The ASAM Clinical Practice Guideline on Alcohol Withdrawal Management: Erratum
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Erratum Source Type: research

Letter-in-Reply
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Letters to the Editor Source Type: research

Enhancing Training for Primary Care Physicians to Expand Addiction Medicine Services Beyond Specialty Care
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Letters to the Editor Source Type: research

Case Study: Naltrexone for the Treatment of Nitrous Oxide Use
We present here a case of a 41-year-old man with a substance use disorder for nitrous oxide who was reportedly using of up to four hundred 8 g canisters of nitrous oxide per day. Oral naltrexone was initiated at 50 mg daily in an attempt to decrease cravings. The dose was subsequently titrated to 100 mg daily, resulting in a decrease in nitrous oxide use to less than sixty 8 g canisters per week over a 1-month timeframe. Discussion: Previous literature surrounding naltrexone provides both a plausible mechanism of action for craving reduction as well as a precedent for its use across a number of substances. To ou...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

Transition From Methadone to Buprenorphine Using a Short-acting Agonist Bridge in the Inpatient Setting: A Case Study
We describe an inpatient transition from methadone to buprenorphine using a hydromorphone bridge over a 7-day period. This method used commonly available dosages and formulations of buprenorphine. To our knowledge, this is the first time a method has been described that transitions a patient from methadone to buprenorphine using a short-acting opioid agonist bridge and readily available opioid dosages and formulations. This case provides a viable alternative for rapidly transitioning a patient from methadone to buprenorphine that can be used as a template for an alternative method to transitions between these medications. ...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

Rapid Transition From Methadone to Buprenorphine Utilizing a Micro-dosing Protocol in the Outpatient Veteran Affairs Setting
Conclusions: This report provides a patient-centered approach demonstrating feasibility and cost-effectiveness of rapid transition to buprenorphine in the US outpatient psychiatry setting. Barriers to adherence to opioid agonist therapy may be reduced using this protocol. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

Non-medical Use of Naphazoline (Naphthyzin): Two Case Reports
The paper describes 2 case reports of non-medical use of Naphazoline (Naphthyzin). Both demonstrate that the peripherally acting alpha-adrenergic agonist Naphazoline obtains some addictive potential. The drug produces a feeling of euphoria, which resembles the perceived effects of psychostimulants. Both patients and people who consume Naphazoline for intoxication report increased tolerance after repeated use which indicates the addictive potential of the substance. To the best of our knowledge, this is the first examination of non-medical Naphazoline use and the first attempt to describe its addictive potential. Clinical p...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

A Case Report of Isopropanol Ingestion During the SARS-CoV-2 Pandemic
Conclusions: Toxic alcohol ingestions are imperative considerations on the differential for the intoxicated patient particularly during resource-limited times. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

HIV Treatment Initiation and Retention Among Individuals Initiated on Injectable Opioid Agonist Therapy for Severe Opioid Use Disorder: A Case Series
Conclusions: The individual cases presented suggest that among individuals with severe OUD and HIV infection, iOAT may improve HIV treatment uptake and retention in care. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

Prevalence of Covid-19 Infection and Subsequent Cohorting in a Residential Substance Use Treatment Program in Boston, MA
Conclusions: SARS-CoV-2 infection was common among staff and residents within a residential substance use treatment program for women in Boston. Universal SARS-CoV-2 testing in residential substance use programs can be instituted to reduce the risk of further transmission and continue addiction treatment programming when accompanied by adequate space, supplies, and staffing. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Brief Reports Source Type: research

Early Effects of COVID-19 on Programs Providing Medications for Opioid Use Disorder in Jails and Prisons
Conclusions: Jails and prisons with existing OAT programs have curtailed their operations in the context of the COVID-19 pandemic. Given the robust evidence base around OAT for treating opioid use disorder and averting overdose deaths, guidance is needed on maintaining and ramping up medication access as carceral facilities grapple with implementing COVID-19 mitigation. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Brief Reports Source Type: research

