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The Effects of Valbenazine in Participants with Tardive Dyskinesia: Results of the 1-Year KINECT 3 Extension Study.
CONCLUSIONS: The long-term safety and tolerability of valbenazine were generally favorable, and maintenance of treatment effect was apparent with both doses during this long-term study. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02274558. PMID: 29141124 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 16, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Elevated Proinflammatory Markers in 22q11.2 Deletion Syndrome Are Associated With Psychosis and Cognitive Deficits.
Authors: Mekori-Domachevsky E, Taler M, Shoenfeld Y, Gurevich M, Sonis P, Weisman O, Weizman A, Gothelf D Abstract OBJECTIVE: 22q11.2 deletion syndrome (22q11.2DS) is a neurogenetic disorder whose phenotype includes high rates of a schizophrenia-like psychotic disorder and immune system abnormalities. Thus, 22q11.2DS is an ideal model for studying the relationship between psychosis and inflammation. The aim of the present study was to identify inflammatory markers that may play a role in the pathophysiologic pathways associated with psychosis and cognitive deficits in 22q11.2DS. METHODS: Forty-nine individuals ...
Source: Journal of Clinical Psychiatry - November 16, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Association Between Comorbid Autism Spectrum Disorders and Antipsychotic Treatment Failure in Early-Onset Psychosis: A Historical Cohort Study Using Electronic Health Records.
Authors: Downs JM, Lechler S, Dean H, Sears N, Patel R, Shetty H, Simonoff E, Hotopf M, Ford TJ, Diaz-Caneja CM, Arango C, MacCabe JH, Hayes RD, Pina-Camacho L Abstract OBJECTIVE: In a sample of children and adolescents with first-episode psychosis, we investigated whether multiple treatment failure (MTF, defined as the initiation of a third trial of novel antipsychotic due to nonadherence, adverse effects, or insufficient response) was associated with comorbid autism spectrum disorders. METHODS: Data were from the electronic health records of 638 children (51% male) aged from 10 to 17 years with first-episode ...
Source: Journal of Clinical Psychiatry - November 12, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Management of New Onset Psychosis in the Postpartum Period.
Authors: Tinkelman A, Hill EA, Deligiannidis KM PMID: 29125722 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 12, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Diagnostic Challenge of the Late-Onset Frontal Lobe Syndrome: Clinical Predictors for Primary Psychiatric Disorders Versus Behavioral Variant Frontotemporal Dementia.
Authors: Vijverberg EGB, Gossink F, Krudop W, Sikkes S, Kerssens C, Prins N, Stek M, Scheltens P, Pijnenburg Y, Dols A Abstract OBJECTIVE: Primary psychiatric disorders (PsD) can present with symptomatology identical to that of behavioral variant frontotemporal dementia (bvFTD). To date, clinical guidelines do not provide a solution for this diagnostic challenge. The aim of our study was to prospectively determine which demographic, clinical, neuropsychological, neuroimaging, and cerebrospinal fluid biomarkers are important in distinguishing PsD from bvFTD. METHODS: Patients with late-onset behavioral disturban...
Source: Journal of Clinical Psychiatry - November 5, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Treating Pediatric Anxiety: Initial Use of SSRIs and Other Antianxiety Prescription Medications.
CONCLUSIONS: SSRIs are the most commonly used first-line medication for pediatric anxiety disorders, with about half of SSRI initiators continuing treatment for 6 months. Still, a third began therapy on a non-SSRI medication, for which there is limited evidence of effectiveness for pediatric anxiety, and a notable proportion of children initiated with 2 antianxiety medication classes. PMID: 29099547 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Introduction.
Authors: Saunders EFH PMID: 29099552 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Exposure and Ritual Prevention Therapy for Trichotillomania: Two Case Reports.
Authors: Brauer L, Grant JE PMID: 29099553 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans.
Authors: Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH PMID: 29099554 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Physician Characteristics Associated With Prescription of Long-Acting Injectable Antipsychotics.
