GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1 ‑autophagy axis
In conclusion, GDF11 may exert tumor-suppressive properties in HCC cells through inactivating the mTORC1 signaling pathway to strengthen autophagy.PMID:38682112 | PMC:PMC11046183 | DOI:10.3892/etm.2024.12540 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Qingyi Wu Chan Fan Kebo Liu Jiefu Tang Source Type: research
Alkaloids from < em > Zanthoxylum nitidum < /em > and their anti-proliferative activity against A549 cells by regulating the EGFR/AKT/mTOR pathway
Nat Prod Res. 2024 Apr 29:1-7. doi: 10.1080/14786419.2024.2347463. Online ahead of print.ABSTRACTZanthoxylum nitidum is frequently used as a traditional Chinese medicine and food supplement. Our previous study revealed that its constituent compounds were able to inhibit cancer cell proliferation. In our continuous exploration of bioactive compounds in Z. nitidum, we isolated ten alkaloids (1-10), including one new natural compound (1), and nine known alkaloids (2-10), from an ethanolic extract of the whole plant. The chemical structures were elucidated based on a combination of comprehensive NMR and HRESIMS analyses. Compo...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Fan-Fan Wang Ping-Fang Tao Yu-Jun Zhong Yun-Qiong Gu Cai Yi Wang Feng Qin Source Type: research
Tumour-derived exosome SNHG17 induced by oestrogen contributes to ovarian cancer progression via the CCL13-CCR2-M2 macrophage axis
In this study, we found that SNHG17 expression was significantly increased in ovarian cancer and positively correlated with oestrogen treatment. Oestrogen could promote M2 macrophage polarization as well as ovarian cancer cells SKOV3 and ES2 cell exosomal SNHG17 expression. When exposure to oestrogen, exosomal SNHG17 promoted ovarian cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro, and tumour growth and lung metastasis in vivo by accelerating M2-like phenotype of macrophages. Mechanically, exosomal SNHG17 could facilitate the release of CCL13 from M2 macrophage via the PI...
Source: J Cell Mol Med - April 29, 2024 Category: Molecular Biology Authors: Haiyan Liang Shuo Geng Yadong Wang Qing Fang Yongfeng Xin Yanqing Li Source Type: research
Epithelial-mesenchymal transition in tissue repair and degeneration
Nat Rev Mol Cell Biol. 2024 Apr 29. doi: 10.1038/s41580-024-00733-z. Online ahead of print.ABSTRACTEpithelial-mesenchymal transitions (EMTs) are the epitome of cell plasticity in embryonic development and cancer; during EMT, epithelial cells undergo dramatic phenotypic changes and become able to migrate to form different tissues or give rise to metastases, respectively. The importance of EMTs in other contexts, such as tissue repair and fibrosis in the adult, has become increasingly recognized and studied. In this Review, we discuss the function of EMT in the adult after tissue damage and compare features of embryonic and ...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Khalil Kass Youssef M Angela Nieto Source Type: research
Tumour-derived exosome SNHG17 induced by oestrogen contributes to ovarian cancer progression via the CCL13-CCR2-M2 macrophage axis
In this study, we found that SNHG17 expression was significantly increased in ovarian cancer and positively correlated with oestrogen treatment. Oestrogen could promote M2 macrophage polarization as well as ovarian cancer cells SKOV3 and ES2 cell exosomal SNHG17 expression. When exposure to oestrogen, exosomal SNHG17 promoted ovarian cancer cell proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in vitro, and tumour growth and lung metastasis in vivo by accelerating M2-like phenotype of macrophages. Mechanically, exosomal SNHG17 could facilitate the release of CCL13 from M2 macrophage via the PI...
Source: Molecular Medicine - April 29, 2024 Category: Molecular Biology Authors: Haiyan Liang Shuo Geng Yadong Wang Qing Fang Yongfeng Xin Yanqing Li Source Type: research
Immune cell senescence and exhaustion promote the occurrence of liver metastasis in colorectal cancer by regulating epithelial-mesenchymal transformation
CONCLUSION: This study elucidates the potential molecular mechanisms underlying the occurrence of LM from various angles through single-cell multi-omics analysis in CRC. It also constructs a network illustrating the role of senescent or exhausted immune cells in regulating EMT.PMID:38683136 | DOI:10.18632/aging.205778 (Source: Aging)
Source: Aging - April 29, 2024 Category: Biomedical Science Authors: Sen Lin Lanyue Ma Jiaxin Mo Ruiqi Zhao Jinghao Li Mengjiao Yu Mei Jiang Lisheng Peng Source Type: research
Exploring new frontiers: cell surface vimentin as an emerging marker for circulating tumor cells and a promising therapeutic target in advanced gastric Cancer
CONCLUSION: In summary, leveraging CSV as a universal CTCs marker represents a significant breakthrough in advancing personalized medicine for patients with advanced GC. This research not only paves the way for tailored therapeutic strategies but also underscores the pivotal role of CSV in enhancing GC management, opening new frontiers for precision medicine.PMID:38685125 | DOI:10.1186/s13046-024-03043-6 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Heming Li Yang-Zhuangzhuang Zhu Lu Xu Tao Han Jiasi Luan Xin Li Yuting Liu Zhi Wang Qiuge Liu Xiangyu Kong Chunpu Zou Lin Su Yifei Hou Xiao Chen Lujun Chen Ruoyu Wang Zihang Xu Mingfang Zhao Source Type: research
