Angiotensin-converting enzyme I/D gene polymorphism and risk of type 2 diabetes mellitus in Iranian individuals
This study aimed to examine the relationship between type 2 diabetes mellitus (T2DM) and renin-angiotensin system gene polymorphisms in the Iranian population. Additionally, we performed a straightforward meta-analysis of the present articles to better understand this role. A total of 100 Iranian individuals, 50 patients with T2DM, and 50 age-matched healthy individuals were included in this study. DNA was extracted using the salting-out approach, polymerase chain reaction was used to amplify the angiotensin-converting enzyme (ACE) gene, electrophoresis techniques were used, and genotyping was performed. We also searched P...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 23, 2024 Category: Biochemistry Authors: Mohammad Amin Momeni-Moghaddam Hanieh Chahkandi Narges Amini Beidokhti Marziye Rahmani Davoud Salarbashi Milad Khorasani Source Type: research
Probing benzenesulfonamide-thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase II
Eur J Med Chem. 2024 Apr 20;271:116434. doi: 10.1016/j.ejmech.2024.116434. Online ahead of print.ABSTRACTDiabetes mellitus is a chronic metabolic disorder characterized by improper expression/function of a number of key enzymes that can be regarded as targets for anti-diabetic drug design. Herein, we report the design, synthesis, and biological assessment of two series of thiazolidinone-based sulfonamides 4a-l and 5a-c as multitarget directed ligands (MTDLs) with potential anti-diabetic activity through targeting the enzymes: α-glucosidase and human carbonic anhydrase (hCA) II. The synthesized sulfonamides were evaluated ...
Source: European Journal of Medicinal Chemistry - April 23, 2024 Category: Chemistry Authors: Mona A Gamal Samar H Fahim Simone Giovannuzzi Marwa A Fouad Alessandro Bonardi Paola Gratteri Claudiu T Supuran Ghaneya S Hassan Source Type: research
Primary Technology Enhanced Care Home HbA1c Testing (PTEC HAT) programme: a feasibility pilot study in Singapore
CONCLUSION: Our findings support home HbA1c testing by patients coupled with telemonitoring and teleconsultations. Following are practical recommendations for the implementation scaling phase: offering PTEC HAT Programme to suitable patients who are self-motivated and have adequate digital literacy, provision of adequate educational and training support, sending reminders and exploring enabling manual submission of HbA1c readings considering Bluetooth-related challenges.PMID:38654201 | PMC:PMC11040893 | DOI:10.1186/s12875-024-02373-w (Source: Primary Care)
Source: Primary Care - April 23, 2024 Category: Primary Care Authors: Shilpa Tyagi Gerald Choon-Huat Koh Eng Sing Lee Kah Pieng Ong Roy Heng Lian Hwa Er Evonne Oh Valerie Teo David Wei Liang Ng Source Type: research
The association between depressive symptoms and executive function in type 1 diabetes population: A scoping review
CONCLUSION: In summary, the seven studies in this review suggest that individuals with T1DM who report depressive symptoms are at a higher risk of poor executive function; a clear association between depressive symptoms and executive function in individuals with T1DM remains inconclusive. There is a need to explore this relationship in the future.PMID:38653620 | DOI:10.1016/j.pcd.2024.04.001 (Source: Primary Care)
Source: Primary Care - April 23, 2024 Category: Primary Care Authors: Chawisa Dandamrongrak Kaitlyn Rechenberg Jumpee Granger Ayesha Johnson Kailei Yan Jennifer Kue Source Type: research
Effect of empagliflozin in peripheral diabetic neuropathy of patients with type 2 diabetes mellitus
CONCLUSIONS: Empagliflozin may be a promising neuroprotective and therapeutic agent for diabetic peripheral neuropathy. Trial registration Identifier: NCT05977465.PMID:38653618 | DOI:10.1016/j.medcli.2024.01.027 (Source: Medicina Clinica)
Source: Medicina Clinica - April 23, 2024 Category: General Medicine Authors: Sahar Mohamed El-Haggar Yasser Mostafa Hafez Amira Mohamed El Sharkawy Maha Khalifa Source Type: research
