Murine models of psoriasis and its applications in drug development
Publication date: Available online 18 November 2019Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Tingting Luo, Yang Ma, Wei WeiAbstractPsoriasis is an autoimmune skin disease which characteristic of a well-demarcated, erythematous, raised lesion with silvery-white dry scale. Although the mechanism of psoriasis has not been fully understood so far, much progress has been made in understanding many of its complex potential mechanism, particularly the crucial role of the IL-23/Th17 axis. There are a large number of psoriasis models that reflect the complexity of the psoriasis mechanisms. In this revie...
Source: Journal of Pharmacological and Toxicological Methods - November 20, 2019 Category: Drugs & Pharmacology Source Type: research

A DNAzyme based knockdown model for Fragile-X syndrome in zebrafish reveals a critical window for therapeutic intervention
In this study, we have used a novel DNAzyme based approach to create a larval model of FXS in zebrafish with specific focus on the early developmental window.MethodsFmr1specific DNAzymes were electroporated into embryos to create theknockdown. Changes in RNA and protein levels of FMRP and relevant biomarkers were measured in the 0-7dpf window. Behavioral tests to measure anxiety, cognitive impairments and irritability in the larvae were conducted at the 7dpf stage. Drug treatment was carried out at various time points in the 0-7dpf window to identify the critical window for pharmacological intervention.ResultsThe DNAzyme b...
Source: Journal of Pharmacological and Toxicological Methods - November 15, 2019 Category: Drugs & Pharmacology Source Type: research

A fully validated simple new method for environmental monitoring by surface sampling for cytotoxics
Publication date: Available online 15 November 2019Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): E. Rossignol, M.B. Amiand, J. Sorrieul, J.M. Bard, C. Bobin-DubigeonAbstractA wipe sampling procedure followed by a simple ultra-performance liquid chromatography – tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for simultaneous quantification of six cytotoxic drugs: 5-fluorouracil (5FU), doxorubicin (DOXO), epirubicin (EPI), ifosfamide (IF), cyclophosphamide (CP) and gemcitabine (GEM), as surrogate markers for occupational exposure.After a solid-phase extraction of wipin...
Source: Journal of Pharmacological and Toxicological Methods - November 15, 2019 Category: Drugs & Pharmacology Source Type: research

