux Disease: A Nationwide Longitudinal Cohort Study
This study aimed to evaluate the association between gastroesophageal reflux disease (GERD) and development of lacrimal drainage obstruction (LDO). Background: It has been hypothesized that GERD may contribute toward the development of LDO. Study: This was a retrospective study of Koreans aged 40 to 79 years registered in the Korean National Health Screening Cohort from 2002 to 2013. Incident cases of LDO were identified according to the Korean Classification of Disease. We compared hazard ratios (HRs) for LDO between 22,570 patients with GERD and 112,850 patients without GERD by 1:5 propensity score-matched analysis...
Source: Journal of Clinical Gastroenterology - March 7, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Unilateral Versus Bilateral Lung Transplantation: Do Different Esophageal Risk Factors Predict Chronic Allograft Failure?
Conclusion: The type of LTx performed seems to lead to different risk factors for the development of o-CLAD. Physicians should be aware of these differences, as they may need to be taken into account when managing patient’s post-LTx. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - March 7, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Gastro-oesophageal reflux in children: surgical management
Publication date: Available online 5 March 2019Source: Surgery (Oxford)Author(s): Dhanya Mullassery, Matthew O. JonesAbstractGastro-oesophageal reflux disease (GORD) is symptomatic reflux of gastric contents into the oesophagus. Factors predisposing to GORD are loss of the physiological antireflux barrier and anatomic abnormalities of the oesophagus or diaphragm. Conservative measures and medical management results in resolution of symptoms in a majority of children. Surgery is indicated in the event of failure of medical management or severe complications. Surgical procedures include open or laparoscopic fundoplication in...
Source: Surgery (Oxford) - March 6, 2019 Category: Surgery Source Type: research

Why chronic cough in children is different
Publication date: Available online 6 March 2019Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Ahmad Kantar, Manuela SeminaraAbstractRecently, there have been robust changes in our knowledge of the neurophysiology of cough and novel clinical etiologies. Specifically, cough hypersensitivity in adults and protracted bacterial bronchitis (PBB) in children have been increasingly investigated, and differences between chronic cough in children and adults have been widely reported. In young children, postinfectious cough, bronchiectasis, airway malacia, PBB, and asthma appear to be the main causes of cough; however, b...
Source: Pulmonary Pharmacology and Therapeutics - March 6, 2019 Category: Respiratory Medicine Source Type: research

Quantitative femtosecond, two-photon laser-induced fluorescence of atomic oxygen in high-pressure flames
Quantitative femtosecond two-photon laser-induced fluorescence of atomic oxygen was demonstrated in an H_2/air flame at pressures up to 10   atm. Femtosecond excitation at 226.1   nm was used to pump the 3pP3_J^ ′ =0,1,2 ← ← 2pP3_J^ ′ ′ =0,1,2 electronic ... (Source: Applied Optics)
Source: Applied Optics - March 6, 2019 Category: Physics Authors: K. Arafat Rahman Venkat Athmanathan Mikhail N. Slipchenko Sukesh Roy James R. Gord Zhili Zhang Terrence R. Meyer Source Type: research

Gastroesophageal Reflux Induces Protein Adducts in the Esophagus.
PMID: 30827415 [PubMed - in process] (Source: Molecular Medicine)
Source: Molecular Medicine - March 6, 2019 Category: Molecular Biology Authors: Caspa Gokulan R, Adcock JM, Zagol-Ikapitte I, Mernaugh R, Williams P, Washington KM, Boutaud O, Oates JA, Dikalov SI, Zaika AI Tags: Cell Mol Gastroenterol Hepatol Source Type: research

Comparison of Partial vs Total Fundoplication for the Treatment of Gastroesophageal Reflux Disease
This randomized clinical trial attempts to determine whether partial or total fundoplication is superior for treating gastroesophageal reflux disease. (Source: JAMA Surgery)
Source: JAMA Surgery - March 6, 2019 Category: Sports Medicine Source Type: research

Similar Effectiveness of Total and 270 ° Posterior Fundoplication for Gastroesophageal Reflux Disease
This study confirms the results of a randomized clinical trial of open total and posterior partial fundoplication with 2 decades of follow-up, which showed that the 2 procedures result in similar control of reflux. The results of the study by Håkanson et al are also supported by randomized trials and meta-analysis. (Source: JAMA Surgery)
Source: JAMA Surgery - March 6, 2019 Category: Sports Medicine Source Type: research

