Adjunctive Reboxetine for Schizophrenia: Meta-analysis of Randomized Double-blind, Placebo-controlled Trials
Conclusion Adjunctive reboxetine could be useful for attenuating antipsychotic-induced weight gain, but it was not effective in treating psychopathology including negative symptoms in schizophrenia. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 17, 2019 Category: Psychiatry Authors: Zheng, Wei Li, Xian-Bin Shi, Zhan-Ming Yang, Xin-Hu Cai, Dong-Bin Ng, Chee H. Ungvari, Gabor S. Liu, Wei-Jian Wu, Yu-Jie Wang, Yuan-Yuan Ning, Yu-Ping Xiang, Yu-Tao Tags: Original Paper Source Type: research

Roadmap for Routine Pharmacogenetic Testing in a Psychiatric University Hospital
This article describes a pilot study design aimed to combine clinical variables such as therapeutic drug monitoring, inflammatory and stress markers with static and variable genetic information of depressed patients to develop an algorithm that predicts treatment response, and tolerability using machine learning algorithms. Psychometric evaluation covers the Hamilton Depression Rating Scale, the Childhood Trauma Questionnaire, and adverse drug reactions. An in-depth (epi-)genetic assessment combines genome-wide gene association data with DNA methylation patterns of genes coding CYP enzymes along with a pharmacogenetic batt...
Source: Pharmacopsychiatry - June 11, 2019 Category: Psychiatry Authors: Menke, Andreas Weber, Heike Deckert, J ürgen Tags: Original Paper Source Type: research

8-Hydroxylation and Glucuronidation of Mirtazapine in Japanese Psychiatric Patients: Significance of the Glucuronidation Pathway of 8-Hydroxy-Mirtazapine
Discussion  The plasma concentration of 8-OH-MIR was as low as 1.42 nmol/L, whereas 8-OH-MIR-G had an approximate 59.50 times higher concentration than 8-OH-MIR, suggesting a significant role for hydroxylation of MIR and its glucuronidation in the Japanese population. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 3, 2019 Category: Psychiatry Authors: Shinozaki, Masataka Pierce, Jason Hayashi, Yuki Watanabe, Takashi Sasaki, Taro Komahashi-Sasaki, Hazuki Akiyama, Kazufumi Kato, Kazuko Inoue, Yoshimasa Tsuchimine, Shoko Yasui-Furukori, Norio Ozeki, Yuji Shimoda, Kazutaka Tags: Original Paper Source Type: research

Very Low Frequency of Drug Therapy of Alcohol Dependence in Germany – Analysis of Data of A Statutory Health Insurance
Pharmacopsychiatry DOI: 10.1055/a-0896-2757Acamprosate and naltrexone are medications of proven efficacy in the treatment of alcohol dependence. In order to investigate the prescription of these drugs in outpatient routine treatment in Germany (frequency of prescription, duration, medical specialty of prescribing physician), data of a large statutory health insurance were analyzed. Persons were included who were discharged from inpatient treatment with an alcohol-related disorder among their diagnoses during a one year observation period and with no diagnosed additional substance-related disorder (apart from nicotine- and ...
Source: Pharmacopsychiatry - May 27, 2019 Category: Psychiatry Authors: Scherbaum, Norbert Holzbach, R üdiger Stammen, Gunnar Kirchof, Ute Bonnet, Udo Tags: Letter to the Editor Source Type: research

Can Kampo and Dietary Supplement Address Unmet Need? – A Commentary on Tatsumi et al. and Hoffmann et al.
Pharmacopsychiatry DOI: 10.1055/a-0902-5145 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 23, 2019 Category: Psychiatry Authors: Tsuboi, Takashi Tags: Commentary Source Type: research

