Solriamfetol for Attention-Deficit/Hyperactivity Disorder in Adults: A Double-Blind Placebo-Controlled Pilot Study
Conclusions: Solriamfetol may be a novel and effective treatment for the management of ADHD in adults. Further replication in larger trials is indicated.Trial Registration: ClinicalTrials.gov identifier: NCT04839562.PMID:37819836 | DOI:10.4088/JCP.23m14934 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Craig B H Surman Daniel M Walsh Nora Horick Maura DiSalvo Chloe Hutt Vater Daniel Kaufman Source Type: research

Physical Exercise and Health, 2: Benefits Associated With Different Levels and Patterns of Activity
This article states and explains the guidance about exercise for adults and for special populations such as the elderly, discusses general limitations of cohort studies, examines how many steps of walking a day suffice to improve health outcomes and at what level a ceiling is reached, considers at what speed these steps need to accrue, examines the benefits of exercise patterns such as vigorous intermittent lifestyle physical activity and weekend warrior workouts, discusses a study that examined different combinations of exercise, and explains the reasons behind the paradox that fitter persons need to perform apparently ha...
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

Solriamfetol for Attention-Deficit/Hyperactivity Disorder in Adults: A Double-Blind Placebo-Controlled Pilot Study
Conclusions: Solriamfetol may be a novel and effective treatment for the management of ADHD in adults. Further replication in larger trials is indicated.Trial Registration: ClinicalTrials.gov identifier: NCT04839562.PMID:37819836 | DOI:10.4088/JCP.23m14934 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Craig B H Surman Daniel M Walsh Nora Horick Maura DiSalvo Chloe Hutt Vater Daniel Kaufman Source Type: research

Physical Exercise and Health, 2: Benefits Associated With Different Levels and Patterns of Activity
This article states and explains the guidance about exercise for adults and for special populations such as the elderly, discusses general limitations of cohort studies, examines how many steps of walking a day suffice to improve health outcomes and at what level a ceiling is reached, considers at what speed these steps need to accrue, examines the benefits of exercise patterns such as vigorous intermittent lifestyle physical activity and weekend warrior workouts, discusses a study that examined different combinations of exercise, and explains the reasons behind the paradox that fitter persons need to perform apparently ha...
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

Solriamfetol for Attention-Deficit/Hyperactivity Disorder in Adults: A Double-Blind Placebo-Controlled Pilot Study
Conclusions: Solriamfetol may be a novel and effective treatment for the management of ADHD in adults. Further replication in larger trials is indicated.Trial Registration: ClinicalTrials.gov identifier: NCT04839562.PMID:37819836 | DOI:10.4088/JCP.23m14934 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Craig B H Surman Daniel M Walsh Nora Horick Maura DiSalvo Chloe Hutt Vater Daniel Kaufman Source Type: research

Physical Exercise and Health, 2: Benefits Associated With Different Levels and Patterns of Activity
This article states and explains the guidance about exercise for adults and for special populations such as the elderly, discusses general limitations of cohort studies, examines how many steps of walking a day suffice to improve health outcomes and at what level a ceiling is reached, considers at what speed these steps need to accrue, examines the benefits of exercise patterns such as vigorous intermittent lifestyle physical activity and weekend warrior workouts, discusses a study that examined different combinations of exercise, and explains the reasons behind the paradox that fitter persons need to perform apparently ha...
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

Solriamfetol for Attention-Deficit/Hyperactivity Disorder in Adults: A Double-Blind Placebo-Controlled Pilot Study
Conclusions: Solriamfetol may be a novel and effective treatment for the management of ADHD in adults. Further replication in larger trials is indicated.Trial Registration: ClinicalTrials.gov identifier: NCT04839562.PMID:37819836 | DOI:10.4088/JCP.23m14934 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Craig B H Surman Daniel M Walsh Nora Horick Maura DiSalvo Chloe Hutt Vater Daniel Kaufman Source Type: research

Physical Exercise and Health, 2: Benefits Associated With Different Levels and Patterns of Activity
This article states and explains the guidance about exercise for adults and for special populations such as the elderly, discusses general limitations of cohort studies, examines how many steps of walking a day suffice to improve health outcomes and at what level a ceiling is reached, considers at what speed these steps need to accrue, examines the benefits of exercise patterns such as vigorous intermittent lifestyle physical activity and weekend warrior workouts, discusses a study that examined different combinations of exercise, and explains the reasons behind the paradox that fitter persons need to perform apparently ha...
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

