Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Sesamolin serves as an MYH14 inhibitor to sensitize endometrial cancer to chemotherapy and endocrine therapy via suppressing MYH9/GSK3 β/β-catenin signaling
CONCLUSIONS: Herein, we identified that EC prognosis-associated MYH14 was independently responsible for poor overall survival time of patients, and it augmented EC progression by activating Wnt/β-catenin signaling. Targeting MYH14 by sesamolin, a cytotoxicity-based approach, can be applied synergistically with chemotherapy and endocrine therapy to eventually mitigate EC development. This study emphasizes MYH14 as a potential target and sesamolin as a valuable natural drug for EC therapy.PMID:38698330 | DOI:10.1186/s11658-024-00583-9 (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 2, 2024 Category: Molecular Biology Authors: Yibin Lin Xiao Chen Linping Lin Benhua Xu Xiaofeng Zhu Xian Lin Source Type: research
Verteporfin inhibits TGF- β signaling by disrupting the Smad2/3-Smad4 interaction
In this study, we focus on the Smad2/3-Smad4 complex, a key component in TGF-β signaling transduction, as a potential target for cancer therapy. Through a phase-separated condensate-aided biomolecular interaction system, we identified verteporfin (VP) as a small-molecule inhibitor that specifically targets the Smad2/3-Smad4 interaction. VP effectively disrupted the interaction between Smad2/3 and Smad4 and thereby inhibited canonical TGF-β signaling, but not the interaction between Smad1 and Smad4 in BMP signaling. Furthermore, VP exhibited inhibitory effects on TGF-β-induced epithelial-mesenchymal transition and cell m...
Source: Mol Biol Cell - May 2, 2024 Category: Molecular Biology Authors: Junxiu Nong Shengqiang Shen Fan Hong Fan Xiao Lingtian Meng Pilong Li Xiaoguang Lei Ye-Guang Chen Source Type: research
Sesamolin serves as an MYH14 inhibitor to sensitize endometrial cancer to chemotherapy and endocrine therapy via suppressing MYH9/GSK3 β/β-catenin signaling
CONCLUSIONS: Herein, we identified that EC prognosis-associated MYH14 was independently responsible for poor overall survival time of patients, and it augmented EC progression by activating Wnt/β-catenin signaling. Targeting MYH14 by sesamolin, a cytotoxicity-based approach, can be applied synergistically with chemotherapy and endocrine therapy to eventually mitigate EC development. This study emphasizes MYH14 as a potential target and sesamolin as a valuable natural drug for EC therapy.PMID:38698330 | DOI:10.1186/s11658-024-00583-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 2, 2024 Category: Biochemistry Authors: Yibin Lin Xiao Chen Linping Lin Benhua Xu Xiaofeng Zhu Xian Lin Source Type: research
A comprehensive review of miR-21 in liver disease: Big impact of little things
Int Immunopharmacol. 2024 May 1;134:112116. doi: 10.1016/j.intimp.2024.112116. Online ahead of print.ABSTRACTmicroRNAs (miRNAs), a class of non-coding RNA with 20-24 nucleotides, are defined as the powerful regulators for gene expression. miR-21 is a multifunctional miRNA enriched in the circulatory system and multiple organs, which not only serves as a non-invasive biomarker in disease diagnosis, but also participates in many cellular activities. In various chronic liver diseases, the increase of miR-21 affects glycolipid metabolism, viral infection, inflammatory and immune cell activation, hepatic stellate cells activati...
Source: International Immunopharmacology - May 2, 2024 Category: Allergy & Immunology Authors: Xinyan Xue Yanzhi Li Yuxin Yao Shenglin Zhang Cheng Peng Yunxia Li Source Type: research
Poorly differentiated thyroid carcinoma arising from substernal goiter: a case report
CONCLUSION: In this manuscript, the authors aimed to present a unique case report with challenging diagnostic features including the rapid development of an infiltrative poorly differentiated thyroid carcinoma from a SG highlighting the importance of a detailed histopathological examination of thyroid nodules in the absence of significant medical history.PMID:38694372 | PMC:PMC11060243 | DOI:10.1097/MS9.0000000000001868 (Source: Annals of Medicine)
Source: Annals of Medicine - May 2, 2024 Category: Internal Medicine Authors: Shant Apelian Sawsan Ismail Dommar Roumieh Bassam Saad Zuheir Alshehabi Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Sesamolin serves as an MYH14 inhibitor to sensitize endometrial cancer to chemotherapy and endocrine therapy via suppressing MYH9/GSK3 β/β-catenin signaling
CONCLUSIONS: Herein, we identified that EC prognosis-associated MYH14 was independently responsible for poor overall survival time of patients, and it augmented EC progression by activating Wnt/β-catenin signaling. Targeting MYH14 by sesamolin, a cytotoxicity-based approach, can be applied synergistically with chemotherapy and endocrine therapy to eventually mitigate EC development. This study emphasizes MYH14 as a potential target and sesamolin as a valuable natural drug for EC therapy.PMID:38698330 | DOI:10.1186/s11658-024-00583-9 (Source: Mol Biol Cell)
Source: Mol Biol Cell - May 2, 2024 Category: Molecular Biology Authors: Yibin Lin Xiao Chen Linping Lin Benhua Xu Xiaofeng Zhu Xian Lin Source Type: research
Verteporfin inhibits TGF- β signaling by disrupting the Smad2/3-Smad4 interaction
In this study, we focus on the Smad2/3-Smad4 complex, a key component in TGF-β signaling transduction, as a potential target for cancer therapy. Through a phase-separated condensate-aided biomolecular interaction system, we identified verteporfin (VP) as a small-molecule inhibitor that specifically targets the Smad2/3-Smad4 interaction. VP effectively disrupted the interaction between Smad2/3 and Smad4 and thereby inhibited canonical TGF-β signaling, but not the interaction between Smad1 and Smad4 in BMP signaling. Furthermore, VP exhibited inhibitory effects on TGF-β-induced epithelial-mesenchymal transition and cell m...
