Association of Acarbose with Decreased Muscle Mass and Function in Patients with Type  2 Diabetes: A Retrospective, Cross-Sectional Study
AbstractIntroductionPrevalence of sarcopenia has increased in patients with type  2 diabetes. The influence of glucose-lowering drugs on muscles in these patients remains unclear. We aimed to investigate the association between muscle mass/function and glucose-lowering drugs.MethodsData of 1042 hospitalized patients with type  2 diabetes were included in this retrospective, cross-sectional study. All the patients had stable hypoglycemic therapy in the last 3 months, and performed bioelectrical impedance analysis, grip strength, and gait speed tests on admission.ResultsSkeletal muscle index [6.81 (95%  C...
Source: Diabetes Therapy - September 20, 2021 Category: Endocrinology Source Type: research

Satisfaction, Preference and Injection Habits of Switching to 200  Units/ml Insulin Lispro Pen from 100 Units/ml: A Patient Survey in Germany
ConclusionsSatisfaction and preference for IL200 was high in this sample of patients using IL200 for 3 –12 months. Reasons were consistent with IL200 features, explaining the better patient experience and potential resource saving transitioning from a disposable MTI-100 pen. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 20, 2021 Category: Endocrinology Source Type: research

Efficacy and Safety of Switching to Teneligliptin in Patients with Type 2 Diabetes Inadequately Controlled with Dipeptidyl Peptidase-4 Inhibitors: 52-Week Results from a Prospective Observational Study
AbstractIntroductionThe aim of this study was to assess the efficacy and safety of switching to teneligliptin from other dipeptidyl peptidase-4 (DPP-4) inhibitors in patients with type 2 diabetes mellitus (T2DM) inadequately controlled despite treatment with a stable dose of other DPP-4 inhibitors.MethodsPatients with glycosylated hemoglobin (HbA1c)  ≥ 7% despite taking DPP-4 inhibitors other than teneligliptin, with or without other antidiabetic agents, for at least 3 months were enrolled in this study. Patients on DPP-4 inhibitors administered prior to participation in this study were switched to 20...
Source: Diabetes Therapy - September 18, 2021 Category: Endocrinology Source Type: research

Immediate Glucose-Lowering Effect After the First Administration of Dulaglutide: A Retrospective, Single-Center, Observational Study
This study was a retrospective and observational study of 80 subjects with type  2 diabetes conducted in a hospitalized setting. The changes (Δ) in the blood glucose (BG) levels at six time points (6-point BG levels) from the baseline (day − 1) to the day after the first administration of 0.75 mg of dulaglutide (day 1) were evaluated. The associations of the Δ 6-point BG levels with the patients’ characteristics and laboratory data were also analyzed.ResultsSignificant reduction of the fasting BG, preprandial BG, postprandial BG, and standard deviation (SD) of the 6-poi...
Source: Diabetes Therapy - September 17, 2021 Category: Endocrinology Source Type: research

Correction to: Efficacy and Safety of Luseogliflozin in Patients with Type 2 Diabetes Complicated by Hepatic Dysfunction: A Single-Site, Single-Arm, Open-Label, Exploratory Trial
(Source: Diabetes Therapy)
Source: Diabetes Therapy - September 13, 2021 Category: Endocrinology Source Type: research

Gastrointestinal Tolerability of Once-Weekly Dulaglutide 3.0 mg and 4.5 mg: A Post Hoc Analysis of the Incidence and Prevalence of Nausea, Vomiting, and Diarrhea in AWARD-11
ConclusionsThe tolerability profiles of dulaglutide 3.0  mg and 4.5 mg were consistent with that of the 1.5-mg dose. Patients experiencing GI events were most likely to do so within 2 weeks of treatment initiation, and few patients experienced a new GI event after escalating to the 3.0-mg or 4.5-mg dose. Severe events were infrequent, and when they di d occur, no relationship with dose at time of event was observed.Supplementary file1 (MP4 33880 kb) (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 12, 2021 Category: Endocrinology Source Type: research

