Eosinophilic esophagitis: Current concepts in diagnosis and treatment.
-Mindiola A Abstract Eosinophilic esophagitis is an immune-allergic pathology of multifactorial etiology (genetic and environmental) that affects both pediatric and adult patients. Its symptoms, which include heartburn, regurgitation, and esophageal stenosis (with dysphagia being more frequent in eosinophilic esophagitis in young adults and children), are similar to those of gastroesophageal reflux disease, causing delays in diagnosis and treatment. Although endoscopic findings such as furrows, esophageal mucosa trachealization, and whitish exudates may suggest its presence, this diagnosis should be confirmed hist...
Source: World Journal of Gastroenterology : WJG - August 28, 2019 Category: Gastroenterology Authors: Gómez-Aldana A, Jaramillo-Santos M, Delgado A, Jaramillo C, Lúquez-Mindiola A Tags: World J Gastroenterol Source Type: research

Internal hernia following laparoscopic roux-en-y gastric by-pass: indicative factors for early repair
CONCLUSION: The presence of recurrent abdominal pain is one of the main indicators for the diagnosis of IH after LRYGB. Patients operated at an early stage, even with negative imaging tests for this disease, benefited from rapid and simple procedures without major complications.RESUMO CONTEXTO: H érnia interna (HI) após bypass gástrico em Y de Roux laparoscópico (BGYRL) é uma complicação importante que desafia o cirurgião devido à sua apresentação inespecífica e necessidade de reparo precoce. Um diagnóstico e intervençã...
Source: Arquivos de Gastroenterologia - August 27, 2019 Category: Gastroenterology Source Type: research

Historical perspective of gastroesophageal reflux disease clinical treatment
CONCLUSION: Recognizing the historical evolution of GERD management can help care providers to better understand therapeutic options for their patients, as well as focus on unmet needs that deserve further attention. PPIs are still the first choice therapy, with good evidence in favor of their efficacy, despite some safety concerns. However, as with any medical intervention, it is recommended to prescribe PPIs for patients with clear indication, using adequate dosing and monitoring for adverse events.RESUMO CONTEXTO: A doen ça do refluxo gastroesofágico (DRGE) é uma das doenças gastrointestinais...
Source: Arquivos de Gastroenterologia - August 27, 2019 Category: Gastroenterology Source Type: research

Reaction to articles on high resolution manometry, the length of the lower esophageal sphincter and the diagnosis of gastroesophageal reflux disease
CONCLUSION: Recognizing the historical evolution of GERD management can help care providers to better understand therapeutic options for their patients, as well as focus on unmet needs that deserve further attention. PPIs are still the first choice therapy, with good evidence in favor of their efficacy, despite some safety concerns. However, as with any medical intervention, it is recommended to prescribe PPIs for patients with clear indication, using adequate dosing and monitoring for adverse events.RESUMO CONTEXTO: A doen ça do refluxo gastroesofágico (DRGE) é uma das doenças gastrointestinais...
Source: Arquivos de Gastroenterologia - August 27, 2019 Category: Gastroenterology Source Type: research

In defense of four decades of esophageal function tests. reply to reaction to articles on high resolution manometry, the length of the lower esophageal sphincter and the diagnosis of gastroesophageal reflux disease
CONCLUSION: Recognizing the historical evolution of GERD management can help care providers to better understand therapeutic options for their patients, as well as focus on unmet needs that deserve further attention. PPIs are still the first choice therapy, with good evidence in favor of their efficacy, despite some safety concerns. However, as with any medical intervention, it is recommended to prescribe PPIs for patients with clear indication, using adequate dosing and monitoring for adverse events.RESUMO CONTEXTO: A doen ça do refluxo gastroesofágico (DRGE) é uma das doenças gastrointestinais...
Source: Arquivos de Gastroenterologia - August 27, 2019 Category: Gastroenterology Source Type: research

