The role of body mass index in determining clinical and quality of life outcomes after laparoscopic anti-reflux surgery
AbstractBackgroundCurrent literature is conflicted regarding the efficacy of laparoscopic anti-reflux surgery (LARS) among obese patients complaining of pathologic reflux or otherwise symptomatic hiatal hernias. Controlling for other factors, this study examined the influence of preoperative body mass index (BMI) on clinical and subjective quality of life (QOL) outcomes following LARS.MethodsPatients who underwent LARS between February 2012 and April 2018 were subdivided into four BMI stratified categories according to CDC definitions: normal (18.5 to  
Source: Surgical Endoscopy - May 6, 2019 Category: Surgery Source Type: research

Gastroesophageal reflux and serum biomarkers in systemic sclerosis –associated interstitial lung disease: comment on the article by Elhai et al
Arthritis&Rheumatology, EarlyView. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - May 6, 2019 Category: Rheumatology Authors: Sergey Moiseev, Antonina Sosnovskaya, Fatima Chotchaeva, Elena Shchegoleva, Pavel Novikov Tags: Letters Source Type: research

Polymorphisms of the BARX1 and ADAMTS17 locus genes in individuals with gastroesophageal reflux disease.
Conclusion: : This is a study investigating the potential correlation between 2 BARX1 and ADAMTS17 polymorphisms and the development of GERD, showing a considerable association between both polymorphisms and the disease. This finding suggests that esophageal differentiation or altered regulation on microfibrils in the cell environment could be implicated as possible mechanisms in the pathogenesis of GERD. PMID: 31048564 [PubMed - as supplied by publisher] (Source: Journal of Neurogastroenterology and Motility)
Source: Journal of Neurogastroenterology and Motility - May 4, 2019 Category: Gastroenterology Tags: J Neurogastroenterol Motil Source Type: research

What Is the Best Operation for Proximal Gastric Cancer and Distal Esophageal Cancer?
This article summarizes the available evidence on this topic, and highlights specific areas for further research. PMID: 31047035 [PubMed - in process] (Source: The Surgical Clinics of North America)
Source: The Surgical Clinics of North America - May 4, 2019 Category: Surgery Authors: Mazer LM, Poultsides GA Tags: Surg Clin North Am Source Type: research

Bilateral duplex collecting system with bilateral vesicoureteral reflux: a case report
ConclusionsA bilateral duplex collecting system with refluxing upper pole moiety ureter is a very rare entity. The diagnosis should be suspected when exploring any flank pain with recurrent urinary tract infections to avoid subsequent renal impairment. Furthermore, this case shows how some common symptoms may lead to finding an unexpected urinary tract abnormality. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 4, 2019 Category: General Medicine Source Type: research

Gastroesophageal reflux and antacid therapy in IPF: analysis from the Australia IPF Registry
Gastroesophageal reflux disease (GORD) is highly prevalent in idiopathic pulmonary fibrosis (IPF) and may play a role in its pathogenesis. Recent IPF treatment guidelines suggest that all patients with IPF be ... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - May 3, 2019 Category: Respiratory Medicine Authors: Helen E. Jo, Tamera J. Corte, Ian Glaspole, Christopher Grainge, Peter M. A. Hopkins, Yuben Moodley, Paul N. Reynolds, Sally Chapman, E. Haydn Walters, Christopher Zappala, Heather Allan, Gregory J. Keir, Wendy A. Cooper, Annabelle M. Mahar, Samantha Elli Tags: Research article Source Type: research

Transoral incisionless fundoplication with EsophyX for gastroesophageal reflux disease: clinical efficacy is maintained up to 10 years
Conclusions Transoral incisionless fundoplication with EsophyX is an effective therapeutic option for symptomatic gastroesophageal reflux disease patients, with Hill grades I – II or hiatal hernia 
Source: Endoscopy International Open - May 2, 2019 Category: Gastroenterology Authors: Testoni, Pier Alberto Testoni, Sabrina Distefano, Giovanni Mazzoleni, Giorgia Fanti, Lorella Passaretti, Sandro Tags: Original article Source Type: research

