The value of lipid accumulation products in predicting type 2 diabetes mellitus: a cross-sectional study on elderlies over 65 in Shanghai
ConclusionLAP is more significantly associated with the risk of T2DM in elderlies than FPG, UN or NC, and it serves as a strong predictor of T2DM. However, this is impacted by FPG and neck circumference to a certain extent. Future large-scale studies are needed to confirm its efficacy in predicting diabetes. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Association of common single-nucleotide polymorphism of HHEX with type 2 diabetes mellitus
ConclusionOur study revealed that polymorphisms rs7923837 ofHHEX were not associated with T2DM. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Inflammation and immunological disarrays are associated with acute exercise in type 2 diabetes
ConclusionFinally; JUN, IL6, IL1B, PTGS2, FOS, ATF3, CXCL8, EGR1, and EGR2 were introduced as the critical targeted genes by exercise. Since the critical genes after exercise are upregulated and mostly are known as the risk factors of T2D, it can be concluded that unsuitable exercise can develop diabetic conditions in patients. Acute exercise-induced inflammation and immune disturbances seem to be associated with the development of T2D in patients. (Source: Journal of Diabetes and Metabolic Disorders)
Source: Journal of Diabetes and Metabolic Disorders - April 18, 2024 Category: Endocrinology Source Type: research
Time to clinical benefit with sotagliflozin in patients with type 2 diabetes and chronic kidney disease: Insights from the SCORED randomized trial
(Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 17, 2024 Category: Cardiology Authors: Rahul Aggarwal,
Deepak L. Bhatt,
Michael Szarek,
Lawrence A. Leiter,
Christopher P. Cannon,
Renato D. Lopes,
Michael J Davies,
Phillip Banks,
Bertram Pitt,
Ph. Gabriel Steg Tags: Research Letter Source Type: research
A Comprehensive Review on GLP-1 Signaling Pathways in the Management of Diabetes Mellitus - Focus on the Potential Role of GLP-1 Receptors Agonists and Selenium Among Various Organ Systems
Curr Diabetes Rev. 2024 Apr 16. doi: 10.2174/0115733998287178240403055901. Online ahead of print.ABSTRACTDiabetes Mellitus develops when the body becomes unable to fuel its cells with glucose, which results in the accumulation of sugar excess in the bloodstream. Because it has diverse pathophysiological impacts on the body, diabetes mellitus represents a significant issue of concern in an attempt to find suitable treatment modalities and medications for afflicted diabetic patients. Glucagon-like peptide 1 (GLP-1) plays a pivotal role in the incretin effect, emerging as a prospective treatment for diabetes mellitus and a pr...
Source: Current Diabetes Reviews - April 17, 2024 Category: Endocrinology Authors: Ghinwa Barakat Ghaith Assi Hussein Khalil Sami El Khatib Source Type: research
A Comprehensive Review on GLP-1 Signaling Pathways in the Management of Diabetes Mellitus - Focus on the Potential Role of GLP-1 Receptors Agonists and Selenium Among Various Organ Systems
Curr Diabetes Rev. 2024 Apr 16. doi: 10.2174/0115733998287178240403055901. Online ahead of print.ABSTRACTDiabetes Mellitus develops when the body becomes unable to fuel its cells with glucose, which results in the accumulation of sugar excess in the bloodstream. Because it has diverse pathophysiological impacts on the body, diabetes mellitus represents a significant issue of concern in an attempt to find suitable treatment modalities and medications for afflicted diabetic patients. Glucagon-like peptide 1 (GLP-1) plays a pivotal role in the incretin effect, emerging as a prospective treatment for diabetes mellitus and a pr...
Source: Current Diabetes Reviews - April 17, 2024 Category: Endocrinology Authors: Ghinwa Barakat Ghaith Assi Hussein Khalil Sami El Khatib Source Type: research
A systematic review of the effect of semaglutide on lean mass: insights from clinical trials
CONCLUSION: Semaglutide displays potential for weight loss primarily through fat mass reduction. However, concerns arise from notable reductions in lean mass, especially in trials with a larger number of patients.PMID:38629387 | DOI:10.1080/14656566.2024.2343092 (Source: Expert Opinion on Pharmacotherapy)
Source: Expert Opinion on Pharmacotherapy - April 17, 2024 Category: Drugs & Pharmacology Authors: Alexia Bikou Foteini Dermiki-Gkana Michail Penteris Theodoros K Constantinides Christos Kontogiorgis Source Type: research
The paradox of fatty-acid β-oxidation in muscle insulin resistance: Metabolic control and muscle heterogeneity
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167172. doi: 10.1016/j.bbadis.2024.167172. Online ahead of print.ABSTRACTThe skeletal muscle is a metabolically heterogeneous tissue that plays a key role in maintaining whole-body glucose homeostasis. It is well known that muscle insulin resistance (IR) precedes the development of type 2 diabetes. There is a consensus that the accumulation of specific lipid species in the tissue can drive IR. However, the role of the mitochondrial fatty-acid β-oxidation in IR and, consequently, in the control of glucose uptake remains paradoxical: interventions that either inhibit or activa...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Marcel A Vieira-Lara Barbara M Bakker Source Type: research
Genetic variants of ANRIL and coronary artery disease: Insights from a Turkish study population
CONCLUSIONS: In conclusion, selected ANRIL polymorphisms were associated with CAD presence/severity and CAD risk factors, T2DM, and hypertension. Notably, this study, the largest sample-sized study examining the effects of selected polymorphisms on CAD and its risk factors among Turkish individuals, supported the findings of previous studies conducted on different ethnicities.PMID:38631653 | DOI:10.1016/j.gene.2024.148475 (Source: Gene)
Source: Gene - April 17, 2024 Category: Genetics & Stem Cells Authors: Aybike Sena Ozuynuk-Ertugrul Cemre Buse Kirsan Aycan Fahri Erkan Berkay Ekici Evrim Komurcu-Bayrak Neslihan Coban Source Type: research
A Comprehensive Review on GLP-1 Signaling Pathways in the Management of Diabetes Mellitus - Focus on the Potential Role of GLP-1 Receptors Agonists and Selenium Among Various Organ Systems
Curr Diabetes Rev. 2024 Apr 16. doi: 10.2174/0115733998287178240403055901. Online ahead of print.ABSTRACTDiabetes Mellitus develops when the body becomes unable to fuel its cells with glucose, which results in the accumulation of sugar excess in the bloodstream. Because it has diverse pathophysiological impacts on the body, diabetes mellitus represents a significant issue of concern in an attempt to find suitable treatment modalities and medications for afflicted diabetic patients. Glucagon-like peptide 1 (GLP-1) plays a pivotal role in the incretin effect, emerging as a prospective treatment for diabetes mellitus and a pr...
