AXL receptor as an emerging molecular target in colorectal cancer
Drug Discov Today. 2024 Apr 27:104005. doi: 10.1016/j.drudis.2024.104005. Online ahead of print.ABSTRACTAXL receptor tyrosine kinase (AXL) is a receptor tyrosine kinase whose aberrant expression has recently been associated with colorectal cancer (CRC), contributing to tumor growth, epithelial-mesenchymal transition (EMT), increased invasiveness, metastatic spreading, and the development of drug resistance. In this review we summarize preclinical data, the majority of which are limited to recent years, convincingly linking the AXL receptor to CRC. These findings support the value of targeting AXL with molecules in drug dis...
Source: Drug Discovery Today - April 30, 2024 Category: Drugs & Pharmacology Authors: Lucia De Rosa Rossella Di Stasi Virginia Fusco Luca D D'Andrea Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
Circ_0003855 involvement of esophageal cancer progression through miR-622/FLOT1
Oncol Res. 2024 Apr 23;32(5):925-931. doi: 10.32604/or.2023.042447. eCollection 2024.ABSTRACTTo confirm the relationship between Circ_0003855 and EC, we purchased the Human esophageal carcinoma cell line Eca109 and normal human esophageal epithelial cells HEEC, and the expression levels of Circ_0003855, miR-622, and FLOT1 were detected. The results show that Circ_0003855 and FLOT1 were highly expressed in Eca109 cells, while miR-622 was lowly expressed (p < 0.05). Subsequently, Circ_0003855 small interfering RNA (si-Circ_0003855) and its negative control (si-NC) were used to detect changes in cellular biological behavio...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Jingjing Tian Xibao Hu Xinrong Zhang Source Type: research
The Epstein-Barr virus-miRNA-BART6-5p regulates TGF- β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells
CONCLUSION: In this study, we found that EBV-miRNA-BART6-5p can target SMAD4, effectively increasing glycolysis in gastric cancer cells by regulating the TGF-β/SMAD4 signaling pathway, thereby enhancing the proliferation and metastasis of gastric cancer cells. Our findings may offer new insights into the metabolic aspects of gastric cancer.PMID:38686046 | PMC:PMC11055990 | DOI:10.32604/or.2024.046679 (Source: Oncology Research)
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Xuhui Zhao Xiaomin Huang Chunyan Dang Xia Wang Yujiao Qi Hongling Li Source Type: research
Circ_0003855 involvement of esophageal cancer progression through miR-622/FLOT1
Oncol Res. 2024 Apr 23;32(5):925-931. doi: 10.32604/or.2023.042447. eCollection 2024.ABSTRACTTo confirm the relationship between Circ_0003855 and EC, we purchased the Human esophageal carcinoma cell line Eca109 and normal human esophageal epithelial cells HEEC, and the expression levels of Circ_0003855, miR-622, and FLOT1 were detected. The results show that Circ_0003855 and FLOT1 were highly expressed in Eca109 cells, while miR-622 was lowly expressed (p < 0.05). Subsequently, Circ_0003855 small interfering RNA (si-Circ_0003855) and its negative control (si-NC) were used to detect changes in cellular biological behavio...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Jingjing Tian Xibao Hu Xinrong Zhang Source Type: research
The Epstein-Barr virus-miRNA-BART6-5p regulates TGF- β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells
CONCLUSION: In this study, we found that EBV-miRNA-BART6-5p can target SMAD4, effectively increasing glycolysis in gastric cancer cells by regulating the TGF-β/SMAD4 signaling pathway, thereby enhancing the proliferation and metastasis of gastric cancer cells. Our findings may offer new insights into the metabolic aspects of gastric cancer.PMID:38686046 | PMC:PMC11055990 | DOI:10.32604/or.2024.046679 (Source: Oncology Research)
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Xuhui Zhao Xiaomin Huang Chunyan Dang Xia Wang Yujiao Qi Hongling Li Source Type: research
Exploring new frontiers: cell surface vimentin as an emerging marker for circulating tumor cells and a promising therapeutic target in advanced gastric Cancer
Circulating tumor cells (CTCs) hold immense promise in guiding treatment strategies for advanced gastric cancer (GC). However, their clinical impact has been limited due to challenges in identifying epithelial... (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - April 30, 2024 Category: Cancer & Oncology Authors: Heming Li, Yang-Zhuangzhuang Zhu, Lu Xu, Tao Han, Jiasi Luan, Xin Li, Yuting Liu, Zhi Wang, Qiuge Liu, Xiangyu Kong, Chunpu Zou, Lin Su, Yifei Hou, Xiao Chen, Lujun Chen, Ruoyu Wang & hellip; Tags: Research Source Type: research
Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer
ConclusionsKCNK1 was significantly overexpressed in BC. A complex and sophisticated three-dimensional spatial transcriptional regulatory network existed in the KCNK1 TSS and promoted the upregulated of KCNK1 expression. The high expression of KCNK1 might be involved in the cell cycle, cellular metabolism, and tumour microenvironment through the regulation of potassium channels, and ultimately contributed to the deterioration of BC. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 30, 2024 Category: Research Source Type: research
