Real-Life Management and Effectiveness of Insulin Pump with or Without Continuous Glucose Monitoring in Adults with Type 1 Diabetes
AbstractIntroductionTo describe and compare the routine use of continuous subcutaneous insulin infusion (CSII) in type 1 diabetes (T1D) patients with and without continuous glucose monitoring (CGM) in routine clinical practice and its relationship with glycemic outcomes.MethodsRetrospective observational case –control study collecting routine use of CSII and CGM in T1D patients between January 2016 and December 2016. Patients with T1D using sensor augmented pump (SAP) were matched by sex and disease duration in a 1:3 ratio with those treated only with CSII. Patients used a Paradigm Veo or 640G Medtroni c-Minimed®...
Source: Diabetes Therapy - March 21, 2019 Category: Endocrinology Source Type: research

Downregulation of T-Cell Transcription Factors in Adult Latent Autoimmune Diabetes with High-Titer Glutamic Acid Decaroxylase Antibody
ConclusionLADA patients with high-titer GADA express lower levels of T-cell transcription factors, including the Treg transcription factor FOXP3, which may contribute to differences in the clinical profile compared to LADA patients with low-titer GADA.Trial RegistrationClinicalTrials.gov identifier, NCT01159847. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 20, 2019 Category: Endocrinology Source Type: research

Establishing Expert, Multi-Disciplinary, Peer-Reviewed Consensus to Lead a Paradigm Shift in Optimal Blood Glucose Management
ConclusionThe expert group reviewed the responses and made recommendations based on the clear professional consensus demonstrated. These included the need to use new technology and data integration and that wider factors, including patient choice rather than cost alone, should inform formulary inclusion of BGM equipment.FundingLifeScan U.K. Ltd. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 19, 2019 Category: Endocrinology Source Type: research

Study Protocol for the Effects of Artificial Intelligence (AI)-Supported Automated Nutritional Intervention on Glycemic Control in Patients with Type 2 Diabetes Mellitus
AbstractIntroductionNutritional intervention is effective in improving glycemic control in patients with type 2 diabetes but requires large inputs of manpower. Recent improvements in photo analysis technology facilitated by artificial intelligence (AI) and remote communication technologies have enabled automated evaluations of nutrient intakes. AI- and mobile-supported nutritional intervention is expected to be an alternative approach to conventional in-person nutritional intervention, but with less human resources, although supporting evidence is not yet complete. The aim of this study is to test the hypothesis that AI-su...
Source: Diabetes Therapy - March 15, 2019 Category: Endocrinology Source Type: research

Hypoglycemia Abrogates the Vascular Endothelial Protective Effect of Exenatide in Type 2 Diabetes Mellitus
AbstractGlucagon-like peptide-1 (GLP-1) receptor agonists improve postprandial glucose, lipid metabolism, and vascular endothelial function. However, little is known about the effect of hypoglycemia on vascular endothelial function in patients on GLP-1 receptor agonist therapy. The aim of the present study was to determine the effect of hypoglycemia on vascular endothelial function in patients with type 2 diabetes mellitus (T2DM) treated with exenatide. Seventeen patients with T2DM underwent a meal tolerance test to examine the changes in vascular endothelial function and in glucose metabolism, both without exenatide and a...
Source: Diabetes Therapy - March 15, 2019 Category: Endocrinology Source Type: research

Sodium-Glucose Cotransporter-2 Inhibitors (SGLT-2i) Reduce Hospitalization for Heart Failure Only and Have No Effect on Atherosclerotic Cardiovascular Events: A Meta-Analysis
This study aims to shed light on this debatable issue.MethodsAn electronic database search (Cochrane Library, PubMed and Embase) was performed using two groups of terms [ “sodium glucose cotransporter2 inhibitor”, “dapagliflozin”, “canagliflozin”, “empagliflozin”, “ertugliflozin”] AND [“major adverse cardiac events”, “MACE”, “cardiovascular death or hospitalization for heart failure”, non-fatal myocardial infarction”, “non-fatal st roke”, “cardiovascular death”, “hospitalization for heart fail...
Source: Diabetes Therapy - March 14, 2019 Category: Endocrinology Source Type: research

