Patients ’ Perspectives on Psychiatric Pharmacogenetic Testing
This study sought to assess genotyped patients’ perspectives and experiences with psychiatric PGx testing. Methods Individual semi-structured interviews were conducted among patients with depression who had undergone psychiatric PGx testing. The audio-recorded interviews were transcribed and analyzed inductively and deductively for salient themes. Results Twenty patients (100% Caucasian, 60% female, mean age 39±18 years) were interviewed. The majority of the PGx tests were provider-initiated for patients who failed multiple pharmacotherapies (50%) and...
Source: Pharmacopsychiatry - June 24, 2020 Category: Psychiatry Authors: Liko, Ina Lai, Erika Griffin, Rachel J. Aquilante, Christina L. Lee, Yee Ming Tags: Original Paper Source Type: research

Cross-Cultural Validity of Psychological Distress Measurement During the Coronavirus Pandemic
Pharmacopsychiatry DOI: 10.1055/a-1190-5029 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 24, 2020 Category: Psychiatry Authors: Liu, Shuyan Heinz, Andreas Tags: Letter to the Editor Source Type: research

Importance, Errors, and Patterns of Quotations to Psychiatric Original Articles
Discussion Quotations are important for the message of the quoting paper. Therefore, quotation errors may be detrimental to scientific reasoning and may undermine public trust in medical science. The present investigation is a case study, and its results are exploratory. While it is plausible that the findings translate into other environments, independent replication is needed. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 2, 2020 Category: Psychiatry Authors: Baethge, Christopher Tags: Original Paper Source Type: research

Erratum
Pharmacopsychiatry 2020; 53: 140- DOI: 10.1055/a-1175-3320 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 28, 2020 Category: Psychiatry Tags: Erratum Source Type: research

Case of Severe Acute-on-Chronic Lithium Intoxication with 8.6 mmol/l and Prompt Hemodialysis
Pharmacopsychiatry DOI: 10.1055/a-1167-3267Lithium has been the gold standard in the long-term treatment of bipolar disorder for more than 40 years 1. Due to a narrow therapeutic index lithium intoxication still is a common but potentially avoidable clinical problem 2. The possibility of SILENT-syndrome (syndrome of irreversible lithium-effectuated neurotoxicity) illustrates that prevention and optimal treatment of lithium intoxication is vitally important 3. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract ...
Source: Pharmacopsychiatry - May 11, 2020 Category: Psychiatry Authors: Haussmann, Robert Donix, Markus Bauer, Michael von Bonin, Simone Lewitzka, Ute Tags: Letter to the Editor Source Type: research

Potential Drug interactions with Drugs used for Bipolar Disorder: A Comparison of 6 Drug Interaction Database Programs
Conclusion There is poor agreement among drug interaction database programs for the category of potential DDI involving psychiatric drugs. Drug interaction database programs provide valuable information, but the lack of consistency should be recognized as a limitation. When assistance is needed, physicians should check more than 1 drug interaction database program. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - April 30, 2020 Category: Psychiatry Authors: Monteith, Scott Glenn, Tasha Gitlin, Michael Bauer, Michael Tags: Original Paper Source Type: research

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Pharmacopsychiatry 2020; 03 Article in Thieme eJournals: Table of contents  |  Congress (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - April 30, 2020 Category: Psychiatry Source Type: research

Safety and Tolerability of the Anxiolytic and Nootropic Drug Phenibut: A Systematic Review of Clinical Trials and Case Reports
Pharmacopsychiatry DOI: 10.1055/a-1151-5017Phenibut is a nootropic drug that exerts anxiolytic and antinociceptive effects by acting on the GABAB receptor and the α2-δ subunit of voltage-dependent calcium channels. An increased number of reports of dependence to and intoxication by phenibut purchased online on the one hand and the wide prescription of phenibut in Eastern Europe for more than half a century on the other hand have resulted in a number of controversies regarding its use. In this review, we have summarized currently available information from case reports of phenibut dependence and intoxication and...
Source: Pharmacopsychiatry - April 27, 2020 Category: Psychiatry Authors: Kupats, Einars Vrublevska, Jelena Zvejniece, Baiba Vavers, Edijs Stelfa, Gundega Zvejniece, Liga Dambrova, Maija Tags: Review Source Type: research

