Kidney and Cardiovascular Effectiveness of Empagliflozin Compared to Dipeptidyl Peptidase-4 Inhibitors in Patients with Type 2 Diabetes
Placebo-controlled trials of sodium-glucose cotransporter-2 inhibitors (SGLT2i) demonstrate kidney and cardiovascular benefits for people with type 2 diabetes (T2D) and chronic kidney disease (CKD). We used real-world data to compare the kidney and cardiovascular effectiveness of empagliflozin to dipeptidyl peptidase-4 inhibitors (DPP4i), a commonly prescribed antiglycemic medication, in a diverse population with and without CKD. Using electronic health record data from 20 large US health systems, we leveraged propensity overlap weighting to compare outcomes for empagliflozin and DPP4i initiators with T2D between 2016 and ...
Source: The American Journal of Cardiology - April 17, 2024 Category: Cardiology Authors: Daniel Edmonston, Hillary Mulder, Elizabeth Lydon, Karen Chiswell, Zachary Lampron, Christina Shay, Keith Marsolo, W. Schuyler Jones, Javed Butler, Raj C. Shah, Alanna M. Chamberlain, Daniel E. Ford, Howard S. Gordon, Wenke Hwang, Alexander Chang, Ajaykum Source Type: research
Pneumoperitoneum, pneumoretroperitoneum and pneumomediastinum: rare complications of perforation peritonitis: a case report
ConclusionsThis case report highlights the clinical novelty of gas extravasation complications in perforated diverticulitis. The unique triad of pneumoperitoneum, pneumoretroperitoneum, and pneumomediastinum in a 74-year-old female underscores the diagnostic challenges and the importance of advanced imaging techniques. The successful collaboration between radiologists and surgeons facilitated a timely and accurate diagnosis, enabling a minimally invasive surgical approach. This case contributes to the understanding of atypical presentations of diverticulitis and emphasizes the significance of interdisciplinary teamwork in ...
Source: Journal of Medical Case Reports - April 17, 2024 Category: General Medicine Source Type: research
Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications
J Diet Suppl. 2024 Apr 15:1-32. doi: 10.1080/19390211.2024.2340509. Online ahead of print.ABSTRACTDiabetes is a metabolic disorder whose prevalence has become a worrying condition in recent decades. Chronic diabetes can result in serious health conditions such as impaired kidney function, stroke, blindness, and myocardial infarction. Despite a variety of currently available treatments, cases of diabetes and its complications are on the rise. This review article provides a comprehensive account of the ameliorative effect of prebiotics and probiotics individually or in combination i.e. synbiotics on health complications indu...
Source: Journal of Dietary Supplements - April 16, 2024 Category: Nutrition Authors: Kalpana Baghel Aamir Khan Naveen Kango Source Type: research
Methods to predict heart failure in diabetes patients
Expert Rev Endocrinol Metab. 2024 Apr 15:1-16. doi: 10.1080/17446651.2024.2342812. Online ahead of print.ABSTRACTINTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the leading causes of cardiovascular disease and powerful predictor for new-onset heart failure (HF).AREAS COVERED: We focus on the relevant literature covering evidence of risk stratification based on imaging predictors and circulating biomarkers to optimize approaches to preventing HF in DM patients.EXPERT OPINION: Multiple diagnostic algorithms based on echocardiographic parameters of cardiac remodeling including global longitudinal strain/strain rate ar...
Source: Expert Review of Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Alexander E Berezin Tetiana A Berezina Uta C Hoppe Michael Lichtenauer Alexander A Berezin Source Type: research
Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications
J Diet Suppl. 2024 Apr 15:1-32. doi: 10.1080/19390211.2024.2340509. Online ahead of print.ABSTRACTDiabetes is a metabolic disorder whose prevalence has become a worrying condition in recent decades. Chronic diabetes can result in serious health conditions such as impaired kidney function, stroke, blindness, and myocardial infarction. Despite a variety of currently available treatments, cases of diabetes and its complications are on the rise. This review article provides a comprehensive account of the ameliorative effect of prebiotics and probiotics individually or in combination i.e. synbiotics on health complications indu...
Source: Journal of Dietary Supplements - April 16, 2024 Category: Nutrition Authors: Kalpana Baghel Aamir Khan Naveen Kango Source Type: research
Methods to predict heart failure in diabetes patients
Expert Rev Endocrinol Metab. 2024 Apr 15:1-16. doi: 10.1080/17446651.2024.2342812. Online ahead of print.ABSTRACTINTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the leading causes of cardiovascular disease and powerful predictor for new-onset heart failure (HF).AREAS COVERED: We focus on the relevant literature covering evidence of risk stratification based on imaging predictors and circulating biomarkers to optimize approaches to preventing HF in DM patients.EXPERT OPINION: Multiple diagnostic algorithms based on echocardiographic parameters of cardiac remodeling including global longitudinal strain/strain rate ar...