The Therapeutic Effects of Mild to Moderate Intensity Aerobic Exercise on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Trials
ConclusionThe current analysis showed that mild to moderate intensity aerobic exercise significantly improved glycemic control in patients with T2DM. Patients with T2DM who regularly participated in aerobic exercise activities had a better control of their disease than those who were not on a regular aerobic exercise regimen. These results lead to the recommendation that at least mild to moderate intensity aerobic exercise should be included in the treatment and management regimens of patients with T2DM. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 12, 2021 Category: Endocrinology Source Type: research

Gastrointestinal Tolerability of Once-Weekly Dulaglutide 3.0 mg and 4.5 mg: A Post Hoc Analysis of the Incidence and Prevalence of Nausea, Vomiting, and Diarrhea in AWARD-11
ConclusionsThe tolerability profiles of dulaglutide 3.0  mg and 4.5 mg were consistent with that of the 1.5-mg dose. Patients experiencing GI events were most likely to do so within 2 weeks of treatment initiation, and few patients experienced a new GI event after escalating to the 3.0-mg or 4.5-mg dose. Severe events were infrequent, and when they di d occur, no relationship with dose at time of event was observed.Supplementary file1 (MP4 33880 kb) (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 12, 2021 Category: Endocrinology Source Type: research

The Therapeutic Effects of Mild to Moderate Intensity Aerobic Exercise on Glycemic Control in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Trials
ConclusionThe current analysis showed that mild to moderate intensity aerobic exercise significantly improved glycemic control in patients with T2DM. Patients with T2DM who regularly participated in aerobic exercise activities had a better control of their disease than those who were not on a regular aerobic exercise regimen. These results lead to the recommendation that at least mild to moderate intensity aerobic exercise should be included in the treatment and management regimens of patients with T2DM. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 12, 2021 Category: Endocrinology Source Type: research

The Association Between Mean Glycated Haemoglobin or Glycaemic Variability and the Development of Retinopathy in People with Diabetes: A Retrospective Observational Cohort Study
AbstractIntroductionTo determine the association between mean glycated haemoglobin (HbA1c) or glycaemic variability and the development of diabetic retinopathy (DR) in people with diabetes.MethodsAn observational cohort study with people registered with a DR eye screening service between October 2012 and October 2017. Those who had no DR at the start of the study were followed for a maximum of 5  years. HbA1c measures were used to calculate HbA1c variability and mean HbA1c to assess any relationship between these and the risk of developing new onset DR.ResultsA total of 2511 individuals were followed up for up to 5 &n...
Source: Diabetes Therapy - September 7, 2021 Category: Endocrinology Source Type: research

Effects of Different Glucose-Lowering Measures on Maternal and Infant Outcomes in Pregnant Women with Gestational Diabetes: A Network Meta-analysis
ConclusionMetformin is a potentially superior choice for GDM treatment because it is associated with minimal incidences of multiple adverse pregnancy outcome indicators and does not lead to high values of certain adverse outcome indices. Other hypoglycemic agent or diet groups exhibit high incidences of certain adverse outcomes. Therefore, when selecting a GDM treatment strategy, the efficacies and risks of different treatment programs should be evaluated according to the scenario in hand. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 4, 2021 Category: Endocrinology Source Type: research

The Effect of Verapamil on TXNIP Gene Expression, GLP1R mRNA, FBS, HbA1c, and Lipid Profile in T2DM Patients Receiving Metformin and Sitagliptin
ConclusionVerapamil can lead to better control of T2DM by reducing TXNIP gene expression and increasing beta cell survival and, possibly, by other mechanisms.Clinical Trial RegistrationIRCT registration no.: IRCT20180417039339N1 (https://www.IRCT.ir). (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 4, 2021 Category: Endocrinology Source Type: research

Effects of Different Glucose-Lowering Measures on Maternal and Infant Outcomes in Pregnant Women with Gestational Diabetes: A Network Meta-analysis
ConclusionMetformin is a potentially superior choice for GDM treatment because it is associated with minimal incidences of multiple adverse pregnancy outcome indicators and does not lead to high values of certain adverse outcome indices. Other hypoglycemic agent or diet groups exhibit high incidences of certain adverse outcomes. Therefore, when selecting a GDM treatment strategy, the efficacies and risks of different treatment programs should be evaluated according to the scenario in hand. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 4, 2021 Category: Endocrinology Source Type: research

