Bibliometric and visualized analysis of type 2 diabetic osteoporosis from 2013 to 2022
ConclusionThis was the first bibliometric study of diabetes mellitus and osteoporosis to exclusively examine type 2 diabetes mellitus. Our findings would provide guidance to understand the research frontiers and hot directions in the near future. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - April 22, 2024 Category: Orthopaedics Source Type: research
The current landscape for diabetes treatment: Preventing diabetes-associated CV risk
Despite the risk of atherosclerosis has progressively declined over the past few decades, subjects with type 2 diabetes mellitus (T2DM) continue to experience substantial excess of atherosclerotic cardiovascular disease (ASCVD)-related events. Therefore, there is urgent need to treat ASCVD disease in T2DM earlier, more intensively, and with greater precision. Many factors concur to increase the risk of atherosclerosis, and multifactorial intervention remains the basis for effective prevention or reduction of atherosclerotic events. (Source: Atherosclerosis)
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Angela Dardano, Cristina Bianchi, Monia Garofolo, Stefano Del Prato Source Type: research
Serum brain-derived neurotrophic factor levels in type 2 diabetes mellitus patients and its association with cognitive impairment: A meta-analysis
by Wan-li He, Fei-xia Chang, Tao Wang, Bi-xia Sun, Rui-rong Chen, Lian-ping Zhao
ObjectiveTo compare the serum levels of brain-derived neurotrophic factor (BDNF) in type 2 diabetes mellitus (T2DM) patients with healthy controls (HC) and evaluate the BDNF levels in T2DM patients with/without cognitive impairment. MethodsPubMed, EMBASE, and the Cochrane Library databases were searched for the published English literature on BDNF in T2DM patients from inception to December 2022. The BDNF data in the T2DM and HC groups were extracted, and the study quality was evaluated using the Agency for Healthcare Research and Quality. A m...
Source: PLoS One - April 22, 2024 Category: Biomedical Science Authors: Wan-li He Source Type: research
Molecules, Vol. 29, Pages 1904: Molecular Dynamics Simulation of Kir6.2 Variants Reveals Potential Association with Diabetes Mellitus
In this study, we examined the effect of mutations on the Kir6.2 structure using bioinformatics tools and molecular dynamic simulations (SIFT, PolyPhen, SNAP2, PANTHER, PhD&SNP, SNP&Go, I-Mutant, MuPro, MutPred, ConSurf, HOPE, and GROMACS). Our results indicated that M199R, R201H, R206H, and Y330H mutations influence Kir6.2 structure and function and therefore may cause DM. We conclude that MD simulations are useful techniques to predict the effects of mutations on protein structure. In addition, the M199R, R201H, R206H, and Y330H variant in the Kir6.2 protein may be associated with DM. These result...
Source: Molecules - April 22, 2024 Category: Chemistry Authors: Mohamed E. Elangeeb Imadeldin Elfaki Ali M. S. Eleragi Elsadig Mohamed Ahmed Rashid Mir Salem M. Alzahrani Ruqaiah I. Bedaiwi Zeyad M. Alharbi Mohammad Muzaffar Mir Mohammad Rehan Ajmal Faris Jamal Tayeb Jameel Barnawi Tags: Article Source Type: research
Bibliometric and visualized analysis of type 2 diabetic osteoporosis from 2013 to 2022
ConclusionThis was the first bibliometric study of diabetes mellitus and osteoporosis to exclusively examine type 2 diabetes mellitus. Our findings would provide guidance to understand the research frontiers and hot directions in the near future. (Source: Archives of Orthopaedic and Trauma Surgery)
Source: Archives of Orthopaedic and Trauma Surgery - April 22, 2024 Category: Orthopaedics Source Type: research
Folic acid supplementation on inflammation and homocysteine in type 2 diabetes mellitus: systematic review and meta-analysis of randomized controlled trials