Relationship Between Alcohol-related Family Adversity, Alcohol Use Across Adolescence, and Mental States Recognition in Young Adulthood
Conclusions: Findings indicate that history of childhood adversity may actually improve young adult negative and neutral mental states recognition among those demonstrating high levels of risky alcohol use, as substance use may serve as an external self-regulatory tool. Clinical interventions that target enhancing metacognitive competence and emotion regulation could ultimately help to break the cycle of alcohol-related family adversity. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Assessing the Predictive Validity of the Stages of Change Readiness and Treatment Eagerness Scale (SOCRATES) in Alaska Native and American Indian People
Conclusions: Higher scores on the Taking Steps and Recognition subscales of the SOCRATES at baseline among ANAI people predicted lower mean EtG values. This study has important implications for communities and clinicians who need tools to assist ANAI clients in initiating behavior changes related to alcohol use. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Recovery From Opioid Use Disorder (OUD) After Monthly Long-acting Buprenorphine Treatment: 12-Month Longitudinal Outcomes From RECOVER, an Observational Study
Conclusions: RECOVER participants reported positive outcomes over the 12-month observational period, including high opioid abstinence and stable or improved humanistic outcomes. These findings provide insights into the long-term impact of pharmacotherapy in OUD recovery. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Factors Associated With the Use of Supervised Consumption Facilities Among Women Who Inject Drugs in a Canadian Setting
Conclusions: The current study demonstrates higher intensity patterns of drug use, including daily heroin and crystal methamphetamine injection, injecting in public and binge injection, as well as homelessness to be associated with SCF use among women. Future research should identify barriers to SCF use among women to minimize the risk of overdose and other drug-related harms. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Naloxone Training From Nonmedical Personnel: Benefits Before, During, and After Overdose Events
Conclusions: The results of the current study substantiate the effectiveness of naloxone in reversing overdose symptoms. A brief, 15-minute naloxone training delivered by nonmedical personnel enhanced overdose knowledge and led to positive reversal outcomes. Training persons who use opioids in dyads may offer additional benefits and improve follow-up reporting. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Associations Among Childhood Household Dysfunction, Sexual Orientation, and DSM-5 Alcohol, Tobacco and Other Substance Use Disorders in Adulthood: Evidence From a National U.S. Survey
Conclusions: Sexual minorities are more likely to have childhood household dysfunction which in turn is associated with a higher risk of developing DSM-5 alcohol, tobacco, and substance use disorders in adulthood, especially among sexual minority women. Healthcare providers who care for individuals raised in dysfunctional households should carefully assess risk for substance use disorders and intervene as needed. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Canadian Cannabis Consumption and Patterns of Congenital Anomalies: An Ecological Geospatial Analysis
Objectives: Cannabis is a known teratogen. Data availability addressing both major congenital anomalies and cannabis use allowed us to explore their geospatial relationships. Methods: Data for the years 1998 to 2009 from Canada Health and Statistics Canada was analyzed in R. Maps have been drawn and odds ratios, principal component analysis, correlation matrices, least squares regression and geospatial regression analyses have been conducted using the R packages base, dplyr, epiR, psych, ggplot2, colorplaner and the spml and spreml functions from package splm. Results: Mapping showed cannabis use was more common in...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Secondary Analysis of Pain Outcomes in a Large Pragmatic Randomized Trial of Buprenorphine/Naloxone Versus Methadone for Opioid Use Disorder
Conclusion and Relevance: In this large multisite randomized trial of medication treatments for OUD, nearly half of the participants reported pain at baseline, and improvement in pain early in treatment was associated with increased likelihood of retention in treatment. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

