Temporal Trends in Opioid References in Popular Hip-Hop Song Lyrics
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Letter to the Editor Source Type: research

Cross-cultural Applicability of the 12-Step Model: A Comparison of Narcotics Anonymous in the USA and Iran
Conclusion: NA, a 12-step program developed in a Western, predominantly Christian-oriented country, was adapted widely in the Islamic Republic of Iran, a setting different in culture, language, ethnicity, and religious orientation. The growth in its membership derives, in part, from specific innovations that may have broader applicability in other settings. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Immigration Status and Substance Use Disorder-related Mortality in Sweden: A National Longitudinal Registry Study
This study examined the association between first- and second-generation immigrant status and alcohol- or drugs other than alcohol-related (primarily opioids) mortality for those with risky substance use. Methods: A Swedish longitudinal, 2003 to 2017, registry study combined Addiction Severity Index (ASI) assessment data with mortality data (n = 15 601). Due to missing data, the analysis sample for this study was 15 012. Multivariate models tested the relationship between immigration status and drugs other than alcohol or alcohol-related mortality, controlling for demographics and the 7 ASI composite scores (CS)...
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Disparities Between US Opioid Overdose Deaths and Treatment Capacity: A Geospatial and Descriptive Analysis
Conclusion: Assessing the overlay between treatment capacity and need demonstrated that regional imbalances exist. These data can aid in strategic planning to correct the mismatch and potentially reduce mortality in the most challenged geographic regions. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Multimethod Formative Research to Improve the Training and Delivery of Tobacco-cessation Interventions in Behavioral Health Settings
Conclusions: Using results from this formative research to revise delivery and content of existing smoking-cessation training for behavioral health providers may address barriers to assisting clients with smoking cessation. Additional research to determine the efficacy of the adapted training is needed. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

The Association Between Antenatal Maternal Self-reported Substance Use, Maternal Characteristics, and Obstetrical Variables
Conclusion: Substance use disorders during pregnancy are an often underestimated cause of maternal, fetal, and neonatal complications. Limited studies have examined the relationship between maternal characteristics and associated illicit or nonillicit drug use. The absence of correlation between maternal demographics and disclosure of illicit substance use demonstrates the fact that all antepartum patients are at risk for these behaviors. Furthermore, the fact that women who did not disclose their illicit drug use were less likely to seek complete prenatal care reflects the need for physicians to provide a destigmatized ...
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

