Real-world cost-effectiveness of denosumab for the treatment of postmenopausal osteoporosis in Taiwan
ConclusionIn a real-world setting, at a cost per QALY threshold equivalent to gross domestic product per capita in 2020 in Taiwan (USD $30,038), continued treatment with denosumab in postmenopausal women with osteoporosis is cost-effective compared with treatment discontinuation. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - October 12, 2021 Category: Orthopaedics Source Type: research

Bibliometric analysis of global research trends on male osteoporosis: a neglected field deserves more attention
ConclusionsThis is the first bibliometric analysis that provides a comprehensive overview of male osteoporosis research, which may provide helpful references for investigators to further explore hot issues in this field. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - October 11, 2021 Category: Orthopaedics Source Type: research

Application of deep learning neural network in predicting bone mineral density from plain X-ray radiography
This study explored the possibility of predicting BMD relative to DXA using patient radiographs.MethodsA deep learning algorithm of convolutional neural network (CNN) was used for the purpose. The method includes image segmentation, CNN learning, and a convolution-based regression model (DeepDXA) that links the isolated images of the femur bone to predict BMD value. Data were obtained in a single medical center from 2006 to 2018, with a total amount of 3472 pairs of pelvis X-ray and DXA examination within 1  year.ResultsThe proposed workflow successfully predicted BMD values of the femur bone with the correlation coef...
Source: Archives of Osteoporosis - October 9, 2021 Category: Orthopaedics Source Type: research

Osteoporosis awareness among patients in Singapore (OASIS) —a community hospital perspective
This study examines factors associated with osteoporosis awareness and knowledge using Osteoporosis Prevention and Awareness Tool (OPAAT). Of 410 patients, majority of patients had a OPAAT score  
Source: Archives of Osteoporosis - October 8, 2021 Category: Orthopaedics Source Type: research

Quality indicators in the treatment of geriatric hip fractures: literature review and expert consensus
ConclusionWe suggest the QIs for RR-FHF to be practice tested and adapted to allow for intra-hospital longitudinal follow-up of the quality of care and for inter-hospital and cross-country benchmarking and quality improvement initiatives. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - October 8, 2021 Category: Orthopaedics Source Type: research

Incidence rate of osteoporotic hip fracture in Qatar
ConclusionThe annual age-adjusted standardized IR of OHF per 100,000 inhabitants aged  ≥ 50 years in Qatar was comparable to that in regional countries, and lower than that in North America and European countries. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - October 5, 2021 Category: Orthopaedics Source Type: research

Age-related changes and reference intervals of RANKL, OPG, and bone turnover markers in Indian women
ConclusionWe reported menopausal status –based and age-related reference intervals for serum RANKL, OPG, RANKL/OPG ratio, and CTX and PINP in healthy Indian women. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - October 4, 2021 Category: Orthopaedics Source Type: research

Teriparatide in individuals with a prior history of radiation therapy —a case series
ConclusionDespite radiotherapy being a relative contraindication to teriparatide use, there may be a role for teriparatide in select cases where osteoporosis is complex and severe and where other treatment options are not suitable or have been exhausted. The risks vs. benefits of prescribing teriparatide in this population should always be carefully considered, and both the patient and treating oncologist should be educated on the potential risk of osteosarcoma development when teriparatide is continued during radiotherapy. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - October 4, 2021 Category: Orthopaedics Source Type: research

Sociodemographic and health system factors associated with variations in hospitalization costs for fractures in adults aged 45  years and over: a cross-sectional study of provincial health accounts in Jiangsu Province, China
ConclusionOur study reports hospital costs of the fracture using a large health accounts database in China and investigates the associated factors of hospital costs. Our results may inform cost-of-illness studies and economic evaluations of fracture preventions. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - October 4, 2021 Category: Orthopaedics Source Type: research

