Anti-SARS-CoV-2 Action of Fluvoxamine may be Mediated by Endothelial Nitric Oxide Synthase
Pharmacopsychiatry DOI: 10.1055/a-1641-0357 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 23, 2021 Category: Psychiatry Authors: Papadopoulos, Konstantinos I. Sutheesophon, Warachaya Aw, Tar-Choon Tags: Letter to the Editor Source Type: research

Baseline Working Memory Predicted Response to Low-Dose Ketamine Infusion in Patients with Treatment-Resistant Depression
Pharmacopsychiatry DOI: 10.1055/a-1589-6301 Introduction Pretreatment neurocognitive function may predict the treatment response to low-dose ketamine infusion in patients with treatment-resistant depression (TRD). However, the association between working memory function at baseline and the antidepressant efficacy of ketamine infusion remains unclear. Methods A total of 71 patients with TRD were randomized to one of three treatment groups: 0.5 mg/kg ketamine, 0.2 mg/kg ketamine, or normal saline. Depressive symptoms were measured using the 17-item Hamilton Depression Ra...
Source: Pharmacopsychiatry - September 16, 2021 Category: Psychiatry Authors: Chen, Mu-Hong Lin, Wei-Chen Li, Cheng-Ta Tsai, Shih-Jen Wu, Hui-Ju Bai, Ya-Mei Hong, Chen-Jee Tu, Pei-Chi Su, Tung-Ping Tags: Original Paper Source Type: research

Impact of Psychiatric and Related Somatic Medications on the Duration and Severity of COVID-19: A Retrospective Explorative Multi-center Study from the German Metropolitan Ruhr-area
Discussion None of the tested medications was significantly associated with the COVID-19-duration and -severity up to the end of post-diagnosing week 3. However, there were a few biologically plausible and promising relationships with antidepressants, anticoagulants, and RAAS-inhibitors before p-value adjustment. These should encourage larger and prospective studies to re-evaluate the influence of somatic and psychiatric routine medications on COVID-19-related health outcomes. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table o...
Source: Pharmacopsychiatry - September 16, 2021 Category: Psychiatry Authors: Bonnet, Udo Claus, BenediktBernd Schaefer, Martin Kuhn, Jens Nyhuis, Peter Scherbaum, Norbert Br üne, Martin Wakili, Velat Juckel, Georg Tags: Original Paper Source Type: research

COVID-19: Risks, Complications, and Monitoring in Patients on Clozapine
We present an overview of relevant editorials, observational studies, and case studies, in which COVID-19 was reported in patients on clozapine. Patients using clozapine may have a higher risk of infection than patients with schizophrenia spectrum disorders (SSD) using other antipsychotics. SARS-CoV-2 infection can result in a dangerous increase of clozapine plasma levels, and granulocytopenia and lymphocytopenia (generally mild and short-term) may also occur, usually not as a result of clozapine treatment. Clozapine intoxication, pneumonia and delirium are the main complications of COVID-19 in patients on clozapine. In or...
Source: Pharmacopsychiatry - September 1, 2021 Category: Psychiatry Authors: Veerman, Selene R. T. Bogers, Jan P. A. M. Cohen, Dan Schulte, Peter F. J. Tags: Review Source Type: research

Expression Biomarkers of Pharmacological Treatment Outcomes in Women with Unipolar and Bipolar Depression
Conclusion Based on transcriptomic profiling, we identified potential expression biomarkers of treatment outcomes for UD and BD. We also proved that the Ras-GEF pathway associated with long-term memory, female stress response, and treatment response modulation in animal studies impacts treatment efficacy in patients with BD. Further studies focused on the outlined genes may help provide predictive markers of treatment outcomes in UD and BD. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  ...
Source: Pharmacopsychiatry - September 1, 2021 Category: Psychiatry Authors: Dmitrzak-Weglarz, Monika Szczepankiewicz, Aleksandra Rybakowski, Janusz Kapelski, Pawe ł Bilska, Karolina Skibinska, Maria Reszka, Edyta Lesicka, Monika Jablonska, Ewa Wieczorek, Edyta Pawlak, Joanna Tags: Original Paper Source Type: research

Digital Phenotyping and Mobile Sensing in Addiction Psychiatry
Pharmacopsychiatry DOI: 10.1055/a-1559-4003 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 18, 2021 Category: Psychiatry Authors: Liu, Shuyan Heinzel, Stephan Dolan, Raymond J. Tags: Letter to the Editor Source Type: research