The Substance Use Intervention Team: A Preliminary Analysis of a Population-level Strategy to Address the Opioid Crisis at an Academic Health Center
This report assesses the first 5 months of implementation and associations with patient health and healthcare utilization. Methods: Patient demographic and screening data were extracted from the administrative data warehouse of the electronic health record (EHR) infrastructure. Distribution of sample characteristics for positive initial screens for opioid misuse was tested against those of all patients screened using a 2-tailed test of proportions (P  (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Randomized Trial of an Innovative Electronic Screening and Brief Intervention for Reducing Drinking Among Women of Childbearing Age
Objectives: To evaluate the efficacy of an innovative, self-administered, electronic Screening and Brief Intervention (e-SBI) in English and Spanish, “DrinkWise,” for reducing drinking among nonpregnant women of childbearing age. Methods: A parallel design, phase 1 trial included 185 nonpregnant women reporting risky drinking (8 or more drinks in a week or 3 or more drinks in a day) who were recruited from 2 publicly funded Nutritional Assistance for Women, Infants and Children (WIC) program sites in the United States from 2016 to 2017. Participants were 18 to 44 years in age, 75% of Hispanic ethnicity, 44...
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Patient-centered Outcomes in Participants of a Buprenorphine Monthly Depot (BUP-XR) Double-blind, Placebo-controlled, Multicenter, Phase 3 Study
Objective: Opioid use disorder (OUD) is associated with physical, social, psychological, and economic burden. This analysis assessed the effects of RBP-6000, referred to as BUP-XR (extended-release buprenorphine), a subcutaneously injected, monthly buprenorphine treatment for OUD compared with placebo on patient-centered outcomes measuring meaningful life changes. Methods: Patient-centered outcomes were collected in a 24-week, phase 3, placebo-controlled study assessing the efficacy, safety, and tolerability of BUP-XR 300/300 mg (6 × 300 mg) and 300/100 mg (2 × 300 mg followed by 4 ×...
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Cannabis Use Based on Urine Drug Screens in Pregnancy and Its Association With Infant Birth Weight
This study aims to clarify any association between infant birth weight and cannabis use in pregnancy based on urine drug screens. Methods: A retrospective medical record review of singleton births from August 2013 through December 2014 with available urine drug screens (UDS) at initiation of prenatal care and delivery was conducted at a large tertiary academic referral center. Patients who used drugs other than cannabis were excluded. Results: The prevalence of cannabis use in pregnancies not complicated by use of other drugs as evidenced by tetrahydrocannabinol in the urine of 2173 patients was 22.6%. Infants born t...
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Genetic Variant in the CRH-binding Protein Gene (CRHBP) is Associated With Cessation of Cocaine Use in Methadone Maintenance Patients With Opioid Addiction
Conclusions: Reduction in cocaine abuse among MMT patients may be mediated by a genetic effect in a stress-related gene (CRHBP SNP rs1500 minor C allele). Evaluations of larger samples, additional SNPs, and different populations are needed to support these findings. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Provision of and Barriers to Integrating Reproductive and Sexual Health Services for Reproductive-age Women in Opioid Treatment Programs
Conclusions: NC OTPs are a logical setting for integrating RSH services to meet the needs of reproductive-age women in treatment for OUD. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Integrating Reproductive Health Services Into Opioid Treatment Facilities: A Missed Opportunity to Prevent Opioid-exposed Pregnancies and Improve the Health of Women Who Use Drugs
Opioid treatment programs (OTPs) are federally mandated to provide certain medical services to patients, and are often the only place where people with substance use disorders (SUD) obtain medical care. Just as medication for addiction treatment (MAT) should be part of comprehensive addiction care, so should reproductive health care be a part of comprehensive medical care. The most significant barrier that must be overcome is that the majority of OTPs believe that it is outside their scope of service to provide reproductive health services. Reproductive health care is basic medical care. It is imperative for the long-term ...
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Commentary Source Type: research

Editor's note: Congratulations to the 2019 Author and Reviewer Award Winners
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - November 1, 2019 Category: Addiction Tags: Editorial Source Type: research

Successful Management of Gamma-hydroxybutyrate (GHB) Withdrawal Using Baclofen as a Standalone Therapy: A Case Report
Conclusion: In keeping with other case reports, baclofen appears to have potential to be used in the management of GHB withdrawal. Here, we presented a case of severe GHB withdrawal which was managed solely by baclofen. Clinical research is needed to evaluate baclofen's potential as a standalone treatment for GHB withdrawal. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Case Reports Source Type: research

Psychotropics in Your Medicine Cabinet: A Case Study of Dimenhydrinate Use
We present a case of a woman in her forties, with a psychiatric history of bipolar disorder, and complex concurrent medical history including familial Mediterranean fever (FMF), and fibromyalgia, admitted for withdrawal management of her intravenous dimenhydrinate use. As a result of her FMF, there were numerous hospital admissions and treatment which required intravenous access. Hence, a physician-inserted intravenous access port was placed on her chest. The port was maintained monthly with the help of a community agency. In this port, she was injecting 100 to 200 mg of dimenhydrinate hourly for its euphoric and calming...
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Case Reports Source Type: research