Relationship between esophageal motility and severity of gastroesophageal reflux disease according to the Los Angeles classification
We examined 124 patients with GERD from January 2016 to June 2018. The LA classification of each patient was determined by endoscopy. HRM was performed by the intraluminal water infusion method. HRM and 24-hour esophageal pH monitoring parameters of the patients were studied and statistically compared. On HRM examination, GERD symptoms were found to be associated with worsened distal contractile integral (DCI), ineffective esophageal motility (IEM), peristalsis break (PB), lower esophageal sphincter (LES) pressure, and the 4-second integrated relaxation pressure (IRP4s) of LES pressure along with the grade of LA classific...
Source: Medicine - May 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Immobilization of Cu(II) on MWCNTs@L-His as a new high efficient reusable catalyst for the synthesis of pyrido[2,3-d:5,6-d′]dipyrimidine derivatives
Publication date: Available online 29 April 2019Source: Journal of Organometallic ChemistryAuthor(s): Hakimeh Saeidiroshan, Leila MoradiAbstractIn this research, a new heterogeneous organometallic catalyst was prepared through Cu(II) Immobilization on l-Histidine Functionalized multi-walled carbon nanotubes (MWCNTs@L-His/Cu(II)). Catalyst was prepared using a simple method and characterized by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), Transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), thermal analysis (TGA), inductively coupled plasma optical emission spectrometry (IC...
Source: Journal of Organometallic Chemistry - May 1, 2019 Category: Chemistry Source Type: research

Extract of Plantago asiatica L. Seeds Ameliorates Hypertension in Spontaneously Hypertensive Rats by Inhibition of Angiotensin Converting Enzyme
In this study, we investigated the antihypertensive effect and underlying mechanisms of P. asiatica L. seeds extract (PASE) in spontaneously hypertensive rat (SHR). Male SHRs were treated with 2.5 mg/kg of fosinopril (FOS) and 400 mg/kg of PASE orally per day for once or 12 weeks. SHR or Wistar-Kyoto rats (WKY) receiving vehicle (distilled water) was used as control. The results demonstrated systolic, diastolic, and mean blood pressures (SBP, DBP, and MBP) were significantly lowered after single and long-term intragastric administration of PASE. The cardiac and aortic index and collagen accumulation were improved in the PA...
Source: Frontiers in Pharmacology - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

High-Resolution Manometry Diagnosis of Ineffective Esophageal Motility Is Associated with Higher Reflux Burden
AbstractIntroductionIneffective esophageal motility (IEM) is the most commonly diagnosed abnormality on high-resolution manometry (HRM). However, the clinical significance of IEM and associated reflux burden remains unclear.AimOur primary aim was to compare reflux patterns between IEM versus normal motility on HRM.MethodsHRM and reflux studies in patients with IEM and normal motility were retrospectively reviewed. Esophageal pressure topography parameters, reflux variables, and patient-reported outcome questionnaires were explored.ResultsA total of 239 patients with IEM were explored. Of these, 146 underwent reflux monitor...
Source: Digestive Diseases and Sciences - April 30, 2019 Category: Gastroenterology Source Type: research

Anti-reflux mucosectomy with band ligation in the treatment of refractory gastroesophageal reflux disease
Endoscopy DOI: 10.1055/a-0875-3479 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - April 30, 2019 Category: Gastroenterology Authors: Monino, Laurent Gonzalez, Jean-Michel Vitton, Veronique Barthet, Marc Tags: E-Videos Source Type: research

Efficacy and safety of hangeshashinto for treatment of GERD refractory to proton pump inhibitors
AbstractBackgroundProton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (GERD) leads to a clinical decline in the quality of life (QOL). Therefore, new treatment options are needed. We performed a multicenter, randomized, parallel-group exploratory trial to determine the efficacy of hangeshashinto (HST) in patients with PPI-refractory GERD.MethodsWe enrolled 78 patients with PPI-refractory GERD for standard PPI regimens for at least 4  weeks and randomly assigned patients to receive either a combination of usual dose of rabeprazole (10 mg/day) + HST (7.5 g/day; HST group) or a ...
Source: Journal of Gastroenterology - April 29, 2019 Category: Gastroenterology Source Type: research

2007 –2019: a “Third”-Space Odyssey in the Endoscopic Management of Gastrointestinal Tract Diseases
AbstractPurpose of reviewThe main scope of this review article is to introduce readers to the innovative field of third-space endoscopy and offer a closer look at its history, milestones, and procedure spectrum while discussing ongoing and future challenges arising from its increasing adoption worldwide.Recent findingsOver the past few years, third-space endoscopy has been utilized in various diagnostic and interventional procedures performed throughout the gastrointestinal tract: obliteration of Zenker ’s diverticulum, myotomy for achalasia, gastroparesis or Hirschsprung’s disease, biopsy or removal of subepit...
Source: Current Treatment Options in Gastroenterology - April 29, 2019 Category: Gastroenterology Source Type: research

