Integrating integrins with the hallmarks of cancer
Matrix Biol. 2024 Apr 25:S0945-053X(24)00053-2. doi: 10.1016/j.matbio.2024.04.003. Online ahead of print.ABSTRACTEpithelial cells adhere to a specialized extracellular matrix called the basement membrane which allows them to polarize and form epithelial tissues. The extracellular matrix provides essential physical scaffolding and biochemical and biophysical cues required for tissue morphogenesis, differentiation, function, and homeostasis. Epithelial cell adhesion to the extracellular matrix (i.e., basement membrane) plays a critical role in organizing epithelial tissues, separating the epithelial cells from the stroma. Ep...
Source: Matrix Biology - April 27, 2024 Category: Molecular Biology Authors: Scott M Haake Brenda L Rios Ambra Pozzi Roy Zent Source Type: research
High Twist expression can be an early event in lip carcinogenesis
ConclusionsThe results suggest that the high immunoexpression of Twist is an early lip carcinogenesis event. However, it appears not to influence the progression of ED in AC. (Source: Oral Surgery)
Source: Oral Surgery - April 27, 2024 Category: ENT & OMF Authors: Israel Leal Cavalcante,
Caio César da Silva Barros,
Hellen Bandeira de Pontes Santos,
Amanda Katarinny Goes Gonzaga,
Silvia Helena Barem Rabenhorst,
Roberta Barroso Cavalcante,
Éricka Janine Dantas da Silveira,
Ana Miryam Costa de Medeiros Tags: ORIGINAL ARTICLE Source Type: research
GSE264547 TAZ is involved in breast cancer cell migration via regulating actin dynamics
Conclusion: TAZ knockdown inhibits the migration of breast cancer cells by regulating the intracellular actin cytoskeletal organization. This is achieved, in part, by reducing the abundance of RhoA and Rho-dependent downstream kinase proteins, which results in actin depolymerization and the disassembly of stress fibers and focal adhesions. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 27, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
High-Grade Serous Ovarian Cancer during Pregnancy: From Diagnosis to Treatment
CONCLUSIONS: There have not been long-term follow-ups of patients' oncologic and obstetric outcomes. As patients should be comprehensively informed, more detailed case reports or series with longer follow-up periods are needed.PMID:38668047 | DOI:10.3390/curroncol31040144 (Source: Current Oncology)
Source: Current Oncology - April 26, 2024 Category: Cancer & Oncology Authors: Gregor Vivod Sebastjan Merlo Nina Kovacevic Source Type: research
Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics
This study aimed to carry out a literature review considering several aspects involving HPV infection: Global distribution, prevalence, biology, host interactions, cancer development, prevention, therapeutics, coinfection with other viruses, coinfection with bacteria, association with head and neck squamous cell carcinomas, and association with anal cancer.PMID:38666757 | DOI:10.1002/rmv.2537 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Jonas Wolf Lucas Felipe Kist Samanta Brangel Pereira Marilze Alves Quessada Helena Petek Arthur Pille Ju çara Gasparetto Maccari Mohamed Parrini Mutlaq Luiz Antonio Nasi Source Type: research
Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC)
CONCLUSIONS: Our results demonstrated that TPM2 knockdown suppressed the proliferation of CAC IECs, enhanced immune suppression on CAC IECs, and inhibited the JNK signaling pathway within the framework of CAC. These findings suggest TPM2 can serve as a potential therapeutic target for CAC treatment.PMID:38665026 | DOI:10.24976/Discov.Med.202436183.73 (Source: Cancer Control)
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Aixi Sun Jian Ge Kaixin Ding Zhiyang Gao Yun Zhang Source Type: research
