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Reconsidering Insomnia as a Disorder Rather Than Just a Symptom in Psychiatric Practice.
Authors: Benca RM, Buysse DJ Abstract Insomnia is a common feature of many psychiatric disorders but can also be a comorbid disorder, often contributing to poor outcomes and treatment failure. For some patients who do respond to psychiatric treatment, their insomnia persists after their mood symptoms have remitted, indicating that their insomnia needs to be a separate focus of treatment. In this CME Academic Highlights, Drs Ruth Benca and Daniel Buysse discuss how to effectively evaluate patients with psychiatric disorders for comorbid insomnia, as well as how to safely and effectively implement both behavioral and...
Source: Journal of Clinical Psychiatry - January 27, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Risk of Major Congenital Malformations Associated With the Use of Methylphenidate or Amphetamines in Pregnancy.
Authors: Andrade C Abstract The use of prescription psychostimulants during pregnancy has been increasing in recent years. One large and 3 small studies have recently examined the risk of major congenital malformations following the use of methylphenidate and amphetamines during the first trimester of pregnancy. The broad findings of these studies are that first trimester gestational exposure to methylphenidate or amphetamines is associated with an increased risk of major congenital malformations but the associations are no longer statistically significant after adjusting analyses for confounding variables; that fi...
Source: Journal of Clinical Psychiatry - January 27, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Validity of the Maudsley Staging Method in Predicting Treatment-Resistant Depression Outcome Using the Netherlands Study of Depression and Anxiety.
Authors: van Belkum SM, Geugies HH, Lysen TS, Cleare AJ, Peeters FPML, Penninx BWJH, Schoevers RA, Ruhe EG Abstract OBJECTIVE: We investigated if the degree of treatment resistance of depression, as measured by the Maudsley Staging Method (MSM), is predictive of a worse depression outcome by using a large naturalistic cohort of depressed patients. METHODS: 643 subjects from the general population, primary care, and secondary care who suffered from current depressive disorder were included from the Netherlands Study of Depression and Anxiety baseline assessment. The diagnostic criterion was major depressive diso...
Source: Journal of Clinical Psychiatry - January 27, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Facial Emotion Recognition Performance Differentiates Between Behavioral Variant Frontotemporal Dementia and Major Depressive Disorder.
Authors: Chiu I, Piguet O, Diehl-Schmid J, Riedl L, Beck J, Leyhe T, Holsboer-Trachsler E, Kressig RW, Berres M, Monsch AU, Sollberger M Abstract OBJECTIVE: Misdiagnosis of early behavioral variant frontotemporal dementia (bvFTD) with major depressive disorder (MDD) is not uncommon due to overlapping symptoms. The aim of this study was to improve the discrimination between these disorders using a novel facial emotion perception task. METHOD: In this prospective cohort study (July 2013-March 2016), we compared 25 patients meeting Rascovsky diagnostic criteria for bvFTD, 20 patients meeting DSM-IV criteria for MD...
Source: Journal of Clinical Psychiatry - January 25, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Thirty Great Years.
Authors: Shelton JS PMID: 29345862 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

All Good Things ….
All Good Things…. J Clin Psychiatry. 2017 Nov/Dec;78(9):1330 Authors: Gelenberg AJ PMID: 29345863 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Naltrexone and Disulfiram Treatment Response in Veterans With Alcohol Dependence and Co-Occurring Problem-Gambling Features.
Authors: Grant JE, Potenza MN, Kraus SW, Petrakis IL Abstract BACKGROUND: Disordered gambling behavior frequently co-occurs with alcohol dependence and other psychiatric conditions. Using data from a previously published trial, we conducted secondary analyses to examine the influence of problem-gambling features on treatment outcome for alcohol dependence or co-occurring psychopathology assessed via DSM-IV criteria. METHODS: Two hundred fifty-four patients with alcohol dependence and co-occurring psychiatric disorders were treated for 12 weeks in an outpatient medication study conducted at 3 Veterans Administra...
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Few Who Served Deserved to Be Cared For.
Authors: Shale JH PMID: 29345865 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management.