Initiation and Rapid Titration of Methadone in an Acute Care Setting for the Treatment of Opioid Use Disorder: A Case Report
We report a case of an individual who successfully completed initiation and rapid methadone titration for treatment of opioid use disorder in an acute care setting. Discussion: Utilizing divided dosing intervals and regular monitoring for toxicity, the patient received a cumulative methadone dose of 130 mg total within the first 48 hours of admission with continuation of a similar dose subsequently. No adverse events occurred over a 9-day follow-up period. The case report described here highlights the potential acute care settings may offer for the successful initiation and rapid titration of methadone for the treat...
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Case Reports Source Type: research

Screening, Brief Intervention, and Referral to Treatment in a Retail Pharmacy Setting: The Pharmacist's Role in Identifying and Addressing Risk of Substance Use Disorder
Conclusions: This study demonstrates the feasibility of performing SBIRT-based screenings in a retail pharmacy setting and combining these with PDMP-risk analysis to screen patients for prescription and illicit drug misuse. Findings from this study will inform the design of larger multisite studies, which should validate these findings and include follow-up analysis to assess the efficacy of intervention on this patient population. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Prescribing of Opioids and Benzodiazepines Among Patients With History of Overdose
Conclusions: In conclusion, prescribing of opioids and benzodiazepines occurs across multiple locations in a large health care system to patients with a previous overdose. Risk factors, such as previous overdose should be highlighted through clinical decision support tools in the medical record to help prescribers identify patients at higher risk and to mobilize resources for this patient population. Prescribers need further education on factors that place their patients at risk for opioid use disorder and on alternative therapies to opioids and benzodiazepines. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Medical Burden of Disease Among Individuals in Recovery From Alcohol and Other Drug Problems in the United States: Findings From the National Recovery Survey
Conclusions: Findings highlight the increased medical burden associated with AOD problems, and speak to the need for earlier and more sustained intervention for AOD problems, greater integration of addiction treatment and primary health care, and longitudinal research to explore the complex, dynamic relationships between AOD use and physical disease. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Evaluation of the Brief Alcohol Withdrawal Scale Protocol at an Academic Medical Center
Conclusions: Most patients on the BAWS protocol received little-to-no benzodiazepines; severe withdrawal, agitation, delirium, or over-sedation were uncommon. This is the first evaluation of the BAWS protocol on a diverse population of hospitalized patients. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Medication Adherence Monitoring Using Smartphone Video Dosing in an Open-label Pilot Study of Monthly Naltrexone Plus Once-daily Bupropion for Methamphetamine Use Disorder: Feasibility and Acceptability
Conclusions: The use of smartphones for video-based oral medication dosing in this study provided a feasible and acceptable mechanism to encourage, monitor, and confirm medication adherence. Video-confirmed dosing adherence provides an objective numerical indicator of the lowest medication adherence rate participants achieve, allowing investigators to more confidently interpret results. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Understanding the Family Planning Needs of Female Participants in a Syringe Exchange Program: A Needs Assessment and Pilot Project
Conclusions: WWID participating in this SEP may not prioritize their family planning needs when other health and safety needs are unmet. A pilot program to offer contraceptive injections at SEP had almost zero uptake. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Depressive Symptoms and Suicidality in Adolescents Using e-Cigarettes and Marijuana: A Secondary Data Analysis From the Youth Risk Behavior Survey
Conclusions: Youth with single and dual e-cigarette and marijuana use had increased odds of reporting depressive symptoms and suicidality compared to youth who denied use. There is a need for effective prevention and intervention strategies to help mitigate adverse mental health outcomes in this population. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Adverse Events During Treatment Induction With Injectable Diacetylmorphine and Hydromorphone for Opioid Use Disorder
Conclusions: A 3-day induction protocol allowed patients to safely reach high doses of injectable hydromorphone and diacetylmorphine in a timely manner. These findings suggest that safety is not an evidence-based barrier to the implementation of treatment with injectable hydromorphone and diacetylmorphine. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Severity of Analgesic Dependence and Medication-overuse Headache
Conclusions: MOH has characteristics of substance dependence which should be taken into account when choosing treatment strategy. Trial registration: Based on data collected in previously reported randomized BIMOH trial (Kristoffersen et al., 2012; Kristoffersen et al., 2015 in the present manuscript, Clinical trials registration number: NCT01314768). The present part, however, represents observational data and is not a treatment trial. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Patient and Physician Perspectives on Treating Tobacco Dependence in Hospitalized Smokers With Substance Use Disorders: A Mixed Methods Study
Conclusions: Inpatient addiction consultations represent a missed opportunity to counsel patients with substance use disorders to quit smoking. System-level changes are needed to coordinate treatment of tobacco and other drug dependence in hospitalized smokers. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Toward Gender-inclusive, Nonjudgmental Alcohol Interventions for Pregnant People: Challenging Assumptions in Research and Treatment
Epidemiological and clinical evidence clearly indicates that binge and/or heavy alcohol use while pregnant can be dangerous for the fetus. As such, there is a large body of research evaluating interventions to address harms associated with alcohol use during pregnancy. Unfortunately, based on our assessment of the scientific literature in this area, including a reading of three high-impact systematic reviews, there are several key areas where the language being used is hindering efforts to address alcohol harms during pregnancy in nonjudgmental and gender-inclusive ways. In this commentary, we describe four areas where int...
Source: Journal of Addiction Medicine - September 1, 2019 Category: Addiction Tags: Commentary Source Type: research

