Ultrasound image features of intravesical prostatic protrusion indicated failure of medication therapy of finasteride and doxazosin in patients with benign prostatic hyperplasia (LUTS/BPH)
ConclusionsThe study indicated that the combination therapy using finasteride and doxazosin could not reduce the degree of IPP. LUTS/BPH patients with IPP which contributes to the failure of medication tend to have a higher risk of progression. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - December 15, 2016 Category: Urology & Nephrology Source Type: research
[Combined treatment of BPS with tamsulosin and finasteride : Literature review and prescription data].
Abstract
Combined therapy of benign prostatic syndrome (BPS) with α1-blockers and 5α-reductase (5AR)-inhibitors is recommended according to two leading studies on doxazosin/finasteride and tamsulosin/dutasteride for all 10 in Germany possible combinations (five α1-blockers and two 5AR inhibitors). Because tamsulosin and finasteride predominate in the treatment of BPS in Germany, the role of the combination tamsulosin/finasteride and its scientific basis from clinical studies has been investigated. A pharmacoepidemiological extrapolation from receipts of pharmacy data centres showed a strong increase o...
Source: Der Urologe. Ausg. A - December 14, 2016 Category: Urology & Nephrology Authors: Höfner K, Ulrich S, Berges R Tags: Urologe A Source Type: research
The effects of alpha 1-adrenoceptor-blockade and angiotensin converting enzyme-inhibition on indices of aortic stiffness measured by an oscillometric single cuff method in hypertension: the doxazosin ramipril study
Objectives: To study whether inhibition of the renin-angiotensin-aldosterone system has effects on arterial stiffness beyond blood pressure (BP) reduction alone. (Source: Artery Research)
Source: Artery Research - November 25, 2016 Category: Cardiology Authors: Andreas Jekell, Majid Kalani, Thomas Kahan Source Type: research
Effect of Doxazosin on Autonomic Nervous Control and Urodynamics of Rat Urinary Bladder during Modeled Infravesical Obstruction
The therapeutic effect of doxazosin (40 μg/kg/day over one month) on urinary bladder was examined in female rats with modeled chronic infravesical obstruction (IVO) produced by graduated mechanical constriction of the proximal urethral segment. In one month, IVO induced a pronounced vesical hypertrophy both in treated and untreated rats that manifested in increased bladder weight and capacity, the latter increment being pronouncedly greater in treated rats. In untreated IVO rats, infusion cystometry revealed elevated basal intravesical pressure of void bladder P0, markedly increased maximal (premicturitional) pressure Pma...
Source: Bulletin of Experimental Biology and Medicine - October 4, 2016 Category: Biology Source Type: research
Doxazosin oral intake therapy to relieve stent - related urinary symptoms and pain: a prospective, randomized, controlled study
Conclusions: Doxazosin Oral Intake Therapy reduced stent-related urinary symptoms, pain and the negative impact on QoL. (Source: International Braz J Urol)
Source: International Braz J Urol - September 9, 2016 Category: Urology & Nephrology Source Type: research
Interactions between medications employed in treating benign prostatic hyperplasia and food − A short review
Publication date: October 2016 Source:Biomedicine & Pharmacotherapy, Volume 83 Author(s): Paweł Paśko, Tomasz Rodacki, Renata Domagała-Rodacka, Danuta Owczarek Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. BPH symptoms include frequent urination, urgent tenesmus and urination at night, a weak and interrupted urine flow and a sense of incomplete emptying of the bladder. Alpha- 1 adrenergic receptor antagonists and 5 α-reductase inhibitors form the most important groups of medications employed in BPH. Appropriately managed BPH patients shall be subject to counselling on inter...
Source: Biomedicine and Pharmacotherapy - August 20, 2016 Category: Drugs & Pharmacology Source Type: research
Interactions between medications employed in treating benign prostatic hyperplasia and food - A short review.
Abstract
Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. BPH symptoms include frequent urination, urgent tenesmus and urination at night, a weak and interrupted urine flow and a sense of incomplete emptying of the bladder. Alpha- 1 adrenergic receptor antagonists and 5 α-reductase inhibitors form the most important groups of medications employed in BPH. Appropriately managed BPH patients shall be subject to counselling on interactions between agents belonging to these groups, and on particular components of the food they have. The present review has been aimed at assessing po...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 19, 2016 Category: Drugs & Pharmacology Authors: Paśko P, Rodacki T, Domagała-Rodacka R, Owczarek D Tags: Biomed Pharmacother Source Type: research
UHPLC –MS/MS method with protein precipitation extraction for the simultaneous quantification of ten antihypertensive drugs in human plasma from resistant hypertensive patients
Publication date: 10 September 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 129 Author(s): Amedeo De Nicolò, Valeria Avataneo, Franco Rabbia, Gabriele Bonifacio, Jessica Cusato, Cristina Tomasello, Elisa Perlo, Paolo Mulatero, Franco Veglio, Giovanni Di Perri, Antonio D’Avolio Today the management of resistant hypertension is a critical health problem: the main difficulty on this field is the discrimination of cases of poor therapeutic adherence from cases of real resistance. This gives rise to the need of high throughput and reliable quantification methods for the Therapeutic Drug ...
