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Psychological Pain in Suicidality: A Meta-Analysis.
Authors: Ducasse D, Holden RR, Boyer L, Artéro S, Calati R, Guillaume S, Courtet P, Olié E Abstract OBJECTIVE: Perform a meta-analysis to quantify the association between psychological pain and current or lifetime history of suicidal ideation or suicide attempt. DATA SOURCES: Search MEDLINE, Web of Science, and PsycINFO from 1965 to 2015 for (psychache OR mental pain OR psychological pain) AND (suicid*). STUDY SELECTION: Observational case-control studies addressing the difference in psychological pain between individuals with and without current or lifetime history of suicidal ideation or sui...
Source: Journal of Clinical Psychiatry - September 7, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Risk of Suicide Attempts Among Adolescents and Young Adults With Autism Spectrum Disorder: A Nationwide Longitudinal Follow-Up Study.
Authors: Chen MH, Pan TL, Lan WH, Hsu JW, Huang KL, Su TP, Li CT, Lin WC, Wei HT, Chen TJ, Bai YM Abstract BACKGROUND: Previous studies reported a high prevalence of depression among patients with autism spectrum disorder (ASD) and suggested a relationship between ASD and suicidality. However, whether ASD independently increases the risk of attempted suicide regardless of depression has not been determined. METHODS: Using the Taiwan National Health Insurance Research Database, 5,618 adolescents aged 12-17 years and young adults aged 18-29 years with ASD (ICD-9-CM code: 299) and 22,472 age- and sex-matched contr...
Source: Journal of Clinical Psychiatry - September 7, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder.
Authors: McIntyre RS, Best MW, Bowie CR, Carmona NE, Cha DS, Lee Y, Subramaniapillai M, Mansur RB, Barry H, Baune BT, Culpepper L, Fossati P, Greer TL, Harmer C, Klag E, Lam RW, Wittchen HU, Harrison J Abstract OBJECTIVE: To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD). METHODS: Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compa...
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Introduction.
Authors: Lavretsky H PMID: 28858442 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Quality of Life, Functioning, and Depressive Symptom Severity in Older Adults With Major Depressive Disorder Treated With Citalopram in the STAR*D Study.
This study examines these outcomes before and after SSRI treatment. On the basis of prior research, we hypothesized that older adults would have worse treatment outcomes in QOL, functioning, and depressive symptom severity and that nonremitters would have worse outcomes. METHODS: A retrospective secondary data analysis was conducted from the National Institute of Mental Health-funded Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study (July 2001-September 2006). We analyzed data for 2,280 nonpsychotic adults with DSM-IV-TR-defined MDD who received citalopram monotherapy. Older adults were classified a...
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Population Approach to Guide Amisulpride Dose Adjustments in Older Patients With Alzheimer's Disease.
CONCLUSIONS: These findings argue strongly for the consideration of age- and weight-based dose adjustments in older patients with AD-related psychosis and indicate that 50 mg/d of amisulpride may be both the minimal clinically effective dose and, in those aged> 75 years, the maximally tolerated dose. PMID: 28858444 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Case Report of Biotin Treatment for Valproate-Induced Hair Loss.
Authors: Grootens KP, Hartong EGTM PMID: 28858445 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Association Between Antenatal Exposure to Selective Serotonin Reuptake Inhibitors and Autism: A Need for Further Analysis.
Authors: Shi ZY, Li YM PMID: 28858446 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Brown and Colleagues Reply.
Authors: Brown HK, Hussain-Shamsy N, Lunsky Y, Dennis CE, Vigod SN PMID: 28858447 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Severity of Binge-Eating Disorder and Its Effects on Treatment Outcome.
Authors: Dakanalis A, Clerici M PMID: 28858448 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Grilo Replies.
Authors: Grilo CM PMID: 28858449 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Ketamine for Depression, 5: Potential Pharmacokinetic and Pharmacodynamic Drug Interactions.