Candidate Psychotropics against SARS  – CoV – 2: A Narrative Review
Pharmacopsychiatry DOI: 10.1055/a-1551-3756Since few therapeutic options are clinically accessible for coronavirus disease 2019 (COVID-19), effective, safe, and globally available pharmaceuticals need to be urgently developed to prevent severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and alleviate the severity of COVID-19. In this regard, the present paper is intended to provide an extensive review of the clinical and preclinical evidence on the psychotropics’ anti-SARS-CoV-2 effects, giving an insight into their potential applications for patients with a proven or high likelihood of COVID-19 pne...
Source: Pharmacopsychiatry - August 16, 2021 Category: Psychiatry Authors: Khosravi, Mohsen Tags: Review Source Type: research

Effect of Quetiapine, from Low to High Dose, on Weight and Metabolic Traits: Results from a Prospective Cohort Study
Pharmacopsychiatry DOI: 10.1055/a-1525-2820 Introduction The atypical antipsychotic quetiapine is known to induce weight gain and other metabolic complications. The underlying mechanisms are multifactorial and poorly understood with almost no information on the effect of dosage. Concerns were thus raised with the rise in low-dose quetiapine off-label prescription (i. e.,
Source: Pharmacopsychiatry - August 13, 2021 Category: Psychiatry Authors: Dubath, C éline Piras, Marianna Gholam, Mehdi Laaboub, Nermine Grosu, Claire Sentissi, Othman Gamma, Franziska Solida, Alessandra von Gunten, Armin Conus, Philippe Eap, Chin B. Tags: Original Paper Source Type: research

Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures: An Analysis of Online Psychedelic Experience Reports
This study analyzed reports of classic psychedelics administered with mood stabilizers from 3 websites (Erowid.org, Shroomery.org, and Reddit.com). Results Strikingly, 47% of 62 lithium plus psychedelic reports involved seizures, and an additional 18% resulted in bad trips while none of 34 lamotrigine reports did. Further, 39% of lithium reports involved medical attention. Most of the lamotrigine reports (65%) but few (8%) of the lithium reports were judged to not affect the psychedelic experience. Discussion Although further research is needed, we provisionally conclude that psychedelic use may pose a significant seizure ...
Source: Pharmacopsychiatry - August 4, 2021 Category: Psychiatry Authors: Nayak, Sandeep M. Gukasyan, Natalie Barrett, Frederick S. Erowid, Earth Erowid, Fire Griffiths, Roland R. Tags: Original Paper Source Type: research

An Oppositional Tolerance Account for Potential Cognitive Deficits Caused by the Discontinuation of Antidepressant Drugs
We present a novel framework based on the idea of allostatic adaptation, which allows to predict how different antidepressants likely impair different cognitive processes as a result of withdrawal and rebound effects. This framework relies on the assumptions that the type of cognitive impairments evoked by an antidepressant is determined by the targeted neurotransmitter systems, while the severity of deficits depends on its half-life. Our model predicts that the severity of detrimental cognitive withdrawal and rebound effects increases with a shorter half-life of the discontinued antidepressant drug. It further proposes dr...
Source: Pharmacopsychiatry - July 22, 2021 Category: Psychiatry Authors: Colzato, Lorenza Zhang, Wenxin Walter, Henrik Beste, Christian Stock, Ann-Kathrin Tags: Review Source Type: research

Drug-drug Interactions between COVID-19 Treatments and Antidepressants, Mood Stabilizers/Anticonvulsants, and Benzodiazepines: Integrated Evidence from 3 Databases
Conclusions Clinicians prescribing antidepressants, mood stabilizers/anticonvulsants, and benzodiazepines, should be aware of the probable risk of drug-drug interaction with COVID-19 medications and may benefit from heeding these recommendations for use to ensure patient safety. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 25, 2021 Category: Psychiatry Authors: Plasencia-Garc ía, Beatriz Oda Rico-Rangel, Mar ía Isabel Rodr íguez-Menéndez, Gonzalo Rubio-Garc ía, Ana Torell ó-Iserte, Jaime Crespo-Facorro, Benedicto Tags: Review Source Type: research

Psychedelics: A New Treatment Paradigm in Psychiatry?
Pharmacopsychiatry DOI: 10.1055/a-1520-5020The renaissance of psychedelics has accelerated further over the past year. At least that’s true if you follow the public press. The New York Times recently titled “The Psychedelic Revolution Is Coming. Psychiatry May Never Be the Same.” on its front page 1. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 24, 2021 Category: Psychiatry Authors: Gr ünder, Gerhard Tags: Editorial Source Type: research

