Interaction studies on catecholamines to cellular receptors using in silico approach
Catecholamines are organic compounds derived from amino acids tyrosine and phenylalanine, which acts as neurotransmitters and also functions as hormones in the blood circulation. They bind to plasma proteins and circulate in the blood stream. High levels of catecholamines will cause increase in the heart rate, blood pressure and blood glucose level. These effects are due to binding of catecholamines with adrenergic receptors. Therefore the objective of the current research work is to know the binding affinity of catecholamines with adrenergic receptors through in silico approach. (Source: Artery Research)
Source: Artery Research - June 27, 2017 Category: Cardiology Authors: S. Kalaivannan, T. Vinoth kambali, S. Prabhu, S. Visvanathan, N. Karpagam Source Type: research
The acute effect of maximal aerobic and isometric exercise on arterial stiffness parameters in boys and men
To evaluate whether the acute effects of aerobic or isometric exercise on arterial stiffness parameters differ between boys and men. (Source: Artery Research)
Source: Artery Research - May 23, 2017 Category: Cardiology Authors: Elizabeth C. Schroeder, Sushant M. Ranadive, Kevin S. Heffernan, Sae Young Jae, Bo Fernhall Tags: Short communication Source Type: research
Vascular dysfunction: At the heart of cardiovascular disease, cognitive impairment and depressive symptoms
Vascular dysfunction may be an important pathway through which ageing and other factors, such as diabetes and obesity, can cause diseases of the heart and brain. Vascular dysfunction includes dysfunction of large arteries (due to arterial stiffness), the microcirculation (microvascular dysfunction) and endothelium (endothelial dysfunction). We have investigated, in a series of epidemiological studies, the role of vascular dysfunction in the pathogenesis of cardiovascular disease, dementia and depression. (Source: Artery Research)
Source: Artery Research - May 23, 2017 Category: Cardiology Authors: T.T. van Sloten Tags: Review Source Type: research
Post-processing reproducibility of the structural characteristics of the common carotid artery in a Flemish population
The objective of the study was to evaluate the intra- and inter-reader reproducibility of the measurements following a standardised protocol. (Source: Artery Research)
Source: Artery Research - May 16, 2017 Category: Cardiology Authors: Ljupcho Efremov, Wen-Yi Yang, Lotte Jacobs, Lutgarde Thijs, Tatiana Kuznetsova, Harry A.J. Struijker-Boudier, Jan A. Staessen Source Type: research
Change of bilateral difference in radial artery pulse morphology with one-side arm movement
This study aimed to quantify the bilateral difference in radial artery pulse morphology with one-side arm movement. Twenty-four healthy subjects were recruited. Radial artery pulses were synchronously recorded from both arms, with one arm (left or right) at five different positions (90 °, 45°, 0°, −45° and −90°) and the other arm at horizontal level (0°) as reference. Two types of indices of arterial pulse morphology were derived from the normalized arterial pulse signals: the waveform width corresponding to the 50%, 60% and 70% pulse amplitude (W50, W60, W70) and the to tal area of normalized pulse waveform (Apu...
Source: Artery Research - May 12, 2017 Category: Cardiology Authors: Xinge Jiang, Shoushui Wei, Dingchang Zheng, Feifei Liu, Shouqin Zhang, Zhimin Zhang, Chengyu Liu Source Type: research
Towards a consensus on the understanding and analysis of the pulse waveform: Results from the 2016 Workshop on Arterial Hemodynamics: Past, present and future
This paper aims to summarize and map contemporary views on some contentious aspects of arterial hemodynamics that have remained unresolved despite years of research. These were discussed during a workshop entitled Arterial hemodynamics: past, present and future held in London on June 14 and 15, 2016. To do this we formulated a list of potential consensus statements informed by discussion at the meeting in London and quantified the degree of agreement and invited comments from the participants of the workshop. (Source: Artery Research)
Source: Artery Research - April 27, 2017 Category: Cardiology Authors: Patrick Segers, Michael F. O'Rourke, Kim Parker, Nico Westerhof, Alun Hughes, Participants of the 2016 Workshop on Arterial Hemodynamics: Past, present and future Tags: Review Source Type: research
The reservoir-wave model
This paper is based on a talk given at the Arterial Hemodynamics: Past, Present and Future symposium in June 2016. Like the talk it is divided into three different but related parts. Part 1 describes the calculation of reservoir and excess pressure from clinical pressure waveforms measured at 5 different aortic sites in 40 patients. The main results are that the reservoir pressure waveform propagates down the aorta and is effectively constant from the aortic root to the aortic bifurcation. Part 2 describes a low-frequency asymptotic analysis of the input impedance of an arterial tree. (Source: Artery Research)
Source: Artery Research - April 26, 2017 Category: Cardiology Authors: Kim H. Parker Source Type: research
Should a statin be given to all hypertensive patients?
Statins have become an essential treatment for primary and secondary prevention of cardiovascular risk. This has been firmly established for patients with a relatively high risk for cardiovascular complications. Recent studies, in particular the HOPE trial, has extended this observation to patients with intermediate cardiovascular risk, including hypertensive patients. On the other hand, statin use has been associated with side effects in a small percentage of patients. The decision to add a statin to the drug treatment of a hypertensive patient should be based on an assessment of the individual's potential risk reduction ...