Synchronization of Fibroblasts Ex Vivo in Psychopharmacology
Pharmacopsychiatry DOI: 10.1055/a-1151-4947The central oscillator for the inner clock is the suprachiasmatic nuclei of the hypothalamus. Furthermore, many peripheral oscillators are present in tissues such as skin. Human derived fibroblasts provide an advantageous model to study circadian rhythmicity as well as the influence of pharmacological drugs on circadian gene expression. Importantly, the synchronization of the circadian system of fibroblasts can be done by different methods. The review presents an overview of the current knowledge of different synchronization methods mostly used in mice or rat fibroblasts. Furtherm...
Source: Pharmacopsychiatry - April 27, 2020 Category: Psychiatry Authors: Faltraco, Frank Uzoni, Adriana Shevchuk, Liliia Thome, Johannes Palm, Denise Tags: Review Source Type: research

Drug-Drug Interactions Between Lithium and Cardiovascular as Well as Anti-Inflammatory Drugs
Discussion Routine clinical practice needs to focus on drugs affecting renal blood flow and function, especially on NSAIDs as over-the-counter medication that may lead to an increase in lithium serum concentration. To prevent intoxications, clinicians should carefully monitor the comedications, and they should inform patients about possible intoxications due to NSAIDs. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - April 27, 2020 Category: Psychiatry Authors: Scherf-Clavel, Maike Treiber, Susanne Deckert, J ürgen Unterecker, Stefan Hommers, Leif Tags: Original Paper Source Type: research

Paliperidone LAI and Aripiprazole LAI Plasma Level Monitoring in the Prophylaxis of Bipolar Disorder Type I with Manic Predominance
The objective of this study was the evaluation of utility of plasma level monitoring in the clinical stabilizing efficacy and tolerability of paliperidone palmitate (PP) vs. aripiprazole monohydrate (AM) in bipolar disorder I (BD I) with manic predominance. Methods Fifty-six outpatients of both sexes, age ranging from 18 to 65 years, affected by BD I with manic predominance, orally treated and stabilized after acute episode for at least 2 weeks with paliperidone or aripiprazole (n=31, paliperidone; n=25, aripiprazole) underwent a prospective observational study of switching to the corresponding long-acting injection (LAI) ...
Source: Pharmacopsychiatry - March 10, 2020 Category: Psychiatry Authors: Mauri, Massimo Carlo Reggiori, Alessandra Minutillo, Alessandro Franco, Gemma Pace, Chiara Di Paletta, Silvia Cattaneo, Dario Tags: Original Paper Source Type: research

Prevalence of Psychotropic Drugs in Cases of Severe Adverse Drug Reactions Leading to Unplanned Emergency Visits in General Hospitals
Pharmacopsychiatry DOI: 10.1055/a-1110-1010 Introduction The prevalence of psychotropic drug use in our society is increasing especially in older adults, thereby provoking severe adverse drug reactions (ADR). To identify specific patient risk profiles associated with psychotropic drug use in the situation of polymedication. Methods Cases of ADRs in general emergency departments (ED) collected within the multi-center prospective observational study (ADRED) were analyzed (n=2215). We compared cases with use of psychotropic drugs and without concerning their clinical presentatio...
Source: Pharmacopsychiatry - February 27, 2020 Category: Psychiatry Authors: Stingl, Julia C. Just, Katja S. Schurig, Marlen B öhme, Miriam Steffens, Michael Schwab, Matthias Seufferlein, Thomas Dormann, Harald Tags: Original Paper Source Type: research

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Pharmacopsychiatry 2020; 02 Article in Thieme eJournals: Table of contents  |  Congress (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 24, 2020 Category: Psychiatry Source Type: research

Pharmacogenetic Testing in Depressed Patients and Interdisciplinary Exchange between a Pharmacist and Psychiatrists Results in Reduced Hospitalization Times
Pharmacopsychiatry DOI: 10.1055/a-1096-1171 Introduction Pharmacogenetics (PGx) is a well-researched tool to improve pharmacotherapy. So far, it has not been implemented into daily practice in Germany. In psychopharmacology, substantial benefit can be expected by using PGx due to the excessive CYP metabolism of the psychotropic drugs as well as already discovered target polymorphisms (e. g., serotonin receptor). Methods An evaluation of a naturalistic pharmacist-led pilot implementation of PGx testing in a psychiatric hospital in patients undergoing inpatient tre...
Source: Pharmacopsychiatry - February 11, 2020 Category: Psychiatry Authors: B ättig, Victor A. D. Roll, Sibylle C. Hahn, Martina Tags: Original Paper Source Type: research