[Ineffective esophageal motility].
Abstract Ineffective esophageal motility is the most frequent esophageal motility disorder. It is currently defined by 50% or more ineffective esophageal contractions and a normal lower esophageal sphincter relaxation on high-resolution esophageal manometry. Although reported in patients without symptoms, it is typically associated with gastro-esophageal reflux disease, and might be a consequence of the reflux. Ineffective esophageal motility can account for a certain degree of dysphagia, and is associated with a more severe gastroesophageal reflux. Todate, no specific endoscopic or pharmacologic treatment is avai...
Source: Presse Medicale - August 27, 2019 Category: General Medicine Authors: Leandri C, Guillaumot MA, Dohan A, Leconte M, Coriat R, Chaussade S, Barret M Tags: Presse Med Source Type: research

Risk factors predisposing to cardia gastric adenocarcinoma: Insights and new perspectives
The etiology of adenocarcinoma of the cardia and the gastroesophageal junction (GEJ) is not known and is doubted. It is thought that cardia gastric adenocarcinoma (CGA) is distinct from adenocarcinomas located in the esophagus or distal stomach, both epidemiologically and biologically. Moreover, CGA is often identified in the advanced stage having a poor prognosis. In this paper, we would like to ascertain the possible role of GC family history, lifestyle, demographics, gastroesophageal reflux disease,Helicobacter pylori infection, and multiple genetic and epigenetic risk factors as well as several predisposing conditions ...
Source: Cancer Medicine - August 25, 2019 Category: Cancer & Oncology Authors: Esmat Abdi, Saeid Latifi ‐Navid, Saber Zahri, Abbas Yazdanbod, Farhad Pourfarzi Tags: REVIEW Source Type: research

Issue Highlights
Dysphagia is one of the most common postoperative symptoms reported by patients following antireflux surgery. A recent paper in Clinical Gastroenterology and Hepatology provided a comprehensive overview of recent advances in the management of esophageal motility disorders in general.1 In this issue, Hasak and colleagues2 report outcomes of adults who developed dysphagia following antireflux surgery for treatment of gastroesophageal reflux disease. Of 157 patients, 64.3% reported postoperative dysphagia; about half reported clinically significant dysphagia, defined as a score ≥ 2 on a 5-point Likert scale. (Source: Clini...
Source: Clinical Gastroenterology and Hepatology - August 23, 2019 Category: Gastroenterology Authors: Ziad Gellad Tags: Issue highlights Source Type: research

Can the Reflux Finding Score and Reflux Symptom Index Be Used to Evaluate the Severity of Esophagitis in Children?
Laryngopharyngeal reflux (LPR), a growing issue in ear, nose, and throat (ENT) and pediatric medicine, is the backflow of stomach contents into the laryngopharynx. Patients present with frequent upper and/or lower respiratory tract infections and coughs, associated with acid- and pepsin-mediated injury to the mucosae of the larynx and pharynx. LPR is associated with rhinosinusitis, laryngitis, pneumonia, and asthma. Children with LPR often fail to exhibit classic gastroesophageal reflux disease symptoms, or such symptoms may be intermittent. (Source: Journal of Voice)
Source: Journal of Voice - August 23, 2019 Category: ENT & OMF Authors: Meltem Korkut Ugras, Muzeyyen Dogan, D. Yavuz Selim Pata, Ferda Ozkan Source Type: research

The influence of gastroesophageal reflux symptoms on patient satisfaction after sleeve gastrectomy
Sleeve gastrectomy has become the most common procedure performed for weight loss. But emerging data indicate that this procedure can result in lifestyle-limiting gastroesophageal reflux disease. The influence of these gastroesophageal reflux disease symptoms on patient satisfaction with the procedure has not been explored. (Source: Surgery)
Source: Surgery - August 22, 2019 Category: Surgery Authors: Inga A. Van Wieren, Jyothi R. Thumma, Nabeel R. Obeid, Oliver A. Varban, Justin B. Dimick Source Type: research

The Case | An 82-year-old male with worsening kidney function
An 82-year-old male, with a history of bowel cancer with partial colectomy, gastroesophageal reflux disease, remote partial gastrectomy for peptic ulcer disease, and no documented prior kidney disease, presents with several months of fatigue and subacute decline in kidney function. He had no history of diabetes, hypertension, kidney stones, or prior urinary tract infections. He denied use of nonsteroidal anti-inflammatory agents, herbal medications, and recent antibiotics. There was no family history of renal disease. (Source: Kidney International)
Source: Kidney International - August 21, 2019 Category: Urology & Nephrology Authors: George L. Worthen, Laurette Geldenhuys, Karthik K. Tennankore Tags: Make Your Diagnosis Source Type: research