The Parental Experience of Newborns With Neonatal Abstinence Syndrome Across Inpatient Care Settings: A Qualitative Study
Conclusion: The parental experience of care for NAS is negatively affected by lack of standardized NAS education in the prenatal and postnatal settings, inconsistent communication with providers, the Finnegan scoring system, lack of provider sensitivity to parental substance use disorder, and maternal guilt. This study also highlights the parental desire to be more involved in the care of newborns with NAS. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Integrating Reproductive and Sexual Health Education and Services Into Opioid Use Disorder Treatment Programs: A Qualitative Study
Conclusions: Assessing determinants of implementation is important to the development of RSH interventions. CFIR constructs were found to be important influences that could facilitate or hinder effective implementation. Integration of RSH education and services is a process, and, when addressed in stages, might be feasible. A broad range of RSH education and services has the potential to have a profound impact on the health of women with OUD and their children, their families, and their communities. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Factors Associated With Cannabis Use Among African American Nondaily Smokers
Conclusions: Rates of cannabis and tobacco dual use in our sample exceed national rates. Dual use poses harmful health effects that exceed the risk of either substance alone. Findings will inform future work in tailoring treatments to vulnerable groups of people who use both tobacco and cannabis. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Association Between Patterns of Alcohol Use and Short-Term Risk of Suicide Attempt Among Patients With and Without Reported Suicidal Ideation
Conclusions: Findings underscore the potential value of offering alcohol-related care to patient reporting suicidal ideation. Additional strategies are needed to identify suicide risk among those reporting no suicidal ideation. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

The Clinical Significance of Food Addiction
Conclusions: Overall, this study replicates and extends previous findings, particularly in regard to behavioral economics and demand for food, providing further support for the consideration of food addiction in the psychiatric nosology. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Internal Medicine Residents’ Feelings of Responsibility, Confidence, and Clinical Practice in Opioid Overdose Prevention and Naloxone Prescribing
Conclusions: Despite feeling responsible and confident in addressing opioid overdose prevention strategies, few residents report implementing these strategies in clinical care. Residency programs must not only include curricula addressing overdose risk assessment and counseling, referral to or provision of OUD treatment, but also include curricula that impact implementation of opioid overdose prevention strategies. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

The Use of the Methadone/Metabolite Ratio (MMR) to Identify an Individual Metabolic Phenotype and Assess Risks of Poor Response and Adverse Effects: Towards Scientific Methadone Dosing
Conclusions: The MMR measures an individual's phenotype for methadone metabolism. The data suggested underdosing in the URM category, as well as evidence of excessive dosing in IM and USM categories. The MMR provides a guide to safe and effective dosing, an alternative to the pharmacokinetically ‘blind’ dosing algorithms currently in use. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Validation of the NIDA-modified ASSIST as a Screening Tool for Prenatal Drug Use in an Urban Setting in the United States
Conclusions: The NM-ASSIST reliably distinguished pregnant women who use cannabis from those who do not, but performed poorly for all other substances. More research is needed to identify screeners that reliably detect all prenatal drug use. Although more cost-prohibitive, a combination of self-report and toxicological screening may be preferable for detecting prenatal drug use. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Predictors of Opioid and Alcohol Pharmacotherapy Initiation at Hospital Discharge Among Patients Seen by an Inpatient Addiction Consult Service
Conclusions: The association of MOUD/MAUD initiation with homelessness and partner substance use suggests that hospitalization may be an opportunity to reach highly-vulnerable people, further underscoring the need to provide hospital-based addictions care as a health-system strategy. Methamphetamine's negative association with MOUD/MAUD warrants further study. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Time to First Cigarette: A Potential Clinical Screening Tool for Nicotine Dependence
Conclusions: Earlier TTFC is a key indicator of greater nicotine dependence. Knowledge of a smoker's TTFC may allow clinicians to accurately inform smokers of health risks and assign greater resources during cessation attempts. Smokers may be able to use TTFC to self-select cessation aids and accurately assess their unique smoking-related health risks. TTFC may be a better item than cigarettes/day for accurately quantifying dependence and risk in epidemiologic studies. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Avoiding NICU Transfers for Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS): A Quality Improvement Initiative to Manage NOWS on the Mother-baby Unit
Objectives: To reduce transfers to the neonatal intensive care unit (NICU) for neonates with opioid withdrawal while also reducing length of stay and pharmacologic intervention, and maintaining standards of safety. Patients and methods: This was a single-center quality-improvement (QI) initiative in a free-standing maternity hospital comparing outcomes for neonatal opioid withdrawal syndrome (NOWS) before and after a series of QI bundles in infants>36 weeks’ gestation age (GA). We compared outcomes to our preintervention period (January, 2013 to December, 2013; n = 42) with outcomes postintervention cycle...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Association Between E-cigarette Use and Depression in US Adults
Conclusion: In a representative sample of adults in the United States e-cigarette use is associated with depression, predominantly in widowed/divorced/separated, unemployed and people who use marijuana. This association was independent of potential cofounders. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Original Research Source Type: research