Pathological Concentration of C-reactive Protein is Correlated to Increased Concentrations of Quetiapine, But Not of Risperidone, Olanzapine and Aripiprazole in a Naturalistic Setting
Pharmacopsychiatry DOI: 10.1055/a-0869-8053 Introduction Infections can alter drug clearance, but the impact of inflammation-induced changes is still not well known. The aim of the investigation was to examine the effect of pathological C-reactive protein (CRP) values (≥0.5 mg/dL) and leukocyte count on the metabolism of 4 different atypical antipsychotics. Methods Steady-state serum concentrations of individual patients under therapy with risperidone (n=45), aripiprazole (n=30), olanzapine (n=24), and quetiapine (n=166) were retrospectively analyzed during a period of inflammation by Spearman’s Rho correla...
Source: Pharmacopsychiatry - March 26, 2019 Category: Psychiatry Authors: Scherf-Clavel, Maike Weidner, Anne Deckert, J ürgen Menke, Andreas Unterecker, Stefan Tags: Original Paper Source Type: research

Commercial Pharmacogenetic Tests in Psychiatry: Do they Facilitate the Implementation of Pharmacogenetic Dosing Guidelines?
Discussion Most commercial pharmacogenetic tests we examined are well-equipped to facilitate implementation of the majority of dosing guidelines relevant to psychiatry but are limited in their ability to facilitate implementation of the full spectrum of dosing guidelines currently available. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 21, 2019 Category: Psychiatry Authors: Fan, Mikayla Bousman, Chad A. Tags: Original Paper Source Type: research

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Pharmacopsychiatry 2019; 02 Article in Thieme eJournals: Table of contents  |  Congress (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 21, 2019 Category: Psychiatry Source Type: research

No Connection between Long-Term Lithium Treatment and Antithyroid Antibodies
Conclusion The results obtained showed no significant connection between long-term lithium treatment and antithyroid antibodies. In bipolar patients receiving lithium longitudinally, antithyroid antibodies can be associated with some indexes of thyroid function. However, they behave differently in male and female patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 7, 2019 Category: Psychiatry Authors: Kraszewska, Agnieszka Ziemnicka, Katarzyna Sowi ński, Jerzy Ferensztajn-Rochowiak, Ewa Rybakowski, Janusz K. Tags: Original Paper Source Type: research

Consider Role of Glutamatergic Habenula-projecting Globus Pallidus in OCD
Pharmacopsychiatry DOI: 10.1055/a-0835-6447Recently, in a review article in this journal, Vlček and colleagues described the putative role played by the glutamatergic system in obsessive-compulsive disorder (OCD) and how this might explain the effects of certain treatments. They describe a neuroanatomical model, which includes a specific role of the amygdala-hippocampus complex (AHC) and would complete the classic cortico-striatal-thalamo-cortical (CSTC) mechanism of OCD. The role of the AHC can perhaps be better understood when considering its ancient relationship to the rest of the forebrain of mammals. This leads to di...
Source: Pharmacopsychiatry - February 4, 2019 Category: Psychiatry Authors: Loonen, Anton J.M. Ivanova, Svetlana A. Tags: Letter to the Editor Source Type: research

Correlation Between Violence and Antipsychotic Dosage in Schizophrenia: A Secondary Analysis of The Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE) Dataset
Discussion Violence in schizophrenia is associated with poor illness course. Further studies focusing on violence in younger non-white individuals are warranted. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 22, 2019 Category: Psychiatry Authors: Tasmim, Samia Kolla, Nathan J. Dada, Oluwagbenga Bani-Fatemi, Ali De Luca, Vincenzo Tags: Original Paper Source Type: research

A Big Thank You to Our Reviewers in the Past Year!
Pharmacopsychiatry 2019; 52: 5-6 DOI: 10.1055/a-0821-0656 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 10, 2019 Category: Psychiatry Tags: Acknowledgment to Reviewers Source Type: research

