Redox Status as a Key Driver of Healthy Pancreatic Beta-Cells
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTRedox status plays a multifaceted role in the intricate physiology and pathology of pancreatic beta-cells, the pivotal regulators of glucose homeostasis through insulin secretion. They are highly responsive to changes in metabolic cues where reactive oxygen species are part of it, all arising from nutritional intake. These molecules not only serve as crucial signaling intermediates for insulin secretion but also participate in the nuanced heterogeneity observed within the beta-cell population. A central aspect of beta-cell redox biology revolves around the localized p...
Source: Physiological Research - April 22, 2024 Category: Physiology Authors: B Holendov á Š Benáková M K řivonosková L Plecit á-Hlavatá Source Type: research
Management of Type 2 Diabetes Mellitus With Noninsulin Pharmacotherapy
Am Fam Physician. 2024 Apr;109(4):333-342.ABSTRACTType 2 diabetes mellitus is a chronic disease that is increasing in global prevalence. An individualized approach to pharmacotherapy should consider costs, benefits beyond glucose control, and adverse events. Metformin is the first-line therapy due to its low cost and effectiveness. Sulfonylureas and thiazolidinediones are additional low-cost oral hypoglycemic classes available in the United States; however, evidence shows variability in weight gain and hypoglycemia. Thiazolidinediones increase fluid retention and are not recommended in patients with New York Heart Associat...
Source: American Family Physician - April 22, 2024 Category: Primary Care Authors: Elizabeth M Vaughan Zuleica M Santiago-Delgado Source Type: research
Effects of an environmentally relevant mixture of organochlorine pesticide compounds on adipogenesis and adipocyte function in an immortalized human adipocyte model
Toxicol In Vitro. 2024 Apr 20:105831. doi: 10.1016/j.tiv.2024.105831. Online ahead of print.ABSTRACTExposure to persistent organic pollutants (POPs), including organochlorine (OC) pesticide POPs, has been associated with the increased prevalence of obesity and type 2 diabetes. However, the underlying mechanisms through which exposure to these compounds may promote obesity and metabolic dysfunction remain an area of active investigation. To this end, the concentration dependent effects of an environmentally relevant mixture of OC pesticide POPs on adipocyte function was explored utilizing a translationally relevant immortal...
Source: Toxicology in Vitro - April 22, 2024 Category: Toxicology Authors: George E Howell Darian Young Source Type: research
Myopia and Rate of Peripapillary Retinal Nerve Fiber Layer Thickness in Diabetic Patients Without Retinopathy: A 2-Year Longitudinal Study
CONCLUSIONS: The diabetes group showed a faster rate of average pRNFL thickness reduction compared to healthy controls, regardless of the presence of myopia. The average pRNFL thickness decreased more rapidly when diabetes and myopia were present simultaneously than in the individual diabetes or myopia group. Both diabetes and myopia were associated with accelerated pRNFL loss.PMID:38647053 | DOI:10.1080/02713683.2024.2327087 (Source: Current Eye Research)
Source: Current Eye Research - April 22, 2024 Category: Opthalmology Authors: Yi Wu Kang Ning Mingguang He Wenyong Huang Wei Wang Source Type: research
Factors associated with development of retinopathy in patients with type 2 diabetes mellitus at onset and within three years after diagnosis
CONCLUSION: These findings indicate that the risk of developing diabetes retinopathy is present early on at onset and within the first three years of diabetes diagnosis. This highlights the importance of promptly regulating glucose- and blood-pressure levels and follow up kidney dysfunction to mitigate the risk of diabetes retinopathy.PMID:38647202 | DOI:10.1080/02813432.2024.2329215 (Source: Primary Care)
Source: Primary Care - April 22, 2024 Category: Primary Care Authors: Kajsa Andersson Anders Halling Bj örn Agvall Source Type: research
Understanding suboptimal insulin use in type 1 and 2 diabetes: a cross-sectional survey of healthcare providers who treat people with diabetes
CONCLUSIONS: Other studies have shown that PwD frequently experience suboptimal insulin dosing. Conversely, results from this study showed that HCPs believe suboptimal insulin dosing among PwD is limited in frequency. While no direct comparisons were made in this study, this apparent discrepancy could lead to difficulties in HCPs giving PwD the best advice on optimal insulin management. Approaches such as improving the objectivity of dose measurements for both PwD and HCPs may improve associated communications and help reduce suboptimal insulin dosing, thus enhancing treatment outcomes.PMID:38649812 | DOI:10.1186/s12875-02...