Authors: Stip E PMID: 29099555 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Cost Reductions Associated With Long-Acting Injectable Antipsychotics According to Patient Age.
Authors: Stip E PMID: 29099556 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Correll and Colleagues Reply.
Authors: Correll CU, Citrome L, Haddad PM, Lauriello J, Olfson M, Kane JM PMID: 29099557 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Antidepressant Exposure During Pregnancy and Risk of Autism in the Offspring, 2: Do the New Studies Add Anything New?
CONCLUSIONS: The new studies do not change the conclusions of the available meta-analyses. In fact, at least some of the new data strengthen the conclusion that antidepressant use during pregnancy is likely to be a marker of more severe illness and that inadequately measured, unmeasured, or unknown genetic, behavioral, and environmental confounds associated with more severe illness (rather than the antidepressant exposure by itself) may be responsible for the increased risk of ASD. PMID: 29099558 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dried Blood Spot Analysis for Therapeutic Drug Monitoring of Clozapine.
CONCLUSION: DBS analysis is a reliable tool for blood sampling and performing TDM of clozapine and norclozapine in daily practice and substantially extends the opportunities for TDM of clozapine. PMID: 29068609 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Seizure Risk Associated With Antidepressant Treatment Among Patients With Depressive Disorders: A Population-Based Case-Crossover Study.
CONCLUSIONS: The seizure-inducing propensity and dose-response relationship pattern, as well as potential risk factors, associated with individual antidepressants should be taken into consideration when choosing antidepressants during clinical practice. PMID: 29068610 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Does Patient Adherence to Antidepressant Medication Actually Vary Between Physicians?
CONCLUSIONS: After accounting for sampling variation and case mix differences, early adherence to antidepressant medication varies minimally among prescribing physicians. Early discontinuation of antidepressant treatment is not an appropriate measure of individual physician performance, and efforts to improve adherence should emphasize system-level interventions rather than the performance of individual physicians. PMID: 29068611 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Placebo Effects in the Treatment of Noncognitive Symptoms of Alzheimer's Disease: Analysis of the CATIE-AD Data.
Authors: Ozawa C, Roberts R, Yoshida K, Suzuki T, Lebowitz B, Reeves S, Howard R, Abe T, Mimura M, Uchida H Abstract OBJECTIVE: To compare symptom trajectories between placebo and active drug responders and to examine whether early placebo improvement would be associated with subsequent placebo response in the treatment of patients with behavioral and psychological symptoms of dementia. METHODS: A post hoc analysis of data from 371 patients with DSM-IV Alzheimer's disease in Phase 1 of the Clinical Antipsychotic Trials of Intervention Effectiveness for Alzheimer's disease (CATIE-AD) (April 2001 to November 2004...
Source: Journal of Clinical Psychiatry - October 20, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Treatment to Enhance Cognition in Bipolar Disorder (TREC-BD): Efficacy of a Randomized Controlled Trial of Cognitive Remediation Versus Active Control.
CONCLUSIONS: Cognitive remediation produced significant improvements over an active control in several cognitive domains and the cognitive composite. While both groups improved on several domains relative to baseline, durability of gains was unique to CR. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01470781. PMID: 29045770 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 20, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

National Trends in and Correlates of Nonmedical Use of Prescription Stimulants, Nonmedical Use Frequency, and Use Disorders.
CONCLUSIONS: Among individuals aged 12-64 in the United States, after adjusting for covariates, the prevalence of nonmedical use of prescription stimulants in 2013-2014 was higher than that in 2003-2004. The results of this study help inform and target efforts to reduce prescription stimulant nonmedical use, use frequency, and use disorders. PMID: 29045771 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 20, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Epidemiology, Prevention, and Assessment of Tardive Dyskinesia and Advances in Treatment.