Annual out-of-pocket expenditure associated with healthcare use among Australian older women with osteoporosis: a cross-sectional study
ConclusionsWomen with osteoporosis use a wide range of healthcare services that are associated with significant annual out-of-pocket expenditure. Preventive strategies can help decrease the cost burden of osteoporosis on the healthcare system. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - October 4, 2021 Category: Orthopaedics Source Type: research

Asymptomatic vertebral fracture in Tunisian post-menopausal women at risk: prevalence and risk factors
ConclusionVF are very prevalent among at risk Tunisian post-menopausal women and their incorporation in a clinical and densitometric tool might identify more effectively subsequent fracture. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - September 19, 2021 Category: Orthopaedics Source Type: research

Biochemical characteristics and calcium and PTH levels of patients with high normal and elevated serum 25(OH)D levels in Turkey: DeVIT-TOX survey
AbstractSummaryVitamin D intake over the recommended dose is usually associated with high serum 25(OH)D levels and generally not associated with symptoms of hypercalcemia. High doses of cholecalciferol need to be avoided to protect against vitamin D toxicity and related complications. Strict adherence to the clinical guidelines for treating vitamin D deficiency can ensure safe and effective treatment.PurposeWe observed a tendency to use high doses of cholecalciferol for vitamin D deficiency treatment or vitamin D supplementation. We aimed to determine the biochemical characteristics of patients with high normal and elevate...
Source: Archives of Osteoporosis - September 18, 2021 Category: Orthopaedics Source Type: research

Association between bone measures and use of angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers
AbstractSummaryAngiotensin-converting enzyme inhibitor use in women was associated with lower femoral neck and lumbar spine bone mineral density as well as trabecular bone score compared to non-users. No differences were identified for men or for those who used ARB medications.PurposeMany individuals at high fracture risk use medications such as angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) that could affect bone; thus, this study aimed to investigate whether there are any differences in bone mineral density (BMD) and trabecular bone score (TBS) between ACEI users, ARB users, and...
Source: Archives of Osteoporosis - September 18, 2021 Category: Orthopaedics Source Type: research

Accounts of health risk assessment survey administration in the Catch a Break Program: the social construction of osteoporosis risk identification and need for intervention
ConclusionWe uncovered areas in the screening interaction that were talked about by staff as problematic to achieving the program objective of identifying and enrolling individuals in the secondary fracture prevention program. By highlighting areas for improvement in program delivery, this study may help to reduce the interactional troubles staff negotiate as they deliver this type of program. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - September 17, 2021 Category: Orthopaedics Source Type: research

Correction to: Alendronate use and bone mineral density gains in women with moderate-severe (stages 3B –5) chronic kidney disease: an open cohort multivariable and propensity score analysis from Funen, Denmark
(Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - September 17, 2021 Category: Orthopaedics Source Type: research

Trabecular bone score and bone mineral density in acromegalic osteopathy assessment: a cross-sectional study
AbstractPurpose The evaluation of acromegalic osteopathy is a subject of current interest as there is a lack of evidence concerning proper evaluation techniques and clear diagnostic criteria. The aim of this study was to evaluate lumbar spine trabecular bone score (TBS) and bone mineral density (BMD) in acromegaly patients compared to healthy controls.MethodsWe conducted a cross-sectional study on 43 acromegaly patients recruited between 2018 and 2020 and a healthy control group matched 1:1 for age, gender, and body mass index (BMI). All subjects underwent DXA, lumbar spine TBS, and bone turnover markers measurement.Resu...
Source: Archives of Osteoporosis - September 16, 2021 Category: Orthopaedics Source Type: research

Discontinuation of bisphosphonates in seniors: a systematic review on health outcomes
ConclusionBisphosphonates have successfully been discontinued low overall fracture risk after at least 3 years of use, but a risk for decreased BMD and increased vertebral fractures remained. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - September 15, 2021 Category: Orthopaedics Source Type: research

