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Antipsychotic Medication Treatment Patterns in Adult Depression.
CONCLUSION: Antipsychotic medications are used in approximately 1 in 7 patients with a new episode of depression. For 1 in 12 patients, the antipsychotic was considered to be intended for nonpsychotic depression. Almost three-quarters of these patients did not receive minimally adequate treatment with antidepressants prior to antipsychotic initiation. This pattern suggests potentially inappropriate and premature initiation of a drug class with substantial adverse effects and medical risks. PMID: 28686818 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Differential Risk of Increasing Psychotropic Polypharmacy Use in Children Diagnosed With ADHD as Preschoolers.
CONCLUSIONS: Psychotropic polypharmacy, antipsychotic, and anticonvulsant use increased with each year of follow-up. This effect was strongly mediated by the age of ADHD diagnosis with substantial increases in preschoolers but no corresponding effect in older children. It was only partially explained by physician diagnoses of concomitant mental disorders. PMID: 28686819 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Cannabis Use and Cannabis Use Disorders Among Youth in the United States, 2002-2014.
This study used data from 288,300 persons aged 12-17 years who participated in the 2002-2014 National Survey on Drug Use and Health. Descriptive analyses and bivariable and multivariable logistic regressions were applied (using the year 2002 as the reference group for most analyses). RESULTS: The prevalence of past-year CU among youth decreased from 15.8% in 2002 to 13.1% in 2014 (this downward trend occurred during 2002-2007 only [β = -0.0540, P
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Gauging the Use of Second-Generation Antipsychotics: Medicaid Benefits Data Suggest Much Room for Improvement.
Authors: Thase ME PMID: 28686821 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Mindfulness-Based Stress Reduction for Older Adults With Stress Disorders and Neurocognitive Difficulties: A Randomized Controlled Trial.
CONCLUSIONS: In this population of older adults with stress disorders and neurocognitive difficulties, a mindfulness intervention improves clinical outcomes such as excessive worry and depression and may include some forms of immediate memory performance. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01693874. PMID: 28686822 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Enhancing Extinction Learning in Posttraumatic Stress Disorder With Brief Daily Imaginal Exposure and Methylene Blue: A Randomized Controlled Trial.
CONCLUSIONS: The findings provide preliminary efficacy for a brief IE treatment for PTSD and point to the potential utility of MB for enhancing outcome. Brief interventions and better tailoring of MB augmentation strategies, adjusting for observed patterns, may have the potential to reduce dropout, accelerate change, and improve outcomes. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01188694. PMID: 28686823 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research.
CONCLUSIONS: S-adenosylmethionine holds promise as a treatment for multiple neuropsychiatric conditions, but the body of evidence has limitations. The encouraging findings support further study of SAMe in both psychiatric and comorbid medical illnesses. PMID: 28682528 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Risk of Irritability With Psychostimulant Treatment in Children With ADHD: A Meta-Analysis.
CONCLUSIONS: This meta-analysis suggests an increased risk of irritability may be confined to amphetamine-derived psychostimulants. Future meta-analyses examining the effects of amphetamine and methylphenidate derivatives on irritability as a continuous measure, as well as head-to-head trials between methylphenidate and amphetamine derivatives examining effects on irritability, will be important to replicate the findings of this meta-analysis. PMID: 28682529 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Acute Substance Use as a Warning Sign for Suicide Attempts: A Case-Crossover Examination of the 48 Hours Prior to a Recent Suicide Attempt.
CONCLUSIONS: Findings suggest the importance of considering acute alcohol use and use of CNS depressants, and the concurrent use of both substances, when evaluating short-term risk for suicide attempts in clinical settings. PMID: 28682530 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Florida Best Practice Psychotherapeutic Medication Guidelines for Adults With Major Depressive Disorder.
CONCLUSIONS: The updated 2015 FPG provide concise, pragmatic, evidence-based decision support for treatment selection and sequencing for adults with MDD. Principles of practice include measurement-based care, priority to both psychiatric and medical comorbidity, identification of DSM-5-defined specifiers (eg, mixed features), suicide risk assessment, and evaluation of cognitive symptoms. The FPG have purposefully aimed to minimize emphasis on "expert opinion" and instead differentially emphasized extant evidence for pharmacologic treatments. PMID: 28682531 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Introduction: Identifying the Patients Most at Risk for Suicide Beyond Suicidal Ideation.
Authors: Courtet P PMID: 28682532 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Assessment of Suicidal Ideation and Behavior: Report of the International Society for CNS Clinical Trials and Methodology Consensus Meeting.