Nutrition & Diabetes, Published online: 22 April 2024; doi:10.1038/s41387-024-00282-6Folic acid supplementation on inflammation and homocysteine in type 2 diabetes mellitus: systematic review and meta-analysis of randomized controlled trials (Source: Nutrition and Diabetes)
Source: Nutrition and Diabetes - April 22, 2024 Category: Nutrition Authors: Kabelo Mokgalaboni Given. R. Mashaba Wendy N. Phoswa Sogolo. L. Lebelo Source Type: research
Associations between resting energy expenditure and glycemic parameters in women with obesity without type 2 diabetes mellitus
(Source: Clinical Nutrition)
Source: Clinical Nutrition - April 22, 2024 Category: Nutrition Authors: Mateus de Lima Macena, Micn éias Roberth Pereira, Déborah Tenório Costa de Paula, André Eduardo da Silva Júnior, Nassib Bezerra Bueno Source Type: research
Efficacy and safety of glucagon-like peptide-1 receptor agonists in the elderly versus non-elderly patients with type 2 diabetes mellitus: insights from a systematic review
In conclusion, while certain AEs leading to discontinuation may be more prevalent in older patients, GLP-1RAs are effective for weight loss and lead to decreased glucose concentrations with a low rate of complications in elderly patients.PMID:38644220 | DOI:10.1507/endocrj.EJ23-0384 (Source: Endocrine Journal)
Source: Endocrine Journal - April 21, 2024 Category: Endocrinology Authors: Yao Wang Jiangling Wang Qian Gong Haoming Wu Shuhao Yang Jufeng He Xulin Hu Tianfang Huang Source Type: research
Molecular mechanisms linking type 2 diabetes mellitus and late-onset Alzheimer's disease: A systematic review and qualitative meta-analysis
Neurobiol Dis. 2024 Apr 19:106485. doi: 10.1016/j.nbd.2024.106485. Online ahead of print.ABSTRACTResearch evidence indicating common metabolic mechanisms through which type 2 diabetes mellitus (T2DM) increases risk of late-onset Alzheimer's dementia (LOAD) has accumulated over recent decades. The aim of this systematic review is to provide a comprehensive review of common mechanisms, which have hitherto been discussed in separate perspectives, and to assemble and evaluate candidate loci and epigenetic modifications contributing to polygenic risk linkages between T2DM and LOAD. For the systematic review on pathophysiologica...
Source: Neurobiology of Disease - April 21, 2024 Category: Neurology Authors: Erwin Lemche Richard Killick Jackie Mitchell Paul W Caton Pratik Choudhary Jane K Howard Source Type: research
Efficacy and safety of glucagon-like peptide-1 receptor agonists in the elderly versus non-elderly patients with type 2 diabetes mellitus: insights from a systematic review
In conclusion, while certain AEs leading to discontinuation may be more prevalent in older patients, GLP-1RAs are effective for weight loss and lead to decreased glucose concentrations with a low rate of complications in elderly patients.PMID:38644220 | DOI:10.1507/endocrj.EJ23-0384 (Source: Endocrine Journal)
Source: Endocrine Journal - April 21, 2024 Category: Endocrinology Authors: Yao Wang Jiangling Wang Qian Gong Haoming Wu Shuhao Yang Jufeng He Xulin Hu Tianfang Huang Source Type: research
Miniature mass spectrometer-based point-of-care assay for quantification of metformin and sitagliptin in human blood and urine
This study developed a point-of-care (POC) assay method utilizing a miniature mass spectrometer, enabling rapid and accurate quantification of MET and STG concentrations in human blood and urine. By combining the miniature mass spectrometer with paper spray ionization, this method simplifies the process into three to four steps, requires minimal amounts of bodily fluids (50 μL of blood and 2 μL of urine), and is able to obtain quantification results within approximately 2 min. Stable isotope-labeled internal standards were employed to enhance the accuracy and stability of measurement. The MS/MS responses exhibited good l...
