Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.PMID:38693424 | DOI:10.1007/s10238-024-01355-7 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Xiao-Ping Fu Chun-Yan Ji Wen-Qian Tang Ting-Ting Yu Lei Luo Source Type: research
Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis
British Journal of Cancer, Published online: 01 May 2024; doi:10.1038/s41416-024-02699-3Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis (Source: British Journal of Cancer)
Source: British Journal of Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Luke B. Villareal Daniel M. Falcon Liwei Xie Xiang Xue Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: J Cell Mol Med - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
The role of anoctamin 1 in liver disease
J Cell Mol Med. 2024 May;28(9):e18320. doi: 10.1111/jcmm.18320.ABSTRACTLiver diseases include all types of viral hepatitis, alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD), cirrhosis, liver failure (LF) and hepatocellular carcinoma (HCC). Liver disease is now one of the leading causes of disease and death worldwide, which compels us to better understand the mechanisms involved in the development of liver diseases. Anoctamin 1 (ANO1), a calcium-activated chloride channel (CaCC), plays an important role in epithelial cell secretion, proliferation and migration. ANO1 plays a key role in transcriptional...
Source: Molecular Medicine - April 30, 2024 Category: Molecular Biology Authors: Xin Li Yongfeng Wang Li Zhang Shun Yao Qian Liu Hai Jin Biguang Tuo Source Type: research
Local therapy combined with anti-PD-1 immunotherapy for advanced lung adenocarcinoma: A case report
J Cancer Res Ther. 2024 Apr 1;20(2):739-744. doi: 10.4103/jcrt.jcrt_1600_23. Epub 2024 Apr 30.ABSTRACTLung adenocarcinoma (LUAD) encompasses all lung epithelial cancers except small-cell lung cancer. Although programmed cell death protein 1 (PD-1) inhibitors, such as pembrolizumab, and other Food and Drug Administration-approved immune checkpoint inhibitors, offer new hope for LUAD treatment, LUAD's overall efficacy remains limited. Thus, the combination of immunotherapy with other therapeutic approaches has gained widespread attention. Local therapy is an optimal method for treating many advanced unresectable lung cancers...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Na Wu Xiaoxin Yang Yan Zhai Wei Lu Source Type: research
Epithelial Expressed B7-H4 Drives Differential Immunotherapy Response in Murine and Human Breast Cancer
Cancer Res Commun. 2024 Apr 24;4(4):1120-1134. doi: 10.1158/2767-9764.CRC-23-0468.ABSTRACTCombinations of immune checkpoint inhibitors (ICI, including anti-PD-1/PD-L1) and chemotherapy have been FDA approved for metastatic and early-stage triple-negative breast cancer (TNBC), but most patients do not benefit. B7-H4 is a B7 family ligand with proposed immunosuppressive functions being explored as a cancer immunotherapy target and may be associated with anti-PD-L1 resistance. However, little is known about its regulation and effect on immune cell function in breast cancers. We assessed murine and human breast cancer cells to...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Elizabeth C Wescott Xiaopeng Sun Paula Gonzalez-Ericsson Ann Hanna Brandie C Taylor Violeta Sanchez Juliana Bronzini Susan R Opalenik Melinda E Sanders Julia Wulfkuhle Rosa I Gallagher Henry Gomez Claudine Isaacs Vijaya Bharti John T Wilson Tarah J Ballin Source Type: research
Circ_0003855 involvement of esophageal cancer progression through miR-622/FLOT1
Oncol Res. 2024 Apr 23;32(5):925-931. doi: 10.32604/or.2023.042447. eCollection 2024.ABSTRACTTo confirm the relationship between Circ_0003855 and EC, we purchased the Human esophageal carcinoma cell line Eca109 and normal human esophageal epithelial cells HEEC, and the expression levels of Circ_0003855, miR-622, and FLOT1 were detected. The results show that Circ_0003855 and FLOT1 were highly expressed in Eca109 cells, while miR-622 was lowly expressed (p < 0.05). Subsequently, Circ_0003855 small interfering RNA (si-Circ_0003855) and its negative control (si-NC) were used to detect changes in cellular biological behavio...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Jingjing Tian Xibao Hu Xinrong Zhang Source Type: research
The Epstein-Barr virus-miRNA-BART6-5p regulates TGF- β/SMAD4 pathway to induce glycolysis and enhance proliferation and metastasis of gastric cancer cells
CONCLUSION: In this study, we found that EBV-miRNA-BART6-5p can target SMAD4, effectively increasing glycolysis in gastric cancer cells by regulating the TGF-β/SMAD4 signaling pathway, thereby enhancing the proliferation and metastasis of gastric cancer cells. Our findings may offer new insights into the metabolic aspects of gastric cancer.PMID:38686046 | PMC:PMC11055990 | DOI:10.32604/or.2024.046679 (Source: Cell Research)
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Xuhui Zhao Xiaomin Huang Chunyan Dang Xia Wang Yujiao Qi Hongling Li Source Type: research
Circ_0003855 involvement of esophageal cancer progression through miR-622/FLOT1
Oncol Res. 2024 Apr 23;32(5):925-931. doi: 10.32604/or.2023.042447. eCollection 2024.ABSTRACTTo confirm the relationship between Circ_0003855 and EC, we purchased the Human esophageal carcinoma cell line Eca109 and normal human esophageal epithelial cells HEEC, and the expression levels of Circ_0003855, miR-622, and FLOT1 were detected. The results show that Circ_0003855 and FLOT1 were highly expressed in Eca109 cells, while miR-622 was lowly expressed (p < 0.05). Subsequently, Circ_0003855 small interfering RNA (si-Circ_0003855) and its negative control (si-NC) were used to detect changes in cellular biological behavio...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Jingjing Tian Xibao Hu Xinrong Zhang Source Type: research