CONCLUSIONS: All 5 working groups agreed that a major barrier to advancement of the field of SI/SB research and the development of new treatments for SI/SB remains the lack of a universally accepted standardized nomenclature and classification system. Achieving alignment on definitions and classification of suicide-related phenomena is critical to improving the detection and assessment of SI/SB, the design of clinical trials for new treatments, and effective public health interventions. PMID: 28682533 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Objectively Assessed Sleep Variability as an Acute Warning Sign of Suicidal Ideation in a Longitudinal Evaluation of Young Adults at High Suicide Risk.
Authors: Bernert RA, Hom MA, Iwata NG, Joiner TE Abstract OBJECTIVE: Young adults attempt suicide at disproportionately high rates relative to other groups and demonstrate high rates of sleep disturbance. No study has yet prospectively evaluated disturbed sleep as an acute indicator of risk using an objective index of sleep. We investigated objective and subjective parameters of disturbed sleep as a warning sign of suicidal ideation among young adults over an acute period. METHODS: A longitudinal study across a 21-day observation period and 3 time points. Fifty of 4,847 participants (aged 18-23 years) were pres...
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Low Nitric Oxide and High C-Reactive Protein in Depression: Not a Paradox!
Authors: Oxenkrug G PMID: 28682535 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Ketamine for Depression, 3: Does Chirality Matter?
This article examines preclinical and clinical literature on the antidepressant properties of S-ketamine. Animal data suggest potential advantages for R-ketamine over S-ketamine. Case reports, case series, and some small randomized controlled trials suggest that single or repeated intravenous infusions (0.2-0.4 mg/kg) or intranasal administrations (28-84 mg) of S-ketamine have antidepressant action in patients with medication-refractory depression and that the observed benefits are similar in magnitude to the antidepressant benefits reported with racemic ketamine. However, there are no direct comparisons between S-ketamine...
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Independent Effects of Apolipoprotein E and Cerebrovascular Burden on Later-Life Depression: The Wisconsin Longitudinal Study.
CONCLUSIONS: The present findings suggest that APOE may influence expression of depressive symptomatology as adults age into and beyond their mid-70s but do not indicate APOE as a moderator of vascular depression. Results posit a potential explanation for inconsistent past findings. PMID: 28640987 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 25, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Does Half-Life Matter After Antipsychotic Discontinuation? A Relapse Comparison in Schizophrenia With 3 Different Formulations of Paliperidone.
Authors: Weiden PJ, Kim E, Bermak J, Turkoz I, Gopal S, Berwaerts J Abstract OBJECTIVE: To evaluate the effect of 1 oral and 2 distinct long-acting injectable (LAI) formulations of the same antipsychotic on times to relapse following medication discontinuation. METHODS: Data were drawn from 3 similarly designed, multicenter, double-blind, placebo-controlled, randomized-withdrawal studies of paliperidone in adults with a schizophrenia diagnosis (according to DSM-IV criteria for ≥ 1 year before screening): once-daily extended-release oral paliperidone (ORAL paliperidone), once-monthly paliperidone palmitate (P...
Source: Journal of Clinical Psychiatry - June 25, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Stimulant Treatment Trajectories Are Associated With Neural Reward Processing in Attention-Deficit/Hyperactivity Disorder.
Authors: Schweren LJS, Groenman A, von Rhein D, Weeda W, Faraone SF, Luman M, van Ewijk H, Heslenfeld DJ, Franke B, Buitelaar JK, Oosterlaan J, Hoekstra PJ, Hartman CA Abstract OBJECTIVE: The past decades have seen a surge in stimulant prescriptions for the treatment of attention-deficit/hyperactivity disorder (ADHD). Stimulants acutely alleviate symptoms and cognitive deficits associated with ADHD by modulating striatal dopamine neurotransmission and induce therapeutic changes in brain activation patterns. Long-term functional changes after treatment are unknown, as long-term studies are scarce and have focused on...
Source: Journal of Clinical Psychiatry - June 25, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Opiate Antagonists Do Not Interfere With the Clinical Benefits of Stimulants in ADHD: A Double-Blind, Placebo-Controlled Trial of the Mixed Opioid Receptor Antagonist Naltrexone.
CONCLUSIONS: Our findings provide support for the concept of combining opioid receptor antagonists with stimulants to provide an effective stimulant formulation with less abuse potential. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01673594​. PMID: 28640990 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 25, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Risk Algorithm for the Persistence of Suicidal Thoughts and Behaviors During College.