The Efficacy of Tiapride and Carbamazepine Combination Therapy in Reducing Alcohol Withdrawal Symptoms: A Systematic Review and Meta-Analysis
Pharmacopsychiatry DOI: 10.1055/a-0795-3689The combination of tiapride (TIA) and carbamazepine (CBZ) as an alternative treatment option to benzodiazepines and clomethiazole has been investigated by several investigations. We performed a systematic review and meta-analysis to further explore the efficacy of this combination in order to render more definite answers whether this combination can be recommendable in the clinical practice. We systematically searched electronic databases including PubMed (MEDLINE), EMBASE, OVID, Cochrane, Google Scholar, and Scopus for human studies. Statistical homogeneity was checked by χ2 ...
Source: Pharmacopsychiatry - December 6, 2018 Category: Psychiatry Authors: Latifi, Sahar Messer, Thomas Tags: Review Source Type: research

Obituary for Professor Hinderk Meiners Emrich, MD PhD
Pharmacopsychiatry DOI: 10.1055/a-0760-2100 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - December 3, 2018 Category: Psychiatry Authors: Leweke, F. Markus Bleich, Stefan Schneider, Udo Tags: Obituary Source Type: research

The Associations Between CYP2D6 Metabolizer Status and Pharmacokinetics and Clinical Outcomes of Venlafaxine: A Systematic Review and Meta-Analysis
Conclusions CYP2D6 metabolizer status had significant influence on venlafaxine pharmacokinetics, but insufficient evidence demonstrated that CYP2D6 metabolizer status was associated with its therapeutic effects and overall rate of adverse events, which provided further evidence regarding the relationship between CYP2D6 metabolizer status and venlafaxine. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 28, 2018 Category: Psychiatry Authors: Lin, Xiao-Qian Wang, Ping Cai, Wen-Ke Xu, Gui-Li Yang, Mei Zhou, Meng-Di Sun, Mei He, Fang He, Gong-Hao Tags: Original Paper Source Type: research

Studies of Half-Lives of Long-Acting Antipsychotics are Needed
Pharmacopsychiatry DOI: 10.1055/a-0755-7692 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - October 22, 2018 Category: Psychiatry Authors: Schoretsanitis, Georgios Villasante-Tezanos, Alejandro G. de Leon, Jose Tags: Letter to the Editor Source Type: research

Comparing Schizophrenia Patients With a Predicted High/Low Risk of Nonresponse Receiving Treatment with Ziprasidone and Haloperidol: A Randomized-Controlled Study
Discussion An alarmingly high number of patients were at high risk of nonresponse to antipsychotic treatment. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 20, 2018 Category: Psychiatry Authors: Schennach, Rebecca Riedel, Michael Spellmann, Ilja Musil, Richard Obermeier, Michael J äger, Markus Bottlender, Roland Schmauss, Max Laux, Gerd M öller, Hans-Jürgen Tags: Original Paper Source Type: research

Augmentation of Pharmacotherapy by Sleep Deprivation with Sleep Phase Advance in Treatment-Resistant Depression
Discussion Our preliminary study demonstrated the efficacy of pharmacotherapy augmentation by TSD and SPA in half of the patients with TRD. The main biochemical factors related to clinical response included status of cortisol and increase in IL-10 and IL-1β levels. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 10, 2018 Category: Psychiatry Authors: Kurczewska, Ewa Ferensztajn-Rochowiak, Ewa Jasi ńska-Mikołajczyk, Anna Ch łopocka-Woźniak, Maria Rybakowski, J. K. Tags: Original Paper Source Type: research