Insufficient persistence to pharmacotherapy in Japanese patients with osteoporosis: an analysis of the National Database of Health Insurance Claims and Specific Health Checkups in Japan
ConclusionIn Japan, persistence and the 2-year MPR were inadequate in increasing fracture control efficacy despite a high adherence rate during the treatment period. To bridge the care gap following osteoporosis pharmacotherapy, improvements are required for males, the elderly, and those without polypharmacy. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - September 13, 2021 Category: Orthopaedics Source Type: research

Predictive factors of non-treatment and non-persistence to osteoporosis medication after fragility hip fractures at 3  years after discharge: a multicentre, prospective cohort study in the northern Kyushu district of Japan
ConclusionLow BI at discharge is a risk factor for both non-treatment and non-persistence to osteoporosis medication. Therefore, appropriate interventions to improve BI may result in persistence to osteoporosis medication. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - September 13, 2021 Category: Orthopaedics Source Type: research

The reliability and validity of the Turkish version of the Quality of Life Questionnaire of the European Foundation for Osteoporosis-31 (QUALEFFO-31)
ConclusionThe Turkish version of QUALEFFO-31 has a sufficient level of reliability, validity, and psychometric properties. Nevertheless, improvements in pain and mental function domains and some changes applying to the model may increase the psychometric capacity of the questionnaire. The questionnaire, which is potentially capable of differentiating patients with fractures, does not appear to have the differential capacity in terms of osteoporosis.ClinicalTrials.gov identifierNCT04259099 (date of registration: February 6, 2020) (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - September 9, 2021 Category: Orthopaedics Source Type: research

Fragility fracture of the fourth rib in a patient with a cardiac pacemaker: an uncommon case
ConclusionPacemaker implantation might have caused shoulder dysfunction and pectoral tightness resulting in reduced flexibility of the trunk. Consequently, a reaching motion of the arm with a trunk rotation might have directed rotational force vectors towards the osteopenic left 4th rib causing a fragility fracture. In elderly with a pacemaker, osteopenia and concomitant sarcopenia may create a predisposition to this atypical complication. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - September 9, 2021 Category: Orthopaedics Source Type: research

Association between vitamin D and bone mineral density in Japanese adults: the Unzen study
AbstractSummaryWe showed an association between serum concentrations of vitamin D and bone health among community-dwelling adults in Japan after adjustment for confounding factors, with 730 participants in a city, with concentrations of 25(OH) vitamin D, and with parameters of quantitative ultrasound.PurposeThe primary objective of this study was to examine the correlation between serum 25-hydroxyvitamin D (25(OH)D) concentration and bone indicators as measured by quantitative ultrasound in middle-aged and older Japanese adults living in low-latitude seaside areas during summer and autumn.MethodsWe conducted a cross-sectio...
Source: Archives of Osteoporosis - September 8, 2021 Category: Orthopaedics Source Type: research

Performance of HR-pQCT, DXA, and FRAX in the discrimination of asymptomatic vertebral fracture in postmenopausal Chinese women
ConclusionTb.vBMD at the radius and SMI at the tibia provided by HR-pQCT can discriminate asymptomatic VF independent of hip aBMD and FRAXBMD by DXA in postmenopausal women. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - September 4, 2021 Category: Orthopaedics Source Type: research

The clinical and economic burden after an osteoporosis fracture in France: a nationwide population-based study
ConclusionSubsequent fractures among osteoporotic participants with an initial fracture result in increased clinical mortality and high healthcare resource use. Emphasis should be placed on the prevention of recurrent fractures. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - August 26, 2021 Category: Orthopaedics Source Type: research

Menarche age exceed 17  years and menopausal age smaller than 48 years may affect prevalence of osteoporosis for Chinese women
ConclusionsIn China, ages at menarche and menopause are associated with prevalence of osteoporosis. Later, menarche and earlier menopause are associated with higher osteoporosis risk. Menarche and menopause history may help identify women with increased risk of developing osteoporosis. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - August 24, 2021 Category: Orthopaedics Source Type: research