Blonanserin patch vs. Other Antipsychotics for Acute Schizophrenia: A Systematic Review of Double-blind, Randomized, Placebo-controlled, Phase 3 Trials in Japan
Discussion BLO-P40+80 may have a good efficacy/safety/tolerability profile for the treatment of patients with acute schizophrenia. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 30, 2020 Category: Psychiatry Authors: Kishi, Taro Yoshimura, Reiji Matsuda, Yuki Sakuma, Kenji Iwata, Nakao Tags: Original Paper Source Type: research

Efficacy and Safety of Psychostimulants for Alzheimer ’s Disease: A Systematic Review and Meta-Analysis
Discussion Methylphenidate would be effective in treating apathy and cognitive impairment in AD patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 30, 2020 Category: Psychiatry Authors: Kishi, Taro Sakuma, Kenji Iwata, Nakao Tags: Original Paper Source Type: research

Therapeutic Drug Monitoring in Buprenorphine/Naloxone Treatment for Opioid Use Disorder: Clinical Feasibility and Optimizing Assay Precision
Conclusions TDM for BUP maintenance treatment of OUD is feasible, and simple adjustment of the assay conditions enhances BUP recovery. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 30, 2020 Category: Psychiatry Authors: Elarabi, Hesham Farouk Hasan, Nael Marsden, John Radwan, Doaa Adem, Abdu Almamari, Samya Elrasheed, Abuelgasim Tags: Original Paper Source Type: research

Drug-Induced Liver Injury (DILI) in Patients with Depression Treated with Antidepressants: A Retrospective Multicenter Study
Discussion During patient characterization it becomes clear that a sensitization for relevant risk constellations causing liver injury in MDD patients is relevant to prevent further serious adverse events. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 20, 2020 Category: Psychiatry Authors: Ueberberg, Bianca Frommberger, Ulrich Messer, Thomas Zwanzger, Peter Kuhn, Jens Anghelescu, Ion Ackermann, Katharina Assion, Hans-J örg Tags: Original Paper Source Type: research

Treatment of the Neuroleptic Malignant Syndrome in International Therapy Guidelines: a Comparative Analysis
Discussion One-third of the selected guidelines do not report any NMS therapy recommendations. Most guidelines mentioning the NMS do not provide therapy recommendations that include all relevant treatment options. The results show a very high heterogeneity, and the recommendations and statements are of low-evidence levels. The lack of knowledge about the NMS and its treatment may delay the onset of therapy, impair the quality of treatment, and lead to a worse outcome or death. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents&nb...
Source: Pharmacopsychiatry - December 9, 2019 Category: Psychiatry Authors: Sch önfeldt-Lecuona, Carlos Kuhlwilm, Lilli Cronemeyer, Maximilian Neu, Peter Connemann, Bernhard J. Gahr, Maximilian Sartorius, Alexander M ühlbauer, Viktoria Tags: Review Source Type: research

Circadian Clocks in the Regulation of Neurotransmitter Systems
Pharmacopsychiatry DOI: 10.1055/a-1027-7055To anticipate and adapt to daily recurring events defined by the earth’s rotation such as light-dark and temperature cycles, most species have developed internal, so-called circadian clocks. These clocks are involved in the regulation of behaviors such as the sleep-wake cycle and the secretion of hormones and neurotransmitters. Disruptions of the circadian system affect cognitive functions and are associated with various diseases that are characterized by altered neurotransmitter signaling. In this review, we summarize the current knowledge about the interplay of the circadi...
Source: Pharmacopsychiatry - October 30, 2019 Category: Psychiatry Authors: Kiehn, Jana-Thabea Faltraco, Frank Palm, Denise Thome, Johannes Oster, Henrik Tags: Review Source Type: research

The Effects of Co-prescription of Pantoprazole on the Clozapine Metabolism
Pharmacopsychiatry DOI: 10.1055/a-1021-8827 Background Polypharmacy including somatic medications such as proton pump inhibitors is a common phenomenon in psychiatric care. The aim of this study was to evaluate the pantoprazole effects on clozapine metabolism. Methods A large therapeutic drug-monitoring database containing plasma concentrations of CLZ was analyzed. The results were stratified into four groups: a non-smoking (n=250) and a smoking group (n=326), and two groups co-medicated with pantoprazole: non-smokers (n=26) and smokers (n=29). The analysis was based on the non-parametrical Mann-Whitney U test (M-W-U) with...
Source: Pharmacopsychiatry - October 15, 2019 Category: Psychiatry Authors: Kuzin, Maxim Schoretsanitis, Georgios Haen, Ekkehard Dammann, Gerhard Hiemke, Christoph Gr ünder, Gerhard Paulzen, Michael Tags: Original Paper Source Type: research

