Predicting Worsening Suicidal Ideation With Clinical Features and Peripheral Expression of Messenger RNA and MicroRNA During Antidepressant Treatment.
Authors: Belzeaux R, Fiori LM, Lopez JP, Boucekine M, Boyer L, Blier P, Farzan F, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Milev R, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Uher R, Foster JA, Kennedy SH, Turecki G Abstract OBJECTIVE: To investigate how the combination of clinical and molecular biomarkers can predict worsening of suicidal ideation during antidepressant treatment. METHODS: Samples were obtained from 237 patients with major depressive disorder (DSM-IV criteria) treated with either duloxetine or placebo in an 8-week randomized controlled trial. Data were collected between 2007 an...
Source: Journal of Clinical Psychiatry - May 16, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A 9-Year Follow-Up of Attention-Deficit/Hyperactivity Disorder in a Population Sample.
CONCLUSIONS: We replicated predictors of the persistence of ADHD found in prior studies and provide new data about predictors of new ADHD onsets in the population. Our findings about subthreshold ADHD support a dimensional conceptualization of the disorder, highlighting the potential clinical utility of a subthreshold diagnostic category. This study also contributes to the ongoing debate regarding adult-onset ADHD. PMID: 31087826 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 16, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Medical Marijuana: What Physicians Need to Know.
Authors: Radhakrishnan R, Ranganathan M, D'Souza DC PMID: 31087827 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 16, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Coaggregation of Major Psychiatric Disorders in First-Degree Relatives of Individuals With Attention-Deficit/Hyperactivity Disorder: A Nationwide Population-Based Study.
DISCUSSION: These results show that ADHD coaggregated with other major psychiatric disorders, specifically schizophrenia, bipolar disorder, major depressive disorder, and ASD, within families. The results suggest that public health officials and psychiatrists should closely monitor and follow the mental health of FDRs of ADHD-diagnosed individuals, such as parents and siblings of children with ADHD. PMID: 31090279 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 16, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Activating and Sedating Properties of Medications Used for the Treatment of Major Depressive Disorder and Their Effect on Patient Functioning.
Authors: Citrome LL, McIntyre RS, Manning JS, McIntosh D Abstract Although the sedative and extrapyramidal side effects associated with first-generation antipsychotics are well known, some second-generation antipsychotics are also associated with substantial sedation and activation effects. In this Academic Highlights article, 4 experts on depression from the fields of psychiatry and primary care take a closer look at activation and sedation effects of atypical antipsychotics in patients with MDD. They examine the likelihood of each agent to cause these effects; the impact of these effects on patient functioning, q...
Source: Journal of Clinical Psychiatry - May 16, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Sleep-Associated Adverse Events During Methylphenidate Treatment of Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis.
Authors: Faraone SV, Po MD, Komolova M, Cortese S Abstract OBJECTIVE: Sleep disturbances are a feature of attention-deficit/hyperactivity disorder (ADHD) and an adverse event (AE) of methylphenidate treatment. The authors sought to clarify methylphenidate-associated sleep problems and how studies are affected by confounding factors. DATA SOURCES: Published studies in English collected via online databases and unpublished data from www.clinicaltrials.gov and US Food and Drug Administration websites. Sources were searched from inception to August 2017. STUDY SELECTION: Included were blinded placebo-controlled...
Source: Journal of Clinical Psychiatry - May 16, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Differential Diagnosis of Major Depressive Disorder Versus Bipolar Disorder: Current Status and Best Clinical Practices.
Authors: McIntyre RS, Zimmerman M, Goldberg JF, First MB Abstract The purpose of this article is to provide psychiatrists and other health care professionals who treat patients with major depressive disorder and bipolar disorder a set of best practices, tools, and other methods to improve their ability to make a more accurate diagnosis between major depressive disorder and bipolar disorder and to reach this diagnosis sooner, given a particular set of patient-related circumstances and comorbidities.​. PMID: 31091027 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 16, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The 5-Year Course of Medication Treatment in Childhood Anxiety Disorders.
CONCLUSIONS: Guidelines implying discontinuation of medication after symptom remission and a limited period of stability do not accurately reflect clinical practice. PMID: 31091028 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 16, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Closing the Research-To-Practice Gap in Digital Psychiatry: The Need to Integrate Implementation Science.