CONCLUSIONS: An individualized web-based screening approach is a promising strategy to identify students at the time of university entrance who may be at high risk for STB persistence during their academic career. PMID: 28640991 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 25, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Psychotropic Medications in Swedish Homicide Victims and Offenders: A Forensic-Toxicological Case-Control Study of Adherence and Recreational Use.
CONCLUSIONS: Nonadherence to medications used to treat affective and psychotic disorders appears to elevate the risk of homicide offending. Both medicinal and recreational use of GABAergic hypnotics appears to elevate the risk of homicide offending and victimization. In summary, vigilance regarding adherence to medications prescribed for mood disorders and psychosis, as well as restrictiveness regarding licit and illicit access to addictive hypnotics, might contribute to a reduction of homicidal violence. PMID: 28617565 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 16, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Randomized, Double-Blind, Placebo-Controlled Trial of N-Acetylcysteine Augmentation for Treatment-Resistant Obsessive-Compulsive Disorder.
Authors: Costa DLC, Diniz JB, Requena G, Joaquim MA, Pittenger C, Bloch MH, Miguel EC, Shavitt RG Abstract OBJECTIVE: To evaluate the efficacy of serotonin reuptake inhibitor (SRI) augmentation with N-acetylcysteine (NAC), a glutamate modulator and antioxidant medication, for treatment-resistant obsessive-compulsive disorder (OCD). METHODS: We conducted a randomized, double-blind, placebo-controlled, 16-week trial of NAC (3,000 mg daily) in adults (aged 18-65 years) with treatment-resistant OCD, established according to DSM-IV criteria. Forty subjects were recruited at an OCD-specialized outpatient clinic at a ...
Source: Journal of Clinical Psychiatry - June 16, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Introducing JCP Weekly.
Authors: Shelton JS PMID: 28570790 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Patients With Co-Occurring Bipolar Disorder and Posttraumatic Stress Disorder: A Rapid Review of the Literature.
CONCLUSIONS: Bipolar disorder and PTSD commonly co-occur and result in greater symptom burden than either condition alone. Few published treatment strategies exist for patients with both conditions. PMID: 28570791 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Pilot, Randomized Controlled Study of Tai Chi With Passive and Active Controls in the Treatment of Depressed Chinese Americans.
CONCLUSIONS: As the primary treatment, tai chi improved treatment outcomes for Chinese Americans with MDD over both passive and active control groups. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01619631. PMID: 28570792 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Anticonvulsant Medication Use in Veterans With Posttraumatic Stress Disorder.
CONCLUSIONS: A large and increasing proportion of veterans with PTSD receives anticonvulsant prescriptions. However, this may be appropriate use driven by increased prevalence of comorbid conditions that may be an indication for anticonvulsant use, including pain and headache disorders. PMID: 28570793 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Usual Course of Treatment and Predictors of Treatment Utilization for Patients With Posttraumatic Stress Disorder.
CONCLUSIONS: Many patients with a primary diagnosis of PTSD do not receive psychotherapy, and psychiatric prescriptions, including atypical antipsychotics and benzodiazepines, are common. Future research is needed to determine the quality of care received and explore subpopulation-specific barriers limiting access to care. PMID: 28570794 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Introduction.
Authors: Freeman MP PMID: 28570795 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Neonatal Discontinuation Syndrome in Serotonergic Antidepressant-Exposed Neonates.
CONCLUSIONS: The presence of neonatal signs at 2-4 weeks was more closely associated with prematurity than with in utero SRI or mood disorder exposure. TRIAL REGISTRATION: ClinicalTrials.gov identifiers: NCT00279370 and NCT00585702. PMID: 28570796 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Depression and Anxiety in the Postpartum Period and Risk of Bipolar Disorder: A Danish Nationwide Register-Based Cohort Study.
CONCLUSIONS: First-onset nonpsychotic postpartum affective disorder can be a marker of underlying bipolarity. Women who fill an antidepressant prescription following childbirth should be asked about hypomanic or manic symptoms and monitored long term. Clinically, when antidepressant monotherapy is ineffective or the individual woman experiences persistent and concerning symptoms, health professionals should consider a possible bipolar spectrum disorder. PMID: 28570797 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Potential Gap in the Perinatal Depression Treatment Cascade.
Authors: Dama M, Van Lieshout RJ, Steiner M PMID: 28570798 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Cox and Colleagues Reply.
Authors: Cox EQ, Sowa NA, Meltzer-Brody SE, Gaynes BN PMID: 28570799 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Correction.
Authors: PMID: 28570800 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Lurasidone-Induced Rabbit Syndrome: A Case Report.
