Emerging drugs in phase II and III clinical development for the treatment of alcohol use disorder
Expert Opin Emerg Drugs. 2024 Apr 12. doi: 10.1080/14728214.2024.2342951. Online ahead of print.ABSTRACTINTRODUCTION: Alcohol Use Disorder (AUD) poses an ongoing significant global health burden. AUD is highly prevalent and affects not only the individuals with AUD, but also their communities and society at large. Even though pharmacotherapy is an integral part of AUD treatment, the few available substances show limited efficacy and limited clinical impact. Thus, there is a need for new innovative pharmacotherapeutic approaches.AREAS COVERED: This paper provides a comprehensive review of drugs approved for the treatment of...
Source: Expert Opinion on Emerging Drugs - April 12, 2024 Category: Drugs & Pharmacology Authors: Sophie K öhne Thomas Hillemacher Alexander Glahn Patrick Bach Source Type: research
Cannabinoid hyperemesis and pheochromocytoma hypertensive urgency: a case report
ConclusionHyperemesis can cause hypertensive events in patients with pheochromocytoma by increasing abdominal pressure, leading to catecholamine release. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - March 19, 2024 Category: General Medicine Source Type: research
Doxazosin inhibits vasculogenic mimicry in human non ‑small cell lung cancer through inhibition of the VEGF‑A/VE‑cadherin/mTOR/MMP pathway
In conclusion, the present study demonstrated that doxazosin displayed anti-VM activity in an NSCLC cell model through the downregulation of VEGF-A and VE-cadherin levels, and the suppression of signaling pathways related to the receptor tyrosine kinase, EphA2, protein kinases, AKT and mTOR, and proteases, MMP-2 and MMP-9. These results support the add-on anti-VM effect of doxazosin as a potential agent against NSCLC.PMID:38455663 | PMC:PMC10918514 | DOI:10.3892/ol.2024.14303 (Source: Oncology Letters)
Source: Oncology Letters - March 8, 2024 Category: Cancer & Oncology Authors: Jui-Ling Hsu Wohn-Jenn Leu Lih-Ching Hsu Chia-Hsun Hsieh Jih-Hwa Guh Source Type: research
The combination of doxazosin and metyrosine as a preoperative treatment for pheochromocytomas and paragangliomas
ConclusionThe combination of metyrosine and doxazosin as a preoperative treatment for PPGLs affects intraoperative circulatory hemodynamics, such as a reduced occurrence of blood pressure elevation during surgery. Further research is necessary to identify patients who will benefit most from this combination treatment. (Source: Endocrine)
Source: Endocrine - January 11, 2024 Category: Endocrinology Source Type: research
Giant Negative T Waves in an Elderly Patient with Generalized Pain and Weakness
A 72-year-old male with a history of hypertension and chronic kidney disease presented to our emergency department complaining of numbness in his arms and legs, diarrhea, generalized pain, and weakness for 10 days, which gradually worsened and made moving difficult. His medications included trichloromethiazide, azosemide, doxazosin, nifedipine, carvedilol, and cilostazol. Additionally, prednisone had been used to treat cholesterol embolisms in the toes. Approximately 1 month prior, osteoporosis due to chronic kidney disease and steroid use was suspected, and denosumab therapy and calcium replacement were initiated. (Source...
Source: The American Journal of Medicine - December 30, 2023 Category: General Medicine Authors: Yoshikazu Hirose, Nobuhiro Sato, Yasuo Hirose Tags: ECG image of the month Source Type: research
Giant negative T waves in an elder with generalized pain and weakness
A 72-year-old man with a history of hypertension and chronic kidney disease presented to our emergency department complaining of numbness in his arms and legs, diarrhea, generalized pain, and weakness for 10 days, which gradually worsened and made moving difficult. His medications included trichloromethiazide, azosemide, doxazosin, nifedipine, carvedilol, and cilostazol. Additionally, prednisone had been used to treat cholesterol embolisms in the toes. Approximately 1 month prior, osteoporosis due to chronic kidney disease and steroid use was suspected, and denosumab therapy and calcium replacement ware initiated. (Source:...
Source: The American Journal of Medicine - December 30, 2023 Category: General Medicine Authors: Yoshikazu Hirose, Nobuhiro Sato, Yasuo Hirose Tags: ECG image of the month Source Type: research
Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
CONCLUSIONS: Our findings highlight the potential of DOXA as a therapeutic option for metastatic TNBC, warranting further investigation.PMID:37924112 | PMC:PMC10625208 | DOI:10.1186/s13046-023-02866-z (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - November 4, 2023 Category: Cancer & Oncology Authors: Seongjae Kim Jung Min Park Soeun Park Eunsun Jung Dongmi Ko Minsu Park Juyeon Seo Kee Dal Nam Yong Koo Kang Kyoungmin Lee Lee Farrand Yoon-Jae Kim Ji Young Kim Jae Hong Seo Source Type: research
Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
CONCLUSIONS: Our findings highlight the potential of DOXA as a therapeutic option for metastatic TNBC, warranting further investigation.PMID:37924112 | PMC:PMC10625208 | DOI:10.1186/s13046-023-02866-z (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - November 4, 2023 Category: Cancer & Oncology Authors: Seongjae Kim Jung Min Park Soeun Park Eunsun Jung Dongmi Ko Minsu Park Juyeon Seo Kee Dal Nam Yong Koo Kang Kyoungmin Lee Lee Farrand Yoon-Jae Kim Ji Young Kim Jae Hong Seo Source Type: research
Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
CONCLUSIONS: Our findings highlight the potential of DOXA as a therapeutic option for metastatic TNBC, warranting further investigation.PMID:37924112 | PMC:PMC10625208 | DOI:10.1186/s13046-023-02866-z (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - November 4, 2023 Category: Cancer & Oncology Authors: Seongjae Kim Jung Min Park Soeun Park Eunsun Jung Dongmi Ko Minsu Park Juyeon Seo Kee Dal Nam Yong Koo Kang Kyoungmin Lee Lee Farrand Yoon-Jae Kim Ji Young Kim Jae Hong Seo Source Type: research
Suppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
CONCLUSIONS: Our findings highlight the potential of DOXA as a therapeutic option for metastatic TNBC, warranting further investigation.PMID:37924112 | PMC:PMC10625208 | DOI:10.1186/s13046-023-02866-z (Source: Clinical Prostate Cancer)
Source: Clinical Prostate Cancer - November 4, 2023 Category: Cancer & Oncology Authors: Seongjae Kim Jung Min Park Soeun Park Eunsun Jung Dongmi Ko Minsu Park Juyeon Seo Kee Dal Nam Yong Koo Kang Kyoungmin Lee Lee Farrand Yoon-Jae Kim Ji Young Kim Jae Hong Seo Source Type: research