No effect of liraglutide on high density lipoprotein apolipoprotein AI kinetics in patients with type 2 diabetes
CONCLUSION: Six months of treatment with 1.2 mg/day of liraglutide had no effect on the kinetics of HDL apoAI in patients with T2D. The lack of decrease in triglyceride content in HDL related to an only moderate decrease in triglyceridemia, probably greatly explains these results. Insufficient improvement of insulin sensitivity and adiponectinemia may also be implied.PMID:38653365 | DOI:10.1016/j.diabet.2024.101535 (Source: Diabetes and Metabolism)
Source: Diabetes and Metabolism - April 23, 2024 Category: Endocrinology Authors: Laurence Duvillard Jean-Paul Pais de Barros Alexia Rouland Isabelle Simoneau Damien Denimal Benjamin Bouillet Jean-Michel Petit Bruno Verg ès Source Type: research
Dipeptidyl peptidase 4 inhibitors vs. metformin for new-onset dementia: a propensity score-matched cohort study
CONCLUSION: In this real-world study, we found that DPP4 inhibitors presented an association with a lower risk of dementia in individuals with type 2 diabetes than metformin, particularly in older people and those without diabetes-related comorbidities.PMID:38652239 | DOI:10.1210/clinem/dgae281 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Siyang Liu Heng Wan Sheng Nie Huanyi Cao Lan Liu Hua Liang Hong Xu Bicheng Liu Chunbo Chen Huafeng Liu Qiongqiong Yang Hua Li Yaozhong Kong Guisen Li Qijun Wan Yan Zha Ying Hu Gang Xu Yongjun Shi Yilun Zhou Guobin Su Ying Tang Mengchun Gong Aixin Guo Jian Source Type: research
Efficacy and Safety of Alogliptin-Pioglitazone Combination for Type 2 Diabetes Mellitus Poorly Controlled with Metformin: A Multicenter, Double-Blind Randomized Trial
CONCLUSION: Early combination triple therapy showed better efficacy and durability than the single add-on (dual) therapy. Therefore, combination therapy with metformin, alogliptin, and pioglitazone is a valuable early treatment option for T2DM poorly controlled with metformin monotherapy.PMID:38650099 | DOI:10.4093/dmj.2023.0259 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - April 23, 2024 Category: Endocrinology Authors: Ji-Yeon Park Joonyub Lee Yoon-Hee Choi Kyung Wan Min Kyung Ah Han Kyu Jeung Ahn Soo Lim Young-Hyun Kim Chul Woo Ahn Kyung Mook Choi Kun-Ho Yoon Practical Evidence of Antidiabetic Combination Therapy in Korea (PEAK) study investigators Source Type: research
The β3-AR agonist BRL37344 ameliorates the main symptoms of X-linked nephrogenic diabetes insipidus in the mouse model of the disease
J Cell Mol Med. 2024 Apr;28(8):e18301. doi: 10.1111/jcmm.18301.ABSTRACTX-linked nephrogenic diabetes insipidus (X-NDI) is a rare congenital disease caused by inactivating mutations of the vasopressin type-2 receptor (AVPR2), characterized by impaired renal concentrating ability, dramatic polyuria, polydipsia and risk of dehydration. The disease, which still lacks a cure, could benefit from the pharmacologic stimulation of other GPCRs, activating the cAMP-intracellular pathway in the kidney cells expressing the AVPR2. On the basis of our previous studies, we here hypothesized that the β3-adrenergic receptor could be such a...
Source: J Cell Mol Med - April 23, 2024 Category: Molecular Biology Authors: Serena Milano Ilenia Saponara Andrea Gerbino Monica Carmosino Maria Svelto Giuseppe Procino Source Type: research
The β3-AR agonist BRL37344 ameliorates the main symptoms of X-linked nephrogenic diabetes insipidus in the mouse model of the disease
J Cell Mol Med. 2024 Apr;28(8):e18301. doi: 10.1111/jcmm.18301.ABSTRACTX-linked nephrogenic diabetes insipidus (X-NDI) is a rare congenital disease caused by inactivating mutations of the vasopressin type-2 receptor (AVPR2), characterized by impaired renal concentrating ability, dramatic polyuria, polydipsia and risk of dehydration. The disease, which still lacks a cure, could benefit from the pharmacologic stimulation of other GPCRs, activating the cAMP-intracellular pathway in the kidney cells expressing the AVPR2. On the basis of our previous studies, we here hypothesized that the β3-adrenergic receptor could be such a...