Screening for Barrett's Esophagus--Balancing Clinical Value and Cost-effectiveness.
Authors: Patel A, Gyawali CP Abstract In predisposed individuals with long standing gastroesophageal reflux disease (GERD), esophageal squamous mucosa can transform into columnar mucosa with intestinal metaplasia, commonly called Barrett's esophagus (BE). Barrett's mucosa can develop dysplasia, which can be a precursor for esophageal adenocarcinoma (EAC). However, most EAC cases are identified when esophageal symptoms develop, without prior BE or GERD diagnoses. While several gastrointestinal societies have published BE screening guidelines, these vary, and many recommendations are not based on high quality evidenc...
Source: Journal of Neurogastroenterology and Motility - March 6, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Surgical outcomes and risk assessment for anastomotic complications after laparoscopic proximal gastrectomy with double-flap technique for upper-third gastric cancer
This study was a retrospective review aimed to demonstrate details of surgical outcomes and to assess risk factors for anastomotic complications using pre-operative CT image after LPG with DFT (LPG –DFT).MethodsPatient background data, surgical outcomes, post-operative courses, and complications for patients who underwent LPG –DFT from January 2013 to June 2017 were collected. In addition to the details of short-term outcomes, risk factors for anastomotic stricture and gastroesophageal reflux were analyzed.ResultsThe study sample was 147 patients, including 139 patients with upper-third gastric cancer and 8 pat...
Source: Gastric Cancer - March 6, 2019 Category: Gastroenterology Source Type: research

CuCl/bpy-promoted unusual Z-stereoselective synthesis of trichloroacetic acid phenyl ester for Hirshfeld surface analysis and DFT study
Publication date: Available online 2 March 2019Source: Journal of Molecular StructureAuthor(s): Ram Kumar Tittal, Ram Nath Ram, Ayushi Nirwan, Vikas D. Ghule, Satish KumarAbstractA trichloromethyl ester devoid of suitably substituted CC bond, any leaving group or a H-atom at the β-position to the radical, which are otherwise known for ATRA/ATRC, 1,2-rearrangement/fragmentation or simple 1,2-H shift respectively, in a reaction of trichloro-acetic acid phenyl ester with 2 mol equiv CuCl/bpy in reflux DCE or benzene under inert N2 condition resulted to stereoselective synthesis of Z-2,3-dichloro-but-2-enedioic acid dip...
Source: Journal of Molecular Structure - March 5, 2019 Category: Molecular Biology Source Type: research

Gastro-oesophageal reflux in children: surgical management
Gastro-oesophageal reflux disease (GORD) is symptomatic reflux of gastric contents into the oesophagus. Factors predisposing to GORD are loss of the physiological antireflux barrier and anatomic abnormalities of the oesophagus or diaphragm. Conservative measures and medical management results in resolution of symptoms in a majority of children. Surgery is indicated in the event of failure of medical management or severe complications. Surgical procedures include open or laparoscopic fundoplication in children with normal neurology; fundoplication with or without vagotomy and pyloroplasty; surgical feeding jejunostomy and o...
Source: Surgery (Medicine Publishing) - March 5, 2019 Category: Surgery Authors: Dhanya Mullassery, Matthew O. Jones Tags: Paediatric surgery – I Source Type: research

Possible application of trefoil factor family peptides in gastroesophageal reflux and Barrett’s esophagus
Publication date: Available online 1 March 2019Source: PeptidesAuthor(s): Adam Fabisiak, Adrian Bartoszek, Grzegorz Kardas, Natalia Fabisiak, Jakub FichnaAbstractGastroesophageal reflux disease (GERD) is a chronic disorder of the digestive tract characterised mainly by a heartburn. Being one of the most common gastrointestinal diseases, the prevalence of GERD reaches up to 25.9% in Europe. Barrett’s esophagus (BE) is an acquired condition characterized by the replacement of the normal stratified squamous epithelium with metaplastic columnar epithelium. BE is believed to develop mainly from chronic GERD and is the mos...
Source: Peptides - March 4, 2019 Category: Biochemistry Source Type: research

Altered T Cell Migratory Capacity in the Progression from Barrett Oesophagus to Oesophageal Adenocarcinoma
This study examined the chemokine networks governing T cell migration to oesophageal tissue during disease progression. Here, we have identified that circulating T cells in OAC patients, exhibit impaired migratory capacity with decreased frequencies of Th1-associated CXCR3+ and Th17-associated CCR6+ cells. Despite the abundance of Th1 chemokines RANTES (CCL5) and MIP-1 α (CCL3) in OAC tumour, enrichments of intratumoural T cells expressing corresponding receptors were not observed. These data suggest that T cell infiltration of oesophageal tissue is compromised in OAC and suggest that future therapies targeting T cel...
Source: Cancer Microenvironment - March 4, 2019 Category: Cancer & Oncology Source Type: research