This article explores potential pharmacokinetic and pharmacodynamic drug interactions of relevance to the use of ketamine in depression. Sparse evidence suggests that ketamine will not induce clinically significant drug interactions except to the extent that these are predictable by its clinical actions. A small body of literature indicates that drugs that induce cytochrome P450 (CYP)2B6 and CYP3A4 will reduce exposure to ketamine and that drugs that inhibit these enzymes will increase exposure to ketamine. Common genetic polymorphisms of the CYP2B6 gene may also be associated with variations in the exposure to ketamine. H...
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Association Between Bone Mineral Density and Depressive Symptoms in a Population-Based Sample.
CONCLUSIONS: QIDS-SR₁₆ score did not significantly predict BMD in the overall DHS-2 sample. There was, however, a significant association observed in participants aged ≥ 60 years. Results suggest that diagnosis and treatment of depressive symptoms may be of clinical importance in older individuals, a subgroup at high risk for osteoporosis and fractures. PMID: 28837274 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 27, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Limited Functioning After Remission of an Anxiety Disorder as a Trait Effect Versus a Scar Effect: Results of a Longitudinal General Population Study.
We examined whether impairments in mental and physical functioning following remission are a continuation of premorbid lower functioning (trait effect), due to impairments that develop during the anxiety disorder and persist beyond recovery (scar effect), or both. METHODS: Data were derived from the Netherlands Mental Health Survey and Incidence Study-2 (NEMESIS-2), a prospective psychiatric epidemiologic study among the general population with a 3-wave design (6-year follow-up, with the study starting in 2007 and ending in 2015). DSM-IV anxiety disorders were measured with the Composite International Diagnostic Interv...
Source: Journal of Clinical Psychiatry - August 18, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Preventive Effects of Lamotrigine in Bipolar II Versus Bipolar I Disorder.
CONCLUSIONS: Although the preventive effect of lamotrigine on recurrence/relapse of mood episodes in BPI has been established in a variety of clinical studies, the present study suggests that lamotrigine may be more suitable for maintenance treatment in BPII than in BPI. PMID: 28817765 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 18, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Do You Order Pharmacogenetic Testing? Why?
Authors: Goldberg JF PMID: 28796939 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 11, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Telephone-Based Depression Care Management for Postpartum Women: A Randomized Controlled Trial.
Authors: Wisner KL, Sit DKY, McShea M, Luther JF, Eng HF, Dills JL, Moses-Kolko EL, Wisniewski SR Abstract OBJECTIVE: With a period prevalence of 21.9% in the year after birth, depression is a common complication of childbearing. We assessed the impact of telephone-delivered depression care management (DCM) on symptom levels, health service utilization, and functional status 3, 6, and 12 months postpartum. METHODS: The randomized controlled trial was conducted at the University of Pittsburgh, Pittsburgh, Pennsylvania, from March 2006 through September 2010. Women (N = 628) who screened positive for depression (...
Source: Journal of Clinical Psychiatry - August 11, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Lithium Use, but Not Valproate Use, Is Associated With a Higher Risk of Chronic Kidney Disease in Older Adults With Mental Illness.
CONCLUSIONS: Lithium is independently associated with an almost 2-fold increase in CKD risk in this community sample of older mental health service users. In the absence of clear information about certain contributing factors, such as inadequate monitoring and acute and chronic lithium level elevations, causes for this increase will need to be determined in future research. PMID: 28767208 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 4, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Preventive Effects of Suvorexant on Delirium: A Randomized Placebo-Controlled Trial.
CONCLUSIONS: Suvorexant administered nightly to elderly patients admitted for acute care may provide protection against delirium. Larger studies are needed to show the potential of suvorexant to improve the circadian core domain of delirium. TRIAL REGISTRATION: UMIN Clinical Trials Registry identifier: UMIN000015681. PMID: 28767209 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - August 4, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Cognitive Deficits in Patients With Neuropsychiatric Symptoms: A Comparative Study Between Behavioral Variant Frontotemporal Dementia and Primary Psychiatric Disorders.
