The effect of EGCG/tyrosol-loaded chitosan/lecithin nanoparticles on hyperglycemia and hepatic function in streptozotocin-induced diabetic mice
In conclusion, the EGCG/tyrosol-loaded C/L NPs reduced hyperglycemia, oxidative stress, and inflammation in diabetic mice. These findings suggest that EGCG/tyrosol-loaded C/L NPs could be a promising therapeutic option for type 2 diabetes management.PMID:38626839 | DOI:10.1016/j.ijbiomac.2024.131496 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Ali Es-Haghi Mozhgan Soltani Masoud Homayouni Tabrizi Maryam Karimi Noghondar Nilofar Khatamian Niloofar Barati Naeeni Matin Kharaghani Source Type: research
Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications
J Diet Suppl. 2024 Apr 15:1-32. doi: 10.1080/19390211.2024.2340509. Online ahead of print.ABSTRACTDiabetes is a metabolic disorder whose prevalence has become a worrying condition in recent decades. Chronic diabetes can result in serious health conditions such as impaired kidney function, stroke, blindness, and myocardial infarction. Despite a variety of currently available treatments, cases of diabetes and its complications are on the rise. This review article provides a comprehensive account of the ameliorative effect of prebiotics and probiotics individually or in combination i.e. synbiotics on health complications indu...
Source: Journal of Dietary Supplements - April 16, 2024 Category: Nutrition Authors: Kalpana Baghel Aamir Khan Naveen Kango Source Type: research
Plasma proteomics of diabetic kidney disease among Asians with younger-onset type 2 diabetes
CONCLUSION: Large-scale proteomic analysis identified novel proteomic biomarkers for DKD progression in YT2D. Genetic evidence suggest a causal role of plasma angiogenin in DKD progression.PMID:38626182 | DOI:10.1210/clinem/dgae266 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 16, 2024 Category: Endocrinology Authors: Resham Lal Gurung Huili Zheng Hiromi Wai Ling Koh M Yiamunaa Jian-Jun Liu Sylvia Liu Clara Chan Keven Ang Clara Si Hua Tan Radoslaw Mikolaj Sobota Tavintharan Subramaniam Chee Fang Sum Su Chi Lim Source Type: research
IRE1 α regulates macrophage polarization in type 2 diabetic periodontitis through promoting endoplasmic reticulum stress
CONCLUSIONS: These findings suggest that inhibiting IRE1α can modulate macrophage polarization and alleviate ligature-induced diabetic periodontitis via the MAPK signaling pathway. This unveils a novel mechanism, offering a scientific foundation for the treatment of experimental diabetic periodontitis.PMID:38626546 | DOI:10.1016/j.intimp.2024.112056 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Yang Zhang Yanan Zhang Miao Lu Xulei Yuan Guangyue Li Ling Xu Tingwei Zhang Jinlin Song Source Type: research
Therapy combining glucagon-like peptide-1 receptor agonist with sodium-glucose cotransporter 2 inhibitor suppresses atherosclerosis in diabetic ApoE-deficient mice
Conclusions Our data suggest that combination therapy with liraglutide and ipragliflozin may be an efficient regimen for preventing the development of atherosclerosis in diabetic ApoE-deficient mice.PMID:38626913 | DOI:10.1055/a-2307-8036 (Source: Atherosclerosis)
Source: Atherosclerosis - April 16, 2024 Category: Cardiology Authors: Masahiro Takubo Kentaro Watanabe Hitoki Saito Genta Kohno Hisamitsu Ishihara Source Type: research