This article addresses the prevalence, risk factors, and prevention of TD; assessment strategies including diagnostic criteria and rating scales; and evidence for TD treatments, including 2 newly approved medications: deutetrabenazine and valbenazine. PMID: 29022654 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 14, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Anosognosia Is an Independent Predictor of Conversion From Mild Cognitive Impairment to Alzheimer's Disease and Is Associated With Reduced Brain Metabolism.
This study aimed to examine (1) the relationship between brain glucose metabolism as measured by fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and anosognosia in patients with MCI and AD and (2) the predictive utility of anosognosia in patients with MCI for later conversion to AD, even when controlling for other factors, including gender, education, apolipoprotein E ε4 carrier status, dementia severity, and cognitive dysfunction. METHODS: Data for 1,062 participants from the Alzheimer's Disease Neuroimaging Initiative database (2003 to August 2015) classified as having AD (n = 191) or MC...
Source: Journal of Clinical Psychiatry - October 14, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Implication of Combat Stress and PTSD Trajectories in Metabolic Syndrome and Elevated C-Reactive Protein Levels: A Longitudinal Study.
CONCLUSIONS: Monitoring inflammation using markers like CRP level in trauma survivors can be beneficial, particularly if PTSD is chronic or delayed. Clinicians treating trauma survivors should raise awareness of the importance of such measures in light of long-term health vulnerabilities. PMID: 28994516 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 11, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Impact of Obesity on Cognitive Functioning in Euthymic Bipolar Patients: A Cross-Sectional and Longitudinal Study.
Authors: Mora E, Portella MJ, Martinez-Alonso M, Teres M, Forcada I, Vieta E, Mur M Abstract OBJECTIVE: To determine the influence of body mass index (BMI) on cognition in euthymic bipolar patients and healthy matched controls in a post hoc study of 2 cross-sectional and longitudinal exploratory studies. METHOD: A total sample of 121 individuals was examined, which included 52 euthymic bipolar disorder I or II patients (DSM-IV-TR criteria) and 69 healthy controls matched by age and gender, categorized in 2 subgroups in terms of body mass index (BMI-factor): normal weight (BMI: 18.5-24.9 kg/m²) versus overw...
Source: Journal of Clinical Psychiatry - October 11, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Diagnosing and Treating Patients With Mixed Features.
Authors: Jain R, Maletic V, McIntyre RS PMID: 28994900 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 11, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Risk of First Onset Stroke in SSRI-Exposed Adult Subjects: Survival Analysis and Examination of Age and Time Effects.
In this study, we investigated age and time effects on the risk of first onset stroke in SSRI-exposed (SSRIEXP) adult subjects. METHODS: We analyzed an 8-year cohort from the National Health Insurance Research Database, Taiwan. Patients were defined as SSRIEXP subjects if they received SSRI prescriptions for at least 2 consecutive months during January 1, 2001, to December 31, 2007. Otherwise, they were categorized as SSRI-nonexposed (SSRINONE) subjects. Stroke diagnosis was made according to ICD-9 codes 430-432 (hemorrhagic stroke) and 433-437 (ischemic stroke). RESULTS: Kaplan-Meier survival analysis showed a gre...
Source: Journal of Clinical Psychiatry - October 11, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Corrected QT Interval and Methadone Dose and Concentrations in Pregnant and Postpartum Women.
Authors: Bogen DL, Hanusa BH, Perel JM, Sherman F, Mendelson MA, Wisner KL Abstract BACKGROUND: Methadone is a standard treatment for opioid dependence in pregnancy; however, its impact on maternal corrected QT interval (QTc) has not been evaluated. We studied the association between methadone dose and enantiomer-specific plasma concentrations and QTc among pregnant and postpartum women and newborns. We assessed the relevance of QTc screening guidelines for pregnant women and infants. METHODS: From 2006 to 2008, plasma methadone concentrations were measured during pregnancy, postpartum, and in cord blood in wom...