Investigating the applicability of different amounts of solutions used in experiments, which performed in rat knee joints: Determining the optimal intraarticular injection volume
In conclusion, the injection volume for the knee joints of rats should not exceed the 30 μL for optimum efficiency. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models
DiscussionDependent on animal model, both histopathological and biochemical end-points differed between sampling sites in the liver. Based on these findings, we recommend that sample site location is highly standardized and properly reported in order to minimize potential sampling variation and to optimize reproducibility and meaningful comparisons of preclinical studies of NAFLD. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Corrigendum to “Derivation and presentation of formulas for drug concentrations in two-, three- and four-compartment pharmacokinetic models” [Journal of Pharmacological and Toxicological Methods 100 (2019) 106621]
Publication date: January–February 2020Source: Journal of Pharmacological and Toxicological Methods, Volume 101Author(s): Cyprian Świętaszczyk, Lars Jødal (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Refinement of the rodent pentylenetetrazole proconvulsion assay, which is a good predictor of convulsions in repeat-dose toxicology studies
DiscussionRisk assessment at an early stage of drug development supports candidate selection and, along that approach, the PTZ proconvulsion assay was proven to be a good predictor of convulsions in subsequent toxicology studies. It was also demonstrated that a relatively lower PTZ dose (60 mg/kg) improved the dose-response-curve of the positive control tested, decreased mortality overall and, therefore, contributes to refining this standard procedure for CNS safety evaluation. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Rat multicellular 3D liver microtissues to explore TGF-β1 induced effects
Publication date: Available online 13 November 2019Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Vincenzo Prestigiacomo, Anna Weston, Laura Suter-DickAbstractChronic liver damage can lead to fibrosis, encompassing hepatocellular injury, activation of Kupffer cells (KC), and activation of hepatic stellate cells (HSC). Inflammation and TGF-β1 are known mediators in the liver fibrosis adverse outcome pathway (AOP). The aim of this project was to develop a suitable rodent cell culture model for the investigation of key events involved in the development of liver fibrosis, specifically the response...
Source: Journal of Pharmacological and Toxicological Methods - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Improving prediction of torsadogenic risk in the CiPA in silico model by appropriately accounting for clinical exposure
Publication date: Available online 13 November 2019Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Derek J. LeishmanAbstractAny adverse event is reliant on three properties: the appropriate pharmacology to trigger the event, the appropriate exposure of compound, and intrinsic patient factors. Each alone is necessary but insufficient to predict the event. The Comprehensive in vitro Proarrhythmia Assessment (CiPA) initiative attempts to predict the risk of torsade de pointes (TdP) by focusing on an in-silico model with thresholds determined at modest multiples of the therapeutic exposure for the parent...
Source: Journal of Pharmacological and Toxicological Methods - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Erratum to “Derivation and presentation of formulas for drug concentrations in two-, three- and four-compartment pharmacokinetic models” [Journal of Pharmacological and Toxicological Methods 100 (2019), 106621]
Publication date: Available online 13 November 2019Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Lars Jødal (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of several immunoassays used in drugs of abuse screening: Assessment against gold standard methods and calculation of measurement uncertainty
ConclusionsThis study covered a fundamental gap in available knowledge by evaluating the performance of screening the current new generation of immunoassays methods for drugs of abuse in urine against gold standard methods. (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 12, 2019 Category: Drugs & Pharmacology Source Type: research

Resolving the reversed rate effect of calcium channel blockers on human induced pluripotent stem cell-derived cardiomyocytes and the impact on in vitro cardiac safety evaluation
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Haoyu Zeng, Jixin Wang, Holly Clouse, Armando Lagrutta, Frederick Sannajust (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 5, 2019 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: November–December 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 100Author(s): (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 5, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of in silico action potential modeling (AP-Predict) and the hiPSc-CM MEA assay in predicting drug-induced cardiotoxicity
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Shuya Wang, Patricia A. Valentine, Matthew J. Cato, Anthony Bahinski, Khuram W. Chaudhary (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of effects of moxifloxacin on QT, JTpeak and Tpe in conscious telemetered dogs and nonhuman primates
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Todd Wisialowski, William Gorczyca, Peter Harris (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