Lack of Treatment Persistence and Treatment Nonadherence as Barriers to Glycaemic Control in Patients with Type 2 Diabetes
AbstractTreatment persistence (continuing to take medication for the prescribed period) and treatment adherence (complying with the prescription in terms of drug schedules and dosage) are both important when treating chronic diseases such as type 2 diabetes (T2D). They can be indicators of patient satisfaction with treatment. In T2D, the achievement of optimal outcomes requires both persistence with and adherence to prescribed therapy. Poor persistence with and adherence to T2D medication can have profound consequences for the patient, including non-achievement of glycaemic goals and an increased risk of long-term complica...
Source: Diabetes Therapy - March 8, 2019 Category: Endocrinology Source Type: research

Patient Preferences for GLP-1 Receptor Agonist Treatment of Type 2 Diabetes Mellitus in Japan: A Discrete Choice Experiment
ConclusionIn this study, reduction in CV risk and HbA1c change were the key drivers of GLP-1 RA medication preference in Japanese patients with T2D. Overall, the majority of the patients preferred a product with attribute levels reflecting the semaglutide 0.50  mg profile, with a known CV risk reduction benefit and superior HbA1c reduction.FundingNovo Nordisk. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 7, 2019 Category: Endocrinology Source Type: research

Excessive Sodium Bicarbonate Infusion May Result in Osmotic Demyelination Syndrome During Treatment of Diabetic Ketoacidosis: A Case Report
ConclusionsWe recommend that in the case of DKA, the correction of hypokalemia should be prioritized during treatment. Sodium bicarbonate infusion should be reserved for pH  
Source: Diabetes Therapy - March 6, 2019 Category: Endocrinology Source Type: research

The Association Between Trimester-Specific Weight Gain and Severe Preeclampsia/Adverse Perinatal Outcome in Gestational Diabetes Mellitus Complicated by Preeclampsia: A Retrospective Case Study
ConclusionsThe trimester-specific weight gain has a significant impact on the perinatal outcomes among pregnant women with both GDM and preeclampsia. This study is helpful for carry out risk monitoring in time, identifying early warning signs, and improving maternal and infant health. (Source: Diabetes Therapy)
Source: Diabetes Therapy - March 5, 2019 Category: Endocrinology Source Type: research

A Retrospective Database Study of Liraglutide Persistence Associated with Glycemic and Body Weight Control in Patients with Type 2 Diabetes
This study compared glycated hemoglobin (HbA1c) and other outcomes in patients with type 2 diabetes who continued treatment with liraglutide for over 12  months with those who discontinued treatment earlier, in a real-life setting.MethodsThis is a retrospective study of adult patients with type 2 diabetes from Maccabi Healthcare Services in Israel, who initiated treatment with liraglutide from 2010 to 2015. Mean HbA1c and body weight change from initiation to after 24  months was compared between patients who received liraglutide for at least 12 months (“continuers”) and those who discontinued wi...
Source: Diabetes Therapy - February 27, 2019 Category: Endocrinology Source Type: research

EADSG Guidelines: Insulin Storage and Optimisation of Injection Technique in Diabetes Management
AbstractTo date, insulin therapy remains the cornerstone of diabetes management; but the art of injecting insulin is still poorly understood in many health facilities. To address this gap, the Forum for Injection Technique and Therapy Expert Recommendations  (FITTER) published recommendations on injection technique after a workshop held in Rome, Italy in 2015. These recommendations are generally applicable to the majority of patients on insulin therapy, athough they do not explore alternative details that may be suitable for low- and middle-income cou ntries. The East Africa Diabetes Study Group sought to address this...
Source: Diabetes Therapy - February 27, 2019 Category: Endocrinology Source Type: research