Efficacy of Add-on Pregabalin in the Treatment of Patients with Generalized Anxiety Disorder and Unipolar Major Depression With an Early Nonresponse to Escitalopram: A Double-Blind Placebo-Controlled Study
This study tests the efficacy of pregabalin versus placebo as adjunctive treatment in patients with generalized anxiety disorder (GAD) comorbid with unipolar major depression (UMD) and with an early nonresponse to escitalopram. Methods This is a double-blind, placebo-controlled 8-week add-on study of pregabalin, 75–600 mg/day (n=31) versus placebo (n=29) on open-label escitalopram in outpatients meeting the DSM-IV-TR criteria for GAD and UMD. The main outcome measures were change from baseline to endpoint in total STAI-S, Trail-Making Test B (TMT-B) and the Center of Epidemiological Studies Depression Scale (C...
Source: Pharmacopsychiatry - August 31, 2018 Category: Psychiatry Authors: Fountoulakis, Konstantinos N Karavelas, Vangelis Moysidou, Stefania Mavridis, Dimitris Pastiadis, Konstantinos Petalidou, Nicole Nimatoudis, Ioannis Kasper, Siegfried Tags: Original Paper Source Type: research

Treatment Options for Insomnia in Schizophrenia: A Systematic Review
Conclusions Despite a very limited number of specific studies on this matter, all 4 studies have shown good benefit/risk ratios and reviewed options—melatonin, paliperidone, and eszopiclone—might represent valid options for residual insomnia in schizophrenia. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 30, 2018 Category: Psychiatry Authors: Oliveira, Pedro Coroa, Manuel Madeira, Nuno Tags: Review Source Type: research

Molecular Signatures of Lithium Treatment: Current Knowledge
Pharmacopsychiatry DOI: 10.1055/a-0650-4820Lithium (Li) is the key mood stabilizer in the prevention of mood recurrences and suicide in bipolar disorders. However, only one-third of patients become asymptomatic with Li treatment, and to date, no clinical markers can predict this response variability. Li is a multitargeting drug, complicating an understanding of its mechanisms of action. The present article reviews Li’s various biological effects, including those obtained in transcriptomic and epigenetic studies, in both humans and animal models. A molecular signature of the therapeutic response to Li is urgently requ...
Source: Pharmacopsychiatry - July 30, 2018 Category: Psychiatry Authors: Bellivier, Frank Marie-Claire, Cynthia Tags: Review Source Type: research

Algorithms For Treatment of Major Depressive Disorder: Efficacy and Cost-Effectiveness
In conclusion, research in MDD revealed that systematic and structured treatment procedures, the diligent assessment of response at critical decision points, and timely dose and treatment type adjustments make the substantial difference in treatment outcomes between algorithm-guided treatment and treatment as usual. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 9, 2018 Category: Psychiatry Authors: Bauer, Michael Rush, A. John Ricken, Roland Pilhatsch, Maximilian Adli, Mazda Tags: Review Source Type: research

70 Years of Research and 50 Years of Lithium Clinics: From Serendipity to Gold Standard in Mood Disorders
Pharmacopsychiatry DOI: 10.1055/a-0651-8119 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 9, 2018 Category: Psychiatry Authors: Bauer, Michael Tags: Editorial Source Type: research

A Novel Study Design to Systematically Explore the Impact of Trial Methodology on Psychopharmacological Treatment Outcome in Patients with Depression
Discussion The results of the proposed study design may have substantial consequences when it comes to how to best interpret the results of traditional randomized, double-blind, placebo-controlled trials in the acute treatment of major depressive disorder. Furthermore, they may lead to the implementation of new study designs that may be more suitable for assessing the effectiveness of new antidepressant compounds in everyday clinical practice. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Sour...
Source: Pharmacopsychiatry - July 5, 2018 Category: Psychiatry Authors: Severus, Emanuel Sauer, Cathrin Bauer, Michael Ostacher, Michael Anghelescu, Ion-George Tags: Original Paper Source Type: research

Evaluation of Myocardial Damage After Electroconvulsive Therapy: Analyses of High-Sensitive Cardiac Troponin I and N-Terminal pro-B-type Natriuretic Peptide
In conclusion, our small study did not find any evidence for myocardial damage due to ECT by measuring hsTnI, but an increase of NT-proBNP, whose clinical relevance could only be speculated, yet. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 2, 2018 Category: Psychiatry Authors: Kranaster, Laura Badst übner, Johanna Aksay, Suna Su Bumb, Jan Malte Suliman, Rayan Neumaier, Michael Sartorius, Alexander Tags: Letter to the Editor Source Type: research