An in silico predictive model for TdP based on multiple ion channel inhibition
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Todd Wisialowski, Stephen Jenkinson, Mark Gosink (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Challenge for the in silico translation of Na channel blockade effects on human-ECG parameters
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Takashi Yoshinaga, Taeko Kubo, Keiichi Asakura, Yasuyuki Abe, Ryuuta Saitou, Takafumi Shirakawa, Yoshiyuki Furukawa, Takashi Ashihara (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Comparison of telemetry-derived activity generated from rodent cardiovascular studies with quantitative open field locomotor activity
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Vincent Bernardo, Cheryl Tyszkiewicz, Siddhartha Bhatt, Todd Wisialowski, Susan Goody (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Use of PK/PD modelling of nonclinical cardiovascular data to aid in ex vivo-to-in vivo and cross-species translation
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): William Gorczyca, Todd Wisialowski, Jennifer Colangelo (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Prediction of drug-effects on cardiac repolarization in humans: What can we learn from the past to refine our drug discovery strategies?
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Jean-Pierre Valentin, Jean-Michel Guillon, Peter K. Hoffman, Catherine Ortemann-Renon, John Koerner, Jennifer Pierson, Gary A. Gintant, James Willard, Matthew Skinner, Todd Wisialowski, Michael Pugsley (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Hypothermia-induced QTc prolongation in non-human primates; Why you should measure body temperature in cardiovascular safety studies
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Todd Wisialowski, Jason Cordes, Betty Pettersen, Declan Flynn (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of cardiovascular risk related to a monoclonal antibody mediated increase in vascular endothelial growth factor in conscious normal rats
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Kathy Derakhchan, Ruth Reeves, Dennis Keefe, Suezanne Parker, Galen Carey (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Concordance of Ion Channel, Cardiomyocyte, and Preclinical Species in Proarrhythmia Cardiac Safety Evaluation
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Emily P. Kaushik (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Moving from detection of cardiovascular liabilities to quantitative mechanistic understanding: Concepts, challenges and opportunities
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Amy Pointon, Michael G. Rolf (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Integrating efficacy and safety: Telemetry and echocardiography in a pig model of myocardial infarction
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Michael G. Rolf, Stuart Purbrick, Madeleine Antonsson, Frank Seeliger, Martin Billger (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Development and characterization of a nerve conduction model in anesthetized non-human primates as a tool to assess compound-dependent peripheral nervous system risk
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Theodore Detwiler, Christopher Regan, Hillary Regan, Gary Sitko, Frederick Sannajust (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Getting more from blood pressure signals: Use of pulse wave analysis (PWA) to enable greater insight to compound-dependent hemodynamic effects
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Christopher Regan, Hillary Regan, Patrick Fanelli, Frederick Sannajust (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Measurement of heart rate variability (HRV) and spontaneous baroreflex sensitivity (sBRS) provides valuable information on compound-dependent cardiovascular effects to enhance safety risk assessment
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Christopher Regan, Patrick Fanelli, Hillary Regan, Theodore Detwiler, Pierre Morissette, Shaun Gruver, Frederick Sannajust (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of clinically-relevant proarrhythmic ECG biomarkers in conscious beagle dogs using a newly developed multiple lead ECG telemetry implant
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Christopher Regan, Tom Delahanty, Robert Brockway, Patrick Fanelli, Hillary Regan, Theodore Detwiler, Shaun Gruver, Gary Miller, Frederick Sannajust (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Is the current non-clinical drug development safety paradigm effective for assessing cardiovascular liabilities?
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Brian Roche, John Ross, Carlos A. Obejero-Paz, James Kramer (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

A translational research approach for cardiovascular safety assessment at Janssen
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Ard Teisman, Ammel, Vijay Urmaliya, David J. Gallacher (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

A translational analysis: In vitro hiPSC cardiomyocytes to human phase I analysis for a set of reference compounds with different QT/TdP risk categories
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Karel Van Ammel, Vijay Urmaliya, Hua Rong Lu, Jutta Rohrbacher, Ivan Kopljar, Hanne Jansen, David J. Gallacher, Ard Teisman (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

A translational analysis: Cardiac ion channels and isolated rabbit left ventricular wedge in predicting CV safety risk
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Jutta Rohrbacher, Hanne Jansen, Karel Van Ammel, Hua Rong Lu, Vijay Urmaliya, Ard Teisman, David J. Gallacher (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Translational research: What can we learn from the predictability of anesthetized guinea-pig and dog models for cardiovascular safety findings in man?
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Hanne Jansen, Vijay Urmaliya, Karel Van Ammel, Henk van der Linde, Jutta Rohrbacher, Ard Teisman, David J. Gallacher (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

An integrated translational analysis summary: Prediction of HERG, isolated wedge preparation, anaesthetized guinea pig and dog towards phase I clinical data for drugs with different QT/TdP risk categories
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Vijay Urmaliya, Karel Van Ammel, Jutta Rohrbacher, Henk van der Linde, Hua Rong Lu, Hanne Jansen, David J. Gallacher, Ard Teisman (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of cardiac function after cardioplegic treatment in isolated rabbit hearts
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Ziva Arimura, BaoXi Gao, Mei Fang, Yusheng Qu, Hugo Vargas (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