Higher Baseline Serum Irisin Decreases Risk for Body Mass Index Increment in Chinese Populations: A 3.2-Year Cohort Study
This study based on the data collected in the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION). The cross-sectional cohort study was carried out from May 2011 to August 2011, and a longitudinal cohort study was conducted from July 2014 to October 2014 to complete the first 3.2-year follow-up. We enrolled 93 low-weight subjects (BMI  
Source: Diabetes Therapy - February 27, 2019 Category: Endocrinology Source Type: research

Evaluating the User Performance and Experience with a Re-Engineered 4  mm × 32G Pen Needle: A Randomized Trial with Similar Length/Gauge Needles
In this study we evaluated patient-reported outcomes of an investigational newly re-engineered 4  mm × 32G PN, the BD Nano™ 2nd Gen (also known by its “PRO” brand extension in many markets outside of the USA). In place of a conventional cylindrical posted hub, the investigational PN’s hub is contoured with an expanded surface area. The investigational PN also includes a redesigned i nner shield that includes tactile ridges and a remodeled outer cover with improved proportions and attachment grips.MethodsThis was a multi-site, prospective, open-label, two-period crossover trial. Ind...
Source: Diabetes Therapy - February 27, 2019 Category: Endocrinology Source Type: research

Population Pharmacokinetics of Semaglutide for Type 2 Diabetes
AbstractIntroductionThe aim of the present analysis was to characterise the absorption, distribution and elimination of semaglutide by means of population pharmacokinetic (PK) models using data from nine clinical pharmacology trials conducted in both healthy subjects and those with type 2 diabetes.MethodsData were obtained from trials with subcutaneous and intravenous administration of semaglutide that utilised frequent PK sampling and included a total of 353 subjects with 10,573 concentration values.ResultsSemaglutide PK properties across trials, drug product strengths and populations were well characterised by a two-comp...
Source: Diabetes Therapy - February 20, 2019 Category: Endocrinology Source Type: research

Addition of Basal Insulin to Oral Antidiabetic Agents in Patients with Inadequately Controlled Type 2 Diabetes Leads to Improved HbA1c Levels: Metabolic Control, Frequency of Hypoglycemia, and Insulin Titration Analysis as Results of a Prospective Observational Study (BALI Study)
AbstractIntroductionDespite the continuously growing number of therapeutic options for patients with type 2 diabetes mellitus (T2DM), a large percentage of these individuals fail to achieve their glycated hemoglobin (HbA1c) target. The aim of this study was to determine the change in metabolic control in insulin-na ïve T2DM patients inadequately controlled with oral antidiabetic drugs (OADs) at 6 months after initiating basal insulin treatment as add-on to existing OADs.MethodsThis was a non-interventional prospective study conducted from June 2013 to December 2014 in 137 centers in the Czech Republic under routine cl...
Source: Diabetes Therapy - February 20, 2019 Category: Endocrinology Source Type: research

C-Peptide Area Under the Curve at Glucagon Stimulation Test Predicts Glucose Improvements by GLP-1 Receptor Analogue: A Retrospective Observational Study
This study aimed to identify predictors of the efficacy of GLP-1ra on Hemoglobin A1c (HbA1c) in patients with insulin-independent diabetes.MethodsIn total, 58 patients with insulin-independent diabetes were included. Patients were included if their β-cell function was evaluated via a glucagon stimulation test (GST) before the introduction of GLP-1ra therapy. β-Cell function-related indices, such as the C-peptide index (CPI), increments in C-peptide immunoreactivity (CPR) after glucagon stimulation (ΔCPR), and the area under the CPR curve ( CPR-AUC) during the GST, were evaluated. HbA1c and body weight (BW) ...
Source: Diabetes Therapy - February 20, 2019 Category: Endocrinology Source Type: research