Total gastrectomy in systemic scleroderma when anti-reflux surgery is not viable: a case report
DiscussionWe suggest an open gastrectomy with roux-en-Y anastomosis as an alternative to the Nissen fundoplication for patients with connective tissue disease that develop terminal pulmonary consequences and require a lung transplant. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - August 20, 2019 Category: Surgery Source Type: research

The outcomes of fundoplication and gastrostomy in neurologically impaired children in a tertiary care hospital in Saudi Arabia.
Conclusions: Fundoplication with GT is effective in reducing hospital admissions and emergency department visits from GER and seizures in NI children. Because of high mortality within a year of fundoplication and GT in DNR children, anti-reflux medications with GT might be an alternative. PMID: 31423518 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - August 20, 2019 Category: Middle East Health Tags: Saudi Med J Source Type: research

Correlates of gastroenterology health-services utilization among patients with gastroesophageal reflux disease: a large database analysis
ConclusionsPatient and physician ’s characteristics were related to high utilization of gastroenterology services among GERD patients. The associations with age and country of birth might reflect more severe disease. The regional differences warrant further research and interventions at the district level. Training in gastroenter ology of primary care physicians without a board certification is warranted. (Source: Israel Journal of Health Policy Research)
Source: Israel Journal of Health Policy Research - August 20, 2019 Category: International Medicine & Public Health Source Type: research

Higher Esophageal Symptom Burden in Obese Subjects Results From Increased Esophageal Acid Exposure and Not From Dysmotility
We examined the relationships among symptom burden, EMD, acid exposure time (AET), symptom association probability, and body mass index (BMI). (Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - August 20, 2019 Category: Gastroenterology Authors: Benjamin D. Rogers, Amit Patel, Dan Wang, Gregory S. Sayuk, C. Prakash Gyawali Source Type: research

Laparoscopic Hiatal Hernia Repair Followed by Transoral Incisionless Fundoplication With EsophyX Device (HH + TIF): Efficacy and Safety in Two Community Hospitals.
This study examined the safety and efficacy when repairing defects in 2 anatomical structures (hiatus and lower esophageal sphincter) in a concomitant set of procedures in patients with hiatal hernias between 2 and 5 cm. Methods. Prospective data were collected from 99 patients who underwent hiatal hernia repair followed immediately by the TIF procedure (HH + -TIF). GERD-HRQL (Health-Related Quality of Life), RSI (Reflux Symptom Index), and GERSS (Gastroesophageal Reflux Symptom Score) questionnaires were administered before the procedure and mailed at 6 and 12 months. Results. Ninety-nine patients were enrolled, and all w...
Source: Surgical Innovation - August 20, 2019 Category: Surgery Authors: Janu P, Shughoury AB, Venkat K, Hurwich D, Galouzis T, Siatras J, Streeter D, Korman K, Mavrelis G, Mavrelis P Tags: Surg Innov Source Type: research

Gastro-oesophageal reflux disease symptoms and associated risk factors among medical students, Saudi Arabia
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - August 19, 2019 Category: General Medicine Tags: International Journal of General Medicine Source Type: research

Associations among gastroesophageal reflux disease, mental disorders, sleep and chronic temporomandibular disorder: a case-control study.
Abstract BACKGROUND: Temporomandibular disorders (TMDs) are a family of pain-related disorders associated with impaired function in the jaw, temporomandibular joint and muscles of mastication. Our objectives were to evaluate the association between chronic TMD and gastresophageal reflux disease (GERD) and to determine whether mental disorders or undermined sleep mediates this association. METHODS: We conducted a case-control study involving 1522 consecutive adult patients with chronic TMD and 1522 matched controls from 2 hospitals in China. All participants were aged between 18 and 70 years and were recruited...
Source: cmaj - August 19, 2019 Category: General Medicine Authors: Li Y, Fang M, Niu L, Fan Y, Liu Y, Long Y, Liu X, Tay FR, Chen J Tags: CMAJ Source Type: research

