Long-Term Safety and Efficacy of Initial and Repeat Treatment Courses With Zuranolone in Adult Patients With Major Depressive Disorder: Interim Results From the Open-Label, Phase 3 SHORELINE Study
Conclusions: Of patients who experienced TEAEs, most reported mild or moderately severe events, and responders to zuranolone experienced improvements in depressive symptoms with initial and repeat treatment courses.Trial Registration: ClinicalTrials.gov identifier: NCT03864614.PMID:38153320 | DOI:10.4088/JCP.23m14845 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 28, 2023 Category: Psychiatry Authors: Andrew J Cutler Gregory W Mattingly Susan G Kornstein Scott T Aaronson Robert Lasser Hongling Zhang Nilanjana Rana Colville Brown Seth Levin Catherine Miller Mona Kotecha Fiona Forrestal James Doherty Source Type: research

Magnitude and Correlates of Symptomatic, Global Illness, and Social Functioning Response; Out-of-Home Placement; and Length of Stay in 1,189 Consecutively Hospitalized Children and Adolescents With Mental Disorders
Conclusions: Higher admission BMI percentile, disturbed social interaction, disturbed drive/attention/impulse control, and substance abuse/dependence symptoms were independently associated with multiple poor outcomes in mentally ill youth requiring inpatient care. Knowledge of global and specific correlates of poor inpatient treatment outcomes may help inform treatment decisions.PMID:38153319 | DOI:10.4088/JCP.23m14897 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 28, 2023 Category: Psychiatry Authors: Viktor B N öhles Charlotte Jaite Kerstin Rubarth Fabiola H Heuer Katja B ödeker Laura Golz Sibylle M Winter Christoph U Correll Source Type: research

Long-Term Safety and Efficacy of Initial and Repeat Treatment Courses With Zuranolone in Adult Patients With Major Depressive Disorder: Interim Results From the Open-Label, Phase 3 SHORELINE Study
Conclusions: Of patients who experienced TEAEs, most reported mild or moderately severe events, and responders to zuranolone experienced improvements in depressive symptoms with initial and repeat treatment courses.Trial Registration: ClinicalTrials.gov identifier: NCT03864614.PMID:38153320 | DOI:10.4088/JCP.23m14845 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 28, 2023 Category: Psychiatry Authors: Andrew J Cutler Gregory W Mattingly Susan G Kornstein Scott T Aaronson Robert Lasser Hongling Zhang Nilanjana Rana Colville Brown Seth Levin Catherine Miller Mona Kotecha Fiona Forrestal James Doherty Source Type: research

Magnitude and Correlates of Symptomatic, Global Illness, and Social Functioning Response; Out-of-Home Placement; and Length of Stay in 1,189 Consecutively Hospitalized Children and Adolescents With Mental Disorders
Conclusions: Higher admission BMI percentile, disturbed social interaction, disturbed drive/attention/impulse control, and substance abuse/dependence symptoms were independently associated with multiple poor outcomes in mentally ill youth requiring inpatient care. Knowledge of global and specific correlates of poor inpatient treatment outcomes may help inform treatment decisions.PMID:38153319 | DOI:10.4088/JCP.23m14897 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 28, 2023 Category: Psychiatry Authors: Viktor B N öhles Charlotte Jaite Kerstin Rubarth Fabiola H Heuer Katja B ödeker Laura Golz Sibylle M Winter Christoph U Correll Source Type: research

Long-Term Safety and Efficacy of Initial and Repeat Treatment Courses With Zuranolone in Adult Patients With Major Depressive Disorder: Interim Results From the Open-Label, Phase 3 SHORELINE Study
Conclusions: Of patients who experienced TEAEs, most reported mild or moderately severe events, and responders to zuranolone experienced improvements in depressive symptoms with initial and repeat treatment courses.Trial Registration: ClinicalTrials.gov identifier: NCT03864614.PMID:38153320 | DOI:10.4088/JCP.23m14845 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 28, 2023 Category: Psychiatry Authors: Andrew J Cutler Gregory W Mattingly Susan G Kornstein Scott T Aaronson Robert Lasser Hongling Zhang Nilanjana Rana Colville Brown Seth Levin Catherine Miller Mona Kotecha Fiona Forrestal James Doherty Source Type: research

Magnitude and Correlates of Symptomatic, Global Illness, and Social Functioning Response; Out-of-Home Placement; and Length of Stay in 1,189 Consecutively Hospitalized Children and Adolescents With Mental Disorders
Conclusions: Higher admission BMI percentile, disturbed social interaction, disturbed drive/attention/impulse control, and substance abuse/dependence symptoms were independently associated with multiple poor outcomes in mentally ill youth requiring inpatient care. Knowledge of global and specific correlates of poor inpatient treatment outcomes may help inform treatment decisions.PMID:38153319 | DOI:10.4088/JCP.23m14897 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 28, 2023 Category: Psychiatry Authors: Viktor B N öhles Charlotte Jaite Kerstin Rubarth Fabiola H Heuer Katja B ödeker Laura Golz Sibylle M Winter Christoph U Correll Source Type: research

Long-Term Safety and Efficacy of Initial and Repeat Treatment Courses With Zuranolone in Adult Patients With Major Depressive Disorder: Interim Results From the Open-Label, Phase 3 SHORELINE Study
Conclusions: Of patients who experienced TEAEs, most reported mild or moderately severe events, and responders to zuranolone experienced improvements in depressive symptoms with initial and repeat treatment courses.Trial Registration: ClinicalTrials.gov identifier: NCT03864614.PMID:38153320 | DOI:10.4088/JCP.23m14845 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 28, 2023 Category: Psychiatry Authors: Andrew J Cutler Gregory W Mattingly Susan G Kornstein Scott T Aaronson Robert Lasser Hongling Zhang Nilanjana Rana Colville Brown Seth Levin Catherine Miller Mona Kotecha Fiona Forrestal James Doherty Source Type: research

