Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria
In conclusion, this study preliminary documents the probable anti-QS and anti-virulence activities of doxazosin, which indicate its possible application as an alternative or in addition to antibiotics. However, extended toxicological and pharmacological investigations are essential to approve the feasible clinical application of doxazosin as novel efficient anti-virulence agent. KEY POINTS: • Anti-hypertensive doxazosin acquires anti-quorum sensing activities • Doxazosin diminishes the virulence of Proteus mirabilis and Pseudomonas aeruginosa • Doxazosin could dimmish the bacterial espionage.PMID:37079062 | DOI:10.10...
Source: Applied Microbiology and Biotechnology - April 20, 2023 Category: Microbiology Authors: Mahmoud A Elfaky Samar S Elbaramawi Ahmed G Eissa Tarek S Ibrahim El-Sayed Khafagy Mohamed A M Ali Wael A H Hegazy Source Type: research
Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria
In conclusion, this study preliminary documents the probable anti-QS and anti-virulence activities of doxazosin, which indicate its possible application as an alternative or in addition to antibiotics. However, extended toxicological and pharmacological investigations are essential to approve the feasible clinical application of doxazosin as novel efficient anti-virulence agent. KEY POINTS: • Anti-hypertensive doxazosin acquires anti-quorum sensing activities • Doxazosin diminishes the virulence of Proteus mirabilis and Pseudomonas aeruginosa • Doxazosin could dimmish the bacterial espionage.PMID:37079062 | DOI:10.10...
Source: Applied Microbiology and Biotechnology - April 20, 2023 Category: Microbiology Authors: Mahmoud A Elfaky Samar S Elbaramawi Ahmed G Eissa Tarek S Ibrahim El-Sayed Khafagy Mohamed A M Ali Wael A H Hegazy Source Type: research
The Effects of Verapamil, Hydralazine, and Doxazosin on Renin, Aldosterone, and the Ratio Thereof
ConclusionWe conclude that the assumption that these drugs can be used with little consequence to the aldosterone-to-renin cannot be substantiated. While it is possible that they are indeed the best option when full antihypertensive drug cessation is infeasible, the potential effects of these drugs must still be taken into account when interpreting the aldosterone-to-renin ratio. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - April 1, 2023 Category: Cardiology Source Type: research
Anti-cell Proliferative Mechanism of Doxazosin on Human Oral Cancer Cells Through the Modulation of Antioxidant and Apoptotic Pathway
Appl Biochem Biotechnol. 2023 Mar 21. doi: 10.1007/s12010-023-04412-1. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC), a global threatening disease, is reported mostly in the middle and elderly male population. Even though the exact cause of OSCC was not known, consumption of tobacco in any form has been reported in most of OSCC patients. OSCC is a massive invasive type of cancer which easily spreads to the distant organs. Hence treating it at appropriate time is necessary and the rate of OSCC incidence is also constantly increasing. At present, chemoradiation is the only therapy prescribed for OSCC pati...
Source: Applied Biochemistry and Biotechnology - March 21, 2023 Category: Biochemistry Authors: Dayuan Xing Li Li Di Meng Yanhui Zhang Feng Ma Source Type: research
Anti-cell Proliferative Mechanism of Doxazosin on Human Oral Cancer Cells Through the Modulation of Antioxidant and Apoptotic Pathway
Appl Biochem Biotechnol. 2023 Mar 21. doi: 10.1007/s12010-023-04412-1. Online ahead of print.ABSTRACTOral squamous cell carcinoma (OSCC), a global threatening disease, is reported mostly in the middle and elderly male population. Even though the exact cause of OSCC was not known, consumption of tobacco in any form has been reported in most of OSCC patients. OSCC is a massive invasive type of cancer which easily spreads to the distant organs. Hence treating it at appropriate time is necessary and the rate of OSCC incidence is also constantly increasing. At present, chemoradiation is the only therapy prescribed for OSCC pati...
Source: Applied Biochemistry and Biotechnology - March 21, 2023 Category: Biochemistry Authors: Dayuan Xing Li Li Di Meng Yanhui Zhang Feng Ma Source Type: research
A Double-Blind Randomized Controlled Trial of Doxazosin for Co-Occurring PTSD and Alcohol Use Disorder in Veterans
Conclusions: Doxazosin was safe and tolerable but was not more effective than placebo in reducing PTSD or AUD severity in this dually diagnosed sample. Clinical considerations such as heterogeneity of PTSD and AUD presentation and potential moderators are discussed in the context of future research directions.Trial Registration: ClinicalTrials.gov Identifier: NCT02500602.PMID:36883885 | DOI:10.4088/JCP.21m14367 (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - March 8, 2023 Category: Psychiatry Authors: Sudie E Back Julianne C Flanagan Jim Mintz Kathleen T Brady Jennifer Jones Amber M Jarnecke Jane E Joseph David W Shirley Robert J Malcolm Mark Hamner Brett T Litz Barbara L Niles Stacey Young-McCaughan Terence M Keane Alan L Peterson Source Type: research
Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activity
Ann Med. 2023 Dec;55(1):543-557. doi: 10.1080/07853890.2022.2164047.ABSTRACTThe sympathetic nervous system and the immune system are responsible for producing neurotransmitters and cytokines that interact by binding to receptors; due to this, there is communication between these systems. Liver immune cells and nerve fibres are systematically distributed in the liver, and the partial overlap of both patterns may favour interactions between certain elements. Dendritic cells are attached to fibroblasts, and nerve fibres are connected via the dendritic cell-fibroblast complex. Receptors for most neuroactive substances, such as...
Source: Annals of Medicine - February 24, 2023 Category: Internal Medicine Authors: Mariana Yazmin Medina Piza ño Mar ía de Jesús Loera Arias Roberto Montes de Oca Luna Odila Saucedo C árdenas Javier Ventura Ju árez Martin Humberto Mu ñoz Ortega Source Type: research
Prophylactic doxazosin reduces urinary retention and promotes recovery after total joint arthroplasty: A randomized controlled trial
Conclusion: Our results support the routine use of prophylactic doxazosin in male patients to decrease POUR rate and promote postoperative recovery under the setting of modern enhanced recovery after TJA. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 9, 2023 Category: Drugs & Pharmacology Source Type: research
