Impact of bronchiectasis on severe asthma: data from the "Severe Asthma Network Italy" (SANI) registry
Background: The presence of bronchiectasis in patients with severe asthma (SA) might be of clinical relevance, although data on epidemiology and characteristics of this population are scarce. In order to evaluate prevalence and impact of bronchiectasis on SA patients, a secondary analysis of the "Severe Asthma Network Italy" (SANI) registry was conducted.Methods: SANI is a web-based registry encompassing demographic, clinical, functional and inflammatory data of patients with SA aged>12 y.o., across 62 centers in Italy. SA is defined according to the latest ERS definition. Data recorded from September to Decem...
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Heffler, E. M., Aliberti, S., Sirena, C., DAdda, A., Ferri, S., Crimi, N., Latorre, M., Senna, G., Paggiaro, P., Blasi, F., Canonica, G. W. Tags: Clinical Problems Source Type: research

Discoordination of Autonomic Support of Functions in the Pathogenesis Gastroesophageal Reflux Disease
A cross-sectional study performed on a continuous sample of 32 patients (mean age 46.36 ±3.31 years) with gastroesophageal reflux disease and excess body weight showed that the disturbance of sympathetic/parasympathetic relationships, disruption of segmental and compensatory increase in the suprasegmental mechanisms of autonomic regulation determines the course of gastroesophageal ref lux disease in these patients. (Source: Bulletin of Experimental Biology and Medicine)
Source: Bulletin of Experimental Biology and Medicine - November 18, 2018 Category: Biology Source Type: research

The first one-pot synthesis of undoped and Eu doped β-NaYF4 nanocrystals and their evaluation as efficient dyes for nanomedicine.
The first one-pot synthesis of undoped and Eu doped β-NaYF4 nanocrystals and their evaluation as efficient dyes for nanomedicine. Mater Sci Eng C Mater Biol Appl. 2019 Jan 01;94:26-34 Authors: Mnasri W, Ben Tahar L, Boissière M, Abi Haidar D, Ammar S Abstract Polygonal-shaped about 75 nm sized and highly crystallized Eu3+-doped β-NaYF4 particles were directly prepared under mild conditions using the polyol process. A set of operating parameters were optimized for such a purpose. A conventional heating under reflux for 30 min of a mixture of Y(III) and Eu(III) acetate, ammonium flu...
Source: Appl Human Sci - November 16, 2018 Category: Physiology Authors: Mnasri W, Ben Tahar L, Boissière M, Abi Haidar D, Ammar S Tags: Mater Sci Eng C Mater Biol Appl Source Type: research

Effect of high ‐fat, standard, and functional food meals on esophageal and gastric pH in patients with gastroesophageal reflux disease and healthy subjects
ObjectivesTo investigate the effects of different test meals on esophageal and intragastric pH in patients with gastroesophageal reflux disease (GERD) and healthy subjects and to demonstrate the relationship between esophageal acid exposure (EAE) and gastric pH.MethodsWe enrolled patients with reflux esophagitis (RE;n = 15), nonerosive reflux disease (NERD;n = 12) and healthy subjects (n = 10). Four pH electrodes were used to monitor the pH of the distal esophagus, upper border of the lower esophageal sphincter, gastric fundus, and gastric body for 26 hours. Isocaloric and i...
Source: Journal of Digestive Diseases - November 15, 2018 Category: Gastroenterology Authors: Wen Juan Fan, Yuan Tao Hou, Xiao Hong Sun, Xiao Qing Li, Zhi Feng Wang, Meng Guo, Li Ming Zhu, Ning Wang, Kang Yu, Jing Nan Li, Mei Yun Ke, Xiu Cai Fang Tags: Original article Source Type: research