Authors: Vijverberg EGB, Schouws S, Meesters PD, Verwijk E, Comijs H, Koene T, Schreuder C, Beekman A, Scheltens P, Stek M, Pijnenburg Y, Dols A Abstract OBJECTIVE: To compare neuropsychological profiles in behavioral variant frontotemporal dementia (bvFTD) with its most common primary psychiatric differential diagnoses, major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia, in older patients with active symptoms. METHODS: We included patients from different cohorts with MDD (DSM-IV-TR: 296.20-296.23, 296.30-296.33; n = 42; mean ± SD age, 72.0 ± 8.0 years; female = 57.1%) inclu...
Source: Journal of Clinical Psychiatry - July 28, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Relationships of Cerebrospinal Fluid Monoamine Metabolite Levels With Clinical Variables in Major Depressive Disorder.
Authors: Yoon HS, Hattori K, Ogawa S, Sasayama D, Ota M, Teraishi T, Kunugi H Abstract OBJECTIVE: Many studies have investigated cerebrospinal fluid (CSF) monoamine metabolite levels in depressive disorders. However, their clinical significance is still unclear. We tried to determine whether CSF monoamine metabolite levels could be a state-dependent marker for major depressive disorder (MDD) based on analyses stratified by clinical variables in a relatively large sample. METHODS: Subjects were 75 patients with MDD according to DSM-IV criteria and 87 healthy controls, matched for age, sex, and ethnicity (Japanes...
Source: Journal of Clinical Psychiatry - July 28, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Efficacy of Ziprasidone Augmentation of Escitalopram for Cognitive Symptoms of Major Depressive Disorder.
CONCLUSIONS: In the present study, ziprasidone used adjunctively with the selective serotonin reuptake inhibitor escitalopram did not demonstrate a greater efficacy for cognitive symptoms in patients with MDD compared with adjunctive placebo. Future, well-designed studies examining the role of atypical antipsychotics or other augmentation versus switch strategies for cognitive symptoms in MDD are warranted. PMID: 28749091 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 28, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Ketamine for Depression, 4: In What Dose, at What Rate, by What Route, for How Long, and at What Frequency?
CONCLUSIONS: There is likely to be a complex interaction between ketamine dose, session duration, route of administration, frequency of administration, and related practice. Until definitive studies comparing different doses, rates of administration, routes of administration, and other considerations are conducted, firm recommendations are not possible. From the point of view of clinical practicability, subcutaneous, intranasal, and oral ketamine warrant further study. If domiciliary treatment is considered, the risk of abuse must be kept in mind. PMID: 28749092 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 28, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Infant-Related Intrusive Thoughts of Harm in the Postpartum Period: A Critical Review.
CONCLUSIONS: Fifty articles were included. The prevalence of harming intrusions is up to 100% in both women with and without psychiatric disorders. Stress and cognitive misinterpretation are important keys in its appearance and severity. Literature consistently states that isolated harming intrusions contain no increased risk of violence; instead, compulsive behavior is very common. Psychoeducation is found to release a lot of distress; so might cognitive-behavioral therapy and psychotropic medications. PMID: 28742290 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 26, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Evaluating the Effect of the Changes in FDA Guidelines for Clozapine Monitoring.
CONCLUSIONS: While clozapine remains an underused medication, the new FDA monitoring guidelines are likely to substantially reduce the percentage of patients who meet criteria for clozapine-associated hematologic events requiring treatment interruption. This decrease may reduce the clinical burden of managing patients on clozapine and therefore increase the number of individuals treated with this uniquely effective medication. However, prospective studies of individuals treated under the new guidelines are needed to fully assess safety of the FDA's change. PMID: 28742291 [PubMed - as supplied by publisher] (Source: Jou...
Source: Journal of Clinical Psychiatry - July 26, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Effects of a Course of Right Unilateral Ultrabrief Pulse Electroconvulsive Therapy Combined With Venlafaxine on Insomnia Symptoms in Elderly Depressed Patients.