Overview of eosinophilic oesophagitis.
Abstract Eosinophilic oesophagitis is a disease that has been recognized in the past 30 years. It causes dysphagia and other symptoms of oesophageal dysfunction. Eosinophilic oesophagitis presents either with a chronic feeling of difficulty swallowing, with food moving slowly through the oesophagus, or as an acute food bolus obstruction requiring emergency attention. Patients may also experience chest pain at this time. It is an inflammatory disorder, thought to be driven by food or environmental antigens, where the most distinctive cell type is eosinophils. Eosinophilic oesophagitis is mediated through a local Ig...
Source: British Journal of Hospital Medicine - March 2, 2019 Category: Internal Medicine Authors: Attwood SE Tags: Br J Hosp Med (Lond) Source Type: research

Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate
Publication date: Available online 1 March 2019Source: Journal of Pharmaceutical AnalysisAuthor(s): Arun Kumar Awasthi, Lalit Kumar, Punit Tripathi, Madhava Golla, Cirandur Suresh Reddy, Pramod KumarAbstractPantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopeia (USP) specified six impurities, viz.; impurities A, B, C, D, E and F, respectively for this active pharmaceutical in...
Source: Journal of Pharmaceutical Analysis - March 1, 2019 Category: Drugs & Pharmacology Source Type: research

Association between tea consumption and gastroesophageal reflux disease: A meta-analysis: Erratum
No abstract available (Source: Medicine)
Source: Medicine - March 1, 2019 Category: Internal Medicine Tags: Erratum Source Type: research

Gastroesophageal reflux disease
No abstract available (Source: Gastroenterology Nursing)
Source: Gastroenterology Nursing - March 1, 2019 Category: Nursing Tags: Departments: Focus on Clinical Assessment Source Type: research

Co-existing pediatric ureteropelvic junction obstruction and vesicoureteric reflux: Prevalence and implications
Conclusion: The prevalence of VUR was 25.9% in this study and 33.3% in ≤1 year age group. There was a loss of function in delayed presenters with associated ipsilateral VUR. There was delayed drainage postpyeloplasty in patients with VUR. A preoperative voiding cystourethrogram should be done in children <1 year age before pyeloplasty so that associated VUR if detected can be concurrently managed along with pyeloplasty and preserve nephrons affected by the dual pathology. (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - March 1, 2019 Category: Surgery Authors: Shalini Hegde Prema Menon Katragadda Lakshmi Narasimha Rao Source Type: research

Long-Term Effectiveness of Antireflux Surgery in Esophageal Atresia Patients
Conclusion In the long term, ARP is not effective in reducing GERD as measured as Ri in EA patients. The ARP group had significantly lower weight at 1 and 7 years of age than the non-ARP group, but this was not the case at the age of 15. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - March 1, 2019 Category: Surgery Authors: J önsson, Linus Dellenmark-Blom, Michaela Enoksson, Oskar Friberg, Lars G öran Gatzinsky, Vladimir Sandin, Anders Abrahamsson, Kate Tags: Original Article Source Type: research

[Barrett-Screening: Rational, current concepts and perspectives].
ockel I Abstract Though showing an increasing incidence over the past 20 years, esophageal adenocarcinoma (EAC) remains a rather uncommon cancer (i. e., compared to colorectal and gastric cancer). Once detected, the prognosis of this cancer entity is still very poor. Hence, in spite of some unfavorable prerequisites to systematic screening, the development of a screening concept for Barrett's esophagus (BE) and EAC seems worthwhile. Nowadays, screening for BE and EAC is based on conventional endoscopy, mostly conducted individually in patients with reflux complaints (gastroesophageal reflux disease-GERD). B...
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Weismüller J, Thieme R, Hoffmeister A, Weismüller T, Gockel I Tags: Z Gastroenterol Source Type: research

Peroral endoscopic myotomy versus pneumatic dilation - result from a retrospective study with 1-year follow-up.
Abstract BACKGROUND AND AIMS:  On the basis of lesser rates of major adverse events and a short-term efficacy as Heller's myotomy, there is a growing enthusiasm in favor of peroral endoscopic myotomy (POEM), whereas study comparing POEM and pneumatic dilatation (PD) is quite rare. The aim of this study was to evaluate the efficacy of POEM and PD in Chinese achalasia patients in a retrospectively designed study. METHODS:  Patients with achalasia, who underwent either PD (n = 26) or POEM (n = 40) were retrospectively recruited from September 2010 through March 2016 at a single tertiary cente...
Source: Zeitschrift fur Gastroenterologie - March 1, 2019 Category: Gastroenterology Authors: Zheng Z, Zhao C, Su S, Fan X, Zhao W, Wang B, Jin H, Zhang L, Wang T, Wang B Tags: Z Gastroenterol Source Type: research