Physical Exercise and Health, 1: An Overview of Terminology, Guidance, Benefits, and Risks
This article outlines the magnitude of the global problem. It discusses terms such as physical activity, aerobic exercise, muscle strengthening exercise, weight-bearing exercise, sitting time, and sedentariness. It presents and explains current guidance on physical activity, averaged across a week, for adults as well as special populations, including adolescents, the elderly, and pregnant women. It notes that immediate, short-term, and long-term benefits of exercise have been identified in thousands of randomized controlled trials (RCTs) and cohort studies, and pooled in hundreds of meta-analyses, for a wide range of neuro...
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

Lemborexant and Daridorexant for the Treatment of Insomnia: An Indirect Comparison Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed
Conclusions: In Phase 3 trials, the benefit-risk ratios for both lemborexant and daridorexant were favorable as measured by NNT, NNH, and LHH. Indirect comparisons of lemborexant with daridorexant suggest an efficacy advantage for lemborexant and a tolerability advantage for daridorexant.Clinical Trials Registration: NCT02783729, NCT02952820, NCT03545191, NCT03575104.PMID:37796657 | DOI:10.4088/JCP.23m14851 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Leslie Citrome Timothy R Juday Christie Lundwall Source Type: research

Exploratory Analysis of the Effects of Celecoxib on Cognitive Function in Vortioxetine-Treated Patients With Major Depressive Disorder in the PREDDICT Study: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Conclusions: Both treatment groups showed a reduction in depression-associated cognitive impairment. No superior clinical effect was reported for the add-on celecoxib group. HsCRP was modulated by neither vortioxetine nor add-on celecoxib.Trial Registration: ANZCTR identifier: ACTRN12617000527369.PMID:37796652 | DOI:10.4088/JCP.23m14829 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Emma Sampson Natalie T Mills Hikaru Hori Kathrin Schwarte Christa Hohoff Oliver Schubert Scott R Clark C élia Fourrier Bernhard T Baune Source Type: research

Physical Exercise and Health, 1: An Overview of Terminology, Guidance, Benefits, and Risks
This article outlines the magnitude of the global problem. It discusses terms such as physical activity, aerobic exercise, muscle strengthening exercise, weight-bearing exercise, sitting time, and sedentariness. It presents and explains current guidance on physical activity, averaged across a week, for adults as well as special populations, including adolescents, the elderly, and pregnant women. It notes that immediate, short-term, and long-term benefits of exercise have been identified in thousands of randomized controlled trials (RCTs) and cohort studies, and pooled in hundreds of meta-analyses, for a wide range of neuro...
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

Lemborexant and Daridorexant for the Treatment of Insomnia: An Indirect Comparison Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed
Conclusions: In Phase 3 trials, the benefit-risk ratios for both lemborexant and daridorexant were favorable as measured by NNT, NNH, and LHH. Indirect comparisons of lemborexant with daridorexant suggest an efficacy advantage for lemborexant and a tolerability advantage for daridorexant.Clinical Trials Registration: NCT02783729, NCT02952820, NCT03545191, NCT03575104.PMID:37796657 | DOI:10.4088/JCP.23m14851 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Leslie Citrome Timothy R Juday Christie Lundwall Source Type: research

Exploratory Analysis of the Effects of Celecoxib on Cognitive Function in Vortioxetine-Treated Patients With Major Depressive Disorder in the PREDDICT Study: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Conclusions: Both treatment groups showed a reduction in depression-associated cognitive impairment. No superior clinical effect was reported for the add-on celecoxib group. HsCRP was modulated by neither vortioxetine nor add-on celecoxib.Trial Registration: ANZCTR identifier: ACTRN12617000527369.PMID:37796652 | DOI:10.4088/JCP.23m14829 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Emma Sampson Natalie T Mills Hikaru Hori Kathrin Schwarte Christa Hohoff Oliver Schubert Scott R Clark C élia Fourrier Bernhard T Baune Source Type: research

Physical Exercise and Health, 1: An Overview of Terminology, Guidance, Benefits, and Risks
This article outlines the magnitude of the global problem. It discusses terms such as physical activity, aerobic exercise, muscle strengthening exercise, weight-bearing exercise, sitting time, and sedentariness. It presents and explains current guidance on physical activity, averaged across a week, for adults as well as special populations, including adolescents, the elderly, and pregnant women. It notes that immediate, short-term, and long-term benefits of exercise have been identified in thousands of randomized controlled trials (RCTs) and cohort studies, and pooled in hundreds of meta-analyses, for a wide range of neuro...
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

Lemborexant and Daridorexant for the Treatment of Insomnia: An Indirect Comparison Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed
Conclusions: In Phase 3 trials, the benefit-risk ratios for both lemborexant and daridorexant were favorable as measured by NNT, NNH, and LHH. Indirect comparisons of lemborexant with daridorexant suggest an efficacy advantage for lemborexant and a tolerability advantage for daridorexant.Clinical Trials Registration: NCT02783729, NCT02952820, NCT03545191, NCT03575104.PMID:37796657 | DOI:10.4088/JCP.23m14851 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Leslie Citrome Timothy R Juday Christie Lundwall Source Type: research