Gastric Acid and Pepsin Work Together in Simulated Gastric Acid Inhalation Leading to Pulmonary Fibrosis in Rats.
CONCLUSIONS The study demonstrates that aspiration of gastric contents can cause pulmonary fibrosis, and mixed aspiration of pepsin and gastric fluid can accelerate this process. This study provides strong evidence in support of a potential association between human GERD and IPF. PMID: 31419218 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - August 17, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Managing End-Stage Renal Disease: An Alphabetized Mnemonic Strategy
The objective of this article is to provide a structured and applicable approach to managing ESRD that is up-to-date and evidence based. To achieve this objective, we created an alphabetized mnemonic and synthesized our discussion to address Anemia, Bone health, Cardiovascular issues, vitamin D deficiency, Electrolytes imbalances, Fluid overload, and Gastroesophageal reflux in patients with ESRD. (Source: The Journal for Nurse Practitioners)
Source: The Journal for Nurse Practitioners - August 16, 2019 Category: Nursing Authors: Mohamed Toufic El Hussein, Lauren Kilfoil Tags: Feature Article Source Type: research

Relevance between Helicobacter pylori Infection and Non-Alcoholic Fatty Liver Disease in Birjand, Iran.
Authors: Mohammadifard M, Saremi Z, Rastgoo M, Akbari E Abstract There is evidence that infection by H. pylori can have a critical proportion in the development of hepatocyte injury and both noncancerous and malignant liver conditions including non-alcoholic fatty liver disease (NAFLD). This is attributed to several mechanisms, the most important one being the toxic products of the bacterium H. pylori and oxidative injury for hepatocytes which promotes hepatic injury. The present research was aimed at determining the association between H. pylori infection and the prevalence of NAFLD in Birjand, Iran. Two groups we...
Source: Journal of Medicine and Life - August 15, 2019 Category: General Medicine Tags: J Med Life Source Type: research

[Pharyngeal acid load and different functional endoscopy findings].
Authors: Michel F, Dannesberger R, Stroh T, Fritsche R, Ahrens P Abstract The findings of functional endoscopy (upper esophageal sphincter insufficiency, cardia insufficiency, esophagitis, gastric heterotopia, axial sliding hernia, and visible aerosols) can be traced back to pharyngeal acid exposure by oropharyngeal pH measurement. Significantly increased pharyngeal acid loads are seen in gastric heterotopy and axial sliding hernia. For all measured statistics, the pharyngeal acid load is in the pathological or even very pathological range. The value of functional endoscopy in the context of laryngopharyngeal reflu...
Source: HNO - August 14, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Long-Term Results After Laparoscopic Sleeve Gastrectomy with Concomitant Posterior Cruroplasty: 5-Year Follow-up
AbstractBackgroundHiatal hernia (HH) repair during laparoscopic sleeve gastrectomy (LSG) has been advocated to reduce the incidence of postoperative gastroesophageal reflux disease (GERD) and/or intrathoracic migration (ITM). The necessity of intraoperative repair in asymptomatic patients is still controversial. Previous, mid-term results of a prospective, comparative study evaluating posterior cruroplasty concomitant with LSG (group A 48 patients with simple vs. group B 48 reinforced with bioabsorbable mesh) confirmed the safety and effectiveness of simultaneous procedures. Present aim was to report the 60  months fo...
Source: Journal of Gastrointestinal Surgery - August 13, 2019 Category: Surgery Source Type: research

Novel insights into the Dispersed and Acid-mediated Surface Modification of the Carbon Nanofibers
Publication date: Available online 6 August 2019Source: Materials Chemistry and PhysicsAuthor(s): Kamini Turan, Prabhsharan Kaur, Dinesh Manhas, Jadab Sharma, Gaurav VermaCarbon nanofibers (CNF) are the state of art materials owing to their special morphological features. In the pristine form, they exhibit strong van der Waals interactions which keep them agglomerated. The actual potential of these nanofibers could be realized once these are unbundled. In this work, CNF have been dispersed with Triton X-100 during ultrasonication, and further functionalized using 3:1 mixture of H2SO4 and HNO3 via reflux method. The effects...
Source: Materials Chemistry and Physics - August 9, 2019 Category: Materials Science Source Type: research