Kampo, A Japanese Traditional Medicinal System for Psychiatric Conditions: A Narrative Review
Discussion This review summarizes the current knowledge on Kampo for psychiatric conditions, highlighting a paucity of data and a need for further good-quality evidence on these medications. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 25, 2018 Category: Psychiatry Authors: Tatsumi, Laina Suzuki, Takefumi Yamada, Kazuo Mimura, Masaru Uchida, Hiroyuki Tags: Review Source Type: research

Lithium Clinics in Berlin and Dresden: a 50-Year Experience
Pharmacopsychiatry DOI: 10.1055/a-0633-3450Although lithium’s serendipitous discovery as a medication for depression dates back more than 200 years, the first scientific evidence that it prevents mania and depression arose only in the 1960s. However, at that time there was a lack of knowledge about how to administer and monitor lithium therapy safely and properly. The lithium clinics in Dresden and Berlin were remarkably similar in their beginnings in the late 1960s regarding patient numbers and scientific expertise without being aware of one another due to the Iron Curtain separating Germany into a western and easte...
Source: Pharmacopsychiatry - June 14, 2018 Category: Psychiatry Authors: Felber, Werner Bauer, Michael Lewitzka, Ute M üller-Oerlinghausen, Bruno Tags: Review Source Type: research

Efficacy and Effectiveness of Lithium in the Long-Term Treatment of Bipolar Disorders: An Update 2018
Pharmacopsychiatry DOI: 10.1055/a-0627-7489For more than 40 years, lithium has been the gold standard in the long-term treatment of bipolar disorders. In the course of the last 15 years, other drugs have been approved in this indication and are widely used in clinical practice at the expense of lithium. New research from the last few years, however, indicates that lithium is still the first-line treatment in this indication. Against this background and lithium’s proven acute antimanic efficacy, we should perhaps be using lithium more regularly (in combination with an atypical antipsychotic, if necessary) right from t...
Source: Pharmacopsychiatry - June 13, 2018 Category: Psychiatry Authors: Severus, Emanuel Bauer, Michael Geddes, John Tags: Review Source Type: research

Happy 50th Anniversary, Lithium Clinics: The Perspective of a Long-Time User
Pharmacopsychiatry DOI: 10.1055/a-0606-5323 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 24, 2018 Category: Psychiatry Authors: Selo, Marylou Tags: Commentary Source Type: research

Discrepancies Between Nomenclature and Indications of Psychotropics
Conclusions Our results raise concerns regarding generic terminologies of “antipsychotics” and “antidepressants” since the conventional indication-based nomenclature does not fit well with the official indication. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 23, 2018 Category: Psychiatry Authors: Minami, Fusaka Zohar, Joseph Suzuki, Takefumi Koizumi, Teruki Mimura, Masaru Yagi, Gohei Uchida, Hiroyuki Tags: Original Paper Source Type: research

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Pharmacopsychiatry 2018; 03 Article in Thieme eJournals: Table of contents  |  Congress (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 9, 2018 Category: Psychiatry Source Type: research

Response to Agomelatine Treatment is Independent of Smoking Status and Dosage: Results From the AGOPSYCH Study
Discussion Agomelatine efficacy appears to be independent of dosage and smoking status, pointing toward mechanisms beyond mere dose-response relationships. Further research will be necessary to validate these findings. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 7, 2018 Category: Psychiatry Authors: Englisch, Susanne Jung, Hanna Sophie Lewien, Antje Becker, Anna Nowak, Ulrike Braun, Hanna Eisenacher, Sarah Thiem, Jascha Meyer-Lindenberg, Andreas Zink, Mathias Tags: Original Paper Source Type: research