Esophageal symptoms and their lack of association with high-resolution manometry in systemic sclerosis patients
ConclusionWe observed a high prevalence of esophageal symptoms and of HRM abnormalities. However, there was no clear association between symptomatology and HRM findings. HRM does not seem to accurately predict upper GI symptomatology.ResumenAntecedentesLa afectación esofágica en la esclerosis sistémica causa impacto en la morbimortalidad. La manometría de alta resolución evalúa la afectación esofágica. Nuestro objetivo fue categorizar el trastorno motor esofágico en pacientes con esclerosis sistémica por HRM.MétodosSe realizó un estudio obs...
Source: Reumatologia Clinica - April 28, 2019 Category: Rheumatology Source Type: research

Correlation Between Clinical Signs and High-resolution Manometry Data in Children
Conclusions: With nonspecific clinical signs suggesting an esophageal motility disorder, weight loss was a predictive sign of abnormal HRM results. HRM was well tolerated in pediatric patients, and ineffective esophageal motility appears to be the most frequent motility disorder in our cohort, as already observed in adult patient studies. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Development of a Core Outcome Set for Infant Gastroesophageal Reflux Disease
Conclusions: We developed a COS for infant GERD consisting of 9 items that should minimally be measured in future therapeutic trials to decrease study heterogeneity and ease comparability of results. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - April 26, 2019 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

The Cellular Origin of Barrett's Esophagus and Its Stem Cells.
Authors: Xian W, Duleba M, Zhang Y, Yamamoto Y, Ho KY, Crum C, McKeon F Abstract The incidence of esophageal adenocarcinoma is rapidly increasing in Western countries. This is despite the introduction of sophisticated endoscopic techniques and our ability to readily monitor the presumed precursor lesion known as Barrett's esophagus. Preemptive approaches, including radiofrequency ablation (RFA), and photodynamic therapy (PDT) for Barrett's esophagus and dysplasia are achieving dramatic initial results. Although the long-term efficacy of these nonspecific ablative therapies is awaiting longitudinal studies, reports ...
Source: Advances in Experimental Medicine and Biology - April 26, 2019 Category: Research Tags: Adv Exp Med Biol Source Type: research

Effects of Proton Pump Inhibitors on the Gastrointestinal Microbiota in Gastroesophageal Reflux Disease
We examined the association between the PPI usage and the microbiota present in gastric mucosal and fecal samples from GERD patients and healthy controls (HCs) using 16S rRNA gene sequencing. GERD patients taking PPIs were further divided into short-term and long- term PPI user groups. We showed that PPI administration lowered the relative bacterial diversity of the gastric microbiota in GERD patients. Compared to the non-PPI-user and HC groups, higher abundances of Planococcaceae, Oxalobacteraceae, and Sphingomonadaceae were found in the gastric microbiota from the PPI-user group. In addition, the Methylophilus genus was ...
Source: Genomics, Proteomics and Bioinformatics - April 25, 2019 Category: Bioinformatics Source Type: research

Identification and structural characterization of the stress degradation products of omeprazole using Q-TOF-LC-ESI-MS/MS and NMR experiments: evaluation of the toxicity of the degradation products
New J. Chem., 2019, Advance Article DOI: 10.1039/C9NJ00932A, PaperG. Shankar, Roshan M. Borkar, Suresh Udutha, M. Kanakaraju, G. Sai Charan, S. Misra, R. Srinivas Omeprazole (OMP), a prototype proton pump inhibitor used for the treatment of peptic ulcers and gastroesophageal reflux disease (GERD), was subjected to forced degradation studies as per ICH guidelines Q1A (R2). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 25, 2019 Category: Chemistry Authors: G. Shankar Source Type: research