The Potential Role of Psychedelic Drugs in Mental Health Care of the Future
Pharmacopsychiatry DOI: 10.1055/a-1486-7386Serotonergic psychedelics such as psilocybin, lysergic acid diethylamide (LSD), or dimethyltryptamine (DMT), as well as psychoactive drugs that trigger phenomenologically- related experiences like 3,4-methylenedioxymethamphetamine (MDMA) and ketamine, belong to the most promising treatment approaches in contemporary psychiatry. Psychedelic-assisted psychotherapy is not only a new treatment paradigm in psychopharmacology, but it also requires a redefinition of psychotherapeutic processes and the contextualization of psychopharmacological interventions within a new treatment infrast...
Source: Pharmacopsychiatry - May 12, 2021 Category: Psychiatry Authors: Gr ünder, Gerhard Jungaberle, Henrik Tags: Review Source Type: research

5-HTTLPR-rs25531 and Antidepressant Treatment Outcomes in Korean Patients with Major Depression
Pharmacopsychiatry DOI: 10.1055/a-1478-4574 Introduction Despite the ethnic differences in 5-HTTLPR (S allele relates to better antidepressant response in Korean and Japanese people, while L allele with better response in Caucasians), it is unclear whether 5-HTTLPR and its high expression locus rs25531 are interactively associated with antidepressant treatment outcome. We investigated the individual and interaction effects of these polymorphisms on antidepressant treatment outcomes in the Korean population. Methods A total of 464 Korean subjects with major depressive disorder completed 6 weeks of antidepressant monotherapy...
Source: Pharmacopsychiatry - May 12, 2021 Category: Psychiatry Authors: Jang, Yoo Jin Lim, Shinn-Won Moon, Young Kyung Kim, Su Yeon Lee, Hong Kim, Seonwoo Kim, Doh Kwan Tags: Original Paper Source Type: research

Failing Memory in Nonaffective Psychosis and Prolactin Response to 12.5 µg i.v. TRH
Pharmacopsychiatry DOI: 10.1055/a-1481-9058The increase in plasma prolactin at 15 min following administration of 12.5 µg TRH i. v. (∆prol) was introduced in Pharmacopsychiatry as an inverse estimate of tuberoinfundibular dopamine (TIDA) activity 1. We used the unpublished data set in 20 participants with nonaffective psychosis from our 1991 study utilizing ∆prol 2 and here report new results with its association with memory. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstr...
Source: Pharmacopsychiatry - May 12, 2021 Category: Psychiatry Authors: Spoov, Johan Bredbacka, Per-Erik Tags: Letter to the Editor Source Type: research

Withanone Ameliorates Stress Symptoms in Caenorhabditis Elegans by Acting through Serotonin Receptors
Conclusion WN ameliorated depressive-associated stress symptoms by activating the serotonin system. WN may serve as potential candidate in developing new drugs to treat depression. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 6, 2021 Category: Psychiatry Authors: Na ß, Janine Efferth, Thomas Tags: Original Paper Source Type: research

Association between Adherence to SSRI Treatment and Mortality among Individuals with Metabolic Syndrome Components
This study aimed to examine the association between adherence to selective serotonin receptor inhibitors (SSRIs) and all-cause mortality among individuals with metabolic syndrome components (hypertension, obesity, and diabetes mellitus). Methods Data on 201 777 patients who were prescribed SSRIs during the years 2008–2011 were analyzed retrospectively. Adherence was measured using prescription purchase records. The moderating effect of SSRI and statin adherence on the association between metabolic syndrome load and mortality hazard risk (HR) during the study period were analyzed. The Cox-proportional hazard mo...
Source: Pharmacopsychiatry - April 14, 2021 Category: Psychiatry Authors: Avrahamy, Hamutal Shoval, Gal Hoshen, Moshe Balicer, Ran D. Kamhi-Nesher, Shiri Zalsman, Gil Weizman, Abraham Krivoy, Amir Tags: Original Paper Source Type: research

Are Persons Treated with Antidepressants and/or Antipsychotics Possibly Better Protected against Severe COVID 19?
Pharmacopsychiatry DOI: 10.1055/a-1408-8298 Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 17, 2021 Category: Psychiatry Authors: Bonnet, Udo Juckel, Georg Scherbaum, Norbert Schaefer, Martin Kis, Bernhard Cohen, Simon Kuhn, Jens Tags: Letter to the Editor Source Type: research