Quality of Life is Markedly Impaired by Rheumatological and Skin Manifestations in Patients with Type 1 Diabetes: A Questionnaire Survey
AbstractIntroductionTo estimate lifetime prevalence of diabetes-related upper limb and non-acquired skin manifestations in a representative type 1 diabetes (T1D) population and to identify associations between these conditions and quality of life.MethodsA questionnaire on these complications and measures of quality of life (World Health Organization –Five Well-Being Index [WHO-5]), depression, and diabetes-specific burden (Problem Areas in Diabetes [PAID] scale) was sent to all T1D patients in a Danish clinic (N = 583).ResultsThe response rate was 68.6%. Lifetime prevalence of any upper limb soft tissue...
Source: Diabetes Therapy - February 19, 2019 Category: Endocrinology Source Type: research

Improvement in Quality of Care for Patients with Type 2 Diabetes in Hungary Between 2008 and 2016: Results from Two Population-Based Representative Surveys
ConclusionOur study demonstrated that if standardized indicators are investigated in population-based samples, the effectiveness of T2DM care can be monitored by ad hoc surveys. The systematic application of this approach completed with the detailed documentation of the applied therapies could demonstrate the public health impact of certain modifications in T2DM care. An overall improvement in metabolic control (glycaemic control, lipid status and obesity) was observed, which was not accompanied by improved therapeutic target achievement for systolic blood pressure. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 15, 2019 Category: Endocrinology Source Type: research

Rates of Hypoglycemia Predicted in Patients with Type 2 Diabetes on Insulin Glargine 300 U/ml Versus First- and Second-Generation Basal Insulin Analogs: The Real-World LIGHTNING Study
AbstractIntroductionThe LIGHTNING study applied conventional and advanced analytic approaches to model, predict, and compare hypoglycemia rates of people with type 2 diabetes (T2DM) on insulin glargine 300 U/ml (Gla-300) with those on first-generation (insulin glargine 100 U/ml [Gla-100]; insulin detemir [IDet]) or second-generation (insulin degludec [IDeg]) basal-insulin (BI) analogs, utilizing a large real-world database.MethodsData were collected between 1 January 2007 and 31 March 2017 from the Optum Humedica US electronic health records [EHR] database. Patient-treatments, the period during which a patient used a speci...
Source: Diabetes Therapy - February 14, 2019 Category: Endocrinology Source Type: research

Predictive Modeling of Hypoglycemia Risk with Basal Insulin Use in Type 2 Diabetes: Use of Machine Learning in the LIGHTNING Study
ConclusionIt is hoped that results of the LIGHTNING study will help facilitate real-world clinical decision-making in addition to providing a clinically relevant predictive model of hypoglycemia risk.FundingSanofi. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 14, 2019 Category: Endocrinology Source Type: research

The Standard of Care in Type 2 Diabetes: Re-evaluating the Treatment Paradigm
The objective of this symposium was to provide an overview of the efficacy and safety of glucose-lowering drugs, focussing in particular on sulfonylureas (SUs) in patients with T2D using data taken from both randomised controlled trials (RCTs) and real-world studies, the application of strategies to ensure optimal patient adherence and clinical outcomes, and the optimal use of SUs in terms of dose adjustment and agent choice to ensure the best clinical outcome. The symposium began by exploring a profile of the typical patient seen in diabetes clinical practice and the appropriate management of such a patient in the real wo...
Source: Diabetes Therapy - February 13, 2019 Category: Endocrinology Source Type: research

Association of the Serum Total Cholesterol to Triglyceride Ratio with Diabetic Retinopathy in Chinese Patients with Type 2 Diabetes: A Community-Based Study
ConclusionWe found a novel positive association between TC/TG ratio and presence of DR in Chinese individuals with T2DM. Although longitudinal data are needed, this finding contributes to the accumulating evidence that a high TC/TG ratio may be implicated in DR. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 13, 2019 Category: Endocrinology Source Type: research

Use of Continuous Glucose Monitoring in People with Type 1 Diabetes: Perspectives of Two People with Diabetes and Physician Perspective
This article details perspectives from two individuals with type 1 diabetes (T1DM) who use continuous glucose monitoring (CGM) devices to improve their quality of life and self-management of diabetes. It provides a unique perspective of how CGM can make living with T1DM safer and easier, while improving the time spent in the target glucose range (time in range). The perspectives of these two individuals highlight both the immediate need for improved access and support for CGM as well as the need for an understanding of the benefits of using non-medically approved technologies. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 8, 2019 Category: Endocrinology Source Type: research

