High core 1 β1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma
ConclusionElevated C1GALT1 expression in LUAD is associated with an unfavorable prognosis and contributes to increased radioresistance potentially by affecting DNA repair, cell proliferation, cell cycle regulation, and epithelial –mesenchymal transition (EMT). (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1662: The Causes and Consequences of DNA Damage and Chromosomal Instability Induced by Human Papillomavirus
Mehta
Cosper
High-risk human papillomaviruses (HPVs) are the main cause of cervical, oropharyngeal, and anogenital cancers, which are all treated with definitive chemoradiation therapy when locally advanced. HPV proteins are known to exploit the host DNA damage response to enable viral replication and the epithelial differentiation protocol. This has far-reaching consequences for the host genome, as the DNA damage response is critical for the maintenance of genomic stability. HPV+ cells therefore have increased DNA damage, leading to widespread genomic instability, a hallmark of cancer, which can contribute to tumo...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Jones Bryan McCunn Lantz Blalock Ojeda Mehta Cosper Tags: Review Source Type: research
Interleukin 33 supports squamous cell carcinoma growth via a dual effect on tumour proliferation, migration and invasion, and T cell activation
AbstractInterleukin (IL)-33 is an important cytokine in the tumour microenvironment; it is known to promote the growth and metastasis of solid cancers, such as gastric, colorectal, ovarian and breast cancer. Our group demonstrated that the IL-33/ST2 pathway enhances the development of squamous cell carcinoma (SCC). Conversely, other researchers have reported that IL-33 inhibits tumour progression. In addition, the crosstalk between IL-33, cancer cells and immune cells in SCC remains unknown. The aim of this study was to investigate the effect of IL-33 on the biology of head and neck SCC lines and to evaluate the impact of ...
Source: Cancer Immunology, Immunotherapy - April 25, 2024 Category: Cancer & Oncology Source Type: research
Retraction: miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer
J Cell Mol Med. 2024 Apr;28(8):e18314. doi: 10.1111/jcmm.18314.ABSTRACTZhi-Dong Lv, Bin Kong, Xiang-Ping Liu, Li-Ying Jin, Qian Dong, Fu-Nian Li, Hai-Bo Wang, miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 864-873. https://doi.org/10.1111/jcmm.12770 The above article, published online on 28 January 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Stefan Constantinescu, The Foundation for Cellular and Molecular Medicine, and John...
Source: J Cell Mol Med - April 24, 2024 Category: Molecular Biology Source Type: research
Retraction: miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer
J Cell Mol Med. 2024 Apr;28(8):e18314. doi: 10.1111/jcmm.18314.ABSTRACTZhi-Dong Lv, Bin Kong, Xiang-Ping Liu, Li-Ying Jin, Qian Dong, Fu-Nian Li, Hai-Bo Wang, miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 864-873. https://doi.org/10.1111/jcmm.12770 The above article, published online on 28 January 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Stefan Constantinescu, The Foundation for Cellular and Molecular Medicine, and John...
Source: Molecular Medicine - April 24, 2024 Category: Molecular Biology Source Type: research
Transforming growth factor-beta signals promote progression of squamous cell carcinoma by inducing epithelial-mesenchymal transition and angiogenesis
In this study, we examined the effects of TGF-β signaling on the murine squamous cell carcinoma, SCCVII cells in vitro and in vivo. The incubation of SCCVII cells with TGF-β induced the activation of TGF-β signals and epithelial-mesenchymal transition (EMT). Notably, the motility of SCCVII cells was increased upon the activation of the TGF-β signaling. RNA sequencing revealed upregulation of genes related to EMT and angiogenesis. Consistent with these in vitro results, the inhibition of TGF-β signals in SCCVII cell-derived primary tumors resulted in suppressed angiogenesis. Furthermore, we identified six candidate fac...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Haruka Ibi Kazuki Takahashi Hiroyuki Harada Tetsuro Watabe Katarzyna A Podyma-Inoue Source Type: research
Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer
Cancer Res. 2024 Apr 24. doi: 10.1158/0008-5472.CAN-23-3264. Online ahead of print.ABSTRACTColorectal cancer (CRC) is one of the most common malignant tumors in humans, with liver metastasis being the primary cause of mortality. The epithelial-mesenchymal transition (EMT) process endows cancer cells with enhanced metastatic potential. To elucidate the cellular mechanisms driving EMT in CRC, we analyzed single-cell RNA-sequencing (scRNA-seq) data from 11 non-metastatic primary tumors (TnM) and 11 metastatic primary tumors (TM) from CRC patients. Compared to TnM group, the TM samples showed elevated numbers of malignant epit...
Source: Cell Research - April 24, 2024 Category: Cytology Authors: Sheng Yang Dongsheng Zhang Qingyang Sun Hongxu Nie Yue Zhang Xiaowei Wang Yuanjian Huang Yueming Sun Source Type: research
Long-term 4-nonylphenol exposure drives cervical cell malignancy through MAPK-mediated ferroptosis inhibition
J Hazard Mater. 2024 Apr 21;471:134371. doi: 10.1016/j.jhazmat.2024.134371. Online ahead of print.ABSTRACT4-NP (4-nonylphenol), a prevalent environmental endocrine disruptor with estrogenic properties, is commonly detected in drinking water and food sources. It poses a significant risk of endocrine disruption, thereby influencing the onset and progression of diverse diseases, including tumorigenesis. However, its specific impact on cervical cancer remains to be fully elucidated. Our study focused on the biological effects of sustained exposure to low-dose 4-NP on human normal cervical epithelial cells (HcerEpic). After a c...