Executive Summary of the American Society of Addiction Medicine (ASAM) Clinical Practice Guideline on Alcohol Withdrawal Management
The American Society of Addiction Medicine (ASAM) Clinical Practice Guideline on Alcohol Withdrawal Management provides guidance on the identification and management of alcohol withdrawal in adults with varying degrees of syndrome severity. The guideline addresses both ambulatory and inpatient care and considers special patient populations. The Guideline was primarily developed following the RAND/UCLA Appropriateness Method (RAM), a process to determine the appropriateness of a set of clinical procedures. This process included a review of gray and empirical literature published between January 2012 and October 2017. Ninete...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Clinical Practice Guidelines Source Type: research

Overlapping Mechanisms of Recovery Between Professional Psychotherapies and Alcoholics Anonymous
Conclusions: In caring for patients with addiction, practicing clinicians will find it useful to be aware of overlapping analogous elements found in the AA program and professional psychotherapies and how they can complement one another. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Review Source Type: research

COVID-19 as a Frying Pan: The Promise and Perils of Pandemic-driven Reform
The imposition of new regulations can send industries scrambling to comply, fostering innovation in doing so. How we police and treat people with opioid use disorder (OUD), with recent widespread social unrest in reaction to police violence and systemic racism bringing the need for lasting structural changes to our justice system and social services into especially acute relief. Arbitrary laws and counterproductive policies previously subject to only incremental reform have given way to sweeping changes: people convicted of nonviolent drug crimes have been released from jails and prisons, the enforcement of drug laws has b...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Commentaries Source Type: research

Calls for Access to Safe Injecting Supplies as a Critical Public Health Measure During the COVID-19 Pandemic
More than 3 decades of research has provided compelling evidence regarding the effectiveness, safety, and cost-effectiveness of needle and syringe programs in reducing syringe-sharing and transmission of HIV, HCV, and other bloodborne infections. However, repressive drug policies and drug law enforcement practices around the world continue to undermine their operations and scale-up, as well as access to harm reduction among people who inject drugs. The COVID-19 pandemic has heightened access barriers to needle and syringe programs, raising concerns about unsafe injecting practices due to inadequate access to safe injecting...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Commentaries Source Type: research

Policies to Improve Substance Use Disorder Treatment With Telehealth During the COVID-19 Pandemic and Beyond
The COVID-19 pandemic has created an urgent need to expand access to substance use disorder (SUD) treatment through telehealth. A more permanent adoption of tele-SUD treatment options could positively alter the future of SUD treatment. We identify four steps that will help to ensure a broader transition to telehealth will be successful in improving the health outcomes of patients with SUDs. These steps are: (1) investing in telehealth infrastructure to enable health care providers and patients to use telehealth; (2) training and equipping providers to provide SUD treatment through telehealth; (3) providing patients with th...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Commentaries Source Type: research

A Call to Action to Combat the Opioid Epidemic Among Women
Acknowledging the needs and challenges of women with opioid use disorder is an essential step to reduce the opioid epidemic in the United States. Efforts that can help women include increasing psychosocial services to address trauma, increasing access to medication treatment for opioid use disorder, reducing barriers and stigma that impede access to and retention on treatment, and addressing structural and policy barriers. This commentary discusses the reasons why women-focused treatment for opioid use disorder is necessary and makes specific recommendations for interventions, treatment, services, and policies that can red...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Commentaries Source Type: research

Potential for Precision Medicine in Methadone Treatment of Opioid Use Disorder
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Commentaries Source Type: research

The Value of Experimental Support for the Acceptance of Alcoholics Anonymous by Clinicians
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Commentaries Source Type: research

