Chitosan-TPP Nanoparticles Stabilized by Poloxamer for Controlling the Release and Enhancing the Bioavailability of Doxazosin Mesylate: In Vitro, and In Vivo Evaluation.
CONCLUSIONS: The study proved that controlling the release of DM from NPs enhance its bioavailability and improve the compliance of patients with hypertension or benign prostatic hyperplasia.
PMID: 30884977 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - March 21, 2019 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Sensitive analysis of five alpha blockers in dosage forms and human plasma by field amplified sample injection combined with micellar electrokinetic chromatography
Publication date: May 2019Source: Microchemical Journal, Volume 146Author(s): Fathalla Belal, Mohamed Walash, Mona Fathy, Sahar Zayed, Hadeer BorgAbstractA new, sensitive and simple field amplified sample injection (FASI) combined with micellar electrokinetic chromatography (MEKC) was developed for the analysis of terazosin (TER), alfuzosin (ALF), tamsulosin (TAM), doxazosin (DOX) and silodosin (SIL). The separation was achieved with Tris buffer (30 mM, pH 9.2) containing 30 mM SDS and 8% butanol, applying a voltage of 28 kV at 25 °C. Under the optimal conditions, the sensitivity of FASI-MEKC was improved 25.3â€...
Source: Microchemical Journal - February 27, 2019 Category: Chemistry Source Type: research
Dual Effect of Doxazosin: Anticancer Activity on SH-SY5Y Neuroblastoma Cells and Neuroprotection on an In Vitro Model of Alzheimer's Disease
Publication date: Available online 14 February 2019Source: NeuroscienceAuthor(s): Bárbara Paranhos Coelho, Mariana Maier Gaelzer, Fernanda dos Santos Petry, Juliana Bender Hoppe, Vera Maria Treis Trindade, Christianne G. Salbego, Fátima T.C.R. GumaAbstractSeveral studies have demonstrated the antitumor effect of doxazosin, an α1-adrenergic blocker, against glioma and breast, bladder and prostate cancers. Doxazosin is also being evaluated as a treatment for posttraumatic stress disorder and alcoholism, and α1-adrenergic blockers have been linked to neuroprotection in neurodegenerative disorders, such as Alzheimer's Dise...
Source: Neuroscience - February 14, 2019 Category: Neuroscience Source Type: research
The interrelation of endothelial function and microvascular reactivity in different vascular beds, and risk assessment in hypertension: results from the Doxazosin –ramipril study
AbstractThere are several non-invasive methods to study endothelial function, but their interrelation and association to cardiovascular risk have not been well evaluated. We studied macrovascular and microvascular endothelial function simultaneously in different vascular beds in relation to cardiovascular mortality risk (Systematic Coronary Risk Evaluation, SCORE) and hypertension induced cardiac organ damage, and their interrelationship. The study investigated 71 hypertensive patients by forearm post-ischemic flow-mediated vasodilation, pulse wave analysis (applanation tonometry) and beta 2-adrenoceptor agonist stimulatio...
Source: Heart and Vessels - February 7, 2019 Category: Cardiology Source Type: research
The Evidence Paradox of the Effectiveness between the Paediatric and Adult Stone-Forming Population: A Narrative Review
Conclusion: The effectiveness of α-blockers and other medication as MET needs to be studied in multi-institutional, double-blind, placebo-controlled studies that would aim to prove superiority to placebo in contemporary clinical situations, with realistic end points and standardized outcome measure determination.Urol Int (Source: Urologia Internationalis)
Source: Urologia Internationalis - January 22, 2019 Category: Urology & Nephrology Source Type: research
[ASAP] Doxazosin Free-Base Structure Determination and Its Equilibrium Solubility Compared to Polymorphic Doxazosin Mesylate Forms A and H
Crystal Growth& DesignDOI: 10.1021/acs.cgd.8b01323 (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - January 15, 2019 Category: Chemistry Authors: Edeilson V. Gonzaga, Sara S. Vieira, J éssica L. J. Vilaca, Mayra Guerra, Marina G. Evangelista, Iara M. L. Rosa, Mariana M. Figueiredo, OlÃmpia M. M. S. Viana, Antonio C. Doriguetto Source Type: research
Cost-Effectiveness of Combination Therapy Versus Monotherapy in Benign Prostatic Hyperplasia: A Colombian Experience
ConclusionsThe combination of finasteride and doxazosin is cost-effective compared with dutasteride, tamsulosin, terazosin, and alfuzosin in patients with benign prostatic hyperplasia with moderate or severe symptoms who are older than 40 years. (Source: Value in Health Regional Issues)
Source: Value in Health Regional Issues - December 19, 2018 Category: International Medicine & Public Health Source Type: research
Drug adherence and drug-related problems in pharmacotherapy for lower urinary tract symptoms related to benign prostatic hyperplasia.
Authors: Zabkowski T, Saracyn M
Abstract
Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) is one of the most common urinary disorders in elderly men. In recent years, pharmacotherapy of BPH has increased the efficacy, including combination treatment mostly with two drug classes, namely, 5-α-reductase inhibitors and α-1-adrenolytics (alpha blockers) with a different pharmacological activity. Although pharmacological treatment of BPH is a success story in urology, daily practice suggests that several medical needs remain unmet. We aimed to evaluate drug adherence in pa...