Profiling the molecular and clinical landscape of glioblastoma utilizing the Oncology Research Information Exchange Network brain cancer database
CONCLUSIONS: Herein, we report the first clinical, genomic, and transcriptomic analysis of ORIEN glioblastoma cases, incorporating sample reclassification under updated 2021 diagnostic criteria. These findings create multiple avenues for further investigation and reinforce the value of multi-institutional consortia such as ORIEN in deepening our knowledge of intractable diseases such as glioblastoma.PMID:38665799 | PMC:PMC11044707 | DOI:10.1093/noajnl/vdae046 (Source: Adv Data)
Source: Adv Data - April 26, 2024 Category: Epidemiology Authors: Alexandra N Demetriou Frances Chow David W Craig Michelle G Webb D Ryan Ormond James Battiste Arnab Chakravarti Howard Colman John L Villano Bryan P Schneider James K C Liu Michelle L Churchman Gabriel Zada Source Type: research
Association between < em > KRAS < /em > and < em > PIK3CA < /em > Mutations and Progesterone Resistance in Endometriotic Epithelial Cell Line
In this study, we investigated the effects of these mutations on progesterone resistance. Since the HMOsisEC10 had suppressed progesterone receptor (PR) expression, we transduced PR-B to HMOsisEc10 cell lines including KRAS mutant and PIK3CA mutant cell lines. We conducted a migration assay, invasion assay, and MTT assay using dienogest and medroxyprogestrone acetate. All cell lines showed progesterone sensitivity with or without mutations. Regarding inflammatory factors, real-time quantitative RT-PCR revealed that the KRAS mutation cell line exhibited no suppression of Cox-2 and mPGES-1 on progesterone treatment, whereas ...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Kosuke Kanno Kentaro Nakayama Sultana Razia Sohel Hasibul Islam Zahan Umme Farzana Shahataj Begum Sonia Hitomi Yamashita Masako Ishikawa Tomoka Ishibashi Kayo Imamura Tohru Kiyono Satoru Kyo Source Type: research
Challenges in Defining a Reference Set of Differentially Expressed lncRNAs in Ulcerative Colitis by Meta-Analysis
Curr Issues Mol Biol. 2024 Apr 5;46(4):3164-3174. doi: 10.3390/cimb46040198.ABSTRACTThe study aimed to identify common differentially expressed lncRNAs from manually curated ulcerative colitis (UC) gene expression omnibus (GEO) datasets. Nine UC transcriptomic datasets of clearly annotated human colonic biopsies were included in the study. The datasets were manually curated to select active UC samples and controls. R packages geneknitR, gprofiler, clusterProfiler were used for gene symbol annotation. The R EdgeR package was used to analyze differential expression. This resulted in a total of nineteen lncRNAs that were diff...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Christopher G Fenton Mithlesh Kumar Ray Ruth H Paulssen Source Type: research
Frankincense ( < em > Boswellia serrata < /em > ) Extract Effects on Growth and Biofilm Formation of < em > Porphyromonas gingivalis < /em > , and Its Intracellular Infection in Human Gingival Epithelial Cells
Curr Issues Mol Biol. 2024 Mar 30;46(4):2991-3004. doi: 10.3390/cimb46040187.ABSTRACTFrankincense is produced by Boswellia trees, which can be found throughout the Middle East and parts of Africa and Asia. Boswellia serrata extract has been shown to have anti-cancer, anti-inflammatory, and antimicrobial effects. Periodontitis is an oral chronic inflammatory disease that affects nearly half of the US population. We investigated the antimicrobial effects of B. serrata extract on two oral pathogens associated with periodontitis. Using the minimum inhibitory concentration and crystal violet staining methods, we demonstrated th...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: David Vang Aline Cristina Abreu Moreira-Souza Nicholas Zusman German Moncada Harmony Matshik Dakafay Homer Asadi David M Ojcius Cassio Luiz Coutinho Almeida-da-Silva Source Type: research