Supplementary Medicines in Psychiatry
Pharmacopsychiatry DOI: 10.1055/a-0998-8161 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - October 9, 2019 Category: Psychiatry Authors: Juckel, Georg Tags: Editorial Source Type: research

Comparison of International Therapy Guidelines with Regard to the Treatment of Malignant Catatonia
Conclusion Many international guidelines do not mention MC. It is not possible to derive a clear algorithm for the treatment of MC from most current guidelines. A thorough update of most guidelines appears to be necessary. Lack of awareness and knowledge of MC among physicians and medical professionals might lead to inadequate or delayed care, worsened outcome, or death. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 26, 2019 Category: Psychiatry Authors: Sch önfeldt-Lecuona, Carlos Cronemeyer, Maximilian Hiesener, Lilli Connemann, Bernhard J. Gahr, Maximilian Sartorius, Alexander M ühlbauer, Viktoria Tags: Review Source Type: research

From the Origins of Pharmacogenetics to First Applications in Psychiatry
This article will highlight the conceptual framework for pharmacogenetics advanced by pioneer scientists Arno Motulsky and Friedrich Vogel (both human geneticists), as well as Werner Kalow (clinical pharmacologist), leading up to the creation of modern pharmacogenetics. Finally, the practical implications and first steps toward implementation for current psychiatric treatment are reviewed followed by an outlook on future studies. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 23, 2019 Category: Psychiatry Authors: M üller, Daniel J. Rizhanovsky, Zoe Tags: Review Source Type: research

Clinical Utilization of Pharmacogenetics in Psychiatry – Perspectives of Pharmacists, Genetic Counselors, Implementation Science, Clinicians, and Industry
Discussion PGx testing can assist in medication selection and improve patient outcomes; however, more data are needed to understand when and how to incorporate PGx testing into psychiatric practice. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 11, 2019 Category: Psychiatry Authors: Brown, Lisa Eum, Seenae Haga, Susanne B. Strawn, Jeffrey R. Zierhut, Heather Tags: Review Source Type: research

Retrospective Analysis of Risk Factors for Periodic Limb Movements in a Large Cohort of Insomnia and Chronic Fatigue Patients
Discussion This retrospective study adds supportive evidence to the association of drug classes with PLMS and PLMD. These findings may impact on clinical management of patients with a combined anxiety or mood disorder in need for these drug classes on the one hand and a significant sleep architecture disturbance through PLMS, potentially contributing to daytime symptoms, on the other hand. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 27, 2019 Category: Psychiatry Authors: Tobback, Els Desmet, Olivier Hanoulle, Ignace Delesie, Liesbeth Pevernagie, Dirk Vogelaers, Dirk Mariman, An Tags: Original Paper Source Type: research

Ketamine in the Treatment of Depressive Episodes
Pharmacopsychiatry DOI: 10.1055/a-0991-0582The treatment of depressive episodes remains complicated by the long latency of antidepressant efficacy, insufficient response, and high risk of suicide. Ketamine and esketamine have been proposed as fast-acting substances able to overcome these impediments.Since the first randomized controlled trial in the year 2000, numerous studies have explored the antidepressant efficacy of ketamine and esketamine. Clear evidence has emerged that a single infusion exerts a significant antidepressant and antisuicidal effect in both unipolar and bipolar depression. A few studies suggest that an...
Source: Pharmacopsychiatry - August 21, 2019 Category: Psychiatry Authors: Ritter, Philipp Findeis, Hannelore Bauer, Michael Tags: Review Source Type: research

Psychiatry is Broadening the Biological Paradigm at Last – A Commentary on Hoffmann et al. “Dietary Supplements in Psychiatric Treatment – A Narrative Review”
Pharmacopsychiatry DOI: 10.1055/a-0987-0366 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 21, 2019 Category: Psychiatry Authors: Walach, Harald Tags: Commentary Source Type: research

