Mean Difference, Standardized Mean Difference (SMD), and Their Use in Meta-Analysis: As Simple as It Gets.
This article presents and explains the different terms and concepts with the help of simple examples. PMID: 32965803 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 25, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Depression and Suicidal Behavior in Young Adult Men and Women With ADHD: Evidence From Claims Data.
This study used commercial claims data to examine the effects of ADHD and sex on the prevalence of depression, suicidal ideation, and suicide attempts in a sample of young adult men and women (aged 18-25 years) with and without attention-deficit/hyperactivity disorder (ADHD). Patterns of treatment use for these conditions was also explored. METHODS: Young adults with ADHD (162,263 women and 225,705 men) having at least 2 claims with the International Classification of Diseases, Ninth Revision (ICD-9), code for ADHD and a sex- and age-matched group of young adults without an ICD-9 code for ADHD (162,263 women and 225,70...
Source: Journal of Clinical Psychiatry - September 25, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Antisuicidal Effect of Esketamine Should Be Further Investigated.
Authors: Olié E, Nobile B, Courtet P PMID: 32965805 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 25, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Suicide and Happiness: The Association Between Two Potential Sustainable Development Goal Indicators for Mental Health.
Authors: Hsu CY, Chang SS, Gunnell D PMID: 32936541 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 18, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Simple Suggestion: Make Follow-Up Appointments for All Patients After Discharge, Especially Those With Co-Occurring Addictions.
Authors: Ostacher MJ PMID: 32936542 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 18, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Effect of Scheduling a Post-Discharge Outpatient Mental Health Appointment on the Likelihood of Successful Transition From Hospital to Community-Based Care.
CONCLUSIONS: Scheduling an outpatient mental health appointment is an effective and low-resource discharge planning practice that should be an important target for inpatient psychiatric clinical quality measurement and improvement. PMID: 32936543 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 18, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Epidemiology and Pathophysiology of Dementia-Related Psychosis.
This report examines the frequency, symptoms, and pathophysiology of DRP and communication about psychotic symptoms with patients with dementia (if possible) and their care partners. PMID: 32936544 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 18, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Pharmacotherapy for Treatment-Resistant Obsessive-Compulsive Disorder.
Authors: Kayser RR PMID: 32926602 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 16, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Acute Effects of Parent Stimulant Medication Versus Behavioral Parent Training on Mothers' ADHD, Parenting Behavior, and At-Risk Children.
This report describes a pilot early intervention study directly comparing parent lisdexamfetamine dimesylate (LDX) to behavioral parent training (BPT) in families in which the mother had currently untreated ADHD and the young child displayed ADHD symptoms. METHODS: Mothers with ADHD (N = 35) of 4- to 8-year-old stimulant-naive children (N = 35) were randomly assigned to an 8-week trial of LDX (starting at 20 mg/d and titrated to a maximum of 70 mg/d) or BPT. Outcomes included multi-method, multi-informant measures of (1) maternal ADHD symptoms (Conners' Adult ADHD Rating Scales) and impairment (Clinical Global Impressi...
Source: Journal of Clinical Psychiatry - September 16, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Efficacy and Safety of Dasotraline in Adults With Binge-Eating Disorder: A Randomized, Placebo-Controlled, Flexible-Dose Clinical Trial.
Authors: McElroy SL, Hudson JI, Grilo CM, Guerdjikova AI, Deng L, Koblan KS, Goldman R, Navia B, Hopkins S, Loebel A Abstract OBJECTIVE: Binge-eating disorder (BED) is the most prevalent eating disorder; however, few evidence-based treatments are available. The aim of this study was to evaluate the efficacy and safety of dasotraline, a novel dopamine and norepinephrine reuptake inhibitor, in adults with BED. METHODS: Patients with a DSM-5 diagnosis of BED (intent-to-treat sample, N = 315) were randomized to 12 weeks of double-blind treatment with once-daily, flexible doses (4, 6, or 8 mg/d) of dasotraline or pl...
Source: Journal of Clinical Psychiatry - September 16, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Treating Excessive Daytime Sleepiness in Patients With Narcolepsy.
Authors: Roth T Abstract ​​ Excessive daytime sleepiness (EDS) is a hallmark symptom of narcolepsy. The second major symptom, cataplexy, is present only in a subgroup of patients with narcolepsy. Fortunately, existing pharmacologic interventions are effective in reducing EDS for many patients, but elimination of EDS for most patients has not been achieved. Some interventions also show efficacy in cataplexy. Nonpharmacologic strategies should also be discussed with patients to provide optimal narcolepsy management. Clinicians must monitor EDS during ongoing treatment so that residual symptoms can be addressed wi...