Insights for Care: The Healthcare Utilisation and Cost Impact of Managing Type 2 Diabetes-Associated Microvascular Complications
ConclusionThis study of patients with T2DM in a typical secondary care provider in the UK showed that avoiding the progression of microvascular complications could provide substantial cost savings through targeted interventions that improve outcomes and lower resource use.FundingMerck Sharp& Dohme Limited. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 8, 2019 Category: Endocrinology Source Type: research

Diagnostic Accuracy of Glycated Haemoglobin and Average Glucose Values in Type 2 Diabetes Mellitus Treated with Premixed Insulin
ConclusionThe relationship between HbA1c and ABG estimations may be different in various patients; therefore, it seems that the use of one equation in all populations may not be reliable. Broad assessment of ABG as a tool that may replace HbA1c measurements should be recommended only with caution, providing the possible limitations and confidence intervals.FundingBioton S.A. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 8, 2019 Category: Endocrinology Source Type: research

Characteristics of Patients with Diabetes Initiating Sodium Glucose Co-transporter-2 Inhibitors (SGLT2i): Real-World Results from Three Administrative Databases in Japan
ConclusionPatients initiating SGLT2i therapy differed in several characteristics from new users of other OADs. SGLT2i were prescribed more frequently to younger patients, those at increased cardiovascular risk or those with poorer glycemic control.FundingAstellas Pharma Inc., Tokyo, Japan. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 7, 2019 Category: Endocrinology Source Type: research

Cost-Effectiveness of Continuous Subcutaneous Insulin Infusion Versus Multiple Daily Injections in Patients with Poorly Controlled Type 2 Diabetes in Finland
ConclusionIn Finland, CSII is likely to represent a cost-effective treatment alternative for patients with type 2 diabetes with poor glycemic control despite optimization of MDI. In such patients, CSII is associated with improved clinical outcomes relative to MDI, with the higher acquisition costs partly offset by a lower lifetime incidence and cost of diabetes-related complications.FundingMedtronic International S àrl. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 7, 2019 Category: Endocrinology Source Type: research

Incretin-Based Antihyperglycemic Agents for the Management of Acute Ischemic Stroke in Patients with Diabetes Mellitus: A Review
AbstractDiabetes mellitus (DM) is a major risk factor for ischemic stroke. Moreover, patients with DM suffer more severe strokes and have worse functional outcome following an acute stroke than patients without DM. In this context, data from animal studies and emerging evidence from clinical studies suggest that incretin-based antihyperglycemic agents might exert beneficial effects in patients with DM who suffer ischemic stroke. It appears that these agents exert neuroprotective actions that might both reduce infarct size and promote recovery. The present review summarizes the evidence on the potential role of incretin-bas...
Source: Diabetes Therapy - February 6, 2019 Category: Endocrinology Source Type: research

Efficacy of Autologous Bone Marrow Mononuclear Cell Transplantation Therapy for Type 2 Diabetes Mellitus: An Updated Meta-Analysis
ConclusionAutologous stem cell therapy showed a beneficial effect on T2DM. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 6, 2019 Category: Endocrinology Source Type: research

Effect of Remote Glucose Monitoring Utilizing Computerized Insulin Dose Adjustment Algorithms: A Pilot Project
ConclusionRemote glucose monitoring utilizing computerized insulin dose adjustment algorithms saved time for both providers and patients while effectively improving glycemia.FundingThe Leonard M. Lipman Charitable Trust and Mellitus Health. (Source: Diabetes Therapy)
Source: Diabetes Therapy - February 5, 2019 Category: Endocrinology Source Type: research