Authors: McCall WV, Lisanby SH, Rosenquist PB, Dooley M, Husain MM, Knapp RG, Petrides G, Rudorfer MV, Young RC, McClintock SM, Mueller M, Prudic J, Greenberg RM, Weiner RD, Bailine SH, Riley MA, McCloud L, Kellner CH, CORE/PRIDE Work Group Abstract OBJECTIVE: Antidepressant medications have a variety of effects on sleep, apart from their antidepressant effects. It is unknown whether electroconvulsive therapy (ECT) has effects on perceived sleep in depressed patients. This secondary analysis examines the effects of ECT on perceived sleep, separate from its antidepressant effects. METHODS: Elderly patients with ...
Source: Journal of Clinical Psychiatry - July 26, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Insurance Coverage and Health Outcomes in Young Adults With Mental Illness Following the Affordable Care Act Dependent Coverage Expansion.
We examined the impact of the 2010 dependent coverage expansion on insurance coverage and health outcomes among young adults with mental illness. METHODS: Data are from the 2008-2013 National Survey on Drug Use and Health, an annual population-based survey of noninstitutionalized US individuals aged 12 and older. We used a difference-in-differences approach to compare young adults with mental illness subject to the provision (aged 19-25 years, n = 19,051) with an older comparison group (aged 26-34 years, n = 7,958) before (2008-2009) and after (2011-2013) the dependent coverage expansion in their insurance coverage, us...
Source: Journal of Clinical Psychiatry - July 15, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

The Health-Promoting Effects of Insurance Coverage.
Authors: Oquendo MA PMID: 28703948 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 15, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Psychotherapy Alone and Combined With Medication as Treatments for Bipolar II Depression: A Randomized Controlled Trial.
CONCLUSIONS: IPSRT plus quetiapine resulted in greater symptomatic improvement but also more side effects than IPSRT alone. A subset of participants improved with IPSRT alone, although absence of an inactive comparator limits interpretation of this finding. Receipt of preferred treatment was associated with better outcomes. Harms, benefits, and preferences should be considered when recommending treatments for BP-II depression. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01133821. PMID: 28703949 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 15, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Randomized Controlled Trial of Web-Based Psychoeducation for Women With Borderline Personality Disorder.
CONCLUSIONS: Taken together, these results suggest that internet-based psychoeducation is an effective form of early treatment for reducing the symptom severity of borderline personality disorder for periods up to 1 year. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01719731. PMID: 28703950 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 15, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Secondary Prevention of Chronic PTSD by Early and Short-Term Administration of Escitalopram: A Prospective Randomized, Placebo-Controlled, Double-Blind Trial.
CONCLUSIONS: Early and short-term administration of escitalopram was not shown to prevent PTSD, although it did improve sleep quality. In a subgroup of participants who experienced intentional trauma, however, this early-treatment approach may be effective as secondary prevention. This large study is the first to investigate the preventive effect of early administration of escitalopram on PTSD. It highlights the relevance of the type of trauma (intentional vs unintentional) to the outcome. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00300313​. PMID: 28703951 [PubMed - as supplied by publisher] (Source: ...
Source: Journal of Clinical Psychiatry - July 15, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Antipsychotic Medication Treatment Patterns in Adult Depression.
CONCLUSION: Antipsychotic medications are used in approximately 1 in 7 patients with a new episode of depression. For 1 in 12 patients, the antipsychotic was considered to be intended for nonpsychotic depression. Almost three-quarters of these patients did not receive minimally adequate treatment with antidepressants prior to antipsychotic initiation. This pattern suggests potentially inappropriate and premature initiation of a drug class with substantial adverse effects and medical risks. PMID: 28686818 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Differential Risk of Increasing Psychotropic Polypharmacy Use in Children Diagnosed With ADHD as Preschoolers.
CONCLUSIONS: Psychotropic polypharmacy, antipsychotic, and anticonvulsant use increased with each year of follow-up. This effect was strongly mediated by the age of ADHD diagnosis with substantial increases in preschoolers but no corresponding effect in older children. It was only partially explained by physician diagnoses of concomitant mental disorders. PMID: 28686819 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Cannabis Use and Cannabis Use Disorders Among Youth in the United States, 2002-2014.