Authors: Culpepper L, Lam RW, McIntyre RS Abstract ​​ Cognitive impairment is a common, often persistent, symptom of major depressive disorder (MDD) that is disproportionately represented in patients who have not returned to full psychosocial functioning. The ultimate goal of treatment in depression is full functional recovery, and assessing patients for cognitive impairment and selecting treatments that address cognitive dysfunction should lead to improved functional outcomes. Unfortunately, many clinicians use screening and assessment tools that are not suited for measuring cognitive impairment in patients wi...
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Findings of Interest.
Authors: Wagner KD PMID: 29345867 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Gap Between the Randomized Controlled Trial-Based Evidence and Real-World Practice in Switching Strategies of Major Depressive Disorder.
Authors: Chen K, Mei Q PMID: 29345868 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Drs Bschor and Baethge Reply.
Authors: Bschor T, Baethge C PMID: 29345869 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Antidepressant Response and Dissociative Effects After Ketamine Treatment: Two Sides of the Same Coin?
Authors: Bartoli F, Clerici M, Carrà G PMID: 29345870 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Andrade Replies.
Authors: Andrade C PMID: 29345871 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Cognitive Planning Neural Correlates in a Pediatric Monozygotic Twin Pair Discordant for Obsessive-Compulsive Disorder: Exploring Potential Application in Precision Medicine.
Authors: Jaspers-Fayer F, Negreiros J, Lin SY, Belschner L, Stewart SE PMID: 29345872 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Patient Education in Psychopharmacology and the Risk of Nocebo-Related Treatment Inefficacy and Harm.
This article provides suggestions on the subject for clinical practice as well as research. Nonspecific factors in psychopharmacology are important and should not be neglected. PMID: 29345873 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Epidemiology and Prevention of Tardive Dyskinesia.
Authors: Correll CU Abstract What risk factors suggest that patients are more likely to develop tardive dyskinesia (TD)? Can TD symptoms be prevented? Read this CME activity to learn about the prevalence, epidemiology, and prevention of these abnormal movements from an expert. PMID: 29345874 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Available Tools for Assessing Cognitive Impairment in Major Depressive Disorder.
Authors: McIntyre RS Abstract You know that measuring cognition in your patients with depression is important. But cognitive assessment instruments can be difficult to access, expensive, time consuming, and not available in an electronic format. Read this CME activity to learn about a new free tool. PMID: 29345875 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Assessing Patients for Tardive Dyskinesia.
Authors: Kane JM Abstract Do you regularly screen for tardive dyskinesia in at-risk patients? Explore this CME activity by a well-known expert for information on rating scales for screening, available diagnostic criteria, assessment tips, and monitoring recommendations. PMID: 29345876 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Comparing Treatments for Tardive Dyskinesia.
Authors: Citrome LL Abstract Many treatment interventions for tardive dyskinesia have been studied, but some have better evidence than others. Read this CME activity to get an expert's perspectives on the evidence for older and newer treatments so that you can minimize abnormal movements in your patients. PMID: 29345877 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Impact of Cognitive Impairment on Functioning in Patients With Depression.
Authors: Lam RW Abstract Reassessing a patient's diagnosis if he or she does not respond adequately to initial antidepressant pharmacotherapy is imperative. In this CME activity, evaluate the case of Melissa, a 32-year-old architect with a potential case of treatment-resistant depression, and decide on appropriate treatment strategies. PMID: 29345878 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Improving Long-Term Outcomes in Patients With Schizophrenia: What Is the Evidence for Long-Acting Injectable Antipsychotics?
Authors: Perkins DO Abstract Do you consider long-acting injectable (LAI) antipsychotics when selecting among treatments for schizophrenia? Take part in this CME activity to review the evidence for LAIs vs oral medications and to learn which patients may benefit most from this treatment option. Plus, discover the pharmacokinetic properties of LAIs and barriers to their use. PMID: 29345879 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Strategies for Managing Patients With Depression Who Are Experiencing Cognitive Impairment.
Authors: Culpepper L Abstract Pronounced deficits in executive function are found in up to one-third of patients with MDD, and this impairment can keep patients from achieving full functional recovery. In this CME activity, review the evidence regarding the effectiveness of available interventions to improve cognitive dysfunction in patients with MDD. PMID: 29345880 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 19, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Prospective Associations Between Infant Sleep at 12 Months and Autism Spectrum Disorder Screening Scores at 24 Months in a Community-Based Birth Cohort.
