Meta-Analysis of the Prevalence of Major Depressive Disorder Among Older Adults With Dementia.
CONCLUSIONS: Depression is common among individuals with dementia, and the type of dementia and diagnostic criteria affect prevalence estimates of DpD. Further studies are required to understand factors that lead to the development of DpD and strategies to prevent and treat DpD. PMID: 30085437 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Comprehensive Model of Predictors of Suicide Attempt in Depressed Individuals and Effect of Treatment-Seeking Behavior: Results From a National 3-Year Prospective Study.
CONCLUSIONS: This model may help identify high-risk individuals with MDE and inform future research on risk of suicide. PMID: 30085438 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Adverse Pregnancy Outcomes Associated With Gestational Exposure to Antiepileptic Drugs.
This article critically examines the risk of fetal loss, intrauterine growth retardation (IUGR), and preterm birth following gestational exposure to 14 AEDs, based on information obtained from a recent network meta-analysis of mostly nonrandomized, observational studies. The AEDs studied were carbamazepine, clobazam, clonazepam, ethosuximide, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, phenobarbitone, phenytoin, primidone, topiramate, valproate, and vigabatrin. The results show that very few AEDs are significantly associated with each adverse outcome and that the implicated AEDs are different for different outco...
Source: Journal of Clinical Psychiatry - August 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Effect of Lurasidone on Sexual Function in Major Depressive Disorder Patients With Subthreshold Hypomanic Symptoms (Mixed Features): Results From a Placebo-Controlled Trial.
Authors: Clayton AH, Tsai J, Mao Y, Pikalov A, Loebel A Abstract OBJECTIVE: The aim of this secondary analysis was to evaluate whether treatment with lurasidone was associated with impairment in sexual functioning in major depressive disorder (MDD) patients with subthreshold hypomanic symptoms (mixed features). METHODS: Patients meeting DSM-IV-TR criteria for MDD, who presented with 2 or 3 protocol-specified manic symptoms, were randomized to 6 weeks of double-blind treatment with flexible doses of either lurasidone 20-60 mg/d (n = 109) or placebo (n = 100). The study was conducted between September 2011 and Oc...
Source: Journal of Clinical Psychiatry - August 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Further Evidence of Morbidity and Dysfunction Associated With Subsyndromal ADHD in Clinically Referred Children.
Authors: Biederman J, Fitzgerald M, Kirova AM, Woodworth KY, Biederman I, Faraone SV Abstract BACKGROUND: While the diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD) have evolved over the years, some children with impairing ADHD symptoms fail to meet the full diagnostic threshold for the disorder. The main aim of this study was to evaluate the morbidity and dysfunction of subsyndromal ADHD in the clinical setting. METHODS: Subthreshold and full ADHD subjects were derived from consecutive referrals (n = 2,947) to a pediatric psychopharmacology program at a major academic center. Subjects we...
Source: Journal of Clinical Psychiatry - August 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Prevalence and Clinical Correlates of and Cognitive Function at the Time of Suicide Attempts in First-Episode and Drug-Naive Patients With Schizophrenia.
CONCLUSIONS: FEDN patients with schizophrenia attempt suicide more often than the general population. The suicidal patients were more likely to smoke, had lower severity of negative symptoms, and showed better attention than nonsuicidal patients. PMID: 30063302 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 3, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Appetitive Symptoms Differentially Predict Treatment Response to Fluoxetine, Light, and Placebo in Nonseasonal Major Depression.
Authors: Levitan RD, Levitt AJ, Michalak EE, Morehouse R, Ramasubbu R, Yatham LN, Tam EM, Lam RW Abstract OBJECTIVE: We previously reported that morning bright light therapy is efficacious in adults with nonseasonal major depressive disorder (MDD), both on its own and in combination with fluoxetine. Given that appetitive symptoms predict response to bright light therapy in seasonal depression, we examined, in this secondary analysis, whether the same held true in these nonseasonal MDD patients. METHODS: Data were collected from October 7, 2009, to March 11, 2014. One hundred twenty-two patients who met DSM-IV-T...
Source: Journal of Clinical Psychiatry - August 3, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Acute and Longer-Term Outcomes Using Ketamine as a Clinical Treatment at the Yale Psychiatric Hospital.
