Drug repositioning: doxazosin attenuates the virulence factors and biofilm formation in Gram-negative bacteria

In conclusion, this study preliminary documents the probable anti-QS and anti-virulence activities of doxazosin, which indicate its possible application as an alternative or in addition to antibiotics. However, extended toxicological and pharmacological investigations are essential to approve the feasible clinical application of doxazosin as novel efficient anti-virulence agent. KEY POINTS: • Anti-hypertensive doxazosin acquires anti-quorum sensing activities • Doxazosin diminishes the virulence of Proteus mirabilis and Pseudomonas aeruginosa • Doxazosin could dimmish the bacterial espionage.PMID:37079062 | DOI:10.1007/s00253-023-12522-3
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Source Type: research