Longitudinal Assessment of Patient-reported Outcome Measures in Systemic Sclerosis Patients with Gastroesophageal Reflux Disease - Scleroderma Clinical Trials Consortium.
Abstract OBJECTIVE: Validated gastrointestinal (GI) symptoms scales are used in clinical practice to assess patient-reported GI involvement. We sought to determine whether University of California, Los Angeles (UCLA) GI Tract Questionnaire (GIT) 2.0 Reflux scale, Patient-Reported Outcomes Measurement Information System (PROMIS) Reflux scale, and the Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD) are sensitive to identifying changes in GI symptoms following therapeutic intervention in participants with systemic sclerosis (SSc) and gastroesophageal reflux disease (GERD). METHODS: Participants wi...
Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: McMahan ZH, Frech T, Berrocal V, Lim D, Bruni C, Matucci-Cerinic M, Smith V, Melsens K, Proudman S, Zhang J, Mendoza F, Woods M, Khanna D Tags: J Rheumatol Source Type: research

A 14-Month-Old Child With Gastroesophageal Reflux and Central Apnea
(Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - November 14, 2018 Category: Sleep Medicine Source Type: research

High Prevalence of Pathological Hydrogen Breath Tests in Patients with Functional Dyspepsia
Conclusion: We suggest that HBT should be considered in the clinical management of patients with suspected FD. In cases of positive HBTs, a potential causal therapy can be initiated.Digestion (Source: Digestion)
Source: Digestion - November 14, 2018 Category: Gastroenterology Source Type: research

Alcohol consumption and lung cancer risk: A pooled analysis from the International Lung Cancer Consortium and the SYNERGY study
ConclusionsWhether the non-monotonic associations we observed or the positive association between beer drinking and squamous cell carcinoma reflect real effects await future analyses and insights about possible biological mechanisms. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 14, 2018 Category: Cancer & Oncology Source Type: research

Acidic Pharyngeal Reflux Does Not Correlate with Symptoms and Laryngeal Injury Attributed to Laryngopharyngeal Reflux
AbstractBackgroundLaryngopharyngeal reflux (LPR) is suspected when the symptoms are attributed to the penetration of acidic gastroesophageal reflux (GER) into the larynx. However, the relationships between the intensity of LPR and symptoms and laryngeal injury have not been elucidated. Several factors confound the study of LPR, namely pH is monitored in the pharynx (pharyngeal reflux) but the pharyngeal acidity (pH) required to induce laryngeal injury is unknown, the GER origin of pharyngeal acid is not always established, and a recent treatment with proton pump inhibitors (PPI) confounds the analysis.AimsWe aimed to limit...
Source: Digestive Diseases and Sciences - November 14, 2018 Category: Gastroenterology Source Type: research

Isatin ‐SO3H coated on amino propyl modified magnetic nanoparticles (Fe3O4@APTES@isatin‐SO3H) as a recyclable magnetic nanoparticle for the simple and rapid synthesis of pyrano[2,3‐d] pyrimidines derivatives
Eco ‐friendly synthesis of pyrano[2,3‐d]pyrimidinone derivatives catalyzed isatin‐SO3H coated on amino propyl modified magneticnanoparticles in H2O:EtOH (1:1) is reported. Isatin ‐SO3H coated on amino propyl modified magnetic nanoparticles (Fe3O4@APTES@isatin ‐SO3H) is found to be a novel, efficient, and reusable magnetic nanocatalyst, and characterized by FT ‐IR, SEM, TEM, XRD, EDX, VSM, and TGA analysis. The magnetic nanocatalyst demonstrated outstanding performance in synthesis of pyrano[2,3‐d] pyrimidines derivativesvia one ‐pot three‐component reaction of various aromatic aldehydes 1, malononitrile 2...
Source: Applied Organometallic Chemistry - November 13, 2018 Category: Chemistry Authors: Sami Sajjadifar, Zohreh Gheisarzadeh Tags: FULL PAPER Source Type: research