CONCLUSIONS: In general, ketamine infusions were tolerated well. The response and remission rates in this clinical sample were lower than those observed in some research protocols. The small number of patients who were treated on a maintenance schedule limits the conclusions that can be drawn regarding the long-term safety of ketamine; however, no long-term adverse effects were observed in this sample. PMID: 30063304 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 3, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Parkinson Disease: Current and Emerging Treatment Strategies.
Authors: Ramirez-Zamora A Abstract Although levodopa is effective for treating Parkinson disease, physicians and patients face significant management challenges related to disease progression. Patients may develop fluctuations in motor symptoms and dyskinesias as well as nonmotor symptoms. Review this CME Brief Report activity to learn about new and emerging treatment options to manage patients' symptoms. PMID: 29999254 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 14, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Predicting Initial Specialist Mental Health Care Use in Adolescence Using Self-, Parent-, and Teacher-Reported Problem Behavior: A Prospective Community-Based Record-Linkage Study.
Authors: Raven D, Jörg F, Visser E, Schoevers RA, Oldehinkel AJ Abstract OBJECTIVE: The aim of this study was to determine the relative importance of self-, parent-, and teacher-reported problem behavior for initial specialist mental health care use in adolescence and the extent to which the relative importance of each informant changes over time. METHODS: Data from the Dutch community-based cohort study TRacking Adolescents' Individual Lives Survey (TRAILS) were linked to administrative records of specialist mental health care organizations. Self-, parent-, and teacher-reported internalizing and externali...
Source: Journal of Clinical Psychiatry - July 12, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study.
CONCLUSIONS: This early study suggests that adjunctive treatment with a standardized extract of Withania somnifera provides significant benefits, with minimal side effects, for negative, general, and total symptoms and stress in patients with recent exacerbation of schizophrenia. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01793935. PMID: 29995356 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 12, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Modes of Resting Functional Brain Organization Differentiate Suicidal Thoughts and Actions: A Preliminary Study.
CONCLUSIONS: Measures of intrinsic brain organization may have practical value as objective measures of suicide risk and its underlying mechanisms. Further incorporation of serum or cognitive markers and use of a prospective study design are needed to validate and refine the clinical relevance of this candidate biomarker of suicide risk. PMID: 29995357 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 12, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Longitudinal Epidemiologic Study of Poor Mental Health Status in Japanese Adolescents: Incidence of Predictive Lifestyle Factors.
Authors: Itani O, Kaneita Y, Doi K, Tokiya M, Jike M, Nakagome S, Otsuka Y, Ohida T Abstract OBJECTIVE: To clarify the incidence of predictive risk factors for poor mental health status in Japanese adolescents. METHODS: In 2010, baseline surveys of first-year junior and senior high school students were conducted at 10 randomly selected junior high schools and 14 senior high schools in Japan. After 2 years, follow-up surveys were conducted on the same students. For both surveys, a self-administered questionnaire about mental health status and lifestyle, General Health Questionnaire-12 (GHQ-12), was provided to t...
Source: Journal of Clinical Psychiatry - July 12, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Efficacy of Tianeptine 25-50 mg in Elderly Patients With Recurrent Major Depressive Disorder: An 8-Week Placebo- and Escitalopram-Controlled Study.
Authors: Emsley R, Ahokas A, Suarez A, Marinescu D, Dóci I, Lehtmets A, Milanova V, Lee MS, Didi R, Araszkiewicz A, Sulaiman AH, Blanchot FP, Crutel VS, Antoine C, Penelaud PF Abstract OBJECTIVE: The present placebo-controlled study evaluated the efficacy and safety of 8 weeks of treatment with tianeptine 25-50 mg/d in elderly patients suffering from major depressive disorder (MDD) according to DSM-IV-TR. Escitalopram 5-10 mg/d was used as an active comparator. METHODS: Elderly outpatients aged at least 65 years with a primary diagnosis of moderate to severe episode of recurrent MDD were recruited by psy...
Source: Journal of Clinical Psychiatry - July 12, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Psychiatric Disorders and Comorbid Cannabis Use: How Common Is It and What Is the Clinical Impact?
Authors: Satre DD, Bahorik A, Zaman T, Ramo D PMID: 29985564 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 11, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Prescribing Trends in US Active Duty Service Members With Posttraumatic Stress Disorder: A Population-Based Study From 2007-2013.