The effectiveness of CA125 and HE4 as clinical prognostic markers in epithelial ovarian cancer patients with BRCA mutation
CONCLUSION: Normalizing both biomarkers emerged as the most effective predictive marker for the 1-year recurrence rate, regardless of BRCA mutational status. A negative HE4 value can be a useful predictor for 1-year recurrence-free survival in patients with BRCA mutations.PMID:38670560 | DOI:10.3802/jgo.2024.35.e80 (Source: Journal of Gynecologic Oncology)
Source: Journal of Gynecologic Oncology - April 26, 2024 Category: OBGYN Authors: Young Joo Lee Woojin Kim Soomin Hong Yong Jae Lee Jung-Yun Lee Sang Wun Kim Sunghoon Kim Young Tae Kim Eun Ji Nam Source Type: research
Association between KRAS and PIK3CA Mutations and Progesterone Resistance in Endometriotic Epithelial Cell Line
In this study, we investigated the effects of these mutations on progesterone resistance. Since the HMOsisEC10 had suppressed progesterone receptor (PR) expression, we transduced PR-B to HMOsisEc10 cell lines including KRAS mutant and PIK3CA mutant cell lines. We conducted a migration assay, invasion assay, and MTT assay using dienogest and medroxyprogestrone acetate. All cell lines showed progesterone sensitivity with or without mutations. Regarding inflammatory factors, real-time quantitative RT-PCR revealed that the KRAS mutation cell line exhibited no suppression of Cox-2 and mPGES-1 on progesterone treatment, whereas ...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Kosuke Kanno Kentaro Nakayama Sultana Razia Sohel Hasibul Islam Zahan Umme Farzana Shahataj Begum Sonia Hitomi Yamashita Masako Ishikawa Tomoka Ishibashi Kayo Imamura Tohru Kiyono Satoru Kyo Source Type: research
Challenges in Defining a Reference Set of Differentially Expressed lncRNAs in Ulcerative Colitis by Meta-Analysis
Curr Issues Mol Biol. 2024 Apr 5;46(4):3164-3174. doi: 10.3390/cimb46040198.ABSTRACTThe study aimed to identify common differentially expressed lncRNAs from manually curated ulcerative colitis (UC) gene expression omnibus (GEO) datasets. Nine UC transcriptomic datasets of clearly annotated human colonic biopsies were included in the study. The datasets were manually curated to select active UC samples and controls. R packages geneknitR, gprofiler, clusterProfiler were used for gene symbol annotation. The R EdgeR package was used to analyze differential expression. This resulted in a total of nineteen lncRNAs that were diff...
Source: Mol Biol Cell - April 26, 2024 Category: Molecular Biology Authors: Christopher G Fenton Mithlesh Kumar Ray Ruth H Paulssen Source Type: research
Tropomyosin 2 Regulates Tumor Cell Proliferation, Immune Suppression, and Activation of the JNK Signaling Pathway in Colitis-Associated Cancer (CAC)
CONCLUSIONS: Our results demonstrated that TPM2 knockdown suppressed the proliferation of CAC IECs, enhanced immune suppression on CAC IECs, and inhibited the JNK signaling pathway within the framework of CAC. These findings suggest TPM2 can serve as a potential therapeutic target for CAC treatment.PMID:38665026 | DOI:10.24976/Discov.Med.202436183.73 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Aixi Sun Jian Ge Kaixin Ding Zhiyang Gao Yun Zhang Source Type: research
Epithelial-Mesenchymal Transformation Promotes the Progression of Hepatocellular Carcinoma through NF- κB/MMP9 Axis
CONCLUSIONS: The NF-κB/MMP9 signaling axis serves as a pivotal regulator that fosters proliferation and impedes apoptosis in Huh7 cells by modulating the process of EMT.PMID:38665016 | DOI:10.24976/Discov.Med.202436183.63 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Jinsen Li Qingbin Cai Ziyue Wang Liangshi Wang Guangrun Yang Zhilong Zhang Na Ge Shunxin Hu Tian Bai Source Type: research