Handgrip strength is positively associated with bone mineral density in middle and aged adults: results from NHANES 2013 –2014
We examined the associations of handgrip strength with BMD in 2720 adults (1359 men and 1361 women) aged  ≥ 40 years (mean age, 58.6 ± 11.8 years) from the National Health and Nutrition Examination Survey (NHANES) 2013–2014. NHANES collects data via household interviews and direct standardized physical examinations conducted in specially equipped mobile examination centers. The date of f inal data collection was 2014 and the present data analysis was conducted in January to February 2020.ResultsHandgrip strength was significantly associated with total femur (r =&...
Source: Archives of Osteoporosis - August 18, 2021 Category: Orthopaedics Source Type: research

Examining trajectories of hospital readmission in older adults hospitalised with hip fracture from residential aged care and the community
ConclusionHealth service use trajectories differed for RACF residents and community-dwellers; however, there were similar patient characteristics that defined trajectory group membership. Low users of hospital services living in RACFs or the community included older adults with generally unfavourable health conditions, potentially indicating that palliative care or advanced care directives and community-care initiatives, respectively, have played a part in the lowered frequency of rehospitalisation. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - August 17, 2021 Category: Orthopaedics Source Type: research

Evaluation of care delivery by a novel multidisciplinary bone health clinic for patients at risk of glucocorticoid-induced osteoporosis
ConclusionOur novel GIOP clinic model successfully fills a gap in osteoporosis care by providing multidisciplinary intervention in key components of GIOP preventive care to an underserved patient population. Further studies are required to assess the real-world long-term outcomes of our model. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - July 7, 2021 Category: Orthopaedics Source Type: research

Effect of unfocused extracorporeal shockwave therapy on bone mineral content of twelve distal forearms of postmenopausal women: a clinical pilot study
ConclusionsUnfocused extracorporeal shockwave therapy is a safe treatment, but no increase in bone mass on the forearm was found at 0.3  mJ/mm2 energy flux density. In this study, we were not able to demonstrate that a single treatment with unfocused shockwave therapy in unselected patients had any effect in terms of bone mineral density (BMD) or bone mineral content (BMC). A power analysis indicated that 174 patients per group are required to show an effect size of 0.3 with a power of 80%. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - November 25, 2019 Category: Orthopaedics Source Type: research

Trends in and relation between hip fracture incidence and osteoporosis medication utilization and prices in Estonia in 2004 –2015
AbstractSummaryOsteoporosis medicines reduce osteoporotic fractures. There is a very strong negative correlation between the consumption of medicines and the price of an average daily dose indicating that affordability is a key factor that could increase consumption of antiosteoporotic medicines and, through that, reduce fractures.PurposeOsteoporosis is a major cause of morbidity and mortality in the modern world. Our study aims to describe the trends in incidence of hip fractures in relation to drug utilization patterns and the average price of antiosteoporotic medicines in Estonia.MethodsData on hip fractures was obtaine...
Source: Archives of Osteoporosis - May 11, 2017 Category: Orthopaedics Source Type: research

Prevalence and risk factors associated with glucocorticoid-induced osteoporosis in Chinese patients with rheumatoid arthritis
ConclusionsGIOP exists generally in Chinese patients with RA, which relates to treatment course not daily dosage of GC. Usage of GC is also the risk factor for the happening of OPF in Chinese patients with RA. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - April 3, 2017 Category: Orthopaedics Source Type: research

Thiazide increases serum calcium in anuric patients: the role of parathyroid hormone
AbstractSummaryWe evaluated the effect of hydrochlorothiazide in a sample of anuric patients on hemodialysis and found an increase in serum calcium, which occurred only in those with parathyroid hormone>300  pg/ml. This finding highlights the extra-renal effect of this diuretic and a possible role of parathyroid hormone in the mechanism.PurposeThiazide diuretics are commonly used in patients with chronic kidney disease to treat hypertension. Their effects on calcium and bone metabolism are not well established, once calciuria may not fully explain levels of calcium and parathyroid hormone (PTH) in this population. ...
Source: Archives of Osteoporosis - March 25, 2017 Category: Orthopaedics Source Type: research