Source: Journal of Clinical Psychiatry - October 11, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Antidepressant Exposure During Pregnancy and Risk of Autism in the Offspring, 1: Meta-Review of Meta-Analyses.
Authors: Andrade C Abstract There are no randomized controlled trials of antidepressant drugs to treat depression, or to prevent relapse into depression, during pregnancy; therefore, the safety of antidepressant drug exposure during pregnancy is based on evidence from case-control or cohort studies. Many of these observational studies, during the past decade, examined the risk of autism spectrum disorder (ASD) in exposed offspring. Different studies using different methods and examining different periods of antidepressant exposure before and during pregnancy obtained different results. Studies with adverse outcomes...
Source: Journal of Clinical Psychiatry - October 11, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Durability of Therapeutic Response With Long-Term Aripiprazole Lauroxil Treatment Following Successful Resolution of an Acute Episode of Schizophrenia.
Authors: McEvoy JP, Risinger R, Mykhnyak S, Du Y, Liu CC, Stanford AD, Weiden PJ Abstract OBJECTIVE: To evaluate durability of therapeutic effect of long-term treatment with aripiprazole lauroxil in patients with schizophrenia following successful treatment of an acute psychotic episode. METHODS: This post hoc analysis assessed long-term outcomes for a subgroup of patients who entered a 52-week extension study after being successfully stabilized with one of 2 doses of aripiprazole lauroxil (441 or 882 mg) in a pivotal 12-week, placebo-controlled, randomized clinical trial. Durability of therapeutic effect was m...
Source: Journal of Clinical Psychiatry - September 23, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Meta-Analysis of the Antidepressant Effects of Acute Sleep Deprivation.
CONCLUSIONS: These findings support a significant effect of sleep deprivation and suggest the need for future studies on the phenotypic nature of the antidepressant response to sleep deprivation, on the neurobiological mechanisms of action, and on moderators of the sleep deprivation treatment response in depression. PMID: 28937707 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 23, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Persistent Negative Symptoms in First-Episode Psychosis: Early Cognitive and Social Functioning Correlates and Differences Between Early and Adult Onset.
Authors: Puig O, Baeza I, de la Serna E, Cabrera B, Mezquida G, Bioque M, Lobo A, González-Pinto A, Parellada M, Corripio I, Vieta E, Bobes J, Usall J, Contreras F, Cuesta MJ, Bernardo M, Castro-Fornieles J, Group TP Abstract OBJECTIVE: To characterize the early cognitive and social functioning characteristics of a sample of first-episode psychosis patients with and without persistent negative symptoms (PNS) and to examine the prevalence and cognitive and functional correlates of PNS in patients with early-onset versus adult-onset first-episode psychosis. METHODS: Participants were 235 patients with firs...
Source: Journal of Clinical Psychiatry - September 20, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder.
Authors: Benedetti F, Poletti S, Hoogenboezem TA, Locatelli C, de Wit H, Wijkhuijs AJM, Colombo C, Drexhage HA Abstract BACKGROUND: The clinical relevance of raised levels of circulating cytokines in bipolar disorder is still unclear. Cytokines influence neurotransmitters, neuroplasticity, and white matter integrity. An inconsistent literature suggests that higher cytokine levels could hamper antidepressant response. Total sleep deprivation (TSD) and light therapy (LT) prompt a rapid antidepressant response and can provide a model treatment to study predictors of response. METHODS: We studied at baseline 15 imm...
Source: Journal of Clinical Psychiatry - September 20, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Efficacy and Safety of the α7-Nicotinic Acetylcholine Receptor Agonist ABT-126 in the Treatment of Cognitive Impairment Associated With Schizophrenia: Results From a Phase 2b Randomized Controlled Study in Smokers.