Dor versus Toupet fundoplication after Laparoscopic Heller Myotomy: Systematic review and Bayesian meta-analysis of randomized controlled trials.
Abstract Laparoscopic Heller Myotomy (LHM) with partial fundoplication has become the treatment of choice for esophageal achalasia. However, the choice of the partial fundoplication is debated. The aim of this study was to compare outcomes for Dor and Toupet fundoplication after LHM. A systematic search of randomized controlled trials comparing Dor and Toupet fundoplication was performed using PubMed, EMBASE and Web of Science. Three studies met the inclusion criteria. Overall, 174 patients were included in the analysis. The postoperative abnormal acid reflux [pooled Risk Ratio 0.98 (95% HPD 0.54-1.80)] and dyspha...
Source: Asian Journal of Surgery - April 25, 2019 Category: Surgery Authors: Aiolfi A, Tornese S, Bonitta G, Cavalli M, Rausa E, Micheletto G, Campanelli G, Bona D Tags: Asian J Surg Source Type: research

The Effect of Gastric Helicobacter pylori Colonization on Nasal Functions.
tar B, Uyar Y Abstract The aim of this study is to investigate the effect of gastric Helicobacter pylori colonization on nasal functions. The study enrolled patients (n = 100) who underwent endoscopy for gastroesophageal reflux disease. Patients with laryngopharyngeal reflux (LPR) were identified by Reflux Symptom Index (RSI) and Reflux Finding Score (RFS). Patients were divided into 2 groups: LPR (+) (n = 64) H pylori (+), RSI> 13, RFS> 7; LPR (-) (n = 36) H pylori (+), RSI
Source: Ear, Nose and Throat Journal - April 24, 2019 Category: ENT & OMF Authors: Kumral TL, Gökden Y, Saltürk Z, Berkiten G, Yıldırım G, Ataç E, Tutar B, Uyar Y Tags: Ear Nose Throat J Source Type: research

Thirty Years of Minimally Invasive Surgery in Children: Analysis of Meta-Analyses
Conclusion In the available MAs, the advantages of MIS seem to outnumber the disadvantages. However, for some types of procedures, MIS may have considerable disadvantages. More randomized controlled trials are required to confirm the advantage of MIS for most procedures. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: European Journal of Pediatric Surgery)
Source: European Journal of Pediatric Surgery - April 23, 2019 Category: Surgery Authors: Schukfeh, Nagoud Kuebler, Joachim F. Dingemann, Jens Ure, Benno M. Tags: Original Article Source Type: research

Visceral fat thickness of erosive and non-erosive reflux disease subjects in Indonesia's tertiary referral hospital
ConclusionVisceral fat thickness as measured by ultrasonography has no significant difference between NERD and ERD. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - April 21, 2019 Category: Endocrinology Source Type: research

Benefit of Laparoendoscopic Repair of Hiatal Hernia in the Presence of Aberrant Left Hepatic Artery.
Conclusion: The laparoendoscopic technique of hiatal hernia repair, using extracorporeal arthroscopic sliding knots and concomitant transoral incisionless fundoplication, is safe, preserves an ALHA, and allows proper surgical techniques in a confined operative field. PMID: 30996584 [PubMed - in process] (Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons)
Source: JSLS : Journal of the Society of Laparoendoscopic Surgeons - April 20, 2019 Category: Surgery Tags: JSLS Source Type: research

Analyzing the effect of laparoscopy duration time on peroperative gastroesophageal reflux
Conclusion: Esophageal pH values decreased and continued to remain low following IAP increase and TP in this experimental rat model. Prolonged laparoscopic procedures can particularly lead to GER that requires instant recognition and rapid and appropriate intervention. PMID: 30997979 [PubMed - as supplied by publisher] (Source: Turkish Journal of Medical Sciences)
Source: Turkish Journal of Medical Sciences - April 19, 2019 Category: General Medicine Tags: Turk J Med Sci Source Type: research

Esophageal schwannomas: A rarity beneath benign esophageal tumors a case report
ConclusionThe knowledge about a new case, impacts in obtaining more information about the clinical course and surgical treatment of this tumor. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - April 19, 2019 Category: Surgery Source Type: research

Laparoscopic Heller Myotomy: A Fundoplication Is Necessary to Control Gastroesophageal Reflux
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - April 19, 2019 Category: Surgery Authors: Marco Di Corpo Timothy M. Farrell Marco G. Patti Source Type: research

Laparoscopic Heller Myotomy: A Fundoplication Is Necessary to Control Gastroesophageal Reflux
Journal of Laparoendoscopic&Advanced Surgical Techniques, Ahead of Print. (Source: Journal of Laparoendoscopic and Advanced Surgical Techniques)
Source: Journal of Laparoendoscopic and Advanced Surgical Techniques - April 19, 2019 Category: Surgery Authors: Marco Di Corpo Timothy M. Farrell Marco G. Patti Source Type: research