Low prevalence of osteoporosis treatment in patients with recurrent major osteoporotic fracture
AbstractSummaryThe majority of patients do not receive anti-osteoporotic treatment following a major osteoporotic fracture, despite the guidelines and the availability of effective anti-osteoporotic treatments. The fight against factors limiting the diagnosis and treatment of osteoporosis should become a priority to improve secondary prevention after an initial osteoporotic fracture.PurposeDespite the availability of effective anti-osteoporotic treatments, osteoporosis management is currently insufficient. The main objective of this study was to assess the prevalence of anti-osteoporotic treatments introduced after an init...
Source: Archives of Osteoporosis - February 28, 2017 Category: Orthopaedics Source Type: research

Vertebral fracture assessment in patients presenting with a non-hip non-vertebral fragility fracture: experience of a UK Fracture Liaison Service
This study aims to identify the prevalence of undiagnosed VFF in patients presenting with a non-hip non-vertebral fragility fracture.MethodsPatients identified by the fracture liaison service (FLS) of a large UK university hospital presenting with a non-hip non-vertebral fragility fracture were evaluated from 1 January 2012 to 30 September 2015. Local protocol identified those that would proceed for VFA. Data was collected on patient characteristics, fracture details, bone mineral density (BMD) measurements and VFA results.ResultsFive hundred sixty-seven patients (mean (SD) age, 72 (9.4) years) of mostly women (88.3%) had ...
Source: Archives of Osteoporosis - February 27, 2017 Category: Orthopaedics Source Type: research

Improving patient outcomes in fibrous dysplasia/McCune-Albright syndrome: an international multidisciplinary workshop to inform an international partnership
ConclusionsIn spite of advances in understanding the genetic and molecular underpinnings of fibrous dysplasia/McCune-Albright syndrome, clinical management remains a challenge. From the workshop, a consensus was reached to create an international, multi-stakeholder partnership to advance research and clinical care in FD/MAS. We invite other stakeholders to join the partnership. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - February 26, 2017 Category: Orthopaedics Source Type: research

Persistence with denosumab and zoledronic acid among older women: a population-based cohort study
ConclusionThe persistence rate to denosumab and zoledronic acid was higher to the published data of oral bisphosphonates. The second intention of treatment seems to target more severe patients which may more likely to be compliant. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - September 26, 2016 Category: Orthopaedics Source Type: research

Low self-awareness of osteoporosis and fracture risk among postmenopausal women
ConclusionThese results show that postmenopausal women underestimate their risk of osteoporotic fractures when compared with their 10-year fracture risk according to FRAX algorithm. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - August 7, 2016 Category: Orthopaedics Source Type: research

In Memoriam: Pierre J. Meunier
(Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - June 19, 2016 Category: Orthopaedics Source Type: research

Secondary prevention of osteoporosis following fragility fractures of the distal radius in a large health maintenance organization
Conclusions Patients were unlikely to receive appropriate evaluation and treatment for secondary prevention of fragility fractures in our system. A system-based treatment plan for the prevention of osteoporosis should be implemented. Since distal radius fractures occur early in osteoporosis, these fractures should be targeted for secondary prevention. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - May 2, 2016 Category: Orthopaedics Source Type: research

A new implementation of digital X-ray radiogrammetry and reference curves of four indices of cortical bone for healthy European adults
Conclusion The new DXR method is an extension of the existing BoneXpert method for children, which allows patients to be followed from childhood into adulthood with the same method. By making all four indices of cortical bone available within the same medical device, it becomes possible to decide which index has the best relation to fracture risk in future studies. (Source: Archives of Osteoporosis)
Source: Archives of Osteoporosis - April 25, 2016 Category: Orthopaedics Source Type: research