Source: Molecular Medicine - April 23, 2024 Category: Molecular Biology Authors: Serena Milano Ilenia Saponara Andrea Gerbino Monica Carmosino Maria Svelto Giuseppe Procino Source Type: research
Angiotensin-converting enzyme I/D gene polymorphism and risk of type 2 diabetes mellitus in Iranian individuals
This study aimed to examine the relationship between type 2 diabetes mellitus (T2DM) and renin-angiotensin system gene polymorphisms in the Iranian population. Additionally, we performed a straightforward meta-analysis of the present articles to better understand this role. A total of 100 Iranian individuals, 50 patients with T2DM, and 50 age-matched healthy individuals were included in this study. DNA was extracted using the salting-out approach, polymerase chain reaction was used to amplify the angiotensin-converting enzyme (ACE) gene, electrophoresis techniques were used, and genotyping was performed. We also searched P...
Source: Nucleosides, Nucleotides and Nucleic Acids - April 23, 2024 Category: Biochemistry Authors: Mohammad Amin Momeni-Moghaddam Hanieh Chahkandi Narges Amini Beidokhti Marziye Rahmani Davoud Salarbashi Milad Khorasani Source Type: research
Probing benzenesulfonamide-thiazolidinone hybrids as multitarget directed ligands for efficient control of type 2 diabetes mellitus through targeting the enzymes: α-glucosidase and carbonic anhydrase II
Eur J Med Chem. 2024 Apr 20;271:116434. doi: 10.1016/j.ejmech.2024.116434. Online ahead of print.ABSTRACTDiabetes mellitus is a chronic metabolic disorder characterized by improper expression/function of a number of key enzymes that can be regarded as targets for anti-diabetic drug design. Herein, we report the design, synthesis, and biological assessment of two series of thiazolidinone-based sulfonamides 4a-l and 5a-c as multitarget directed ligands (MTDLs) with potential anti-diabetic activity through targeting the enzymes: α-glucosidase and human carbonic anhydrase (hCA) II. The synthesized sulfonamides were evaluated ...
Source: European Journal of Medicinal Chemistry - April 23, 2024 Category: Chemistry Authors: Mona A Gamal Samar H Fahim Simone Giovannuzzi Marwa A Fouad Alessandro Bonardi Paola Gratteri Claudiu T Supuran Ghaneya S Hassan Source Type: research
Primary Technology Enhanced Care Home HbA1c Testing (PTEC HAT) programme: a feasibility pilot study in Singapore
CONCLUSION: Our findings support home HbA1c testing by patients coupled with telemonitoring and teleconsultations. Following are practical recommendations for the implementation scaling phase: offering PTEC HAT Programme to suitable patients who are self-motivated and have adequate digital literacy, provision of adequate educational and training support, sending reminders and exploring enabling manual submission of HbA1c readings considering Bluetooth-related challenges.PMID:38654201 | DOI:10.1186/s12875-024-02373-w (Source: Primary Care)
Source: Primary Care - April 23, 2024 Category: Primary Care Authors: Shilpa Tyagi Gerald Choon-Huat Koh Eng Sing Lee Kah Pieng Ong Roy Heng Lian Hwa Er Evonne Oh Valerie Teo David Wei Liang Ng Source Type: research
The association between depressive symptoms and executive function in type 1 diabetes population: A scoping review
CONCLUSION: In summary, the seven studies in this review suggest that individuals with T1DM who report depressive symptoms are at a higher risk of poor executive function; a clear association between depressive symptoms and executive function in individuals with T1DM remains inconclusive. There is a need to explore this relationship in the future.PMID:38653620 | DOI:10.1016/j.pcd.2024.04.001 (Source: Primary Care)
Source: Primary Care - April 23, 2024 Category: Primary Care Authors: Chawisa Dandamrongrak Kaitlyn Rechenberg Jumpee Granger Ayesha Johnson Kailei Yan Jennifer Kue Source Type: research
Dipeptidyl peptidase 4 inhibitors vs. metformin for new-onset dementia: a propensity score-matched cohort study
CONCLUSION: In this real-world study, we found that DPP4 inhibitors presented an association with a lower risk of dementia in individuals with type 2 diabetes than metformin, particularly in older people and those without diabetes-related comorbidities.PMID:38652239 | DOI:10.1210/clinem/dgae281 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 23, 2024 Category: Endocrinology Authors: Siyang Liu Heng Wan Sheng Nie Huanyi Cao Lan Liu Hua Liang Hong Xu Bicheng Liu Chunbo Chen Huafeng Liu Qiongqiong Yang Hua Li Yaozhong Kong Guisen Li Qijun Wan Yan Zha Ying Hu Gang Xu Yongjun Shi Yilun Zhou Guobin Su Ying Tang Mengchun Gong Aixin Guo Jian Source Type: research