The Effect of Linagliptin versus Metformin Treatment-Related Quality of Life in Patients with Type 2 Diabetes Mellitus
ConclusionWe did not find significantly better treatment-related QOL with linagliptin among Japanese patients with T2DM. In terms of treatment convenience, our data showed that linagliptin was superior to metformin.FundingThis study was financially supported by Nippon Boehringer Ingelheim Co., Ltd. and Eli Lilly and Company. The journal ’s article processing fees were covered by a research fund from Juntendo University.Clinical Trial RegistrationUMIN000022953. (Source: Diabetes Therapy)
Source: Diabetes Therapy - January 25, 2019 Category: Endocrinology Source Type: research

Epidemiology, Quality of Life, and Costs Associated with Hypoglycemia in Patients with Diabetes in Spain: A Systematic Literature Review
ConclusionAlthough the data included in the SLR were difficult to synthesize due to heterogeneity of the study designs and patient characteristics in the 14 studies, our search identified a high burden associated with hypoglycemic events in terms of HRU and costs, and patients ’ QoL. Further research is recommended to reach a consensus on hypoglycemia definition and study design to provide robust evidence on the burden of hypoglycemia and to accurately weigh the impact of this acute complication in Spain.FundingEli Lilly and Company. (Source: Diabetes Therapy)
Source: Diabetes Therapy - January 19, 2019 Category: Endocrinology Source Type: research

Efficacy and Safety of Premixed Human Insulin Combined with Sulfonylureas in Type 2 Diabetic Patients Previously Poorly Controlled with Insulin
AbstractIntroductionSome type 2 diabetes (T2DM) patients treated with premixed insulin alone or in combination with oral glucose-lowering agents (without sulfonylureas) cannot reach the required glucose targets. Clinical studies have demonstrated that diabetes patients treated with sulfonylureas achieve stable glycemic control, with a low hypoglycemic rate. The aim of our study was to evaluate the efficacy and safety of therapy with the combination of premixed insulin and sulfonylureas.MethodsA total of 120 patients with T2DM who were unable to achieve glycemic control on premixed human insulin were randomized into four gr...
Source: Diabetes Therapy - January 18, 2019 Category: Endocrinology Source Type: research

Austrian Experience with Lixisenatide Under Real-Life Conditions: A Prospective Observational Study
ConclusionLixisenatide demonstrated a similar efficacy and safety profile under real-life conditions as previously shown in randomized clinical trials.Fundingsanofi-aventis GmbH Austria. (Source: Diabetes Therapy)
Source: Diabetes Therapy - January 17, 2019 Category: Endocrinology Source Type: research

Association Between Metformin and Sulfonylurea Monotherapies and Cancer Incidence: A Real-World Cohort Study in Shanghai, China
ConclusionThe real-world evidence suggested that the use of metformin or sulfonylurea was associated with lower risk of cancer incidence in a cohort of newly onset type 2 diabetes mellitus patients. (Source: Diabetes Therapy)
Source: Diabetes Therapy - January 8, 2019 Category: Endocrinology Source Type: research

Impact of Insulin Injection and Infusion Routines on Lipohypertrophy and Glycemic Control in Children and Adults with Diabetes
AbstractIntroductionProper insulin injection/infusion is essential to optimize insulin absorption and action. Guidelines on insulin injection techniques are available. Lipohypertrophy (LH) is a local complication of insulin therapy, which results in erratic absorption and impaired glycemic control.MethodsChildren and adults with type 1 diabetes on insulin injection or infusion were enrolled in the study. Subjects were interviewed and filled in a questionnaire on injection/infusion routines. Sites of injection/infusion were examined by trained diabetes educators, and capillary HbA1c was obtained.ResultsOne hundred sixty-nin...
Source: Diabetes Therapy - January 8, 2019 Category: Endocrinology Source Type: research

Clinical Trials on Diabetic Nephropathy: A Cross-Sectional Analysis
ConclusionDespite the financial and human resources involved and the relevance for therapeutic guidelines and clinical decisions, about one-third of phase III clinical trials on diabetic nephropathy remain unpublished. Interventions used in published trials showed a low efficacy on renal outcome.FundingDeutsche Forschungsgemeinschaft (DFG): SFB 1118. (Source: Diabetes Therapy)
Source: Diabetes Therapy - January 7, 2019 Category: Endocrinology Source Type: research