Authors: Reichenberg JL, Ridout KK, Rickler KC PMID: 28570801 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Sensitive and Personalized Determinations of Likelihood of Being Helped or Harmed.
Authors: Ketter TA, Citrome L PMID: 28570802 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Ketamine for Depression, 2: Diagnostic and Contextual Indications.
This article examines diagnostic indications for the off-label use of ketamine as an antidepressant and possible contexts in which ketamine may be trialled. Ketamine is indicated in patients who are in a major depressive episode. Most of the research data have been collected from patients with major depressive disorder, but patients with bipolar depression have also been studied. Ketamine is effective in both diagnostic groups, but its benefits are impermanent, perhaps more so in bipolar depression. There are several contexts within this diagnostic framework when a ketamine trial may be considered. These include severe dep...
Source: Journal of Clinical Psychiatry - June 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Raloxifene Plus Antipsychotics Versus Placebo Plus Antipsychotics in Severely Ill Decompensated Postmenopausal Women With Schizophrenia or Schizoaffective Disorder: A Randomized Controlled Trial.
CONCLUSIONS: Individuals in the active treatment arm showed worse outcome than those in the placebo arm, most likely as a result of chance variation, but the results unequivocally show no benefit of antipsychotics plus raloxifene versus antipsychotics plus placebo in this large randomized, double-blind, placebo-controlled trial in postmenopausal women. These data do not support the use of raloxifene in severely decompensated schizophrenia patients until reliable research identifies what subgroup of patients or domain of outcome is benefited. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01280305. PMID: 2854...
Source: Journal of Clinical Psychiatry - May 26, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) for Hoarding Disorder in Older Adults: A Randomized Clinical Trial.
CONCLUSIONS: CREST appears to be an efficacious treatment compared to CM for older adults, but CM also showed meaningful benefits. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01227057​. PMID: 28541646 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 26, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Childhood Maltreatment and Lifetime Suicidal Behaviors Among New Soldiers in the US Army: Results From the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS).
Authors: Stein MB, Campbell-Sills L, Ursano RJ, Rosellini AJ, Colpe LJ, He F, Heeringa SG, Nock MK, Sampson NA, Schoenbaum M, Sun X, Jain S, Kessler RC, Army STARRS Collaborators Abstract OBJECTIVE: Understanding suicide risk is a priority for the US military. We aimed to estimate associations of childhood maltreatment with pre-enlistment suicidal behaviors in new Army soldiers. METHODS: Cross-sectional survey data from 38,237 soldiers reporting for basic training from April 2011 through November 2012 were analyzed. Scales assessing retrospectively reported childhood abuse and neglect were derived and subjected...
Source: Journal of Clinical Psychiatry - May 26, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Expert Consensus Survey on Medication Adherence in Psychiatric Patients and Use of a Digital Medicine System.
Authors: Hatch A, Docherty JP, Carpenter D, Ross R, Weiden PJ Abstract BACKGROUND: There is an unmet need to objectively assess adherence problems that are a common cause of unexplained or unexpected suboptimal outcome. A digital medicine system (DMS) has been developed to address this need in patients with serious mental illness. OBJECTIVE: To conduct a quantitative expert consensus survey to (1) assess relative importance of causes of suboptimal outcomes, (2) examine modalities used to assess adherence, (3) provide guidance on when and how to use the DMS in clinical practice once available, and (4) suggest in...
Source: Journal of Clinical Psychiatry - May 26, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Consensus Recommendations for the Clinical Application of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Depression.
CONCLUSIONS: Multiple randomized controlled trials and published literature have supported the safety and efficacy of rTMS antidepressant therapy. These consensus recommendations, developed by the NNDC rTMS Task Group and APA CoR Task Force on Novel Biomarkers and Treatments, provide comprehensive information for the safe and effective clinical application of rTMS in the treatment of MDD. PMID: 28541649 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 26, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Vitamin D Deficiency Associated With Cognitive Functioning in Psychotic Disorders.
Authors: Nerhus M, Berg AO, Simonsen C, Haram M, Haatveit B, Dahl SR, Gurholt TP, Bjella TD, Ueland T, Andreassen OA, Melle I Abstract BACKGROUND: Cognitive dysfunctions are core features of psychotic disorders with substantial impact on daily functioning. Vitamin D deficiency has been found to be related to cognitive dysfunctions, but the associations between vitamin D deficiency and cognition in persons with a psychotic disorder are largely unknown. METHODS: This cross-sectional study included 225 patients with a DSM-IV psychotic disorder consecutively recruited from 2003 to 2014 and 159 randomly selected hea...