CONCLUSIONS: The increase in SSRI or SNRI prescribing after 2010 and the overall increase in prazosin and decrease in low-dose quetiapine prescribing all suggest increased concordance with the VA/DoD PTSD Clinical Practice Guidelines. The decline in SSRI prescribing up to 2010 is not concordant. The increase in benzodiazepine prescribing, a trend opposite that observed in the VA, is concerning. PMID: 29985565 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 11, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Double-Blind Placebo-Controlled Trial of Omega-3 Fatty Acids as a Monotherapy for Adolescent Depression.
Authors: Gabbay V, Freed RD, Alonso CM, Senger S, Stadterman J, Davison BA, Klein RG Abstract OBJECTIVE: Reports are mixed on the efficacy of omega-3 fatty acids (O3FA) for the treatment of major depressive disorder (MDD), with only limited data in adolescents. The present trial aimed to investigate systematically the efficacy of O3FA as a monotherapy, compared to a placebo, in adolescents with MDD. Secondarily, we explored O3FA effects on anhedonia, irritability, and suicidality-all key features of adolescent MDD. METHODS: Fifty-one psychotropic medication-free adolescents with DSM-IV-TR diagnoses of MDD (aged...
Source: Journal of Clinical Psychiatry - July 11, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Clinical Predictors of Extrapyramidal Symptoms Associated With Aripiprazole Augmentation for the Treatment of Late-Life Depression in a Randomized Controlled Trial.
CONCLUSIONS: Akathisia is a common side effect of aripiprazole, but it is typically mild and responds to dose reduction. Patients with greater baseline depression may warrant closer monitoring for akathisia. More research is needed to understand the course and predictors of treatment-emergent EPS with antipsychotic augmentation for treatment-resistant LLD. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00892047. PMID: 29924506 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 25, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Relapse After Antipsychotic Discontinuation in Schizophrenia as a Withdrawal Phenomenon vs Illness Recurrence: A Post Hoc Analysis of a Randomized Placebo-Controlled Study.
CONCLUSIONS: Findings suggest that relapses after treatment discontinuation reflect recurrence of the underlying illness and may be consistent with a hypothesis of direct relationship between dopamine and psychosis. No evidence was obtained for withdrawal-related phenomena contributing to the high relapse rates after treatment discontinuation. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00111189. PMID: 29924507 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 25, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Trends in Illicit Drug Use Among Smokers and Nonsmokers in the United States, 2002-2014.
CONCLUSIONS: Illicit drug use is most prevalent among current cigarette smokers. Yet, the rate of increase in illicit drug use prevalence was most rapid among former smokers. Because former smokers outnumber current smokers in the general population, it may be important to monitor former smokers into the future for potential negative drug-related outcomes. PMID: 29894597 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 14, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Neural Responsiveness to Reward as an Index of Depressive Symptom Change Following Cognitive-Behavioral Therapy and SSRI Treatment.
Authors: Burkhouse KL, Gorka SM, Klumpp H, Kennedy AE, Karich S, Francis J, Ajilore O, Craske MG, Langenecker SA, Shankman SA, Hajcak G, Phan KL Abstract OBJECTIVE: Reward positivity (RewP), a neurophysiologic index of reward responsivity, is consistently reduced in participants with depression and, to a lesser extent, anxiety. It remains unknown, however, whether RewP can be altered as psychiatric symptoms change with treatment. The current study addressed this question by examining differences in RewP within patients before and after 12 weeks of treatment with a selective serotonin reuptake inhibitor (SSRI) or co...
Source: Journal of Clinical Psychiatry - June 14, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Reevaluating Sensitivity of Self-Reported Suicidal Ideation.
Authors: Ludman EJ, Simon GE, Whiteside U, Richards JE, Pabiniak C PMID: 29873950 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Sedative Hypnotics and the Risk of Falls and Fractures in the Elderly.