Source: Journal of Clinical Psychiatry - September 16, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Trends in Psychiatric Emergency Department Visits Due to Suicidal Ideation and Suicide Attempts During the COVID-19 Pandemic in Madrid, Spain.
Authors: Hernández-Calle D, Martínez-Alés G, Mediavilla R, Aguirre P, Rodríguez-Vega B, Bravo-Ortiz MF PMID: 32898342 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 9, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Omega-3 Fatty Acid Supplementation for Perinatal Depression: A Meta-Analysis.
Authors: Mocking RJT, Steijn K, Roos C, Assies J, Bergink V, Ruhé HG, Schene AH Abstract OBJECTIVE: Several randomized controlled trials (RCTs) investigated omega-3 polyunsaturated fatty acids (PUFAs) (ie, fish oil) in perinatal depression, but their efficacy remains unclear. We performed a meta-analysis of RCTs on omega-3 PUFAs for perinatal depression, comparing a priori defined subgroups: pregnant women vs postpartum women and prevention vs treatment of perinatal depression. METHODS: We searched Web of Science, Embase, PsycINFO, and the Cochrane Library, combining omega-3 PUFAs and perinatal depressio...
Source: Journal of Clinical Psychiatry - September 9, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Omega-3 Fatty Acid Supplementation for Perinatal Depression and Other Subpopulations?
Authors: Sarris J, Freeman MP PMID: 32898344 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 9, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

To Be Continued? Long-Term Treatment Effects of Antidepressant Drug Classes and Individual Antidepressants on the Risk of Developing Dementia: A German Case-Control Study.
CONCLUSIONS: Long-term treatment with tricyclic antidepressants, Hypericum perforatum, or escitalopram may be associated with reduced incidence of dementia. If antidepressant therapy is well tolerated, continuation-even if depressive symptoms have resolved-may be considered even beyond the purpose of relapse prevention. Future combined analyses of multinational registries and long-term clinical trials are needed to substantiate these findings. PMID: 32857931 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 30, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Why Do Some Older Adults Treated With Antidepressants Progress to Dementia?
Authors: Brown EE, Rajji TK, Mulsant BH PMID: 32857932 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 30, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Escitalopram in Adolescents With Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled Study.
This study evaluated the efficacy and tolerability of escitalopram in adolescents with GAD (DSM-IV-TR) and the impact of variants in HTR2A and serotonin transporter (SLC6A4) genes and cytochrome P450 2C19 (CYP2C19) phenotypes on response as well as CYP2C19 phenotype on escitalopram pharmacokinetics from February 2015 through November 2018. METHODS: Patients were treated with escitalopram (forced titration to 15 mg/d, then flexible titration to 20 mg/d) (n = 26, mean ± SD age: 14.8 ± 1.7 years) or placebo (n = 25, mean ± SD age: 14.9 ± 1.6 years) for 8 weeks. Outcomes were the change in score...
Source: Journal of Clinical Psychiatry - August 30, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Association of Lithium Use and a Higher Serum Concentration of Lithium With the Risk of Declining Renal Function in Older Adults: A Population-Based Cohort Study.
CONCLUSION: In older adults, lithium use is associated with a statistically significant increased risk of renal decline compared to valproate use, although the decline is less than previously reported. Further studies should confirm whether this effect is primarily in patients with higher serum lithium concentrations. PMID: 32841553 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 27, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Beyond 52-Week Long-Term Safety: Long-Term Outcomes of Aripiprazole Lauroxil for Patients With Schizophrenia Continuing in an Extension Study.
Authors: Lauriello J, Claxton A, Du Y, Weiden PJ Abstract OBJECTIVE: To describe the long-term safety, tolerability, and symptom trajectory with the long-acting injectable antipsychotic aripiprazole lauroxil (AL) in patients with DSM-5-diagnosed schizophrenia followed for up to 180 weeks (3.5 years). METHODS: Long-term safety of 2 fixed doses of AL (441 or 882 mg every 4 weeks) was assessed during up to 180 weeks (3.5 years) of continuous AL exposure using data from 2 sequential long-term safety studies. Safety metrics included adverse events (AEs), AEs leading to study discontinuations, physical examinations, ...
Source: Journal of Clinical Psychiatry - August 27, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Individualized, High-Dose Baclofen for Reduction in Alcohol Intake in Persons With High Levels of Consumption.
Authors: Andrade C Abstract Alcohol use disorders (AUD) are common and impairing. Many pharmacologic interventions have been approved for AUD; baclofen is one among these. More than a dozen randomized controlled trials (RCTs) have examined the safety and efficacy of baclofen in AUD; these RCTs have been pooled in 4 recent meta-analyses, each with different study selection criteria, different objectives, different methods, and different results. The general impression from these meta-analyses is that the benefits with baclofen are unimpressive in patients with AUD. With the background that individualized, rather tha...