Acute and Long-term Memantine Add-on Treatment to Risperidone Improves Cognitive Dysfunction in Patients with Acute and Chronic Schizophrenia
Discussions Our study gives further evidence that memantine add-on treatment to risperidone may have neuroprotective effects and improve cognitive function in patients with schizophrenia. ClinicalTrials.gov Number: NCT00148590 and NCT00148616. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 7, 2019 Category: Psychiatry Authors: Schaefer, Martin Sarkar, Susanne Theophil, Ines Leopold, Karolina Heinz, Andreas Gallinat, J ürgen Tags: Original Paper Source Type: research

Hippocampal Dysfunction in Schizophrenia and Aberrant Hippocampal Synaptic Plasticity in Rodent Model Psychosis: a Selective Review
Pharmacopsychiatry DOI: 10.1055/a-0960-9846Schizophrenia is a complex, heterogeneous psychiatric disorder that affects about 1% of the global population. Hippocampal dysfunction has been linked to both cognitive deficits and positive symptoms in schizophrenia. Here, we briefly review current findings on disrupted hippocampal processing from a clinical perspective before concentrating on preclinical studies of aberrant hippocampal synaptic plasticity using the N-methyl-D-aspartate receptor hypofunction model of psychosis and related findings from genetic models. Taken together, the results put the case for maladaptive hippo...
Source: Pharmacopsychiatry - August 1, 2019 Category: Psychiatry Authors: Bartsch, Julia C. Schott, Bj örn H. Behr, Joachim Tags: Review Source Type: research

The Role of Dietary Supplements in Depression and Anxiety – A Narrative Review
Discussion This review summarizes the current knowledge about supplements when used for some psychiatric conditions, but the data does not provide compelling evidence in any direction. There are only indications that there is an influence of supplements on psychiatric diseases. In support of this, there is further need for high-quality studies in this field. Reviews on other diagnoses, such as schizophrenia and dementia, will be part of further work. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full tex...
Source: Pharmacopsychiatry - July 8, 2019 Category: Psychiatry Authors: Hoffmann, Knut Emons, Barbara Brunnhuber, Stefan Karaca, Sedya Juckel, Georg Tags: Review Source Type: research

Adjunctive Reboxetine for Schizophrenia: Meta-analysis of Randomized Double-blind, Placebo-controlled Trials
Conclusion Adjunctive reboxetine could be useful for attenuating antipsychotic-induced weight gain, but it was not effective in treating psychopathology including negative symptoms in schizophrenia. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 17, 2019 Category: Psychiatry Authors: Zheng, Wei Li, Xian-Bin Shi, Zhan-Ming Yang, Xin-Hu Cai, Dong-Bin Ng, Chee H. Ungvari, Gabor S. Liu, Wei-Jian Wu, Yu-Jie Wang, Yuan-Yuan Ning, Yu-Ping Xiang, Yu-Tao Tags: Original Paper Source Type: research

Roadmap for Routine Pharmacogenetic Testing in a Psychiatric University Hospital
This article describes a pilot study design aimed to combine clinical variables such as therapeutic drug monitoring, inflammatory and stress markers with static and variable genetic information of depressed patients to develop an algorithm that predicts treatment response, and tolerability using machine learning algorithms. Psychometric evaluation covers the Hamilton Depression Rating Scale, the Childhood Trauma Questionnaire, and adverse drug reactions. An in-depth (epi-)genetic assessment combines genome-wide gene association data with DNA methylation patterns of genes coding CYP enzymes along with a pharmacogenetic batt...
Source: Pharmacopsychiatry - June 11, 2019 Category: Psychiatry Authors: Menke, Andreas Weber, Heike Deckert, J ürgen Tags: Original Paper Source Type: research

8-Hydroxylation and Glucuronidation of Mirtazapine in Japanese Psychiatric Patients: Significance of the Glucuronidation Pathway of 8-Hydroxy-Mirtazapine
Discussion  The plasma concentration of 8-OH-MIR was as low as 1.42 nmol/L, whereas 8-OH-MIR-G had an approximate 59.50 times higher concentration than 8-OH-MIR, suggesting a significant role for hydroxylation of MIR and its glucuronidation in the Japanese population. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - June 3, 2019 Category: Psychiatry Authors: Shinozaki, Masataka Pierce, Jason Hayashi, Yuki Watanabe, Takashi Sasaki, Taro Komahashi-Sasaki, Hazuki Akiyama, Kazufumi Kato, Kazuko Inoue, Yoshimasa Tsuchimine, Shoko Yasui-Furukori, Norio Ozeki, Yuji Shimoda, Kazutaka Tags: Original Paper Source Type: research