The Effect of Verapamil on TXNIP Gene Expression, GLP1R mRNA, FBS, HbA1c, and Lipid Profile in T2DM Patients Receiving Metformin and Sitagliptin
ConclusionVerapamil can lead to better control of T2DM by reducing TXNIP gene expression and increasing beta cell survival and, possibly, by other mechanisms.Clinical Trial RegistrationIRCT registration no.: IRCT20180417039339N1 (https://www.IRCT.ir). (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 4, 2021 Category: Endocrinology Source Type: research

Glucagon-Like Peptide  1 Receptor Agonist Usage in Type 2 Diabetes in Primary Care for the UK and Beyond: A Narrative Review
AbstractThe scientific landscape of treatments for type  2 diabetes (T2D) has changed rapidly in the last decade with newer treatments becoming available. However, a large proportion of people with T2D are not able to achieve glycaemic goals because of clinical inertia. The majority of T2D management is in primary care, where clinicians (medical, nursin g and pharmacist staff) play an important role in addressing patient needs and achieving treatment goals. However, management of T2D is challenging because of the heterogeneity of T2D and complexity of comorbidity, time constraints, guidance overload and the evolving t...
Source: Diabetes Therapy - September 1, 2021 Category: Endocrinology Source Type: research

Patient Perceptions of and Preferences Between Characteristics of Injectable Diabetes Treatments
ConclusionResults of this survey suggest that patients prioritize some attributes of injectable treatments over others. These findings may have implications for clinical practice and development of injection devices. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 1, 2021 Category: Endocrinology Source Type: research

Cost Analysis of FreeStyle Libre ® 2 System in Type 2 Diabetes Mellitus Population
Conclusion FreeStyle Libre 2 system is a potential cost-saving strategy in patients with T2DM in Spain on a basal-bolus insulin regimen. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 1, 2021 Category: Endocrinology Source Type: research

Absence of QTc Prolongation with Sodium N-(8-[2-Hydroxybenzoyl] Amino) Caprylate (SNAC), an Absorption Enhancer Co-Formulated with the GLP-1 Analogue Semaglutide for Oral Administration
ConclusionThis QT/QTc trial demonstrates that SNAC doses 12-fold higher than the 300  mg dose used in the oral formulation of semaglutide do not cause unacceptable prolongation of the QTcF interval.Trial RegistrationClinicaltrials.gov identifier: NCT02911870. (Source: Diabetes Therapy)
Source: Diabetes Therapy - September 1, 2021 Category: Endocrinology Source Type: research

Impact of Socioeconomic Factors and Gender on Refill Adherence and Persistence to Lipid-Lowering Therapy in Type 1 Diabetes
AbstractIntroductionLipid-lowering therapy (LLT) reduces the risk of cardiovascular disease (CVD) in patients with type 1 diabetes (T1D). However, socioeconomic factors and gender may have an impact on the adherence to and non-persistence with LLT.MethodsThis was a nationwide register-based cohort study that included 6192 individuals with T1D aged ≥ 18 years who were registered in the Swedish National Diabetes Register and had initiated novel use of LLT. Information on socioeconomic parameters (source: Statistics Sweden) and comorbidity (source: National Patient Register) was collected. The individuals were followe...
Source: Diabetes Therapy - September 1, 2021 Category: Endocrinology Source Type: research

Correction to: One Year of Dapaglifozin Add-On Therapy Ameliorates Surrogate Indexes of Insulin Resistance and Adiposity in Patients with Type 2 Diabetes Mellitus
(Source: Diabetes Therapy)
Source: Diabetes Therapy - September 1, 2021 Category: Endocrinology Source Type: research

Cost Analysis of FreeStyle Libre ® 2 System in Type 2 Diabetes Mellitus Population
Conclusion FreeStyle Libre 2 system is a potential cost-saving strategy in patients with T2DM in Spain on a basal-bolus insulin regimen. (Source: Diabetes Therapy)
Source: Diabetes Therapy - August 24, 2021 Category: Endocrinology Source Type: research