Source: Journal of Clinical Psychiatry - August 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Clinical Trials With Suicidal Individuals Can Be Conducted Safely.
Authors: Ballard ED, Park LT, Pao M, Zarate CA PMID: 32757505 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

COVID-19, Mental Health, and Suicide Risk Among Health Care Workers: Looking Beyond the Crisis.
Authors: Reger MA, Piccirillo ML, Buchman-Schmitt JM PMID: 32757506 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

What to Expect When Switching to a Second Antidepressant Medication Following an Ineffective Initial SSRI: A Report From the Randomized Clinical STAR*D Study.
CONCLUSIONS: Following nonefficacy with an initial SSRI, only about 20% remit and more than half achieve no meaningful benefit with a second-step switch to another monoaminergic antidepressant. A 12-week trial duration seems necessary to capture as many second-step switch responders as possible. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00021528. PMID: 32780949 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Psychiatric Side Effects of Chloroquine.
Authors: Gressier F, Verstuyft C, Becquemont L, Falissard B, Corruble E PMID: 32726000 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 31, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Increasing Emergency Department Visits for Mental Health Conditions in the United States.
This study examined trends and correlates of ED visits for mental health conditions from 2007 to 2016, with attention to changes in ED use after 2014. METHODS: Nationally representative samples of ED visits in the United States were assessed using a repeated cross-sectional analysis of National Hospital Ambulatory Medical Care Survey data. This study used diagnoses associated with each ED visit to identify changes in proportions in mental health diagnostic categories (psychiatric diagnoses only, substance use-related diagnoses only, or both, based on ICD-9-CM or ICD-10-CM criteria). These trends were further examined b...
Source: Journal of Clinical Psychiatry - July 31, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dissociation in Pharmacokinetic Attenuation Between Central Dopamine D2 Receptor Occupancy and Peripheral Blood Concentration of Antipsychotics: A Systematic Review.
CONCLUSIONS: The findings indicate pharmacokinetic attenuation of antipsychotics was generally slower at the central versus the peripheral level and pose a critical challenge to the current dosing strategy that primarily relies on peripheral pharmacokinetics of antipsychotics. PMID: 32726002 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 31, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Procognitive Effects of Antidepressants and Other Therapeutic Agents in Major Depressive Disorder: A Systematic Review.
CONCLUSIONS: Present-day antidepressants and other agents have demonstrated procognitive effects in MDD, but the findings between various agents are mixed. Further research looking at objective measures of cognitive performance would be helpful to obtain more definitive results regarding the efficacy of therapeutics for cognitive impairment in MDD. PMID: 32726521 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 31, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Methylphenidate and the Risk of New-Onset Seizures.
Authors: Andrade C Abstract Attention-deficit/hyperactivity disorder (ADHD) is usually treated with stimulant drugs such as methylphenidate (MPH). ADHD is associated with an increased risk of seizures and, in this context, concerns have been expressed that stimulant drugs, including MPH, may increase the seizure risk. However, 4 large observational studies have found that ADHD drugs in general and stimulant drugs in particular are not associated with increased seizure risk and may, in fact, be associated with a reduced risk of seizures; these studies were largely conducted in children and adolescents, including tho...
Source: Journal of Clinical Psychiatry - July 31, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Screening for Excessive Daytime Sleepiness and Diagnosing Narcolepsy.
Authors: Winkelman JW Abstract Sleep disorders such as narcolepsy can cause excessive daytime sleepiness (EDS). However, the diagnosis of narcolepsy is often delayed by years in both children and adults, reducing their quality of life. Clinicians can improve the recognition of EDS and diagnosis of sleep disorders using screening tools such as the Epworth Sleepiness Scale, collecting sleep histories, and using sleep laboratory tests. By following up with patients who present with EDS and continuing to assess until a cause is found, clinicians can lessen the time to diagnosis and the negative impact of narcolepsy by ...
Source: Journal of Clinical Psychiatry - July 31, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Randomized, Double-Blind, Placebo-Controlled Trial of the mGlu2/3 Negative Allosteric Modulator Decoglurant in Partially Refractory Major Depressive Disorder.
CONCLUSIONS: Decoglurant was well tolerated overall but did not exert any antidepressant or procognitive effects. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01457677. PMID: 32663909 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 16, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Impact of Comorbid PTSD on Outcome of Repetitive Transcranial Magnetic Stimulation (TMS) for Veterans With Depression.
