Baclofen, a French Exception, Seriously Harms Alcohol Use Disorder Patients Without Benefit.
Authors: Braillon A, Naudet F PMID: 33434955 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 14, 2021 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Citalopram for Acute and Preventive Efficacy in Bipolar Depression (CAPE-BD): A Randomized, Double-Blind, Placebo-Controlled Trial.
CONCLUSIONS: Citalopram, added to standard mood stabilizers, did not have clinically meaningful benefit versus placebo for either acute or maintenance treatment of bipolar depression. Acute mania did not worsen with citalopram, but maintenance treatment led to worsened manic symptoms, especially in subjects with a rapid-cycling course. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00562861. PMID: 33434956 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 14, 2021 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

How Much Is the Debate Over Antidepressant Efficacy and Safety in Bipolar Depression an Artifact of Study Methodologies?
Authors: Goldberg JF PMID: 33434957 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 14, 2021 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Effects of Long-Acting Injectable Paliperidone Palmitate on Clinical and Functional Outcomes in Patients With Schizophrenia Based on Illness Duration.
This study aimed to examine the degree of clinical and functional improvement after paliperidone long-acting injectable (LAI) administration according to the duration of illness. METHODS: Patients with schizophrenia diagnosed by ICD-10 criteria who were planned to start once-monthly paliperidone LAI were recruited from 2010 to 2017. Clinical and functional changes were measured every 4 weeks using the Clinical Global Impressions-Severity of Illness scale (CGI-S) and Personal and Social Performance scale (PSP), respectively, for 6 months after paliperidone LAI initiation. Improvements after starting paliperidone LAI wer...
Source: Journal of Clinical Psychiatry - January 14, 2021 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Optimal Long-Acting Injectable Antipsychotic Management During COVID-19.
Authors: MacLaurin SA, Mulligan C, Van Alphen MU, Freudenreich O PMID: 33434959 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 14, 2021 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Andrade Replies.
Authors: Andrade C PMID: 33434960 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 14, 2021 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Associations Between ADHD Medication Use in Pregnancy and Severe Malformations Based on Prenatal and Postnatal Diagnoses: A Danish Registry-Based Study.
CONCLUSIONS: Exposure to methylphenidate was not associated with an increased risk of malformations overall in data that included information from both prenatal and postnatal diagnoses of major malformations. There was an increased risk of cardiac malformations with NNH of 92 based on 12 cases among the exposed. More data are needed on other types of ADHD medication. PMID: 33406323 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - January 7, 2021 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Prevalence and Correlates of Caregiver-Reported Mental Health Conditions in Youth With Autism Spectrum Disorder in the United States.
CONCLUSIONS: Caregiver-reported MHCs are prevalent in children with ASD in the US from a young age and characterize> 85% by adolescence. There is an outsized need for effective MHC assessment and treatment of these youth that demands expedient innovation in both MHC and developmental disability policy and practice. PMID: 33356021 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 30, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Common and Country-Specific Characteristics Associated With Suicidality in the Arab Region.
Authors: Daouk S, Awaad R, Ahmed B, Barakat S, Muñoz RF, Leykin Y Abstract OBJECTIVE: To explore the prevalence of recent (previous 2 weeks) suicide attempts and estimates of likelihood of future suicide attempts as well as demographic characteristics associated with such attempts among residents of the Arab region looking for depression information online. METHODS: Google Ads were used to recruit 1,003 Arabic-speaking adults mostly from February 2014 to June 2014 to take part in a depression and suicidality screening study using a self-report questionnaire based on DSM-IV diagnostic criteria. RESULT...
Source: Journal of Clinical Psychiatry - December 30, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Toward Targeted ECT: The Interdependence of Predictors of Treatment Response in Depression Further Explained.
Authors: van Diermen L, Poljac E, Van der Mast R, Plasmans K, Van den Ameele S, Heijnen W, Birkenhäger T, Schrijvers D, Kamperman A Abstract OBJECTIVE: Several clinical variables assumed to be predictive of electroconvulsive therapy (ECT) outcome in major depressive disorder show substantial interrelations. The current study tries to disentangle this interdependence to distill the most important predictors of treatment success to help improve patient-treatment matching. METHODS: We constructed a conceptual framework of interdependence capturing age, episode duration, and treatment resistance, all variables...