Authors: Nguyen AKD, Murphy LE, Kocak M, Tylavsky FA, Pagani LS Abstract BACKGROUND: Sleep problems have been associated with autism spectrum disorder (ASD) symptoms and diagnosis. However, past research has studied the simultaneous association of sleep problems with precursor ASD symptoms. Using data from a birth cohort, we estimate prospective associations between infant sleep characteristics at 12 months and later ASD screening scores at 24 months. METHODS: We obtained data from children (N = 1,096) and their mothers as participants in the Conditions Affecting Neurocognitive Development and Learning in Early...
Source: Journal of Clinical Psychiatry - January 14, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Taking on the Role of Editor in Chief.
Authors: Freeman MP PMID: 29325235 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 14, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Treatment With a Ghrelin Agonist in Outpatient Women With Anorexia Nervosa: A Randomized Clinical Trial.
CONCLUSIONS: Treatment with a ghrelin agonist in women with anorexia nervosa significantly decreases gastric emptying time, leads to a trend in weight gain after only 4 weeks, and is well-tolerated. Further study is necessary to determine the long-term safety and efficacy of a ghrelin agonist in the treatment of anorexia nervosa. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01642550. PMID: 29325236 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 14, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Psychometrics of the Self-Report Concise Associated Symptoms Tracking Scale (CAST-SR): Results From the STRIDE (CTN-0037) Study.
CONCLUSIONS: These results demonstrate the factor structure, reliability, and validity of the CAST-SR in a novel population of only individuals with stimulant use disorders receiving both exercise/health education interventions and antidepressant medication. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01141608. PMID: 29325238 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 14, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Insomnia and Psychopathological Features Associated With Restless Legs Syndrome in Chinese Adolescents.
This study examined sleep duration, insomnia, and psychopathological profile associated with RLS in a large community sample of adolescents. Methods: Participants included 11,831 adolescents from 3 counties of Shandong, China. Mean age of the participants was 15.0 (SD = 1.5) years, and 51% were boys. In November and December 2015, participants completed a structured questionnaire to assess sleep duration, sleep problems, behavioral/emotional problems, and hopelessness. RLS was assessed by the 2003 National Institutes of Health (NIH) Restless Legs Syndrome Diagnosis and Epidemiology Workshop criteria. RESULTS: Of th...
Source: Journal of Clinical Psychiatry - January 14, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Advanced Topics in Major Depressive Disorder: Practical Strategies to Improve Remission.
Authors: Jain R Abstract Health Spectrum is a dynamic platform designed for healthcare professionals who want more from their educational experience. Enter our "virtual office," where 2 interactive patient cases allow you to explore practical considerations for patients with recurrent depression despite adequate trials of antidepressants. PMID: 29325240 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 14, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Association Between Sleep Apnea and Suicidal Thought and Behavior: An Analysis of National Survey Data.
CONCLUSIONS: Suicidal ideation and suicide planning were more likely to be endorsed by respondents with sleep apnea compared to those without after accounting for key covariates. Diagnosis of sleep apnea may represent an early opportunity for providers to discuss suicide and mental health with their patients. PMID: 29286590 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 30, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Repeated Low-Grade Infections Predict Antidepressant-Resistant Depression: A Nationwide Population-Based Cohort Study.
Authors: Jeng JS, Li CT, Chen MH, Lin WC, Bai YM, Tsai SJ, Su TP, Chang WH, Sung YJ Abstract BACKGROUND: The relationship between severe inflammation and clinical depression in the context of major medical illnesses has been addressed, but the relationship between inflammation caused by mild infections and clinical depression is unclear. We aimed to examine whether a history of repeated low-grade infections (RLGI) in medically healthy subjects (MHS) could increase their vulnerability to major depressive disorder (MDD) (ICD-9-CM) and whether RLGI could be associated with higher resistance to antidepressants in those...
Source: Journal of Clinical Psychiatry - December 30, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Circadian Rhythm Sleep-Wake Disorders Predict Shorter Time to Relapse of Mood Episodes in Euthymic Patients With Bipolar Disorder: A Prospective 48-Week Study.
