Determination of the alcohol biomarker phosphatidylethanol 16:0/18:1 and 33 compounds from eight different drug classes in whole blood by LC-MS/MS
Publication date: Available online 24 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Benedicte Jørgenrud, Eline Skadberg, Julio de Carvalho Ponce, Håvard Furuhaugen, Thomas Berg (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 24, 2020 Category: Drugs & Pharmacology Source Type: research

Use of computed tomography to assess subcutaneous drug dispersion with recombinant human hyaluronidase PH20 in a swine model
Publication date: Available online 22 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Robert J. Connor, Darin M. Taverna, Karla Thrall, Michael J. LaBarre, David W. Kang (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 23, 2020 Category: Drugs & Pharmacology Source Type: research

Δ9-tetrahydrocannabinol: Drug discrimination abuse liability testing in female Lister Hooded rats: Trials, tribulations and triumphs
Publication date: Available online 21 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): S.S. Rowton, B.A. Rocha, I.E. Porter (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 21, 2020 Category: Drugs & Pharmacology Source Type: research

Caenorhabditis elegans as a possible model to screen anti-Alzheimer's therapeutics
Publication date: Available online 20 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Deepraj Paul, Sandhya Chipurupalli, Antony Justin, Kalpana Raja, Suresh K. Mohankumar (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 20, 2020 Category: Drugs & Pharmacology Source Type: research

Experimental model of congestive heart failure induced by transverse aortic constriction in BALB/c mice
Publication date: Available online 20 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Shahid Tannu, John Allocco, Melissa Yarde, Pancras Wong, Xiuying Ma (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 20, 2020 Category: Drugs & Pharmacology Source Type: research

Simultaneous determination of barbiturates, phenytoin and topiramate in hair by LC-MS/MS and application to real samples
Publication date: Available online 19 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Jihyun Kim, Junghyun Kim, Hyesun Yum, Moonhee Jang, Jongsook Rhee, Sangki Lee, Sang Beom Han (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 19, 2020 Category: Drugs & Pharmacology Source Type: research

Validation of steroid sulfates deconjugation for metabolic studies. Application to human urine samples
Publication date: Available online 17 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): D. Martinez-Brito, M.L. Notarianni, M. Iannone, X. de la Torre, F. Botrè (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 18, 2020 Category: Drugs & Pharmacology Source Type: research

Development of a method to determine cytochrome P450 1A2, 2C9, 2D6 and 3A4 activity sheep hepatic microsomes
Publication date: Available online 18 October 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Grace M. McBride, Jia Yin Soo, Tamara Varcoe, Janna L. Morrison, Michael D. Wiese (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 18, 2020 Category: Drugs & Pharmacology Source Type: research

Reprint of: Nonclinical species sensitivity to convulsions: An IQ DruSafe consortium working group initiative
Publication date: Available online 30 September 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Jamie K. DaSilva, Laura Breidenbach, Tracy Deats, Dingzhou Li, Kimberly Treinen, Theo Dinklo, Sophie Kervyn, Greet Teuns, Martin Traebert, Katja Hempel (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - October 2, 2020 Category: Drugs & Pharmacology Source Type: research

Novel microvascular endothelial model utilizing a collagen vitrigel membrane and its advantages for predicting histamine-induced microvascular hyperpermeability
Publication date: Available online 3 September 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Miaki Uzu, Toshiaki Takezawa (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - September 3, 2020 Category: Drugs & Pharmacology Source Type: research

Characterization of iCell cardiomyocytes using single-cell RNA-sequencing methods
Publication date: Available online 29 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Christina Schmid, Christian T. Wohnhaas, Tobias Hildebrandt, Patrick Baum, Georg Rast (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 30, 2020 Category: Drugs & Pharmacology Source Type: research

Is there a role for the no observed adverse effect level in safety pharmacology?
Publication date: Available online 29 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Tomas Mow, Ninette K. Andersen, Nils Dragsted, Anders B. Lassen, Morten Laursen, Alan S. Bass, Jean-Pierre Valentin, Carrie Markgraf, Simon Authier, Ted J. Baird, Siddhartha Bhatt, Martin Traebert, Derek J. Leishman, David Jones, Michael J. Curtis (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 30, 2020 Category: Drugs & Pharmacology Source Type: research

In vitro model using cytokine cocktail to evaluate apoptosis in Min6 pancreatic beta cells
Publication date: Available online 20 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Hemangee H. Damame, Sheetalnath B. Rooge, Rahul S. Patil, Akalpita U. Arvindekar (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 21, 2020 Category: Drugs & Pharmacology Source Type: research