Histologic similarities in children with eosinophilic esophagitis and proton pump inhibitor –responsive esophageal eosinophilia
Distinguishing between eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), and proton pump inhibitor (PPI)-responsive esophageal eosinophilia (PPI-REE) is difficult because symptoms overlap and there is no pathognomonic histologic feature for these disorders.1 Current EoE diagnostic guidelines define EoE as a clinicopathological condition characterized by symptoms of esophageal dysfunction and greater than 15 eosinophils per hpf (eos/hpf) in the esophageal mucosa after ruling out other etiologies as a cause of inflammation. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - November 13, 2018 Category: Allergy & Immunology Authors: Nathalie Nguyen, Anna Baumgarten, Benjamin L. Wright, Kelley E. Capocelli, Zhaoxing Pan, James J. Lee, Glenn T. Furuta, Joanne C. Masterson Tags: Letter to the Editor Source Type: research

Stenting in Palliation of Unresectable Esophageal Cancer
ConclusionsStenting is an effective procedure in relieving dysphagia in patients with unresectable malignant esophageal stenosis and is associated with low rate of postoperative and long-term complications. (Source: World Journal of Surgery)
Source: World Journal of Surgery - November 12, 2018 Category: Surgery Source Type: research

Germination of pollen grains in the esophagus of individuals with eosinophilic esophagitis
ConclusionAlteration of the mucosal barrier in EoE might cause the penetration of pollen grains into the esophageal tissues. In EoE patients, anatomopathological studies searching for intrusion to plant foods and pollen, and specific ‐guided diet and immunotherapy after plant structures detection in biopsies, might be effective.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - November 12, 2018 Category: Allergy & Immunology Authors: Alicia Armentia, Sara Mart ín Armentia, Rafael Álvarez‐Nogal, Blanca Martín Armentia, Manuel José Gayoso, Delia Fernández‐González Tags: Original Article ‐Clinical Mechanisms in Allergic Disease Source Type: research

Ingestible Contrast Agents for Gastrointestinal Imaging.
Abstract Gastrointestinal (GI) ailments cover a wide variety of diseases involving the esophagus, stomach, small intestine, large intestine or rectum. They bring about many inconveniences in daily life in chronic diseases and can even be life-threatening in acute cases. Rapid and safe detection approaches are essential for early diagnosis and timely managements. Contrast agent of GI imaging could enhance the contrast to distinguish the abnormal lesions from normal structures. CT and MRI are two important diagnostic tools for the evaluation of GI conditions. This review mainly involves several common GI diseases in...
Source: Chembiochem - November 12, 2018 Category: Biochemistry Authors: Yang X, Lovell JF, Zhang Y Tags: Chembiochem Source Type: research

Selective synthesis in microdroplets of 2-phenyl-2,3-dihydrophthalazine-1,4-dione from phenyl hydrazine with phthalic anhydride or phthalic acid.
Abstract Pyridazine derivatives are privileged structures because of their potential biological and optical properties. Traditional synthesis methods usually require acid or base as a catalyst under reflux conditions with reaction times ranging from hours to a few days or require microwave assistance to induce the reaction. Herein, we present the accelerated synthesis of a pyridazine derivative, 2-phenyl-2,3-dihydrophthalazine-1,4-dione, PDHP, in electrosprayed microdroplets containing 1:1 v/v mixture of phenyl hydrazine and phthalic anhydride or phthalic acid. This reaction occurred on the submillisecond timescal...
Source: Chemistry - November 11, 2018 Category: Chemistry Authors: Zare RN, Gao D, Jin F, Yan X Tags: Chemistry Source Type: research

The Dynamic and Transient Immune Microenvironment in Locally Advanced Esophageal Adenocarcinoma Post Chemoradiation
Conclusions: Collectively, these findings provide insights into the evolving immune landscape after chemoradiation and have significant implications for neoadjuvant trial designs that will combine radiotherapy with immune checkpoint inhibitors. (Source: Annals of Surgery)
Source: Annals of Surgery - November 10, 2018 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Short-Term Symptomatic Relief in Gastroesophageal Reflux Disease: A Comparative Study of Esomeprazole and Vonoprazan
ConclusionsThere were no substantial differences in the symptom relief between the two groups at any time point in this short-term study. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - November 10, 2018 Category: Gastroenterology Source Type: research

