IRE1 α regulates macrophage polarization in type 2 diabetic periodontitis through promoting endoplasmic reticulum stress

CONCLUSIONS: These findings suggest that inhibiting IRE1α can modulate macrophage polarization and alleviate ligature-induced diabetic periodontitis via the MAPK signaling pathway. This unveils a novel mechanism, offering a scientific foundation for the treatment of experimental diabetic periodontitis.PMID:38626546 | DOI:10.1016/j.intimp.2024.112056

Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Yang Zhang Yanan Zhang Miao Lu Xulei Yuan Guangyue Li Ling Xu Tingwei Zhang Jinlin Song Source Type: research