3-year treatment outcomes of water vapor thermal therapy (Rez ūm System) compared to doxazosin, finasteride and combination drug therapy for men with benign prostatic hyperplasia: cohort data from the Medical Therapy of Prostatic Symptoms (MTOPS) Trial
This evaluation of long-term outcomes of treatment for lower urinary tract symptoms due to benign prostatic hyperplasia compares a one-time water vapor thermal therapy procedure with daily medical therapy in cohorts from the Medical Therapy of Prostatic Symptoms (MTOPS) study. (Source: The Journal of Urology)
Source: The Journal of Urology - February 27, 2018 Category: Urology & Nephrology Authors: Nikhil Gupta, Tyson Rogers, Bradley Holland, Sevann Helo, Danuta Dynda, Kevin T. McVary Source Type: research
Three-Year Treatment Outcomes of Water Vapor Thermal Therapy Compared to Doxazosin, Finasteride and Combination Drug Therapy in Men with Benign Prostatic Hyperplasia: Cohort Data from the MTOPS Trial
We evaluated the long-term outcomes of treatment of lower urinary tract symptoms due to benign prostatic hyperplasia to compare a 1-time water vapor thermal therapy procedure with daily medical therapy in cohorts from the MTOPS (Medical Therapy of Prostatic Symptoms) study. (Source: The Journal of Urology)
Source: The Journal of Urology - February 27, 2018 Category: Urology & Nephrology Authors: Nikhil Gupta, Tyson Rogers, Bradley Holland, Sevann Helo, Danuta Dynda, Kevin T. McVary Tags: Adult Urology Source Type: research
3-year treatment outcomes of water vapor thermal therapy (Rez ūm System) compared to doxazosin, finasteride and combination drug therapy for men with benign prostatic hyperplasia: cohort data from the Medical Therapy of Prostatic Symptoms (MTOPS) Trial
This evaluation of long-term outcomes of treatment for lower urinary tract symptoms due to benign prostatic hyperplasia compares a one-time water vapor thermal therapy procedure with daily medical therapy in cohorts from the Medical Therapy of Prostatic Symptoms (MTOPS) study. (Source: The Journal of Urology)
Source: The Journal of Urology - February 27, 2018 Category: Urology & Nephrology Authors: Nikhil Gupta, Tyson Rogers, Bradley Holland, Sevann Helo, Danuta Dynda, Kevin T. McVary Source Type: research
An Open-Label Study of Doxazosin Extended-Release for PTSD: Findings and Recommendations for Future Research on Doxazosin
FOCUS,Volume 16, Issue 1, Page 67-73, Winter 2018. (Source: FOCUS)
Source: FOCUS - January 24, 2018 Category: Psychiatry Authors: Anne Richards Sabra Inslicht Leslie Micaela Ruoff Thomas James Metzler Lizabeth Alexandra Goldstein Christen Mary Chapman Samantha Qirko Hubachek Thomas Coogan Neylan Source Type: research
Tamsulosin and the risk of dementia in older men with benign prostatic hyperplasia
ConclusionTamsulosin may increase the risk of dementia in older men with BPH. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - January 1, 2018 Category: Drugs & Pharmacology Authors: Yinghui Duan, James J. Grady, Peter C. Albertsen, Z. Helen Wu Tags: ORIGINAL REPORT Source Type: research
The usefulness of a single arm cuff oscillometric method (Arteriograph) to assess changes in central aortic blood pressure and arterial stiffness by antihypertensive treatment: results from the Doxazosin-Ramipril Study.
CONCLUSIONS: Antihypertensive treatment reduced aortic systolic BP more than brachial BP and improved arterial stiffness. Blocking the renin-angiotensin system may have additional effects beyond BP reduction. We demonstrate the feasibility of the Arteriograph to monitor changes in BP and arterial stiffness by treatment.
PMID: 29073803 [PubMed - as supplied by publisher] (Source: Blood Pressure)
Source: Blood Pressure - October 28, 2017 Category: Hematology Tags: Blood Press Source Type: research
Adenoviral ‑bone morphogenetic protein‑7 and/or doxazosin therapies promote the reversion of fibrosis/cirrhosis in a cirrhotic hamster model.