Very Low Frequency of Drug Therapy of Alcohol Dependence in Germany – Analysis of Data of A Statutory Health Insurance
Pharmacopsychiatry DOI: 10.1055/a-0896-2757Acamprosate and naltrexone are medications of proven efficacy in the treatment of alcohol dependence. In order to investigate the prescription of these drugs in outpatient routine treatment in Germany (frequency of prescription, duration, medical specialty of prescribing physician), data of a large statutory health insurance were analyzed. Persons were included who were discharged from inpatient treatment with an alcohol-related disorder among their diagnoses during a one year observation period and with no diagnosed additional substance-related disorder (apart from nicotine- and ...
Source: Pharmacopsychiatry - May 27, 2019 Category: Psychiatry Authors: Scherbaum, Norbert Holzbach, R üdiger Stammen, Gunnar Kirchof, Ute Bonnet, Udo Tags: Letter to the Editor Source Type: research

Can Kampo and Dietary Supplement Address Unmet Need? – A Commentary on Tatsumi et al. and Hoffmann et al.
Pharmacopsychiatry DOI: 10.1055/a-0902-5145 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - May 23, 2019 Category: Psychiatry Authors: Tsuboi, Takashi Tags: Commentary Source Type: research

Pathological Concentration of C-reactive Protein is Correlated to Increased Concentrations of Quetiapine, But Not of Risperidone, Olanzapine and Aripiprazole in a Naturalistic Setting
Pharmacopsychiatry DOI: 10.1055/a-0869-8053 Introduction Infections can alter drug clearance, but the impact of inflammation-induced changes is still not well known. The aim of the investigation was to examine the effect of pathological C-reactive protein (CRP) values (≥0.5 mg/dL) and leukocyte count on the metabolism of 4 different atypical antipsychotics. Methods Steady-state serum concentrations of individual patients under therapy with risperidone (n=45), aripiprazole (n=30), olanzapine (n=24), and quetiapine (n=166) were retrospectively analyzed during a period of inflammation by Spearman’s Rho correla...
Source: Pharmacopsychiatry - March 26, 2019 Category: Psychiatry Authors: Scherf-Clavel, Maike Weidner, Anne Deckert, J ürgen Menke, Andreas Unterecker, Stefan Tags: Original Paper Source Type: research

Commercial Pharmacogenetic Tests in Psychiatry: Do they Facilitate the Implementation of Pharmacogenetic Dosing Guidelines?
Discussion Most commercial pharmacogenetic tests we examined are well-equipped to facilitate implementation of the majority of dosing guidelines relevant to psychiatry but are limited in their ability to facilitate implementation of the full spectrum of dosing guidelines currently available. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - March 21, 2019 Category: Psychiatry Authors: Fan, Mikayla Bousman, Chad A. Tags: Original Paper Source Type: research

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Pharmacopsychiatry 2019; 02 Article in Thieme eJournals: Table of contents  |  Congress (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 21, 2019 Category: Psychiatry Source Type: research

No Connection between Long-Term Lithium Treatment and Antithyroid Antibodies
Conclusion The results obtained showed no significant connection between long-term lithium treatment and antithyroid antibodies. In bipolar patients receiving lithium longitudinally, antithyroid antibodies can be associated with some indexes of thyroid function. However, they behave differently in male and female patients. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - February 7, 2019 Category: Psychiatry Authors: Kraszewska, Agnieszka Ziemnicka, Katarzyna Sowi ński, Jerzy Ferensztajn-Rochowiak, Ewa Rybakowski, Janusz K. Tags: Original Paper Source Type: research

Consider Role of Glutamatergic Habenula-projecting Globus Pallidus in OCD
Pharmacopsychiatry DOI: 10.1055/a-0835-6447Recently, in a review article in this journal, Vlček and colleagues described the putative role played by the glutamatergic system in obsessive-compulsive disorder (OCD) and how this might explain the effects of certain treatments. They describe a neuroanatomical model, which includes a specific role of the amygdala-hippocampus complex (AHC) and would complete the classic cortico-striatal-thalamo-cortical (CSTC) mechanism of OCD. The role of the AHC can perhaps be better understood when considering its ancient relationship to the rest of the forebrain of mammals. This leads to di...
Source: Pharmacopsychiatry - February 4, 2019 Category: Psychiatry Authors: Loonen, Anton J.M. Ivanova, Svetlana A. Tags: Letter to the Editor Source Type: research