Where is the Science? A Critical Interrogation of How Sex and Gender are Used to Inform Low-Risk Alcohol Use Guidelines
Across the globe, many countries publish low-risk alcohol guidelines which outline the recommended best practices for drinking limits to reduce the health risks and harms associated with excessive alcohol use. Frequently, low-risk drinking guidelines include different recommendations for cisgender men and women. As researchers working in the area of trans-inclusive substance use treatment and care, we are interested in the rationale for how gender-based low-risk drinking guidelines are determined, including the role of evidence and science. We argue that low-risk drinking guidelines based on sex and/or gender are highly in...
Source: Journal of Addiction Medicine - September 1, 2020 Category: Addiction Tags: Commentaries Source Type: research

Prenatal Opioid Exposure Research: Shortcomings and Solutions
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2020 Category: Addiction Tags: Letters to the Editor Source Type: research

Letter-in-reply
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2020 Category: Addiction Tags: Letters to the Editor Source Type: research

Decisions to Use Lofexidine or Clonidine
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2020 Category: Addiction Tags: Letters to the Editor Source Type: research

Preliminary Results of Psychiatric Inpatients Referred to an Addiction Medicine Consult Service
No abstract available (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2020 Category: Addiction Tags: Letters to the Editor Source Type: research

Low Barrier Tele-Buprenorphine in the Time of COVID-19: A Case Report
Conclusions: COVID-19-related regulatory changes allow buprenorphine initiation via telemedicine. We describe 2 cases where telemedicine was combined with street outreach to connect patients experiencing homelessness with OUD to treatment. These cases highlight an important opportunity to provide access to life-saving OUD treatment for vulnerable patients in the setting of a pandemic that mandates reduced face-to-face clinical interactions. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

Long-term Dextromethorphan Use and Acute Intoxication Results in an Episode of Mania and Autoenucleation
The pharmacologic and neuropsychiatric sequelae of long-term dextromethorphan use and acute dextromethorphan intoxication are reviewed in this case report. Dextromethorphan ingestion at the high end of toxicity, although rare, can cause violence to oneself and others, even in those previously without any history of such behaviors. In this article, the neuropsychiatric consequences of dextromethorphan toxicity are highlighted in a case report of a 37-year-old woman who had been using dextromethorphan for 5 years. She presented to a large urban emergency department in a psychotic and manic state after attempting autoenucleat...
Source: Journal of Addiction Medicine - July 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

Nalmefene in the Treatment of Internet Pornography Addiction – A Case Report and Review of Literature
The mu-opioid antagonist nalmefene (18 mg per day) was administered in the treatment of a heterosexual male with internet pornography addiction. The patient had no other co-addictions or psychiatric comorbidities, allowing a direct measurement for the effectiveness of nalmefene on internet pornography addiction. Over a period of 72 weeks and an assessment frequency between 1 and 18 weeks, self-monitoring assessments of craving and pornography consumption were collected on different craving and obsessive-compulsive scales. Results indicate that nalmefene impressively decreased addictive symptoms. Importantly, the patient-...
Source: Journal of Addiction Medicine - July 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

Sustained-release Oral Hydromorphone for the Treatment of Opioid Use Disorder
We present a case of a patient with OUD who was successfully switched and managed on oral hydromorphone after development of a prolonged QTc interval on methadone. Case: A 51-year-old man with longstanding polysubstance use presented to an urban hospital in Vancouver, Canada, for management of alcohol intoxication and hyponatremia. At the time of admission, the patient was stable on 100 mg of methadone daily, but was found to have a persistently elevated QTc (>550 milliseconds), putting him at increased risk for Torsades de Pointes. In an effort to find an alternative opioid agonist therapy for maintenance, a tri...
Source: Journal of Addiction Medicine - July 1, 2020 Category: Addiction Tags: Case Reports Source Type: research

Mortality Among People With Opioid Use Disorder: A Systematic Review and Meta-analysis
Conclusions: Individuals with OUD carry a high risk of all-cause and overdose-specific mortality. Potentially modifiable risk factors, such as HIV and injection drug use, were predictive of mortality risk and are amenable to global efforts aiming to improve access to OUD treatment and targeted harm reduction efforts. (Source: Journal of Addiction Medicine)
Source: Journal of Addiction Medicine - July 1, 2020 Category: Addiction Tags: Original Research Source Type: research