Authors: Andrade C Abstract Older age, poor sleep, and the use of the "Z" sedative hypnotic drugs (zopiclone, eszopiclone, zolpidem, and zaleplon) commonly go together. Each of these can increase the risk of falls and fractures through mechanisms related to cognitive and psychomotor impairment. A recent systematic review and meta-analysis examined the risk of falls and fractures associated with the use of the Z-drugs. The authors of that meta-analysis identified 14 relevant cohort and case-control studies. They found that Z-drugs increased the risk of falls in 2 out of 3 studies that provided information ...
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Working With Decisionally Capable Patients Who Are Determined to End Their Own Lives.
Authors: Yager J, Ganzini L, Nguyen DH, Rapp EK Abstract Psychiatrists face complex, vexing, and often conflicting issues in assessing and managing patients with advanced medical illnesses who are determined to end their own lives. Substantial differences of opinion exist among psychiatrists regarding the roles they might take with such patients when the patients are decisionally capable and do not have clear-cut psychiatric disorders. Even those with psychiatric diagnoses often possess rational deliberative abilities and may make decisions to hasten death that are not impacted by their psychiatric disorder. How ps...
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Randomized, Placebo-Controlled Study of the Efficacy and Safety of Fixed-Dose Brexpiprazole 2 mg/d as Adjunctive Treatment of Adults With Major Depressive Disorder.
CONCLUSIONS: This study adds to the substantial body of evidence for the efficacy and tolerability of brexpiprazole as adjunctive treatment in patients with MDD and inadequate response to ADTs. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02196506; EudraCT number: 2014-000062-22​​​. PMID: 29873953 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dose Increase Versus Unchanged Continuation of Antidepressants After Initial Antidepressant Treatment Failure in Patients With Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized, Double-Blind Trials.
CONCLUSIONS: With clinically and statistically nonsignificant effect estimates, there is evidence from RCTs against increasing the dose of SSRIs (with the possible exception of citalopram) in adult patients with major depression and ATF. Dose increase with other antidepressants (eg, tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, monoamine oxidase inhibitors) and in other patient groups (minor depression, children and adolescents) or after long periods of first-line antidepressant therapy (ie, 8 weeks) have not been or not been sufficiently studied and, at this time, cannot be recommended in clinic...
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Risk Factors Associated With Antidepressant Exposure and History of Antidepressant-Induced Mania in Bipolar Disorder.
CONCLUSIONS: These data suggest that there are certain identifiable factors associated with antidepressant exposure in bipolar disorder patients, and some of these, specifically female sex, are also associated with a history of AIM. These data may be useful in designing prospective trials to identify interventions that can reduce the risk of this adverse outcome. PMID: 29873955 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Cognitive Effects of MIN-101 in Patients With Schizophrenia and Negative Symptoms: Results From a Randomized Controlled Trial.
CONCLUSIONS: Results suggest a possible benefit of MIN-101 on cognitive performance in individuals with schizophrenia with stable positive symptoms and concurrent clinically significant negative symptoms. TRIAL REGISTRATION: EU Clinical Trials Register identifier: 2014-004878-42​. PMID: 29873956 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Incidence of, Risk Factors for, and Changes Over Time in Treatment-Resistant Depression in Denmark: A Register-Based Cohort Study.
CONCLUSIONS: About 14% of patients with depression developed TRD during the first year after first hospital contact. The incidence was highest in patients with severe depression and was relatively stable over time. Various definitions of TRD provided different estimates of the frequency of TRD but were all associated with disease severity. PMID: 29873959 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

US Food and Drug Administration's Approval of Aripiprazole Tablets With Sensor: Our Perspective.
Authors: Lee DJ, Farchione TR, Mathis MV, Muniz J, Muoio BM PMID: 29873960 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Valproate in Pregnancy: Recent Research and Regulatory Responses.
Authors: Andrade C Abstract Valproate and formulations thereof are approved for the management of seizure disorders, bipolar disorder, and migraine. Valproate is also used for many off-label indications. Unfortunately, data from observational studies indicate that valproate is perhaps the most teratogenic drug in the neuropsychiatric pharmacopeia. It is significantly more teratogenic than many other antiepileptic drugs (AEDs). In observational studies, gestational exposure to valproate is also associated with higher risks of cognitive, language, and psychomotor delay during early childhood and possibly with an incr...
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Internet Addiction and Its Relationship With Suicidal Behaviors: A Meta-Analysis of Multinational Observational Studies.