Establishment of drug screening in human embryonic stem cells based on a high-content screening system
Publication date: Available online 19 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Yunfen Hua, Yongqin Wu, Xing Chun, Huarong Huang, Junyan Yan, Baowei Hu, Ming Zhang, Lifang Jin (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 20, 2020 Category: Drugs & Pharmacology Source Type: research

Revisiting the hERG safety margin after 20 years of routine hERG screening
Publication date: Available online 5 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Derek J. Leishman, Matthew M. Abernathy, Evan B. Wang (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 15, 2020 Category: Drugs & Pharmacology Source Type: research

Schiefer counter: An alternative method for clonogenic assay evaluation
Publication date: Available online 14 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): A.F. Santos, E.M. Schiefer, M.C. Atherino, J.C. Atherino, L.H. Negri, A.M. Weffort-Santos, A.R. Crisma, W.M. de Souza, K.B. Felipe (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 14, 2020 Category: Drugs & Pharmacology Source Type: research

Twenty years of safety pharmacology model validation and the wider implications of this to drug discovery
Publication date: Available online 14 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Michael K. Pugsley, Bisrat Bekele, Helene Griessel, Tessa de Korte, Simon Authier, Anne F. Grobler, Carrie G. Markgraf, Michael J. Curtis (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 14, 2020 Category: Drugs & Pharmacology Source Type: research

Revisiting the hERG safety margin after 20 years of routine hERG screening
Publication date: Available online 5 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Derek J. Leishman, Matthew M. Abernathy, Evan B. Wang (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 12, 2020 Category: Drugs & Pharmacology Source Type: research

Evaluation of urinary biomarkers for early detection of acute kidney injury in a rat nephropathy model
Publication date: Available online 7 August 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Kristina Kohl, Eva Herzog, Gerhard Dickneite, Sabine Pestel (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 12, 2020 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: July–August 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 104Author(s): (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - August 4, 2020 Category: Drugs & Pharmacology Source Type: research

A Bayesian approach to toxicological testing
Publication date: Available online 29 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): James C. Felli, Derek J. Leishman (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 30, 2020 Category: Drugs & Pharmacology Source Type: research

Translation of in vitro cannabinoid 1 receptor agonist activity to in vivo pharmacodynamic endpoints
Publication date: Available online 21 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Stephen Jenkinson, Susan M.G. Goody, Asser Bassyouni, Rhys Jones, Annie Otto-Bruc, Stephanie Duquennoy, Jamie K. DaSilva, Paul Butler, Andy Mead (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 21, 2020 Category: Drugs & Pharmacology Source Type: research

Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation
Publication date: Available online 12 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Eric I. Rossman, Frank Cools, Jason Cordes, Deborah Dhuyvetter, Jennifer M. Doyle, Gregory S. Friedrichs, Brian Guth, Moni B. Neradilek, Stanley T. Parish, Jennifer B. Pierson, Nayak Polissar, Hai-Ming Tang (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 12, 2020 Category: Drugs & Pharmacology Source Type: research

Dynamic features of cardiac vector as alternative markers of drug-induced spatial dispersion
Publication date: Available online 6 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Pablo Daniel Cruces, Drago Torkar, Pedro David Arini (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 7, 2020 Category: Drugs & Pharmacology Source Type: research

Inotropic Assessment in Engineered 3D Cardiac Tissues using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in the BiowireTM II Platform
Publication date: Available online 3 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Yusheng Qu, Nicole Feric, Isabella Pallotta, Rishabh Singh, Rooz Sobbi, Hugo M. Vargas (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 4, 2020 Category: Drugs & Pharmacology Source Type: research

Integration of mechanical conditioning into a high throughput contractility assay for cardiac safety assessment
Publication date: Available online 3 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Matthias Goßmann, Peter Linder, Ulrich Thomas, Krisztina Juhasz, Marta Lemme, Michael George, Niels Fertig, Elena Dragicevic, Sonja Stoelzle-Feix (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 4, 2020 Category: Drugs & Pharmacology Source Type: research

Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method
Publication date: Available online 3 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Mahnaz Maddah, Mohammad A. Mandegar, Keri Dame, Francis Grafton, Kevin Loewke, Alexandre J.S. Ribeiro (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 4, 2020 Category: Drugs & Pharmacology Source Type: research