Source: Journal of Clinical Psychiatry - December 18, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Efficacy and Safety of HP-3070, an Asenapine Transdermal System, in Patients With Schizophrenia: A Phase 3, Randomized, Placebo-Controlled Study.
Authors: Citrome L, Walling DP, Zeni CM, Starling BR, Terahara T, Kuriki M, Park AS, Komaroff M Abstract OBJECTIVE: Asenapine is a second-generation antipsychotic used to treat individuals with schizophrenia. This phase 3 study assessed efficacy and safety of HP-3070, an asenapine transdermal system (patch), in adults with schizophrenia. METHODS: In this inpatient study, a 3- to 14-day screening/single-blind run-in washout period was followed by a 6-week double-blind period wherein patients with acutely exacerbated schizophrenia (DSM-5 criteria) were randomized 1:1:1 and received HP-3070 7.6 mg/24 h (n = 204), ...
Source: Journal of Clinical Psychiatry - December 18, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Antipsychotic Medication Prescriptions for Homeless and Unstably Housed Veterans in the Veterans Affairs Health Care System.
Authors: Tsai J, Szymkowiak D, Radhakrishnan R Abstract OBJECTIVE: Many homeless and unstably housed (HUH) adults have severe mental illnesses that are managed with antipsychotic medications. The US Department of Veterans Affairs (VA) is the largest provider of homeless services, but there has been little study of psychotropic medication prescriptions for HUH veterans. METHODS: Using national VA administrative data in 2017, rates and characteristics associated with prescriptions for antipsychotic medications for veterans using VA health care services (N = 2,882,993), including HUH veterans (n = 266,855), were a...
Source: Journal of Clinical Psychiatry - December 11, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Is COVID-19 Associated With Posttraumatic Stress Disorder?
CONCLUSIONS: The prevalence of PTSD in patients with COVID-19 is not as high as that reported among patients during previous epidemics. Initial psychological responses were predictive of a PTSD diagnosis, even though most patients showing acute psychological distress (33.5% of the sample) improved in the following weeks. PTSD symptoms also increased following a stay in an intensive care unit. Future studies should assess the long-term consequences of COVID-19 on patients' mental health. PMID: 33296149 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 11, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Interest-Activity Dimension and Response to Aripiprazole.
Authors: Swami MK, Mishra VC PMID: 33296150 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 11, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Uher and Colleagues Reply.
Authors: Uher R, Lam RW, Kennedy SH PMID: 33296151 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 11, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Paternal Depression as a Risk Factor for Neurodevelopmental Disorders in Offspring: Implications for Maternal Depression and Its Treatment During Pregnancy.
Authors: Andrade C Abstract Many but not all studies suggest that gestational exposure to antidepressant drugs is associated with an increased risk of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in offspring. All of these studies have been observational in design, and observational research may suggest but cannot establish cause-effect relationships. In this context, a recent, large, population-based, observational study found that exposure to maternal depression before, during, or after pregnancy was each associated with an increased risk of ASD as well as ADHD. Strikingly, t...
Source: Journal of Clinical Psychiatry - December 4, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Effect of Adjunctive Pimavanserin on Sleep/Wakefulness in Patients With Major Depressive Disorder: Secondary Analysis From CLARITY.
Authors: Jha MK, Fava M, Freeman MP, Thase ME, Papakostas GI, Shelton RC, Trivedi MH, Dirks B, Liu K, Stankovic S Abstract OBJECTIVE: This was an analysis of the effect of pimavanserin, a 5-hydroxytryptamine-2A antagonist and inverse receptor agonist, on dysregulated sleep in patients with major depressive disorder (MDD) by DSM-5 criteria and an inadequate antidepressant response. METHODS: For this analysis of CLARITY, a phase 2 study of adjunctive pimavanserin (N = 207) conducted between December 2016 and October 2018, sleep/wakefulness disturbances were measured with the 17-item Hamilton Depression Rating Sca...