Source: Mol Biol Cell - May 2, 2024 Category: Molecular Biology Authors: Junxiu Nong Shengqiang Shen Fan Hong Fan Xiao Lingtian Meng Pilong Li Xiaoguang Lei Ye-Guang Chen Source Type: research
Sesamolin serves as an MYH14 inhibitor to sensitize endometrial cancer to chemotherapy and endocrine therapy via suppressing MYH9/GSK3 β/β-catenin signaling
CONCLUSIONS: Herein, we identified that EC prognosis-associated MYH14 was independently responsible for poor overall survival time of patients, and it augmented EC progression by activating Wnt/β-catenin signaling. Targeting MYH14 by sesamolin, a cytotoxicity-based approach, can be applied synergistically with chemotherapy and endocrine therapy to eventually mitigate EC development. This study emphasizes MYH14 as a potential target and sesamolin as a valuable natural drug for EC therapy.PMID:38698330 | DOI:10.1186/s11658-024-00583-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 2, 2024 Category: Biochemistry Authors: Yibin Lin Xiao Chen Linping Lin Benhua Xu Xiaofeng Zhu Xian Lin Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica et Cytochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors
Acta Histochem Cytochem. 2024 Apr 25;57(2):57-66. doi: 10.1267/ahc.24-00010. Epub 2024 Apr 4.ABSTRACTProtein lactylation is a post-translational modification associated with glycolysis. Although recent evidence indicates that protein lactylation is involved in epigenetic gene regulation, its pathophysiological significance remains unclear, particularly in neoplasms. Herein, we investigated the potential involvement of protein lactylation in the molecular mechanisms underlying benign and malignant pancreatic epithelial tumors, as well as its role in the response of pancreatic cancer (PC) cells to gemcitabine. Increased lact...
Source: Acta Histochemica - May 2, 2024 Category: Biochemistry Authors: Tomoki Takata Akihiro Nakamura Hiroaki Yasuda Hayato Miyake Yoshio Sogame Yuki Sawai Michiyo Hayakawa Kentaro Mochizuki Ryuta Nakao Takehiro Ogata Hisashi Ikoma Eiichi Konishi Yoshinori Harada Eigo Otsuji Yoshito Itoh Hideo Tanaka Source Type: research
Sesamolin serves as an MYH14 inhibitor to sensitize endometrial cancer to chemotherapy and endocrine therapy via suppressing MYH9/GSK3 β/β-catenin signaling
CONCLUSIONS: Herein, we identified that EC prognosis-associated MYH14 was independently responsible for poor overall survival time of patients, and it augmented EC progression by activating Wnt/β-catenin signaling. Targeting MYH14 by sesamolin, a cytotoxicity-based approach, can be applied synergistically with chemotherapy and endocrine therapy to eventually mitigate EC development. This study emphasizes MYH14 as a potential target and sesamolin as a valuable natural drug for EC therapy.PMID:38698330 | PMC:PMC11067147 | DOI:10.1186/s11658-024-00583-9 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - May 2, 2024 Category: Biochemistry Authors: Yibin Lin Xiao Chen Linping Lin Benhua Xu Xiaofeng Zhu Xian Lin Source Type: research
A perspective on tumor radiation resistance following high-LET radiation treatment
This article will discuss various types of complex clustered DNA damage, their repair mechanisms, mutagenic potential, and the development of radiation resistance strategies. Furthermore, it highlights the importance of careful consideration and patient selection when employing high-LET radiotherapy in clinical settings. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - May 2, 2024 Category: Cancer & Oncology Source Type: research