Antisuicidal Effects in Mood Disorders: Are They Unique to Lithium?
Discussion Long-term treatment with lithium has growing evidence of suicide- and attempt-sparing effects, probably greater than with anticonvulsants or antidepressants; antipsychotics remain to be tested adequately. However, the ethical and scientifically adequate design and conduct of trials of treatments aimed at suicide prevention remain challenging and underdeveloped. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - April 19, 2018 Category: Psychiatry Authors: Tondo, Leonardo Baldessarini, Ross J. Tags: Review Source Type: research

Antidepressant Prescription and Risk of Lung Cancer: A Nationwide Case-Control Study
Discussion Antidepressant prescription was not associated with elevation of lung cancer incidence using a nationally representative sample. The elevated risk for lung cancer with bupropion at high doses may be a bias by indication and warrant longitudinal investigation. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - April 16, 2018 Category: Psychiatry Authors: Tsai, Chia-Jui Chiu, Wei-Che Chen, Chia-Ju Chen, Pau-Chung McIntyre, Roger S. Chen, Vincent Chin-Hung Tags: Original Paper Source Type: research

Peripheral Oxytocin Predicts Higher-Level Social Cognition in Men Regardless of Empathy Quotient
This study investigates whether healthy individuals with very high or very low levels of empathy differ in endogenous OT and whether OT plasma levels can predict performance in a mentalizing task. Methods 40 healthy men were included based upon their score above the 85th or below the 15th percentile of the empathy quotient inventory 1. Participants’ abilities to interpret social information was assessed via the Social Detection Task 2. Plasma OT levels were analyzed using enzyme immunoassay. Results OT plasma levels predicted mentalizing performance for more ambiguous social scenes (i. e., difficult items) for...
Source: Pharmacopsychiatry - March 28, 2018 Category: Psychiatry Authors: Deuse, Lisa Wudarczyk, Olga Rademacher, Lena Kaleta, Peter Karges, Wolfram Kacheva, Stella Gr ünder, Gerhard Lammertz, Sarah E. Tags: Original Paper Source Type: research

Genetics of Lithium Response in Bipolar Disorder
Discussion The identification of genetic factors associated with lithium response will be important for (1) better understanding of lithium’s mode of action and (2) development of a predictive model for optimization of long-term treatment of bipolar disorder. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 26, 2018 Category: Psychiatry Authors: Papiol, Sergi Schulze, Thomas G. Alda, Martin Tags: Review Source Type: research

Clozapine-Induced DRESS Syndrome: A Case Series From the AMSP Multicenter Drug Safety Surveillance Project
Pharmacopsychiatry DOI: 10.1055/a-0586-8983Drug reaction with eosinophilia and systemic symptoms (DRESS) is an infrequent, but severe, adverse drug-induced reaction which occurs due to massive T-cell stimulation resulting in cytotoxicity and eosinophil activation and recruitment. The incidence is 0.4 cases per 100, 0000 in the general population; the mortality rate is up to 10%. Therefore, we believe that recognizing this syndrome is of particular importance. The problem we notice is that DRESS is often seen and described in patients receiving rheumatologic or anticonvulsant drugs, but very rarely in psychiatric hospitals,...
Source: Pharmacopsychiatry - March 19, 2018 Category: Psychiatry Authors: Sanader, B. Grohmann, R. Gr ötsch, P. Schumann, T. Toto, S. Fernando, P. St übner, S. Tags: Letter to the Editor Source Type: research