Effect of Dulaglutide Versus Liraglutide on Glucose Variability, Oxidative Stress, and Endothelial Function in Type 2 Diabetes: A Prospective Study
ConclusionWe showed that once-weekly dulaglutide was comparable to once-daily liraglutide in terms of oxidative stress and endothelial function. Switching from liraglutide to dulaglutide improved convenience by decreasing the number of injections without deteriorating glucose metabolism.Trial RegistrationThis trial was registered with the University Hospital Medical Information Network (UMIN no. 000034353) on 10 October 2018. (Source: Diabetes Therapy)
Source: Diabetes Therapy - January 5, 2019 Category: Endocrinology Source Type: research

Efficacy Comparison of Preprandial and Postprandial Prandilin 25 Administration in Patients with Newly Diagnosed Type 2 Diabetes Using a Continuous Glucose Monitoring System
ConclusionIn patients with T2DM managed with premixed insulin lispro 25, postprandial injection (within 30  min of meal onset) may be an acceptable alternative to preprandial injection when the regular preprandial insulin dose is omitted.Trial RegistrationChinese Clinical Trial Register identifier: ChiCTR1800015828. (Source: Diabetes Therapy)
Source: Diabetes Therapy - January 4, 2019 Category: Endocrinology Source Type: research

Lilly Insulin Glargine Versus Lantus ® in Insulin-Naïve and Insulin-Treated Adults with Type 2 Diabetes: A Randomized, Controlled Trial (ELEMENT 5)
This study compared the efficacy and safety of similar U-100 insulin glargine products, namely, Lilly insulin glargine (LY IGlar; Basaglar®) and the reference insulin glargine product (IGlar; Lantus®), used once daily in combination with oral antihyperglycemic medications (OAMs) in adults with type 2 diabetes (T2D).MethodsELEMENT 5 was a phase III, randomized, multinational, open-label, treat-to-target, 24-week trial. Participants were insulin na ïve (glycated hemoglobin [HbA1c] ≥ 7.0% to ≤ 11.0%) or on basal insulin (IGlar, neutral protamine Hagedorn or insulin detemir; HbA1c...
Source: Diabetes Therapy - January 2, 2019 Category: Endocrinology Source Type: research

A Summary of 2018 and What Lies Ahead for Diabetes Therapy in 2019
(Source: Diabetes Therapy)
Source: Diabetes Therapy - January 2, 2019 Category: Endocrinology Source Type: research

Study Protocol for the Effects of Formula Diet with Dapagliflozin on Metabolic Improvement and Body Composition in Type 2 Diabetes Mellitus
This study is ongoing and scheduled to complete in June 2019. The findings of this study will be disseminated through peer-reviewed publications and conference presentations.Trial RegistrationUniversity Hospital Medical Information Network (UMIN) 000024580.FundingThis study was carried out under contract with the specified nonprofit corporation Hokkaido Institute of Health Sciences, based on a grant from AstraZeneca Co., Ltd. and Ono Pharmaceutical Co., Ltd. for an investigator-initiated clinical trial. The authors funded the journals article processing charges. (Source: Diabetes Therapy)
Source: Diabetes Therapy - December 21, 2018 Category: Endocrinology Source Type: research

Behavioral Strategies to Lower Postprandial Glucose in Those with Type 2 Diabetes May Also Lower Risk of Coronary Heart Disease
ConclusionThese secondary analyses suggest that broad-spectrum lifestyle interventions that focus on lowering PPG may lower the risk of future CHD, which could guide future research.Trial RegistrationClinicalTrials.gov ID: NCT02432391. (Source: Diabetes Therapy)
Source: Diabetes Therapy - December 18, 2018 Category: Endocrinology Source Type: research