Covering the Cover
A US multicenter study develops a clinical model to estimate the pretest probability of abnormal acid reflux during pH monitoring in patients with refractory heartburn or suspected extraesophageal reflux symptoms who failed proton pump inhibitor therapy. (Source: Gastroenterology)
Source: Gastroenterology - November 9, 2018 Category: Gastroenterology Authors: Andrew T. Chan, Christopher S. Williams Tags: Covering the Cover Source Type: research

An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF- κB Signaling.
An Ethanolic Extract of Allium hookeri Root Alleviates Reflux Esophagitis and Modulates NF-κB Signaling. Evid Based Complement Alternat Med. 2018;2018:1834681 Authors: Nan L, Nam HH, Choo BK, Park JC, Kim DG, Lee JH, Moon KH Abstract Reflux esophagitis (RE) is a kind of gastroesophageal reflux disease, of which an esophageal inflammatory lesion is caused by the contents of the stomach and duodenum flowing back into the esophagus. Allium hookeri is a plant possessing both nutritional and medicinal properties. In our study, we investigated the inhibition effect of inflammation of A. hookeri root ex...
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Attitude and Knowledge of Saudi community pharmacists towards Use of Proton Pump Inhibitors
ConclusionCommunity pharmacists in Saudi Arabia usually recommend and prescribe PPIs to their patients. Most of them have some knowledge on PPIs indications and side effects. Managing OTC PPI use in the community pharmacy setting is necessary to promote both patient and medication safety. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

Sex-specific airway hyperreactivity and sex-specific transcriptome remodeling in neonatal piglets challenged with intra-airway acid.
Abstract Acute airway acidification is a potent stimulus of sensory nerves and occurs commonly with gastroesophageal reflux disease, cystic fibrosis and asthma. In infants and adults, airway acidification can acutely precipitate asthma-like symptoms, and treatment resistant asthma can be associated with gastroesophageal reflux disease. Airway protective behaviors, such as mucus secretion and airway smooth muscle contraction, are often exaggerated in asthma. These behaviors are manifested through activation of neural circuits. In some populations, the neural response to acid might be particularly important. For exa...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 8, 2018 Category: Cytology Authors: Reznikov LR, Liao YJ, Gu T, Davis KM, Kuan SP, Atanasova KR, Dadural JS, Collins EN, Guevara MV, Vogt K Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Preoperative gastric residual volumes in fasted patients measured by bedside ultrasound: a prospective observational study
The purpose of this prospective observational study was to measure gastric volumes in fasted patients using bedside gastric ultrasound. Patients presenting for non-emergency surgery underwent a gastric antrum assessment, using the two-diameter and free-trace methods to determine antral cross-sectional area (CSA). Gastric residual volume (GRV) was calculated using a validated formula. Univariate and multivariable analyses were performed to examine any potential relationships between ‘at risk’ GRVs (>100 ml) and patient factors. Two hundred and twenty-two successful scans were performed; of these 110 patients ...
Source: Anaesthesia and Intensive Care - November 7, 2018 Category: Anesthesiology Source Type: research

The Relationship Between Hiatal Hernia and Cricopharyngeus Muscle Dysfunction
AbstractAlthough the precise etiology of cricopharyngeus muscle (CPM) dysfunction (CPMD) is uncertain, many have hypothesized that a hypertrophied CPM may develop as a protective compensation against gastroesophageal reflux disease (GERD). The purpose of this investigation was to evaluate the association between CPMD and the presence of hiatal hernia (HH) in an attempt to elucidate the potential etiology of CPMD. The charts of individuals who underwent video fluoroscopic esophagrams between 01/01/14 and 10/30/16 were reviewed from an electronic database. A group of 50 subjects with reported HH were identified and age- and ...
Source: Dysphagia - November 7, 2018 Category: Speech-Language Pathology Source Type: research