CONCLUSIONS: Comorbid PTSD did not impact the outcome of TMS for depression in this sample of veterans. Future studies should include formal ratings of PTSD to determine if the severity of PTSD affects the outcome. PMID: 32659874 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 14, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Characterization of the Quality of Electroconvulsive Therapy Among Older Medicare Beneficiaries.
Authors: Rhee TG, Olfson M, Sint K, Wilkinson ST Abstract BACKGROUND: Electroconvulsive therapy (ECT) is an important therapy for treatment-resistant depression and is especially effective for elderly individuals with depression. This is the first US nationally representative description of ECT in the elderly. METHODS: Using 2014-2015 Medicare claims data, we compared elderly individuals with major depressive disorder (using ICD-9 and ICD-10 codes) who received ECT with those who did not on demographic and clinical measures. We characterized treatment patterns by setting and the proportion of individuals receiv...
Source: Journal of Clinical Psychiatry - July 14, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Using Long-acting Injectable Antipsychotics to Enhance the Potential for Recovery in Schizophrenia.
This report highlights information provided by experts on the reasons for, impact of, and means to reduce relapse in patients with schizophrenia; on patient-centered and patient-reported assessment; on the benefits and risks of medication options, including long-acting injectable (LAI) antipsychotics; and on psychosocial interventions that may improve adherence and help prevent relapse in individuals living with schizophrenia. Modifiable risk factors for poor outcomes in patients with schizophrenia include longer duration of untreated illness, comorbid substance abuse, early nonresponse to an antipsychotic, and the number ...
Source: Journal of Clinical Psychiatry - July 3, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Does Nitrous Oxide Help Veterans With Posttraumatic Stress Disorder? A Case Series.
Authors: Varias A, van Roessel P, Parsiani M, Filippou-Frye M, Neylan TC, Nagele P, Yesavage J, Clark JD, Rodriguez CI PMID: 32609959 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 3, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The SNAP 101 Double-Blind, Placebo/Active-Controlled, Safety, Pharmacokinetic, and Pharmacodynamic Study of INP105 (Nasal Olanzapine) in Healthy Adults.
CONCLUSIONS: INP105 has rapid absorption and pharmacodynamic effects and may represent an effective, convenient, noninvasive, and well-tolerated alternative for treating acutely agitated patients by self- or caregiver administration in the home, community, or hospital environments. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT03624322. PMID: 32609960 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 3, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Women Are at Greater Risk of OCD Than Men: A Meta-Analytic Review of OCD Prevalence Worldwide.
CONCLUSIONS: Women are typically at greater risk of experiencing OCD in their lifetime than men. PMID: 32603559 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 1, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Impact of Concurrent Posttraumatic Stress Disorder on Outcomes of Antipsychotic Augmentation for Major Depressive Disorder With a Prior Failed Treatment: VAST-D Randomized Clinical Trial.
CONCLUSIONS: Although PTSD was associated with poorer overall outcomes, the presence of concurrent PTSD among Veterans in this trial did not affect the comparative effectiveness of medications on response, remission, or relapse after initial remission. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01421342. PMID: 32603560 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 1, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Preventive Cognitive Therapy With Antidepressant Discontinuation During Pregnancy: Results From a Randomized Controlled Trial.
Authors: Molenaar NM, Brouwer ME, Burger H, Kamperman AM, Bergink V, Hoogendijk WJG, Williams AD, Bockting CLH, Lambregtse-van den Berg MP PMID: 32603561 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 1, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Casting Light From the Shadows: Coping and Defenses Amidst a Pandemic.
Authors: McDowell MJ, Salvi JD PMID: 32558400 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Risk of Relapse of Depression During Pregnancy After Discontinuation of Antidepressants: A Systematic Review and Meta-Analysis.
CONCLUSIONS: Women with severe or recurrent depression should be informed about the increased risk of relapse following antidepressant discontinuation, and those who discontinue antidepressants should be monitored for relapse. PMID: 32558401 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Effects of Open-Label, Adjunctive Ganaxolone on Persistent Depression Despite Adequate Antidepressant Treatment in Postmenopausal Women: A Pilot Study.
Authors: Dichtel LE, Nyer M, Dording C, Fisher LB, Cusin C, Shapero BG, Pedrelli P, Kimball AS, Rao EM, Mischoulon D, Fava M, Miller KK Abstract OBJECTIVE: The neuroactive steroid metabolite of progesterone, allopregnanolone, is a positive allosteric modulator of γ-aminobutyric acid-A (GABAA) receptors and a putative treatment for mood disorders. This pilot study was performed to determine whether an oral allopregnanolone analog (ganaxolone) may be effective adjunctive therapy for persistent depression despite adequate antidepressant treatment in postmenopausal women. METHOD: Ten postmenopausal women (mea...