This study used data from 288,300 persons aged 12-17 years who participated in the 2002-2014 National Survey on Drug Use and Health. Descriptive analyses and bivariable and multivariable logistic regressions were applied (using the year 2002 as the reference group for most analyses). RESULTS: The prevalence of past-year CU among youth decreased from 15.8% in 2002 to 13.1% in 2014 (this downward trend occurred during 2002-2007 only [β = -0.0540, P
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Gauging the Use of Second-Generation Antipsychotics: Medicaid Benefits Data Suggest Much Room for Improvement.
Authors: Thase ME PMID: 28686821 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Mindfulness-Based Stress Reduction for Older Adults With Stress Disorders and Neurocognitive Difficulties: A Randomized Controlled Trial.
CONCLUSIONS: In this population of older adults with stress disorders and neurocognitive difficulties, a mindfulness intervention improves clinical outcomes such as excessive worry and depression and may include some forms of immediate memory performance. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01693874. PMID: 28686822 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Enhancing Extinction Learning in Posttraumatic Stress Disorder With Brief Daily Imaginal Exposure and Methylene Blue: A Randomized Controlled Trial.
CONCLUSIONS: The findings provide preliminary efficacy for a brief IE treatment for PTSD and point to the potential utility of MB for enhancing outcome. Brief interventions and better tailoring of MB augmentation strategies, adjusting for observed patterns, may have the potential to reduce dropout, accelerate change, and improve outcomes. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01188694. PMID: 28686823 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 9, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research.
CONCLUSIONS: S-adenosylmethionine holds promise as a treatment for multiple neuropsychiatric conditions, but the body of evidence has limitations. The encouraging findings support further study of SAMe in both psychiatric and comorbid medical illnesses. PMID: 28682528 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Risk of Irritability With Psychostimulant Treatment in Children With ADHD: A Meta-Analysis.
CONCLUSIONS: This meta-analysis suggests an increased risk of irritability may be confined to amphetamine-derived psychostimulants. Future meta-analyses examining the effects of amphetamine and methylphenidate derivatives on irritability as a continuous measure, as well as head-to-head trials between methylphenidate and amphetamine derivatives examining effects on irritability, will be important to replicate the findings of this meta-analysis. PMID: 28682529 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Acute Substance Use as a Warning Sign for Suicide Attempts: A Case-Crossover Examination of the 48 Hours Prior to a Recent Suicide Attempt.
CONCLUSIONS: Findings suggest the importance of considering acute alcohol use and use of CNS depressants, and the concurrent use of both substances, when evaluating short-term risk for suicide attempts in clinical settings. PMID: 28682530 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Florida Best Practice Psychotherapeutic Medication Guidelines for Adults With Major Depressive Disorder.
CONCLUSIONS: The updated 2015 FPG provide concise, pragmatic, evidence-based decision support for treatment selection and sequencing for adults with MDD. Principles of practice include measurement-based care, priority to both psychiatric and medical comorbidity, identification of DSM-5-defined specifiers (eg, mixed features), suicide risk assessment, and evaluation of cognitive symptoms. The FPG have purposefully aimed to minimize emphasis on "expert opinion" and instead differentially emphasized extant evidence for pharmacologic treatments. PMID: 28682531 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Introduction: Identifying the Patients Most at Risk for Suicide Beyond Suicidal Ideation.
Authors: Courtet P PMID: 28682532 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Assessment of Suicidal Ideation and Behavior: Report of the International Society for CNS Clinical Trials and Methodology Consensus Meeting.
CONCLUSIONS: All 5 working groups agreed that a major barrier to advancement of the field of SI/SB research and the development of new treatments for SI/SB remains the lack of a universally accepted standardized nomenclature and classification system. Achieving alignment on definitions and classification of suicide-related phenomena is critical to improving the detection and assessment of SI/SB, the design of clinical trials for new treatments, and effective public health interventions. PMID: 28682533 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Objectively Assessed Sleep Variability as an Acute Warning Sign of Suicidal Ideation in a Longitudinal Evaluation of Young Adults at High Suicide Risk.