Solriamfetol for Attention-Deficit/Hyperactivity Disorder in Adults: A Double-Blind Placebo-Controlled Pilot Study
Conclusions: Solriamfetol may be a novel and effective treatment for the management of ADHD in adults. Further replication in larger trials is indicated.Trial Registration: ClinicalTrials.gov identifier: NCT04839562.PMID:37819836 | DOI:10.4088/JCP.23m14934 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Craig B H Surman Daniel M Walsh Nora Horick Maura DiSalvo Chloe Hutt Vater Daniel Kaufman Source Type: research

Physical Exercise and Health, 2: Benefits Associated With Different Levels and Patterns of Activity
This article states and explains the guidance about exercise for adults and for special populations such as the elderly, discusses general limitations of cohort studies, examines how many steps of walking a day suffice to improve health outcomes and at what level a ceiling is reached, considers at what speed these steps need to accrue, examines the benefits of exercise patterns such as vigorous intermittent lifestyle physical activity and weekend warrior workouts, discusses a study that examined different combinations of exercise, and explains the reasons behind the paradox that fitter persons need to perform apparently ha...
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

Solriamfetol for Attention-Deficit/Hyperactivity Disorder in Adults: A Double-Blind Placebo-Controlled Pilot Study
Conclusions: Solriamfetol may be a novel and effective treatment for the management of ADHD in adults. Further replication in larger trials is indicated.Trial Registration: ClinicalTrials.gov identifier: NCT04839562.PMID:37819836 | DOI:10.4088/JCP.23m14934 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 11, 2023 Category: Psychiatry Authors: Craig B H Surman Daniel M Walsh Nora Horick Maura DiSalvo Chloe Hutt Vater Daniel Kaufman Source Type: research

Exploratory Analysis of the Effects of Celecoxib on Cognitive Function in Vortioxetine-Treated Patients With Major Depressive Disorder in the PREDDICT Study: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Conclusions: Both treatment groups showed a reduction in depression-associated cognitive impairment. No superior clinical effect was reported for the add-on celecoxib group. HsCRP was modulated by neither vortioxetine nor add-on celecoxib.Trial Registration: ANZCTR identifier: ACTRN12617000527369.PMID:37796652 | DOI:10.4088/JCP.23m14829 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Emma Sampson Natalie T Mills Hikaru Hori Kathrin Schwarte Christa Hohoff Oliver Schubert Scott R Clark C élia Fourrier Bernhard T Baune Source Type: research

Physical Exercise and Health, 1: An Overview of Terminology, Guidance, Benefits, and Risks
This article outlines the magnitude of the global problem. It discusses terms such as physical activity, aerobic exercise, muscle strengthening exercise, weight-bearing exercise, sitting time, and sedentariness. It presents and explains current guidance on physical activity, averaged across a week, for adults as well as special populations, including adolescents, the elderly, and pregnant women. It notes that immediate, short-term, and long-term benefits of exercise have been identified in thousands of randomized controlled trials (RCTs) and cohort studies, and pooled in hundreds of meta-analyses, for a wide range of neuro...
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

Lemborexant and Daridorexant for the Treatment of Insomnia: An Indirect Comparison Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed
Conclusions: In Phase 3 trials, the benefit-risk ratios for both lemborexant and daridorexant were favorable as measured by NNT, NNH, and LHH. Indirect comparisons of lemborexant with daridorexant suggest an efficacy advantage for lemborexant and a tolerability advantage for daridorexant.Clinical Trials Registration: NCT02783729, NCT02952820, NCT03545191, NCT03575104.PMID:37796657 | DOI:10.4088/JCP.23m14851 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Leslie Citrome Timothy R Juday Christie Lundwall Source Type: research

Exploratory Analysis of the Effects of Celecoxib on Cognitive Function in Vortioxetine-Treated Patients With Major Depressive Disorder in the PREDDICT Study: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Conclusions: Both treatment groups showed a reduction in depression-associated cognitive impairment. No superior clinical effect was reported for the add-on celecoxib group. HsCRP was modulated by neither vortioxetine nor add-on celecoxib.Trial Registration: ANZCTR identifier: ACTRN12617000527369.PMID:37796652 | DOI:10.4088/JCP.23m14829 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - October 5, 2023 Category: Psychiatry Authors: Emma Sampson Natalie T Mills Hikaru Hori Kathrin Schwarte Christa Hohoff Oliver Schubert Scott R Clark C élia Fourrier Bernhard T Baune Source Type: research