CONCLUSIONS: This meta-analysis provides evidence that internet addiction is associated with increased suicidality even after adjusting for potential confounding variables including depression. However, the evidence was derived mostly from cross-sectional studies. Future prospective studies are necessary to confirm these findings. PMID: 29877640 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Association of Cannabis With Long-Term Clinical Symptoms in Anxiety and Mood Disorders: A Systematic Review of Prospective Studies.
CONCLUSIONS: Recent cannabis use was associated with negative long-term symptomatic and treatment outcomes across AMD. The findings should be interpreted with caution, considering the observational designs across studies and the biases associated with the samples (eg, inpatients) and sources of cannabis consumed (ie, unregulated sources). Nonetheless, clinicians can use the insight gained to inform their own and their patients' knowledge concerning potential risks of cannabis with regard to symptoms of AMD. PMID: 29877641 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Revisiting the Abnormal Involuntary Movement Scale: Proceedings From the Tardive Dyskinesia Assessment Workshop.
CONCLUSIONS: For both research and clinical practice, the AIMS is a valid measure for assessing TD and the effects of treatment, but alternative analyses of AIMS data (eg, effect size, minimal clinically important difference, response analyses, category shifts) may provide broader evidence of clinical effectiveness. No single analysis of AIMS data can be considered the standard of clinical efficacy; multiple analytic approaches are recommended. PMID: 29742330 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 11, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Youth With Autism Spectrum Disorder in the Emergency Department.
CONCLUSIONS: This review found significant gaps in the literature related to ED service use by youth with ASD. More research is needed to avoid unnecessary ED utilization and hospitalization, reduce medical costs, and improve outcome for youth with ASD. PMID: 29742331 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 11, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Clinical Features of Auditory Hallucinations in Patients With Dementia With Lewy Bodies: A Soundtrack of Visual Hallucinations.
Authors: Tsunoda N, Hashimoto M, Ishikawa T, Fukuhara R, Yuki S, Tanaka H, Hatada Y, Miyagawa Y, Ikeda M Abstract OBJECTIVE: Auditory hallucinations are an important symptom for diagnosing dementia with Lewy bodies (DLB), yet they have received less attention than visual hallucinations. We investigated the clinical features of auditory hallucinations and the possible mechanisms by which they arise in patients with DLB. METHODS: We recruited 124 consecutive patients with probable DLB (diagnosis based on the DLB International Workshop 2005 criteria; study period: June 2007-January 2015) from the dementia referral...
Source: Journal of Clinical Psychiatry - May 11, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Risk of Type 2 Diabetes in Adolescents and Young Adults With Attention-Deficit/Hyperactivity Disorder: A Nationwide Longitudinal Study.
DISCUSSION: Adolescents and young adults with ADHD were more likely than non-ADHD controls to develop type 2 DM in later life. In addition, those with ADHD taking atypical antipsychotics exhibited a higher risk. Although correlation does not equal causation, our findings merit further study about the relationship between ADHD and type 2 DM. PMID: 29727071 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Randomized Controlled Trials of Psychoeducation Modalities in the Management of Bipolar Disorder: A Systematic Review.
CONCLUSIONS: Future studies may include direct comparisons of different psychoeducation modalities to elucidate specific benefits of unique psychoeducation interventions at different phases of bipolar disorder. PMID: 29727072 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Efficacy, Safety, and Durability of Repeated Ketamine Infusions for Comorbid Posttraumatic Stress Disorder and Treatment-Resistant Depression.
Authors: Albott CS, Lim KO, Forbes MK, Erbes C, Tye SJ, Grabowski JG, Thuras P, Batres-Y-Carr TM, Wels J, Shiroma PR Abstract OBJECTIVE: The present study examined the efficacy, safety, and durability of repeated ketamine infusions for the treatment of comorbid posttraumatic stress disorder (PTSD) and treatment-resistant depression (TRD) in a sample of veterans. METHODS: Individuals with comorbid DSM-5-defined PTSD and DSM-IV-defined major depressive disorder (N = 15) received 6 intravenous ketamine infusions (0.5 mg/kg) on a Monday-Wednesday-Friday schedule over a 12-day period from May 2015 to June 2016. Data...
Source: Journal of Clinical Psychiatry - May 8, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Distinguishing Between Borderline Personality Disorder and Bipolar Disorder.