In conclusion, the adenovirus‑BMP‑7 gene therapy and the doxazosin therapy are potential candidates for the diminution of fibrosis in the liver, although combination of both therapies does not improve the individual anti‑fibrotic effect once cirrhosis is established.
PMID: 29039539 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Abstract 148: Association of Socioeconomic Context With Blood Pressure Response and Cardiovascular Outcomes in ALLHAT [Session Title: Clinical Trials in Hypertension and Related Morbidities]
Introduction: Observational studies demonstrate that in low socioeconomic (SE) communities, where residents face social challenges and fewer opportunities for healthy lifestyle behaviors or quality care, blood pressure (BP) is higher and there are worse cardiovascular (CV) outcomes. Yet whether the effectiveness of antihypertensive therapy on BP control and CV outcomes varies by SE context in a randomized clinical trial (RCT) - where patients are treated under a standard protocol - is unknown.Methods: We used data from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), which randomize...
Source: Hypertension - September 14, 2017 Category: Cardiology Authors: Andi Shahu, Jeph Herrin, Sanket S Dhruva, Nihar R Desai, Harlan M Krumholz, Erica S Spatz Tags: Oral Abstract Presentations Source Type: research
Safety assessments in the avoidance of preoperative α-receptor blockade in phaeochromocytoma surgery: the pitfalls of a zero numerator
Editor —The recent observational case series reported by Groeben and colleagues1 addressing the avoidance of preoperative α-receptor blockade in patients undergoing phaeochromocytoma surgery clearly challenges conventional thought. Their study showed that the maximal intraoperative blood pressure in non-α-blocked patients was no different than in those having received preoperative phenoxybenzamine or doxazosin therap y (185 mm Hgvs 178 mm Hg, respectively;P=0.25). In addition, there were no major complications reported – notably an absence of myocardial infarction (MI) – making this practice, at least accordin...
Source: British Journal of Anaesthesia - September 8, 2017 Category: Anesthesiology Source Type: research
Poster 404: Doxazosin for Treatment of Refractory Autonomic Dysreflexia: A Case Report
Sara Raiser: I Have No Relevant Financial Relationships To Disclose (Source: PM and R)
Source: PM and R - September 1, 2017 Category: Rehabilitation Authors: Sara N. Raiser, Heather Asthagiri Source Type: research
Doxazosin nanoencapsulation improves its in vitro antiproliferative and anticlonogenic effects on breast cancer cells
In conclusion, the nanoencapsulation of doxazosin improved its in vitro effects in MCF7 cells, without changing the mechanism of cell death underlying its toxicity. This approach was fundamental to reduce the long-term in vitro ability of the remaining tumor cells to form new colonies after the treatment, potentially reducing the risk of tumor recurrence. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 26, 2017 Category: Drugs & Pharmacology Source Type: research
Doxazosin nanoencapsulation improves its in vitro antiproliferative and anticlonogenic effects on breast cancer cells.
In conclusion, the nanoencapsulation of doxazosin improved its in vitro effects in MCF7 cells, without changing the mechanism of cell death underlying its toxicity. This approach was fundamental to reduce the long-term in vitro ability of the remaining tumor cells to form new colonies after the treatment, potentially reducing the risk of tumor recurrence.
PMID: 28750355 [PubMed - as supplied by publisher] (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 24, 2017 Category: Drugs & Pharmacology Authors: Krai J, Beckenkamp A, Gaelzer MM, Pohlmann AR, Guterres SS, Filippi-Chiela EC, Salbego C, Buffon A, Beck RCR Tags: Biomed Pharmacother Source Type: research
Comparison of phenoxybenzamine and doxazosin in perioperative management of patients with pheochromocytoma.
CONCLUSIONS: there are no clinically relevant differences between patients with pheochromocytoma prepared to adrenalectomy with DOX or PhB.
PMID: 28715066 [PubMed - as supplied by publisher] (Source: Polish Heart Journal)
Source: Polish Heart Journal - July 17, 2017 Category: Cardiology Authors: Malec K, Miśkiewicz P, Witkowska A, Krajewska E, Toutounchi S, Gałązka Z, Piotrowski M, Kącka A, Bednarczuk T, Ambroziak U Tags: Kardiol Pol Source Type: research
