Adding Cyclooxygenase-2 inhibitor to alpha blocker for patients with benign prostate hyperplasia and elevated serum prostate specific antigen could not improve prostate biopsy detection rate but improve lower urinary tract symptoms.
CONCLUSIONS: Treatment with COX-2 inhibitor and α-blocker for 3 months could not improve prostatic cancer detection rate. But it could increase therapeutic effectiveness of LUTS in men with BPH and elevated PSA levels. The changes in Qmax and voided volume after combination treatment were significantly greater in patients with prostatic hyperplasia or inflammation than adenocarcinoma.
PMID: 24246211 [PubMed - in process] (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - November 24, 2013 Category: Cancer & Oncology Authors: Jhang JF, Jiang YH, Kuo HC Tags: Int J Clin Pract Source Type: research
Adding Cyclooxygenase‐2 inhibitor to alpha blocker for patients with benign prostate hyperplasia and elevated serum prostate specific antigen could not improve prostate biopsy detection rate but improve lower urinary tract symptoms
ConclusionsTreatment with COX‐2 inhibitor and α‐blocker for 3 months could not improve prostatic cancer detection rate. But it could increase therapeutic effectiveness of LUTS in men with BPH and elevated PSA levels. The changes in Qmax and voided volume after combination treatment were significantly greater in patients with prostatic hyperplasia or inflammation than adenocarcinoma. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - November 19, 2013 Category: Internal Medicine Authors: J.‐F. Jhang, Y.‐H. Jiang, H.‐C. Kuo Tags: Original Paper Source Type: research
Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in vitro.
Conclusion:(-)Doxazosin and (+)doxazosin show stereoselective plasma protein binding with a significant species difference among rats, dogs and humans.
PMID: 24241343 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - November 18, 2013 Category: Drugs & Pharmacology Authors: Sun JA, Kong DZ, Zhen YQ, Li Q, Zhang W, Zhang JH, Yin ZW, Ren LM Tags: Acta Pharmacol Sin Source Type: research
Role of Preoperative Adrenergic Blockade with Doxazosin on Hemodynamic Control during the Surgical Treatment of Pheochromocytoma: A Retrospective Study of 48 Cases.
Abstract
Authors evaluated the effects of selective adrenergic blockade by means of doxazosin on blood pressure in 48 patients operated on for pheochromocytoma by a multicenter retrospective study. Age, tumor size, surgical approach, and operative time were analyzed as predictive factors of intraoperative hypertensive crises. Forty-eight patients underwent adrenalectomy-four open surgery and 44 laparoscopic surgery-for pheochromocytoma of adrenal glands from 1998 to 2008 after preoperative administration of doxazosin. Perioperative cardiovascular status modifications and surgical medium- and long-term outc...
Source: The American Surgeon - November 1, 2013 Category: Surgery Authors: Conzo G, Musella M, Corcione F, Depalma M, Stanzione F, Della-Pietra C, Palazzo A, Napolitano S, Pasquali D, Milone M, Agostino-Sinisi A, Ferraro F, Santini L Tags: Am Surg Source Type: research
Comparing the effectiveness of intranasal desmopressin and doxazosin in men with nocturia: a pilot randomized clinical trial.
Conclusion: Intranasal desmopressin, is an effective symptomatic treatment of men with BPH complainingof nocturia, as well as doxazosin treatment.
PMID: 24078508 [PubMed - in process] (Source: Urology Journal)
Source: Urology Journal - October 1, 2013 Category: Urology & Nephrology Authors: Ceylan C, Ceylan T, Doluoglu OG, Yuksel S, Agras K Tags: Urol J Source Type: research
The alpha-1 adrenergic antagonist doxazosin for treatment of cocaine dependence: A pilot study
Abstract: Background: Medications decreasing central noradrenergic activity have been associated with attenuation of cocaine effects.Aims: This pilot study examined the efficacy of doxazosin versus placebo for reducing cocaine use in treatment-seeking cocaine dependent persons.Methods: We screened 108 cocaine dependent subjects and assigned 35 participants to receive either doxazosin (8mg/day) or placebo for 13 weeks. Participants were titrated on the study medication according to two different schedules. During the initial phase of the study, patients were titrated onto the study medication over an 8-week period (DOX-slow...
Source: Drug and Alcohol Dependence - June 6, 2013 Category: Addiction Authors: D. Shorter, J.A. Lindsay, T.R. Kosten Tags: Full Length Reports Source Type: research