Source: Cancer Control - April 24, 2024 Category: Cancer & Oncology Authors: Xing Zhang Wenjing Yan Xue Chen Xiuting Li Bingjia Yu Yan Zhang Bo Ding Jing Hu Haohan Liu Yamei Nie Fengying Liu Yun Zheng Yiran Lu Jin Wang Shizhi Wang Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
Assessment of Portuguese fitness centers: bridging the knowledge gap on harmful microbial contamination with focus on fungi
This study intends to characterize microbial contamination in Portuguese FC by passive sampling methods: electrostatic dust collectors (EDC) (N=39), settled dust (N=8), vacuum filters (N=8), and used cleaning mops (N=12). The obtained extracts were plated in selective culture media for fungi and bacteria. Filters, EDC, and mop samples' extracts were also screened for antifungal resistance and used for the molecular detection of the selected Aspergillus sections. The detection of mycotoxins was conducted using a high-performance liquid chromatograph (HPLC) system and to determine the cytotoxicity of microbial contaminants r...
Source: Environmental Pollution - April 24, 2024 Category: Environmental Health Authors: Carla Viegas C átia Peixoto Bianca Gomes Marta Dias Renata Cervantes Pedro Pena Klara Slezakova Maria do Carmo Pereira Simone Morais Elisabete Carolino Magdalena Twaru żek Susana Viegas Liliana Aranha Caetano Source Type: research
Transforming growth factor- β signals promote progression of squamous cell carcinoma by inducing epithelial-mesenchymal transition and angiogenesis
In this study, we examined the effects of TGF-β signaling on the murine squamous cell carcinoma, SCCVII cells in vitro and in vivo. The incubation of SCCVII cells with TGF-β induced the activation of TGF-β signals and epithelial-mesenchymal transition (EMT). Notably, the motility of SCCVII cells was increased upon the activation of the TGF-β signaling. RNA sequencing revealed upregulation of genes related to EMT and angiogenesis. Consistent with these in vitro results, the inhibition of TGF-β signals in SCCVII cell-derived primary tumors resulted in suppressed angiogenesis. Furthermore, we identified six candidate fac...
Source: Biochemical and Biophysical Research communications - April 24, 2024 Category: Biochemistry Authors: Haruka Ibi Kazuki Takahashi Hiroyuki Harada Tetsuro Watabe Katarzyna A Podyma-Inoue Source Type: research
Retraction: miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer
J Cell Mol Med. 2024 Apr;28(8):e18314. doi: 10.1111/jcmm.18314.ABSTRACTZhi-Dong Lv, Bin Kong, Xiang-Ping Liu, Li-Ying Jin, Qian Dong, Fu-Nian Li, Hai-Bo Wang, miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 864-873. https://doi.org/10.1111/jcmm.12770 The above article, published online on 28 January 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Stefan Constantinescu, The Foundation for Cellular and Molecular Medicine, and John...
Source: J Cell Mol Med - April 24, 2024 Category: Molecular Biology Source Type: research
Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer
EMBO Mol Med. 2024 Apr 24. doi: 10.1038/s44321-024-00069-3. Online ahead of print.ABSTRACTPlatinum (PT)-resistant Epithelial Ovarian Cancer (EOC) grows as a metastatic disease, disseminating in the abdomen and pelvis. Very few options are available for PT-resistant EOC patients, and little is known about how the acquisition of PT-resistance mediates the increased spreading capabilities of EOC. Here, using isogenic PT-resistant cells, genetic and pharmacological approaches, and patient-derived models, we report that Integrin α6 (ITGA6) is overexpressed by PT-resistant cells and is necessary to sustain EOC metastatic abilit...
Source: Molecular Medicine - April 24, 2024 Category: Molecular Biology Authors: Alice Gambelli Anna Nespolo Gian Luca Rampioni Vinciguerra Eliana Pivetta Ilenia Pellarin Milena S Nicoloso Chiara Scapin Linda Stefanatti Ilenia Segatto Andrea Favero Sara D'Andrea Maria Teresa Mucignat Michele Bartoletti Emilio Lucia Monica Schiappacass Source Type: research
Retraction: miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer
J Cell Mol Med. 2024 Apr;28(8):e18314. doi: 10.1111/jcmm.18314.ABSTRACTZhi-Dong Lv, Bin Kong, Xiang-Ping Liu, Li-Ying Jin, Qian Dong, Fu-Nian Li, Hai-Bo Wang, miR-655 suppresses epithelial-to-mesenchymal transition by targeting Prrx1 in triple-negative breast cancer. Journal of Cellular and Molecular Medicine, 20: 864-873. https://doi.org/10.1111/jcmm.12770 The above article, published online on 28 January 2016 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Stefan Constantinescu, The Foundation for Cellular and Molecular Medicine, and John...
Source: Molecular Medicine - April 24, 2024 Category: Molecular Biology Source Type: research
Single-cell analysis revealing the metabolic landscape of prostate cancer
Asian J Androl. 2024 Apr 23. doi: 10.4103/aja20243. Online ahead of print.ABSTRACTTumor metabolic reprogramming is a hallmark of cancer development, and targeting metabolic vulnerabilities has been proven to be an effective approach for castration-resistant prostate cancer (CRPC) treatment. Nevertheless, treatment failure inevitably occurs, largely due to cellular heterogeneity, which cannot be deciphered by traditional bulk sequencing techniques. By employing computational pipelines for single-cell RNA sequencing, we demonstrated that epithelial cells within the prostate are more metabolically active and plastic than stro...
Source: Asian Journal of Andrology - April 24, 2024 Category: Urology & Nephrology Authors: Jing Wang He-Kang Ding Han-Jiang Xu De-Kai Hu William Hankey Li Chen Jun Xiao Chao-Zhao Liang Bing Zhao Ling-Fan Xu Source Type: research