Efficacy, Tolerability, and Safety of Blonanserin in Schizophrenia: An Updated and Extended Systematic Review and Meta-Analysis of Randomized Controlled Trials
Discussion The current meta-analytic study did not update the comparison of blonanserin vs. haloperidol because there were no new RCTs. Our results suggest that the efficacy of blonanserin for schizophrenia is comparable with that of other antipsychotics, and blonanserin seems to be well tolerated. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 7, 2018 Category: Psychiatry Authors: Kishi, Taro Matsui, Yuki Matsuda, Yuki Katsuki, Asuka Hori, Hikaru Yanagimoto, Hiroko Sanada, Kenji Morita, Kiichiro Yoshimura, Reiji Shoji, Yoshihisa Hagi, Katsuhiko Iwata, Nakao Tags: Review Source Type: research

Lithium: A Global Perspective
Pharmacopsychiatry DOI: 10.1055/a-0581-5100 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 7, 2018 Category: Psychiatry Authors: Malhi, Gin S Tags: Commentary Source Type: research

Comparative Efficacy and Safety of Antipsychotic Drugs for Tic Disorders: A Systematic Review and Bayesian Network Meta-Analysis
Conclusions Atypical antipsychotics (risperidone and aripiprazole) appear to be the most robust evidence-based options for the treatment of TDs. Quetiapine may be a promising therapy. Ziprasidone and olanzapine are also effective, but the evidence is lacking. Further high-quality directly comparing different pharmacological treatment studies are justified. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 5, 2018 Category: Psychiatry Authors: Yang, Chunsong Hao, Zilong Zhang, Ling-Li Zhu, Cai-Rong Zhu, Ping Guo, Qin Tags: Review Source Type: research

Impact of Chronic Cannabis Use on Auditory Mismatch Negativity Generation in Schizophrenia Patients
This study therefore examined the effects of CUD on MMN generation in SCZ patients. Methods Twenty SCZ − CUD patients, 21 SCZ+CUD patients, and 20 healthy controls (HC) were included in this study. MMN to frequency and duration deviants was elicited within an auditory oddball paradigm and recorded by 32 channel EEG. Results As expected, SCZ − CUD patients showed reduced frontocentral MMN amplitudes to duration deviants compared to HC. Interestingly, SCZ+CUD patients demonstrated greater MMN amplitudes to duration deviants compared to SCZ − CUD patients at central electrodes with no differences compared to...
Source: Pharmacopsychiatry - March 5, 2018 Category: Psychiatry Authors: Roser, Patrik Pichler, Eva-Maria Habermeyer, Benedikt Kawohl, Wolfram Juckel, Georg Tags: Original Paper Source Type: research

Lithium Treatment in Children and Adolescents
Discussion There is inadequate data about the full variety of benefit and tolerability of lithium treatment in pediatric patients. However, given the potential for protection against suicide and neurotoxic effects of illness, further studies should be a priority. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 28, 2018 Category: Psychiatry Authors: Duffy, Anne Grof, Paul Tags: Review Source Type: research

Combination of Metformin and Lifestyle Intervention for Antipsychotic-Related Weight Gain: A Meta-Analysis of Randomized Controlled Trials
Conclusion Combining metformin and lifestyle intervention shows significant effect in reducing AP-related weight gain. Higher quality and larger RCTs are needed to confirm these findings.Review registration: CRD42017059198 [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 27, 2018 Category: Psychiatry Authors: Zheng, Wei Zhang, Qing-E Cai, Dong-Bin Yang, Xin-Hu Ungvari, Gabor S. Ng, Chee H. Wu, Ren-Rong Xiang, Yu-Tao Tags: Original Paper Source Type: research

DNA Methylation Profiling in a Neuroblastoma Cell Line Exposed to the Antipsychotic Perospirone
Discussion Our comprehensive DNA methylation analyses will contribute to a better understanding of detailed pharmacological actions of perospirone. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 27, 2018 Category: Psychiatry Authors: Murata, Yui Bundo, Miki Sunaga, Fumiko Kasai, Kiyoto Iwamoto, Kazuya Tags: Original Paper Source Type: research