Impacts on Quality of Life with Escitalopram Monotherapy and Aripiprazole Augmentation in Patients with Major Depressive Disorder: A CAN-BIND Report
Pharmacopsychiatry DOI: 10.1055/a-1385-0263 Introduction Many individuals with major depressive disorder (MDD) do not respond to initial antidepressant monotherapy. Adjunctive aripiprazole is recommended for treatment non-response; however, the impacts on quality of life (QoL) for individuals who receive this second-line treatment strategy have not been described. Methods We evaluated secondary QoL outcomes in patients with MDD (n=179). After 8 weeks of escitalopram, non-responders (
Source: Pharmacopsychiatry - March 2, 2021 Category: Psychiatry Authors: Morton, Emma Bhat, Venkat Giacobbe, Peter Lou, Wendy Michalak, Erin E. Chakrabarty, Trisha Frey, Benicio N. Milev, Roumen V. M üller, Daniel J. Parikh, Sagar V. Rotzinger, Susan Kennedy, Sidney H. Lam, Raymond W. Tags: Original Paper Source Type: research

Metformin Attenuates the Metabolic Disturbance and Depression-like Behaviors Induced by Corticosterone and Mediates the Glucose Metabolism Pathway
Conclusion Our findings suggest that metformin can attenuate metabolism disturbances and depression-like behaviors induced by CORT mediating the glucose metabolism pathway. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 25, 2021 Category: Psychiatry Authors: Hao, Yong Tong, Yingpeng Guo, Yanhong Lang, Xiaoe Huang, Xinxin Xie, Xiaoxian Guan, Yangtai Li, Zezhi Tags: Original Paper Source Type: research

Sex-specific Association of Antipsychotic-induced Weight Gain and Treatment Response for Antipsychotic-Naive First Episode Schizophrenia Patients: A Prospective 8-week Longitudinal Study
Conclusions The relationship between weight gain and symptom reduction after 8 weeks of antipsychotic treatment exists only in male patients with ANFE SZ and not in female patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 24, 2021 Category: Psychiatry Authors: Shi, Hui Guan, Xiao Ni Liu, Dian Ying Zhu, Lin Wu, Zhi Wei Luo, Guo Zhi Wang, Jun Xiu, Mei Hong Zhang, Xiang Yang Tags: Original Paper Source Type: research

Opioid Mortality Following Implementation of Medical Cannabis Programs in the United States
This study evaluated differences following legal MC sales on US opioid-related overdose deaths, corrected for population, from 1999 to 2017 using an interrupted time series. Comparisons by MC status were also made for Medicaid expansion and the Centers for Disease Control death certificate reporting quality (0:
Source: Pharmacopsychiatry - February 23, 2021 Category: Psychiatry Authors: Kaufman, Daniel E. Nihal, Asawer M. Leppo, Janan D. Staples, Kelly M. McCall, Kenneth L. Piper, Brian J. Tags: Original Paper Source Type: research

Robustly High Hippocampal BDNF levels under Acute Stress in Mice Lacking the Full-length p75 Neurotrophin Receptor
Conclusions Our results provide evidence for a role of p75NTR signaling in the regulation of hippocampal BDNF levels, particularly under stress. Furthermore, p75NTR signaling modulates baseline but not stress-related Il6 gene expression in mice. Our findings implicate p75NTR signaling as a potential pathomechanism in BDNF-dependent modulation of risk for neuropsychiatric disorders. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 16, 2021 Category: Psychiatry Authors: Schott, Bj örn H. Kronenberg, Golo Schmidt, Ulrike D üsedau, Henning P. Ehrentraut, Stefanie Geisel, Olga von Bohlen und Halbach, Oliver Gass, Peter Dunay, Ildiko Rita Hellweg, Rainer Tags: Original Paper Source Type: research

Bipolar Disorder and Outcomes of Monotherapy with Lithium, Valproate, Quetiapine, Olanzapine, Venlafaxine, and Citalopram
Conclusions Our results underline the importance of lithium in the maintenance treatment of bipolar disorders. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 25, 2021 Category: Psychiatry Authors: Bohlken, Jens Riedel-Heller, Steffi Bauer, Michael Kostev, Karel Tags: Original Paper Source Type: research

Classical Psychedelics as Therapeutics in Psychiatry – Current Clinical Evidence and Potential Therapeutic Mechanisms in Substance Use and Mood Disorders
Pharmacopsychiatry DOI: 10.1055/a-1341-1907Classical psychedelics, primarily psilocybin and lysergic acid diethylamide (LSD), have been used and extensively studied in Western medicine as part of substance-assisted psychotherapy in the 1950s and 1960s. Modern clinical research is currently gaining momentum and provides new evidence for the safety and efficacy of classical psychedelics (primarily psilocybin, but also LSD and ayahuasca) in the treatment of different psychiatric conditions, including substance use and mood disorders.In this review article, we outline common pathological mechanisms of substance use disorders (...
Source: Pharmacopsychiatry - January 20, 2021 Category: Psychiatry Authors: Mertens, Lea J. Preller, Katrin H. Tags: Review Source Type: research