Exploratory Analysis of the Effects of Celecoxib on Cognitive Function in Vortioxetine-Treated Patients With Major Depressive Disorder in the PREDDICT Study: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Conclusions: Both treatment groups showed a reduction in depression-associated cognitive impairment. No superior clinical effect was reported for the add-on celecoxib group. HsCRP was modulated by neither vortioxetine nor add-on celecoxib.Trial Registration: ANZCTR identifier: ACTRN12617000527369.PMID:37796652 | DOI:10.4088/JCP.23m14829 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Emma Sampson Natalie T Mills Hikaru Hori Kathrin Schwarte Christa Hohoff Oliver Schubert Scott R Clark C élia Fourrier Bernhard T Baune Source Type: research

Physical Exercise and Health, 1: An Overview of Terminology, Guidance, Benefits, and Risks
This article outlines the magnitude of the global problem. It discusses terms such as physical activity, aerobic exercise, muscle strengthening exercise, weight-bearing exercise, sitting time, and sedentariness. It presents and explains current guidance on physical activity, averaged across a week, for adults as well as special populations, including adolescents, the elderly, and pregnant women. It notes that immediate, short-term, and long-term benefits of exercise have been identified in thousands of randomized controlled trials (RCTs) and cohort studies, and pooled in hundreds of meta-analyses, for a wide range of neuro...
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

Lemborexant and Daridorexant for the Treatment of Insomnia: An Indirect Comparison Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed
Conclusions: In Phase 3 trials, the benefit-risk ratios for both lemborexant and daridorexant were favorable as measured by NNT, NNH, and LHH. Indirect comparisons of lemborexant with daridorexant suggest an efficacy advantage for lemborexant and a tolerability advantage for daridorexant.Clinical Trials Registration: NCT02783729, NCT02952820, NCT03545191, NCT03575104.PMID:37796657 | DOI:10.4088/JCP.23m14851 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Leslie Citrome Timothy R Juday Christie Lundwall Source Type: research

Earlier Use of Long-Acting Injectable Paliperidone Palmitate Versus Oral Antipsychotics in Patients With Schizophrenia: An Integrated Patient-Level Post Hoc Analysis
Conclusions: This post hoc analysis suggests that PP provides significant benefit in reducing TF or relapse compared with OAPs regardless of duration of illness and highlights the potential benefit of implementing PP earlier in the course of schizophrenia.Trial Registration: ClinicalTrials.gov identifiers NCT01157351 (PRIDE), NCT01081769 (PROSIPAL), and NCT02431702 (DREaM).PMID:37756123 | DOI:10.4088/JCP.23m14788 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 27, 2023 Category: Psychiatry Authors: Oliver J Lopena Larry D Alphs Martha Sajatovic Ibrahim Turkoz Liping Sun Karen L Johnston Jennifer K Sliwa Dean M Najarian H Lynn Starr Source Type: research

Dual Orexin Receptor Antagonists and Suicide Risk: Findings From the WHO Spontaneous Reporting Database
J Clin Psychiatry. 2023 Sep 27;84(6):23br14923. doi: 10.4088/JCP.23br14923.NO ABSTRACTPMID:37756127 | DOI:10.4088/JCP.23br14923 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 27, 2023 Category: Psychiatry Authors: Francesco Salvo Jean-Arthur Micoulaud-Franchi Laura Palagini Pierre A Geoffroy Source Type: research

Earlier Use of Long-Acting Injectable Paliperidone Palmitate Versus Oral Antipsychotics in Patients With Schizophrenia: An Integrated Patient-Level Post Hoc Analysis
Conclusions: This post hoc analysis suggests that PP provides significant benefit in reducing TF or relapse compared with OAPs regardless of duration of illness and highlights the potential benefit of implementing PP earlier in the course of schizophrenia.Trial Registration: ClinicalTrials.gov identifiers NCT01157351 (PRIDE), NCT01081769 (PROSIPAL), and NCT02431702 (DREaM).PMID:37756123 | DOI:10.4088/JCP.23m14788 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 27, 2023 Category: Psychiatry Authors: Oliver J Lopena Larry D Alphs Martha Sajatovic Ibrahim Turkoz Liping Sun Karen L Johnston Jennifer K Sliwa Dean M Najarian H Lynn Starr Source Type: research

Dual Orexin Receptor Antagonists and Suicide Risk: Findings From the WHO Spontaneous Reporting Database
J Clin Psychiatry. 2023 Sep 27;84(6):23br14923. doi: 10.4088/JCP.23br14923.NO ABSTRACTPMID:37756127 | DOI:10.4088/JCP.23br14923 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - September 27, 2023 Category: Psychiatry Authors: Francesco Salvo Jean-Arthur Micoulaud-Franchi Laura Palagini Pierre A Geoffroy Source Type: research