Identification of the Inappropriate Clinical Actions (DON'T) to Improve the Management of Patients with Type 2 Diabetes Failing Basal Insulin Supported Oral Treatment: Results of Survey for a Panel of Diabetes Specialists in Italy
ConclusionA set of corrective experience-based actions to enact in a timely manner, which can assist physicians in improving clinical outcomes and patients ’ needs in terms of communications and interaction, is proposed. The list is intended to promote discussions among diabetes specialists to provide high-value diabetes care. (Source: Diabetes Therapy)
Source: Diabetes Therapy - August 20, 2021 Category: Endocrinology Source Type: research

Alcohol Consumption as a Causator and/or an Accelerator of Neuropathy in People With Diabetes Is Regularly Overlooked
AbstractPatients with diabetes and distal symmetrical polyneuropathy (DSP) are routinely evaluated for etiologies other than diabetes, including vitamin B12 deficiency, paraproteinemia, hypothyroidism and drug or autoimmune-induced neuropathy. However, the most common cause of DSP, next to that of diabetes, is alcohol intake, which is almost never evaluated. In addition to assessment of alcohol intake based on patient history, which often leads to an underestimation of alchohol intake, markers of a high alcohol intake (elevated liver enzymes, uric acid, triglycerides, low magnesium or low folic acid levels) should be obtai...
Source: Diabetes Therapy - August 19, 2021 Category: Endocrinology Source Type: research

Development of Exogenous Insulin Antibody Syndrome in a Patient with Newly Diagnosed Type  1 Diabetes Successfully Treated with Oral Immunosuppressive Monotherapy
AbstractExogenous insulin antibody syndrome (EIAS), which rarely occurs in the patient with type  1 diabetes, results in antibody-induced insulin resistance, hyperglycemia, ketosis, ketoacidosis, and hypoglycemia when insulin is released from the saturated insulin antibodies. Recommended treatment regimens include glucocorticoids, immunosuppressants, and plasmapheresis. In the patient with typ e 1 diabetes, glucocorticoids may by inducing and/or worsening ketoacidosis be contraindicated. With immunosuppressants, various anecdotal treatment regimens have been reported. Currently the most commonly recommended regim...
Source: Diabetes Therapy - August 17, 2021 Category: Endocrinology Source Type: research

Lower COVID-19 Mortality in Patients with Type 2 Diabetes Mellitus Taking Dipeptidyl Peptidase-4 Inhibitors: Results from a Turkish Nationwide Study
AbstractIntroductionTo investigate the effect of preexisting treatment with dipeptidyl peptidase-4 inhibitors (DPP-4is) on COVID-19-related hospitalization and mortality in patients with type 2 diabetes mellitus (T2DM).MethodsA multicenter, retrospective cohort study was conducted using patient data extracted from the Turkish National Electronic Database. All patients who tested positive for COVID-19 (PCR test) between 11 March through to 30 May 2020 were screened for eligibility (n = 149,671). Following exclusion of patients based on pre-determined inclusion criteria, patients with T2DM using a DPP-4i or glu...
Source: Diabetes Therapy - August 16, 2021 Category: Endocrinology Source Type: research

The Challenge of Sustainable Access to Telemonitoring Tools for People with Diabetes in Europe: Lessons from COVID-19 and Beyond
AbstractTelemedicine in diabetes care has been evolving over several years, particularly since the advent of cloud-connected technologies for diabetes management, such as glucose monitoring devices, including continuous glucose monitoring (CGM) systems, that facilitate sharing of glucose data between people with diabetes and their healthcare professionals in near-real time. Extreme social distancing and shielding in place for vulnerable patients during the COVID-19 pandemic has created both the challenge and the opportunity to provide care at a distance on a large scale. Available evidence suggests that glucose control has...
Source: Diabetes Therapy - August 14, 2021 Category: Endocrinology Source Type: research