Authors: Takaesu Y, Inoue Y, Ono K, Murakoshi A, Futenma K, Komada Y, Inoue T Abstract OBJECTIVE: Circadian rhythm dysfunction has been considered to be common in bipolar disorder (BD) and plays an important role in mood dysregulation in this disorder. However, no study has investigated whether circadian rhythm dysfunction would affect the clinical course of BD. The aim of this study was to test the hypothesis that circadian rhythm dysfunction could be a predictor of relapse in euthymic BD patients. METHODS: One hundred four euthymic outpatients with BD diagnosed according to the criteria of the Diagnostic and ...
Source: Journal of Clinical Psychiatry - December 30, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Circadian Rhythm and the Prediction of Relapse in Bipolar Disorder.
Authors: Gonzalez R, Tohen M PMID: 29286594 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 30, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Galantamine and Computerized Cognitive Behavioral Therapy for Cocaine Dependence: A Randomized Clinical Trial.
CONCLUSIONS: Findings suggest benefits of galantamine and computerized CBT for reducing cocaine use in this sample. Although galantamine did not improve measures of cognitive function in this sample, multiple measures of cognitive function were associated with cocaine use outcomes, underlining the significance of cognitive function in cocaine treatment outcomes. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00809835. PMID: 29286595 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 30, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Herpes Zoster and Dementia: A Nationwide Population-Based Cohort Study.
CONCLUSIONS: Herpes zoster was associated with an increased risk of dementia, independent of potential confounding factors. Antiviral treatment might be protective in preventing dementia in patients with herpes zoster. PMID: 29244265 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 16, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Patients With Alcohol Use Disorder Co-Occurring With Depression and Anxiety Symptoms: Diagnostic and Treatment Initiation Recommendations.
Authors: Hassan AN PMID: 29244266 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 16, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Refining Prediction in Treatment-Resistant Depression: Results of Machine Learning Analyses in the TRD III Sample.
CONCLUSIONS: With the application of the machine learning algorithm RF, an efficient prediction model with an accuracy of 75.0% for forecasting treatment outcome could be generated, thus surpassing the predictive capabilities of clinical evaluation. We also supply a simplified algorithm of 15 easily collected clinical and sociodemographic predictors that can be obtained within approximately 10 minutes, which reached an accuracy of 70.6%. Thus, we are confident that our model will be validated within other samples to advance an accurate prediction model fit for clinical usage in TRD. PMID: 29228516 [PubMed - as supplied...
Source: Journal of Clinical Psychiatry - December 13, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Cost-Effectiveness of Internet-Based Cognitive-Behavioral Treatment for Bulimia Nervosa: Results of a Randomized Controlled Trial.
CONCLUSIONS: Third-party payor cost-effectiveness of Internet-based CBT-BN is comparable with that of an accepted standard. Internet-based dissemination of CBT-BN may be a viable alternative for patients geographically distant from specialist eating disorder services who have an unmet need for treatment. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00877786​. PMID: 29228517 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 13, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Childhood Trauma Is Associated With Poorer Cognitive Performance in Older Adults.
Authors: Petkus AJ, Lenze EJ, Butters MA, Twamley EW, Wetherell JL Abstract OBJECTIVE: Childhood trauma is common and associated with both worse cognitive performance and disruption to the hypothalamic-pituitary-adrenal axis in younger adults. The extent to which these associations persist into older adulthood remains unknown. The aim of this study was to investigate self-reported childhood trauma in relation to cognitive performance, and the extent to which cortisol explained this association, in 2 independent samples of older adults. METHODS: In this cross-sectional study, participants in the discovery sample...
Source: Journal of Clinical Psychiatry - December 13, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Utilizing the DSM-5 Anxious Distress Specifier to Develop Treatment Strategies for Patients With Major Depressive Disorder.
Authors: PMID: 29188904 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Review and Meta-Analysis of Epidemiologic Studies of Adult Bipolar Disorder.
CONCLUSIONS: The overall prevalence rate is consistent with historical estimates, but rates vary significantly across studies. Differences in methodology contribute to the perception that rates of BD have increased over time. Rates varied markedly by geographic region, even after controlling for all other predictors. Research using consistent definitions and methods may expose specific factors that confer risk for BD. PMID: 29188905 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Is Psychiatric Epidemiology Still Counting?