Pharmacological Treatment of Schizophrenia: Japanese Expert Consensus
Discussion These clinical recommendations represent the expert consensus on the use of a particular antipsychotic medication for a particular situation, filling a current gap in the literature. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 12, 2021 Category: Psychiatry Authors: Sakurai, Hitoshi Yasui-Furukori, Norio Suzuki, Takefumi Uchida, Hiroyuki Baba, Hajime Watanabe, Koichiro Inada, Ken Kikuchi, Yuka Sugawara Kikuchi, Toshiaki Katsuki, Asuka Kishida, Ikuko Kato, Masaki Tags: Original Paper Source Type: research

Effects of Discontinuation of Drugs Used for Augmentation Therapy on Treatment Outcomes in Depression: A Systematic Review and Meta-analysis
Pharmacopsychiatry DOI: 10.1055/a-1330-8587 Introduction There has been no consensus on whether and how long add-on drugs for augmentation therapy should be continued in the treatment of depression. Methods Double-blind randomized controlled trials that examined the effects of discontinuation of drugs used for augmentation on treatment outcomes in patients with depression were identified. Meta-analyses were performed to compare rates of study withdrawal due to any reason, study-defined relapse, and adverse events between patients who continued augmentation therapy and those who discontinued it. Results Seven studies were i...
Source: Pharmacopsychiatry - December 23, 2020 Category: Psychiatry Authors: Kato, Hideo Koizumi, Teruki Takeuchi, Hiroyoshi Tani, Hideaki Mimura, Masaru Uchida, Hiroyuki Tags: Original Paper Source Type: research

Frequencies of Genetic Polymorphisms of Clinically Relevant Gene-Drug Pairs in a German Psychiatric Inpatient Population
Discussion Our results suggest that our psychiatric inpatients were enriched with genotypes consistent with non-normal drug metabolism compared to reference populations. We therefore conclude that pharmacogenetic testing should be implemented in clinical practice to guide drug therapy. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - December 16, 2020 Category: Psychiatry Authors: Hahn, Martina M üller, Daniel J. Roll, Sibylle C. Tags: Original Paper Source Type: research

Treatment Goals for Patients with Schizophrenia — A Narrative Review of Physician and Patient Perspectives
Discussion Agreement between patients and physicians regarding valuation of treatment goals was high. However, physicians tended to put more emphasis on the classical “textbook” goals of symptom resolution and functioning, while patients stressed well-being and quality of life more. Results on treatment goals from patients are difficult to generalize, since recruiting representative patient samples is challenging and patient subgroups may have differing priorities. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  | &...
Source: Pharmacopsychiatry - December 8, 2020 Category: Psychiatry Authors: Gr ünder, Gerhard Bauknecht, Philipp Klingberg, Stefan Leopold, Karolina Paulzen, Michael Schell, Stefanie Stengler, Katarina Leucht, Stefan Tags: Review Source Type: research

Dose-Corrected Serum Concentrations and Metabolite to Parent Compound Ratios of Venlafaxine and Risperidone from Childhood to Old Age
Pharmacopsychiatry DOI: 10.1055/a-1302-8108 Objective Comparative pharmacokinetic data about the antidepressant venlafaxine (VEN) and the antipsychotic drug risperidone (RIS) over the lifespan and especially in children and adolescents is lacking. This is the first cross-sectional study that aimed to investigate differences in dose-corrected serum concentrations (CDs) and metabolite to parent compound ratios (MPRs) of VEN and RIS across the lifespan. Methods Patients treated with VEN and RIS at the University Hospital of Würzburg, Germany were included in the study. Serum level determinations were performed during cli...
Source: Pharmacopsychiatry - December 8, 2020 Category: Psychiatry Authors: Fekete, Stefanie Scherf-Clavel, Maike Gerlach, Manfred Romanos, Marcel Kittel-Schneider, Sarah Unterecker, Stefan Egberts, Karin Tags: Original Paper Source Type: research

The History of Psychedelics in Psychiatry
Pharmacopsychiatry DOI: 10.1055/a-1310-3990Initial interest in the value of psychedelic drugs (“psychotomimetics”) in psychiatry began in the early 20th century, with explorations of the possibility that mescaline or peyote could produce psychosis-like effects. Over time, interest was focused on whether the effects of psychedelics could inform as to the underlying basis for psychiatric disorders. As research continued, and especially after the discovery of LSD in 1943, increasing interest in a role for psychedelics as adjuncts to psychotherapy began to evolve and became the major focus of work with psychedelics...
Source: Pharmacopsychiatry - December 7, 2020 Category: Psychiatry Authors: Nichols, David E. Walter, Hannes Tags: Review Source Type: research