Source: Journal of Clinical Psychiatry - December 4, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Sexual Orientation, Adverse Childhood Experiences, and Comorbid DSM-5 Substance Use and Mental Health Disorders.
CONCLUSIONS: Sexual minorities are exposed to more ACEs than their heterosexual counterparts in the US. We found evidence that US sexual minorities are at higher risk of comorbid substance use and mental health disorders. These findings reinforce the importance of identifying exposure to ACEs and developing trauma-informed interventions to treat comorbidities in those exposed to multiple ACEs, especially sexual minorities.​. PMID: 33264820 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 4, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Diagnosing Dementia-Related Psychosis: Using Tools and Communicating With Patients and Caregivers.
Authors: Ballard C Abstract ​​​​​​ Psychosis is common in patients with dementia; therefore, clinicians should carefully evaluate psychotic symptoms reported by patients or their caregivers. A variety of tools exist for the diagnosis of DRP, such as the Neuropsychiatric Inventory and new diagnostic criteria. It is important to talk with patients and caregivers about the impact of DRP on well-being, their level of distress (and patients' insight), the potential risks of medication to treat DRP, and the potential course of DRP because, then, it is possible for people to contribute knowledgably to discussi...
Source: Journal of Clinical Psychiatry - December 4, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

How to Evaluate Patients for Tardive Dyskinesia.
Authors: Nierenberg AA Abstract ​​​​​​​​ Tardive dyskinesia (TD) is a serious and potentially irreversible movement disorder that occurs in 20%-50% of patients taking antipsychotic drugs. TD is also associated with several other classes of medications, including antidepressants, antihistamines, decongestants, mood stabilizers, and stimulants. As more people are prescribed medications that can increase the risk for TD, it is important that clinicians learn how to systematically and reasonably evaluate their patients for this potentially dangerous and debilitating condition. PMID: 33264822 [PubMed...
Source: Journal of Clinical Psychiatry - December 4, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Pharmacology and Evidence-Based Strategies for Current and Emerging Treatments for OFF Periods in Parkinson Disease.
Authors: Pahwa R, Isaacson SH Abstract ​​​​​​​​ Parkinson disease (PD) is a progressive neurodegenerative disease characterized by motor symptoms such as rigidity, resting tremor, and slowed movement in addition to nonmotor symptoms. As the disease advances and a patient's response duration to a levodopa dose is shortened, OFF episodes become more prevalent, negatively impacting their quality of life. Clinicians may employ a variety of therapeutic strategies to reduce OFF time, such as altering the levodopa dose or initiating adjuvant therapy. Medications to treat daily OFF time include dopamine ago...
Source: Journal of Clinical Psychiatry - December 4, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Recognizing and Treating Excessive Daytime Sleepiness in Patients With Narcolepsy.
Authors: Roth T, Winkelman JW Abstract Sleep disorders such as narcolepsy can cause excessive daytime sleepiness (EDS). The diagnosis of narcolepsy is often delayed by years. Clinicians can improve the recognition of EDS and diagnosis of sleep disorders using screening tools such as the Epworth Sleepiness Scale and other tests. By following up with patients who present with EDS and continuing to assess until a cause is found, clinicians can lessen the time to diagnosis and initiate appropriate treatment. Fortunately, existing pharmacologic interventions are effective in reducing EDS for many patients, but eliminati...
Source: Journal of Clinical Psychiatry - November 27, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Gabapentin for Alcohol-Related Disorders: Critical Appraisal of the Symptom-Driven Approach.
Authors: Andrade C Abstract Gabapentin, available as gabapentin and as the prodrug gabapentin enacarbil, is an approved treatment for partial seizures, postherpetic neuralgia, and the restless legs syndrome. Gabapentin has been studied for diverse off-label indications, including alcohol use disorder (AUD). Meta-analyses of randomized controlled trials (RCTs) suggest that gabapentin reduces the severity of alcohol withdrawal symptoms (AWS) as well as the percentage of heavy drinking days in persons with AUD; however, the magnitude of benefit is small, and no benefits are apparent for other drinking outcomes. Furthe...
