siRNA treatment targeting integrin α11 overexpressed via EZH2-driven axis inhibits drug-resistant breast cancer progression
CONCLUSION: Our findings elucidate that integrin α11 is upregulated by EZH2, forming a positive feedback circuit involving FAK-GLI-1 and contributing to drug resistance, cancer stem cell survival and EMT. Taken together, the results suggest integrin α11 as a promising prognostic marker and a powerful therapeutic target for drug-resistant breast cancer.PMID:38664825 | DOI:10.1186/s13058-024-01827-4 (Source: Cell Research)
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Prakash Chaudhary Kiran Yadav Ho Jin Lee Keon Wook Kang Jongseo Mo Jung-Ae Kim Source Type: research
PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway
Exp Cell Res. 2024 Apr 23:114056. doi: 10.1016/j.yexcr.2024.114056. Online ahead of print.ABSTRACTIt was reported that within the head and neck cancer (HNC) cell line CAL21 the epithelial-mesenchymal transition (EMT) and cell proliferation were promoted by Urokinase-Type Plasminogen Activator (PLAU) proteinase through TNFRSF12A. Additionally, in this paper HNC cell lines refer to Fadu and Tu686. A novel PLAU-STAT3 axis was found to be involved in HNC cell line proliferation and metastasis. PLAU expression in HNC samples was upregulated, besides, the elevated expression of PLAU was linked to the lower overall survival (OS) ...
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Xiaobo Cui Hongyang Sun Xiaoqing Liu Yunfei Bai Yanping Bai Yanru Cui Boqian Wang Shu Zhang Xin Li Source Type: research
High core 1 β1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma
CONCLUSION: Elevated C1GALT1 expression in LUAD is associated with an unfavorable prognosis and contributes to increased radioresistance potentially by affecting DNA repair, cell proliferation, cell cycle regulation, and epithelial-mesenchymal transition (EMT).PMID:38662050 | DOI:10.1007/s00432-024-05745-y (Source: Cell Research)
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Yong Chen Yanyan Ji Lin Shen Ying Li Yue Ren Hongcan Shi Yue Li Yunjiang Wu Source Type: research
Defining the in vivo role of mTORC1 in thyrocytes by studying the TSC2 conditional knockout mouse model
CONCLUSIONS: Our thyrocyte-specific mouse model reveals that mTORC1 activation inhibits TH biosynthesis, suppresses thyrocyte gene expression, and promotes growth and proliferation.PMID:38661550 | DOI:10.1089/thy.2024.0053 (Source: Thyroid : official journal of the American Thyroid Association)
Source: Thyroid : official journal of the American Thyroid Association - April 25, 2024 Category: Endocrinology Authors: Camila Ludke Rossetti Bruna Lourenconi Alves Flavia Leticia Martins Pecanha Aime Franco Vania Nos é Everardo Magalh ães Carneiro John I Lew Ernesto Bernal-Mizrachi Joao Pedro Werneck de Castro Source Type: research
High core 1beta1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma
CONCLUSION: Elevated C1GALT1 expression in LUAD is associated with an unfavorable prognosis and contributes to increased radioresistance potentially by affecting DNA repair, cell proliferation, cell cycle regulation, and epithelial-mesenchymal transition (EMT).PMID:38662050 | DOI:10.1007/s00432-024-05745-y (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 25, 2024 Category: Cancer & Oncology Authors: Yong Chen Yanyan Ji Lin Shen Ying Li Yue Ren Hongcan Shi Yue Li Yunjiang Wu Source Type: research
Inhibition of neuraminidase-1 sialidase activity by interfering peptides impairs insulin receptor activity in vitro and glucose homeostasis in vivo
In this study, we investigated the effects of these peptides on IR activation in vitro and in vivo. Using cellular overexpression and endogenous expression models of NEU-1 and IR (COS-7 and HepG2 cells respectively), we have shown that interfering peptides inhibit NEU-1 dimerization and sialidase activity which results in a reduction of IR phosphorylation. These results demonstrated that NEU-1 positively regulates IR phosphorylation and activation in our conditions. In vivo, biodistribution study showed that interfering peptides are well distributed in mice. Treatment of C57Bl/6 mice during eight weeks with interfering pep...
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Kevin Toussaint Aline Appert-Collin Laetitia Vanalderwiert Camille Bour Christine Terryn Caroline Spenl é Micha ël Van Der Heyden Mathilde Roumieux Pascal Maurice B éatrice Romier-Crouzet Herv é Sartelet Laurent Duca S ébastien Blaise Amar Bennasroun Source Type: research
Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells
CONCLUSION: Taken together, we provided the potential mechanism for treating ATC cells with honokiol, which significantly suppresses tumor proliferation and inhibits tumor metastasis in vitro through reactive oxygen species (ROS) induction.PMID:38659261 | DOI:10.2174/0118715303295608240408082523 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 25, 2024 Category: Endocrinology Authors: Kai-Sheng Liao Ying-Ray Lee Wen-Ying Chao Yen-Ju Huang Hui-Chen Chung Shu-Hsin Chen Yi-Zhen Li Pei-Wen Zhao Hong-Yi Chang Source Type: research
Retraction: Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer
J Cell Mol Med. 2024 Apr;28(8):e18312. doi: 10.1111/jcmm.18312.ABSTRACTZhi-Dong Lv, Zhao-Chuan Yang, Xiang-Ping Liu, Li-Ying Jin, Qian Dong, Hui-Li Qu, Fu-Nian Li, Bin Kong, Jiao Sun, Jiao-Jiao Zhao, Hai-Bo Wang, Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 1640-1650. https://doi.org/10.1111/jcmm.12856 The above article, published online on 29 March 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-i...