Cost-utility analysis of a ‘vonoprazan-first’ strategy versus ‘esomeprazole- or rabeprazole-first’ strategy in GERD
ConclusionsVonoprazan-first strategy increased QALYs and appeared to be cost-effective for GERD patients compared with the esomeprazole- or rabeprazole-first strategies. (Source: Journal of Gastroenterology)
Source: Journal of Gastroenterology - August 8, 2019 Category: Gastroenterology Source Type: research

Clinico-radiologic Features of Lung Disease Associated with Aspiration Identified on Lung Biopsy.
CONCLUSIONS: Aspiration can occur in the absence of subjective or demonstrable swallowing difficulties and manifest a broad spectrum of clinico-radiologic presentations. PMID: 31398348 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - August 6, 2019 Category: Respiratory Medicine Authors: Ryu AJ, Navin PJ, Hu X, Yi ES, Hartman TE, Ryu JH Tags: Chest Source Type: research

Recurrent Febrile Urinary Tract Infections and Renal Scarring
In this issue of JAMA Pediatrics, Shaikh et al continue to shed light on important aspects of urinary tract infections (UTIs) in children based on data gleaned from the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) and Careful Urinary Tract Infection Evaluation (CUTIE) trials. The study by Shaikh et al addresses the likelihood of new renal scars developing after a first febrile UTI and after recurrent UTIs. Three decades ago, the pioneering group in Sweden identified a slight increase in renal scarring from the first UTI to the second and from the second to the third; only after 3 UTIs did the rat...
Source: JAMA Pediatrics - August 5, 2019 Category: Pediatrics Source Type: research

Gastroesophageal Reflux Disease in a Patient With BMI 30 kg/m2 and Previous Endoscopic Vertical Gastroplasty: Indication for a One Anastomosis Gastric Bypass
Publication date: Available online 3 August 2019Source: Cirugía Española (English Edition)Author(s): Jaime Ruiz-Tovar, Miguel Angel Carbajo, Jose Maria Jimenez, Javier Ortiz-de-Solorzano, Maria Jose Castro (Source: Cirugia Espanola)
Source: Cirugia Espanola - August 3, 2019 Category: Surgery Source Type: research

Omeprazole-Induced Dysbiosis Impacts Bile Acid Metabolism In Mice And Humans
Background and Aims: Proton pump inhibitors (PPIs) such as omeprazole are gastric acid-suppressing agents that are used to treat gastroesophageal reflux disease and peptic ulcers. In contrast, PPIs are also associated with gut microbiota dysbiosis and increased cardiovascular disease risk. However, proof of a causal link between PPI use, dysbiosis and cardiovascular disease is missing. (Source: Atherosclerosis)
Source: Atherosclerosis - August 3, 2019 Category: Cardiology Authors: A.G. Lopez Manosalva, T. Yntema, L. Chen, S. Garmaeva, S. Hu, M. Koster, M. Koehorst, M.H. Hofker, A. Vich, F. Kuipers, J. Fu, D. Koonen Tags: E-poster session Source Type: research

Gastroesophageal reflux disease in a patient with a BMI of 30 kg/m2 and previous endoscopic sleeve gastroplasty: Indication for a one-anastomosis gastric bypass.
-Barajas JM PMID: 31387725 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)
Source: Cirugia eEspanola - August 3, 2019 Category: Surgery Authors: García Ruiz de Gordejuela A, Vilallonga Puy R, Roriz da Silva R, Fort López-Barajas JM Tags: Cir Esp Source Type: research

A Video Case Report of Gastric Perforation Following Endoscopic Sleeve Gastroplasty and its Surgical Treatment
ConclusionESG is a feasible endobariatric option, but complications like gastric perforation can occur. For such complication, immediate surgical treatment is indicated. (Source: Obesity Surgery)
Source: Obesity Surgery - August 2, 2019 Category: Surgery Source Type: research

A Case of Burning Throat Pain
Throat pain is a common complaint in the emergency department. The related diagnoses are varied, from simple gastroesophageal reflux disease to catastrophic aortic dissection. This case highlights the importance of pertinent patient history and frequent reassessments in order to recognize the latter. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - August 1, 2019 Category: Emergency Medicine Authors: Alexis L. Cates, Theo Leriotis, Joseph Herres Tags: Clinical Communications: Adult Source Type: research