Concept of histone deacetylases in cancer: Reflections on esophageal carcinogenesis and treatment.
Abstract Esophageal cancer (EC) presents a high mortality rate, mainly due to its aggressive nature. Squamous cell carcinoma is the most common histological type worldwide, though, a continuous increase in esophageal adenocarcinomas has been noted in the past decades. Common risk factors associated with EC include smoking, alcohol consumption, gastroesophageal reflux disease, Barrett's esophagus and obesity. In an effort to overcome chemotherapy resistance in oncology, it was discovered that histone acetylation/deacetylation equilibrium is altered in carcinogenesis, leading to changes in chromatin structure and al...
Source: World Journal of Gastroenterology : WJG - November 7, 2018 Category: Gastroenterology Authors: Schizas D, Mastoraki A, Naar L, Spartalis E, Tsilimigras DI, Karachaliou GS, Bagias G, Moris D Tags: World J Gastroenterol Source Type: research

Basal lower esophageal sphincter pressure in gastroesophageal reflux disease: An ignored metric in high-resolution esophageal manometry
AbstractManometry and 24-h pH interpretation have seldom been studied. Our aim was to study these parameters as gold standard in reflux disease and to identify predictors of pathological acid reflux. Retrospective case record review of all patients with reflux disease evaluated using endoscopy, manometry, and 24-h pH testing from 2010 to 2016. Patients were categorized using Johnson-DeMeester score into two groups —group I (score> 14.7, normal study) and group II (
Source: Indian Journal of Gastroenterology - November 6, 2018 Category: Gastroenterology Source Type: research

Medications With Depression as an Adverse Effect
To the Editor In a cross-sectional survey study, Dr Qato and colleagues found that the use of prescription medications with depression as a potential adverse effect was common. However, the authors did not take into account that most of the drugs described are used to treat conditions already linked to an increased risk of depressive symptoms. Although they investigated the relationship between hypertension and depression, they did not account for the association of depressive symptoms with pain (and subsequent use of pain killers), gastroesophageal reflux disorder (and subsequent use of gastrointestinal agents), or atopic...
Source: JAMA - November 6, 2018 Category: General Medicine Source Type: research

Failed Sleeve Gastrectomy: Single Anastomosis Duodenoileal Bypass or Roux-en-Y Gastric Bypass? A Multicenter Cohort Study
AbstractBackgroundSleeve gastrectomy (SG) has become the most performed bariatric procedure to induce weight loss worldwide. Unfortunately, a significant portion of patients show insufficient weight loss or weight regain after a few years.ObjectiveTo investigate the effectiveness of the single anastomosis duodenoileal (SADI) bypass versus the Roux-en-Y gastric bypass (RYGB) on health outcomes in morbid obese patients who had undergone SG previously, with up to 2  years of follow-up.MethodsFrom 2007 to 2017, 140 patients received revisional laparoscopic surgery after SG in four specialized Dutch bariatric hospitals. Da...
Source: Obesity Surgery - November 6, 2018 Category: Surgery Source Type: research

Avoiding routine postoperative voiding cystourethrogram: Predicting radiologic success for endoscopically treated vesicoureteral reflux.
CONCLUSIONS: We objectively demonstrated that IMM was a poor predictor of radiologic success and should be used with caution. In addition, the performance of a combined prediction model was inferior to the presence of a PUM alone. As such, selective use of postoperative VCUG may be guided solely by the presence of a PUM. PMID: 30407152 [PubMed - as supplied by publisher] (Source: Canadian Urological Association Journal)
Source: Canadian Urological Association Journal - November 5, 2018 Category: Urology & Nephrology Authors: Wang PZT, Abdelhalim A, Walia A, Wehbi E, Dave S, Khoury A Tags: Can Urol Assoc J Source Type: research