Authors: Lipschitz J, Hogan TP, Bauer MS, Mohr DC PMID: 31091029 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 16, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Risk of Dementia Among Individuals With Psoriasis: A Nationwide Population-Based Cohort Study in Taiwan.
CONCLUSIONS: Individuals with psoriasis have a significantly higher incidence of dementia, particularly the nonvascular type. Systemic therapy might be protective in preventing dementia in patients with psoriasis. PMID: 31091030 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 16, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Incidence Rates of Treated Mental Disorders in Childhood and Adolescence in a Complete Nationwide Birth Cohort.
CONCLUSIONS: These findings provide the most comprehensive estimates of the development, incidence rates, and contributing risk factors of registered mental disorders for the entire period of childhood and adolescence that have been calculated so far. PMID: 31050232 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 5, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Patients With Early-Phase Schizophrenia Will Accept Treatment With Sustained-Release Medication (Long-Acting Injectable Antipsychotics): Results From the Recruitment Phase of the PRELAPSE Trial.
CONCLUSIONS: Large numbers of early-phase patients with schizophrenia were willing to participate in an LAI antipsychotic trial and by inference in non-study LAI antipsychotic treatment. LAI antipsychotic-focused staff training has the potential to substantially enhance the use of LAI antipsychotics. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02360319. PMID: 31050233 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 5, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Oral Ketamine for Depression: A Systematic Review.
The objective of the current systematic review, in accordance with PRISMA, is to determine the efficacy, safety, tolerability, and dose range of oral ketamine for bipolar and unipolar depression. DATA SOURCES: The MEDLINE/PubMed, EMBASE, and Google Scholar databases were systematically searched for relevant articles, written in English, published prior to July 2018 using relevant keywords for all variants of ketamine, oral, and depression. STUDY SELECTION: All clinical studies assessing oral ketamine for bipolar or unipolar depression were included. A total of 13 published articles were identified, of which 2 were ...
Source: Journal of Clinical Psychiatry - April 19, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Lipid Disturbances in Adolescents Treated With Second-Generation Antipsychotics: Clinical Determinants of Plasma Lipid Worsening and New-Onset Hypercholesterolemia.
Authors: Delacrétaz A, Vandenberghe F, Glatard A, Dubath C, Levier A, Gholam-Rezaee M, Holzer L, Ambresin AE, Conus P, Eap CB Abstract OBJECTIVE: Lipid disturbances following treatment with second-generation antipsychotics (SGAs) represent a major health concern. A previous study determined that early changes of plasma lipid levels ≥ 5% during the first month of treatment with SGAs predicts further lipid worsening and development of dyslipidemia. This current study aimed to determine the proportion of adolescents with early lipid changes ≥ 5% and who develop dyslipidemia during SGA treatment. METHO...
Source: Journal of Clinical Psychiatry - April 19, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Oral Ketamine for Depression, 2: Practical Considerations.
This article reviews strategies for dosing with oral ketamine, dose discovery procedures, rates of dosing during a session, the frequency of dosing sessions and the duration of treatment, treatment in the clinic vs domiciliary treatment, adverse effects and risks, and safety issues. Finally, this article provides a detailed account of practices and experiences with oral ketamine so that readers may know what to expect when the treatment is orally administered. Whereas oral ketamine appears to be a safe and effective treatment and could make ketamine an accessible and affordable intervention in less privileged medical facil...
Source: Journal of Clinical Psychiatry - April 19, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Genetics Guideline Is Excellent, but the Pharmacogenetics Section Is Weak.
Authors: de Leon J PMID: 30997962 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - April 19, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Nurnberger and Colleagues Reply.
Authors: Nurnberger JI, Austin J, Berrettini WH, Besterman AD, DeLisi LE, Grice DE, Kennedy JL, Moreno-De-Luca D, Potash JB, Ross DA, Schulze TG, Zai G PMID: 30997963 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - April 19, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Negative Schema and Rumination as Mediators of the Relationship Between Childhood Trauma and Recent Suicidal Ideation in Patients With Early Psychosis.
CONCLUSIONS: These findings highlight the importance of performing careful evaluations of childhood trauma and suicidality and of developing effective strategies to reduce mediating factors that may be amenable to psychosocial approaches. PMID: 30946541 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - April 6, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Updated Meta-Analysis of Epidemiologic Studies of Pediatric Bipolar Disorder.