Source: Journal of Clinical Psychiatry - November 27, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Outcomes of Neuroleptic Malignant Syndrome With Depot Versus Oral Antipsychotics: A Systematic Review and Pooled, Patient-Level Analysis of 662 Case Reports.
CONCLUSIONS: These data, plus the fact that only 10 published NMS cases exist with SGA-LAIs, should mitigate safety concerns regarding LAIs, but results should be interpreted cautiously since they are based on case reports. PMID: 33238083 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 27, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Long-Acting Injectable Antipsychotic Use During Pregnancy: A Brief Review and Concise Guide for Clinicians.
Authors: Reinstein SA, Cosgrove J, Malekshahi T, Deligiannidis KM PMID: 33238084 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 27, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Dr Manu Replies.
Authors: Manu P PMID: 33211909 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

An Association Between the Inflammatory Biomarker GlycA and Depressive Symptom Severity.
CONCLUSIONS: This study found a positive association between the inflammatory biomarker GlycA, but not hs-CRP, and depressive symptom severity in a large multiethnic and multiracial community-based sample. Thus, these results provide the first indication that GlycA may be a potentially useful novel biomarker of depression. PMID: 33211910 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Sudden Death in Psychiatric Patients Is Multifactorial.
Authors: Finsterer J, Fiorini AC, Scorza CA, Scorza FA PMID: 33211911 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Cost-Effectiveness of Routine Screening for Autoimmune Encephalitis in Patients With First-Episode Psychosis in the United States.
CONCLUSIONS: Routine screening for AE in patients with FEP may be cost-effective in the United States. As further immunotherapy effectiveness data become available, a more definitive recommendation to perform routine screening could be warranted. PMID: 33211912 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 21, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Happiness During Low-Dose Ketamine Infusion Predicts Treatment Response: Reexploring the Adjunctive Ketamine Study of Taiwanese Patients With Treatment-Resistant Depression.
CONCLUSIONS: Subjective happiness during ketamine infusion predicted the antidepressant effect of both 0.5 mg/kg and 0.2 mg/kg ketamine infusion over time. Happiness during ketamine infusion, which was not related to the psychotomimetic effect of ketamine, may be associated with the reduction of depressive symptoms during the follow-up. TRIAL REGISTRATION: UMIN Clinical Trials Registry registration number: UMIN000016985. PMID: 33176071 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Predictors of Loneliness by Age Decade: Study of Psychological and Environmental Factors in 2,843 Community-Dwelling Americans Aged 20-69 Years.
Authors: Nguyen TT, Lee EE, Daly RE, Wu TC, Tang Y, Tu X, Van Patten R, Jeste DV, Palmer BW Abstract OBJECTIVE: Loneliness is a prevalent and serious public health problem due to its effects on health, well-being, and longevity. Understanding correlates of loneliness is critical for guiding efforts toward the development of evidence-based strategies for prevention and intervention. Considering that patterns of association between age and loneliness vary, the present study sought to examine age-related differences in risk and protective factors for loneliness. METHODS: Correlates of loneliness were examined thro...
Source: Journal of Clinical Psychiatry - November 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Happiness and Treatment Outcome in Resistant Depression.
Authors: Papakostas GI PMID: 33176073 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Proof-of-Concept Study of Subanesthetic Intravenous Ketamine Combined With Prolonged Exposure Therapy Among Veterans With Posttraumatic Stress Disorder.
Authors: Shiroma PR, Thuras P, Wels J, Erbes C, Kehle-Forbes S, Polusny M PMID: 33176074 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 13, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Predictors of Bipolar Disorder Versus Schizophrenia Diagnosis in a Multicenter First Psychotic Episode Cohort: Baseline Characterization and a 12-Month Follow-Up Analysis.
Authors: Salagre E, Grande I, Vieta E, Mezquida G, Cuesta MJ, Moreno C, Bioque M, Lobo A, González-Pinto A, Moreno DM, Corripio I, Verdolini N, Castro-Fornieles J, Mané A, Pinzon-Espinosa J, Bonnin CDM, Bernardo M, Group P Abstract OBJECTIVE: The aim of this study was to identify predisposing factors and clinical features at baseline that might help predict diagnosis of bipolar disorder vs schizophrenia in a first-episode psychosis (FEP) cohort. METHODS: In this prospective, naturalistic study, we evaluated a cohort of 335 subjects with FEP recruited from April 2009 to April 2012. Baseline feature...