Reduction in Gastroesophageal Reflux Disease Symptoms Is Associated with Miso Soup Intake in a Population-Based Cross-Sectional Study: The Nagahama Study.
Authors: Mano F, Ikeda K, Sato T, Nakayama T, Tanaka D, Joo E, Takahashi Y, Kosugi S, Sekine A, Tabara Y, Matsuda F, Inagaki N, Nagahama Study Group Abstract Dietary habits and lifestyles are considered to affect the frequency of epigastric symptoms. In our previous study, we found that three amino acids in Japanese broth promoted gastric emptying. We hypothesized that a higher consumption of miso soup which was mainly composed of Japanese broth and miso paste would be associated with a lower frequency of epigastric symptoms. We conducted a cross-sectional study of the association between frequency of miso soup int...
Source: Journal of Nutritional Science and Vitaminology - November 3, 2018 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Gastroesophageal Reflux—Is It Uncommon in Indian Patients With Decompensated Liver Cirrhosis?
Publication date: Available online 5 October 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Uday Sanglodkar, Mayank Jain, M.J. Alexander, Jayanthi VenkataramanAbstractThe prevalence of reflux symptoms among Indian patients with decompensated cirrhosis is not known. We prospectively collected data using a predesigned questionnaire. Out of 200 patients recruited in the study, only 9.5% had reflux symptoms. None of the risk factors like smoking, alcohol and tobacco use; sex; age and severity of ascites correlated with patient symptoms. The present study highlights that GERD symptoms are infrequent among...
Source: Journal of Clinical and Experimental Hepatology - November 2, 2018 Category: Gastroenterology Source Type: research

Dual Delayed-Release Dexlansoprazole for Healing and Maintenance of Healed Erosive Esophagitis: A Safety Study in Adolescents
ConclusionsDexlansoprazole is safe and efficacious for healing EE and maintenance of healed EE in adolescents. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - November 2, 2018 Category: Gastroenterology Source Type: research

Clinical Validity and Reliability of the Malay Language Translations of Gastroesophageal Reflux Disease Questionnaire and Quality of Life in Reflux and Dyspepsia Questionnaire in a Primary Care Setting
Conclusions: GERDQ-M and QOLRAD-M are valid and reliable tools applicable in a primary care setting.Dig Dis (Source: Digestive Diseases)
Source: Digestive Diseases - November 1, 2018 Category: Gastroenterology Source Type: research

Proton Pump Inhibitor –Refractory Gastroesophageal Reflux Disease
This article reviews the definition, mechanisms, and management options for PPI-refractory GERD. (Source: Medical Clinics of North America)
Source: Medical Clinics of North America - November 1, 2018 Category: Primary Care Authors: Rena Yadlapati, Kelli DeLay Source Type: research

Remission of Barrett's Esophagus after Sleeve Gastrectomy, A Case Study
Background: Barrett's Esophagus (BE),common in individuals with gastroesophageal reflux disease (GERD), pre-disposes the affected individual to the potential development of intestinal metaplasia, dysplasia and esophageal adenocarcinoma. Due to physiologic changes incurred post Laparoscopic Sleeve Gastrectomy (LSG), there is an increased risk of BE development, or progression in patients with active GERD. Because of this, many surgeons consider a patient who has BE to be contraindicated for LSG surgery. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Stephanie Therrien, Daniel Jones Source Type: research

Minimally invasive conversion of sleeve gastrectomy to Roux-en-Y Gastric Bypass for Intractable Gastroesophageal Reflux Disease: Short Term Outcome
Background: Sleeve gastrectomy (SG) is considered definitive surgery for weight loss due to excellent short-term results. GERD has been reported to have a post-operative incidence between 3-50% and management remains controversial. This case series demonstrates our experience with intractable GERD management after SG with conversion of SG to Roux-en-Y gastric bypass (RYGB). (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Daniel G Davis, Lauren Kastner, Steven Leeds Source Type: research

Impact of bariatric surgery in anti-reflux medication use in patients with asthma and GERD
Background: There is an association between asthma and GERD (1). Although bariatric surgery has shown to reduce medication use in both comorbidities separately, there is limited research done in a population who have both asthma and GERD. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Gerardo G Davalos, Dana D Portenier, Hui-Jie Lee, Jennifer Ingram, Daniel D Guerron Source Type: research