Source: Expert Review of Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Alexander E Berezin Tetiana A Berezina Uta C Hoppe Michael Lichtenauer Alexander A Berezin Source Type: research
Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications
J Diet Suppl. 2024 Apr 15:1-32. doi: 10.1080/19390211.2024.2340509. Online ahead of print.ABSTRACTDiabetes is a metabolic disorder whose prevalence has become a worrying condition in recent decades. Chronic diabetes can result in serious health conditions such as impaired kidney function, stroke, blindness, and myocardial infarction. Despite a variety of currently available treatments, cases of diabetes and its complications are on the rise. This review article provides a comprehensive account of the ameliorative effect of prebiotics and probiotics individually or in combination i.e. synbiotics on health complications indu...
Source: Journal of Dietary Supplements - April 16, 2024 Category: Nutrition Authors: Kalpana Baghel Aamir Khan Naveen Kango Source Type: research
Methods to predict heart failure in diabetes patients
Expert Rev Endocrinol Metab. 2024 Apr 15:1-16. doi: 10.1080/17446651.2024.2342812. Online ahead of print.ABSTRACTINTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the leading causes of cardiovascular disease and powerful predictor for new-onset heart failure (HF).AREAS COVERED: We focus on the relevant literature covering evidence of risk stratification based on imaging predictors and circulating biomarkers to optimize approaches to preventing HF in DM patients.EXPERT OPINION: Multiple diagnostic algorithms based on echocardiographic parameters of cardiac remodeling including global longitudinal strain/strain rate ar...
Source: Expert Review of Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Alexander E Berezin Tetiana A Berezina Uta C Hoppe Michael Lichtenauer Alexander A Berezin Source Type: research
The effect of EGCG/tyrosol-loaded chitosan/lecithin nanoparticles on hyperglycemia and hepatic function in streptozotocin-induced diabetic mice
In conclusion, the EGCG/tyrosol-loaded C/L NPs reduced hyperglycemia, oxidative stress, and inflammation in diabetic mice. These findings suggest that EGCG/tyrosol-loaded C/L NPs could be a promising therapeutic option for type 2 diabetes management.PMID:38626839 | DOI:10.1016/j.ijbiomac.2024.131496 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Ali Es-Haghi Mozhgan Soltani Masoud Homayouni Tabrizi Maryam Karimi Noghondar Nilofar Khatamian Niloofar Barati Naeeni Matin Kharaghani Source Type: research
Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications
J Diet Suppl. 2024 Apr 15:1-32. doi: 10.1080/19390211.2024.2340509. Online ahead of print.ABSTRACTDiabetes is a metabolic disorder whose prevalence has become a worrying condition in recent decades. Chronic diabetes can result in serious health conditions such as impaired kidney function, stroke, blindness, and myocardial infarction. Despite a variety of currently available treatments, cases of diabetes and its complications are on the rise. This review article provides a comprehensive account of the ameliorative effect of prebiotics and probiotics individually or in combination i.e. synbiotics on health complications indu...
Source: Journal of Dietary Supplements - April 16, 2024 Category: Nutrition Authors: Kalpana Baghel Aamir Khan Naveen Kango Source Type: research
Plasma proteomics of diabetic kidney disease among Asians with younger-onset type 2 diabetes
CONCLUSION: Large-scale proteomic analysis identified novel proteomic biomarkers for DKD progression in YT2D. Genetic evidence suggest a causal role of plasma angiogenin in DKD progression.PMID:38626182 | DOI:10.1210/clinem/dgae266 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Resham Lal Gurung Huili Zheng Hiromi Wai Ling Koh M Yiamunaa Jian-Jun Liu Sylvia Liu Clara Chan Keven Ang Clara Si Hua Tan Radoslaw Mikolaj Sobota Tavintharan Subramaniam Chee Fang Sum Su Chi Lim Source Type: research
IRE1 α regulates macrophage polarization in type 2 diabetic periodontitis through promoting endoplasmic reticulum stress
CONCLUSIONS: These findings suggest that inhibiting IRE1α can modulate macrophage polarization and alleviate ligature-induced diabetic periodontitis via the MAPK signaling pathway. This unveils a novel mechanism, offering a scientific foundation for the treatment of experimental diabetic periodontitis.PMID:38626546 | DOI:10.1016/j.intimp.2024.112056 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Yang Zhang Yanan Zhang Miao Lu Xulei Yuan Guangyue Li Ling Xu Tingwei Zhang Jinlin Song Source Type: research
Therapy combining glucagon-like peptide-1 receptor agonist with sodium-glucose cotransporter 2 inhibitor suppresses atherosclerosis in diabetic ApoE-deficient mice
Conclusions Our data suggest that combination therapy with liraglutide and ipragliflozin may be an efficient regimen for preventing the development of atherosclerosis in diabetic ApoE-deficient mice.PMID:38626913 | DOI:10.1055/a-2307-8036 (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Masahiro Takubo Kentaro Watanabe Hitoki Saito Genta Kohno Hisamitsu Ishihara Source Type: research
Comprehensive safety profile of dipeptidyl peptidase-4 inhibitors: a post-marketing study based on FAERS database using signal detection algorithms
CONCLUSION: Several significant disproportionality signals were observed with DPP-4 inhibitors. However, clinicians have to consider the comorbidities and concomitant drugs while prescribing these drugs.PMID:38626310 | DOI:10.1080/14740338.2024.2343015 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - April 16, 2024 Category: Drugs & Pharmacology Authors: Dipika Bansal Beema T Yoosuf Muhammed Favas Kt Pinaki Dutta Source Type: research