Gastroesophageal reflux and serum biomarkers in systemic sclerosis ‐related interstitial lung disease. Reply
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 17, 2019 Category: Rheumatology Authors: Muriel Elhai, Anna Maria Hoffmann ‐Vold, Yannick Allanore Tags: Reply to Letter to the Editor Source Type: research

Revision of Sleeve Gastrectomy with Hiatal Repair with Gastropexy for Gastroesophageal Reflux Disease
ConclusionHiatal repair with gastropexy is an acceptable treatment option for GERD after LSG but not very effective because of partial remission of symptoms. (Source: Obesity Surgery)
Source: Obesity Surgery - April 17, 2019 Category: Surgery Source Type: research

Characteristics and Findings of Childhood Urinary Tract Infection in the Last Decade
Conclusions: First UTI in a group of Thai children occurred in approximately equal proportion in boys and girls but boys were younger at diagnosis. Kidney and urinary tract anomalies were detected in half of the children.Urol Int (Source: Urologia Internationalis)
Source: Urologia Internationalis - April 16, 2019 Category: Urology & Nephrology Source Type: research

Juvenile-onset mixed connective tissue disease associated with macrophage activation syndrome: A case with refractory Raynaud’s phenomenon
ConclusionMCTD may present with a myriad of rheumatic manifestations and in association with MAS the diagnosis and management may be challenging. Refractory Raynauds’ phenomenon may remarkably improve on transthoracic sympathectomy. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - April 16, 2019 Category: Rheumatology Source Type: research

Addition of the Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m to Prolonged and Moderate Exercise Training Enhanced Protection of the Rat Heart From Type-1 Diabetes
Bartolo Ferraro1,2, Maria Donniacuo3, Loredana Sodano3, Franca Ferraraccio4, Rosa Maisto3, Eliana Gulotta5, Gorizio Pieretti6, Michele D’Amico3*, Maria Consiglia Trotta3 and Barbara Rinaldi3 1Institute for Cardiovascular Prevention (IPEK), Ludwig Maximilian University of Munich, Munich, Germany 2DZHK, Partner Site Munich Heart Alliance, Munich, Germany 3Department of Experimental Medicine, Pharmacology Division, University of Campania “L. Vanvitelli”, Naples, Italy 4Department of Clinical, Public and Preventive Medicine, University of Campania “L. Vanvitelli”, Naples, Italy 5Departm...
Source: Frontiers in Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Sleep Is Compromised in −12° Head Down Tilt Position
Sleep Is Compromised in −12° Head Down Tilt Position Alessa L. Boschert1*, David Elmenhorst2,3, Peter Gauger1, Zhili Li4, Maria T. Garcia-Gutierrez5, Darius Gerlach1, Bernd Johannes1, Jochen Zange1, Andreas Bauer2,6 and Jörn Rittweger1,7 1Department of Muscle and Bone Metabolism, German Aerospace Center (DLR), Institute of Aerospace Medicine, Cologne, Germany 2Forschungszentrum Jülich, Institute of Neuroscience and Medicine (INM-2), Jülich, Germany 3Division of Medical Psychology, University of Bonn, Bonn, Germany 4State Key Laboratory of Space Medicine Fundamentals and Application, China ...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release
Alyce M. Martin1, Emily W. Sun1, Geraint B. Rogers2,3 and Damien J. Keating1,4* 1Molecular and Cellular Physiology Laboratory, College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia 2Microbiome Research Laboratory, Flinders University, Adelaide, SA, Australia 3Infection and Immunity, South Australian Health and Medical Research Institute, Adelaide, SA, Australia 4Nutrition and Metabolism, South Australian Health and Medical Research Institute, Adelaide, SA, Australia The microbial community of the gut conveys significant benefits to host physiology. A clear relationship has now bee...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research

History of gastroesophageal reflux disease in patients with suspected coronary artery disease
AbstractIt is well known that patients with gastroesophageal reflux disease (GERD) experience GERD-related chest pain, but little is known about the relationship between GERD and coronary artery disease (CAD). We evaluated medical history of GERD in patients with suspected CAD and its association with types of CAD. We enrolled 236 patients who underwent coronary angiography (CAG). We assessed past medical history of each patient, making note of esophageal or stomach diseases such as GERD including reflux esophagitis and non-erosive reflux disease. The patients were divided into the following three subgroups based on the CA...
Source: Heart and Vessels - April 16, 2019 Category: Cardiology Source Type: research