Authors: Weissman MM PMID: 29188906 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Prescribing Patterns in a Psychiatrically Referred Sample of Youth With Autism Spectrum Disorder.
CONCLUSIONS: Psychiatrically referred youth with ASD suffer from multiple highly impairing psychiatric disorders that require combination pharmacotherapy. These findings highlight the need for further research to guide clinical decision-making and treatment. PMID: 29188907 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Anticholinergic Burden and Cognition in Older Patients With Schizophrenia.
CONCLUSIONS: High anticholinergic burden contributes to specific cognitive deficits in older individuals with schizophrenia that resemble those commonly observed early in the course of Alzheimer's dementia. The ACB is a potentially useful screening tool that can help identify patients at risk of developing anticholinergic-related cognitive impairment. PMID: 29188908 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Reducing Anticholinergic Medication Burden in Patients With Psychotic or Bipolar Disorders.
CONCLUSIONS: In this interdisciplinary, collaborative QI project, patients whose anticholinergic burden was reduced experienced a significant improvement in side effects, memory, and quality of life. PMID: 29178683 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Supervised Exercise Intervention for Youth at Risk for Psychosis: An Open-Label Pilot Study.
CONCLUSIONS: The results of this study suggest that exercise interventions are feasible in a UHR sample and may promote improvement in clinical, social, and cognitive domains as well as changes to brain function in regions impacted by the development of psychosis. These findings set the stage for an ongoing phase 2 randomized controlled trial. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02155699. PMID: 29178684 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Clinical and Genetic Predictors of Delayed Remission After Multiple Levels of Antidepressant Treatment: Toward Early Identification of Depressed Individuals for Advanced Care Options.
Authors: Falola MI, Limdi N, Shelton RC Abstract OBJECTIVE: To identify clinical and genetic characteristics that can be used to recognize depressed patients who are likely to respond quickly versus those who will have a more delayed response following multiple treatment trials. METHODS: The data used were obtained from the National Institute of Mental Health-sponsored Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, which was conducted between July 2001 and September 2006. Of the 4,041 treatment-naive participants in the original study, 1,953 with DNA samples were included. Major depressi...
Source: Journal of Clinical Psychiatry - November 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Memantine as an Augmentation Treatment for Schizophrenia: Limitations of Meta-Analysis for Evidence-Based Evaluation of Research.
Authors: Andrade C Abstract The action of memantine on N-methyl-D-aspartate (NMDA) glutamatergic receptors and the other pharmacodynamic actions of this drug suggest that it may benefit patients with schizophrenia. Many randomized controlled trials (RCTs) have examined this possibility. These RCTs have been meta-analyzed by at least 2 groups of authors. In one meta-analysis (8 RCTs, pooled N = 448), memantine (20 mg/d for 6-12 weeks) augmentation of antipsychotic drug therapy was found to attenuate the severity of negative symptoms and improve cognitive functioning; in both regards, the effect was large. Memantine ...
Source: Journal of Clinical Psychiatry - November 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Effects of Valbenazine in Participants with Tardive Dyskinesia: Results of the 1-Year KINECT 3 Extension Study.
CONCLUSIONS: The long-term safety and tolerability of valbenazine were generally favorable, and maintenance of treatment effect was apparent with both doses during this long-term study. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02274558. PMID: 29141124 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 16, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Elevated Proinflammatory Markers in 22q11.2 Deletion Syndrome Are Associated With Psychosis and Cognitive Deficits.
Authors: Mekori-Domachevsky E, Taler M, Shoenfeld Y, Gurevich M, Sonis P, Weisman O, Weizman A, Gothelf D Abstract OBJECTIVE: 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder whose phenotype includes high rates of a schizophrenia-like psychotic disorder and immune system abnormalities. Thus, 22q11.2DS is an ideal model for studying the relationship between psychosis and inflammation. The aim of the present study was to identify inflammatory markers that may play a role in the pathophysiologic pathways associated with psychosis and cognitive deficits in 22q11.2DS. METHODS: Forty-nine individuals ...
Source: Journal of Clinical Psychiatry - November 16, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research