Laparoscopic Roux-en-Y Gastric Bypass After Gastroesophageal Reflux Disease Surgical Procedure: Analysis of 85 Consecutive Patients with Pre- and Post-Operative Endoscopy Control
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - August 1, 2019 Category: Surgery Authors: Giorgio Baretta Ahmad Essam Al-Mulla Marco Antonio Gimenez Lopes Rafael Schimidt Feistler Maria Paula Carlini Cambi Marcelo de Paula Loureiro Source Type: research

Laparoscopic Roux-en-Y Gastric Bypass After Gastroesophageal Reflux Disease Surgical Procedure: Analysis of 85 Consecutive Patients with Pre- and Post-Operative Endoscopy Control
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic and Advanced Surgical Techniques)
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - August 1, 2019 Category: Surgery Authors: Giorgio Baretta Ahmad Essam Al-Mulla Marco Antonio Gimenez Lopes Rafael Schimidt Feistler Maria Paula Carlini Cambi Marcelo de Paula Loureiro Source Type: research

Management of Refractory Gastroesophageal Reflux Disease #377
Journal of Palliative Medicine,Volume 22, Issue 8, Page 998-1000, August 2019. (Source: Journal of Palliative Medicine)
Source: Journal of Palliative Medicine - August 1, 2019 Category: Palliative Care Authors: Adam Greenfield Tara Cook Jennifer Pruskowski Source Type: research

Misdiagnosis and pitfalls in Panayiotopoulos syndrome
Publication date: September 2019Source: Epilepsy & Behavior, Volume 98, Part AAuthor(s): Alessandro Graziosi, Noemi Pellegrino, Vincenzo Di Stefano, Umberto Raucci, Anna Luchetti, Pasquale ParisiAbstractPanayiotopoulos syndrome (PS) is a frequent (6% among children of 1–15 years) and benign epileptic syndrome, characterized by predominantly autonomic symptoms (emesis, pallor, flushing, cyanosis, mydriasis/miosis, cardiorespiratory and thermoregulatory alterations, incontinence of urine and/or feces, hypersalivation, and modifications of intestinal motility) associated with simple motor focal seizures, which can...
Source: Epilepsy and Behavior - July 30, 2019 Category: Neurology Source Type: research

The Mpemba effect in spin glasses is a persistent memory effect [Applied Physical Sciences]
The Mpemba effect occurs when a hot system cools faster than an initially colder one, when both are refrigerated in the same thermal reservoir. Using the custom-built supercomputer Janus II, we study the Mpemba effect in spin glasses and show that it is a nonequilibrium process, governed by the coherence... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - July 30, 2019 Category: Science Authors: Marco Baity–Jesi, Enrico Calore, Andres Cruz, Luis Antonio Fernandez, Jose Miguel Gil–Narvion, Antonio Gordillo–Guerrero, David Iniguez, Antonio Lasanta, Andrea Maiorano, Enzo Marinari, Victor Martin–Mayor, Javier Moreno–Gord Tags: Physical Sciences Source Type: research

Periprocedural Considerations for Patients with Gastric Electrical Stimulators
ConclusionsAvailable data suggests GES is a technology with increasing prevalence. When patients with an implanted GES device present for periprocedural care, the anesthesia staff must consider the device when planning for the procedure. Topics addressed include general anesthetic considerations, nerve localization, radiation exposure, electrocautery, diathermy, emergency external defibrillation, and MRI compatibility. (Source: Neuromodulation: Technology at the Neural Interface)
Source: Neuromodulation: Technology at the Neural Interface - July 29, 2019 Category: Biotechnology Authors: Weston Case Nadherny, Brooke Anderson, Alaa Abd ‐Elsayed Tags: Review Article Source Type: research