Source: Analytical and Bioanalytical Chemistry - April 20, 2024 Category: Chemistry Authors: Jingying Chen Yaohan Li Jingjing Chen Ruimin Wang Miaoshan Lu Changbin Yu Source Type: research
Valuing the health benefits of nature-based recreational physical activity in England
Environ Int. 2024 Apr 16;187:108667. doi: 10.1016/j.envint.2024.108667. Online ahead of print.ABSTRACTPhysical activity (PA) reduces the risk of several non-communicable diseases (NCDs). Natural environments support recreational PA. Using data including a representative cross-sectional survey of the English population, we estimated the annual value of nature-based PA conducted in England in 2019 in terms of avoided healthcare and societal costs of disease. Population-representative data from the Monitor of Engagement with the Natural Environment (MENE) survey (n = 47,580; representing 44,386,756) were used to estimate the ...
Source: Environment International - April 20, 2024 Category: Environmental Health Authors: James Grellier Mathew P White Si ân de Bell Oscar Brousse Lewis R Elliott Lora E Fleming Clare Heaviside Charles Simpson Tim Taylor Benedict W Wheeler Rebecca Lovell Source Type: research
Gastrodin alleviates the deterioration of depressive-like behavior and glucolipid metabolism promoted by chronic stress in type 2 diabetic mice
In this study, we performed 5 weeks CUMS intervention and simultaneously administered gastrodin (140 mg/kg, once daily) on T2DM mice, to investigate the potential protective effects of gastrodin. The protective effect of gastrodin was evaluated by behavioral tests, biochemical analysis, histopathological examination, RT-qPCR and gut microbiota analysis. We found that the depressive-like behavior and glucolipid metabolism could be deteriorated by chronic stress in type 2 diabetic mice, while gastrodin showed a protective effect against these exacerbations by regulating HPA hormones, activating FXR and Cyp7a1, reducing infla...
Source: European Journal of Pharmacology - April 20, 2024 Category: Drugs & Pharmacology Authors: Canye Li Jinming Cao Zhicong Chen Zuanjun Su Huimin Bao Xue Li Luping Liu Zhijun Xiao Jingjing Duan Ting Zhou Feng Xu Source Type: research
Glucose Color Index: Development and Validation of a Novel Measure of the Shape of Glycemic Variability
CONCLUSION: We developed and validated the GCI, a novel CGM metric that captures the shape of glucose variability using the periodogram signal decomposition. Glucose Color Index was reliable within participants over a three-month period and associated with diabetes comorbidities. The GCI suggests a promising avenue toward the development of CGM metrics which more fully incorporate time series information.PMID:38641966 | DOI:10.1177/19322968241245654 (Source: Atherosclerosis)
Source: Atherosclerosis - April 20, 2024 Category: Cardiology Authors: Joseph Sartini Michael Fang Mary R Rooney Elizabeth Selvin Josef Coresh Scott Zeger Source Type: research
Obesity Differs from Diabetes Mellitus in Antibody and T Cell Responses Post COVID-19 Recovery
This study aims to investigate the humoral and cellular immune responses to SARS-CoV-2 in adult COVID-19 survivors with obesity and DM in Bangladesh. In this cross-sectional study, SARS-CoV-2-specific antibody and T cell responses were investigated in 63 healthy and 75 PCR-confirmed COVID-19 recovered individuals in Bangladesh, during the pre-vaccination first wave of the COVID-19 pandemic in 2020. In COVID-19 survivors, SARS-CoV-2 infection induced robust antibody and T cell responses, which correlated with disease severity. After adjusting for age, sex, DM status, disease severity, and time since onset of symptoms, obesi...
Source: Clinical and Developmental Immunology - April 20, 2024 Category: Allergy & Immunology Authors: Mohammad Ali Stephanie Longet Isabel Neale Patpong Rongkard Forhad Uddin Hassan Chowdhury Jennifer Hill Anthony Brown Stephen Laidlaw Tom Tipton Ashraful Hoque Nazia Hassan Carl-Philipp Hackstein Sandra Adele Hossain Delowar Akther Priyanka Abraham Shreba Source Type: research