CONCLUSIONS: ABT-126 did not demonstrate a procognitive effect in subjects with stable schizophrenia who smoke. A trend for improvement in negative symptoms was observed with the high dose. The safety profile of ABT-126 was similar to placebo. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01678755​. PMID: 28922590 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 20, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Baseline Characteristics and Early Response at Week 1 Predict Treatment Outcome in Adolescents With Bipolar Manic or Mixed Episode Treated With Olanzapine: Results From a 3-Week, Randomized, Placebo-Controlled Trial.
Authors: Xiao L, Ganocy SJ, Findling RL, Chang K, DelBello MP, Kane JM, Tohen M, Xiang YT, Correll CU Abstract BACKGROUND: Early predictors of response and remission in pediatric mania are lacking, requiring further study. METHODS: This was a post hoc analysis of a 3-week, randomized, placebo-controlled trial of olanzapine conducted between November 2002 and May 2005 in 161 adolescents aged 13-17 years who were diagnosed with a DSM-IV acute manic or mixed episode of bipolar I disorder. Data from the olanzapine arm were analyzed to investigate the predictive power of early response or early nonresponse (≥25% or
Source: Journal of Clinical Psychiatry - September 20, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Determining if Borderline Personality Disorder and Bipolar Disorder Are Alternative Expressions of the Same Disorder: Results From the National Epidemiologic Survey on Alcohol and Related Conditions.
CONCLUSIONS: A model with 3 positively correlated factors provided an excellent fit for the latent structure of borderline personality disorder and bipolar disorder symptoms. The pattern of pairwise correlations between the 3 factors is consistent with the clinical presentation of 2 syndromes (depression and mania) that can be characterized as a unitary psychiatric entity (bipolar disorder) and a third syndrome (borderline personality disorder) that is often comorbid with bipolar disorder. The findings converge in suggesting that bipolar disorder and borderline personality disorder are overlapping but different pathologies...
Source: Journal of Clinical Psychiatry - September 20, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Psychological Pain in Suicidality: A Meta-Analysis.
Authors: Ducasse D, Holden RR, Boyer L, Artéro S, Calati R, Guillaume S, Courtet P, Olié E Abstract OBJECTIVE: Perform a meta-analysis to quantify the association between psychological pain and current or lifetime history of suicidal ideation or suicide attempt. DATA SOURCES: Search MEDLINE, Web of Science, and PsycINFO from 1965 to 2015 for (psychache OR mental pain OR psychological pain) AND (suicid*). STUDY SELECTION: Observational case-control studies addressing the difference in psychological pain between individuals with and without current or lifetime history of suicidal ideation or sui...
Source: Journal of Clinical Psychiatry - September 7, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Risk of Suicide Attempts Among Adolescents and Young Adults With Autism Spectrum Disorder: A Nationwide Longitudinal Follow-Up Study.
Authors: Chen MH, Pan TL, Lan WH, Hsu JW, Huang KL, Su TP, Li CT, Lin WC, Wei HT, Chen TJ, Bai YM Abstract BACKGROUND: Previous studies reported a high prevalence of depression among patients with autism spectrum disorder (ASD) and suggested a relationship between ASD and suicidality. However, whether ASD independently increases the risk of attempted suicide regardless of depression has not been determined. METHODS: Using the Taiwan National Health Insurance Research Database, 5,618 adolescents aged 12-17 years and young adults aged 18-29 years with ASD (ICD-9-CM code: 299) and 22,472 age- and sex-matched contr...
Source: Journal of Clinical Psychiatry - September 7, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder.
Authors: McIntyre RS, Best MW, Bowie CR, Carmona NE, Cha DS, Lee Y, Subramaniapillai M, Mansur RB, Barry H, Baune BT, Culpepper L, Fossati P, Greer TL, Harmer C, Klag E, Lam RW, Wittchen HU, Harrison J Abstract OBJECTIVE: To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD). METHODS: Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compa...
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Introduction.
Authors: Lavretsky H PMID: 28858442 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Quality of Life, Functioning, and Depressive Symptom Severity in Older Adults With Major Depressive Disorder Treated With Citalopram in the STAR*D Study.