Correlation Between Violence and Antipsychotic Dosage in Schizophrenia: A Secondary Analysis of The Clinical Antipsychotic Trials for Intervention Effectiveness (CATIE) Dataset
Discussion Violence in schizophrenia is associated with poor illness course. Further studies focusing on violence in younger non-white individuals are warranted. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 22, 2019 Category: Psychiatry Authors: Tasmim, Samia Kolla, Nathan J. Dada, Oluwagbenga Bani-Fatemi, Ali De Luca, Vincenzo Tags: Original Paper Source Type: research

A Big Thank You to Our Reviewers in the Past Year!
Pharmacopsychiatry 2019; 52: 5-6 DOI: 10.1055/a-0821-0656 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - January 10, 2019 Category: Psychiatry Tags: Acknowledgment to Reviewers Source Type: research

The Efficacy of Tiapride and Carbamazepine Combination Therapy in Reducing Alcohol Withdrawal Symptoms: A Systematic Review and Meta-Analysis
Pharmacopsychiatry DOI: 10.1055/a-0795-3689The combination of tiapride (TIA) and carbamazepine (CBZ) as an alternative treatment option to benzodiazepines and clomethiazole has been investigated by several investigations. We performed a systematic review and meta-analysis to further explore the efficacy of this combination in order to render more definite answers whether this combination can be recommendable in the clinical practice. We systematically searched electronic databases including PubMed (MEDLINE), EMBASE, OVID, Cochrane, Google Scholar, and Scopus for human studies. Statistical homogeneity was checked by χ2 ...
Source: Pharmacopsychiatry - December 6, 2018 Category: Psychiatry Authors: Latifi, Sahar Messer, Thomas Tags: Review Source Type: research

Obituary for Professor Hinderk Meiners Emrich, MD PhD
Pharmacopsychiatry DOI: 10.1055/a-0760-2100 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - December 3, 2018 Category: Psychiatry Authors: Leweke, F. Markus Bleich, Stefan Schneider, Udo Tags: Obituary Source Type: research

The Associations Between CYP2D6 Metabolizer Status and Pharmacokinetics and Clinical Outcomes of Venlafaxine: A Systematic Review and Meta-Analysis
Conclusions CYP2D6 metabolizer status had significant influence on venlafaxine pharmacokinetics, but insufficient evidence demonstrated that CYP2D6 metabolizer status was associated with its therapeutic effects and overall rate of adverse events, which provided further evidence regarding the relationship between CYP2D6 metabolizer status and venlafaxine. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 28, 2018 Category: Psychiatry Authors: Lin, Xiao-Qian Wang, Ping Cai, Wen-Ke Xu, Gui-Li Yang, Mei Zhou, Meng-Di Sun, Mei He, Fang He, Gong-Hao Tags: Original Paper Source Type: research

Studies of Half-Lives of Long-Acting Antipsychotics are Needed
Pharmacopsychiatry DOI: 10.1055/a-0755-7692 © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - October 22, 2018 Category: Psychiatry Authors: Schoretsanitis, Georgios Villasante-Tezanos, Alejandro G. de Leon, Jose Tags: Letter to the Editor Source Type: research

Comparing Schizophrenia Patients With a Predicted High/Low Risk of Nonresponse Receiving Treatment with Ziprasidone and Haloperidol: A Randomized-Controlled Study
Discussion An alarmingly high number of patients were at high risk of nonresponse to antipsychotic treatment. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 20, 2018 Category: Psychiatry Authors: Schennach, Rebecca Riedel, Michael Spellmann, Ilja Musil, Richard Obermeier, Michael J äger, Markus Bottlender, Roland Schmauss, Max Laux, Gerd M öller, Hans-Jürgen Tags: Original Paper Source Type: research

Augmentation of Pharmacotherapy by Sleep Deprivation with Sleep Phase Advance in Treatment-Resistant Depression
Discussion Our preliminary study demonstrated the efficacy of pharmacotherapy augmentation by TSD and SPA in half of the patients with TRD. The main biochemical factors related to clinical response included status of cortisol and increase in IL-10 and IL-1β levels. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - September 10, 2018 Category: Psychiatry Authors: Kurczewska, Ewa Ferensztajn-Rochowiak, Ewa Jasi ńska-Mikołajczyk, Anna Ch łopocka-Woźniak, Maria Rybakowski, J. K. Tags: Original Paper Source Type: research