Authors: Van Meter A, Moreira ALR, Youngstrom E Abstract OBJECTIVE: Research on pediatric bipolar disorder (PBD) has grown substantially in the past 7 years; updating a 2011 meta-analysis of PBD prevalence could improve understanding of factors that influence prevalence. DATA SOURCES: A literature review of papers published in English was updated in 2018 using PubMed and PsycINFO. Search terms included pediatric, child, "bipolar disorder," bipolar, mania, prevalence, epidemiology, community, adolescent, and youth. STUDY SELECTION: Inclusion criteria were (1) youth epidemiologic sample, (2) number ...
Source: Journal of Clinical Psychiatry - April 6, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Oral Ketamine for Depression, 1: Pharmacologic Considerations and Clinical Evidence.
Authors: Andrade C Abstract Clinical evidence is accumulating to support the use of ketamine as a powerful, quick-acting intervention for depression. Ketamine has been administered by oral, sublingual, transmucosal, intravenous, intramuscular, subcutaneous, intranasal, and even rectal routes. Whereas intravenous ketamine is the best studied approach, common sense dictates that oral ketamine is the most practical. The bioavailability of oral ketamine and interindividual variations thereof have been poorly studied; possibly only 20%-25% of an oral dose reaches the bloodstream. This is not necessarily a limitation bec...
Source: Journal of Clinical Psychiatry - April 6, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Correlates of Opioid Abstinence in a 42-Month Posttreatment Naturalistic Follow-Up Study of Prescription Opioid Dependence.
CONCLUSIONS: While opioid agonist treatment was most strongly associated with opioid abstinence among patients with prescription opioid dependence over time, mutual-help group attendance was independently associated with opioid abstinence. Clinicians should consider recommending both of these interventions to patients with opioid use disorder. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00316277​. PMID: 30920187 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 30, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Start Predicts the Finish: Factors Associated With Antidepressant Nonadherence Among Older Veterans During the Acute and Maintenance Treatment Phases.
This study compared factors associated with antidepressant nonadherence during the acute (ie, during the first 4 months) and maintenance (ie, during 12 months) treatment phase among older veterans with depression. METHODS: In this prospective, observational study of 278 older veterans with depression (Patient Health Questionnaire-9 score ≥ 5), patients had been given a new antidepressant prescription between 2008 and 2011. Participants completed initial and follow-up interviews at 4 and 12 months. Medication adherence was assessed by the Brief Medication Questionnaire. A generalized estimating equation was used to d...
Source: Journal of Clinical Psychiatry - March 30, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Managing Transitions in Care and Adherence to Improve Outcomes in Schizophrenia.
Authors: Lauriello J, Perkins DO Abstract With effective, continuous care, individuals with schizophrenia can experience long periods of wellness, but, unfortunately, many patients end up repeating a cycle of treatment interruptions leading to relapses. In this webcast, Dr John Lauriello and Dr Diana Perkins explore all dimensions of this topic, from the many causes of treatment interruptions to the steps clinicians can take to prevent them. Interviews with actual patients and caregivers are also presented. PMID: 30920189 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 30, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Treatment-Resistant Schizophrenia: A Brief Overview of Treatment Options.
Authors: Faden J PMID: 30900848 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 24, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Computer-Assisted Cognitive-Behavior Therapy for Depression: A Systematic Review and Meta-Analysis.
CONCLUSIONS: CCBT with a modest amount of support from a clinician or other helping person was found to be efficacious with relatively large mean effect sizes on measures of depressive symptoms. Self-guided CCBT for depression was considerably less effective. Future research should focus on enhancing the implementation of CCBT, including evaluating the amount and type of support needed for effective delivery, methods to improve engagement with computer-assisted therapies, and ways to improve treatment outcome in primary care settings. PMID: 30900849 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 24, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Disclosure of Alzheimer's Disease and Dementia: Patient- and Care Partner-Centric Decision-Making and Communication.
Authors: Goldfarb D, Sheard S, Shaughnessy L, Atri A Abstract Disclosing the diagnosis of cognitive impairment or dementia due to Alzheimer's disease (AD) and Related Dementias (ADRD) can be one of the most challenging aspects of dementia care for clinicians. However difficult the diagnosis is to give or receive, evidence and evidence-based consensus support that disclosing a timely AD/ADRD diagnosis, accompanied by psychoeducation and care planning, is beneficial to patient-care partner dyads. Diagnosis, provided as early as possible, increases the likelihood for patients to be involved in decision-making and plan...