Use of Buprenorphine-Naloxone in the Treatment of Tianeptine Use Disorder
We presented a case of buprenorphine/naloxone successfully being used to aid in cessation and subsequent abstinence from tianeptine after years of use. An additional consideration with tianeptine use is the potential for the development or re-emergence of depression and anxiety on cessation. Chronic daily use of tianeptine may represent tianeptine use disorder, which can have a clinical course consistent with opioid use disorder, including the development of impaired control, functional impairment, tolerance, and withdrawal. It is appropriate to consider medications for opioid use disorder for the management of tianeptine ...
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Case Report Source Type: research

Pilot Trial of a Combined Cognitive Processing Therapy and Smoking Cessation Treatment
Conclusions: This pilot trial did not detect a difference in smoking cessation when combining CPT to smoking cessation treatment, relative to smoking cessation treatment without CPT. However, results suggest that combining CPT and smoking cessation treatment was associated with both reductions of psychiatric symptoms along with smoking abstinence rates similar to previous smoking cessation trials in veterans with PTSD. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Alcohol Drinking in Chinese Methadone-maintained Clients: A Self-medication for Depression and Anxiety?
This study examined the drinking pattern and its association with methadone dose, and depressive and anxiety symptoms in Chinese clients undergoing MMT. Methods: A secondary data analysis was conducted with data from a large-scale cross-sectional survey of 549 clients of 3 MMT clinics in Wuhan, China. Depression, anxiety, and alcohol dependence were measured with Zung Self-rating Depression Scale, Zung Self-rating Anxiety Scale, and Alcohol Dependence Scale, respectively. Drinking pattern was assessed using 3 indicators: weekly amount of alcohol consumed, weekly frequency of alcohol consumed, and severity of alcohol dep...
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Predictors for 30-Day and 90-Day Hospital Readmission Among Patients With Opioid Use Disorder
Objectives: To identify the incidence, characteristics, and predictors for 30 and 90-day readmission among acutely hospitalized patients with opioid use disorder (OUD). Methods: This retrospective, cohort study evaluated consecutive adults with OUD admitted to an academic medical center over a 5-year period (10/1/11 to 9/30/16). Multivariable logistic regression was used to determine independent predictors for 30 and 90-day readmissions based on pertinent admission, hospital, and discharge variables collected via chart review and found to be different (with a P  (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Recovery Goals and Long-term Treatment Preference in Persons Who Engage in Nonmedical Opioid Use
Conclusion: Public health initiatives to engage out-of-treatment individuals should take into account recovery goals and treatment preferences to maximize treatment initiation and retention. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Prevalence, Incidence, and Factors Associated With Substance Use Among Medical Students: A 2-Year Longitudinal Study
Conclusions: Our results indicate an increase in the incidence of lifetime substance use during medical training. Prior use of substance was associated with a higher chance of use after 2 years, while age and religiousness seem to reduce the chance of use. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Opioid and Cannabis Co-Use among Adults With Chronic Pain: Relations to Substance Misuse, Mental Health, and Pain Experience
Conclusions: These findings highlight a vulnerable population of polysubstance users with chronic pain, and indicates the need for more comprehensive assessment and treatment of chronic pain. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Technology Use Patterns Among Patients Enrolled in Inpatient Detoxification Treatment
Conclusions: Technology use patterns among this hard-to-reach sample of inpatient detoxification respondents suggest high rates of mobile phone ownership, TM use, and moderate use of technology to facilitate linkage to addiction treatment services. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Naloxone Availability and Pharmacy Staff Knowledge of Standing Order for Naloxone in Pennsylvania Pharmacies
Conclusions: Multiple barriers to naloxone access exist in pharmacies across a large, diverse state, despite the presence of a standing order to facilitate such access. Limited availability of naloxone in pharmacies, lack of knowledge or understanding by pharmacy staff of the standing order, and variability in out-of-pocket cost for this drug are among these potential barriers. Regulatory or legal incentives for pharmacies or drug manufacturers, education efforts directed toward pharmacy staff members, or other interventions may be needed to increase naloxone availability in pharmacies. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