Psychedelics and Psychotherapy
Pharmacopsychiatry DOI: 10.1055/a-1312-7297Psychedelics have shown great promise in modern clinical trials for treating various psychiatric conditions. As a transdiagnostic treatment that exerts its effects through subjective experiences that leave enduring effects, it is akin to psychotherapy. To date, there has been insufficient discussion of how psychedelic therapy is similar to and different from conventional psychotherapy. In this article, we review the shared features of effective conventional psychotherapies and situate therapeutic psychedelic effects within those. We then discuss how psychedelic drug effects might ...
Source: Pharmacopsychiatry - December 7, 2020 Category: Psychiatry Authors: Nayak, Sandeep Johnson, Matthew W. Tags: Review Source Type: research

Neurotrophic Properties of Silexan, an Essential Oil from the Flowers of Lavender-Preclinical Evidence for Antidepressant-Like Properties
Conclusion Taken together, Silexan demonstrates antidepressant-like effects in cellular as well as animal models for antidepressant activity. Therefore, our data provides preclinical evidence for the clinical antidepressant effects of Silexan in patients with mixed depression and anxiety. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 30, 2020 Category: Psychiatry Authors: Friedland, Kristina Silani, Giacomo Schuwald, Anita Stockburger, Carola Koch, Egon N öldner, Michael M üller, Walter E. Tags: Original Paper Source Type: research

Novel Long-Acting Buprenorphine Medications for Opioid Dependence: Current Update
Pharmacopsychiatry DOI: 10.1055/a-1298-4508Opioid maintenance treatment with oral methadone or sublingual buprenorphine is the first-line treatment in opioid dependence. Three novel long-acting buprenorphine formulations have been approved or will be available soon: for subcutaneous weekly and monthly application, the depot formulations CAM 2038 (Buvidal®), the monthly depot formulation RBP-6000 (Sublocade™), and a 6-month buprenorphine implant (Probuphine™). Clinical data available so far on the efficacy of these 3 medications are given, and possible clinical implications are discussed. [...] Georg Thieme ...
Source: Pharmacopsychiatry - November 19, 2020 Category: Psychiatry Authors: Soyka, Michael Tags: Review Source Type: research

Association between Adherence with an Atypical Antipsychotic and with Other Psychiatric Drugs in Patients with Bipolar Disorder
This study investigated whether adherence to an atypical antipsychotic was related to adherence to other prescribed psychiatric drugs using self-reported data from patients with bipolar disorder. Methods Daily self-reported medication data were available from 123 patients with a diagnosis of bipolar disorder receiving treatment as usual who took at least 1 atypical antipsychotic over a 12-week period. Patients took a mean of 4.0±1.7 psychiatric drugs including the antipsychotic. The adherence rate for the atypical antipsychotic was compared to that for other psychiatric d...
Source: Pharmacopsychiatry - November 17, 2020 Category: Psychiatry Authors: Bauer, Michael Glenn, Tasha Alda, Martin Grof, Paul Monteith, Scott Rasgon, Natalie Severus, Emanuel Whybrow, Peter C. Tags: Original Paper Source Type: research

Alterations in BDNF Protein Concentrations in the Hippocampus do not Explain the Pro-Neurogenic Effect of Citalopram on Adult Neurogenesis
In this study, we used Tph2 −/− mice lacking brain serotonin to dissect the interplay between BDNF and the serotonin system in mediating the effects of antidepressant pharmacotherapy on adult neurogenesis in the hippocampus. Methods Besides citalopram (CIT), we tested tianeptine (TIA), an antidepressant whose mechanism of action is not well understood. Specifically, we examined cell survival and endogenous concentrations of BDNF following daily injection of the drugs. Results Twenty-one days of CIT, but not of TIA, led to a significant increase in the survival of newly generated cells in the dentate gyrus of ...
Source: Pharmacopsychiatry - November 16, 2020 Category: Psychiatry Authors: Petermann, Markus Kronenberg, Golo Mosienko, Valentina Bader, Michael Alenina, Natalia Hellweg, Rainer Klempin, Friederike Tags: Original Paper Source Type: research