Characterization of an i.p. D-galactose-induced cataract model in rats
Publication date: Available online 3 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Lei Zhong, Tao Wang, Ting Wang, Huanhuan Cheng, Juan Deng, Hui Ye, Weihua Li, Shiqi Ling (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 4, 2020 Category: Drugs & Pharmacology Source Type: research

Use of the Actiwatch-Mini® in dog safety studies as an early indicator for drug-induced behavioural changes
Publication date: Available online 3 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Frank Cools, Ivan Kopljar, Tekle Fetene, Herman Borghys (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 4, 2020 Category: Drugs & Pharmacology Source Type: research

Video-based assessment of drug-induced effects on contractile motion properties using human induced pluripotent stem cell-derived cardiomyocytes
Publication date: Available online 1 July 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Yoshiko Okai, Keiko Matsune, Kazunori Yamanaka, Toshikatsu Matsui, Emily Pfeiffer Kaushik, Kosuke Harada, Hiroshi Kohara, Akimitsu Miyawaki, Harushige Ozaki, Matthew Wagoner, Tadahiro Shinozawa (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - July 2, 2020 Category: Drugs & Pharmacology Source Type: research

Voltage-sensing optical recording: A method of choice for high-throughput assessment of cardiotropic effects
Publication date: Available online 21 June 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Stéphane Bedut, Ralf Kettenhofen, Jean-Marc D'Angelo (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 22, 2020 Category: Drugs & Pharmacology Source Type: research

A general procedure to select calibration drugs for lab-specific validation and calibration of proarrhythmia risk prediction models: An illustrative example using the CiPA model
Publication date: Available online 21 June 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Xiaomei Han, Mohammadreza Samieegohar, Bradley J. Ridder, Wendy W. Wu, Aaron Randolph, Phu Tran, Jiansong Sheng, Sonja Stoelzle-Feix, Nina Brinkwirth, Maria Giustina Rotordam, Nadine Becker, Søren Friis, Markus Rapedius, Tom A. Goetze, Tim Strassmaier, George Okeyo, James Kramer, Yuri Kuryshev, Caiyun Wu, David G. Strauss (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 21, 2020 Category: Drugs & Pharmacology Source Type: research

INSPIRE: A European training network to Foster research and training in cardiovascular safety pharmacology
Publication date: Available online 18 June 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Pieter-Jan D. Guns, Brian D. Guth, Stefan Braam, Georgios Kosmidis, Elena Matsa, Annie Delaunois, Vitalina Gryshkova, Sylvain Bernasconi, Harry Knot, Yair Shemesh, Alon Chen, Michael Markert, Miguel Fernandez, Damiano Lombardi, Céline Grandmont, Berta Cillero-Pastor, Ron M.A. Heeren, Wim Martinet, Jeanette Woolard, Matt Skinner (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 20, 2020 Category: Drugs & Pharmacology Source Type: research

Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment
Publication date: Available online 18 June 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Nina Brinkwirth, Kiyoshi Takasuna, Masafumi Doi, Nadine Becker, Alison Obergrussberger, Søren Friis, Hatsue Furukawa, Yuka Hasegawa, Takayuki Oka, Atsushi Ohtsuki, Niels Fertig, Sonja Stoelzle-Feix (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 20, 2020 Category: Drugs & Pharmacology Source Type: research

An improved two-step method for extraction and purification of primary cardiomyocytes from neonatal mice
Publication date: Available online 11 June 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Chengbao Li, Xuli Rong, Jing Qin, Sheng Wang (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 12, 2020 Category: Drugs & Pharmacology Source Type: research

Intrapulmonary inoculation of multicellular spheroids to construct an orthotopic lung cancer xenograft model that mimics four clinical stages of non-small cell lung cancer
Publication date: Available online 10 June 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Yingbo Huang, Yifan Lu, Mallika Vadlamudi, Shen Zhao, Melanie Felmlee, Roshanak Rahimian, Xin Guo (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - June 10, 2020 Category: Drugs & Pharmacology Source Type: research

Using a qPCR device to screen for modulators of ABC transporter activity: A step-by-step protocol
Publication date: Available online 28 May 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Luisa Möhle, Barbora Schwarzová, Markus Krohn, Sven Marcel Stefan, Jens Pahnke (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 30, 2020 Category: Drugs & Pharmacology Source Type: research

The application of electrophysiological methods to characterize AMPA receptors in dissociated adult rat and non-human primate cerebellar neurons for use in neuronal safety pharmacology assessments of the central nervous system
Publication date: Available online 25 May 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Loïs S. Miraucourt, Michael V. Accardi, Karen E. Asin, Michael K. Pugsley, Michael J. Curtis, Simon Authier (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 25, 2020 Category: Drugs & Pharmacology Source Type: research