“I didn’t want to be on Suboxone at first…” – Ambivalence in Perinatal Substance Use Treatment
Conclusions: Substance use treatment providers should consider the social consequences of medication treatment, as well as the clinical benefits, when presenting treatment options and recommendations to patients. Patient-centered care must include an understanding of larger social and structural contexts. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Obstetric and Pediatric Provider Perspectives on Mandatory Reporting of Prenatal Substance Use
Conclusions: Health care providers expressed concern about the targeted screening process used to identify women with substance use whose children are reported to child welfare authorities. Most providers believed that mandatory reporting processes could be modified in ways that would support the health of women and children. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Impact of Fentanyl Use on Buprenorphine Treatment Retention and Opioid Abstinence
Conclusions: Buprenorphine treatment retention and abstinence among those retained in treatment is not worse between people using fentanyl compared to heroin at treatment initiation. Both groups have lower abstinence rates at 6 months compared to individuals with negative toxicology at baseline. These findings suggest that people exposed to fentanyl still benefit from buprenorphine treatment. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Hospital-Based Addiction Medicine Healthcare Providers: High Demand, Short Supply
Substance use disorders account for a significant burden of disease and place an enormous strain on the health care system in the United States and beyond. Despite death tolls climbing, a myriad of evidence-based medications exist to effectively treat many substance use disorders including nicotine, alcohol, and opioid use disorders. To date, hospitals have largely been overlooked as a setting ripe for the delivery of specialized addiction care. This occurs despite a high lifetime prevalence of a substance use disorder (50%) occurring among hospitalized individuals. A potential barrier to this is the lack of addiction medi...
Source: Journal of Addiction Medicine - July 1, 2019 Category: Addiction Tags: Commentary Source Type: research

2019 ASAM Annual Conference Poster Abstracts
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - May 1, 2019 Category: Addiction Tags: Abstracts Source Type: research

Receipt of Substance Use Disorder Treatment Among Patients Visiting Psychiatrists
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - May 1, 2019 Category: Addiction Tags: Letter to the Editor Source Type: research