Review and Consensus on Pharmacogenomic Testing in Psychiatry
Pharmacopsychiatry DOI: 10.1055/a-1288-1061The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest, in part due to divergent perceptions of the quality and completeness of the evidence base and diverse perspectives on the clinical utility of PGx testing among psychiatrists and other healthcare providers. Recognizing the current lack of consensus within the field, the International Society of Psychiatric Genetics assembled a group of experts to conduct a narrative synthesis of the PGx literature, prescribing guidelines, and product labels related to psychotropic me...
Source: Pharmacopsychiatry - November 4, 2020 Category: Psychiatry Authors: Bousman, Chad A. Bengesser, Susanne A. Aitchison, Katherine J. Amare, Azmeraw T. Aschauer, Harald Baune, Bernhard T. Asl, Bahareh Behroozi Bishop, Jeffrey R. Burmeister, Margit Chaumette, Boris Chen, Li-Shiun Cordner, Zachary A. Deckert, J ürgen Degenhar Tags: Review Source Type: research

Review and Consensus on Pharmacogenomic Testing in Psychiatry
Pharmacopsychiatry DOI: 10.1055/a-1288-1061The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest, in part due to divergent perceptions of the quality and completeness of the evidence base and diverse perspectives on the clinical utility of PGx testing among psychiatrists and other healthcare providers. Recognizing the current lack of consensus within the field, the International Society of Psychiatric Genetics assembled a group of experts to conduct a narrative synthesis of the PGx literature, prescribing guidelines, and product labels related to psychotropic medications as well as the key consid...
Source: Pharmacopsychiatry - November 4, 2020 Category: Psychiatry Authors: Bousman, Chad A. Bengesser, Susanne A. Aitchison, Katherine J. Amare, Azmeraw T. Aschauer, Harald Baune, Bernhard T. Asl, Bahareh Behroozi Bishop, Jeffrey R. Burmeister, Margit Chaumette, Boris Chen, Li-Shiun Cordner, Zachary A. Deckert, J ürgen Degenhar Tags: Review Source Type: research

On a Very Basic Behavior in Science: Importance and Issues with Quotations
Pharmacopsychiatry DOI: 10.1055/a-1246-3122This journal, founded in 1968, not only has a publication history of more than 5 decades but also stands for a distinct scientific focus in psychiatric pharmacology or psychopharmacology: the research on medication treatments for mental disorders. At some point, it is worth taking a broader look at what we are doing in psychiatry or in medicine in general. That is why, in this issue, we are publishing a study by Christopher Baethge 1 that typically may not fit into the scope of Pharmacopsychiatry. As a psychiatrist and an editor, Baethge carried ...
Source: Pharmacopsychiatry - October 19, 2020 Category: Psychiatry Authors: Bauer, Michael Tags: Editorial Source Type: research

Subtypes of Clinical High Risk for Psychosis that Predict Antipsychotic Effectiveness in Long-Term Remission
Discussion These subtypes may be of clinical value in AP treatment decision-making in the CHR population. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - October 12, 2020 Category: Psychiatry Authors: Zhang, TianHong Wang, JunJie Xu, LiHua Wei, YanYan Tang, XiaoChen Hu, YeGang Cui, HuiRu Tang, YingYing Hui, Li Li, ChunBo Wang, JiJun Tags: Original Paper Source Type: research

Safety Profile of Methylphenidate Under Long-Term Treatment in Adult ADHD Patients – Results of the COMPAS Study
Conclusion In this so far longest-running clinical trial, methylphenidate treatment was safe and well-tolerated. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - October 4, 2020 Category: Psychiatry Authors: Kis, Bernhard L ücke, Caroline Abdel-Hamid, Mona He ßmann, Philipp Graf, Erika Berger, Mathias Matthies, Swantje Borel, Patricia Sobanski, Esther Alm, Barbara R ösler, Michael Retz, Wolfgang Jacob, Christian Colla, Michael Huss, Michael Jans, Thomas va Tags: Original Paper Source Type: research

Lack of Smoking Effects on Pharmacokinetics of Oral Paliperidone-analysis of a Naturalistic Therapeutic Drug Monitoring Sample
Discussion Paliperidone is not affected by smoking, and paliperidone dose-adjustments in smokers may not be necessary. This may be seen as an essential difference to risperidone, whose cytochrome-mediated metabolism might be affected by smoking. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 5, 2020 Category: Psychiatry Authors: Schoretsanitis, Georgios Haen, Ekkehard Conca, Andreas Piacentino, Daria Ridders, Florian Hiemke, Christoph Gr ünder, Gerhard Paulzen, Michael Tags: Original Paper Source Type: research