Source: Journal of Clinical Psychiatry - March 24, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Drug Prescription and Delirium in Older Inpatients: Results From the Nationwide Multicenter Italian Delirium Day 2015-2016.
CONCLUSIONS: Polypharmacy is significantly associated with delirium only in surgical units, raising the issue of the relevance of medication review in different clinical settings. Specific drug classes are associated with delirium depending on the clinical setting and dementia diagnosis, suggesting the need to further explore this relationship. PMID: 30901165 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 24, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Wang and Colleagues Reply.
Authors: Wang LJ, Lee SY, Shyu YC PMID: 30901166 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 24, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Database Studies and the Pitfall of Imputing Complex Clinical Causality.
Authors: Poulton AS PMID: 30901167 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 24, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Sexually Transmitted Infection Among Adolescents and Young Adults With Bipolar Disorder: A Nationwide Longitudinal Study.
CONCLUSIONS: Adolescents and young adults with bipolar disorder exhibited an increased risk of subsequent STI during the follow-up period compared with those without bipolar disorder. Comorbidity of substance and alcohol use disorders further increased this risk. Long-term use of bipolar disorder medications (mood stabilizers and atypical antipsychotics) may reduce this risk. PMID: 30901168 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 24, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Using Screening Tools and Diagnosing Bipolar Disorder in Pediatric Patients.
Authors: Singh MK Abstract At least half of the cases of bipolar disorder begin in childhood or adolescence. How do you decide whether a young patient's symptoms indicate bipolar disorder? Read this CME Brief Report to learn about reliable tools and methods to identify bipolar disorder in pediatric patients. PMID: 30865786 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 14, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Current and Emerging Treatments to Address Unmet Needs in MDD.
Authors: Thase ME Abstract Most people who experience a depressive episode are greatly impaired by it. No one-size-fits-all therapy is available, and most patients require multiple treatment steps. Check out this CME activity to learn about current and emerging strategies for managing MDD. PMID: 30865787 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 14, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Getting to Remission: Differentiating Residual Symptoms From Treatment Side Effects in Major Depressive Disorder.
Authors: McIntyre RS Abstract Despite the availability of effective treatments for MDD, many individuals have difficulty achieving remission. Residual symptoms can be difficult to differentiate from treatment side effects. Through 2 comic-based case presentations, this CME activity depicts common clinical scenarios and provides evidence-based strategies for effectively identifying and managing residual symptoms of MDD. PMID: 30865788 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 14, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Treating Bipolar Disorder in Pediatric Patients and Educating Patients and Parents.
Authors: DelBello MP Abstract Despite the availability of effective treatments for MDD, many individuals have difficulty achieving remission. Residual symptoms can be difficult to differentiate from treatment side effects. Through 2 comic-based case presentations, this CME activity depicts common clinical scenarios and provides evidence-based strategies for effectively identifying and managing residual symptoms of MDD. PMID: 30865789 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 14, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Predictors of Long-Term and High-Dose Use of Zolpidem in Veterans.
Authors: Kim HM, Gerlach LB, Van T, Yosef M, Conroy DA, Zivin K Abstract OBJECTIVE: Prescriptions for sedative hypnotics are routinely initiated and renewed to treat insomnia, despite evidence supporting nonpharmacologic treatments as comparable and more favorable over time. We used national Veterans Health Administration data to assess patient characteristics associated with high-dose and long-term zolpidem use. METHOD: The study included outpatients with new zolpidem prescriptions (January 1, 2013, to June 3, 2014). We defined high-dose use as use of doses above those recommended in the 2013 FDA safety warnin...
Source: Journal of Clinical Psychiatry - March 7, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report.
Authors: Kennedy SH, Lam RW, Rotzinger S, Milev RV, Blier P, Downar J, Evans KR, Farzan F, Foster JA, Frey BN, Giacobbe P, Hall GB, Harkness KL, Hassel S, Ismail Z, Leri F, McInerney S, MacQueen GM, Minuzzi L, Müller DJ, Parikh SV, Placenza FM, Quilty LC, Ravindran AV, Sassi RB, Soares CN, Strother SC, Turecki G, Vaccarino AL, Vila-Rodriguez F, Yu J, Uher R, CAN-BIND Investigator Team Abstract OBJECTIVE: To report the symptomatic and functional outcomes in patients with major depressive disorder (MDD) during a 2-phase treatment trial and to estimate the value of early improvement after 2 weeks in predicting cl...