Source: Journal of Clinical Psychiatry - November 5, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Differences in Prescription Stimulant Misuse Motives Across Adolescents and Young Adults in the United States.
This study examined a number of PSM motives across the AYA age spectrum using the 2015-2018 National Survey on Drug Use and Health. METHODS: In all, 86,918 AYAs (aged 14-25 years) were included. Individual PSM motives (eg, to study) and motive categories (ie, cognitive enhancement only, recreational only, weight loss only, and combined motives) were examined by age. Logistic regression models examined links between individual motives or motive categories and educational status, substance use, DSM-IV substance use disorders (SUD), and mental health correlates. RESULTS: Significant differences were found across AYAs ...
Source: Journal of Clinical Psychiatry - November 5, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Collaborating With Patients to Make Treatment Decisions Based on Benefits and Risks of Medications Associated With Tardive Dyskinesia.
Authors: Nierenberg AA Abstract ​​​​​​ Many patients who are at risk for tardive dyskinesia fear that they might develop the involuntary neurological movement disorder, yet it is possible for clinicians to convey a realistic assessment of the benefits and risks of medications that might induce TD. Clinicians need to be aware of the importance of communicating reasonable risk in a way that will not alarm patients, using tools such as probabilities and phronesis in discussions with their patients. PMID: 33147657 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

How to Assess Tardive Dyskinesia Symptom Improvement With Measurement-Based Care.
Authors: McEvoy JP Abstract ​​​​​​ Clinicians now have 2 effective and well-tolerated vesicular monoamine transporter 2 (VMAT2) inhibitors-valbenazine and deutetrabenazine-for the treatment of patients with tardive dyskinesia (TD), a severe and potentially irreversible side effect associated with dopamine receptor blocking agents. Clinicians should use measurement-based care, eg, the Abnormal Involuntary Movement Scale with activation maneuvers, to assess and document TD symptoms and treatment progress. Each follow-up visit should be personalized with questions related to patients' functioning and level...
Source: Journal of Clinical Psychiatry - November 5, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Impact of Dementia-Related Psychosis on Patients and Caregivers: The Treatment Imperative.
This report reviews the impact of DRP on patients and carers, assessment tools, and coping strategies and techniques to help care partners manage DRP. PMID: 33147659 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Randomized Controlled Trial of Riluzole Augmentation for Posttraumatic Stress Disorder: Efficacy of a Glutamatergic Modulator for Antidepressant-Resistant Symptoms.
CONCLUSIONS: Although preliminary, the exploratory findings of this study offer some evidence that riluzole augmentation of an SSRI or SNRI may selectively improve PTSD hyperarousal symptoms without changes in overall PTSD symptoms, depression, anxiety, or disability. Additional investigation of the mechanism of the efficacy of riluzole for hyperarousal symptoms is warranted. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02155829. PMID: 33113596 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 29, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Sex Differences in the Longitudinal Course and Outcome of Bipolar Disorder in Youth.
Authors: Mitchell RHB, Hower H, Birmaher B, Strober M, Merranko J, Rooks B, Goldstein TR, Hunt JI, Dickstein DP, Diler RS, Ryan ND, Gill MK, Axelson D, Keller MB, Yen S, Goldstein BI Abstract OBJECTIVE: Despite substantial literature on sex differences in adults with bipolar disorder (BD), little is known about this topic in youth; this study examines sex differences in mood symptomatology and psychiatric comorbidity in prospectively followed youth with BD. METHODS: A subsample of the Course and Outcome of Bipolar Youth study (N = 370; female n = 199, male n = 171) enrolled October 2000-July 2006 (age at intake...
Source: Journal of Clinical Psychiatry - October 29, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Pathophysiology, Patient Burden, and Recognition of OFF Episodes of Parkinson Disease.