Effects of Moderate-Intensity Aerobic Exercise on Blood Glucose Levels and Pregnancy Outcomes in Patients With Gestational Diabetes Mellitus: A Randomized Controlled Trial
AbstractIntroductionTo investigate the effects of structured moderate-intensity aerobic exercise on blood glucose, insulin, and pregnancy outcomes in patients with gestational diabetes mellitus (GDM).MethodsOne hundred one patients with GDM were randomly divided into a control group (50 cases) and an experimental group (51 cases) in a class 3 first-level general hospital. GDM patients in the control group received a personalized diabetes diet intervention, online education, and routine prenatal care. The experimental group added 6  weeks of moderate-intensity aerobic exercise in addition to the identical conditions gi...
Source: Diabetes Therapy - August 13, 2021 Category: Endocrinology Source Type: research

Does Current Diabetes Technology Improve Metabolic Control? A Cross-Sectional Study on the Use of Insulin Pumps and Continuous Glucose Monitoring Devices in a Nationwide Pediatric Population
AbstractObjectiveTo examine the use of multiple daily injections (MDI), insulin pumps, self-measured blood glucose (SMBG), and continuous glucose monitoring (CGM) systems, and their association with glycated hemoglobin (HbA1c), diabetic ketoacidosis (DKA), and severe hypoglycemia.MethodsIn a pediatric population-based nationwide cross-sectional study, we analyzed data from 2623 participants up to 18  years of age with type 1 diabetes, using 2017 annual data from the Norwegian Childhood Diabetes Registry. HbA1c was adjusted for age, gender, and diabetes duration. Using a linear mixed-effects model, we assessed HbA1c an...
Source: Diabetes Therapy - August 13, 2021 Category: Endocrinology Source Type: research

Effects of Moderate-Intensity Aerobic Exercise on Blood Glucose Levels and Pregnancy Outcomes in Patients With Gestational Diabetes Mellitus: A Randomized Controlled Trial
AbstractIntroductionTo investigate the effects of structured moderate-intensity aerobic exercise on blood glucose, insulin, and pregnancy outcomes in patients with gestational diabetes mellitus (GDM).MethodsOne hundred one patients with GDM were randomly divided into a control group (50 cases) and an experimental group (51 cases) in a class 3 first-level general hospital. GDM patients in the control group received a personalized diabetes diet intervention, online education, and routine prenatal care. The experimental group added 6  weeks of moderate-intensity aerobic exercise in addition to the identical conditions gi...
Source: Diabetes Therapy - August 13, 2021 Category: Endocrinology Source Type: research

Does Current Diabetes Technology Improve Metabolic Control? A Cross-Sectional Study on the Use of Insulin Pumps and Continuous Glucose Monitoring Devices in a Nationwide Pediatric Population
AbstractObjectiveTo examine the use of multiple daily injections (MDI), insulin pumps, self-measured blood glucose (SMBG), and continuous glucose monitoring (CGM) systems, and their association with glycated hemoglobin (HbA1c), diabetic ketoacidosis (DKA), and severe hypoglycemia.MethodsIn a pediatric population-based nationwide cross-sectional study, we analyzed data from 2623 participants up to 18  years of age with type 1 diabetes, using 2017 annual data from the Norwegian Childhood Diabetes Registry. HbA1c was adjusted for age, gender, and diabetes duration. Using a linear mixed-effects model, we assessed HbA1c an...
Source: Diabetes Therapy - August 13, 2021 Category: Endocrinology Source Type: research

The Durability of an Intensive, Structured Education-Based Rehabilitation Protocol for Best Insulin Injection Practice: The ISTERP-2 Study
AbstractIntroductionStudies on the durability of an intensive, structured education protocol on best insulin injection practice are missing for people with type 2 diabetes mellitus (T2DM).  The aim of this study was to assess the durability of an intensive, structured education-based rehabilitation protocol on best insulin injection practice in well-trained subjects from our previous intensive, multimedia intervention study registered as the ISTERP-1 study. A total of 158 subjects w ith T2DM from the well-trained group of the 6-month-long ISTERP-1 study, all of whom had successfully attained lower glucose levels ...
Source: Diabetes Therapy - August 12, 2021 Category: Endocrinology Source Type: research