Source: Journal of Physiology and Pharmacology - December 16, 2018 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
How to Read a Research Paper: An Exercise in Critical Thinking in the Context of an Epidemiologic Study on Tamsulosin and the Risk of Dementia.
This article discusses the study from the perspective of whether the hypothesis relating tamsulosin to dementia was set a priori or emerged after an exploratory exercise; whether tamsulosin crosses the blood-brain barrier for dementia as the event of interest to be attributable to treatment; whether the action of tamsulosin is plausibly related to dementia as a possible outcome; whether confounding was adequately addressed in the analyses; whether the duration of follow-up was sufficient for the event of interest to be attributable to tamsulosin; whether the absolute increase in the rate of incident dementia was clinically...
Source: Journal of Clinical Psychiatry - December 16, 2018 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
A quantitative LC-MS/MS method for determination of a small molecule agonist of EphA2 in mouse plasma and brain tissue.
Abstract
Compound 27 [1, 12-bis(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)dodecane-1,12-dione ] is a novel small molecule agonist of EphA2 receptor Tyrosine Kinase. It showed much improved activity for the activation of EphA2 receptor compared to the parental compound Doxazosin. To support further pharmacological and toxicological studies of the compound, a method using liquid chromatography and electrospray ionization tandem mass spectrometry (LC- MS/MS) has been developed for the quantification of this compound. Liquid-liquid extraction was used to extract the compound from mouse plasma and ...
Source: Biomedical Chromatography : BMC - December 12, 2018 Category: Biomedical Science Authors: Zhong B, Li Y, Idippily N, Petty A, Su B, Wang B Tags: Biomed Chromatogr Source Type: research
Cost Effectiveness of Combination Therapy Versus Monotherapy in Benign Prostatic Hyperplasia: A Colombian Experience
ConclusionsThe combination of finasteride and doxazosin is cost-effective compared with dutasteride, tamsulosin, terazosin, and alfuzosin in patients with benign prostatic hyperplasia with moderate or severe symptoms who are older than 40 years. (Source: Value in Health Regional Issues)
Source: Value in Health Regional Issues - November 9, 2018 Category: International Medicine & Public Health Source Type: research
Differential Effects of Doxazosin on Renin-Angiotensin-System-Regulating Aminopeptidase Activities in Neuroblastoma and Glioma Tumoral Cells.
CONCLUSION: Our results indicate that doxazosin modifies the proteolytic regulatory enzymes of RAS cascade, modulating the bioactive efficacy of the different angiotensin peptides, and therefore, of their functional roles as initiators/promoters of cell proliferation as autocrine/paracrine mediators.
PMID: 30370863 [PubMed - as supplied by publisher] (Source: CNS and Neurological Disorders Drug Targets)
Source: CNS and Neurological Disorders Drug Targets - October 29, 2018 Category: Drugs & Pharmacology Authors: RamÃrez-Expósito MJ, MartÃnez-Martos JM Tags: CNS Neurol Disord Drug Targets Source Type: research
Treatment and outcomes in pheochromocytomas and paragangliomas: a study of 110 cases from a single center
ConclusionThe outcomes seemed slightly better than previous studies. Long-term prognosis was similar between pheochromocytomas and paragangliomas. (Source: Endocrine)
Source: Endocrine - September 15, 2018 Category: Endocrinology Source Type: research
A Randomized, Placebo-controlled, Clinical Trial of Prazosin for the Treatment of Alcohol Use Disorder
Conclusions:
Our findings do not support the clinical utility of prazosin for all treatment-seeking AUD, but post hoc analyses indicate that it might have some efficacy in individuals who can tolerate it. Further work exploring the clinical utility of DBP as a treatment matching variable, and defining optimal values using sensitivity and specificity analyses, is warranted. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2018 Category: Addiction Tags: Original Research Source Type: research
Doxazosin for the treatment of co-occurring PTSD and alcohol use disorder: Design and methodology of a randomized controlled trial in military veterans
Posttraumatic stress disorder (PTSD) and alcohol use disorders (AUD) are two of the most common mental health disorders affecting civilians as well as military populations. If left untreated, individuals with co-occurring PTSD/AUD are at increased risk for developing other mental health problems (e.g., depression, anxiety), physical health problems, reduced resiliency and military readiness, and vocational and social impairment. Substantial gaps in the treatment of co-occurring PTSD/AUD exist and there is a critical need to develop more effective pharmacological treatments. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - August 23, 2018 Category: Radiology Authors: Sudie E. Back, Julianne C. Flanagan, Jennifer L. Jones, Isabel Augur, Alan L. Peterson, Stacey Young-McCaughan, David W. Shirley, Aisling Henschel, Jane E. Joseph, Brett T. Litz, Allison K. Hancock, John D. Roache, Jim Mintz, Jennifer S. Wachen, Terence M Source Type: research