Routine Hiatal Dissection and Repair Does Not Improve Short-Term Reflux After Vertical Sleeve Gastrectomy
Background: Gastroesophageal reflux disease (GERD) can be exacerbated or incited by VSG, potentially even leading to Barrett's esophagus. There is limited data regarding the impact of selective versus routine hiatal dissection and repair on GERD after VSG. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Mohan K Mallipeddi, Emma Gillette, Harveen K Sekhon, Desmond Huynh, Miguel A Burch, Scott A Cunneen, Edward H Phillips, Daniel Shouhed Source Type: research

Comparison between endoscopic and laparoscopic evaluation of hiatus hernia in patients undergoing weight loss surgery
Background: Currently, the advantages of pre-operative upper endoscopy in patients undergoing weight loss surgery remains controversial. Data suggests that patients with obesity have a high incidence of gastro-oesophageal reflux, oesophagitis and hiatus hernia (HH). Upper endoscopy findings may play an important role in operative planning. Currently, little evidence exists regarding the diagnostic sensitivity of upper endoscopy in detecting hiatus hernia. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Sabin J Warner-Smith, M Surg Pimlico Source Type: research

The Effect of Laparoscopic Sleeve Gastrectomy on Gastroesophageal Reflux Disease
Background: Gastroesophageal reflux disease (GERD) is a common condition in adults, affecting both quality of life and risk of developing esophageal cancer. Laparoscopic sleeve gastrectomy (LSG) has become a popular option for patients seeking operative management of morbid obesity, however it is unclear whether it may potentially worsen GERD symptoms. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Christina Poa, Collin Creange, Matthew J Pergamo, Christine J Ren-Fielding, George Fielding, Bradley F Schwack Source Type: research

Magnetic Sphincter Augmentation for Refractory Reflux Following Laparoscopic Sleeve Gastrectomy
Background: GERD can occur de novo in up to 30% of patients after Sleeve Gastrectomy (LSG). Most patients are successfully managed with lifestyle modifications and medical therapy. However, GERD refractory to medical therapy is difficult to manage with many patients requiring conversion Laparoscopic Roux En Y Gastric Bypass (LRYGB). Recently, Magnetic Sphincter Augmentation (MSA) has been proposed as a less morbid alternative for the relief of GERD. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Ryan D Horsley, Gordian U Ndubizu, Anthony Petrick Source Type: research

Laparoscopic Repair of Congenital Diaphragm Hernia with Gastric Bypass
Background: We are presenting a 35 year old patient with morbid obesity as well as symptoms of severe gastroesophageal reflux disease who, with preoperative imaging, was diagnosed with a large paraesophageal hernia. He underwent laparoscopic repair of the hernia as well as gastric bypass and was found at the time of surgery to have a large primary diaphragmatic hernia instead of a paraesophageal hernia. The defect did not appear to be either a Morgagni or Bochdalek hernia as it was centrally located in the diaphragm, just lateral to the left crus. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Kellen Hayes, Philip R Schauer Source Type: research

Type 3 Hiatal hernia complicating a mediogastric stenosis after gastric banding: cure of hiatal hernia and revision to Roux en Y Gastric Bypass
We present the case of a 54-year-old woman with a residual BMI of 35.4 kg/m2 after failure of gastric banding. She complained of persistent Gastro-Esophageal Reflux Disease (GERD) and dysphagia despite removal of the gastric band 3 years before. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Maud Robert, Arnaud Pasquer Source Type: research

Laparosocpic Nissen fundoplication with the excluded stomach for Recalcitrant GERD after a Roux en Y gastric bypass
Background: The patient is a 63 y/o white female who had undergone a roux en y gastric bypass 10 years prior. Patient had excellent weight loss, however the patient had significant reflux which was managed with PPI's. The patient 3 years ago underwent a lenthening of the roux limb for presumed bile reflux, however the patient continued to complain of significant reflux. She was then referred to us. The patient underwent a manometry which demonstrated good esophageal motility. Her impedence probe was significant for non acid reflux which was abnormal for total number of reflux episodes both supine and recumbent and associat...
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Rana Pullatt, Karl T Byrne, Benjamin White, Diana Axiotis, Molly Jones, Shelby Allen, Nina M Crowley Source Type: research