This study examines these outcomes before and after SSRI treatment. On the basis of prior research, we hypothesized that older adults would have worse treatment outcomes in QOL, functioning, and depressive symptom severity and that nonremitters would have worse outcomes. METHODS: A retrospective secondary data analysis was conducted from the National Institute of Mental Health-funded Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study (July 2001-September 2006). We analyzed data for 2,280 nonpsychotic adults with DSM-IV-TR-defined MDD who received citalopram monotherapy. Older adults were classified a...
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Population Approach to Guide Amisulpride Dose Adjustments in Older Patients With Alzheimer's Disease.
CONCLUSIONS: These findings argue strongly for the consideration of age- and weight-based dose adjustments in older patients with AD-related psychosis and indicate that 50 mg/d of amisulpride may be both the minimal clinically effective dose and, in those aged> 75 years, the maximally tolerated dose. PMID: 28858444 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Case Report of Biotin Treatment for Valproate-Induced Hair Loss.
Authors: Grootens KP, Hartong EGTM PMID: 28858445 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Association Between Antenatal Exposure to Selective Serotonin Reuptake Inhibitors and Autism: A Need for Further Analysis.
Authors: Shi ZY, Li YM PMID: 28858446 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Brown and Colleagues Reply.
Authors: Brown HK, Hussain-Shamsy N, Lunsky Y, Dennis CE, Vigod SN PMID: 28858447 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Severity of Binge-Eating Disorder and Its Effects on Treatment Outcome.
Authors: Dakanalis A, Clerici M PMID: 28858448 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Grilo Replies.
Authors: Grilo CM PMID: 28858449 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Ketamine for Depression, 5: Potential Pharmacokinetic and Pharmacodynamic Drug Interactions.
This article explores potential pharmacokinetic and pharmacodynamic drug interactions of relevance to the use of ketamine in depression. Sparse evidence suggests that ketamine will not induce clinically significant drug interactions except to the extent that these are predictable by its clinical actions. A small body of literature indicates that drugs that induce cytochrome P450 (CYP)2B6 and CYP3A4 will reduce exposure to ketamine and that drugs that inhibit these enzymes will increase exposure to ketamine. Common genetic polymorphisms of the CYP2B6 gene may also be associated with variations in the exposure to ketamine. H...
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Association Between Bone Mineral Density and Depressive Symptoms in a Population-Based Sample.
CONCLUSIONS: QIDS-SR₁₆ score did not significantly predict BMD in the overall DHS-2 sample. There was, however, a significant association observed in participants aged ≥ 60 years. Results suggest that diagnosis and treatment of depressive symptoms may be of clinical importance in older individuals, a subgroup at high risk for osteoporosis and fractures. PMID: 28837274 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 27, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Limited Functioning After Remission of an Anxiety Disorder as a Trait Effect Versus a Scar Effect: Results of a Longitudinal General Population Study.
We examined whether impairments in mental and physical functioning following remission are a continuation of premorbid lower functioning (trait effect), due to impairments that develop during the anxiety disorder and persist beyond recovery (scar effect), or both. METHODS: Data were derived from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a prospective psychiatric epidemiologic study among the general population with a 3-wave design (6-year follow-up, with the study starting in 2007 and ending in 2015). DSM-IV anxiety disorders were measured with the Composite International Diagnostic Interv...
Source: Journal of Clinical Psychiatry - August 18, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Preventive Effects of Lamotrigine in Bipolar II Versus Bipolar I Disorder.
CONCLUSIONS: Although the preventive effect of lamotrigine on recurrence/relapse of mood episodes in BPI has been established in a variety of clinical studies, the present study suggests that lamotrigine may be more suitable for maintenance treatment in BPII than in BPI. PMID: 28817765 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 18, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Do You Order Pharmacogenetic Testing? Why?
Authors: Goldberg JF PMID: 28796939 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 11, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research