Obesity Differs from Diabetes Mellitus in Antibody and T Cell Responses Post COVID-19 Recovery
This study aims to investigate the humoral and cellular immune responses to SARS-CoV-2 in adult COVID-19 survivors with obesity and DM in Bangladesh. In this cross-sectional study, SARS-CoV-2-specific antibody and T cell responses were investigated in 63 healthy and 75 PCR-confirmed COVID-19 recovered individuals in Bangladesh, during the pre-vaccination first wave of the COVID-19 pandemic in 2020. In COVID-19 survivors, SARS-CoV-2 infection induced robust antibody and T cell responses, which correlated with disease severity. After adjusting for age, sex, DM status, disease severity, and time since onset of symptoms, obesity was associated with decreased neutralising antibody titers, and increased SARS-CoV-2 spike-specific IFN-γ response along with increased proliferation and IL-2 production by CD8+ T cells. In contrast, DM was not associated with SARS-CoV-2-specific antibody and T cell responses after adjustment for obesity and other confounders. Obesity is associated with lower neutralising antibody levels and higher T cell responses to SARS-CoV-2 post COVID-19 recovery, while antibody or T cell responses remain unaltered in DM.PMID:38642547 | DOI:10.1093/cei/uxae030
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Mohammad Ali Stephanie Longet Isabel Neale Patpong Rongkard Forhad Uddin Hassan Chowdhury Jennifer Hill Anthony Brown Stephen Laidlaw Tom Tipton Ashraful Hoque Nazia Hassan Carl-Philipp Hackstein Sandra Adele Hossain Delowar Akther Priyanka Abraham Shreba Source Type: research
More News: Allergy & Immunology | Bangladesh Health | Covid Vaccine | COVID-19 | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Eating Disorders & Weight Management | Endocrinology | Obesity | Pandemics | SARS | Study | Vaccines