Source: Primary Care - April 22, 2024 Category: Primary Care Authors: Rachel S Newson Erik Spaepen Birong Liao Julie Bower Indranil Bhattacharya Esther Artime William Polonsky Source Type: research
Characterization of central-involved diabetic macular edema using OCT and OCTA
CONCLUSIONS: CI-DME and CSME appear to represent different entities. Eyes with CI-DME show increases in abnormal retinal fluid associated with increased retinal vascular perfusion in the DCP. Eyes with CSME are apparently associated with decreased retinal vascular perfusion in the DCP and abnormal fluid in the outer retina.PMID:38644796 | DOI:10.1177/11206721241248478 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - April 22, 2024 Category: Opthalmology Authors: D ébora Reste-Ferreira Torcato Santos In ês Pereira Marques Maria Lu ísa Ribeiro Ana Rita Santos Ant ónio Cunha-Vaz Martinho Concei ção Lobo Jos é Cunha-Vaz Source Type: research
Serum testosterone levels and oxidative stress in type 1 diabetes, type 2 diabetes, and obesity
CONCLUSIONS: Increased oxidative stress in diabetes may be an important factor that decreases serum testosterone levels.PMID:38646988 | DOI:10.5603/ep.98190 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Hamit Yasar Ellidag Rahime Aslanko ç Mehmet K ök G üzin Aykal Özgür Aydın Özlem Özmen Remzi Can Çakır U ğur Doğan Source Type: research
Glycaemic control among adults with type 2 diabetes mellitus in the Gulf Cooperation Council countries: an updated review
Endokrynol Pol. 2024 Apr 22. doi: 10.5603/ep.99519. Online ahead of print.ABSTRACTType 2 diabetes mellitus (T2DM) has become a major public health concern, causing significant disability and death worldwide. Fuelled by a modern sedentary lifestyle and poor dietary practices, T2DM affects at least 10.5% of the world's population. This paper seeks to review the progress made by the Gulf Cooperation Council (GCC) countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates) in addressing T2DM, focusing on glycaemic control proportions and comparing it with the 2015 review. The results indicate no signif...
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Ahmad Ali Alrasheedi Source Type: research
Renal Function Improvement With Glucagon-Like Peptide-1 Receptor Agonist in a Patient With Type 2 Diabetes
J Med Cases. 2024 Apr;15(2-3):37-42. doi: 10.14740/jmc4189. Epub 2024 Apr 8.ABSTRACTDiabetic kidney disease (DKD) includes hypertensive nephrosclerosis, aging, obesity, and atherosclerosis-related renal diseases, in addition to classical diabetic nephropathy. Sodium-glucose co-transporter 2 inhibitors (SGLT2is) have been approved for diabetic and non-diabetic patients at risk of chronic kidney disease progression. As the main mechanism for SGLT2i-mediated improvement of renal function, the normalization of tubulo-glomerular feedback (TGF) has been proposed. Enhanced TGF and resulting glomerular hypertension are observed in...
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Hidekatsu Yanai Source Type: research
Redox Status as a Key Driver of Healthy Pancreatic Beta-Cells
Physiol Res. 2024 Apr 22. Online ahead of print.ABSTRACTRedox status plays a multifaceted role in the intricate physiology and pathology of pancreatic beta-cells, the pivotal regulators of glucose homeostasis through insulin secretion. They are highly responsive to changes in metabolic cues where reactive oxygen species are part of it, all arising from nutritional intake. These molecules not only serve as crucial signaling intermediates for insulin secretion but also participate in the nuanced heterogeneity observed within the beta-cell population. A central aspect of beta-cell redox biology revolves around the localized p...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: B Holendov á Š Benáková M K řivonosková L Plecit á-Hlavatá Source Type: research
Potential immune-related therapeutic mechanisms of multiple traditional Chinese medicines on type 2 diabetic nephropathy based on bioinformatics, network pharmacology and molecular docking
CONCLUSION: The potential hub biomarkers and immunotherapy targets associated with immune cells of T2DN comprise CXCR1, CXCR2, and FOS. Furthermore, kaempferol, quercetin, and luteolin demonstrate potential immunomodulatory effects in modulating T2DN through the regulation of CXCR1, CXCR2, and FOS expression.PMID:38648716 | DOI:10.1016/j.intimp.2024.112044 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 22, 2024 Category: Allergy & Immunology Authors: Mingzheng Han Jiale Li Yijin Wu Zhaoxin Tang Source Type: research
Correction to: Effect of Neo-Policaptil Gel Retard on Liver Fat Content and Fibrosis in Adults with Metabolic Syndrome and Type 2 Diabetes: A Non-invasive Approach to MAFLD
(Source: Diabetes Therapy)
Source: Diabetes Therapy - April 22, 2024 Category: Endocrinology Source Type: research
Factors associated with development of retinopathy in patients with type 2 diabetes mellitus at onset and within three years after diagnosis
. (Source: Scandinavian Journal of Primary Health Care)
Source: Scandinavian Journal of Primary Health Care - April 22, 2024 Category: Primary Care Authors: Kajsa AnderssonAnders HallingBj örn Agvalla Capio Husläkarna Vallda, Kungsbacka, Region Halland, Halmstad, Swedenb Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Malmö, Swedenc Department of Research a Source Type: research