Pregabalin in the Management of Painful Diabetic Neuropathy: A Narrative Review
AbstractPregabalin is a first-line treatment in all major international guidelines on the management of painful diabetic neuropathy (pDPN). Treatment with pregabalin leads to a clinically meaningful improvement in pain scores, offers consistent relief of pain and has an acceptable tolerance level. Despite its efficacy in relieving neuropathic pain, more robust methods and comprehensive studies are required to evaluate its effects in relation to co-morbid anxiety and sleep interference in pDPN. The sustained benefits of modulating pain have prompted further exploration of other potential target sites and the development of ...
Source: Diabetes Therapy - December 18, 2018 Category: Endocrinology Source Type: research

Investigating the Association Between Baseline Characteristics (HbA1c and Body Mass Index) and Clinical Outcomes of Fast-Acting Insulin Aspart in People with Diabetes: A Post Hoc Analysis
AbstractIntroductionThe aim of this study was to investigate the association between baseline characteristics [HbA1c and body mass index (BMI)] and the effect of mealtime fast-acting insulin aspart (faster aspart) relative to insulin aspart (IAsp) or basal-only insulin therapy on several efficacy and safety outcomes in people with diabetes.MethodsPost hoc analysis of three randomised phase 3a trials in people with type 1 diabetes (T1D; onset 1) and type 2 diabetes (T2D; onset 2 and 3). Participants (N = 1686) were stratified according to baseline BMI (
Source: Diabetes Therapy - December 13, 2018 Category: Endocrinology Source Type: research

High Dose Prednisolone Lowers Plasma Glycated Albumin Levels Compared to Actual Glycemic Control: A Retrospective Observational Study
In this study, we determined whether prednisolone (PSL) administration lowers plasma GA.MethodsWe investigated the factors affecting GA using multivariate analysis in 48 subjects with connective tissue diseases (CTDs).ResultsMultiple regression analysis of GA showed that the dose of PSL [β = − 1.36; 95% confidence interval (CI) − 2.59 to − 0.14;p = 0.03], age (β = 0.06; 95% CI 0.03–0.09;p 
Source: Diabetes Therapy - December 13, 2018 Category: Endocrinology Source Type: research

Impact of Duodeno-Jejunal Bypass Liner (EndoBarrierTM) Implantation on Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus (T2DM): A Study Protocol for a Pilot Trial
This study will give mechanistic insights in particulr into changes of insulin sensitivity, beta-cell function or microbiome changes over time in subjects implanted with an EndobarrierTM device.Trial registrationNCT02769728, Registered 12 May 2016. Current Protocol Date/Version: 04 September 2017/Version 1.9. (Source: Diabetes Therapy)
Source: Diabetes Therapy - December 11, 2018 Category: Endocrinology Source Type: research

A Review of the Safety and Adverse Event Profile of the Fixed-Ratio Combination of Insulin Glargine and Lixisenatide
ConclusioniGlarLixi has a safety profile that is consistent with that of its two active components insulin glargine and lixisenatide, with no signals for pancreatitis or thyroid C  cell tumors, and no black-box warning for iGlarLixi. There were no unexpected safety findings; iGlarLixi had beneficial effects on glycemic control, with no increased risk of hypoglycemia, despite a greater glycated hemoglobin A1c reduction. In addition, there were also fewer gastrointestinal AEs associated with iGlarLixi compared with lixisenatide alone.FundingSanofi US Inc. (Source: Diabetes Therapy)
Source: Diabetes Therapy - December 11, 2018 Category: Endocrinology Source Type: research

Once-Weekly Semaglutide Versus Once-Daily Liraglutide for the Treatment of Type 2 Diabetes: A Long-Term Cost-Effectiveness Analysis in Estonia
ConclusionOnce-weekly semaglutide was considered highly cost-effective versus liraglutide 1.2  mg for the treatment of patients with type 2 diabetes in Estonia.FundingNovo Nordisk A/S.Plain Language SummaryPlain language summary available for this article. (Source: Diabetes Therapy)
Source: Diabetes Therapy - December 7, 2018 Category: Endocrinology Source Type: research