Authors: Pahwa R, Isaacson SH Abstract ​​​​ The pathophysiology of PD has been elusive, but the motor symptoms of the disease are believed to result from a dopamine deficiency in the substantia nigra. As a patient's disease progresses, OFF episodes emerge due to a shorter duration of response to levodopa treatment. OFF episodes include both motor and nonmotor symptoms, are common, and can occur at any time. OFF episodes can be predictable or unpredictable, significantly impact patient quality of life and functionality, and place a burden on families. By facilitating communication with patients and care part...
Source: Journal of Clinical Psychiatry - October 29, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

A Randomized, Placebo-Controlled Trial of Mirtazapine for the Treatment of Posttraumatic Stress Disorder in Veterans.
CONCLUSIONS: This study did not show efficacy of mirtazapine monotherapy in the treatment of PTSD. Identification of more effective treatments, either as monotherapy or adjunctive, for PTSD is imperative. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT00302107. PMID: 33084254 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 22, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Psychological and Coping Responses of Health Care Workers Toward Emerging Infectious Disease Outbreaks: A Rapid Review and Practical Implications for the COVID-19 Pandemic.
CONCLUSIONS: Psychological support for HCW in the current COVID-19 pandemic and future outbreaks should focus on both individual (eg, psychoeducation on possible psychological responses, self-care) and institutional (eg, clear communication, providing access to resources for help, recognition of efforts of HCW) measures. PMID: 33084255 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 22, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Frederick K. Goodwin, MD 1936-2020.
Authors: Ghaemi SN PMID: 33049803 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 15, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Evaluation of the Effect of SPN-812 (Viloxazine Extended-Release) on QTc Interval in Healthy Adults.
CONCLUSIONS: This study demonstrated that SPN-812 had no effect on cardiac repolarization or other ECG parameters in healthy adults, suggesting that it is not associated with a risk for cardiac arrhythmias or other electrocardiographic parameters. PMID: 33049804 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 15, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Comparing Medications for DSM-5 PTSD in Routine VA Practice.
Authors: Shiner B, Leonard CE, Gui J, Cornelius SL, Schnurr PP, Hoyt JE, Young-Xu Y, Watts BV Abstract OBJECTIVE: Fluoxetine, paroxetine, sertraline, topiramate, and venlafaxine have previously shown efficacy for posttraumatic stress disorder (PTSD). One prior study using US Department of Veterans Affairs (VA) medical records data to compare these agents found no differences in symptom reduction in clinical practice. The current study addresses several weaknesses in that study, including limited standardization of treatment duration, inability to account for prior treatment receipt, use of an outdated symptomatic a...
Source: Journal of Clinical Psychiatry - October 15, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Real-World Preventive Effects of Suvorexant in Intensive Care Delirium: A Retrospective Cohort Study.
CONCLUSIONS: The present study extends to real-world settings previous findings that suvorexant is effective for delirium prevention. PMID: 33027560 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 9, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Prevalence of Passive Suicidal Ideation in the Early Stage of the Coronavirus Disease 2019 (COVID-19) Pandemic and Lockdown in a Large Spanish Sample.
Authors: Sáiz PA, de la Fuente-Tomas L, García-Alvarez L, Bobes-Bascarán MT, Moya-Lacasa C, García-Portilla MP, Bobes J PMID: 33027561 [PubMed - in process] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 9, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Understanding the Basics of Meta-Analysis and How to Read a Forest Plot: As Simple as It Gets.
This article explains why meta-analysis may be necessary, how a systematic review is conducted to identify studies for meta-analysis, and how to interpret the various elements in a forest plot. Brief discussions are provided about important concepts relevant to meta-analysis, including heterogeneity, subgroup analyses, sensitivity analyses, fixed effect and random effects meta-analyses, and the detection of publication bias. Other procedures briefly explained include meta-regression analysis, pooled analysis, individual participant data meta-analysis, and network meta-analysis. The limitations of meta-analysis are also dis...
Source: Journal of Clinical Psychiatry - October 9, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Impact of Pandemic on Suicide: Excess Suicides in Taiwan During the 1918-1920 Influenza Pandemic.
Authors: Chang YH, Chang SS, Hsu CY, Gunnell D PMID: 32991791 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 30, 2020 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research