Exploring new frontiers: cell surface vimentin as an emerging marker for circulating tumor cells and a promising therapeutic target in advanced gastric Cancer
CONCLUSION: In summary, leveraging CSV as a universal CTCs marker represents a significant breakthrough in advancing personalized medicine for patients with advanced GC. This research not only paves the way for tailored therapeutic strategies but also underscores the pivotal role of CSV in enhancing GC management, opening new frontiers for precision medicine.PMID:38685125 | DOI:10.1186/s13046-024-03043-6 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Heming Li Yang-Zhuangzhuang Zhu Lu Xu Tao Han Jiasi Luan Xin Li Yuting Liu Zhi Wang Qiuge Liu Xiangyu Kong Chunpu Zou Lin Su Yifei Hou Xiao Chen Lujun Chen Ruoyu Wang Zihang Xu Mingfang Zhao Source Type: research
In Vitro Antiviral and Anticancer Effects of Tanacetum sinaicum Essential Oil on Human Cervical and Breast Cancer
CONCLUSION: Tanacetum sinaicum EO is a prospective source of natural bioactive compounds that can be employed in pharmaceutical and medicinal applications due to its antiviral, antiproliferative, anti-metastatic and genotoxic properties.PMID:38680008 | DOI:10.31557/APJCP.2024.25.4.1457 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Abeer A Sheashea Fatma A Ahmed Emad El Zayat Bassam W Ebeed Mostafa H Elberry Zeinab K M Hassan Mohamed M Hafez Source Type: research
Expression of CLLD7 and CHC1L Proteins in Oral Epithelial Dysplasia in a Group of Thai Patients
CONCLUSION: The subcellular mislocalization of CLLD7 and CHC1L in OED suggests that the expression of these potential tumor suppressor proteins might be dysregulated during the dysplastic process. The distinct membrane staining of CHC1L observed in OED but not in NOM is a useful characteristic that can be used to separate OED from NOM. Thus, CHC1L may be a good marker to assist in the diagnosis of OED.PMID:38679985 | DOI:10.31557/APJCP.2024.25.4.1257 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Patcharanun Wiphakphongpakorn Rachai Juengsomjit Sopee Poomsawat Ounruean Meesakul Bishwa Prakash Bhattarai Boworn Klongnoi Waranun Buajeeb Siribang-On Piboonniyom Khovidhunkit Source Type: research
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1 ‑autophagy axis
In conclusion, GDF11 may exert tumor-suppressive properties in HCC cells through inactivating the mTORC1 signaling pathway to strengthen autophagy.PMID:38682112 | PMC:PMC11046183 | DOI:10.3892/etm.2024.12540 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Qingyi Wu Chan Fan Kebo Liu Jiefu Tang Source Type: research
Alkaloids from < em > Zanthoxylum nitidum < /em > and their anti-proliferative activity against A549 cells by regulating the EGFR/AKT/mTOR pathway
Nat Prod Res. 2024 Apr 29:1-7. doi: 10.1080/14786419.2024.2347463. Online ahead of print.ABSTRACTZanthoxylum nitidum is frequently used as a traditional Chinese medicine and food supplement. Our previous study revealed that its constituent compounds were able to inhibit cancer cell proliferation. In our continuous exploration of bioactive compounds in Z. nitidum, we isolated ten alkaloids (1-10), including one new natural compound (1), and nine known alkaloids (2-10), from an ethanolic extract of the whole plant. The chemical structures were elucidated based on a combination of comprehensive NMR and HRESIMS analyses. Compo...
Source: Natural Product Research - April 29, 2024 Category: Biochemistry Authors: Fan-Fan Wang Ping-Fang Tao Yu-Jun Zhong Yun-Qiong Gu Cai Yi Wang Feng Qin Source Type: research
Epithelial-mesenchymal transition in tissue repair and degeneration
Nat Rev Mol Cell Biol. 2024 Apr 29. doi: 10.1038/s41580-024-00733-z. Online ahead of print.ABSTRACTEpithelial-mesenchymal transitions (EMTs) are the epitome of cell plasticity in embryonic development and cancer; during EMT, epithelial cells undergo dramatic phenotypic changes and become able to migrate to form different tissues or give rise to metastases, respectively. The importance of EMTs in other contexts, such as tissue repair and fibrosis in the adult, has become increasingly recognized and studied. In this Review, we discuss the function of EMT in the adult after tissue damage and compare features of embryonic and ...
Source: Mol Biol Cell - April 29, 2024 Category: Molecular Biology Authors: Khalil Kass Youssef M Angela Nieto Source Type: research
In Vitro Antiviral and Anticancer Effects of Tanacetum sinaicum Essential Oil on Human Cervical and Breast Cancer
CONCLUSION: Tanacetum sinaicum EO is a prospective source of natural bioactive compounds that can be employed in pharmaceutical and medicinal applications due to its antiviral, antiproliferative, anti-metastatic and genotoxic properties.PMID:38680008 | DOI:10.31557/APJCP.2024.25.4.1457 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Abeer A Sheashea Fatma A Ahmed Emad El Zayat Bassam W Ebeed Mostafa H Elberry Zeinab K M Hassan Mohamed M Hafez Source Type: research