Roux-en-Y Gastric Bypass after Failed Lower Esophageal Sphincter Magnetic Augmentation Procedure
We present a video of a 49y/o female with a failed lower esophageal sphincter magnetic augmentation (LESM). The patient presented after referral to the bariatric practice after developing recurrent GERD (HRQL=13, on PPI), intermittent dysphagia, regurgitation and weight gain (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Darren Tishler, Andrea Stone, Beata Lobel, Pavlos K Papasavas Tags: Tuesday, November 13th1:30 pm--3:00 pm Source Type: research

When should endoscopy and 24h pH-test be done before bariatric surgery?
Background: The presence of gastroesophageal reflux disease (GERD) has an impact on the choice and outcomes of bariatric surgery. However, GERD diagnosis based solely on clinical evaluation has been proven to yield poor results in individuals with and without obesity. We studied the factors associated with abnormal 24h pH-test and the impact on diagnostic approach in patients with severe obesity. (Source: Surgery for Obesity and Related Diseases)
Source: Surgery for Obesity and Related Diseases - November 1, 2018 Category: Surgery Authors: Guilherme Mazzini, Daniel Navarini, Guilherme M Campos, Jad Khoraki, Fabio R Bar ão, Carlos A Madalosso, Richard R Gurski Source Type: research

Gastroesophageal reflux (gerd): a major factor in highly labile steroid-dependent asthma
In the setting of severe asthma with difficult to control symptoms, it is crucial to evaluate for other diagnoses and comorbidities in order to optimize management. In the case presented, sub-optimally treated GERD was identified as the driving force causing severe asthma symptoms. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: A. Meyer, S. Gupta, N. Rabinovitch, P. Hauk, J. Abbott Tags: M210 Source Type: research

Adverse drug reaction to all proton pump inhibitors except esomeprazole in medically complex pediatric patient
Proton-pump inhibitors (PPIs) are commonly used for treatment of gastroesophageal reflux disease (GERD). PPIs have a favourable safety profile; however, immediate and delayed hypersensitivity reactions have been described. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: L. Duan, S. Jeimy, S. Silver, J. Upton Tags: M056 Source Type: research

Prevalence of elevated exhaled nitric oxide in patients with chronic cough in a community setting
Physicians are frequently tasked with treating chronic cough (lasting longer than 8 weeks). Among patients who do not smoke cigarettes, the three primary etiologies of chronic cough are postnasal-drip syndrome, gastroesophageal reflux disease, and atypical asthma, which combined account for 92% of chronic cough. The measurement of exhaled nitric oxide in patients with chronic cough can identify patients who will likely improve with inhaled steroids versus those who will likely not, thereby mitigating the need for a trial of corticosteroids. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: W. Smith, W. Smith, L. Webb Tags: P112 Source Type: research

#12 Proposed randomised controlled feasibility trial of a novel polyvinylideneflouride (PVDF) mesh (Dynamesh ®-HIATUS) cruroplasty versus suture-only repair of large hiatus hernia: the DYNAMIC Study (oral presentation)
Background: Gastro-oesophageal reflux disease (GORD) is a significant health problem affecting up to 25% of adults. Keyhole surgical treatment of chronic GORD has become an alternative to medical treatment over the past 20 years. However, patients with large hiatus hernias more than 5cm in size appear to have poorer results with recurrence in up to half of the patients. The use of mesh reinforcement has been considered to improve this, as this has been efficacious in other hernia repairs. However, with hiatal hernia repair there have been concerns about risks of mesh erosion and infection, and results to date have been equ...
Source: International Journal of Surgery - November 1, 2018 Category: Surgery Authors: S. Toh, B. Knight, C. Fogg, E. Baddesley, A. Higginson, R. Beable, S. Babu, E. Hawes, M. Moon, J. Shoebridge, P. Meredith, M. Amos-Lyons, P. May-Miller Source Type: research