CD146 Promotes EMT-Mediated Migration and Invasion of NSCLC via PI3K/Akt Signaling Pathway

CONCLUSIONS: CD146 expression acts as a prognostic risk factor for adverse outcomes in NSCLC, promoting invasion and metastasis by activating the EMT through the PI3K/Akt signaling pathway. These findings underscore the potential therapeutic strategies targeting CD146, offering new treatment options for NSCLC patients, especially those at risk of metastasis.PMID:38682195 | DOI:10.31083/j.fbl2904140

Source: Cancer Control - April 29, 2024 Category: Cancer & Oncology Authors: Nan Wei Xuan Wu Yi Yu Huanhuan Zhou Kai Cui Xingru Zhao Xiaoju Zhang Source Type: research