Source: Current Diabetes Reviews - April 17, 2024 Category: Endocrinology Authors: Ghinwa Barakat Ghaith Assi Hussein Khalil Sami El Khatib Source Type: research
Non-linear associations of atherogenic index of plasma with prediabetes and type 2 diabetes mellitus among Chinese adults aged 45 years and above: a cross-sectional study from CHARLS
CONCLUSIONS: This study demonstrated non-linear positive associations of AIP with the risk of prediabetes and T2DM among participants ≥ 45 years of age in China.PMID:38628590 | PMC:PMC11018972 | DOI:10.3389/fendo.2024.1360874 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Luqing Jiang Lei Li Zichen Xu Yu Tang Ying Zhai Xia Fu Daoqin Liu Qiwen Wu Source Type: research
Genetic variants of ANRIL and coronary artery disease: Insights from a Turkish study population
CONCLUSIONS: In conclusion, selected ANRIL polymorphisms were associated with CAD presence/severity and CAD risk factors, T2DM, and hypertension. Notably, this study, the largest sample-sized study examining the effects of selected polymorphisms on CAD and its risk factors among Turkish individuals, supported the findings of previous studies conducted on different ethnicities.PMID:38631653 | DOI:10.1016/j.gene.2024.148475 (Source: Gene)
Source: Gene - April 17, 2024 Category: Genetics & Stem Cells Authors: Aybike Sena Ozuynuk-Ertugrul Cemre Buse Kirsan Aycan Fahri Erkan Berkay Ekici Evrim Komurcu-Bayrak Neslihan Coban Source Type: research
Decoding triancestral origins, archaic introgression, and natural selection in the Japanese population by whole-genome sequencing
Sci Adv. 2024 Apr 19;10(16):eadi8419. doi: 10.1126/sciadv.adi8419. Epub 2024 Apr 17.ABSTRACTWe generated Japanese Encyclopedia of Whole-Genome/Exome Sequencing Library (JEWEL), a high-depth whole-genome sequencing dataset comprising 3256 individuals from across Japan. Analysis of JEWEL revealed genetic characteristics of the Japanese population that were not discernible using microarray data. First, rare variant-based analysis revealed an unprecedented fine-scale genetic structure. Together with population genetics analysis, the present-day Japanese can be decomposed into three ancestral components. Second, we identified u...
Source: Adv Data - April 17, 2024 Category: Epidemiology Authors: Xiaoxi Liu Satoshi Koyama Kohei Tomizuka Sadaaki Takata Yuki Ishikawa Shuji Ito Shunichi Kosugi Kunihiko Suzuki Keiko Hikino Masaru Koido Yoshinao Koike Momoko Horikoshi Takashi Gakuhari Shiro Ikegawa Kochi Matsuda Yukihide Momozawa Kaoru Ito Yoichiro Kam Source Type: research
Vasculitis and infectious risk in a patient with type 2 diabetes mellitus: A case report
Exp Ther Med. 2024 Mar 27;27(5):234. doi: 10.3892/etm.2024.12522. eCollection 2024 May.ABSTRACTThe connection between vasculitis and infection is complex. The present study described a typical situation for a patient with unbalanced type 2 diabetes and chronic complications, in which a lack of adherence to the protection and care measures ultimately led to the appearance of some of the worst consequences of the condition, namely, ulceration, gangrene and amputation. In the context of an unstable condition with significant metabolic imbalance there was an impaired response to infections in the present patient, and the amput...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Roxana M ădălina Mitroi Maria Magdalena Ro șu Diana Clenciu Vlad P ădureanu Adina Mitrea Maria Andreea Grigore Emilia Roxana Mazilu Dumitru R ădulescu Ionela Mihaela Vladu Source Type: research
Cyclopeptide alkaloids from the Greek shrub < em > Paliurus spina < /em > - < em > christi < /em > and their < em > in silico < /em > binding affinity to Dipeptidyl Peptidase IV
Nat Prod Res. 2024 Apr 17:1-11. doi: 10.1080/14786419.2024.2340755. Online ahead of print.ABSTRACTA new cyclopeptide alkaloid, spinachristene A (1), along with two previously described, sanjoinenine (2) and oxyphylline C (3), were isolated from the fruits of Paliurus spina-christi Mill. All three metabolites are being isolated for the first time from the genus Paliurus. A model for the in silico binding affinity of compounds 1-3 to Dipeptidyl Peptidase IV (DPP4), which is related to type 2 diabetes (T2D), was developed. According to our model, compounds 1-3 were ranked in positions 9/12, 11/12 and 8/12, respectively and ar...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Vaios Amountzias Dennis Abatis Antonios Drakopoulos Grigoris Zoidis Nektarios Aligiannis Source Type: research
