Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer
EMBO Mol Med. 2024 Apr 24. doi: 10.1038/s44321-024-00069-3. Online ahead of print.ABSTRACTPlatinum (PT)-resistant Epithelial Ovarian Cancer (EOC) grows as a metastatic disease, disseminating in the abdomen and pelvis. Very few options are available for PT-resistant EOC patients, and little is known about how the acquisition of PT-resistance mediates the increased spreading capabilities of EOC. Here, using isogenic PT-resistant cells, genetic and pharmacological approaches, and patient-derived models, we report that Integrin α6 (ITGA6) is overexpressed by PT-resistant cells and is necessary to sustain EOC metastatic abilit...
Source: Molecular Medicine - April 24, 2024 Category: Molecular Biology Authors: Alice Gambelli Anna Nespolo Gian Luca Rampioni Vinciguerra Eliana Pivetta Ilenia Pellarin Milena S Nicoloso Chiara Scapin Linda Stefanatti Ilenia Segatto Andrea Favero Sara D'Andrea Maria Teresa Mucignat Michele Bartoletti Emilio Lucia Monica Schiappacass Source Type: research
Retraction: miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer
J Cell Mol Med. 2024 Apr;28(8):e18314. doi: 10.1111/jcmm.18314.ABSTRACTZhi-Dong Lv, Bin Kong, Xiang-Ping Liu, Li-Ying Jin, Qian Dong, Fu-Nian Li, Hai-Bo Wang, miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 864-873. https://doi.org/10.1111/jcmm.12770 The above article, published online on 28 January 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Stefan Constantinescu, The Foundation for Cellular and Molecular Medicine, and John...
Source: Molecular Medicine - April 24, 2024 Category: Molecular Biology Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Assessment of Portuguese fitness centers: bridging the knowledge gap on harmful microbial contamination with focus on fungi
This study intends to characterize microbial contamination in Portuguese FC by passive sampling methods: electrostatic dust collectors (EDC) (N=39), settled dust (N=8), vacuum filters (N=8), and used cleaning mops (N=12). The obtained extracts were plated in selective culture media for fungi and bacteria. Filters, EDC, and mop samples' extracts were also screened for antifungal resistance and used for the molecular detection of the selected Aspergillus sections. The detection of mycotoxins was conducted using a high-performance liquid chromatograph (HPLC) system and to determine the cytotoxicity of microbial contaminants r...
Source: Environmental Pollution - April 24, 2024 Category: Environmental Health Authors: Carla Viegas C átia Peixoto Bianca Gomes Marta Dias Renata Cervantes Pedro Pena Klara Slezakova Maria do Carmo Pereira Simone Morais Elisabete Carolino Magdalena Twaru żek Susana Viegas Liliana Aranha Caetano Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Cancers, Vol. 16, Pages 1631: Laparoscopic Treatment of Bulky Nodes in Primary and Recurrent Ovarian Cancer: Surgical Technique and Outcomes from Two Specialized Italian Centers
Conclusions: The results of our study are consistent with those reported in the literature, demonstrating that MIS may represent a safe approach in advanced and recurrent EOC with nodal metastasis if performed on selected patients by expert surgeons with an adequate setting and appropriate technique. (Source: Cancers)
Source: Cancers - April 24, 2024 Category: Cancer & Oncology Authors: Alberto Daniele Roberta Rosso Marcello Ceccaroni Giovanni Roviglione Gianmarco D ’Ancona Elisa Peano Valentino Clignon Valerio Calandra Andrea Puppo Tags: Article Source Type: research
Diagnosing and staging epithelial ovarian cancer by serum glycoproteomic profiling
British Journal of Cancer, Published online: 24 April 2024; doi:10.1038/s41416-024-02644-4Diagnosing and staging epithelial ovarian cancer by serum glycoproteomic profiling (Source: British Journal of Cancer)
Source: British Journal of Cancer - April 24, 2024 Category: Cancer & Oncology Authors: Chirag Dhar Prasanna Ramachandran Gege Xu Chad Pickering Tomislav Čaval Maurice Wong Rachel Rice Bo Zhou Apoorva Srinivasan Paul Aiyetan Chih-Wei Chu Kaitlyn Moser Thomas J. Herzog Alexander Babatunde Olawaiye Francis Jacob Daniel Serie Klaus Lindpaintne Source Type: research
Human NLRC4 promotes cancer survival and is associated to type-I interferon signaling and immune infiltration
J Clin Invest. 2024 Apr 23:e166085. doi: 10.1172/JCI166085. Online ahead of print.ABSTRACTThe immune system can control cancer progression. However, even though some innate immune sensors of cellular stress are expressed intrinsically in epithelial cells, their potential role in cancer aggressiveness and subsequent overall survival in humans is mainly unknown. Here, we show that NLR family CARD Domain Containing 4 (NLRC4) is downregulated in epithelial tumor cells of colorectal cancer (CRC) patients by using spatial tissue imaging. Strikingly, only the loss of tumor NLRC4 but not stromal is associated with poor immune infi...
Source: Clinical Lung Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Charlotte Domblides Steven Crampton Hong Liu Juliet M Bartleson Annie Nguyen Claudia Champagne Emily E Landy Lindsey Spiker Christopher Proffitt Sunil Bhattarai Anissa P Grawe Matias Fuentealba Valenzuela Lydia Lartigue Isabelle Mahouche Jeremy Dupaul-Chi Source Type: research
Human NLRC4 promotes cancer survival and is associated to type-I interferon signaling and immune infiltration
J Clin Invest. 2024 Apr 23:e166085. doi: 10.1172/JCI166085. Online ahead of print.ABSTRACTThe immune system can control cancer progression. However, even though some innate immune sensors of cellular stress are expressed intrinsically in epithelial cells, their potential role in cancer aggressiveness and subsequent overall survival in humans is mainly unknown. Here, we show that NLR family CARD Domain Containing 4 (NLRC4) is downregulated in epithelial tumor cells of colorectal cancer (CRC) patients by using spatial tissue imaging. Strikingly, only the loss of tumor NLRC4 but not stromal is associated with poor immune infi...
Source: Clinical Colorectal Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Charlotte Domblides Steven Crampton Hong Liu Juliet M Bartleson Annie Nguyen Claudia Champagne Emily E Landy Lindsey Spiker Christopher Proffitt Sunil Bhattarai Anissa P Grawe Matias Fuentealba Valenzuela Lydia Lartigue Isabelle Mahouche Jeremy Dupaul-Chi Source Type: research
Histopathological tumour microenvironment score independently predicts outcome in primary operable colorectal cancer
In conclusion, TMS represents a novel and clinically relevant method for subtyping CRC patients from a single H&E-stained tumour section.PMID:38650367 | DOI:10.1002/2056-4538.12374 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Phimmada Hatthakarnkul Kathryn Pennel Peter Alexander Hester van Wyk Antonia Roseweir Jitwadee Inthagard Jennifer Hay Ditte Andersen Noori Maka James Park Campbell Roxburgh Chanitra Thuwajit Donald McMillan Joanne Edwards Source Type: research