Source: Journal of Clinical Psychiatry - March 7, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Clinical Guidance on the Identification and Management of Treatment-Resistant Schizophrenia.
This report summarizes the consensus from a roundtable that focused on defining and identifying TRS, pathways to treatment resistance, current treatments, unmet needs, and disease burden. Nine clinical experts in schizophrenia and TRS participated in a closed meeting on June 23, 2017, sponsored by Lundbeck, at which published literature in key areas of TRS research was reviewed. The findings from published studies were synthesized by experts in each area and presented to the group for review and discussion. It was agreed that inadequate response to 2 different antipsychotics, each taken with adequate dose and duration, is ...
Source: Journal of Clinical Psychiatry - March 7, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Exposure to Second-Generation Antipsychotics and Risk of Type 2 Diabetes Mellitus in Adolescents and Young Adults: A Nationwide Study in Taiwan.
Authors: Tu TH, Huang KL, Bai YM, Hsu JW, Su TP, Li CT, Tsai SJ, Lin WC, Chen TJ, Chen MH Abstract BACKGROUND: The association between second-generation antipsychotics (SGAs) and type 2 diabetes mellitus (T2DM) has been well investigated in adults. However, T2DM risk has been less examined among adolescents with SGA exposure, and the risk remains uncertain in this population. METHODS: A total of 91,185 adolescents and young adults within the Taiwan National Health Insurance system who were exposed to SGAs were enrolled into this study between 2000 and 2011.The patients were divided into 4 subgroups on the basis...
Source: Journal of Clinical Psychiatry - March 7, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Real-World Effectiveness Study Comparing a Priority Appointment, an Enhanced Contact Intervention, and a Psychotherapeutic Program Following Attempted Suicide.
CONCLUSIONS: In a naturalistic clinical setting, patients exposed to individual psychotherapy or an enhanced contact intervention had a similar, lower relapse risk than the single priority appointment group. PMID: 30817098 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 4, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Clinical Characteristics and Treatment Response to Lisdexamfetamine Dimesylate Versus Placebo in Adults With Binge Eating Disorder: Analysis by Gender and Age.
Authors: Kornstein SG, Bliss C, Kando J, Madhoo M Abstract OBJECTIVE: To describe clinical characteristics and lisdexamfetamine dimesylate (LDX) treatment effects, based on gender and age, in adults diagnosed with moderate to severe binge eating disorder (BED). METHODS: Adults diagnosed with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision-defined BED of moderate to severe severity were randomized to 12 weeks of dose-optimized LDX (50 or 70 mg) or placebo in 2 studies (conducted from November 26, 2012, to September 25, 2013 [study 1] and from November 26, 2012, to September 2...
Source: Journal of Clinical Psychiatry - March 4, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Enhancing the Treatment of Patients With Schizophrenia Through Continuous Care.
Authors: Lauriello J, Perkins DO Abstract Schizophrenia is a chronic disorder that can be effectively controlled but will likely require lifelong treatment. Unfortunately, most patients experience numerous relapses, ongoing symptoms, and impairment, often because of treatment interruptions. Continuous treatment is imperative to prevent relapse and the potentially devastating consequences that can follow a return of psychotic symptoms. Clinicians must better monitor a common cause of relapse, nonadherence, and offer strategies to improve adherence. Strategies can target the patient, the environment, or treatment. On...
Source: Journal of Clinical Psychiatry - February 21, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Sultans of Swing: A Reappraisal of the Intertwined Association Between Affective Lability and Mood Reactivity in a Post Hoc Analysis of the BRIDGE-II-MIX Study.
Authors: Verdolini N, Menculini G, Perugi G, Murru A, Samalin L, Angst J, Azorin JM, Bowden CL, Mosolov S, Young AH, Barbuti M, Popovic D, Vieta E, Pacchiarotti I, BRIDGE-II-MIX Study Group Abstract OBJECTIVE: This post hoc analysis of the BRIDGE-II-MIX study is aimed at evaluating affective lability (AL) as a possible clinical feature of mixed depression and assessing the relationship with atypical depressive features, particularly mood reactivity (MR). METHODS: In the BRIDGE-II-MIX multicenter, cross-sectional study, 2,811 individuals suffering from a major depressive episode (MDE; DSM-IV-TR criteria), in the...