Activin A-mediated epithelial de-differentiation contributes to injury repair in an in vitro gastrointestinal reflux model.
In this study, we show that in response to bile salt and acidified media (pH 4) exposure, emulating the milieu to which the distal esophagus is exposed during gastroesophageal reflux, long-term treated, tolerant esophageal keratinocytes exhibit increased ActA secretion and a pro-inflammatory cytokine signature. Furthermore, we noted increased motility and expression of the stem cell markers SOX9, LGR5 and DCLK1 supporting the notion that repair mechanisms were activated in the bile salt/acid-tolerant keratinocytes. Additionally, these experiments demonstrated that de-differentiation as characterized by the induction of YAP...
Source: Cytokine - July 29, 2019 Category: Molecular Biology Authors: Roudebush C, Catala-Valentin A, Andl T, Le Bras GF, Andl CD Tags: Cytokine Source Type: research

Misdiagnosis and pitfalls in Panayiotopoulos syndrome.
Abstract Panayiotopoulos syndrome (PS) is a frequent (6% among children of 1-15 years) and benign epileptic syndrome, characterized by predominantly autonomic symptoms (emesis, pallor, flushing, cyanosis, mydriasis/miosis, cardiorespiratory and thermoregulatory alterations, incontinence of urine and/or feces, hypersalivation, and modifications of intestinal motility) associated with simple motor focal seizures, which can be followed by secondary generalization. Panayiotopoulos syndrome can be extremely insidious, because it can mimic several condition, such as gastroenteritis, gastroesophageal reflux disease, en...
Source: Epilepsy and Behaviour - July 29, 2019 Category: Neurology Authors: Graziosi A, Pellegrino N, Di Stefano V, Raucci U, Luchetti A, Parisi P Tags: Epilepsy Behav Source Type: research

Highly Efficient Phosphorescence From Cyclometallated Iridium(III) Compounds: Improved Syntheses of Picolinate Complexes and Quantum Chemical Studies of Their Electronic Structures
We report a new method to make heteroleptic cyclometallated iridium(III) complexes that employs 1,2-dimethoxyethane (DME) instead of the commonly used 2-ethoxyethanol for the addition of ancillary ligands to chloro-bridged dimeric iridium species. Thus, picolinic acid was quickly and cleanly added to [(F2ppy)2Ir(Cl)]2 (where F2ppy = 2-(4’,6’-difluorophenyl)pyridinato)) with base under DME reflux to afford (F2ppy)2Ir(picolinate) (FIrpic) in excellent yield. The high purity of the products obviates the need for further purification, an improvement over the common route in which column chromatography is required. ...
Source: Inorganica Chimica Acta - July 28, 2019 Category: Chemistry Source Type: research

Efficacy of the four weeks treatment of omeprazole plus mosapride combination therapy compared with that of omeprazole monotherapy in patients with proton pump inhibitor-refractory gastroesophageal reflux disease: a randomized controlled trial
(Source: Clinical and Experimental Gastroenterology)
Source: Clinical and Experimental Gastroenterology - July 26, 2019 Category: Gastroenterology Tags: Clinical and Experimental Gastroenterology Source Type: research

Ameliorating Effects of Transcutaneous Electrical Acustimulation Combined With Deep Breathing Training on Refractory Gastroesophageal Reflux Disease Mediated via the Autonomic Pathway
AimsTo investigate the effects and possible mechanisms of transcutaneous electrical acustimulation (TEA) combined with deep breathing training (DBT) on refractory gastroesophageal reflux disease (rGERD).MethodsTwenty ‐one patients with rGERD were recruited and randomly assigned to receive either only esomeprazole (ESO, 20 mg bid) (group A, n = 7), TEA + DBT + ESO (group B, n = 7), or sham‐TEA + DBT + ESO (group C, n = 7) in a four‐week study. The reflux diagnostic questionnaire (RDQ) score and heart rate variability (HRV) were recorded and evaluated at baseline and at the end of each treatment. Blood samples w...
Source: Neuromodulation: Technology at the Neural Interface - July 26, 2019 Category: Biotechnology Authors: Yue Yu, Ruiling Wei, Zhi Liu, Jiaqin Xu, Chao Xu, Jiande D. Z. Chen Tags: Clinical Research Source Type: research