Efficacy of a New Protocol of Premixed 70/30 Human Insulin in Haitian Youth with Diabetes
ConclusionThe use of sliding scales adjusted for missed SMBG tests and skipped meals, and frequent clinic visits that focus on patient self-management education significantly improved glycemic control in the patients with youth-onset diabetes in our study treated with premixed 70/30 human insulin in a low-resource setting. (Source: Diabetes Therapy)
Source: Diabetes Therapy - August 11, 2021 Category: Endocrinology Source Type: research

Assessment of Patient Satisfaction with On-Site Point-of-Care Hemoglobin A1c Testing: An Observational Study
This study had two phases: the retrospective phase (January 2017 to December 2017) and the prospective phase (January 2018 to December 2018). Patient satisfaction was assessed using the patient satisfaction questionnaire short form (PSQ-18) and on-site HbA1c point-of-care testing (HbA1c-POCT) satisfaction questionnaire.ResultsThis study included 75 patients with diabetes (37% type  1, 63% type 2) with a mean age of 44.35 (± 17.97) years. The adherence to physician recommendations for HbA1c testing frequency increased from 24% to 85% (before and after POCT implementation, respectively). High levels o...
Source: Diabetes Therapy - August 7, 2021 Category: Endocrinology Source Type: research

Effectiveness of IGlarLixi, a Fixed-Ratio Combination of Insulin Glargine 100 U/mL and Lixisenatide, in People with Type 2 Diabetes
This study aimed to assess the effectiveness of the insulin glargine + lixisenatide (iGlarLixi) FRC on glycaemic control and hypoglycaemia in real-life settings.MethodsThis non-interventional, 26-week study included participants aged 18 –80 years with suboptimally controlled type 2 diabetes (T2D) using oral antidiabetics (OADs) ± basal insulin therapy. The primary efficacy endpoint was the proportion of participants who achieved at least a 1% decrease in glycated haemoblobin (HbA1c) level from baseline to week 26.ResultsOf the 441 participants eligible for entry into the study, 353 were...
Source: Diabetes Therapy - August 6, 2021 Category: Endocrinology Source Type: research

The Influence of Tofogliflozin on Treatment-Related Quality of Life in Patients with Type  2 Diabetes Mellitus
AbstractIntroductionTreatment-related quality of life (QOL) is an important aspect of diabetes management. We evaluated the influence of a sodium-glucose cotransporter  2 (SGLT2) inhibitor, tofogliflozin, on treatment-related QOL in Japanese patients with type 2 diabetes mellitus (T2DM).MethodsThis is the prespecified subanalysis study of the “Using TOfogliflozin for Possible better Intervention against Atherosclerosis for type 2 diabetes patients (UTOPIA)” trial. Treatment-related QOL was evaluated at baseline, week 26, week 52, and week 104 after the initiation of the study using...
Source: Diabetes Therapy - August 6, 2021 Category: Endocrinology Source Type: research

Correction to: Individualizing Time-in-Range Goals in Management of Diabetes Mellitus and Role of Insulin: Clinical Insights From a Multinational Panel
(Source: Diabetes Therapy)
Source: Diabetes Therapy - August 6, 2021 Category: Endocrinology Source Type: research

Effectiveness of IGlarLixi, a Fixed-Ratio Combination of Insulin Glargine 100 U/mL and Lixisenatide, in People with Type 2 Diabetes
This study aimed to assess the effectiveness of the insulin glargine + lixisenatide (iGlarLixi) FRC on glycaemic control and hypoglycaemia in real-life settings.MethodsThis non-interventional, 26-week study included participants aged 18 –80 years with suboptimally controlled type 2 diabetes (T2D) using oral antidiabetics (OADs) ± basal insulin therapy. The primary efficacy endpoint was the proportion of participants who achieved at least a 1% decrease in glycated haemoblobin (HbA1c) level from baseline to week 26.ResultsOf the 441 participants eligible for entry into the study, 353 were...
Source: Diabetes Therapy - August 6, 2021 Category: Endocrinology Source Type: research

Correction to: Individualizing Time-in-Range Goals in Management of Diabetes Mellitus and Role of Insulin: Clinical Insights From a Multinational Panel
(Source: Diabetes Therapy)
Source: Diabetes Therapy - August 6, 2021 Category: Endocrinology Source Type: research