Retraction Note: MicroRNA-93-5p promotes epithelial-mesenchymal transition in gastric cancer by repressing tumor suppressor AHNAK expression
(Source: Cancer Cell International)
Source: Cancer Cell International - April 30, 2024 Category: Cancer & Oncology Authors: Erdong Shen, Xin Wang, Xin Liu, Mingyue Lv, Liang Zhang, Guolian Zhu and Zhe Sun Tags: Retraction Note Source Type: research
The Expression Analysis of < em > MEST1 < /em > and < em > GJA1 < /em > Genes in Gastric Cancer in Association with Clinicopathological Characteristics
Conclusion: The obtained data showed the important role of EMT-related genes, Gja1 and Mest1 in the clinical progression of the tumor. Further studies with larger sample sizes are required to confirm these genes as biomarker candidates for detecting gastric cancer.PMID:38680714 | PMC:PMC11055422 | DOI:10.18502/ijhoscr.v18i1.14747 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Nooshin Pourjamal Reza Shirkoohi Elham Rohani Mehrdad Hashemi Source Type: research
CD146 Promotes EMT-Mediated Migration and Invasion of NSCLC via PI3K/Akt Signaling Pathway
CONCLUSIONS: CD146 expression acts as a prognostic risk factor for adverse outcomes in NSCLC, promoting invasion and metastasis by activating the EMT through the PI3K/Akt signaling pathway. These findings underscore the potential therapeutic strategies targeting CD146, offering new treatment options for NSCLC patients, especially those at risk of metastasis.PMID:38682195 | DOI:10.31083/j.fbl2904140 (Source: Cancer Control)
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Nan Wei Xuan Wu Yi Yu Huanhuan Zhou Kai Cui Xingru Zhao Xiaoju Zhang Source Type: research
RNA-binding protein HuR reprograms immune T cells and promotes oral squamous cell carcinoma
We examined HuR's effects on oral malignancies and immune cell function in vitro and in vivo using oral carcinoma cells and transgenic HuR knockout (KO) mice. CRISPR/Cas9-mediated HuR deletion in mice syngeneic oral cancer cells eliminated colony formation and tumor development. HuR-KO tumors had a lower tumor volume, fewer CD4+CD25+FoxP3+ regulatory T cells, and more CD8+ T cells, suggesting that HuR may suppress the immune response during oral cancer progression. In contrast, HuR KO oral epithelial tissues are resistant to 4NQO-induced oral malignancies compared to control tumor-bearing mice. HuR KO mice showed fewer Tre...
Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Mrinmoyee Majumder Harinarayanan Janakiraman Paramita Chakraborty Anitha Vijayakumar Sari Mayhue Hong Yu Toros Dincman Romeo Martin Elizabeth O'Quinn Shikhar Mehrotra Viswanathan Palanisamy Source Type: research
In Vitro Antiviral and Anticancer Effects of Tanacetum sinaicum Essential Oil on Human Cervical and Breast Cancer
CONCLUSION: Tanacetum sinaicum EO is a prospective source of natural bioactive compounds that can be employed in pharmaceutical and medicinal applications due to its antiviral, antiproliferative, anti-metastatic and genotoxic properties.PMID:38680008 | DOI:10.31557/APJCP.2024.25.4.1457 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Abeer A Sheashea Fatma A Ahmed Emad El Zayat Bassam W Ebeed Mostafa H Elberry Zeinab K M Hassan Mohamed M Hafez Source Type: research
Expression of CLLD7 and CHC1L Proteins in Oral Epithelial Dysplasia in a Group of Thai Patients
CONCLUSION: The subcellular mislocalization of CLLD7 and CHC1L in OED suggests that the expression of these potential tumor suppressor proteins might be dysregulated during the dysplastic process. The distinct membrane staining of CHC1L observed in OED but not in NOM is a useful characteristic that can be used to separate OED from NOM. Thus, CHC1L may be a good marker to assist in the diagnosis of OED.PMID:38679985 | DOI:10.31557/APJCP.2024.25.4.1257 (Source: Asian Pacific Journal of Cancer Prevention)
Source: Asian Pacific Journal of Cancer Prevention - April 29, 2024 Category: Cancer & Oncology Authors: Patcharanun Wiphakphongpakorn Rachai Juengsomjit Sopee Poomsawat Ounruean Meesakul Bishwa Prakash Bhattarai Boworn Klongnoi Waranun Buajeeb Siribang-On Piboonniyom Khovidhunkit Source Type: research
Dissecting the Mechanisms of Intestinal Immune Homeostasis by Analyzing T-Cell Immune Response in Crohn's Disease and Colorectal Cancer
CONCLUSION: Finally, the analysis of regulon networks revealed several promising candidates for cell-specific transcription factors (TFs). This study focused on the immune molecular mechanism under intestinal diseases. It contributed to the novel insight of depicting a detailed immune landscape and revealing T-cell responding mechanisms in CD and CRC.PMID:38682449 | DOI:10.2174/0115665232294568240201073417 (Source: Current Gene Therapy)
Source: Current Gene Therapy - April 29, 2024 Category: Genetics & Stem Cells Authors: Tianming Jiang Jie Zheng Nana Li Xiaodong Li Jixing He Junde Zhou Boshi Sun Qiang Chi Source Type: research