Higher clinical suspicion is needed for prompt diagnosis of esophageal adenocarcinoma in young patients
Esophageal cancer is considered a disease of the elderly. Although the incidence of esophageal adenocarcinoma in young patients is increasing, guidelines for endoscopic evaluation of gastroesophageal reflux disease and Barrett ’s esophagus include age as a cutoff. There is a paucity of data on the presentation and treatment of esophageal cancer in young patients. Most studies are limited by small sample sizes and conflicting findings are reported regarding delayed diagnosis and survival compared to older patients. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 16, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Tamar Nobel, Michael Curry, Renee Gennarelli, David Jones, Daniela Molena Source Type: research

Chronic cough and gastroesophageal reflux in children - CHEST Guideline and Expert Panel Report.
CONCLUSION: The panelists endorsed that: (1) treatment(s) for GERD should not be used when there are no clinical features of GERD and; (2) pediatric GERD guidelines should be used to guide treatment and investigations. PMID: 31002783 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 16, 2019 Category: Respiratory Medicine Authors: Chang AB, Oppenheimer JJ, Kahrilas PJ, Kantar A, Rubin BK, Weinberger M, Irwin RS, CHEST Expert Cough Panel Tags: Chest Source Type: research

The Rationale and Efficacy of Primary and Secondary Prevention in Adenocarcinomas of the Upper Gastrointestinal Tract
While the primary risk factor for oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett ’s oesophagus (BO) is gastro-oesophageal reflux, the infection withHelicobacter pylori (H. pylori) is the dominant risk factor for gastric cancer. Reduction of reflux by dietary measures and proton pump inhibitors has some merits in OAC prevention, and the chemopreventive effect of Aspirin and statins is being widely investigated; however, improved outcome in OAC occurs primarily as the result of secondary prevention. Early detection of neoplastic lesions in Barrett ’s metaplasia can be achieved by surveillance e...
Source: Digestive Diseases - April 15, 2019 Category: Gastroenterology Source Type: research

High-fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett ’s Esophagus via IL8 and Alterations to the Gut Microbiome
Barrett ’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased abdominal pressure and gastroesophageal reflux disease, although this pathogenic mechanism has not been proven. We investigated whether environme ntal or dietary factors associated with obesity contribute to progression of BE to EAC in mice. (Source: Gastroenterology)
Source: Gastroenterology - April 15, 2019 Category: Gastroenterology Authors: Natasha Stephens M ünch, Hsin-Yu Fang, Jonas Ingermann, H. Carlo Maurer, Akanksha Anand, Victoria Kellner, Vincenz Sahm, Maria Wiethaler, Theresa Baumeister, Frederik Wein, Henrik Einwächter, Florian Bolze, Martin Klingenspor, Dirk Haller, Maria Kavanag Source Type: research

High-Fat Diet Accelerates Carcinogenesis in a Mouse Model of Barrett ’s Esophagus via Interleukin 8 and Alterations to the Gut Microbiome
Barrett ’s esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased abdominal pressure and gastroesophageal reflux disease, although this pathogenic mechanism has not been proven. We investigated whether environme ntal or dietary factors associated with obesity contribute to the progression of BE to EAC in mice. (Source: Gastroenterology)
Source: Gastroenterology - April 15, 2019 Category: Gastroenterology Authors: Natasha Stephens M ünch, Hsin-Yu Fang, Jonas Ingermann, H. Carlo Maurer, Akanksha Anand, Victoria Kellner, Vincenz Sahm, Maria Wiethaler, Theresa Baumeister, Frederik Wein, Henrik Einwächter, Florian Bolze, Martin Klingenspor, Dirk Haller, Maria Kavanag Tags: Basic and Translational —Alimentary Tract Source Type: research

Tracer-free liquid – vapor imaging using lifetime-filtered planar laser-induced fluorescence
The separation of liquid phase and vapor phase laser-induced fluorescence (LIF) signals using tracer species suffers from uncertainties in tracer – fuel coevaporation, as well as a disparity in liquid and vapor signals. This work demonstrates the use of a simple technique, referred to as ... (Source: Optics Letters)
Source: Optics Letters - April 14, 2019 Category: Physics Authors: Alber Douglawi Anthony McMaster Megan E. Paciaroni James B. Michael Benjamin R. Halls James R. Gord Terrence R. Meyer Source Type: research