Comparison of the efficacy of ranitidine and quince syrup on gastroesophageal reflux disease in children.
Abstract INTRODUCTION: Since the treatment of gastroesophageal reflux disease (GERD) symptoms in children is of the utmost importance, the current study is aimed to evaluating the efficacy of quince syrup and ranitidine in the management of pediatric patients with symptomatic GERD. METHODS AND MATERIALS: This double-blind, randomized clinical trial was performed on 96 children suspected of suffering from GERD. The patients referred to the gastrointestinal clinic of Ghaem Hospital, Iran, during 2017. The participants were randomly categorized into two groups (ranitidine and ranitidine plus quince syrup). The G...
Source: Complementary Therapies in Medicine - July 25, 2019 Category: Complementary Medicine Authors: Naeimi M, Kianifar H, Memariani Z, Kamalinejad M, Bijani A, Saghebi R, Gorji N Tags: Complement Ther Med Source Type: research

Salvage Options for Fundoplication Failure
AbstractPurpose of ReviewGastroesophageal reflux disease (GERD) affects millions of people worldwide. Many patients with medically refractory symptoms ultimately undergo antireflux surgery, most often with a laparoscopic fundoplication. Symptoms related to GERD may persist or recur. Revisional surgery is necessary in some patients.Recent FindingsA reoperative fundoplication is the most commonly performed salvage procedure for failed fundoplication. Although redo fundoplication has been reported to have increased risk of morbidity compared with primary cases, increasing experience with the minimally invasive approach to reo...
Source: Current Gastroenterology Reports - July 25, 2019 Category: Gastroenterology Source Type: research

Gravitational Autoreposition for Staged Closure of Omphaloceles
Conclusion GRAVITAS is a feasible method for staged closure of large omphaloceles when successful primary closure is deemed questionable. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - July 25, 2019 Category: Surgery Authors: Uecker, Marie Petersen, Claus Dingemann, Carmen Fortmann, Caroline Ure, Benno M. Dingemann, Jens Tags: Original Article Source Type: research

Detection of minimal mucosal esophageal lesions in non-erosive gastroesophageal reflux disease using optical enhancement plus optical magnification
Endosc Int Open 2019; 07: E979-E986 DOI: 10.1055/a-0953-1844 Background and study aims The aim of this study was to evaluate the diagnostic yield of endoscopy using optical enhancement (OE system) with optical magnification to predict reflux in non-erosive reflux disease (NERD) patients. Patients and methods A prospective, non-randomized, single-blind study was performed from September 2015 to January 2016. Participants suffered from gastroesophageal reflux disease (GERD) symptoms and were assigned to the NERD group or the non-reflux disease control group based on endoscopic findings and a 24-hour pH-imped...
Source: Endoscopy International Open - July 24, 2019 Category: Gastroenterology Authors: Robles-Medranda, Carlos Valero, Manuel Soria-Alc ívar, Miguel Puga-Tejada, Miguel Oleas, Roberto Ospina, Jesenia Alvarado-Escobar, Haydee Baquerizo-Burgos, Jorge Pitanga-Lukashok, Hannah Tags: Original article Source Type: research

Efficacy and Safety of AlbisD Compared With Omeprazole 20 mg in Patients With Non-erosive Reflux Disease: A Randomized, Open-label, Active-controlled, Pilot Study.
Conclusions: The efficacy and safety of AlibsD in treating NERD patients are not inferior to those of omeprazole. Therefore, AlbisD can be an alternative to PPIs for NERD. PMID: 31327222 [PubMed] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

Multicenter Prospective Study of Laparoscopic Nissen Fundoplication for Gastroesophageal Reflux Disease in Korea.
Authors: Park S, Park JM, Kim JJ, Lee IS, Han SU, Seo KW, Kwon JW Abstract Backgrounds/Aims: This multicenter study aims to evaluate the effect and feasibility of anti-reflux surgery compared with medical treatment for gastroesophageal reflux disease (GERD). Methods: Patients with GERD who were undergoing medical treatment with proton pump inhibitors for more than 8 weeks and those who were scheduled to undergo anti-reflux surgery were enrolled. Efficacy of pre-operative medical treatment was evaluated retrospectively and effect of anti-reflux surgery was prospectively evaluated at 1 week and 3 months after sur...
Source: Journal of Neurogastroenterology and Motility - July 23, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research