Effects of Smoking Status on Remission and Metabolic and Cognitive Outcomes in Schizophrenia Patients Treated with Clozapine
Conclusions Smoking behavior among clozapine-treated schizophrenia patients might delineate a cohort with an earlier onset of the disease. Nevertheless, most findings comparing disease-specific and clinical outcomes among smokers and nonsmokers were negative. Further research is needed to identify strategies to overcome insufficient remission rates in this patient group. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 4, 2020 Category: Psychiatry Authors: Wagner, Elias Oviedo-Salcedo, Tatiana Pelzer, Nicola Strube, Wolfgang Maurus, Isabel Gutwinski, Stefan Schreiter, Stefanie Kleymann, Phillip Morgenroth, Carla-Lou Okhuijsen-Pfeifer, Cynthia Luykx, Jurjen J. Falkai, Peter Schneider-Axmann, Thomas Hasan, Al Tags: Original Paper Source Type: research

„Peter Müller Preis für Forschung im Bereich Schizophrenie“ in Höhe von 5.000€
Pharmacopsychiatry 2020; 53: 194-194 DOI: 10.1055/a-1170-9204Die Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) e.V. ist eine deutschsprachige Fachgesellschaft für neuropsychopharmakologische Forschung und ihre Anwendung in der Therapie von neuropsychiatrisch erkrankten Menschen. Eines der wichtigsten Ziele der Arbeitsgemeinschaft stellt die Mitgestaltung des Fortschritts in der Psychopharmakotherapie dar. Daher fördert die AGNP e.V. Forschungsarbeiten im Bereich der Psychopharmakologie und schreibt dieses Jahr erstmalig den [...] © Georg Th...
Source: Pharmacopsychiatry - July 26, 2020 Category: Psychiatry Tags: Ausschreibung Peter M üller Preis Source Type: research

„AGNP-Preis für Forschung in der Psychopharmakologie“ in Höhe von 5.000 €
Pharmacopsychiatry 2020; 53: 193-193 DOI: 10.1055/a-1170-9235Wohl kaum eine andere Arzneimittelgruppe hat durch ihre Einführung so immense therapeutische Möglichkeiten eröffnet wie die Psychopharmaka. In den über 60 Jahren seit ihrer Entdeckung haben sie vielen psychisch Kranken entscheidend geholfen. Heute sind sie aus der Therapie psychischer Erkrankungen nicht mehr wegzudenken. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 26, 2020 Category: Psychiatry Tags: Ausschreibung AGNP-Forschungspreis Source Type: research

Pharmacogenetics in Psychiatry
Pharmacopsychiatry 2020; 53: 153-154 DOI: 10.1055/a-1212-1101This Special Issue on Pharmacogenetics in Psychiatry consists of five selected articles which encompass the first concepts of pharmacogenetics, to implementation strategies applyng pharmacogenetic testing into psychiatric clinical practice. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - July 26, 2020 Category: Psychiatry Authors: M üller, Daniel J. Tags: Editorial Source Type: research

Patients ’ Perspectives on Psychiatric Pharmacogenetic Testing
This study sought to assess genotyped patients’ perspectives and experiences with psychiatric PGx testing. Methods Individual semi-structured interviews were conducted among patients with depression who had undergone psychiatric PGx testing. The audio-recorded interviews were transcribed and analyzed inductively and deductively for salient themes. Results Twenty patients (100% Caucasian, 60% female, mean age 39±18 years) were interviewed. The majority of the PGx tests were provider-initiated for patients who failed multiple pharmacotherapies (50%) and...
Source: Pharmacopsychiatry - June 23, 2020 Category: Psychiatry Authors: Liko, Ina Lai, Erika Griffin, Rachel J. Aquilante, Christina L. Lee, Yee Ming Tags: Original Paper Source Type: research

Cross-Cultural Validity of Psychological Distress Measurement During the Coronavirus Pandemic
Pharmacopsychiatry DOI: 10.1055/a-1190-5029 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 23, 2020 Category: Psychiatry Authors: Liu, Shuyan Heinz, Andreas Tags: Letter to the Editor Source Type: research

Importance, Errors, and Patterns of Quotations to Psychiatric Original Articles
Discussion Quotations are important for the message of the quoting paper. Therefore, quotation errors may be detrimental to scientific reasoning and may undermine public trust in medical science. The present investigation is a case study, and its results are exploratory. While it is plausible that the findings translate into other environments, independent replication is needed. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 1, 2020 Category: Psychiatry Authors: Baethge, Christopher Tags: Original Paper Source Type: research

Erratum
Pharmacopsychiatry 2020; 53: 140- DOI: 10.1055/a-1175-3320 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 27, 2020 Category: Psychiatry Tags: Erratum Source Type: research