Source: Journal of Pharmaceutical and Biomedical Analysis - August 4, 2016 Category: Drugs & Pharmacology Source Type: research
α-Blockers, 5-α-Reductase Inhibitors, Acetylcholine, β3 Agonists, and Phosphodiesterase-5s in Medical Management of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia: How Much Do the Different Formulations Actually Matter in the Classes?
Abstract
Many monotherapies are currently available to clinically treat and alleviate symptoms of lower urinary tract symptoms secondary to benign prostatic hyperplasia: α-blockers, 5ARIs, PDE5Is, β-3-andrenoceptor agonists, and anticholinergic agents. Current studies have evaluated the effective of these treatments in comparison to other groups or in combination therapies. The current review evaluates the effectiveness of class formulations. Based on the findings, α-blockers, specifically doxazosin and terazosin, were most effective in reducing IPSS scores and peak urinary flow rate, while being most c...
Source: The Urologic Clinics of North America - July 31, 2016 Category: Urology & Nephrology Authors: Chughtai B, Thomas D, Kaplan S Tags: Urol Clin North Am Source Type: research
α-Blockers, 5-α-Reductase Inhibitors, Acetylcholine, β3 Agonists, and Phosphodiesterase-5s in Medical Management of Lower Urinary Tract Symptoms/Benign Prostatic Hyperplasia
Many monotherapies are currently available to clinically treat and alleviate symptoms of lower urinary tract symptoms secondary to benign prostatic hyperplasia: α-blockers, 5ARIs, PDE5Is, β-3-andrenoceptor agonists, and anticholinergic agents. Current studies have evaluated the effective of these treatments in comparison to other groups or in combination therapies. The current review evaluates the effectiveness of class formulations. Based on the findings , α-blockers, specifically doxazosin and terazosin, were most effective in reducing IPSS scores and peak urinary flow rate, while being most cost-effective. However, f...
Source: Urologic Clinics of North America - July 28, 2016 Category: Urology & Nephrology Authors: Bilal Chughtai, Dominique Thomas, Steven Kaplan Source Type: research
Validation and utility of the PhysioTel ™ Digital M11 telemetry implant for cardiovascular data evaluation in cynomolgus monkeys and Beagle dogs
Discussion Based upon the results of this study, the PhysioTel™ Digital M11 is a suitable technology for assessing cardiovascular parameters in monkeys and dogs, and because of the size and limited invasiveness of the implant, is well positioned for use on toxicology studies. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 20, 2016 Category: Drugs & Pharmacology Source Type: research
Highly Sensitive Fluorescence Methods for the Determination of Alfuzosin, Doxazosin, Terazosin and Prazosin in Pharmaceutical Formulations, Plasma and Urine.
Abstract
Polymeric ionic liquid-coated magnetic nanoparticles have been successfully prepared as adsorbents for the magnetic solid-phase extraction of four drugs, namely alfuzosin, doxazosin, terazosin and prazosin, from pharmaceutical preparations, urine samples and plasma samples. The four drugs were detected by fluorescence spectrophotometer. Several extraction parameters, including the pH of the solution; the type, ratio and volume of the desorbing reagent; the amount of adsorbent; the time of the extraction and desorption processes; and the addition of NaCl, were investigated and optimized. Linear res...
Source: Anal Sci - July 12, 2016 Category: Chemistry Authors: Guo X, Wu H, Guo S, Shi Y, DU J, Zhu P, DU L Tags: Anal Sci Source Type: research
Doxazosin, an α-1-adrenergic-receptor Antagonist, for Nightmares in Patients with Posttraumatic Stress Disorder and/or Borderline Personality Disorder: a Chart Review
Conclusion: Doxazosin might improve trauma associated nightmares and more general sleep parameters in patients with PTSD and BPD. Randomized controlled trials are warranted.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 7, 2016 Category: Psychiatry Authors: Roepke, S.Danker-Hopfe, H.Repantis, D.Behnia, B.Bernard, F.Hansen, M.-L.Otte, C. Tags: Original Paper Source Type: research
A Randomized, Open-Label, Comparative Study of Efficacy and Safety of Tolterodine Combined with Tamsulosin or Doxazosin in Patients with Benign Prostatic Hyperplasia.
CONCLUSIONS Administration of alpha blockers combined with muscarinic receptor blocker for 12 weeks improved LUTS in men with BPH.
PMID: 27260129 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 6, 2016 Category: Research Tags: Med Sci Monit Source Type: research
Doxazosin XL reduces symptoms of posttraumatic stress disorder in veterans with PTSD: a pilot clinical trial.
CONCLUSIONS: Doxazosin XL may be an effective alternative to prazosin for the treatment of some PTSD symptoms.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier:NCT02308202.
PMID: 27249080 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2016 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