Response to Lithium in Patients with Bipolar Disorder: What are Psychiatrists ’ Experiences and Practices Compared to Literature Review?
This study aims at characterizing French psychiatrists’ opinions regarding definition criteria and factors associated with lithium prophylactic response in patients with bipolar disorders. Methods After a literature review, an online survey targeted French psychiatrists in 2016. Results Literature review showed inconsistencies in reported definition criteria and clinical predictors of lithium prophylactic response. A total of 104 psychiatrists, mostly working in hospitals, completed the survey. The inconsistencies regarding definition criteria and predictors of lithium response were confirmed. Five factors were commo...
Source: Pharmacopsychiatry - February 27, 2018 Category: Psychiatry Authors: Montlahuc, Claire Curis, Emmanuel Laroche, Diane Grillault Bagoe, G érald Etain, Bruno Bellivier, Frank Chevret, Sylvie Tags: Original Paper Source Type: research

QTc Time Correlates with Amitriptyline and Venlafaxine Serum Levels in Elderly Psychiatric Inpatients
Pharmacopsychiatry DOI: 10.1055/s-0044-102009 Introduction Many antidepressants cause QT prolongation but the classification of cardiac risk of these drugs varies markedly in different published lists. This retrospective study analyzed the correlation of QTc time with amitriptyline and venlafaxine serum level in elderly psychiatric inpatients. Methods Elderly inpatients aged≥65 years for whom venlafaxine or amitriptyline serum level had been measured were selected retrospectively from a therapeutic drug monitoring database and screened for an electrocardiogram measurement at the time of blood withdrawal. The correlation...
Source: Pharmacopsychiatry - February 21, 2018 Category: Psychiatry Authors: Hefner, Gudrun Hahn, Martina Hohner, Matthias Roll, Sybille C. Klimke, Ansgar Hiemke, Christoph Tags: Original Paper Source Type: research

What Does Antidepressant Drug level Monitoring Reveal About Outpatient Treatment and Patient Adherence?
Conclusion The results show that antidepressant nonresponders are frequently under-dosed or nonadherent. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 19, 2018 Category: Psychiatry Authors: Silhan, Petr Urinovska, Romana Kacirova, Ivana Hyza, Martin Grundmann, Milan Ceskova, Eva Tags: Original Paper Source Type: research

Intramuscular Testosterone Supplementation Ameliorates Depression in Hypogonadal Men: A Retrospective Study in an Outpatient Department
Pharmacopsychiatry DOI: 10.1055/s-0043-125214 Introduction Substantial evidence has indicated an association between hypogonadism and depressive symptoms, which led to the conduction of studies that found an ameliorating effect of testosterone (T) supplementation (S) upon depression in men. Methods Retrospective analysis of medical records identified 16 depressed, hypogonadal men who have not responded adequately to initial antidepressant therapy and subsequently received intramuscular T injections. Following the proposal of Button et al., a minimal clinically important difference was defined as an 18% reduction of the Bec...
Source: Pharmacopsychiatry - February 1, 2018 Category: Psychiatry Authors: Miclea, A. Miclea, M. Pistor, M. Stegmayer, K. Hoepner, R. Tags: Original Paper Source Type: research

A Big Thank You to Our Reviewers in the Past Year!
Pharmacopsychiatry 2018; 51: 7-8 DOI: 10.1055/s-0043-124712 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 1, 2018 Category: Psychiatry Tags: Acknowledgment to Reviewers Source Type: research

Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017
Pharmacopsychiatry 2018; 51: e1-e1 DOI: 10.1055/s-0037-1600991 [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 1, 2018 Category: Psychiatry Authors: Hiemke, C. Bergemann, N. Clement, H. W. Conca, A. Deckert, J. Domschke, K. Eckermann, G. Egberts, K. Gerlach, M. Greiner, C. Gr ünder, G. Haen, E. Havemann-Reinecke, U. Hefner, G. Helmer, R. Janssen, G. Jaquenoud, E. Laux, G. Messer, T. M össner, R. M Tags: Erratum Source Type: research