Stereoselective binding of doxazosin enantiomers to plasma proteins from rats, dogs and humans in vitro.

Conclusion:(-)Doxazosin and (+)doxazosin show stereoselective plasma protein binding with a significant species difference among rats, dogs and humans.
PMID: 24241343 [PubMed - as supplied by publisher]

Source: Acta Pharmacologica Sinica - November 18, 2013 Category: Drugs & Pharmacology Authors: Sun JA, Kong DZ, Zhen YQ, Li Q, Zhang W, Zhang JH, Yin ZW, Ren LM Tags: Acta Pharmacol Sin Source Type: research