Source: Artery Research - April 21, 2017 Category: Cardiology Authors: Harry Struijker-Boudier Tags: Review Source Type: research
Rare chest pain causes by right bronchial artery
A 42-year-old with diabetes mellitus presented with chest pain. During his initial presentation, he suddenly felt dyspnea with back pain. Physical examination was unremarkable and resting electrocardiography was normal. Serial myocardial enzyme examinations were normal. Therefore, computed tomography of chest, abdomen was performed evaluate the possibility of aortic dissection. The images showed enhancement of right bronchial artery arising from descending aorta (Fig. 1: axial view, Figs. 2 and 3: sequence images of coronal view). (Source: Artery Research)
Source: Artery Research - April 21, 2017 Category: Cardiology Authors: Ching Chih Liu, Yuan Pin Hsu Tags: Case presentation Source Type: research
Application of arterial hemodynamics to clinical practice: A testament to medical science in London
A strong heritage of science has been handed down in Britain from outstanding individuals, promoted and encouraged by strong scientific and medical societies. Application to clinical practice in recent years has been slow but can be expected to advance in the present and future age of new sensors, fast computing and clinical problems awaiting explanation. Agreement on terminology and physical mechanisms needs be fostered. (Source: Artery Research)
Source: Artery Research - April 18, 2017 Category: Cardiology Authors: Michael F. O'Rourke, Audrey Adji, Wilmer W. Nichols, Charalambos Vlachopoulos, Elazer R. Edelman Tags: Discussion Source Type: research
Wave potential: A unified model of arterial waves, reservoir phenomena and their interaction
Models of haemodynamics play a central role in current research directed to understanding and addressing cardiovascular disease. Although conventional windkessel and wave models are very useful, they are incompatible due to conflicting assumptions and neither comprehensively explain the basis and interdependencies of pressure/flow waves, mean pressure and reservoir filling/discharge phenomena. The hybrid reservoir-wave model was proposed to address this gap, but is not widely accepted due to theoretical inconsistencies and negative results from validation studies. (Source: Artery Research)
Source: Artery Research - April 14, 2017 Category: Cardiology Authors: Jonathan P. Mynard, Joseph J. Smolich Tags: Review Source Type: research
Practical solutions for hypertensive patients with dyslipidemia
Arterial hypertension and dyslipidemia often coexist and constitute major risk factors of ischemic heart disease. Aggressive treatment of both comorbidities is of paramount importance to decrease global risk. Low adherence is a determinant of poor risk factor control and increases adverse cardiovascular outcomes. Regarding treatment of hypertension, combination therapy is superior in achieving target BP values compared to up-titrating monotherapy and it is recommended in hypertension guidelines. (Source: Artery Research)
Source: Artery Research - April 5, 2017 Category: Cardiology Authors: Charalambos Vlachopoulos, Nikolaos Ioakeimidis Tags: Review Source Type: research
Waves and Windkessels reviewed
Pressure and flow are travelling waves and are reflected at many locations. The forward and reflected waves, obtained by wave separation, are compound waves. This compounded character of the reflected wave explains why its magnitude decreases with increased peripheral resistance, why it appears to run forward rather than backward, and why its return time relates poorly with aortic wave speed. A single tube (aorta) with distal reflection is therefore an incorrect arterial model. Wave Intensity Analysis (WIA) uses time derivatives of pressure and flow, augmenting rapid changes and incorrectly suggesting a ‘wave free period...
Source: Artery Research - March 31, 2017 Category: Cardiology Authors: Nicolaas Westerhof, Berend E. Westerhof Tags: Review Source Type: research
Gut microbiota and vascular biomarkers in patients without clinical cardiovascular diseases
The aim of this research was to study the association between the gut microbiota composition and arterial wall properties. The study included 92 participants, men and women aged 25 –76 years old without clinical manifestation of chronic diseases but with the possible presence of cardiovascular risk factors. Carbohydrate metabolism examination, duplex scanning of the carotid arteries with the measurement of the intima-media thickness (IMT), the carotid-femoral pulse wave velo city (PWV) measurement, and 16S rRNA (V3V4 regions) sequencing of the gut microbiota were performed in all participants. (Source: Artery Research)
Source: Artery Research - March 20, 2017 Category: Cardiology Authors: Daria Kashtanova, Olga Tkacheva, Anna Popenko, Lilit Egshatyan, Alexander Tyakht, Dmitry Alexeev, Yulia Kotovskaya, Ekaterina Plokhova, Sergey Boytsov Source Type: research
Endothelin 1 and endothelial dysfunction in children with idiopathic nephrotic syndrome
Endothelial dysfunction is the initial step for atherogenesis. Children with idiopathic nephrotic syndrome are at risk of endothelial dysfunction due to altered cholesterol metabolism which can lead to early atherosclerosis. (Source: Artery Research)
Source: Artery Research - March 16, 2017 Category: Cardiology Authors: Venkatesh Arumugam, Abhijeet Saha, Manpreet Kaur, Kanika Kapoor, Nimisha Arora, Trayambak Basak, Shantanu Sengupta, Ajay Bhatt, Nitin Bharadwaj, Vineeta V. Batra, Ashish Datt Upadhyay Source Type: research