Unraveling the mechanism and the risk behind seizure liability of lead compounds in a neuroscience project
Publication date: Available online 22 May 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Annie Delaunois, Michael V. Accardi, Véronique André, Simon Authier, François Bouzom, Simon Hebeisen, Yves Lamberty, Faiza Laredj, Karine Leclercq, Anne-Gaëlle Letombe, Marie-Luce Rosseels, Chiara Carla Rospo, Marie-Christine Tordeur, Jean-Pierre Valentin, Martyn Wood (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 22, 2020 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: May–June 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 103Author(s): (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 21, 2020 Category: Drugs & Pharmacology Source Type: research

Combined cSLO-OCT imaging as a tool in preclinical ocular toxicity testing: A comparison to standard in-vivo and pathology methods
Publication date: Available online 12 May 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Petr Soukup, Barbara Lenz, Bernd Altmann, Solveig Badillo, Elke-Astrid Atzpodien, Simon A. Pot (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 13, 2020 Category: Drugs & Pharmacology Source Type: research

A capillary electrophoresis based approach for the identification of anti-drug antibodies against camelid VHH biologics (Nanobodies®)
Publication date: Available online 7 May 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Derek Wiswell, Divas Neupane, Minchao Chen, Edward P. Bowman, Douglas Linn, Anandi Sawant, Alissa Chackerian, Shuli Zhang, Enrique Escandón (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 7, 2020 Category: Drugs & Pharmacology Source Type: research

Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs
Publication date: Available online 30 April 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Yevgeniya E. Koshman, Amanda S. Wilsey, Brandan M. Bird, Aimee L. Endemann, Sabine Sadilek, Jessica Treadway, Ruth L. Martin, James S. Polakowski, Gary A. Gintant, Scott W. Mittelstadt (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - May 1, 2020 Category: Drugs & Pharmacology Source Type: research

Comprehensive analysis of cardiac function, blood biomarkers and histopathology for milrinone-induced cardiotoxicity in cynomolgus monkeys
Publication date: Available online 28 April 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Katsuyoshi Chiba, Tomomichi Ishizaka, Yu Yoshimatsu, Kei Mikamoto, Yu Maeda, Takuma Iguchi, Makoto Shirai, Takashi Yamaguchi, Koichi Goto, Ken Sakurai, Satoshi Tamai, Hiroko Kataoka, Miki Hasegawa, Kazuhiko Mori (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - April 28, 2020 Category: Drugs & Pharmacology Source Type: research

A practical guide to secondary pharmacology in drug discovery
Publication date: Available online 14 April 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Stephen Jenkinson, Friedemann Schmidt, Lyn Rosenbrier Ribeiro, Annie Delaunois, Jean-Pierre Valentin (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - April 15, 2020 Category: Drugs & Pharmacology Source Type: research

RNA interference-mediated silencing of Kv7.2 in rat dorsal root ganglion neurons abolishes the anti-nociceptive effect of a selective channel opener
Publication date: Available online 8 April 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Markus Valdor, Anke Wagner, Heike Fischer, Viola Röhrs, Wolfgang Schröder, Gregor Bahrenberg, André Welbers, Henry Fechner, Jens Kurreck, Thomas M. Tzschentke, Thomas Christoph (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Host cell proteins induce inflammation and immunogenicity as adjuvants in an integrated analysis of in vivo and in vitro assay systems
Publication date: Available online 8 April 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Kyohei Yasuno, Eri Hamamura-Yasuno, Daisuke Nishimiya, Masako Soma, Masako Imaoka, Kiyonori Kai, Kazuhiko Mori (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - April 9, 2020 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: March–April 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 102Author(s): (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - March 12, 2020 Category: Drugs & Pharmacology Source Type: research

Insights into toxicology, safety pharmacology, and drug dependence testing: The performance and predictive values of nonclinical tests
Publication date: Available online 12 March 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): J.D. Suarez-Torres, C.E. Ciangherotti, F.A. Jimenez-Orozco (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - March 12, 2020 Category: Drugs & Pharmacology Source Type: research

Stability of ceftolozane in human plasma and dried blood spots: Implications for transport and storage
Publication date: Available online 12 March 2020Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Jens Martens-Lobenhoffer, Matthias Hinderhofer, Uwe Tröger, Stefanie M. Bode-Böger (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - March 12, 2020 Category: Drugs & Pharmacology Source Type: research