Authors: di Giacomo E, Colmegna F, Aspesi F, Dakanalis A, Clerici M PMID: 29718595 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 4, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Gonzalez-Pinto and Colleagues Reply.
Authors: Gonzalez-Pinto A, Oquendo MA, Stanley B, de la Rosa I, Garcia G, Liu SM, Blanco C PMID: 29718596 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 4, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

No Changes in Gray Matter Density or Cortical Thickness in Late-Life Minor Depression.
Authors: Polyakova M, Mueller K, Sander C, Beyer F, Witte V, Lampe L, Then F, Riedel-Heller S, Hoffmann KT, Villringer A, Schroeter ML, Schoenknecht P PMID: 29718597 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 4, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Does a Meta-Analysis of Sleep Deprivation Studies Demonstrate Efficacy?
Authors: Stewart JW PMID: 29718598 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 4, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Drs Boland and Gehrman Reply.
Authors: Boland EM, Gehrman PR PMID: 29718599 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 4, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Relative Efficacy and Acceptability of Antidepressant Drugs in Adults With Major Depressive Disorder: Commentary on a Network Meta-Analysis.
Authors: Andrade C Abstract A large number of antidepressant drugs are available across the world. All have been compared against placebo, and many have been compared with some but not all other antidepressants. There is therefore little information about a hierarchy of the efficacy and acceptability of these drugs. About 9 years ago, a network meta-analysis attempted to rank the efficacy and acceptability of 12 newer antidepressant drugs in adults with major depressive disorder. Very recently, this network meta-analysis was updated to include 21 antidepressant drugs, most of which were introduced during the 1980s ...
Source: Journal of Clinical Psychiatry - May 4, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Diagnosing Bipolar Disorder in Pediatric Patients.
Authors: Chang KD Abstract As many as 2 million youths in the US alone could have bipolar disorder. In this CME brief report, get up-to-date on common presentations of pediatric bipolar disorder, DSM-5 diagnostic criteria, and structured interviews and screening tools that can help you detect manic symptomatology. PMID: 29718601 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 4, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Treating Bipolar Disorder in Adolescents.
Authors: Findling RL Abstract How do you select among treatments for bipolar disorder in adolescents? Check out this brief report activity to explore the efficacy and safety of lithium, anticonvulsants, and atypical antipsychotics in the treatment of adolescent bipolar disorder. Plus, receive guidance for monitoring for common adverse effects, such as weight gain and fatigue. PMID: 29718602 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 4, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Commentary on Existential Psychopharmacologic Clinical Practice: Advocating a Humanistic Approach to the "Med Check".
A Commentary on Existential Psychopharmacologic Clinical Practice: Advocating a Humanistic Approach to the "Med Check". J Clin Psychiatry. 2018 Apr 24;79(4): Authors: Ghaemi SN, Glick ID, Ellison JM PMID: 29701934 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - April 29, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Risk Factors for Overdose in Treatment-Seeking Youth With Substance Use Disorders.
We examined the medical records of 200 patients (157 males and 43 females) with a mean ± SD age of 20.2 ± 2.8 years. At intake, 58 patients (29%) had a history of OD, and 62% of those patients had a history of unintentional OD only (n = 36). Youth with ≥ 2 SUDs were 3 times more likely to have a history of OD compared to youth with 1 SUD (all P
Source: Journal of Clinical Psychiatry - April 29, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Impact of Captivity and Posttraumatic Stress Disorder on Cognitive Performance Among Former Prisoners of War: A Longitudinal Study.
This study assesses the effect of captivity, PTSD trajectories, and the accumulating differential effect in the prediction of cognitive performance. METHODS: This longitudinal research includes 4 assessments (1991 [T1], 2003 [T2], 2008 [T3], 2015 [T4]) of Israeli ex-POWs and comparable combatants from the 1973 Yom Kippur War. Accordingly, 95 ex-POWs and 26 comparable combatants were included in this study. PTSD was assessed according to the DSM-IV, and cognitive performance was assessed using the Montreal Cognitive Assessment (MoCA). RESULTS: Ex-POWs reported higher levels of PTSD symptoms compared to controls (P =...
Source: Journal of Clinical Psychiatry - April 29, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research