Source: J Cell Mol Med - April 25, 2024 Category: Molecular Biology Source Type: research
A Genuinely Hybrid, Multiscale 3D Cancer Invasion and Metastasis Modelling Framework
Bull Math Biol. 2024 Apr 25;86(6):64. doi: 10.1007/s11538-024-01286-0.ABSTRACTWe introduce in this paper substantial enhancements to a previously proposed hybrid multiscale cancer invasion modelling framework to better reflect the biological reality and dynamics of cancer. These model updates contribute to a more accurate representation of cancer dynamics, they provide deeper insights and enhance our predictive capabilities. Key updates include the integration of porous medium-like diffusion for the evolution of Epithelial-like Cancer Cells and other essential cellular constituents of the system, more realistic modelling o...
Source: Bulletin of Mathematical Biology - April 25, 2024 Category: Bioinformatics Authors: Dimitrios Katsaounis Nicholas Harbour Thomas Williams Mark Aj Chaplain Nikolaos Sfakianakis Source Type: research
Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells
CONCLUSION: Taken together, we provided the potential mechanism for treating ATC cells with honokiol, which significantly suppresses tumor proliferation and inhibits tumor metastasis in vitro through reactive oxygen species (ROS) induction.PMID:38659261 | DOI:10.2174/0118715303295608240408082523 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 25, 2024 Category: Drugs & Pharmacology Authors: Kai-Sheng Liao Ying-Ray Lee Wen-Ying Chao Yen-Ju Huang Hui-Chen Chung Shu-Hsin Chen Yi-Zhen Li Pei-Wen Zhao Hong-Yi Chang Source Type: research
Retraction: Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer
J Cell Mol Med. 2024 Apr;28(8):e18312. doi: 10.1111/jcmm.18312.ABSTRACTZhi-Dong Lv, Zhao-Chuan Yang, Xiang-Ping Liu, Li-Ying Jin, Qian Dong, Hui-Li Qu, Fu-Nian Li, Bin Kong, Jiao Sun, Jiao-Jiao Zhao, Hai-Bo Wang, Silencing of Prrx1b suppresses cellular proliferation, migration, invasion and epithelial-mesenchymal transition in triple-negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 1640-1650. https://doi.org/10.1111/jcmm.12856 The above article, published online on 29 March 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-i...
Source: Molecular Medicine - April 25, 2024 Category: Molecular Biology Source Type: research
PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway
Exp Cell Res. 2024 Apr 23:114056. doi: 10.1016/j.yexcr.2024.114056. Online ahead of print.ABSTRACTIt was reported that within the head and neck cancer (HNC) cell line CAL21 the epithelial-mesenchymal transition (EMT) and cell proliferation were promoted by Urokinase-Type Plasminogen Activator (PLAU) proteinase through TNFRSF12A. Additionally, in this paper HNC cell lines refer to Fadu and Tu686. A novel PLAU-STAT3 axis was found to be involved in HNC cell line proliferation and metastasis. PLAU expression in HNC samples was upregulated, besides, the elevated expression of PLAU was linked to the lower overall survival (OS) ...
Source: Experimental Cell Research - April 25, 2024 Category: Cytology Authors: Xiaobo Cui Hongyang Sun Xiaoqing Liu Yunfei Bai Yanping Bai Yanru Cui Boqian Wang Shu Zhang Xin Li Source Type: research
Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells
CONCLUSION: Taken together, we provided the potential mechanism for treating ATC cells with honokiol, which significantly suppresses tumor proliferation and inhibits tumor metastasis in vitro through reactive oxygen species (ROS) induction.PMID:38659261 | DOI:10.2174/0118715303295608240408082523 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 25, 2024 Category: Endocrinology Authors: Kai-Sheng Liao Ying-Ray Lee Wen-Ying Chao Yen-Ju Huang Hui-Chen Chung Shu-Hsin Chen Yi-Zhen Li Pei-Wen Zhao Hong-Yi Chang Source Type: research
Honokiol Suppresses Cell Proliferation and Tumor Migration through ROS in Human Anaplastic Thyroid Cancer Cells
CONCLUSION: Taken together, we provided the potential mechanism for treating ATC cells with honokiol, which significantly suppresses tumor proliferation and inhibits tumor metastasis in vitro through reactive oxygen species (ROS) induction.PMID:38659261 | DOI:10.2174/0118715303295608240408082523 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 25, 2024 Category: Drugs & Pharmacology Authors: Kai-Sheng Liao Ying-Ray Lee Wen-Ying Chao Yen-Ju Huang Hui-Chen Chung Shu-Hsin Chen Yi-Zhen Li Pei-Wen Zhao Hong-Yi Chang Source Type: research
PLAU promotes cell proliferation and migration of head and neck cancer via STAT3 signaling pathway
Exp Cell Res. 2024 Apr 23:114056. doi: 10.1016/j.yexcr.2024.114056. Online ahead of print.ABSTRACTIt was reported that within the head and neck cancer (HNC) cell line CAL21 the epithelial-mesenchymal transition (EMT) and cell proliferation were promoted by Urokinase-Type Plasminogen Activator (PLAU) proteinase through TNFRSF12A. Additionally, in this paper HNC cell lines refer to Fadu and Tu686. A novel PLAU-STAT3 axis was found to be involved in HNC cell line proliferation and metastasis. PLAU expression in HNC samples was upregulated, besides, the elevated expression of PLAU was linked to the lower overall survival (OS) ...
Source: Experimental Cell Research - April 25, 2024 Category: Cytology Authors: Xiaobo Cui Hongyang Sun Xiaoqing Liu Yunfei Bai Yanping Bai Yanru Cui Boqian Wang Shu Zhang Xin Li Source Type: research