Source: Journal of Clinical Psychiatry - February 21, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Efficacy and Tolerability of Pharmacotherapy for Pediatric Anxiety Disorders: A Network Meta-Analysis.
CONCLUSIONS: Although multiple medications reduce anxiety in children and adolescents, treatment response, tolerability, and treatment-emergent suicidality differ among these medications and medication classes. Determining whether efficacy and tolerability differences represent true differences (or reflect differences in trial design) requires additional head-to-head medication trials and-to exclude the impact of missing treatment interventions-requires trials of medications that successfully treat anxiety in adults but that have not been evaluated in youth. PMID: 30753760 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - February 14, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Natural and Synthetic Cannabinoids for Agitation and Aggression in Alzheimer's Disease: A Meta-Analysis.
Authors: Ruthirakuhan M, Lanctôt KL, Vieira D, Herrmann N Abstract OBJECTIVE: This meta-analysis investigated the efficacy of cannabinoids on agitation and aggression in patients with Alzheimer's disease (AD). DATA SOURCES: Electronic records up to August 2018 were searched from MEDLINE, EMBASE, and PsycINFO. Search terms included Alzheimer's disease, agitation, aggression, and cannabinoids. STUDY SELECTION: Double-blind, placebo-controlled studies investigating the effect of cannabinoids on agitation in patients with AD were included. Of the 1,336 records returned, 123 were reviewed and 6 (N = 251 pa...
Source: Journal of Clinical Psychiatry - February 14, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Antidepressants, Mood Stabilizers, Antipsychotics, and the Risk of Cataract.
Authors: Andrade C Abstract Cataract is a common disease of the eye, and depression is common in patients with cataract. This raises the possibility that depression and the drugs used to treat depression may be risk factors for cataract. In a recent systematic review and meta-analysis of 7 case-control studies with a pooled sample of 447,672 cases and 1,510,391 controls, antidepressant drugs were associated with a very small but statistically significant increase in the risk of cataract; the odds ratios for different classes of antidepressants were in the 1.12-1.19 range. None of the 7 studies in the meta-analysis ...
Source: Journal of Clinical Psychiatry - February 14, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Psychiatric Disorders and Crime in the US Population: Results From the National Epidemiologic Survey on Alcohol and Related Conditions Wave III.
CONCLUSIONS: Community adults with substance use disorders, comorbid substance use and mental health disorders, and increasing multimorbidity are most at risk of crime and justice involvement, highlighting the importance of community-based addiction treatment. PMID: 30758921 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - February 14, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Suicide Immediately After Discharge From Psychiatric Inpatient Care: A Cohort Study of Nearly 2.9 Million Discharges.
CONCLUSIONS: A distinct elevation of the risk of suicide was seen in all diagnostic groups if a recent self-harm event had occurred, particularly among patients with psychotic disorders. Overall, the immediate risk of suicide after discharge was high regardless of recent suicidal behavior. The findings in this study have relevance for clinical decisions about immediate after-care and treatment in connection with discharge from psychiatric inpatient care. PMID: 30758922 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - February 14, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Celebrating JCP's 80th Year.
Authors: Shelton JS PMID: 30695287 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 31, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Prevalence of and Risk Factors for Extrapyramidal Side Effects of Antipsychotics: Results From the National FACE-SZ Cohort.
Authors: Misdrahi D, Tessier A, Daubigney A, Meissner WG, Schurhoff F, Boyer L, Godin O, Bulzacka E, Aouizerate B, Andrianarisoa M, Berna F, Capdevielle D, Chereau-Boudet I, D'Amato T, Dubertret C, Dubreucq J, Faget-Agius C, Lançon C, Mallet J, Passerieux C, Rey R, Schandrin A, Urbach M, Vidailhet P, Llorca PM, Fond G, FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) Group Abstract BACKGROUND: Extrapyramidal side effects (EPS) have been identified as a complication of antipsychotic treatment. Previous meta-analyses have investigated EPS prevalence and risk factors in randomized clinical ...
Source: Journal of Clinical Psychiatry - January 31, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

JCP at 80: Continuing a Tradition of Excellence.
Authors: Freeman MP PMID: 30695289 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 31, 2019 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research