New approach for neuropharmacology profile: In-situ real-time neuropharmacology monitoring by imaging technique using the molecularly imprinted polymers (MIPs) probe
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Takashi Inutsuka, Maya Okamoto, Yasuo Yoshimi (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

H3B-6545, a selective estrogen receptor covalent antagonist, prevents bone loss in ovariectomized Sprague-Dawley rats
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Amy H. Kim, Manav Korpal, Renee Hukkanen, Nathalie Rioux, Markus Warmuth, Peter Smith (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

The effect of DMSO on the contraction and relaxation of isolated thoracic aorta of the CRL:WI(Han) rat
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Jason D. Payseur, Xuejun Wu, Sandra L. Turner, Konuralp Bayrak, Anthony Bahinski, Eric I. Rossman (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Can cardiovascular liabilities be detected earlier in drug development? Assessing the translation of tyrosine kinase inhibitors from cardiomyocytes and isolated hearts to whole animal
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Jennifer Shaffer, John Ross, Carlos A. Obejero-Paz, Michelle Waines, Andrew Bruening-Wright, Brian Roche (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Assessment of multiple positive controls in the Langendorff isolated heart assay and how they translate to whole animal
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Tyler Ardrey, John Ross, Michelle Waines, Tyree Campbell, Pritesh Patel, Brian Roche (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Proof of concept comprehensive ex vivo neurological assay
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Lois Miraucourt, Michael Accardi, Hai Huang, Simon Authier (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Occurrence of spontaneous arrhythmias in freely moving non-treated healthy telemetered Sprague-Dawley rats
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Paula Juliana Brizuela de Seadi Pereira, Mylene Pouliot, Alison Easter, Claudia Harper, Annick Prefontaine, Lois Miraucourt, Wendy Tan, Mohamed Said Maghezzi, Rob Wallis, Simon Authier (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Dual effect of clonidine on QT interval duration and body temperature in cynomolgus monkeys: QT correction formula for changes in core body temperature
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Abdel-Ilah El Amrani, Hai Huang, Stephane Loriot, Francine El Amrani, Pramila Singh, Simon Authier, Roy Forster (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Validation of gluteus medius muscle electromyographic (EMG) recording by telemetry in socialized cynomolgus monkeys
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Christophe Bory, David Coquard, Olivier Boucheix, Stephane Baudet (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Cardiovascular assessments in juvenile monkeys using jacketed telemetry: Background data and the effects of heart rate on QT correction
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Nataliya Sadekova, Kevin Norton (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Telemetered left-ventricular pressure in Yucatan mini-pigs: Chronic evaluation in a novel genetic model of non-obstructed hypertrophic cardiomyopathy
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Beth Geist, Bradley L. Youngblood, Yukie Ueyama, Amanda LaRose, Robert Hamlin, Marc J. Evanchik, Carlos del Rio (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Evaluation of seizure liabilities of epileptogenic but non-convulsive agents in rats
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Simon Loiodice, Julien Modolo, Emilie Cayre, Anne-Sophie Denibaud, Bertrand Rion, Geoffrey Viardot, Philippe L'Hostis, Fabrice Wendling, Christophe Drieu La Rochelle (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

PhysioTel M-series telemetry is a viable alternative to jacketed telemetry for continuous cardiovascular data collection on toxicology studies
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): John Kremer, Kerry Kopelke, Alexandra Sielaff, Michael Taschwer, Jill Nichols (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research

Assessment of relative sensitivities of crossover and ascending-dose study designs for cardiovascular telemetry evaluation in cynomolgus monkeys
Publication date: September–October 2019Source: Journal of Pharmacological and Toxicological Methods, Volume 99Author(s): Mark E. Sheffield, Kelly Ashcroft-Hawley (Source: Journal of Pharmacological and Toxicological Methods)
Source: Journal of Pharmacological and Toxicological Methods - November 1, 2019 Category: Drugs & Pharmacology Source Type: research