Foregut Function Before and After Lung Transplant
Esophageal dysmotility and gastroesophageal reflux disease (GERD) are common in patients with advanced lung disease, and can potentially affect outcomes of lung transplant (LTx); however, the effects of LTx on foregut function remain unknown. We assessed foregut function before and after bilateral LTx. (Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - April 13, 2019 Category: Cardiovascular & Thoracic Surgery Authors: Takahiro Masuda, Sumeet K. Mittal, Bal ázs Kovács, Michael A. Smith, Rajat Walia, Jasmine L. Huang, Ross M. Bremner Source Type: research

A novel endoloop pretest to treat severe gastroesophageal reflux disease symptoms before anti-reflux mucosectomy
Endoscopy DOI: 10.1055/a-0861-9849 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Endoscopy)
Source: Endoscopy - April 12, 2019 Category: Gastroenterology Authors: Min, Min Liu, Yan Tags: E-Videos Source Type: research

Preliminary optimization of acupuncture regimen at Nèiguān (PC 6) for gastroesophageal reflux disease
ConclusionIn the observation of five factors and two levels, the optimal regimen of acupuncture for GERD includes reducing technique by rotating needle at PC 6, the time of rotating needle for 60 s, Zúsānlĭ (足三里 ST 36) and Tàichōng (太冲 LR 3) as the supplementary acupoints, needle retention for 30 min and treatment interval of 24 h. (Source: World Journal of Acupuncture Moxibustion)
Source: World Journal of Acupuncture Moxibustion - April 11, 2019 Category: Complementary Medicine Source Type: research

Evaluation of Baseline Impedance During Water-perfused High Resolution Impedance Manometry in Patients With Symptomatic GERD
Goals: We aimed to investigate the hypothesis whether baseline impedance measured during water-perfused high resolution impedance manometry (HRIM) can help discriminate patients with reflux symptoms from the controls and predict the response to the proton pump inhibitors (PPIs). Background/Aim: Baseline impedance measured during solid-state HRIM can reliably discriminate patients with gastroesophageal reflux disease (GERD) from controls. Study: We enrolled consecutive patients with typical reflux symptoms and healthy controls for the measurement of baseline impedance during the landmark period of HRIM. All patients...
Source: Journal of Clinical Gastroenterology - April 10, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Evaluation of Important Analytical Parameters of the Peptest Immunoassay that Limit its Use in Diagnosing Gastroesophageal Reflux Disease
Conclusions: The Peptest assay’s sensitivity and specificity is low, the results are highly variable and it should not be used as a near-patient diagnostic method in primary care. (Source: Journal of Clinical Gastroenterology)
Source: Journal of Clinical Gastroenterology - April 10, 2019 Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research

Functional Gastrointestinal Disease in Autism Spectrum Disorder: A Retrospective Descriptive Study in a Clinical Sample
Conclusions: Almost one-third of ASD patients in our sample had at least one fGID. The presence of fGID was associated with ID, sleep problems and with behavioral problems (as measured by the prescription of psychotropic drugs). This subsample of ASD patients with fGID deserves particular attention in future research projects, focusing on specific phenotypic characteristics and overlapping biological markers that may underlie both pathologies. Introduction Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by impairments in social communication and restricted, repetitive patterns ...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Outcomes of One Anastomosis Gastric Bypass in the IFSO Middle East North Africa (MENA) Region
AbstractIntroductionSince it was first described in 2001, the one anastomosis gastric bypass (OAGB) has been gaining popularity in the Middle East region and worldwide. We designed a survey to evaluate the trends, techniques, and outcomes of OAGB in our region.MethodsA questionnaire to study OAGB was sent to the members of the IFSO MENA chapter.ResultsOne-hundred and forty-eight surgeons (74%) responded. Forty-six percent of all respondents (64 surgeons) performed OAGB routinely. The most commonly performed procedures were the laparoscopic sleeve gastrostomy (LSG), followed by OAGB, and then Roux-en-Y (RYGB). Of the surgeo...
Source: Obesity Surgery - April 10, 2019 Category: Surgery Source Type: research