"When Will All of This End?": A 65-Year-Old Man With Amyotrophic Lateral Sclerosis and Psychiatric Distress
J Clin Psychiatry. 2023 Dec 13;85(1):23ct15038. doi: 10.4088/JCP.23ct15038.ABSTRACTPatients with amyotrophic lateral sclerosis (ALS) are impacted both physically and psychiatrically during their illness. Emotional distress (ie, anxiety, depression, stress) is common in patients diagnosed with ALS, as prognosis is poor and there are very few effective treatments. The progression of symptoms is unpredictable, and all cases are terminal. Neuropsychiatric symptoms are also increasingly recognized as part of ALS symptomatology. There are currently no empirically supported interventions or best practices for adjustment to ALS. T...
Source: Journal of Clinical Psychiatry - December 21, 2023 Category: Psychiatry Authors: Ethan G Lester Ottavio V Vitolo Alice Flaherty Yvan Beaussant Margaret Cramer Rebecca Harley Jonah N Cohen Source Type: research

The Intense Psychological Burden of ALS, the Enduring Strength of People Living With ALS, and the Tools We Can Use to Help
J Clin Psychiatry. 2023 Dec 13;85(1):23com15173. doi: 10.4088/JCP.23com15173.NO ABSTRACTPMID:38127306 | DOI:10.4088/JCP.23com15173 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 21, 2023 Category: Psychiatry Authors: Doreen T Ho James D Berry Source Type: research

The Effectiveness of Metformin in Managing Second Generation Antipsychotic-Induced Weight Gain in Children and Adolescents
Conclusions: Adjuvant metformin helps manage AIWG in children and adolescents by flattening the upward AIWG trend rather than reversing it. The effect was more prominent before the development of obesity, suggesting that the early introduction of metformin for AIWG management may be warranted.PMID:38127310 | DOI:10.4088/JCP.23m14894 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 21, 2023 Category: Psychiatry Authors: Hua Chen Ning Lyu Chadi Calarge Austin De La Cruz Wenyaw Chan Source Type: research

A Comparison of Depressive Symptom Self-Reported Measures in the Texas Youth Depression and Suicide Research Network (TX-YDSRN)
Conclusions: The PHQ-A, QIDS-SR16, and VQIDS-SR5 are unidimensional, psychometrically acceptable self-reports of depressive prevalence or severity in adolescents and young adults in this sample. Total scale scores on any measure can be converted reliably to those on any other.PMID:38127311 | DOI:10.4088/JCP.23m14861 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 21, 2023 Category: Psychiatry Authors: Karabi Nandy A John Rush Thomas Carmody Beth D Kennard Graham J Emslie Holli Slater Taryn L Mayes Melissa DeFilippis Cynthia Garza Eric A Storch Sarah M Wakefield Madhukar H Trivedi Source Type: research

Physical Exercise and Health, 4: The Health Care Professional and Patient's Guide to Understanding What to Do, How, and Why-Part 2
This article is the fourth in a series on physical exercise and health. The article addresses health care professionals, patients, and the public and provides practical guidance on how to exercise with emphasis on understanding what to do, how, and why. Subjects covered include how cardiorespiratory, muscle-strengthening, load-bearing, balancing, and other exercises benefit the heart, strengthen muscles and bones, improve balance and stability, and reduce the risk of falls and fractures while providing both current and long-term gains related to health, mobility, independence, and quality of life. Examples are provided for...
Source: Journal of Clinical Psychiatry - December 21, 2023 Category: Psychiatry Authors: Chittaranjan Andrade Source Type: research

"When Will All of This End?": A 65-Year-Old Man With Amyotrophic Lateral Sclerosis and Psychiatric Distress
J Clin Psychiatry. 2023 Dec 13;85(1):23ct15038. doi: 10.4088/JCP.23ct15038.ABSTRACTPatients with amyotrophic lateral sclerosis (ALS) are impacted both physically and psychiatrically during their illness. Emotional distress (ie, anxiety, depression, stress) is common in patients diagnosed with ALS, as prognosis is poor and there are very few effective treatments. The progression of symptoms is unpredictable, and all cases are terminal. Neuropsychiatric symptoms are also increasingly recognized as part of ALS symptomatology. There are currently no empirically supported interventions or best practices for adjustment to ALS. T...
Source: Journal of Clinical Psychiatry - December 21, 2023 Category: Psychiatry Authors: Ethan G Lester Ottavio V Vitolo Alice Flaherty Yvan Beaussant Margaret Cramer Rebecca Harley Jonah N Cohen Source Type: research

The Intense Psychological Burden of ALS, the Enduring Strength of People Living With ALS, and the Tools We Can Use to Help
J Clin Psychiatry. 2023 Dec 13;85(1):23com15173. doi: 10.4088/JCP.23com15173.NO ABSTRACTPMID:38127306 | DOI:10.4088/JCP.23com15173 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 21, 2023 Category: Psychiatry Authors: Doreen T Ho James D Berry Source Type: research

The Effectiveness of Metformin in Managing Second Generation Antipsychotic-Induced Weight Gain in Children and Adolescents
Conclusions: Adjuvant metformin helps manage AIWG in children and adolescents by flattening the upward AIWG trend rather than reversing it. The effect was more prominent before the development of obesity, suggesting that the early introduction of metformin for AIWG management may be warranted.PMID:38127310 | DOI:10.4088/JCP.23m14894 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - December 21, 2023 Category: Psychiatry Authors: Hua Chen Ning Lyu Chadi Calarge Austin De La Cruz Wenyaw Chan Source Type: research