Source: Journal of Clinical Psychiatry - May 13, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Technology-Assisted Parent Training Programs for Children and Adolescents With Disruptive Behaviors: A Systematic Review.
Authors: Baumel A, Pawar A, Mathur N, Kane JM, Correll CU Abstract OBJECTIVE: To systematically review digitally assisted parent training programs (DPTs) targeting the treatment of children and adolescents with disruptive behaviors. DATA SOURCES: A search was conducted using PubMed, PsycINFO, and EMBASE databases for peer-reviewed studies published between January 1, 2000, and March 1, 2016. Reference lists of included and review articles were searched manually for additional references. STUDY SELECTION: Broad search terms in varying combinations for parent, training, technologies, and disruptive behavior p...
Source: Journal of Clinical Psychiatry - May 13, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The US Food and Drug Administration's Perspective on the New Antipsychotic Pimavanserin.
CONCLUSIONS: Pimavanserin is the only FDA-approved treatment for the hallucinations and delusions seen in patients with psychosis of Parkinson's disease. Although pimavanserin appears to have a pharmacologic mechanism that is different from other atypical antipsychotics, concern remained that the increased risk of death seen with antipsychotic use in elderly demented patients, and described in all approved antipsychotic labels, would also occur with pimavanserin. Pimavanserin bears the same boxed warning about the risk of death associated with antipsychotic use in elderly patients with dementia. PMID: 28493654 [PubMed ...
Source: Journal of Clinical Psychiatry - May 13, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Development of a Computerized Adaptive Test Suicide Scale-The CAT-SS.
CONCLUSIONS: The CAT-SS is able to accurately measure the latent suicide dimension with a mean of 10 items in approximately 2 minutes. Further validation against an independent clinician-administered assessment of suicide risk (ideation and attempts) and prediction of suicidal behavior is underway. PMID: 28493655 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - May 13, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Perceived Stigma and Quality of Life in Patients Following Recovery From Delirium.
This study included 128 patients who completed a follow-up assessment after recovery from delirium. A multivariate analysis revealed that patients who had a history of depression (B = 3.34, P = .026), could recall their experiences with delirium (B = 1.71, P = .011), and had a longer duration from delirium detection to recovery (B = 1.39, P = .012) obtained higher PSDS scores than patients without these characteristics. The ability to recall delirium experiences (B = -7.17, P = .026) and the use of antipsychotics at follow-up assessment (B = -7.87, P = .039) were associated with lower EQ-VAS scores. Additionally, PSDS scor...
Source: Journal of Clinical Psychiatry - May 13, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

National Trends in Antidepressant, Benzodiazepine, and Other Sedative-Hypnotic Treatment of Older Adults in Psychiatric and Primary Care.
Authors: Maust DT, Blow FC, Wiechers IR, Kales HC, Marcus SC Abstract OBJECTIVE: To describe how use of antidepressants, benzodiazepines, and other anxiolytic/sedative-hypnotics among older adults (age ≥ 65 years) has changed over time among visits to primary care providers and psychiatrists. METHODS: Data were from the National Ambulatory Medical Care Survey (years 2003-2005 and 2010-2012), a nationally representative cross-section of outpatient physician visits. Analysis focused on visits to primary care providers (n = 14,282) and psychiatrists (n = 1,095) at which an antidepressant, benzodiazepine, or oth...
Source: Journal of Clinical Psychiatry - April 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Characteristics and Risk Factors for Suicide and Deaths Among College Students: A 23-Year Serial Prevalence Study of Data From 8.2 Million Japanese College Students.
CONCLUSIONS: Results suggest the need for a stronger support system for college students. Areas for improvement could include better advertising of mental health services, student and staff education about suicide risk factors, and mentorship and outreach programs for students in their final year of classes, those majoring in medicine, and those who have taken leaves of absence or failed classes. Accommodations at the administrative level would also be helpful for students who need to retake classes or transfer credit. PMID: 28448698 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - April 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Challenges in Testing Intranasal Ketamine in Obsessive-Compulsive Disorder.
Authors: Rodriguez CI, Lapidus KAB, Zwerling J, Levinson A, Mahnke A, Steinman SA, Kalanthroff E, Simpson HB PMID: 28448699 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - April 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Duration and Relevance of Untreated Psychiatric Disorders, 2: Nonpsychotic Psychiatric Disorders and Substance Use Disorders.
Authors: Rubio JM, Correll CU PMID: 28448700 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - April 29, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research