Authors: Bernert RA, Hom MA, Iwata NG, Joiner TE Abstract OBJECTIVE: Young adults attempt suicide at disproportionately high rates relative to other groups and demonstrate high rates of sleep disturbance. No study has yet prospectively evaluated disturbed sleep as an acute indicator of risk using an objective index of sleep. We investigated objective and subjective parameters of disturbed sleep as a warning sign of suicidal ideation among young adults over an acute period. METHODS: A longitudinal study across a 21-day observation period and 3 time points. Fifty of 4,847 participants (aged 18-23 years) were pres...
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Low Nitric Oxide and High C-Reactive Protein in Depression: Not a Paradox!
Authors: Oxenkrug G PMID: 28682535 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Ketamine for Depression, 3: Does Chirality Matter?
This article examines preclinical and clinical literature on the antidepressant properties of S-ketamine. Animal data suggest potential advantages for R-ketamine over S-ketamine. Case reports, case series, and some small randomized controlled trials suggest that single or repeated intravenous infusions (0.2-0.4 mg/kg) or intranasal administrations (28-84 mg) of S-ketamine have antidepressant action in patients with medication-refractory depression and that the observed benefits are similar in magnitude to the antidepressant benefits reported with racemic ketamine. However, there are no direct comparisons between S-ketamine...
Source: Journal of Clinical Psychiatry - July 8, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Independent Effects of Apolipoprotein E and Cerebrovascular Burden on Later-Life Depression: The Wisconsin Longitudinal Study.
CONCLUSIONS: The present findings suggest that APOE may influence expression of depressive symptomatology as adults age into and beyond their mid-70s but do not indicate APOE as a moderator of vascular depression. Results posit a potential explanation for inconsistent past findings. PMID: 28640987 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 25, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Does Half-Life Matter After Antipsychotic Discontinuation? A Relapse Comparison in Schizophrenia With 3 Different Formulations of Paliperidone.
Authors: Weiden PJ, Kim E, Bermak J, Turkoz I, Gopal S, Berwaerts J Abstract OBJECTIVE: To evaluate the effect of 1 oral and 2 distinct long-acting injectable (LAI) formulations of the same antipsychotic on times to relapse following medication discontinuation. METHODS: Data were drawn from 3 similarly designed, multicenter, double-blind, placebo-controlled, randomized-withdrawal studies of paliperidone in adults with a schizophrenia diagnosis (according to DSM-IV criteria for ≥ 1 year before screening): once-daily extended-release oral paliperidone (ORAL paliperidone), once-monthly paliperidone palmitate (P...
Source: Journal of Clinical Psychiatry - June 25, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Stimulant Treatment Trajectories Are Associated With Neural Reward Processing in Attention-Deficit/Hyperactivity Disorder.
Authors: Schweren LJS, Groenman A, von Rhein D, Weeda W, Faraone SF, Luman M, van Ewijk H, Heslenfeld DJ, Franke B, Buitelaar JK, Oosterlaan J, Hoekstra PJ, Hartman CA Abstract OBJECTIVE: The past decades have seen a surge in stimulant prescriptions for the treatment of attention-deficit/hyperactivity disorder (ADHD). Stimulants acutely alleviate symptoms and cognitive deficits associated with ADHD by modulating striatal dopamine neurotransmission and induce therapeutic changes in brain activation patterns. Long-term functional changes after treatment are unknown, as long-term studies are scarce and have focused on...
Source: Journal of Clinical Psychiatry - June 25, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Opiate Antagonists Do Not Interfere With the Clinical Benefits of Stimulants in ADHD: A Double-Blind, Placebo-Controlled Trial of the Mixed Opioid Receptor Antagonist Naltrexone.
CONCLUSIONS: Our findings provide support for the concept of combining opioid receptor antagonists with stimulants to provide an effective stimulant formulation with less abuse potential. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01673594​. PMID: 28640990 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - June 25, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research