Loperamide-Associated Opioid Use Disorder and Proposal of an Alternative Treatment with Buprenorphine
This case report describes a patient with opioid use disorder who developed cardiac toxicity secondary to non-medical use of loperamide. At recommended doses, loperamide remains in the periphery to treat diarrhea. At high doses, loperamide causes central nervous system (CNS) opioid agonism. Complications of high-dose loperamide have been documented, including cardiotoxicity, and death. This is particularly important in light of the ongoing opioid epidemic. This case presents a patient with sequela of high-dose loperamide as an illicit opioid replacement and the subsequent loperamide toxicity, including significant QTc prol...
Source: Journal of Addiction Medicine - May 1, 2019 Category: Addiction Tags: Case Reports Source Type: research

Toxic Leukoencephalopathy Presenting as Lethal Catatonia
Discussion: Catatonia can develop in multiple psychiatric and somatic diseases, including toxic leukoencephalopathy. A biphasic course and specific MRI findings are characteristics for delayed toxic leukoencephalopathy, due to intoxication with drugs. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - May 1, 2019 Category: Addiction Tags: Case Reports Source Type: research

28-year-old Woman With Opioid Use Disorder Delivers Healthy Baby While in Custody: Addressing Forced Detox
Conclusions: The postpartum and postincarceration periods are 2 high-risk periods for women with OUD. OAT in and out of incarceration provided some stability and benefit, in the midst of a prenatal course that was fragmented by polysubstance use, hospitalization, and incarceration. Maintaining and prioritizing access to OAT for patients who are incarcerated is necessary, though not sufficient, to address the high risk of overdose. Empowering healthcare providers to advocate for incarcerated patients with OUD on an individual level is 1 key strategy to optimize addiction treatment for incarcerated people. (Source: Journal...
Source: Journal of Addiction Medicine - May 1, 2019 Category: Addiction Tags: Case Reports Source Type: research

Idiopathic Thrombocytopenic Purpura Induced by Synthetic Cannabinoid
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder defined as low platelet count with normal bone marrow in the absence of other causes of thrombocytopenia. It is caused by autoantibodies binding to several platelet surface antigens which lead to premature destruction of the platelet by the reticuloendothelial system. ITP can be primary or secondary, and it is known to be associated with various infections and drugs. K2/Spice, or synthetic marijuana, acts on cannabinoid receptors CB1 (cannabinoid type-1) and CB2 (cannabinoid type-2) with increased binding capacity compared to marijuana. A white male was br...
Source: Journal of Addiction Medicine - May 1, 2019 Category: Addiction Tags: Case Reports Source Type: research

Impact of In-utero Exposure to Selective Serotonin Reuptake Inhibitors and Opioids on Neonatal Opioid Withdrawal Syndrome
Conclusions: This study could not demonstrate a statistically significant difference in short-term NOWS outcome of LOT between the 2 groups. However, there was a trend towards longer LOT and LOS in the SSRI plus opioid group which could be clinically significant. A larger cohort may detect a true significant difference in these short-term outcomes. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - May 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Comparison of Perioperative Systemic Lidocaine or Systemic Ketamine in Acute Pain Management of Patients With Opioid Use Disorder After Orthopedic Surgery
In this study, we compared the effect of intraoperative lidocaine with ketamine in postoperative pain management of these patients. Design and Methods: In this randomized clinical trial, 180 patients with opioid use disorder who underwent orthopedic surgery under general anesthesia were randomly allocated into 3 groups. Patients in groups A, B, and C received intravenous lidocaine, ketamine, or normal saline, respectively, during the operation. Then, postoperative pain scores, analgesic requirements, patient satisfaction, and patient sleepiness were recorded and compared among the 3 groups. Results: Numerical rating ...
Source: Journal of Addiction Medicine - May 1, 2019 Category: Addiction Tags: Original Research Source Type: research

Drug Use-Related Normative Misperceptions and Behaviors Among Persons Seeking Heroin Withdrawal Management
Conclusions: Consistent with existing substance use norms research, participants in the current sample tended to overestimate others’ engagement in risky substance use, and these normative perceptions were associated with increased personal risk. Leveraging norms in heroin harm reduction interventions may hold substantial promise. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - May 1, 2019 Category: Addiction Tags: Original Research Source Type: research