Source: Journal of Clinical Psychiatry - June 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Identifying Profiles of Patients With Bipolar I Disorder Who Would Benefit From Maintenance Therapy With a Long-Acting Injectable Antipsychotic.
Authors: Tohen M, Goldberg JF, Hassoun Y, Sureddi S Abstract People with bipolar I disorder experience an illness course marked by potentially disastrous manic episodes, disabling depressive episodes, and functional impairment. A frequent obstacle to wellness in these individuals is nonadherence to treatment. Long-acting injectable (LAI) antipsychotics have the potential to address nonadherence and thereby increase patients' chances at sustained recovery and normal psychosocial functioning. LAI formulations of 2 second-generation antipsychotics-aripiprazole monohydrate and risperidone-have received approval from th...
Source: Journal of Clinical Psychiatry - June 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Depression as a Factor in Nonadherence in Schizophrenia.
Authors: Hirakawa H, Ishii N PMID: 32558404 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Drs Kane and Correll Reply.
Authors: Kane JM, Correll CU PMID: 32558405 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Beyond the Respiratory System: A Case Report Highlighting the Impact of COVID-19 in Mental Illness and Its Physical Consequences.
Authors: Morillo-González J, Hernández-Huerta D, Guillama-Henríquez A, Correa-Palacio A, Pereira-Nogueira P PMID: 32558406 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Symptom Dimension of Interest-Activity Indicates Need for Aripiprazole Augmentation of Escitalopram in Major Depressive Disorder: A CAN-BIND-1 Report.
Authors: Uher R, Frey BN, Quilty LC, Rotzinger S, Blier P, Foster JA, Müller DJ, Ravindran AV, Soares CN, Turecki G, Parikh SV, Milev R, MacQueen G, Lam RW, Kennedy SH, CAN-BIND Investigator Team Abstract OBJECTIVE: Differential predictors of response to alternative treatment options are needed to improve the outcomes in major depressive disorder. The symptom dimension comprising loss of interest and reduced activity has been reported as a predictor of poor outcome of treatment with antidepressants. We hypothesized that augmentation with partial dopamine agonist aripiprazole will be effective for individuals w...
Source: Journal of Clinical Psychiatry - June 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Major Congenital Malformation Risk After First Trimester Gestational Exposure to Oral or Intravenous Ondansetron.
Authors: Andrade C Abstract Ondansetron is a 5-HT₃ receptor antagonist that has been approved for the prevention of nausea and vomiting associated with cancer chemotherapy, radiotherapy, and surgery. Ondansetron has also been studied in the treatment of many neuropsychiatric and medical conditions. The drug is commonly used off-label to treat nausea and vomiting of pregnancy (NVP) and hyperemesis gravidarum (HG). Ondansetron crosses the placental barrier, and concerns have been expressed that using ondansetron for NVP/HG during the first trimester of pregnancy may increase the risk of major congenital malformatio...
Source: Journal of Clinical Psychiatry - June 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Association of Benzodiazepines and Antidepressants With 180-Day Mortality Among Patients With Dementia Receiving Antipsychotic Pharmacotherapy: A Nationwide Registry-Based Study.
CONCLUSIONS: The diverse impact of concomitant use of benzodiazepines and antidepressants on mortality may be due to a direct drug-related effect. Alternatively, the findings could reflect differential mortality associated with different indications for therapy. Although the results cannot prove causality, and there may be residual confounding, clinicians should be cautious when considering the combination of antipsychotics and benzodiazepines in patients with dementia. PMID: 32526104 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Are (Some) Antipsychotics Depressogenic in Bipolar Disorder?
Authors: Goldberg JF PMID: 32526105 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Predictors of Depressive Switch in Patients With Bipolar I Disorder Who Initiated or Changed Pharmacologic Treatment for Mania or Mixed-Mania: A Prospective Observational Study.
Authors: Maccariello G, Barbuti M, Vannucchi G, De Bartolomeis A, Fagiolini A, Maina G, Perugi G Abstract OBJECTIVE: To evaluate the prevalence and the predictors of depressive switch in patients with bipolar I disorder (BD-I) requiring the initiation or change (but not a dose change) of treatment with oral antipsychotics or mood stabilizers for mania or mixed-mania. METHODS: This was a 3-month, prospective, noninterventional study conducted in 34 Italian psychiatric centers from April 2012 to April 2013. The study sample comprised 234 patients aged 18 years or older presenting with a manic episode according to...
Source: Journal of Clinical Psychiatry - June 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research